List of Papers Published in 1998
1. Pathology Division1. Takayama T, Makuuchi M, Hirohashi S, Sakamoto M, Yamamoto J, Shimada K, Kosuge T, Okada S, Takayasu K, Yamasaki S. Early hepatocellular carcinoma as an entity with a high rate of surgical cure. Hepatology, 28:1241-1246, 1998 2. Sakamoto M, Hirohashi S. Natural history and prognosis of adenomatous hyperplasia and early hepatocellular carcinoma: multi-institutional analysis of 53 nodules followed up for more than 6 months and 141 patients with single early hepatocellular carcinoma treated by surgical resection or percutaneous ethanol injection. Jpn J Clin Oncol, 28:604-608, 1998 3. Sugitani S, Sakamoto M, Ichida T, Genda T, Asakura H, Hirohashi S. Hyperplastic foci reflect the risk of multicentric development of human hepatocellular carcinoma. J Hepatol, 28:1045-1053, 1998 4. Kanai Y, Ushijima S, Ochiai A, Eguchi K, Hui A-M, Hirohashi S. DNA hypermethylation at the D17S5 locus is associated with gastric carcinogenesis. Cancer Lett, 122:135-141, 1998 5. Kishimoto T, Kokura K, Ohkawa N, Makino Y, Yoshida M, Hirohashi S, Niwa S, Muramatsu M, Tamura T. Enhanced expression of a new class of liver-enriched b-Zip transcription factors, hepatocarcinogenesis-related transcription factor, in hepatocellular carcinomas of rats and humans. Cell Growth Differ, 9:337-344, 1998 6. Yoshioka H, Takeuchi T, Matsuno Y, Yamada T, Shimosato Y, Hirohashi S, Noguchi M. Analysis of loss of heterozygosity in small adenocarcinomas of the lung. Jpn J Clin Oncol, 28:240-244, 1998 7. Inoue M, Osaki T, Noguchi M, Hirohashi S, Yasumoto K, Kasai H. Lung cancer patients have increased 8-hydroxydeoxyguanosine levels in peripheral lung tissue DNA. Jpn J Cancer Res, 89:691-695, 1998 8. Hui A-M, Sun L, Kanai Y, Sakamoto M, Hirohashi S. Reduced p27Kip1 expression in hepatocellular carcinomas. Cancer Lett, 132:67-73, 1998 9. Hirohashi S. Inactivation of the E-cadherin-mediated cell adhesion system in human cancers. Am J Pathol, 153:333-339, 1998 10. Shimoyama Y, Shibata T, Kitajima M, Hirohashi S. Molecular cloning and characterization of a novel human classic cadherin homologous with mouse muscle cadherin. J Biol Chem, 273:10011-10018, 1998 11. Akimoto S, Ochiai A, Inomata M, Hirohashi S. Expression of cadherin-catenin cell adhesion molecules, phosphorylated tyrosine residues and growth factor receptor-tyrosine kinases in gastric cancers. Jpn J Cancer Res, 89:829-836, 1998 12. Fukuchi T, Sakamoto M, Tsuda H, Maruyama K, Nozawa S, Hirohashi S. b-catenin mutation in carcinoma of the uterine endometrium. Cancer Res, 58:3526-3528, 1998 13. Inomata M, Ochiai A, Sugihara K, Moriya Y, Yamaguchi N, Adachi Y, Kitano S, Hirohashi S. Macroscopic features at the deepest site of tumor penetration predicting liver metastases of colorectal cancer. Jpn J Clin Oncol, 28:123-128, 1998 14. Takagi Y, Ui-Tei K, Miyake T, Hirohashi S. Laminin-dependent integrin clustering with tyrosine-phosphorylated molecules in a Drosophila neuronal cell line. Neurosci Lett, 244:149-152, 1998 15. Honda K, Yamada T, Endo R, Ino Y, Gotoh M, Tsuda H, Yamada Y, Chiba H, Hirohashi S. Actinin-4, a novel actin-bundling protein associated with cell motility and cancer invasion. J Cell Biol, 140:1383-1393, 1998 16. Suzuki-Takaoka A, Yamada T, Gotoh M, Kanai Y, Imai K, Hirohashi S. Cloning and characterization of the human b4-integrin gene promoter and enhancers. J Biol Chem, 273:33848-33855, 1998 17. Tsuda H, Takarabe T, Shimamura K, Hirohashi S. Detection of alterations in chromosomes 16 and 1 by fluorescence in situ hybridization in breast tumors cytologically or histologically equivocal for malignancy. Pathobiology, 66:268-273, 1998 18. Tsuda H, Sakamaki C, Tsugane S, Fukutomi T, Hirohashi S. Prognostic significance of accumulation of gene and chromosome alterations and histological grade in node-negative breast carcinoma. Jpn J Clin Oncol, 28:5-11, 1998 19. Tsuda H, Akiyama F, Kurosumi M, Sakamoto G, Watanabe T. Establishment of histological criteria for high-risk node-negative breast carcinoma for a multi-institutional randomized clinical trial of adjuvant therapy. Jpn J Clin Oncol, 28:486-491, 1998 20. Tsuda H, Sakamaki C, Tsugane S, Fukutomi T, Hirohashi S. A prospective study of the significance of gene and chromosome alterations as prognostic indicators of breast cancer patients with lymph node metastases. Breast Cancer Res Treat, 48:21-32, 1998 21. Tsuda H, Hirohashi S. Multiple developmental pathways of highly aggressive breast cancers disclosed by comparison of histological grades and c-erbB-2 expression patterns in both the non-invasive and invasive portions. Pathol Int, 48:518-525, 1998 22. Narimatsu H, Iwasaki H, Nakayama F, Ikehara Y, Kudo T, Nishihara S, Sugano K, Okura H, Fujita S, Hirohashi S. Lewis and secretor gene dosages affect CA19-9 and DU-PAN-2 serum levels in normal individuals and colorectal cancer patients. Cancer Res, 58:512-518, 1998 23. Kumamoto K, Mitsuoka C, Izawa M, Kimura N, Otsubo N, Ishida H, Kiso M, Yamada T, Hirohashi S, Kannagi R. Specific detection of sialyl Lewis X determinant carried on the mucin GlcNAcb16GalNAca core structure as a tumor-associated antigen. Biochem Biophys Res Commun, 247:514-517, 1998 24. Hasegawa T, Matsuno Y, Niki T, Hirohashi S, Shimoda T, Takayama J, Watanabe C, Kaneko A, Sano T, Sato M, Suzuki J. Second primary rhabdomyosarcomas in patients with bilateral retinoblastoma. Am J Surg Pathol, 22:1351-1360, 1998 25. Matsuno Y, Morozumi N, Hirohashi S, Shimosato Y, Rosai J. Papillary carcinoma of the thymus. Am J Surg Pathol, 22:873-880, 1998 26. Nakanishi Y, Ochiai A, Yoshimura K, Kato H, Shimoda T, Yamaguchi H, Tachimori Y, Watanabe H, Hirohashi S. The clinicopathologic significance of small areas unstained by Lugols iodine in the mucosa surrounding resected esophageal carcinoma. Cancer, 82:1454-1459, 1998 27. Hasegawa T, Shimoda T, Hirohashi S, Hizawa K, Sano T. Collagenous fibroma (desmoplastic fibroblastoma). Arch Pathol Lab Med, 122:455-460, 1998 28. Hasegawa T, Matsuno Y, Shimoda T, Hirohashi S, Hirose T, Sano T. Frequent expression of bcl-2 protein in solitary fibrous tumors. Jpn J Clin Oncol, 28:86-91, 1998 29. Saito A, Hasegawa T, Shimoda