header

List of Papers Published in 1999

1. Pathology Division

1. Tsuda H,Takarabe T,Fukutomi T,Hirohashi S.der(16)t(1;16)/der(1;16)in breast cancer detected by fluorescence in situ hybridization is an indicator of better patient prognosis.Genes Chromosom Cancer,24:72- 77,1999

2. Tsuda H,Takarabe T,Setsuo H.Correlation of numerical and structural status of chromosome 16 with histological type and grade of non- invasive and invasive breast carcinomas.Int J Cancer (Pred Oncol),84:381- 387,1999

3. Komiya T,Tanigawa Y,Hirohashi S.Cloning and identification of the gene gob- 5, which is expressed in intestinal goblet cells in mice.Biochem Biophys Res Commun, 255:347- 351,1999

4. Komiya T,Tanigawa Y,Hirohashi S.Cloning of the gene gob- 4,which is expressed in intestinal goblet cells in mice.Biochim Biophys Acta,1444:434- 438,1999

5. Kondo Y,Kanai Y,Sakamoto M,Mizokami M,Ueda R,Hirohashi S.Microsatellite instability associated with hepatocarcinogenesis.J Hepatol,31:529- 536,1999

6. Fujii G,Tsuchiya R,Ezoe E,Hirohashi S.Analysis of nuclear localization signals using a green fluorescent protein- fusion protein library.Exp Cell Res,251:299- 306, 1999

7. Kanai Y,Hui A- M,Sun L,Ushijima S,Sakamoto M,Tsuda H,Hirohashi S.DNA hypermethylation at the D17S5 locus and reduced HIC- 1 mRNA expression are asso- ciated with hepatocarcinogenesis.Hepatology,29:703- 709,1999

8. Kanai Y,Ushijima S,Nakanishi Y,Hirohashi S.Reduced mRNA expression of the DNA demethylase,MBD2,in human colorectal and stomach cancers.Biochem Biophys Res Commun,264:962- 966,1999

9. Yasui N,Sakamoto M,Ochiai A,Ino Y,Akimoto S,Orikasa A,Kitajima M,Hirohashi S.Tumor growth and metastasis of human colorectal cancer cell lines in SCID mice resemble clinical metastatic behaviors.Invasion Metastasis,17:259- 269,1997

10. Shimoyama Y,Takeda H,Yoshihara S,Kitajima M,Hirohashi S.Biochemical charac- terization and functional analysis of two type II classic cadherins,cadherin- 6 and - 14,and comparison whith E- cadherin.J Biol Chem,274:11987- 11994,1999

11. Ochiai A,Kanai Y,Hirohashi S.Multiple mechanisms for inactivation of E- cadherin cell adhesion system in cancer.In:Birchmeier W,Birchmeier C (eds),Epithelial Mor- phogenesis in Development and Disease.Amsterdam,Harwood Academic Publishers gmbh,pp 427- 444,1999

12. Saito A,Kanai Y,Maesawa C,Ochiai A,Torii A,Hirohashi S.Disruption on E- cadherin- mediated cell adhesion systems in gastric cancers in young patients.Jpn J Cancer Res,90:993- 999,1999

13. Kondo Y,Kanai Y,Sakamoto M,Genda T,Mizokami M,Ryuzo U,Hirohashi S.b - Catenin accumulation and mutation of exon 3 of the b- catenin gene in hepatocellular carcinoma.Jpn J Cancer Res,90:1301- 1309,1999

14. Harabayashi T,Kanai Y,Yamada T,Sakamoto M,Ochiai A,Kakizoe T,Koyanagi T, Hirohashi S.Reduction of integrin b 4 and enhanced migration on laminin in associa- tion with intraepithelial spreading of urinary bladder carcinomas.J Urol,161:1364- 1371,1999

15. Genda T,Sakamoto M,Ichida T,Asakura H,Kojiro M,Narumiya S,Hirohashi S.Cell motility mediated by Rho and Rho- associated protein kinase plays a critical role in intrahepatic metastasis of human hepatocellular carcinoma.Hapatology,30:1027- 1036,1999

16. Sato H,Hasegawa T,Abe Y,Sakai H,Hirohashi S.Expression of E- cadherin in bone and soft tissue sarcomas:a possible role in epithelial differentiation.Hum Pathol, 30:1344- 1349,1999

17. Nakanishi Y,Ochiai A,Yamauchi Y,Moriya Y,Yoshimura K,Hirohashi S.Clinical implications of lymph node micrometastases in patients with colorectal cancers.On- cology,57:276- 280,1999

18. Ono Y,Nakanishi Y,Ino Y,Niki T,Yamada T,Yoshimura K,Saikawa M,Nakajima T, Hirohashi S.Clinicopathologic significance of laminin- 5 g 2 chain expression in squa- mous cell carcinoma of the tongue:immunohistochemical analysis of 67 lesions.Can- cer,85:2315- 2321,1999

19. Tsuda H,Akiyama F,Kurosumi M,Sakamoto G,Watanabe T.The efficacy and limita- tions of repeated slide conferences for improving interobserver agreement when judg- ing nuclear atypia of breast cancer.Jpn J Clin Oncol,29:68- 73,1999

20. Osada T,Sakamoto M,Nagawa H,Yamamoto J,Matsuno Y,Iwamatsu A,Muto T, Hirohashi S.Acquisition of glutamine synthetase expression in human hepatocarcinogenesis.Cancer,85:819- 831,1999

21. Hasegawa T,Shimoda T,Yokoyama R,Beppu Y,Hirohashi S,Maeda S.Intracortical osteoblastic osteosarcoma with oncogenic rickets.Skeletal Radiol,28:41- 45,1999

22. Nakanishi Y,Ochiai A,Shimoda T,Yamaguchi H,Tachimori Y,Kato H,Watanabe H, Hirohashi S.Heterotopic sebaceous glands in the esophagus:histopathological and immunohistochemical study of a resected esophagus.Pathol Int,49:364- 368,1999

23. Kurisu Y,Shimoda T,Ochiai A,Nakanishi Y,Hirata I,Katsu K,Histologic and immu- nohistochemical analysis of early submucosal invasive carcinoma of the colon and rectum.Pathol Int,49:608- 616,1999

24. Mita T,Nakanishi Y,Ochiai A,Shimoda T,Kato H,Yamaguchi H,Toda G.Paraneoplastic vasculitis associated with esophageal carcinoma.Pathol Int,49:643- 647,1999

