Project Index Arranged by Category

Chemical and radiation carcinogenesis

Carcinogenicity of PhIP in mice 6

Genetic susceptibility of rats to colon carcinogenesis 6

Genetic alteration at minisatellite DNA sequences 7

The role of poly(ADP-ribose)polymerase in response to DNA damage and

carcinogenesis 7

The possibility of a mono(ADP-ribosyl)ation reaction by Helicobacter pylori 7

Susceptibility to chemical carcinogens of human c-Ha-ras gene transgenic rats 8

Isolation of a gene involved in the repair of an oxidative DNA damage, 8-hydroxyguanine 11

Mutagens in water from the Nishitakase River 24

Comutagenic action of norharman 24

Increased expression of inducible nitric oxide synthase (iNOS) in colon carcinomas 25

Heterocyclic amine (HCA) carcinogenesis 30

Rat genome study 30

Serine/threonine protein phosphatases (PPs) in carcinogenesis 31

Chemoprevention

Chemopreventive effects of lactoferrin and related compounds on rat colon tumor

development 8

Suppression of intestinal polyp development by a selective inhibitor of

cyclooxygenase-2 (COX-2), nimesulide 24

Viral carcinogenesis

Analysis of the cell tropism of HCV by using in vitro HCV-infected human

lymphocytes and hepatocytes 22

Quantitative analysis of HCV in extrahepatic organs 22

Analysis of cellular proteins interacting with the 3'-terminal structure of the HCV

genome 23

Functional analysis of HCV proteins 23

Growth regulation of T-cells expressing HTLV-I tax 23

Oncogenes and suppressor genes

Functional analysis of cancer-related genes 10

Familial cancer syndromes: genetic tests and clinical approaches 17

Genome analysis and positional cloning of leukemia-associated genes 18

Familial breast cancer 31

Genetic and epigenetic alterations

Aberrant DNA methylation and carcinogenesis 4

Genetic alterations in human cancers 10

Genomic instability and carcinogenesis 11

Mutation induction by extreme dryness 19

Analysis of gene amplification in cancer 26

Detection of aberrations of known genes in human cancers 28

Detection of aberrations in anonymous regions of the genome 28

Development of technologies for detection of DNA aberrations 29

Analysis of aberrant methylation in carcinogenesis 31

Analysis of precancerous lesions 40

Analysis of lung cancer patients with extreme clinicopathological features 40

Immunology

A novel monoclonal antibody permitting recognition of NKT cells in various

mouse strains 33

Tumor biology, invasion and metastasis

Molecular and cellular mechanisms of cancer metastasis and recurrence 5

Tumor-regressing factor: a novel factor related to but different from complement

component C3 9

Identification of genes involved in metastasis 11

Transcriptional regulation of UAG suppressor tRNA genes 15

Three-dimensional (3D) structures and vibrational spectra of biological molecules 15

Development and elongation of neurite-like outgrowth on SCLC cell lines 19

Cytotoxic factor present in the cabbage butterfly 25

Bone morphogenetic protein receptor in prostate cancer 27

Mechanisms of fibrotic focus formation in invasive ductal carcinoma of

the breast 36

Study of clinicopathological features associated with sites of recurrence in

breast carcinoma 37

Implication of nitric oxide in carcinogenesis and clinical course of cancer 41

Diagnosis and prognostic factors

Analysis of genetic and chromosomal alterations for human cancer diagnosis 4

Clinicopathological studies 5

Ectopic hormone/cytokine syndromes 16

The elevated thioredoxin serum levels in patients with hepatocellular carcinoma

and chronic gastritis 33

Development of a computer-assisted image diagnosis system 36

Clinicopathological studies of various cancers 37

Cancer Treatment

Inhibitory effects of oleic and docosahexaenoic acids on lung metastatic colony

formation and matrix metalloproteinase (MMP) activity 9

Synthesis of novel nucleosides 9

Biological and biochemical pharmacology 12

Drug resistance 12

Development of innovative therapy 13

Signaling pathway of apoptosis 14

Molecular therapeutics in cancer 16

Development of gene therapy for cancer 27

Targeting of the K-ras mutation in pancreatic cancer 32

Suicide gene therapy for peritoneal dissemination of pancreatic cancer 32

Medical care for the elderly in Japan 33

Diagnosing depression in cancer patients 42

Symptom management 43

Psychosocial and behavioral factors in the development of cancer 43

Epidemiology

Collection and analysis of cancer databases 20

Epidemiological studies 20

WHO Collaborating Centre for Reference on Smoking and Health 21

Etiological roles of foods and nutrients in cancer 38

Environmental and genetic interaction in the etiology of human cancer 39

An epidemiological evaluation of cancer prevention methods 39

Epidemiological and biostatistical support for basic and clinical research 39

Psychiatric epidemiology in cancer patients 42

Cancer information and biometry

JCOG Data Center 21

Research and development of clinical support systems 21

Development of a prototype for exhibiting pathology images of educational value

on the Internet 37