T, Toda G, Hirohashi S, Tajima G, Moriya Y. Dedifferentiated chordoma: a case report. Jpn J Clin Oncol, 28:766-771, 1998 30. Anami Y, Matsuno Y, Yamada T, Takeuchi T, Nakayama H, Hirohashi S, Noguchi M. A case of double primary adenocarcinoma of the lung with multiple atypical adenomatous hyperplasia. Pathol Int, 48:634-640, 1998 31. Nakanishi Y, Matsuno Y, Shimoda T, Wada T, Yamazaki N, Yamamoto A, Hirohashi S. Eccrine porocarcinoma with melanocyte colonization. Br J Dermatol, 138:519-521, 1998 32. Nakasuka H, Okada S, Okusaka T, Ishii H, Ikeda M, Ito R, Kosakamoto H, Yoshimori M, Nakanishi Y, Sakamoto M. Undifferentiated carcinoma of the liver with neuroendocrine features: a case report. Jpn J Clin Oncol, 28:401-404, 1998 33. Okusaka T, Okada S, Ishii H, Ikeda M, Nakasuka H, Nagahama H, Iwata R, Furukawa H, Takayasu K, Nakanishi Y, Sakamoto M, Hirohashi S, Yoshimori M. Transarterial chemotherapy with zinostatin stimalamer for hepatocellular carcinoma. Oncology, 55:276-283, 1998 34. Seki K, Hasegawa T, Konegawa R, Hizawa K, Sano T. Primary liposarcoma of the stomach: a case report and a review of the literature. Jpn J Clin Oncol, 28:284-288, 1998 35. Kubota K, Akasu T, Nakanishi Y, Sugihara K, Fujita S, Moriya Y. Perianal Pagets disease associated with rectal carcinoma: a case report. Jpn J Clin Oncol, 28:347-350, 1998 36. Matsuo K, Fukutomi T, Tsuda H, Kanai Y, Akashi-Tanaka S, Nanasawa T. Apocrine carcinoma of the breast: clinicopathological analysis and histological subclassification of 12 cases. Breast Cancer, 5:279-284, 1998 37. Okumura T, Fukutomi T, Tsuda H, Kanai Y, Ushijima T, Akashi-Tanaka S, Nanasawa T. Japanese late-onset breast cancer families: their clinicopathological characteristics and absence of BRCA1 and BRCA2 germline mutations. Breast Cancer, 5:251-254, 1998 38. Fujii K, Fukutomi T, Tsuda H, Akashi-Tanaka S, Nanasawa T, Kanai Y, Muramatsu Y. Microinvasive breast carcinoma with extensive involvement of level III axillary lymph nodes: a case report. Jpn J Clin Oncol, 28:47-49, 1998 39. Tsubosa Y, Fukutomi T, Tsuda H, Kanai Y, Akashi-Tanaka S, Nanasawa T, Linuma G, Ushio K. Breast cancer in Cowdens disease: a case report with review of the literature. Jpn J Clin Oncol, 28:42-46, 1998 40. Okano K, Fukutomi T, Tsuda H, Akashi-Tanaka S, Nanasawa T, Kanai Y. Local recurrence after conservative surgery without postoperative radiation for pure tubular carcinoma of the breast: a case report with reference to multifocality of tubular carcinoma. Breast Cancer, 5:201-204, 1998 41. Akashi-Tanaka S, Fukutomi T, Miyakawa K, Uchiyama N, Tsuda H. Diagnostic value of contrast-enhanced computed tomography for diagnosing the intraductal component of breast cancer. Breast Cancer Res Treat, 49:79-86, 1998 42. Sasako M, Mann GB, van de Velde CJ, Hirohashi S, Yoshida S. Report of the Eleventh International Symposium of the Foundation for Promotion of Cancer Research: basic and clinical research in gastric cancer. Jpn J Clin Oncol, 28:443-449, 1998 43. Sakao Y, Noro M, Sekine S, Nozue M, Hirohashi S, Itoh T, Noguchi M. Microsatellite instability and frameshift mutations in the bax gene in hereditary nonpolyposis colorectal carcinoma. Jpn J Cancer Res, 89:1020-1027, 1998 2. Biochemistry Division44. Nagao M, Ochiai M, Ushijima T, Watanabe M, Sugimura T, Nakagama H. Genetic determinant and environmental carcinogens. Mutat Res, 402:85-91, 1998 45. Yamada S, Shima H, Toyota M, Ushijima T, Kuramoto T, Serikawa T, Okada K, Sato K, Sugimura T, Nagao M, Nakagama H. Linkage mapping of the Bra, Brb and Brg genes for rat protein phosphatase 2A 55 kDa B-regulatory subunit isotypes. Jpn J Cancer Res, 89:1014-1019, 1998 46. Ochiai M, Ishida K, Ushijima T, Suzuki T, Sofuni T, Sugimura T, Nagao M. DNA adduct level induced by 2-amino-3,4-dimethylimidazo[4,5-f]-quinoline in Big BlueTM mice does not correlate with mutagenicity. Mutagenesis, 13:381-384, 1998 47. Ariumi Y, Ueda K, Masutani M, Copeland TD, Noda M, Hatanaka M, Shimotohno K. In vivo phosphorylation of poly(ADP-ribose) polymerase is independent of its activation. FEBS Lett, 436:288-292, 1998 48. Masutani M, Nozaki T, Nishiyama E, Ochiya T, Nakagama H, Wakabayashi K, Suzuki H, Sugimura T. Establishment of poly(ADP-ribose) polymerase-deficient mouse embryonic stem cell lines. Proc Jpn Acad, 74B:233-236, 1998 3. Experimental Pathology and Chemotherapy Division49. Tsuda H, Sekine K, Nakamura J, Ushida Y, Kuhara T, Takasuka N, Kim DJ, Asamoto M, Baba-Toriyama H, Moore MA, Nishino H, Kakizoe T. Inhibition of azoxymethane initiated colon tumor and aberrant crypt foci development by bovine lactoferrin administration in F344 rats. Adv Exp Med Biol, 443:273-284, 1998 50. Kim JM, Araki S, Kim DJ, Park CB, Takasuka N, Baba-Toriyama H, Ota T, Nir Z, Khachik F, Shimidzu N, Tanaka Y, Osawa T, Uraji T, Murakoshi M, Nishino H, Tsuda H. Chemopreventive effects of carotenoids and curcumins on mouse colon carcinogenesis after 1,2-dimethylhydrazine initiation. Carcinogenesis, 19:81-85, 1998 51. Ushida Y, Sekine K, Kuhara T, Takasuka N, Iigo M, Tsuda H. Inhibitory effects of bovine lactoferrin on intestinal polyposis in the ApcMin mouse. Cancer Lett, 134:141-145, 1998 52. Moore MA, Park CB, Tsuda H. Soluble and insoluble fiber influences on cancer development. Crit Rev Oncol Hematol, 27:229-242, 1998 53. Moore MA, Park CB, Tsuda H. Physical exercise: a pillar for cancer prevention? Eur J Cancer Prev, 7:177-193, 1998 54. Moore MA, Kunimoto T, Park CB, Takasuka N, Tsuda H. Cross-country comparisons provide evidence of a strong link between female lung and colon adenocarcinoma development. Cancer J, 11:259-262, 1998 55. Moore MA, Tsuda H. Co-ordination and ecology in practical cancer prevention. Eur J Cancer Prev, 7:409-415, 1998 56. Moore MA, Tsuda H. Chronically elevated proliferation as a risk factor for neoplasia. Eur J Cancer Prev, 7:353-385, 1998 57. Moore MA, Thamavit W, Tiwawech D, Ito N, Tsuda H. Modulation of dihydroxy-di-n-propylnitrosamine-induced liver lesion development in Opisthorchis-infected Syrian hamsters by praziquantel treatment in association with butylated hydroxyanisole or dehydroepiandrosterone administration. Jpn J Cancer Res, 89:1113-1117, 1998 