Pharmacy Division


Introduction
With the advent of the legal revision of medical fees in April 1996, the authorities concerned raised pharmaceutical care changes for patients. In addition, according to the revision of the Drugs, Cosmetics and Medical Instruments Act, in April, 1997, pharmacists are compelled to provide comprehensive drug information to patients. These changes clearly show the increasing appreciation of the role of pharmacists in educating patients to maintain proper drug usage. In fact, this is very important particularly in administering anti-cancer medications.
The primary aims of proper drug usage focus on (1) ensuring both efficacy and safety, and (2) cost-effectiveness. In the near future, pharmaco-economics will be required at all medical institutes as well as the more wide-scale collection of drug information from all over the world.

Routine Activities
"Pharmaceutical care" for patients has become the fundamental work of pharmacists at the National Cancer Center Hospital East. At the thoracic disease ward, pharmacists visit the bedside to deliver the prescription slip which explains the medicine, providing the name, dosage, site of action, time of administration and so on, so that the patient can understand the medicine which he or she takes. At the palliative care unit (PCU), how and how much medicine to take is precisely explained particularly for those scheduled for discharge, because it is important for these patients to fully understand the medication regimen to be used at home in order to maintain their physical and mental well-being. After discharge from the hospital, these patients are followed-up with pharmaceutical care at the outpatient clinic. As a matter of course, we also provide such care for other outpatients, if requested.
Since October, 1997, we have used a printing medication packet machine on a full scale basis, such that nurses and patients can verify drug names and indications. Aseptic preparation of IVH for both in- and outpatients and that of anti-cancer agents for outpatients receiving chemotherapy at the day care center are other important activities comprising our daily clinical duties. The former strongly supports cancer treatment or care at home for outpatients. New drugs under investigation are strictly controlled according to GCP manuals with computer registration of prescriptions.

New Developments
1. Medication instructions: Because we continuously strive to make medication instructions for patients more widespread, in 1997 we began providing written instructions, which are easy to understand, explaining the drug. This actually contributes to the patientÕs QOL (quality of life).
2. Drug information service: We promote our drug information service for medical staff members, using an intra-net installed in both drug and drug discrimination searching systems. In addition, we provide drug information with electronic files.
3. Computer-network-system for new-GCP: For investigational drug management, we provided an exclusive computer-network-system to carry out more precise management based on new-GCP.

Statistics
Number of prescriptions

19961997
Prepared in hospital pharmacy
Inpatients51,80755,653
Outpatients35,81539,746
Total87,62295,399
Prepared outside hospital1629

(0.04%*)(0.07%*)
*Persentage of outpatient prescriptions prepared outside hospital.

Aseptic Preparation of Injection Mixture

19961997
IVH Preparations11,3729,392
Anti-Cancer Drugs2,8745,135
Others1,0811,343

Investigational Drug Usage

19961997
Newly registered148
Ongoing study3626
Prescriptions2,1091,528


Number of House Preparations

19961997
Sterilized2129
Non-sterilized167162

Costs of Drugs Used

19961997
Total1,771,9102 (100.00)1,810,517 (100.00)
Internal/external medicines320,682 (18.10)371,717 (20.53)
Injections739,008 (47.71)793,986 (43.85)
Blood89,675 (5.06)90,437 (5.00)
X-ray194,328 (10.96)133,344 (7.37)
RI35,787 (2.02)204,266 (11.28)
Others220,070 (12.42)183,220 (10.12)
The figures in parentheses indicate %. (Unit : 1000 yen)

Injections

19961997
Total128,123134,251
Inpatients117,912124,862
Outpatients10,2119,389

(T. Domon)


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