Section of Support of Animal Experimentation
Toshio Imai, D.V.M., Ph.D.
The establishment and characterization of patient-derived xenograft (PDX) model of variety types of cancers in our team will accumulate knowledge and experience of case-by-case methodologies for PDX establishment and construct a systematic library of PDX with omics-based data sets.
It is important to make consideration for the biological safety in handling not only surgical specimens themselves but also PDX and related-biological resources. We contribute to consolidate the facility and rules to ensure such biological safety of experiment environment and to conduct training for researchers and technical experts on animal experiment.
- Imai, T., Cho, Y.M., Takahashi, M., Kitahashi, T., Takami, S., Nishikawa, A., Ogawa, K.: High susceptibility of heterozygous (+/fa) lean Zucker rats to 7,12-dimethylbenz(a)anthracene –induced mammary carcinogenesis. Oncol. Rep. 29, 1914-1922 (2013) PMID:23467805
- Onuma, K., Ochiai, M., Takahashi, M., Imai, T., Nakagama, H., Hippo, Y.: Genetic reconstitution of tumorigenesis in primary intestinal cells. Proc. Natl. Acad. Sci., U.S.A., 110, 11127-11132 (2013) PMID:23776211
- Imai, T., Kitahashi, T.: A 13-week toxicity study of acrylamide administered in drinking water to hamsters. J. Appl. Toxicol. 34, 57-65 (2014) PMID:23129233
- Kitahashi, T., Takahashi, M., Imai, T.: Biphasic alterations in expression and subcellular localization of MUC1 in pancreatic ductal carcinogenesis in Syrian hamsters. Pancreas 44, 76-86 (2015) PMID:25036908