58. Moore MA, Tsuda H. Insulin sensitizers: a promising group of cancer preventive agents? Cancer J, 11:72-75, 1998 59. Moore MA, Park CB, Tsuda H. Implications of the hyperinsulinaemia-diabetes-cancer link for preventive efforts. Eur J Cancer Prev, 7:89-107, 1998 60. Moore MA, Kunimoto T, Park CB, Takasuka N, Tsuda H. European country comparisons provide evidence of a link between colon cancer and adenocarcinoma development in the lung but not the oesophagus. Eur J Cancer Prev, 7:473-478, 1998 61. Asamoto M, Toriyama-Baba H, Krutovskikh V, Cohen SM, Tsuda H. Enhanced tumorigenicity of rat bladder squamous cell carcinoma cells after abrogation of gap junctional intercellular communication. Jpn J Cancer Res, 89:481-486, 1998 62. Asamoto M, Hori T, Baba-Toriyama H, Sano M, Takahashi S, Tsuda H, Shirai T. p16 gene overexpression in mouse bladder carcinomas. Cancer Lett, 127:9-13, 1998 63. Tsuda H, Iwase T, Matsumoto K, Ito M, Hirono I, Nishida Y, Takasuka N, Iwahori Y, Ota T, Kim DJ, Kadenbach B. Histogenetic stereological reconstruction of rat basophilic, clear, and oncocytic neoplastic renal cell lesions using carbonic anhydrase type II-PAS double-stained sections. Toxicol Pathol, 26:769-776, 1998 4. Biology Division64. Kohno T, Yokota J. PCR fingerprinting for detection of deleted or amplified sequences in human cancer. Methods Mol Biol, 92:267-272, 1998 65. Kohno T, Kawanishi M, Matsuda S, Ichikawa H, Takada M, Ohki M, Yamamoto T, Yokota J. Homozygous deletion and frequent allelic loss of the 21q11.1-q21.1 region including the ANA gene in human lung carcinoma. Genes Chromosom Cancer, 21:236-243, 1998 66. Hamada K, Kohno T, Kawanishi M, Ohwada S, Yokota J. Association of CDKN2A(p16)/CDKN2B(p15) alterations and homozygous chromosome arm 9p deletions in human lung carcinoma. Genes Chromosom Cancer, 22:232-240, 1998 67. Takei K, Kohno T, Hamada K, Takita J, Noguchi M, Matsuno Y, Hirohashi S, Uezato H, Yokota J. A novel tumor suppressor locus on chromosome 18q involved in the development of human lung cancer. Cancer Res, 58:3700-3705, 1998 68. Tanaka H, Shimizu M, Horikawa I, Kugoh H, Yokota J, Barrett JC, Oshimura M. Evidence for a putative telomerase repressor gene in the 3p14.2-p21.1 region. Genes Chromosom Cancer, 23:123-133, 1998 69. Kohno T, Kawanishi M, Inazawa J, Yokota J. Identification of CpG islands hypermethylated in human lung cancer by the arbitrarily primed-PCR method. Hum Genet, 102:258-264, 1998 70. Tomizawa Y, Nakajima T, Kohno T, Saito R, Yamaguchi N, Yokota J. Clinicopathological significance of Fhit protein expression in stage I non-small cell lung carcinoma. Cancer Res, 58:5478-5483, 1998 71. Reyes-Mugica M, Lin P, Yokota J, Reale MA. Status of deleted in colorectal cancer gene expression correlates with neuroblastoma metastasis. Lab Invest, 78:669-675, 1998 72. Takita J, Hayashi Y, Nakajima T, Adachi J, Tanaka T, Yamaguchi N, Ogawa Y, Hanada R, Yamamoto K, Yokota J. The p16 (CDKN2A) gene is involved in the growth of neuroblastoma cells and its expression is associated with prognosis of neuroblastoma patients. Oncogene, 17:3137-3143, 1998 73. Kohno T, Takahashi M, Manda R, Yokota J. Inactivation of the PTEN/MMACI/TEPI gene in human lung cancers. Gene Chromosom Cancer, 22:152-156, 1998 74. Takenoshita S, Tani M, Mogi A, Nagashima M, Nagamachi Y, Bennett WP, Hagiwara K, Harris CC, Yokota J. Mutation analysis of the Smad2 gene in human colon cancers using genomic DNA and intron primers. Carcinogenesis, 19:803-807, 1998 75. Taki T, Shibuya N, Taniwaki M, Hanada R, Morishita K, Bessho F, Yanagisawa M, Hayashi Y. ABI-1, a human homolog to mouse Ab1-interactor 1, fuses the MLL gene in acute myeloid leukemia with t(10;11)(p11.2;q23). Blood, 92:1125-1130, 1998 76. Iwase S, Furukawa Y, Horiguchi-Yamada J, Nemoto T, Takahara S, Kawano T, Sekikawa T, Ito K, Yamazaki Y, Kikuchi J, Morishita K, Yamada H. A novel variant of acute myelomonocytic leukemia carrying t(3;12)(q26;p13) with characteristics of 3q21q26 syndrome. Int J Hematol, 67:361-368, 1998 77. Lu H, Taya Y, Ikeda M, Levine AJ. Ultraviolet radiation, but not g radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389. Proc Natl Acad Sci U S A, 95:6399-6402, 1998 78. Banin S, Moyal L, Shieh S-Y, Taya Y, Anderson CW, Chessa L, Smorodinsky NI, Prives C, Reiss Y, Shiloh Y, Ziv Y. Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science, 281:1674-1677, 1998 79. Canman CE, Lim D-S, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, Siliciano JD. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science, 281:1677-1679, 1998 80. Khanna KK, Keating KE, Kozlov S, Scott S, Gatei M, Hobson K, Taya Y, Gabrielli B, Chan D, Lees-Miller SP, Lavin MF. ATM associates with and phosphorylates p53: mapping the region of interaction. Nat Genet, 20:398-400, 1998 81. Adachi J, Ookawa K, Kohno T, Tomizawa Y, Tsuchida S, Yokota J. Phenotypic alterations of small cell lung carcinoma induced by different levels of wild-type p53 expression. Cell Death Differ, 5:148-155, 1998 82. Yamabe Y, Shimamoto A, Goto M, Yokota J, Sugawara M, Furuichi Y. Sp1-mediated transcription of the Werner helicase gene is modulated by Rb and p53. Mol Cell Biol, 18:6191-6200, 1998 83. Tani M, Shinmura K, Kohno T, Shiroishi T, Wakana S, Kim S-R, Nohmi T, Kasai H, Takenoshita S, Nagamachi Y, Yokota J. Genomic structure and chromosomal localization of the mouse Ogg1 gene that is involved in the repair of 8-hydroxyguanine in DNA damage. Mamm Genome, 9:32-37, 1998 84. Kohno T, Shinmura K, Tosaka M, Tani M, Kim S-R, Sugimura H, Nohmi T, Kasai H, Yokota J. Genetic polymorphisms and alternative splicing of the hOGG1 gene, that is involved in the repair of 8-hydroxyguanine in damaged DNA. Oncogene, 16:3219-3225, 1998 85. Shinmura K, Kohno T, Kasai H, Koda K, Sugimura H, Yokota J. Infrequent mutations of the hOGG1 gene, that is involved in the excision of 8-hydroxyguanine in damaged DNA, in human gastric cancer. Jpn J Cancer Res, 89:825-828, 1998 86. Hashimoto Y, Shindo-Okada N, Tani M, Nagamachi Y, Takeuchi K, Shiroishi T, Toma H, Yokota J. Expression of the Elm1 gene, a novel gene of the CCN (connective tissue growth factor, Cyr61/Cef10, and neuroblastoma overexpressed