25. Yamada Y,Itano N,Narimatsu H,Kudo T,Hirohashi S,Ochiai A,Niimi A,Ueda M, Kimata K.Receptor for Hyaluronan- mediated motility and CD44 expressions in colon cancer assessed by quantitative analysis using real- time reverse transcriptase- poly- merase chain reaction.Jpn J Cancer Res,90:987- 992,1999

26. Yamazaki N,Yamamoto A,Wada T,Ishikawa M,Moriya Y,Nakanishi Y.A case of metastatic extramammary Paget Ġs disease that responded to combination chemo- therapy.J Dermatol,26:311- 316,1999

27. Shimada K,Yamamoto J,Kosuge T,Yamasaki S,Sakamoto M.Adenocarcinoma con- fined to a cholesterol polyp of the gallbladder.Am J Gastroenterol,94:2568- 2569, 1999

28. Takayasu K,Yoshie K,Muramatsu Y,Iwata R,Nakanishi Y,Sakamoto M,Fukuda H, Satake M,Moriyama N,Makino Y.Haemodynamic changes in non- alcoholic (viral) liver cirrhosis studied by computed tomography (CT)arterial portography and CT arteriography.J Gastroenterol Hepatol,14:908- 914,1999

29. Masui F,Matsuno Y,Yokoyama R,Nakanishi Y,Hasegawa T,Kanai Y,Beppu Y, Hirohashi S,Fujii K,Shimoda T.Synovial sarcoma,histologically mimicking primitive neuroectodermal tumor/Ewing's sarcoma at distant sites.Jpn J Clin Oncol,29:438- 441,1999

30. Tsuda H,Takarabe T,Hasegawa T,Murata T,Hirohashi S.Myoepithelial differentia- tion in high- grade invasive ductal carcinomas with large central acellular zones.Hum Pathol,30:1134- 1139,1999

31. Kanamoto A,Kato H,Tachimori Y,Watanabe H,Nakanishi Y,Kondo H,Yamaguchi H, Gotoda T,Muro K,Matsumura Y.No prognostic significance of p53 expression in esophageal squamous cell carcinoma.J Surg Oncol,72:94- 98,1999

32. Okano K,Yamamoto J,Moriya Y,Akasu T,Kosuge T,Sakamoto M,Hirohashi S. Macroscopic intrabiliary growth of liver metastases from colorectal cancer.Surgery, 126:829- 834,1999

33. Tsuda H,Akiyama F,Kurosumi M,Sakamoto G,Watanabe T.Monitoring of interobserver agreement in nuclear atypia scoring of node- negative breast carcino- mas judged at individual collaborating hospitals in the national surgical adjuvant study of breast cancer (NSAS- BC)protocol.Jpn J Clin Oncl,29:413- 420,1999

34. Nakata M,Matsuno Y,Katsumata N,Takenaka T,Kobayashi Y,Narabayashi M,Kagami Y,Ikeda H,Kaneko A,Tobinai K.Histology according to the revised European- Ameri- can lymphoma classification significantly predicts the prognosis of ocular adnexal lymphoma.Leuk Lymphoma,32:533- 543,1999

35. Hokamura N,Kato H,Watanabe H,Tachimori Y,Shimoda T,Nakanishi Y.Fulminant nonocclusive mesenteric ischemia developing just after esophagectomy. Hepatogastroenterology,46:2865- 2867,1999

36. Tanaka M,Shibui S,Nomura K,Yukihiro N.Pineal ganglioneuroblastoma in an adult. J Neurooncol,44:169- 173,1999

2. Biochemistry Division

37. Murata M,Shiraishi T,Fukutome K,Watanabe M,Nagao M,Kubota Y,Ito H,Kawamura J,Yatani R.Cytochrome P4501A1 and glutathione S- transferase M1 genotypes as risk factors for prostate cancer in Japan.Jpn J Clin Oncol,28:657- 660,1998

38. Ishiguro Y,Ochiai M,Sugimura T,Nagao M,Nakagama H.Strain differences of rats in the susceptibility to aberrant crypt foci formation by 2- amino- 1- methyl- 6- phenylimidazo[ 4,5b] pyridine:no implication of Apc and Pla2g2a genetic polymorphisms in differential susceptibility.Carcinogenesis,20:1063- 1068,1999

39. Ochiai M,Nakagama H,Turesky RJ,Sugimura T,Nagao M.A new modification of the 32 P- post- labeling method to recover IQ- DNA adducts as mononucleotides.Mutagen- esis,14:239- 242,1999

40. Nakagama H,Souda K,Ochiai M,Ishiguro Y,Sugimura T,Nagao M.Genetic analysis of the susceptibility in rats to aberrant crypt foci formation by 2- amino- 1- methyl- 6- phenylimidazo [ 4,5- b] pyridine,PhIP.Cancer Lett,143:205- 209,1999

41. Katahira M,Fukuda H,Kawasumi H,Sugimura T,Nakagama H,Nagao M.Intramo- lecular quadruplex formation of the G- rich strand of the mouse hypervariable minisatellite Pc- 1.Biochem Biophys Res Commun,264:327- 333,1999

42. Chun Y- S,Park J- W,Kim M- S,Shima H,Nagao M,Lee S- H,Park S- W,Chung M- H. Role of the 78- kDa glucose- regulated protein as an activity modulator of protein phosphatase1 g 2.Biochem Biophys Res Commun,259:300- 304,1999

43. Ariumi Y,Masutani M,Copeland TD,Mimori T,Sugimura T,Shimotohno K,Ueda K, Hatanaka M,Noda M.Suppression of the poly(ADP- ribose)polymerase activity by DNA- dependent protein kinase in vitro.Oncogene,18:4616- 4625,1999

44. Masutani M,Nozaki T,Nishiyama E,Shimokawa T,Tachi Y,Suzuki H,Nakagama H, Wakabayashi K,Sugimura T.Function of poly(ADP- ribose)polymerase in response to DNA damage:gene- disruption study in mice.Mol Cell Biochem,193:149- 152,1999

45. Masutani M,Suzuki H,Kamada N,Watanabe M,Ueda O,Nozaki T,Jishage K, Watanabe T,Sugimoto T,Nakagama H,Ochiya T,Sugimura T.Poly(ADP- ribose)poly- merase gene disruption conferred mice resistant to streptozotocin- induced diabetes. Proc Natl Acad Sci USA,96:2301- 2304,1999

46. Nozaki T,Masutani M,Watanabe M,Ochiya T,Suzuki H,Nakagama H,Sugimura T. Induction of syncytiotrophoblastic giant cells (STGCs)with extensive hemorrhage in teratocarcinoma derived from Parp -1- mouse embryonic stem cells.Tumor Biol,19:78, 1998

