Section for Studies on Host-immune Response

16. Section for Studies on Host-Immune Response

　Research in the Section for Studies on Host-Immune Response has been focused on fundamental studies and clinical application of immunological mechanisms for the therapeutic treatment of malignant diseases.
The Identification of the Precursor of Mouse NK1.1⁺ Cytotoxic T Cells

　When hepatic and splenic mononuclear cells were cultured in the presence of IL-2, a new type of NK1.1⁺ T cell was formed. After IL-2-stimulation, some purified NK1.1- IL-2Rb⁺ T cells expressed NK1.1 and approximately 60% of the purified NK1.1⁺ T cells lost NK1.1 expression. Furthermore, IL-2-stimulated NK1.1⁺ T cells exerted an NK cell-like cytotoxic activity similar to that of the original NK1.1⁺ T cells indicating that NK1.1- IL-2Rb⁺ cells could express NK1.1 and exert NK cell-like cytotoxic activity regardless of their origin.⁽²⁰¹⁾
The Expression of Thioredoxin in Patients with Gastric Cancer

　Thioredoxin (TRX) is a redox-active protein with multiple intra- and extracellular functions. It exists ubiquitously in primitive cells such as E. coli and yeast up to higher mammals. Recently, augmentation of the expression and transcriptional level of TRX has been reported in tumors of various organs. The serum concentration of TRX in gastritis patients with H. pylori infection was much higher than that of the normal volunteers.⁽²⁰²⁾ The expression of TRX in gastric cancer was examined with respect to its histological type and depth of invasion. TRX is predominantly expressed in undifferentiated gastric cancer rather than in the differentiated type (p=0.001). this tendency was demonstrated by histochemistry of surgical specimens as well as by cytochemistry and Northern blot analysis of gastric cancer cell lines. Neither the depth of tumor invasion nor cell proliferation significantly determined the staining intensity for TRX.




	16. Section for Studies on Host-Immune Response



		Research in the Section for Studies on Host-Immune Response has been focused on fundamental studies and clinical application of immunological mechanisms for the therapeutic treatment of malignant diseases. The Identification of the Precursor of Mouse NK1.1⁺ Cytotoxic T Cells 　When hepatic and splenic mononuclear cells were cultured in the presence of IL-2, a new type of NK1.1⁺ T cell was formed. After IL-2-stimulation, some purified NK1.1- IL-2Rb⁺ T cells expressed NK1.1 and approximately 60% of the purified NK1.1⁺ T cells lost NK1.1 expression. Furthermore, IL-2-stimulated NK1.1⁺ T cells exerted an NK cell-like cytotoxic activity similar to that of the original NK1.1⁺ T cells indicating that NK1.1- IL-2Rb⁺ cells could express NK1.1 and exert NK cell-like cytotoxic activity regardless of their origin.⁽²⁰¹⁾ The Expression of Thioredoxin in Patients with Gastric Cancer 　Thioredoxin (TRX) is a redox-active protein with multiple intra- and extracellular functions. It exists ubiquitously in primitive cells such as E. coli and yeast up to higher mammals. Recently, augmentation of the expression and transcriptional level of TRX has been reported in tumors of various organs. The serum concentration of TRX in gastritis patients with H. pylori infection was much higher than that of the normal volunteers.⁽²⁰²⁾ The expression of TRX in gastric cancer was examined with respect to its histological type and depth of invasion. TRX is predominantly expressed in undifferentiated gastric cancer rather than in the differentiated type (p=0.001). this tendency was demonstrated by histochemistry of surgical specimens as well as by cytochemistry and Northern blot analysis of gastric cancer cell lines. Neither the depth of tumor invasion nor cell proliferation significantly determined the staining intensity for TRX.

16. Section for Studies on Host-Immune Response

The Identification of the Precursor of Mouse NK1.1+ Cytotoxic T Cells

The Expression of Thioredoxin in Patients with Gastric Cancer

The Identification of the Precursor of Mouse NK1.1⁺ Cytotoxic T Cells