gene) family, suppresses in vivo tumor growth and metastasis of K-1735 murine melanoma cells. J Exp Med, 187:289-296, 1998 87. Nagamachi Y, Tani M, Shimizu K, Tsuda H, Niitsu Y, Yokota J. Orthotopic growth and metastasis of human non-small cell lung carcinoma cells injected into the pleural cavity of nude mice. Cancer Lett, 127:203-209, 1998 88. Shinmura K, Tani M, Isogaki J, Wang Y, Sugimura H, Yokota J. RER phenotype and its associated mutations in familial gastric cancer. Carcinogenesis, 19:247-251, 1998 89. Kohno T, Takahashi M, Fukutomi T, Ushio K, Yokota J. Germline mutations of the PTEN/MMAC1 gene in Japanese patients with cowden disease. Jpn J Cancer Res, 89:471-474, 1998 90. Tomizawa Y, Adachi J, Kohno T, Yamaguchi N, Saito R, Yokota J. Identification and characterization of families with aggregation of lung cancer. Jpn J Clin Oncol, 28:192-195, 1998 5. Pharmacology Division91. Maruoka H, Ikarashi Y, Shinohara K, Miyata M, Sugimura T, Terada M, Wakasugi H. A novel monoclonal antibody permitting recognition of NKT cells in various mouse strains. Biochem Biophys Res Commun, 242:413-418, 1998 92. Nomoto T, Nishio K, Ishida T, Mori M, Saijo N. Characterization of a human small-cell lung cancer cell line resistant to a new water-soluble camptothecin derivative, DX-8951f. Jpn J Cancer Res, 89:1179-1186, 1998 93. Saijo N. New chemotherapeutic agents for the treatment of non-small cell lung cancer: the Japanese experience. Chest, 113:17s-23s, 1998 94. Yoshida M, Yokokura H, Hidaka H, Ikekawa T, Saijo N. Mechanism of antitumor action of PKC activator, gnidimacrin. Int J Cancer, 77:243-250, 1998 95. Fukuoka K, Narita N, Saijo N. Increased expression of sialyl Lewisx antigen is associated with distant metastasis in lung cancer patients: immunohistochemical study on bronchofiberscopic biopsy specimens. Lung Cancer, 20:109-116, 1998 96. Hama S, Heike Y, Naruse I, Takahashi M, Yoshioka H, Arita K, Kurisu K, Goldman CK, Curiel DT, Saijo N. Adenovirus-mediated p16 gene transfer prevents drug-induced cell death through G1 arrest in human glioma cells. Int J Cancer, 77:47-54, 1998 97. Nishio K, Fukuoka K, Saijo N. The role of MAP kinase in the taxane-induced cytotoxicity. In: Noboru K (ed), Hokkaido University Medical Library Series Vol. 37: Cytoskeleton and G-proteins in the Regulation of Cancer. Sapporo, Kokoku Printing Co. Ltd, pp 172-179, 1998 98. Saijo N, Nishio K, Yoshida M. Overcoming drug resistance in lung cancer. Oncology, 12:87-89, 1998 99. Chen Z-S, Mutoh M, Sumizawa T, Furukawa T, Haraguchi M, Tani A, Saijo N, Kondo T, Akiyama S. An active efflux system for heavy metals in cisplatin-resistant human KB carcinoma cells. Exp Cell Res, 240:312-320, 1998 100. Tanaka T, Uchiumi T, Kohno K, Tomonari A, Nishio K, Saijo N, Kondo T, Kuwano M. Glutathione homeostasis in human hepatic cells: overexpression of g-glutamylcysteine synthetase gene in cell lines resistant to buthionine sulfoximine, an inhibitor of glutathione synthesis. Biochem Biophys Res Commun, 246:398-403, 1998 101. Iwamoto Y, Nishio K, Fukumoto H, Yoshimatsu K, Yamakido M, Saijo N. Preferential binding of E7010 to murine b3-tubulin and decreased b3-tubulin in E7010-resistant cell lines. Jpn J Cancer Res, 89:954-962, 1998 102. Kasai T, Ohe Y, Nishio K, Kunitoh H, Tamura T, Sekine I, Kubota K, Yamamoto N, Nakamura Y, Shinkai T, Kodama T, Saijo N. Factors that influence the eligibility of cases for inclusion in clinical trials. Jpn J Clin Oncol, 28:214-221, 1998 103. Kunitoh H, Saijo N, Furuse K, Noda K, Ogawa M. Neuromuscular toxicities of paclitaxel 210 mg m-2 by 3-hour infusion. Br J Cancer, 77:1686-1688, 1998 104. Yokoyama A, Kurita Y, Saijo N, Tamura T, Noda K, Shimokata K, Matsuda T. Dose-finding study of irinotecan and cisplatin plus concurrent radiotherapy for unresectable stage III non-small-cell lung cancer. Br J Cancer, 78:257-262, 1998 105. Kojima S, Matsuki O, Nomura T, Shimura N, Kubodera A, Yamaoka K, Tanooka H, Wakasugi H, Honda Y, Honda S, Sasaki T. Localization of glutathione and induction of glutathione synthesis-related proteins in mouse brain by low doses of g-rays. Brain Res, 808:262-269, 1998 106. Kojima S, Matsuki O, Nomura T, Kubodera A, Honda Y, Honda S, Tanooka H, Wakasugi H, Yamaoka K. Induction of mRNAs for glutathione synthesis-related proteins in mouse liver by low doses of g-rays. Biochim Biophys Acta, 1381:312-318, 1998 6. Biophysics Division107. Mishima K, Higashiyama S, Asai A, Yamaoka K, Nagashima Y, Taniguchi N, Kitanaka C, Kirino T, Kuchino Y. Heparin-binding epidermal growth factor-like growth factor stimulates mitogenic signaling and is highly expressed in human malignant gliomas. Acta Neuropathol (Berl), 96:322-328, 1998 108. Komatsu S, Nishii W, Sasaki H, Muramatsu T, Tanokura M. Substrate specificity of non-pepsin-type acid proteinase, Aspergillus niger proteinase A. Adv Exp Med Biol, 436:345-348, 1998 109. Hanaki K, Odawara T, Nakajima N, Shimizu YK, Nozaki C, Mizuno K, Muramatsu T, Kuchino Y, Yoshikura H. Two different reactions involved in the primer/template-independent polymerization of dATP and dTTP by Taq DNA polymerase. Biochem Biophys Res Commun, 244:210-219, 1998 110. Kaneko M, Inoue F. The sensitivity to DNA single strand breakage in mitochondria, but not in nuclei, of Chinese hamster V79 and variant cells correlates with their cellular sensitivity to hydrogen peroxide. Toxicol Lett, 99:15-22, 1998 111. Ito S, Inoue K, Yanagisawa N, Kaneko M, Hayashi J. Long-term postmortem survival of mitochondrial genomes in mouse synaptosomes and their rescue in a mitochondrial DNA-less mouse cell line. Biochem Biophys Res Commun, 247:432-435, 1998 112. Yoshinobu J, Kawai M, Imamura I, Marumo F, Suzuki R, Ozaki H, Aoki M, Masuda S, Aida M. Direct observation of molecule-substrate antibonding states near the Fermi level in Pd(110)-c(4 x 2)-benzene. Phys Rev Lett, 79:3942-3945, 1997 113. Tsuboi M, Ezaki Y, Aida M, Suzuki M, Yimit A, Ushizawa K, Ueda T. Raman scattering tensors of tyrosine. Biospectroscopy, 4:61-71, 1998 114. Nishimura K, Naito A, Tuzi S, Hazime S, Hashimoto C, Aida M. Determination of the three-dimensional structure of crystalline Leu-enkephalin dihydrate based on six