47. Nozaki T,Masutani M,Watanabe M,Ochiya T,Hasegawa F,Nakagama H,Suzuki H, Sugimura T.Syncytiotrophoblastic giant cells in teratocarcinoma- like tumors derived from Parp- disrupted mouse embryonic stem cells.Proc Natl Acad Sci USA.,96:13345- 13350,1999

48. Shimokawa T,Matsutani M,Nagasawa S,Nozaki T,Ikota N,Aoki Y,Nakagama H, Sugimura T.Isolation and cloning of rat poly(ADP- ribose)glycohydrolase:presence of a potential nuclear export signal conserved in mammalian orthologs.J Biochem, 126:748- 755,1999

49. Shimokawa T,Masutani M,Ishiguro Y,Araki S,Aoki Y,Nakagama H,Sugimura T. Linkage mapping of the rat poly(ADP- ribose)glycohydrolase (Parg)gene to chromo- some 16.Exp Anim,48:217- 218,1999

50. Shimokawa T,Masutani M,Nozaki T,Nakagama H,Araki S,Aoki Y,Sugimura T.The human poly(ADP- ribose)glycohydrolase maps to chromosome 10q11.23- 21.1 by fluo- rescence in situ hybridization.Hum Cell,11:243- 246,1998

3. Experimental Pathology and Chemotherapy Division

51. Park CB,Kim DJ,Uehara N,Takasuka N,Baba- Toriyama H,Tsuda H.Heterozygous p53 - deficient mice are not susceptible to 2- amino- 3,8- dimethylimidazo[ 4,5- f] quinoxaline (MeIQx)carcinogenicity.Cancer Lett,139:177- 182,1999

52. Ushida Y,Sekine K,Kuhara T,Takasuka N,Iigo M,Maeda M,Tsuda H.Possible chemopreventive effects of bovine lactoferrin on esophagus and lung carcinogenesis in the rat.Jpn J Cancer Res,90:262- 267,1999

53. Kensler TW,Tsuda H,Wogan GN.United States- Japan workshop on new rodent models for the analysis and prevention of carcinogenesis.Cancer Epidemiol Biomarkers Prev, 8:1033- 1037,1999

54. Ushida Y,Sekine K,Kuhara T,Takasuka N,Iigo M,Tsuda H.Inhibitory effects of bovine lactoferrin on intestinal polyposis in the Apc Min mouse.Cancer Lett,134:141- 145,1998

55. Tanaka K,Ikeda M,Nozaki A,Kato N,Tsuda H,Saito S,Sekihara H.Lactoferrin inhibits hepatitis C virus viremia in patients with chronic hepatitis C:a pilot study. Jpn J Cancer Res,90:367- 371,1999

56. Tsuda H,Park CB,Takasuka N,Baba- Toriyama H,Sekine K,Moore MA,Nomura E, Taniguchi H.Influence of ethyl 3- (4'- geranyloxy- 3'- methoxyphenyl)- 2- propionate (EGMP)on early stage colon carcinogenesis in rats treated with azoxymethane (AOM) ferulic acid.Anticancer Res,19:3779- 3782,1999

57. Tanaka T,Kawabata K,Kakumoto M,Makita H,Ushida J,Honjo S,Hara A,Tsuda H, Mori H.Modifying effects of a flavonoid morin on azoxymethane- induced large bowel tumorigenesis in rats.Carcinogenesis,20:1477- 1484,1999

58. Kawabata K,Tanaka T,Honjo S,Kakumoto M,Hara A,Makita H,Tatematsu N,Ushida J,Tsuda H,Mori H.Chemopreventive effect of dietary flavonoid morin on chemically induced rat tongue carcinogenesis.Int J Cancer,83:381- 386,1999

59. Kim DJ,Park CB,Lee JS,Tsuda H,Furihata C.Enhanced quinone reductase (QR) activity correlates with promotion potential of diethyl maleate (DEM)in rat forestom- ach and glandular stomach carcinogenesis initiated with N- methyl- N'- nitrosoguanidine (MNNG).Cancer Lett,137:193- 200,1999

60. Moore MA,Kunimoto T,Park CB,Takasuka N,Tsuda H.Cross- country comparisons of colon and rectal cancer mortality suggest the existence of differences in risk factors in eastern and western Europe.Eur J Cancer Prev,8:67- 71,1999

61. Moore MA,Kunimoto T,Park CB,Tsuda H.Cross- country comparisons suggest shared risk factors for carcinomas,including male lung adenocarcinoma and colon cancer development.Lung Cancer,24:149- 155,1999

62. Moore MA,Kunimoto T,Tsuda H.Cancer associations at the country level and shared risk factors - a fuzzy concept?Eur J Cancer Prev,8:63- 65,1999

63. Moore MA,Tsuda H.Factors influencing library penetration of cancer research- asso- ciated journals in Japanese universities and research institutions.Jpn J Cancer Res, 90:361- 364,1999

64. Moore MA,Park CB,Tsuda H.European registry comparisons provide evidence of shared risk factors for renal,colon and gallbladder cancer development.Eur J Cancer Prev,8:137- 146,1999

65. Moore MA,Kunimoto T,Tsuda H.Country comparisons provide evidence of links between specific circulatory disease and gastric,rectal,prostate and breast cancers. Eur J Cancer Prev,8:151- 157,1999

66. Moore MA,Tsuda H.Cancer screening:an educational challenge?Eur J Cancer Prev, 8:7- 16,1999

67. Tsuda H,Sekine K,Uehara N,Takasuka N,Moore MA,Konno Y,Nakashita K,Degawa M.Heterocyclic amine mixture carcinogenesis and its enhancement by caffeine in F344 rats.Cancer Lett,143:229- 234,1999

68. Ogawa K,Tsuda H,Shirai T,Ogiso T,Wakabayashi K,Dalgard DW,Thorgeirsson UP, Thorgeirsson SS,Adamson RH,Sugimura T.Lack of carcinogenicity of 2- amino- 3,8- dimethylimidazo[ 4,5- f] quinoxaline (MelQx)in cynomolgus monkeys.Jpn J Cancer Res,90:622- 628,1999

69. Iigo M,Kuhara T,Ushida Y,Sekine K,Moore MA,Tsuda H.Inhibitory effects of bovine lactoferrin on colon carcinoma 26 lung metastasis in mice.Clin Exp Metastasis,17:35- 40,1999

