Project Index Arranged by Category

Chemical and radiation carcinogenesis

Linkage Mapping of the Genetic Susceptibility to ACF Formation by PhIP

　 on Rat Chromosome 16 6

Carcinogenicity of PhIP in Various Mice Strains 6

Susceptibility of Chemical Carcinogens of Human c-Ha-ras

　Proto-oncogene Transgenic Rats 8

Promoting Effect of Caffeine on PhIP Colon Carcinogenesis 9

Mechanisms and Histogenesis of Carcinogenesis and Models for

　Environmental Carcinogen Assay 9

Monitoring of Solar-UV Exposure with Biodosimetry 19

Mutagens in Water from the Nishitakase River 24

Comutagenic Action of Norharman 24

Altered Gene Expression in Rat Colon Tumors Induced by AOM 25

Stomach Cancer Susceptibility and the Rat Genome 30

Heterocyclic Amine Carcinogenesis 30

Serine/Threonine Protein Phosphatases in Carcinogenesis 31

Culture of Rat ES Cells 32

Chemoprevention

Chemopreventive Effects of Dietary Factors on Tumor Development 8

Inhibitory Effects of Bovine Lactoferrin on Colon Carcinoma 26 Lung

　Metastasis 9

Suppression of Colon and Urinary Bladder Carcinogenesis by a Selective

　Inhibitor of Cyclooxygenase-2 (COX-2), Nimesulide 24

Infection, inflammation and carcinogenesis

Efficient Detection and Inhibition by Lactoferrin of HCV Infection, and

　Molecular Cloning of its Extreme 3'-End 22

Cell Tropism, Persistent Replication, and a Cytotoxic T Cell Epitope of

HCV 22 Upper GI Tract Cancers and Streptococcus anginosus Infection

　26

Implication of Nitric Oxide in Carcinogenesis and Clinical Course of

　Cancer 41

Oncogenes and suppressor genes

Functional Analysis of Cancer-related Genes 10

Abnormalities of Known Genes in Human Cancers 28

Isolation of a New Tumor Suppressor Gene Using its Biological Activity

　29

Targeted HST-1 Gene Activation in vivo 32

Genetic and epigenetic alterations

Pathology of Multistep Carcinogenesis 4

Molecular Mechanisms for the Induction of Minisatellite Mutations 7

Gene-disruption Study of Poly (ADP-ribose) Polymerase in Mice 7

STGC Induction in Parp-Knockout ES Cell Tumors 7

Genetic Alterations in Human Cancers 10

Characterization of a Gene Involved in the Repair of Oxidative DNA

　Damage to 8-hydroxyguanine 11

Molecular Epidemiology for Cancer Susceptibility 11

Cloning and Genome Structure of Leukemia-associated Genes 18

Functional Analysis of Leukemia-associated Gene Products 18

Genome Analysis and Genetic Alterations in Human Cancers 19

Analysis of Gene Amplification in Cancer 26

Abnormalities of Known Genes in Human Cancers 28

Abnormalities in Anonymous Regions of the Genome 28

CpG Islands Specifically Methylated in Human Tumors 29

Epigenetic Alterations in Cancer 31

Immunology

Anti-Tumor Immunity of NK-Like T Cells 12

The Identification of the Precursor of Mouse NK1.1⁺ Cytotoxic T Cells

　34

Tumor biology, invasion and metastasis

Molecular and Cellular Mechanisms of Cancer Invasion and Metastasis 4

Tumor-regressing Factor: a Novel Factor Related to but Different from

　Complement Component C3 9

Identification of a Metastasis Suppressor Gene and Construction of a

　Model for the Pleural Metastasis of Lung Cancer 11

Regulation of Apoptosis Signaling 14

The Role of Mitochondria in Cell Suicide System 15

Expression Cloning and Functional Characterization of a cDNA for

　Human Ganglioside GM3 Synthase 23

Functions of an Extracellular Matrix Glycoprotein, Tenascin-C (TN-C),

　in Hematopoietic Microenvironments 23

Cytotoxic Factor Present in Cabbage Butterfly 25

Cloning and Characterization of Human Wnt Receptors 27

Cloning and Characterization of a Novel Transcriptional Factor

　from Endothelial Cells 27

Diagnosis and prognostic factors

Pathology of Multistep Carcinogenesis 4

Molecular Diagnosis of Biological Aggressiveness of Human Cancers 5

Clinicopathological Studies 5

Ectopic Hormone/Cytokine Syndromes 16

Familial Cancer Syndromes: Genetic Testing and Clinical Approaches 16

The Expression of Thioredoxin in Patients with Gastric Cancer 34

Establishment of a New Histopathological Classification for Invasive

　Ductal Carcinoma of the Breast 36

Clinicopathological Study of Atypical Adenomatous Hyperplasia (AAH)

　as a Precancerous Lesion of Lung Adenocarcinoma 36

Application of Histopatholgical Factors to Limited Surgery for Early

　Stage Lung Adenocarcinoma 37

Clinicopathogical Studies of Various Cancer 37

Analysis of Precancerous Lesions 40

Analysis of Lung Cancer Patients with Extreme Clinicopathological

　Features 40

Diagnosing Depression in Cancer Patients 42

Treatment

Anti-angiogenic Activity of Diaminotriazines 9

Anti-Tumor Immunity of NK-Like T Cells 12

Biological and Biochemical Pharmacology 13

Drug Resistance 13

Combination Therapy 13

Induction of Glutathione Synthesis-related Proteins 13

Molecular Therapeutics in Cancer 16

Development of Gene Therapy for Cancer 27

Controlled Release of Plasmid DNAin vivo 33

Antisense Strategy against Human Testicular Tumor 33

The Identification of the Precursor of Mouse NK1.1⁺ Cytotoxic T Cells

　34

A New Method for Treating Small Lung Cancer 40

Construction of a New Strategy of Gene Therapy 41

Symptom Management 43

Psychosocial and Behavioral Factors in the Development of Cancer 43

Epidemiology

Molecular Epidemiology for Cancer Susceptibility 11

Epidemiological Studies 20

Etiological Roles of Foods and Nutrients in Cancer 38

Environmental and Genetic Interaction in the Etiology of Human Cancer

　39

An Epidemiological Evaluation of Cancer Prevention Methods 39

Epidemiological and Biostastical Support for Basic and Clinical

　Research 39

Psychiatric Epidemiology in Cancer Patients 42

Cancer information and biometry

Collection and Analysis of Cancer Databases 20

JCOG Data Center 21

Research and Develoment of Clinical Support Systems 21

WHO Collaborating Centre for Reference on Smoking and Health 21

Others

Analysis of Three-dimensional (3D) Structure of Biological Molecules

　by MO Calculation 15