sets of accurately determined interatomic distances from 13C-REDOR NMR and the conformation-dependent 13C chemical shifts. J Phys Chem B, 102:7476-7483, 1998 115. Aida M, Inoue F, Kaneko M, Dupuis M. An ab initio MO study on fragmentation reaction mechanism of thymine dimer radical cation. J Am Chem Soc, 119:12274-12279, 1997 116. Yamataka H, Aida M. An ab initio MO study on the hydrolysis of methyl chloride with explicit consideration of 13 water molecules. Chem Phys Lett, 289:105-109, 1998 117. Aida M, Yamataka H, Dupuis M. Ab initio molecular dynamics simulations on the hydrolysis of methyl chloride with explicit consideration of three water molecules. Chem Phys Lett, 292:474-480, 1998 7. Growth Factor Division118. Ohkura N, Maruyama K, Tsukada T, Hosono T, Yamaguchi K. The NGFI-B family: orphan nuclear receptors of the steroid/thyroid receptor superfamily. J Reprod Dev, 44:321-335, 1998 119. Maruyama K, Tsukada T, Ohkura N, Bandoh S, Hosono T, Yamaguchi K. The NGFI-B subfamily of the nuclear receptor superfamily (Review). Int J Oncol, 12:1237-1243, 1998 120. Ohkura N, Ito M, Tsukada T, Sasaki K, Yamaguchi K, Miki K. Alternative splicing generates isoforms of human neuron-derived orphan receptor-1 (NOR-1) mRNA. Gene, 211:79-85, 1998 121. Miyakoshi J, Tsukada T, Tachiiri S, Bandoh S, Yamaguchi K, Takebe H. Enhanced NOR-1 gene expression by exposure of Chinese hamster cells to high-density 50 Hz magnetic fields. Mol Cell Biochem, 181:191-195, 1998 122. Hitomi J, Kimura T, Kusumi E, Nakagawa S, Kuwabara S, Hatakeyama K, Yamaguchi K. Novel S100 proteins in human esophageal epithelial cells: CAAF1 expression is associated with cell growth arrest. Arch Histol Cytol, 61:163-178, 1998 123. Suginaka R, Izui R, Inoue J, Muraoka Y, Yamaguchi K, Otsuka M, Umezawa K. Induction of apoptosis in human pancreatic carcinoma cells by a synthetic bleomycin-like ligand. Jpn J Cancer Res, 89:947-953, 1998 124. Kawasaki H, Takayama J, Nagasaki K, Yamaguchi K, Ohira M. Hypercalcemia in children with rhabdomyosarcoma. J Pediatr Hematol Oncol, 20:327-329, 1998 125. Okada S, Okusaka T, Ishii H, Kyogoku A, Yoshimori M, Kajimura N, Yamaguchi K, Kakizoe T. Elevated serum interleukin-6 levels in patients with pancreatic cancer. Jpn J Clin Oncol, 28:12-15, 1998 126. Kishi M, Tsukada T, Shimizu S, Futami H, Ito Y, Kanbe M, Obara T, Yamaguchi K. A large germline deletion of the MEN1 gene in a family with multiple endocrine neoplasia type 1. Jpn J Cancer Res, 89:1-5, 1998 127. Egawa S, Futami H, Takasaki K, Iihara M, Okamoto T, Kanbe M, Ohi T, Saio Y, Miyauchi A, Takiyama Y, Koga M, Miyanaga K, Inoue K, Mitsuyama S, Nomura Y, Takei H, Mugiya S, Ishida O, Zeze F, Shakutsui S, Inoue H, Oya H, Yoshimura A, Ishizuka S, Tsujino T, Obara T, Yamaguchi K. Genotype-phenotype correlation of patients with multiple endocrine neoplasia type 2 in Japan. Jpn J Clin Oncol, 28:590-596, 1998 128. Futami H. DNA testing for more sophisticated clinical management of multiple endocrine neoplasia type 2 (MEN 2). Jpn J Clin Oncol, 28:588-589, 1998 8. Radiobiology Division129. Gamou T, Kitamura E, Hosoda F, Shimizu K, Shinohara K, Hayashi Y, Nagase T, Yokoyama Y, Ohki M. The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family. Blood, 91:4028-4037, 1998 130. Morohoshi F, Ootsuka Y, Arai K, Ichikawa H, Mitani S, Munakata N, Ohki M. Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes. Gene, 221:191-198, 1998 131. Kitabayashi I, Yokoyama A, Shimizu K, Ohki M. Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation. EMBO J, 17:2994-3004, 1998 132. Kitabayashi I, Ida K, Morohoshi F, Yokoyama A, Mitsuhashi N, Shimizu K, Nomura N, Hayashi Y, Ohki M. The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1. Mol Cell Biol, 18:846-858, 1998 133. Ikegawa S, Ohashi H, Hosoda F, Fukushima Y, Ohki M, Nakamura Y. Pseudoachondroplasia with de novo deletion [del(11)(q21q22.2)]. Am J Med Genet, 77:356-359, 1998 134. Eguchi-Ishimae M, Eguchi M, Tanaka K, Hamamoto K, Ohki M, Ueda K, Kamada N. Fluorescence in situ hybridization analysis of 12;21 translocation in Japanese childhood acute lymphoblastic leukemia. Jpn J Cancer Res, 89:783-788, 1998 135. Munakata N, Ono M, Watanabe S. Monitoring of solar-UV exposure among schoolchildren in five Japanese cities using spore dosimeter and UV-coloring labels. Jpn J Cancer Res, 89:235-245, 1998 9. Cancer Information and Epidemiology Division136. Noda N, Sasako M, Yamaguchi N, Nakanishi Y. Ignoring small lymph nodes can be a major cause of staging error in gastric cancer. Br J Surg, 85:831-834, 1998 137. Kinjo Y, Cui Y, Akiba S, Watanabe S, Yamaguchi N, Sobue T, Mizuno S, Beral V. Mortality risks of oesophageal cancer associated with hot tea, alcohol, tobacco and diet in Japan. J Epidemiol, 8:235-243, 1998 138. Ye W, Sobue T, Lee VS, Tanooka H, Mifune M, Suyama A, Koga T, Morishima H, Kondo S. Mortality and cancer incidence in Misasa, Japan, a spa area with elevated radon levels. Jpn J Cancer Res, 89:789-796, 1998 139. Kawahara M, Ushijima S, Kamimori T, Kodama N, Ogawara M, Matsui K, Masuda N, Takada M, Sobue T, Furuse K. Second primary tumours in more than 2-year disease-free survivors of small-cell lung cancer in Japan: the role of smoking cessation. Br J Cancer, 78:409-412, 1998 140. Watanabe S, Yamaguchi M, Sobue T, Takahashi T, Miura T, Arai Y, Mazur W, Whl K, Adlercreutz H. Pharmacokinetics of soybean isoflavones in plasma, urine and feces of men after ingestion of 60 g baked soybean powder (kinako). J Nutr, 128:1710-1715, 1998 141. Yamaguchi N. Role of epidemiology in carcinogenic risk assessment. Rev Toxicol, 2:53-58, 1998 142. Shimoyama M, Fukuda H, Saijo N, Yamaguchi N. Japan Clinical Oncology Group (JCOG). Jpn J Clin Oncol, 28:158-162, 1998 143. Sekine I, Fukuda H, Kunitoh H, Saijo N. Cancer chemotherapy in the elderly. Jpn J Clin Oncol, 28:463-473, 1998 144. Abe K, Wakao F, Oyama H, Mizushima H, Shinkai T, Ishikawa KB, Watanabe T, Moriyama N, Yamaguchi N. Information technology at the National Cancer Center. Jpn J Clin Oncol, 28:527-530, 1998 145. Nagata H, Mizushima H. A remote collaboration system for telemedicine using the internet. J Telemed Telecare, 4:89-94, 1998 146. Nagata H, Mizushima