4. Biology Division

70. Eguchi M,Eguchi- Ishimae M,Tojo A,Morishita K,Suzuki K,Sato Y,Kudoh S,Tanaka K,Setoyama M,Nagamura F,Asano S,Kamada N.Fusion of ETV6 to neurotrophin- 3 receptor TRKC in acute myeloid leukemia with t(12;15)(p13;q25).Blood,93:1355- 1363,1999

71. Kohno T,Takakura S,Yamada T,Okamoto A,Tanaka T,Yokota J.Alterations of the PPP1R3 gene in human cancer.Cancer Res,59:4170- 4174,1999

72. Kohno T,Yokota J.How many tumor suppressor genes are involved in human lung carcinogenesis?Carcinogenesis,20:1403- 1410,1999

73. Suzukawa K,Kodera T,Shimizu S,Nagasawa T,Asou H,Kamada N,Taniwaki M, Yokota J,Morishita K.Activation of EVI1 transcripts with chromosomal translocation joining the TCRVb locus and the EVI1 gene in human acute undifferentiated leuke- mia cell line (Kasumi- 3)with a complex translocation of der(3)t(3;7;8).Leukemia, 13:1359- 1366,1999

74. Fujita T,Kiyama M,Tomizawa Y,Kohno T,Yokota J.Comprehensive analysis of p53 gene mutation characteristics in lung carcinoma with special reference to histological subtypes.Int J Oncol,15:927- 934,1999

75. Koike M,Takeuchi S,Park S,Hatta Y,Yokota J,Tsuruoka N,Koeffler HP.Ovarian cancer:loss of heterozygosity frequently occurs in the ATM gene,but structural alter- ations do not occur in this gene.Oncology,56:160- 163,1999

76. Tani M,Shimizu K,Kawahara C,Kohno T,Ishimoto O,Ikawa S,Yokota J.Mutation and expression of the p51 gene in human lung cancer.Neoplasia,1:71- 79,1999

77. Manda R,Kohno T,Matsuno Y,Takenoshita S,Kuwano H,Yokota J.Identification of genes (SPON2 and C20orf2)differentially expressed between cancerous and noncan- cerous lung cells by mRNA differential display.Genomics,61:5- 14,1999

78. Shimizu K,Tani M,Watanabe H,Nagamachi Y,Niinaka Y,Shiroishi T,Ohwada S, RAz A,Yokota J.The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein.Febs Lett,456:295- 300,1999

79. Otsuki M,Fukami K,Kohno T,Yokota J,Takenawa T.Identification and character- ization of a new phospholipase C- like protein,PCL- L2.Biochem Biophys Res Commun, 266:97- 103,1999

80. Kodera T,Kohno T,Takakura S,Morishita K,Hamaguchi H,Hayashi Y,Sasaki T, Yokota J.Microsatellite instability in lymphoid leukemia and lymphoma cell lines but not in myeloid leukemia cell lines.Gene Chromosom Cancer,26:267- 269,1999

81. Adams PD,Li X,Sellers WR,Baker KB,Leng X,Harper JW,Taya Y,Kaelin WGJ. Retinoblastoma protein contains a C- terminal motif that targets it for phosphoryla- tion by cyclin- cdk complexes.Mol Cell Biol,19:1068- 1080,1999

82. Araki R,Fukumura R,Fujimori A,Taya Y,Shiloh Y,Kurimasa A,Burma S,Li GC, Chen DJ,Sato K,Hoki Y,Tatsumi K,Abe M.Enhanced phosphorylation of p53 serine 18 following DNA damage in DNA- dependent protein kinase catalytic subunit- defi- cient cells.Cancer Res,59:3543- 3546,1999

83. Brugarolas J,Moberg K,Boyd SD,Taya Y,Jacks T,Lees JA.Inhibition of cyclin- dependent kinase 2 by p21 is necessary for retinoblastoma protein- mediated G1 ar- rest after g- irradiation.Proc Natl Acad Sci USA,96:1002- 1007,1999

84. Cuddihy AR,Li S,Tam NWN,Wong AH- T,Taya Y,Abraham N,Bell JC,Koromilas AE. Double- stranded- RNA- activated protein kinase PKR enhances transcriptional activa- tion by tumor suppressor p53.Mol Cell Biol,19:2475- 2484,1999

85. Nakagawa K,Taya Y,Tamai K,Yamaizumi M.Requirement of ATM in phosphoryla- tion of the human p53 protein at serine 15 following DNA double- strand breaks.Mol Cell Biol,19:2828- 2834,1999

86. Sarkaria JN,Busby EC,Tibbetts RS,Roos P,Taya Y,Karnitz LM,Abraham RT.Inhi- bition of ATM and ATR kinase activities by the radiosensitizing agent,caffeine.Cancer Res,59:4375- 4382,1999

87. Shieh S- Y,Taya Y,Prives C.DNA damage- inducible phosphorylation of p53 at N- terminal sites including a novel site,Ser20,requires tetramerization.EMBO J,18:1815- 1823,1999

88. Tibbetts RS,Brumbaugh KM,Williams JM,Sarkaria JN,Cliby WA,Shieh S- Y,Taya Y, Prives C,Abraham RT.A role for ATR in the DNA damage- induced phosphorylation of p53.Genes Dev,13:152- 157,1999

89. Nagata Y,Anan T,Yoshida T,Mizukami T,Taya Y,Fujiwara T,Kato H,Saya H,Nakao M.The stabilization mechanism of mutant- type p53 by impaired ubiquitination:the loss of wild- type p53 function and the hsp90 association.Oncogene,18:6037- 6049, 1999

90. Burma S,Kurimasa A,Xie G,Taya Y,Araki R,Abe M,Crissman HA,Ouyang H,Li GC, Chen DJ.DNA- dependent protein kinase- independent activation of p53 in response to DNA damage.J Biol Chem,274:17139- 17143,1999

91. Watanabe Y,Watanabe T,Kitagawa M,Taya Y,Nakayama K- i,Motoyama N.pRb phosphorylation is regulated differentially by cyclin- dependent kinase (Cdk)2 and Cdk4 in retinoic acid- induced neuronal differentiation of P19 cells.Brain Res,842:342- 350,1999

92. Keller D,Zeng X,Li X,Kapoor M,Iordanov MS,Taya Y,Lozano G,Magun B,Lu H.The p38MAPK inhibitor SB203580 alleviates ultraviolet- induced phosphorylation at serine 389 but not serine 15 and activation of p53.Biochem Biophys Res Commun,261:464- 471,1999