H. World Wide Microscope: new concept of internet telepathology microscope and implementation of the prototype. In: Cesnik B, McCray A, Scherrer J-R (eds), MEDINFO 98. Amsterdam, IOS Press, pp 286-289, 1998 147. Nakagawa S, Okamura K, Honjo T, Yamaoka K, Ishikawa KB, Ohno H, Yamaguchi N. Evaluation of the multimedia-multicast-mobile-terminal for hospital patient care. In: Srimani P, Fayad ME (eds), Proceedings of the 12th International Conference on Information Networking (Tokyo, Japan, January 21-23, 1998). Los Alamitos, CA, IEEE Computer Society, pp 369-374, 1998 10. Virology and Glycobiology Division148. Mizutani T, Ikeda M, Saito S, Sugiyama K, Shimotohno K, Kato N. Detection of negative-stranded hepatitis C virus RNA using a novel strand-specific reverse transcription-polymerase chain reaction. Virus Res, 53:209-214, 1998 149. Mizutani T, Ikeda M, Saito S, Sugiyama K, Shimotohno K, Kato N. Single-step reverse transcription-polymerase chain reaction for the detection of hepatitis C virus RNA. Microbiol Immunol, 42:549-553, 1998 150. Ikeda M, Sugiyama K, Tanaka T, Tanaka K, Sekihara H, Shimotohno K, Kato N. Lactoferrin markedly inhibits hepatitis C virus infection in cultured human hepatocytes. Biochem Biophys Res Commun, 245:549-553, 1998 151. Tanaka T, Shimotohno K. Detection and molecular cloning of the extreme 3'-end of HCV. Methods Mol Med, 19:373-380, 1998 152. Kato N, Ikeda M, Sugiyama K, Mizutani T, Tanaka T, Shimotohno K. Hepatitis C virus population dynamics in human lymphocytes and hepatocytes infected in vitro. J Gen Virol, 79:1859-1869, 1998 153. Ikeda M, Sugiyama K, Mizutani T, Tanaka T, Tanaka K, Sekihara H, Shimotohno K, Kato N. Human hepatocyte clonal cell lines that support persistent replication of hepatitis C virus. Virus Res, 56:157-167, 1998 154. Ibe M, Sakaguchi T, Tanaka K, Saito S, Yokota S, Tanaka T, Shimotohno K, Chujoh Y, Shiratori Y, Omata M, Miwa K, Takiguchi M. Identification and characterization of a cytotoxic T cell epitope of hepatitis C virus presented by HLA-B*3501 in acute hepatitis. J Gen Virol, 79:1735-1744, 1998 155. Ishii A, Ohta M, Watanabe Y, Matsuda K, Ishiyama K, Sakoe K, Nakamura M, Inokuchi J, Sanai Y, Saito M. Expression cloning and functional characterization of human cDNA for ganglioside GM3 synthase. J Biol Chem, 273:31652-31655, 1998 156. Ohta M, Sakai T, Saga Y, Aizawa S, Saito M. Suppression of hematopoietic activity in tenascin-C-deficient mice. Blood, 91:4074-4083, 1998 11. Cancer Prevention Division157. Oguri A, Shiozawa T, Terao Y, Nukaya H, Yamashita J, Ohe T, Sawanishi H, Katsuhara T, Sugimura T, Wakabayashi K. Identification of a 2-phenylbenzotriazole (PBTA)-type mutagen, PBTA-2, in water from the Nishitakase River in Kyoto. Chem Res Toxicol, 11:1195-1200, 1998 158. Shiozawa T, Muraoka K, Nukaya H, Ohe T, Sawanishi H, Oguri A, Wakabayashi K, Sugimura T, Terao Y. Chemical synthesis of a novel aromatic amine mutagen isolated from water of the Nishitakase River in Kyoto and a possible route of its formation. Chem Res Toxicol, 11:375-380, 1998 159. Totsuka Y, Hada N, Matsumoto K, Kawahara N, Murakami Y, Yokoyama Y, Sugimura T, Wakabayashi K. Structural determination of a mutagenic aminophenylnorharman produced by the co-mutagen norharman with aniline. Carcinogenesis, 19:1995-2000, 1998 160. Oguri A, Suda M, Totsuka Y, Sugimura T, Wakabayashi K. Inhibitory effects of antioxidants on formation of heterocyclic amines. Mutat Res, 402:237-245, 1998 161. Mori T, Nakagawa A, Kobayashi N, Hashimoto MW, Wakabayashi K, Shimoi K, Kinae N. 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) sensitizes mammalian cells to UV radiation by causing the S-phase arrest, not by inhibiting the repair of DNA damage as observed in Escherichia coli. J Radiat Res, 39:21-33, 1998 162. Okumura A, Sugie S, Wakabayashi K, Mori H. Rapid induction of replication DNA synthesis in response to 2-amino-3, 4-dimethylimidazo [4,5-f] quinoline in rat hepatocytes. Environ Mutagen Res, 20:35-40, 1998 163. Itoh S, Hirai T, Totsuka Y, Takagi H, Tashiro Y, Wada K, Wakabayashi K, Shibutani S, Yoshizawa I. Identification of estrogen-modified nucleosides from calf thymus DNA reacted with 6-hydroxyestrogen 6-sulfates. Chem Res Toxicol, 11:1312-1318, 1998 164. Watanabe T, Ishida S, Minami H, Kasai T, Ogawa S, Wakabayashi K, Hirayama T. Identification of 1,6- and 1,8-dinitropyrene isomers as major mutagens in organic extracts of soil from Osaka, Japan. Chem Res Toxicol, 11:1501-1507, 1998 165. Wakabayashi K, Sugimura T. Heterocyclic amines formed in the diet: carcinogenicity and its modulation by dietary factors. J Nutr Biochem, 9:604-612, 1998 166. Okada S, Sato T, Okusaka T, Ishii H, Ikeda M, Nakasuka H, Kosakamoto H, Yoshimori M, Wakabayashi K. Past exposure to hepatitis B virus as a risk factor for hepatocellular carcinoma in patients with chronic liver disease. Br J Cancer, 77:2028-2031, 1998 167. Wakabayashi K. Dietary mutagens and carcinogens: heterocyclic amines. In: Carroll KK (ed), Current Perspectives on Nutrition and Health. Montreal, Kingston, McGill-Queens University Press, pp 215-226, 1998 168. Fukutake M, Nakatsugi S, Isoi T, Takahashi M, Ohta T, Mamiya S, Taniguchi Y, Sato H, Fukuda K, Sugimura T, Wakabayashi K. Suppressive effects of nimesulide, a selective inhibitor of cyclooxygenase-2, on azoxymethane-induced colon carcinogenesis in mice. Carcinogenesis, 19:1939-1942, 1998 169. Okajima E, Denda A, Ozono S, Takahama M, Akai H, Sasaki Y, Kitayama W, Wakabayashi K, Konishi Y. Chemopreventive effects of nimesulide, a selective cyclooxygenase-2 inhibitor, on the development of rat urinary bladder carcinomas initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine. Cancer Res, 58:3028-3031, 1998 170. Onozawa M, Fukuda K, Ohtani M, Akaza H, Sugimura T, Wakabayashi K. Effects of soybean isoflavones on cell growth and apoptosis of the human prostatic cancer cell line LNCaP. Jpn J Clin Oncol, 28:360-363, 1998 171. Takahashi M, Fukuda K, Sugimura T, Wakabayashi K. b-catenin is frequently mutated and demonstrates altered cellular location in azoxymethane-induced rat colon tumors. Cancer Res, 58:42-46, 1998 172. Ohata T, Fukuda K, Murakami A, Ohigashi H, Sugimura T, Wakabayashi K. Inhibition by 1'-acetoxychavicol acetate of lipopolysaccharide- and interferon-g-induced nitric oxide production through suppression of inducible nitric oxide synthase gene expression in RAW264 cells. Carcinogenesis, 19:1007-1012, 1998 173. Watanabe M, Kono T, Koyama K, Sugimura T, Wakabayashi K. Purification of pierisin, an inducer of apoptosis in human gastric carcinoma cells, from cabbage butterfly, Pieris rapae. Jpn J Cancer Res, 89:556-561, 1998 12. Genetics Division174. Tokuhara M, Hirai M, Atomi Y, Terada M, Katoh M. Molecular cloning of human Frizzled-6. Biochem Biophys Res Commun, 243:622-627, 1998 175. Sasaki H, Ishizuka T, Muto M, Nezu M, Nakanishi Y, Inagaki Y, Watanabe H, Watanabe H, Terada M. Presence of Streptococcus anginosus DNA in esophageal cancer, dysplasia of esophagus, and gastric cancer. Cancer Res, 58:2991-2995, 1998 176. Fiddes RJ, Campbell DH, Janes PW, Sivertsen SP, Sasaki H, Wallasch C, Daly RJ. Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3. J Biol Chem, 273:7717-7724, 1998 177. Ide H, Saito-Ohara F, Ohnami S, Osada Y, Ikeuchi T, Yoshida T, Terada M. Assignment of the BMPR1A and BMPR1B genes to human chromosome 10q22.3 and 4q23q24 by in situ hybridization and radiation hybrid mapping. Cytogenet Cell Genet, 81:285-286, 1998 178. Takahama Y, Ochiya T, Sasaki H, Baba-Toriyama H, Konishi H, Nakano H, Terada M. Molecular cloning and functional analysis of cDNA encoding a rat leukemia inhibitory factor: towards generation of pluripotent rat embryonic stem cells. Oncogene, 16:3189-3196, 1998 179. Konishi H, Ochiya T, Sakamoto H, Tsukamoto M, Yasuda Y, Muto T, Sugimura T, Terada M. Effective prevention of thrombocytopenia using adenovirus-mediated transfer of HST-1/FGF-4 gene: in vivo and in vitro studies. Leukemia, 11:530-532, 1997 180. Konishi H, Ochiya T, Chester KA, Begent RHJ, Muto T, Sugimura T, Terada M. Targeting strategy for gene delivery to carcinoembryonic antigen-producing cancer cells by retrovirus displaying a single-chain variable fragment antibody. Hum Gene Ther, 9:235-248, 1998 181. Matsumoto N, Laub F, Aldabe R, Zhang W, Ramirez F, Yoshida T, Terada M. Cloning the cDNA for a new human zinc finger protein defines a group of closely related Krppel-like transcription factors. J Biol Chem, 273:28229-28237, 1998 13. Oncogene Division182. Murakami Y, Sekiya T. Accumulation of genetic alterations and their significance in each primary human cancer and cell line. Mutat Res, 400:421-437, 1998 183. Kijima G, Murakami Y, Ohuchi N, Satomi S, Sekiya T. Nonsense mutation at codon 63 of the BRCA1 gene in Japanese breast cancer patients. Jpn J Cancer Res, 89:837-841, 1998 184. Shigyo M, Sugano K, Fukayama N, Taniguchi T, Tobisu K, Fujimoto H, Doi N, Niwakawa M, Shimamura K, Tsukamoto T, Sekiya T, Kakizoe T. Allelic loss on chromosome 9 in bladder cancer tissues and urine samples detected by blunt-end single-strand DNA conformation polymorphism. Int J Cancer, 78:425-429, 1998 185. Maekawa M, Sugano K, Sano H, Miyazaki S, Ushiama M, Fujita S, Gotoda T, Yokota T, Ohkura H, Kakizoe T, Sekiya T. Increased expression of cyclooxygenase-2 to -1 in human colorectal cancers and adenomas, but not in hyperplastic polyps. Jpn J Clin Oncol, 28:421-426, 1998 186. Saito T, Kaneko A, Muramatsu Y, Inomata M, Murakami Y, Den S, Gotanda J, Yokokawa N, Hiraga K, Carney E, Lnnqvist P-A, Carlsson C. Difficult tracheal intubation in patients with retinoblastoma caused by 13q deficiency. Jpn J Clin Oncol, 28:507-510, 1998 187. Malkhosyan S, Yasuda J, Soto JL, Sekiya T, Yokota J, Perucho M. Molecular karyotype (amplotype) of metastatic colorectal cancer by unbiased arbitrarily primed PCR DNA fingerprinting. Proc Natl Acad Sci U S A, 95:10170-10175, 1998 188. Kawakami K, Yasuda J, Shiraishi M, Kayama T, Doi K, Perucho M, Sekiya T. Detection of DNA abnormalities by arbitrarily primed PCR fingerprinting: allelic losses in chromosome 10q in lung cancers. Biochem Biophys Res Commun, 251:153-157, 1998 189. Kon H, Sonoda Y, Kumabe T, Yoshimoto T, Sekiya T, Murakami Y. Structural and functional evidence for the presence of tumor suppressor genes on the short arm of chromosome 10 in human gliomas. Oncogene, 16:257-263, 1998 190. Murakami Y, Nobukuni T, Tamura K, Maruyama T, Sekiya T, Arai Y, Gomyou H, Tanigami A, Ohki M, Cabin D, Frischmeyer P, Hunt P, Reeves RH. Localization of tumor suppressor activity important in nonsmall cell lung carcinoma on chromosome 11q. Proc Natl Acad Sci U S A, 95:8153-8158, 1998 191. Shiraishi M, Oates AJ, Li X, Hosoda F, Ohki M, Alitalo T, Lerman LS, Sekiya T. The isolation of CpG islands from human chromosomal regions 11q13 and Xp22 by segregation of partly melted molecules. Nucleic Acids Res, 26:5544-5550, 1998 14. Carcinogenesis Division192. Nagao M, Sugimura T. Multiple steps in carcinogenesis, multiple carcinogenic factors, and multiple primary tumors: can we develop an appropriate response for cancer prevention? Drug Metab Rev, 30:405-419, 1998 193. Nagao M, Sugimura T. Mammary cancer. In: Kitchin KT (ed), Carcinogenicity: Testing, Predicting, and Interpreting Chemical Effectts. New York, Basel, Marcel Dekker, Inc., pp 563-580, 1998 194. Ushijima T, Nagao M. New approaches in genotyping and mapping. In: Tommaso DA (ed), Human Polygenic Diseases: Animal Models. Berks, Harwood Academic Publishers, pp 231-246, 1998 195. Toyota M, Ushijima T, Suzui M, Murakumo Y, Imai K, Sugimura T, Matsuyama M. Generation of polymorphic markers tightly linked to the thymus enlargement loci by phenotype-directed representational difference analysis. Mamm Genome, 9:735-739, 1998 196. Dashwood RH, Suzui M, Nakagama H, Sugimura T, Nagao M. High frequency of b-catenin (Ctnnb1) mutations in the colon tumors induced by two heterocyclic amines in the F344 rat. Cancer Res, 58:1127-1129, 1998 197. Nagao M, Fujita H, Ochiai M, Wakabayashi K, Sofuni T, Matsushima T, Sugimura T, Ushijima T. No direct correlation between mutant frequencies and cancer incidence induced by MeIQ in various organs of Big Blue mice. Mutat Res, 400:251-257, 1998 198. Ramsey MJ, Nagao M, Inoue R, Fujita H, Matsushima T, Tucker JD. Chromosome aberrations induced in mice by chronic