93. Duckett DR,Bronstein SM,Taya Y,Modrich P.hMutSa- and hMutLa- dependent phos- phorylation of p53 in response to DNA methylator damage .PNAS,96:12384- 12388, 1999

94. Sugimoto M,Nakamura T,Ohtani N,Hampson L,Hampson IN,Shimamoto A,Furuichi Y,Okumura K,Niwa S,Taya Y,Hara E.Regulation of CDK4 activity by a novel CDK4- binding protein,p34SEI- 1.Genes Dev,13:3027- 3033,1999

95. Sumitomo K,Shimizu E,Shinohara A,Yokota J,Sone S.Activation of RB tumor suppressor protein and growth suppression of small cell lung carcinoma cells by reintroduction of p16INK4A gene.Int J Oncol,14:1075- 1080,1999

96. Kazama H,Kodera T,Shimizu S,Mizoguchi H,Morishita K.Ecotropic viral integration site- 1 is activated during,and is sufficient for,neuroectodermal P19 cell differentia- tion.Cell Growth Differ,10:565- 573,1999

97. Tomizawa Y,Adachi J- i,Kohno T,Hamada K,Saito R,Noguchi M,Matsuno Y,Hirohashi S,Yamaguchi N,Yokota J.Prognostic significance of allelic imbalances on chromo- some 9p in stage I non- small cell lung carcinoma.Clin Cancer Res,5:1139- 1146, 1999

98. Tomizawa Y,Kohno T,Fujita T,Kiyama M,Saito R,Noguchi M,Matsuno Y,Hirohashi S,Yamaguchi N,Nakajima T,Yokota J.Correlation between the status of the p53 gene and survival in patients with stage I non- small cell lung carcinoma.Oncogene, 18:1007- 1014,1999

99. Chida M,Yokoi T,Fukui T,Kinoshita M,Yokota J,Kamataki T.Detection of three genetic polymorphisms in the 5'- flanking region and intron 1 of human CYP1A2 in the Japanese population.Jpn J Cancer Res ,90:899- 902,1999

100. Miyamoto M,Umetsu Y,Dosaka- Akita H,Sawamura Y,Yokota J,Kunitoh H,Nemoto N,Sato K,Ariyoshi N,Kamataki T.CYP2A6 gene deletion reduces susceptibility to lung cancer.Biochem Biophys Res Commun,261:658- 660,1999

101. Sugimura H,Kohno T,Wakai K,Nagura K,Genka K,Igarashi H,Morris BJ,Baba S, Ohno Y,Gao C,Li Z,Wang J,Takezaki T,Tajima K,Varga T,Sawaguchi T,Lum JK, Martinson JJ,Tsugane S,Iwamasa T,Shinmura K,Yokota J.hOGG1 Ser326Cys polymorphism and lung cancer susceptibility.Cancer Epidemiol Biomarkers Prev, 8:669- 674,1999

102. Chida M,Yokoi T,Kosaka Y,Chiba K,Nakamura H,Ishizaki T,Yokota J,Kinoshita M, Sato K,Inaba M,Aoki Y,Gonzalez FJ,Kamataki T.Genetic polymorphism of CYP2D6 in the Japanese population.Pharmacogenetics,9:601- 605,1999

103. Shinmura K,Kohno T,Takahashi M,Sasaki A,Ochiai A,Guilford P,Hunter A,Reeve AE,Sugimura H,Yamaguchi N,Yokota J.Familial gastric cancer:clinicopathological characteristics,RER phenotype and germline p53 and E- cadherin mutations.Car- cinogenesis,20:1127- 1131,1999

104. Caldas C,Carneiro F,Lynch HT,Yokota J,Wiesner GL,Powell SM,Lewis FR,Hunts- man DG,Pharoah PD,Jankowski JA,MacLeod P,Vogelsang H,Keller G,Park KG, Richards FM,Maher ER,Gayther SA,Carla O,Grehan N,Wight D,Seruca R,Roviello F,Ponder BA,Jackson CE.Familial gastric cancer:overview and guidelines for man- agement.J Med Genet,36:873- 880,1999

105. Nagamachi Y,Tani M,Shimizu K,Yoshida T,Yokota J.Suicidal gene therapy for pleural metastasis of lung cancer by liposome- mediated transfer of herpes simplex virus thymidine kinase gene.Cancer Gene Ther,6:546- 553,1999

5. Pharmacology Division

106. Wakasugi H,Miyazaki K,Maruoka H,Kato K,Miyata M,Sugimura T,Masaaki T. Regression and prevention of autochthonous tumors induced by 3- methylcholanthrene after injection of a T- cell receptor a/b positive and CD4/CD8 double negative T- cells. Immunol Lett,69:329- 337,1999

107. Shinohara K,Ikarashi Y,Maruoka H,Miyata M,Sugimura T,Terada M,Wakasugi H. Functional and phenotypical characteristics of hepatic NK- like T cells in NK1.1- posi- tive and - negative mouse strains.Eur J Immunol,29:1871- 1878,1999

108. Miyazaki K,Noda N,Terada M,Wakasugi H.Elevated serum levels of thioredoxin in patients with chronic and/or malignant liver diseases.In:Packer L,Yodoi J (eds), Redox Regulation of Cell Signaling and Its Clinical Application.New York,Marcel Dekker,Inc.,pp 235- 250,1999

109. Miyazaki K,Noda N,Okada S,Hagiwara Y,Miyata M,Sakurabayashi I,Yamaguchi N, Sugimura T,Terada M,Wakasugi H.Elevated serum level of thioredoxin in patients with hepatocellular carcinoma.Biotherapy,11:277- 288,1998

110. Fukumoto H,Nishio K,Ohta S,Hanai N,Fukuoka K,Ohe Y,Sugihara K,Kodama T, Saijo N.Effect of a chimeric anti- ganglioside GM2 antibody on ganglioside GM2- ex- pressing human solid tumors in vivo.Int J Cancer,82:759- 764,1999

111. Kurokawa H,Nishio K,Fukumoto H,Tomonari A,Suzuki T,Saijo N.Alteration of caspase- 3 (CPP32/Yama/apopain)in wild- type MCF- 7,breast cancer cells.Oncol Rep, 6:33- 37,1999

112. Naruse I,Heike Y,Hama S,Mori M,Saijo N.High concentrations of recombinant adenovirus expressing p16 gene induces apoptosis in lung cancer cell lines.Antican- cer Res,18:4275- 4282,1998