feeding of 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ). Food Chem Toxicol, 36:467-474, 1998 199. Haneji T, Morimoto H, Morimoto Y, Shirakawa S, Kobayashi S, Kaneda C, Shima H, Nagao M. Subcellular localization of protein phosphatase type 1 isotypes in mouse osteoblastic cells. Biochem Biophys Res Commun, 248:39-43, 1998 200. Kotani H, Ito M, Hamaguchi T, Ichikawa K, Nakano T, Shima H, Nagao M, Ohta N, Furuichi Y, Takahashi T, Umekawa H. The d isoform of protein phosphatase type 1 is localized in nucleolus and dephosphorylates nucleolar phosphoproteins. Biochem Biophys Res Commun, 249:292-296, 1998 16. Section for Studies on Host-immune Response201. Ikarashi Y, Maruoka H, Shinohara K, Sugimura T, Terada M, Wakasugi H. Mouse NK1.1+ cytotoxic T cells can be generated by IL-2 exposure from lymphocytes which express an intermediate level of T cell receptor. Immunol Lett, 61:165-173, 1998 202. Shinohara K, Miyazaki K, Noda N, Saitoh D, Terada M, Wakasugi H. Gastric diseases related to Helicobacter pylori and Epstein-Barr virus infection. Microbiol Immunol, 42:415-421, 1998 17. Pathology Division, East203. Hasebe T, Imoto S, Ogura T, Mukai K. Significance of basic fibroblast growth factor and fibroblast growth factor receptor protein expression in the formation of fibrotic focus in invasive ductal carcinoma of the breast. Jpn J Cancer Res, 88:877-885, 1997 204. Hasebe T, Tsuda H, Hirohashi S, Shimosato Y, Tsubono Y, Yamamoto H, Mukai K. Fibrotic focus in infiltrating ductal carcinoma of the breast: a significant histopathological prognostic parameter for predicting the long-term survival of the patients. Breast Cancer Res Treat, 49:195-208, 1998 205. Hasebe T, Imoto S, Sasaki S, Mukai K. A proposal for a new histological classification scheme for predicting short-term tumor recurrence and death in patients with invasive ductal carcinoma of the breast. Jpn J Cancer Res, 89:1358-1373, 1998 206. Suzuki K, Takahashi K, Yoshida J, Nishimura M, Yokose T, Nishiwaki Y, Nagai K. Synchronous double primary lung carcinomas associated with multiple atypical adenomatous hyperplasia. Lung Cancer, 19:131-139, 1998 207. Yoshida J, Nagai K, Yokose T, Takahashi K, Nishimura M, Goto K, Nishiwaki Y. Primary peripheral lung carcinoma smaller than 1 cm in diameter. Chest, 114:710-712, 1998 208. Asakage T, Yokose T, Mukai K, Tsugane S, Tsubono Y, Asai M, Ebihara S. Tumor thickness predicts cervical metastasis in patients with Stage I/II carcinoma of the tongue. Cancer, 82:1443-1448, 1998 209. Imoto S, Ohkura H, Sugano K, Sasaki Y, Ito K, Igarashi T, Ohtsu T, Fujii H, Minami H, Hasebe T, Mukai K. Determination of cytosol c-erbB-2 protein in breast cancer by sandwich enzyme immunoassay. Jpn J Clin Oncol, 28:92-96, 1998 210. Sekine I, Kodama T, Yokose T, Nishiwaki Y, Suzuki K, Goto K, Nagai K, Kuriyama T. Rare pulmonary tumors: a review of 32 cases. Oncology, 55:431-434, 1998 211. Boku N, Chin K, Hosokawa K, Ohtsu A, Tajiri H, Yoshida S, Yamao T, Kondo H, Shirao K, Shimada Y, Saito D, Hasebe T, Mukai K, Seki S, Saito H, Johnston PG. Biological markers as a predictor for response and prognosis of unresectable gastric cancer patients treated with 5-fluorouracil and cis-platinum. Clin Cancer Res, 4:1469-1474, 1998 212. Yokose T, Doy M, Kakiki M, Horie T, Matsuzaki Y, Mukai K. Expression of cytochrome P450 3A4 in foveolar epithelium with intestinal metaplasia of the human stomach. Jpn J Cancer Res, 89:1028-1032, 1998 213. Asami H, Ito Y, Suzuki-Aida J, Okada Y, Takagi K, Koike N, Sakamoto A, Yokose T. Small cell undifferentiated carcinoma of the urinary bladder: a cytodiagnostic case report of its variant type. Pathol Int, 47:876-882, 1997 214. Fukushima N, Mukai K. Ovarian-type stroma of pancreatic mucinous cystic tumor expresses smooth muscle phenotype. Pathol Int, 47:806-808, 1997 215. Nishimura R, Hasebe T, Imoto S, Mukai K. Malignant phyllodes tumour with a noninvasive ductal carcinoma component. Virchows Arch, 432:89-93, 1998 216. Imoto S, Hasebe T. Intracystic papillary carcinoma of the breast in male: case report and review of the Japanese literature. Jpn J Clin Oncol, 28:517-520, 1998 217. Kawasaki H, Yoshida J, Yokose T, Suzuki K, Nagai K, Hojo F, Kodama T, Nishiwaki Y. Primary unknown cancer in pulmonary hilar lymph node with spontaneous transient regression: report of a case. Jpn J Clin Oncol, 28:405-409, 1998 218. Suzuki K, Yoshida J, Takahashi K, Nishimura M, Kawasaki H, Yokose T, Nagai K. Isolated mediastinal Hodgkins disease mimicking thymoma: report of a case. Surg Today, 28:213-216, 1998 219. Sekine I, Sasaki Y, Hasebe T, Umeda T, Mukai K. Coxalgia as the initial symptom in Hodgkins disease: a case report. Jpn J Clin Oncol, 27:353-356, 1997 220. Yokose T, Kodama T, Matsuno Y, Shimosato Y, Nishimura M, Mukai K. Low-grade B cell lymphoma of mucosa-associated lymphoid tissue in the thymus of a patient with rheumatoid arthritis. Pathol Int, 48:74-81, 1998 221. Furukawa H, Kosuge T, Kanai Y, Mukai K. Epidermoid cyst in an intrapancreatic accessory spleen: CT and pathologic findings. AJR Am J Roentgenol, 171:271, 1998 222. Sekine I, Sasaki Y, Hasebe T, Mukai K, Kinoshita T, Amano A, Tobisu K. Recurrence of a germ cell tumor 12 years after initial treatment: a case report. Jpn J Clin Oncol, 28:50-53, 1998 223. Konishi K, Tajiri H, Fujii T, Boku N, Ohtu A, Yoshida S, Konishi M, Hasebe T, Mukai K, Makino R. Hereditary nonpolyposis colorectal cancer associated with duodenal carcinoma: a case report. Jpn J Clin Oncol, 28:289-293, 1998 224. Furukawa H, Mizuguchi Y, Kanai Y, Mukai K. Metastatic renal cell carcinoma to the gallbladder: color doppler sonography and CT findings. AJR Am J Roentgenol, 169:1466-1467, 1997 225. Furukawa H, Kosuge T, Mukai K, Iwata R, Kanai Y, Shimada K, Yamamoto J, Ushio K. Helical computed tomography in the diagnosis of portal vein invasion by pancreatic head carcinoma. Arch Surg, 133:61-65, 1998 226. Iwasaki M, Furuse J, Yoshino M, Ryu M, Moriyama N, Mukai K. Sonographic appearances of small hepatic nodules without tumor stain on contrast-enhanced computed tomography and angiography. J Clin Ultrasound, 26:303-307, 1998 227. 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