113. Yokote H,Nishio K,Arioka H,Kurokawa H,Fukuoka K,Fukumoto H,Ishida T,Terada T,Itakura T,Saijo N.The C- terminal domain of p53 catalyzes DNA- renaturation and strand exchange toward annealing between intact ssDNAs and toward eliminating damaged ssDNA from duplex formation through preferential recognition of damaged DNA by a duocarmycin.Mutat Res,409:147- 162,1998

114. Kanzawa F,Nishio K,Fukuoka K,Sunami T,Saijo N.In vitro interactions of a new derivative of spicamycin,KRN5500,and other anticancer drugs using a three- dimen- sional model.Cancer Chemother Pharmacol,43:353- 363,1999

115. Sunami T,Nishio K,Kanzawa F,Fukuoka K,Kudoh S,Yoshikawa J,Saijo N.Combi- nation effects of TAS- 103,a novel dual topoisomerase I and II inhibitor,with other anticancer agents on human small cell lung cancer cells.Cancer Chemother Pharmacol, 43:394- 401,1999

116. Nishio K,Saijo N.Cytoskeletons and antimitotic agents developed in Japan.Antican- cer Drug Des,14:133- 141,1999

117. Nishio K,Fukuoka K,Fukumoto H,Sunami T,Iwamoto Y,Suzuki T,Usuda J,Saijo N. Mitogen- activated protein kinase antisense oligonucleotide inhibits the growth of hu- man lung cancer cells.Int J Oncol,14:461- 469,1999

118. Tanaka T,Uchiumi T,Nomoto M,Kohno K,Kondo T,Nishio K,Saijo N,Kuwano M. Cellular balance of glutathione levels through the expression of g- glutamylcysteine synthetase and glutathione thiol transferase genes in human hepatic cells resistant to a glutathione poison.Biochim Biophys Acta,1427:367- 377,1999

119. Arioka H,Nishio K,Ishida T,Fukumoto H,Fukuoka K,Nomoto T,Kurokawa H,Yokote H,Abe S,Saijo N.Enhancement of cisplatin sensitivity in high mobility group 2 cDNA- transfected human lung cancer cells.Jpn J Cancer Res,90:108- 115,1999

120. Nishio K,Nakamura T,Koh Y,Suzuki T,Fukumoto H,Saijo N.Drug resistance in lung cancer.Curr Opin Oncol,11:109- 115,1999

6. Biophysics Division

121. Sugiyama A,Noguchi K,Kitanaka C,Katou N,Tashiro F,Ono T,Yoshida MC,Kuchino Y.Molecular cloning and chromosomal mapping of mouse intronless myc gene acting as a potent apoptosis inducer.Gene,226:273- 283,1999

122. Noguchi K,Kitanaka C,Yamana H,Kokubu A,Mochizuki T,Kuchino Y.Regulation of c- Myc through phosphorylation at Ser- 62 and Ser- 71 by c- Jun N- terminal kinase.J Biol Chem,274:32580- 32587,1999

123. Mochizuki T,Kitanaka C,Noguchi K,Muramatsu T,Asai A,Kuchino Y.Physical and functional interactions between Pim- 1 kinase and Cdc25A phosphatase.J Biol Chem, 274:18659- 18666,1999

124. Asai A,Qiu J- h,Narita Y,Chi S,Saito N,Shinoura N,Hamada H,Kuchino Y,Kirino T. High level calcineurin activity predisposes neuronal cells to apoptosis.J Biol Chem, 274:34450- 34458,1999

125. Chi S,Kitanaka C,Noguchi K,Mochizuki T,Nagashima Y,Shirouzu M,Fujita H, Yoshida M,Chen W,Asai A,Himeno M,Yokoyama S,Kuchino Y.Oncogenic Ras triggers cell suicide through the activation of a caspase- independent cell death pro- gram in human cancer cells.Oncogene,18:2281- 2290,1999

126. Kitanaka C,Kuchino Y.Caspase- independent programmed cell death with necrotic morphology.Cell Death Differ,6:508- 515,1999

127. Aida M,Kaneko M,Dupuis M.Radiation- induced DNA damage and repair:an ap- proach from ab initio MO method.In:Leszczynski J (ed),Computational Molecular Biology ,Theoretical Computational Chemistry,vol.8.Amsterdam,Elsevier Science B.V.,pp 211- 243,1999

128. Yamataka H,Aida M.An ab initio MO study on the hydrolysis of methyl chloride.J Mol Struct,461- 462:417- 427,1999

129. Yamataka H,Aida M,Dupuis M.One transition state leading to two product states: ab initio molecular dynamics simulations of the reaction of formaldehyde radical an- ion and methyl chloride.Chem Phys Lett,300:583- 587,1999

130. Tsuboi M,Takeuchi Y,Kawashima E,Ishido Y,Aida M.Raman spectrum of [ 5'- 13C] thymidine:vibrations of its 5'- end atomic group.Spectrochimica Acta Part A,55:1887- 1896,1999

131. Pichierri F,Aida M,Gromiha MM,Sarai A.Free- energy maps of base- amino acid interactions for DNA- protein recognition.J Am Chem Soc,121:6152- 6157,1999

132. Horie N,Yamaizumi Z,Kuchino Y,Takai K,Goldman E,Miyazawa T,Nishimura S, Yokoyama S.Modified nucleosides in the first positions of the anticodons of tRNA Leu 4 and tRNA Leu 5 from Escherichia coli.Biochemistry,38:207- 217,1999

7. Growth Factor Division

133. Kurata N,Kuwabara T,Tanii H,Fuse E,Akiyama T,Akinaga S,Kobayashi H, Yamaguchi K,Kobayashi S.Pharmacokinetics and pharmacodynamics of a novel pro- tein kinase inhibitor,UCN- 01.Cancer Chemother Pharmacol,44:12- 18,1999

134. Manabe T,Fukuda K,Pan J,Nagasaki K,Yamaguchi K,Ogawa S.Hypertrophic stimuli augment expression of cMG1/ERF- 1,a putative zinc- finger motif transcription factor, in rat cardiomyocytes.FEBS Lett,463:39- 42,1999

135. Nagasaki K,Maass N,Manabe T,Hanzawa H,Tsukada T,Kikuchi K,Yamaguchi K. Identification of a novel gene,DAM1,amplified at chromosome 1p13.3- 21 region in human breast cancer celll lines.Cancer Lett,140:219- 226,1999

136. Nagasaki K,Manabe T,Hanzawa H,Maass N,Tsukada T,Yamaguchi K.Identification of a novel gene,LDOC1,down- regulated in cancer cell lines.Cancer Lett,140:227- 234,1999

137. Nagasaki K,Sasaki K,Maass N,Tsukada T,Hanzawa H,Yamaguchi K.Staurosporine enhances cAMP- induced expression of neural- specific gene VGF and tyrosine hydroxy- lase.Neurosci Lett,267:177- 180,1999

138. Ohkura N,Hosono T,Maruyama K,Tsukada T,Yamaguchi K.The human NGFI- B gene gives rise to two isoforms with different expression profiles.Biomed Res,20:213- 218,1999

139. Stieber P,Dienemann H,Schalhorn A,Schmitt UM,Reinmiedl J,Hofmann K, Yamaguchi K.Pro- Gastrin- Releasing Peptide (ProGRP)- A useful marker in small cell lung carcinomas.Anticancer Res,19:2673- 2678,1999

140. Hosono T,Tsukada T,Maruyama K,Kishi M,Ohkura N,Sasaki K,Nara- Ashizawa N, Iwanaga T,Yanaihara N,Kameya T,Yamaguchi K.Antisera against human menin applicable to immunoblotting and immunocytochemistry.Biomed Res,20:51- 55,1999

141. Maruyama K,Tsukada T,Hosono T,Ohkura N,Kishi M,Honda M,Nara- Ashizawa N, Nagasaki K,Yamaguchi K.Structure and distribution of rat menin mRNA.Mol Cell Endocrinol,156:25- 33,1999

142. Kishi M,Tsukada T,Shimizu S,Hosono K,Ohkubo T,Kosuge T,Sugano K,Kanbe M, Obara T,Yamaguchi K.A novel splicing mutation (894- 9 G šA)of the MEN1 gene responsible for multiple endocrine neoplasia type 1.Cancer Lett,142:105- 110,1999

143. Miyauchi A,Futami H,Hai N,Yokozawa T,Kuma K,Aoki N,Kosugi S,Sugano K, Yamaguchi K.Two germline missense mutations at codons 804 and 806 of the RET proto- oncogene in the same allele in a patient with multiple endocrine neoplasia type 2B without codon 918 mutation.Jpn J Cancer Res,90:1- 5,1999

8. Radiobiology Division

144. Ichikawa H,Shimizu K,Katsu R,Ohki M.Dual transforming activities of the FUS(TLS)- ERG leukemia fusion protein conferred by two N- terminal domains of FUS(TLS).Mol Cell Biol,19:7639- 7650,1999

145. Gomyo H,Arai Y,Tanigami A,Murakami Y,Hattori M,Hosoda F,Arai K,Aikawa Y, Tsuda H,Hirohashi S,Asakawa S,Shimizu N,Soeda E,Sakaki Y,Ohki M.A 2- Mb sequence- ready contig map and a novel immunoglobulin superfamily gene IGSF4 in the LHO region of chromosome 11q23.2.Genomics,62:139- 146,1999

146. Gaudray P,Carle GF,Gerhard DS,Gessler M,Mannens MM,Athanasiou M,Bliek J, Calender A,Debelenco LV,Devignes M- D,Evans GA,Favier R,Forbes S,Gaudray G, Gawin B,Gordon M,Grimmond S,Grossfeld P,Harris J,Hattori M,Hosoda F,Holger H,James M,Kalla J,Katsanis N,Little P,Mattina T,Negrini M,Ohki M,Lawrence S, O,Parente F,Quincey D,Raynaud S,Reid L,Rethy LA,Ed S,Sellar G,Stilgenbauer S, Talbot C,Taschner P,Thangarajah T,Tunnacliffe A,Turc- Carel C,Heyningen VV, Weber G,Zabel B.Report of the sixth international workshop on human chromosome 11 mapping 1998.Cytogenet Cell Genet,86:167- 186,1999

147. Nishiyama M,Arai Y,Tsunematsu Y,Kobayashi H,Asami K,Yabe M,Kato S- i,Oda M, Eguchi H,Ohki M,Kaneko Y.11p15 translocations involving the NUP98 gene in child- hood therapy- related acute myeloid leukemia/myelodysplastic syndrome.Gene Chromosom Cancer,26:215- 220,1999

148. Narita M,Shimizu K,Hayashi Y,Taki T,Taniwaki M,Hosoda F,Kobayashi H,Nakamura H,Sadamori N,Ohnishi H,Bessho F,Yanagisawa M,Ohki M.Consistent detection of CALM- AF10 chimaeric transcripts in haematological malignancies with t(10;11)(p13;q14)and identification of novel transcripts.Br J Haematol,105:928- 937,1999

149. Kakazu N,Taniwaki M,Horiike S,Nishida K,Tatekawa T,Nagai M,Takahashi T, Akaogi T,Inazawa J,Ohki M,Abe T.Combined spectral karyotyping and DAPI band- ing analysis of chromosome abnormalities in myelodysplastic syndrome.Genes Chromosom Cancer,26:336- 345,1999

150. Tanaka K,Arif M,Asou H,Shimizu K,Ohki M,Kyo T,Dohy H,Kamada N.Detection of translocation 8;21 on interphase cells from acute myelocytic leukemia by fluores- cence in situ hybridization and its clinical application.Cancer Genet Cytogenet,113:29- 35,1999

9. Cancer Information and Epidemiology Division

151. Kaneko S,Yamaguchi N.Epidemiological analysis of site relationships of synchro- nous and metachronous multiple primary cancers in the National Cancer Center, Japan,1962- 1996.Jpn J Clin Oncol,29:96- 105,1999

152. Kunitoh H,Sekine I,Kubota K,Tamura T,Shinkai T,Kodama T,Saijo N,Naruke T, Yamaguchi N.Histologic types of lung carcinoma and related family history of ana- tomic sites and histologic types of cancers.Cancer,86:1182- 1188,1999

153. Kikuchi Y,Inoue T,Ito M,Masuda M,Yoshimura K,Watanabe S.Health conscious- ness of young people in relation to their personality.J Epidemiol,9:121- 131,1999

154. Ono Y,Araki N,Mitani M,Yoshimura K.Help- seeking behavior acress different age and culture groups.In:Ono Y,Janca A,Asai M,SartorOius N (eds),Somatoform Disorders:A Worldwide Perspective.Tokyo,Springer- Verlag,pp 132- 140,1999

155. Ono Y,Satsumi Y,Kim Y,Iwadate T,Moriyama K,Nakane Y,Nakata T,Okagami K, Sakai T,Sato M,Someya T,Takagi S,Ushijima S,Yamauchi K,Yoshimura K.Schizo- phrenia:is it time to replace the term?Psychiatry Clin Neurosci,53:335- 341,1999

156. Ono Y,Yoshimura K,Mizushima H,Manki H,Yagi G,Kanba S,Nathan J,Asai M. Environmental and posssible genetic contributions to character dimensions of per- sonality.Psychol Rep,84:689- 696,1999

157. Yoshimura K,Nakamura K,Maeda F,Saito N,Sakazume H,Ishii R,Araki N,Ono Y. Economic aspects of somatoform disorders in Japan.In:Ono Y,Janca A,Asai M, SartorOius N (eds),Somatoform Disorders:A Worldwide Perspective.Tokyo,Springer- Verlag,pp 263- 268,1999

158. Sobue T,Ajiki W,Tsukuma H,Oshima A,Hanai A,Fujimoto I.Trends of lung cancer incidence by histologic type:a population- based study in Osaka,Japan.Jpn J Can- cer Res,90:6- 15,1999

159. Sobue T,Tsukuma H,Oshima A,Genka K,Tamori H,Nishizawa N,Natsukawa S. Lung cancer incidence rates by histologic type in high- and low- risk areas;a popula- tion- based study in Osaka,Okinawa,and Saku Nagano,Japan.J Epidemiol,9:134- 142,1999

160. Sasaki F,Kido C,Sobue T,Cui Y,Mori T.Cancer mortality in Thorotrast- exposed patients in Japan:Aichi series.Int J Clin Oncol,4:69- 73,1999

161. Kinjo Y,Beral V,Akiba S,Key T,Mizuno S,Appleby P,Yamaguchi N,Watanabe S, Doll R.Possible protective effect of milk,meat and fish for cerebrovascular disease mortality in Japan.J Epidemiol,9:268- 274,1999

162. Yamaguchi N,Abe K.Gastric cancer.In:Heber D,Blackburn GL,Go VLW (eds),Nu- tritional Oncology.San Diego,Academic Press,pp 477- 487,1999

163. Yamamoto J,Shimada K,Kosuge T,Yamasaki S,Sakamoto M,Fukuda H.Factors influencing survival of patients undergoing hepatectomy for colorectal metastases.Br J Surg,86:332- 337,1999

164. Kobayashi T,Tobinai K,Shimoyama M,Mikuni C,Konda S,Kozuru M,Araki K,Sai T, Fukuhara S,Matsumoto M,Aoki I,Deura K,Oyama A,Hotta T,Abe T,Toki H,Nagai M,Fukuda H,Niimi M,Yamaguchi N,Tajima K,Shirakawa S,(JCOG- LSG) motLSGotJCOG.Long- term follow- up results of adult patients with acute lympho- cytic leukemia or lymphoblastic lymphoma treated with short- term,alternating non- cross- resistant chemotherapy:Japan Clinical Oncology Group Study 8702.Jpn J Clin Oncol,29:340- 348,1999

10. Virology and Glycobiology Division

165. Nishida Y,Takamori Y,Ohrui H,Ishizuka I,Matsuda K,Kobayashi K.Synthesis and absolute configuration of a novel aminoglycoglycerolipid,species- specific major immunodeterminant of Mycoplasma fermentans.Tetrahedron Lett,40:2371- 2374,1999

166. Matsuda K,Ma Y,Barghout V,Ito Y,Chatterjee S.Isolation of less polar alkali- labile glycolipids of human brain by high- speed countercurrent chromatography.J Liq Chromatogr Rel Technol,21:103- 110,1998

167. Ito Y,Matsuda K,Ma Y,Qi L.Toroidal coil counter- current chromatography study of the mass transfer rate of proteins in aqueous- aqueous polymer phase system.J Chromatogr A,802:277- 283,1998

168. Matsuda K,Matsuda S,Ito Y.Toroidal coil counter- current chromatography achieve- ment of high resolution by optimizing flow- rate,rotation speed,sample volume and tube length.J Chromatogr A,808:95- 104,1998

169. Honda H,Nakamoto T,Sakai R,Hirai H.p130 Cas ,an assembling molecule of actin filaments,promotes cell movement,cell migration,and cell spreading in fibroblasts. Biochem Biophys Res Commun,262:25- 30,1999

170. Inudoh M,Kato N,Tanaka Y.New monoclonal antibodies against a recombinant sec- ond envelope protein of hepatitis C virus.Microbiol Immunol,42:875- 877,1998

171. Satoh S,Hirota M,Inudoh M,Kato N,Hijikata M,Shimotohno K.Protein processing of hepatitis C virus and investigation of the effects of viral proteins on cell prolifera- tion.In:Schinazi RF,Sommadossi J- P,Thomas HC (eds),Therapies for Viral Hepati- tis.London,International Medical Press,pp 263- 269,1998

172. Tanaka K,Ikeda M,Nozaki A,Kato N,Tsuda H,Saito S,Sekihara H.Lactoferrin inhibits hepatitis C virus viremia in patients with chronic hepatitis C:a pilot study. Jpn J Cancer Res,90:367- 371,1999

11. Cancer Prevention Division

173. Ohe T,Takeuchi N,Watanabe T,Tada A,Nukaya H,Terao Y,Sawanishi H,Hirayama T,Sugimura T,Wakabayashi K.Quantification of two aromatic amine mutagens, PBTA- 1 and PBTA- 2,in the Yodo River system.Environ Health Perspect,107:701- 704,1999

174. Ohe T,Shaughnessy DT,Landi S,Terao Y,Sawanishi H,Nukaya H,Wakabayashi K, DeMarini DM.Mutation spectra in Salmonella TA98,TA100,and TA104 of two phenylbenzotriazole mutagens (PBTA- 1 and PBTA- 2)detected in the Nishitakase River in Kyoto,Japan.Mutation Res,429:189- 198,1999

175. Shiozawa T,Suyama K,Nakano K,Nukaya H,Sawanishi H,Oguri A,Wakabayashi K, Terao Y.Mutagenic activity of 2- phenylbenzotriazole derivatives related to a mutagen, PBTA- 1,in river water.Mutat Res,442:105- 111,1999

176. Hayatsu H,Mimaki S,Ishizaki N,Wakabayshi K,Sugiyama C.Copper phthalocya- nine- chitin,an adsorbent for carcinogen- nucleotide adducts.Collection symposium series:Chemistry of nucleic acid components:11th Symposium,Spindleruv Mlyn, Czech Republic,1999,2:175- 179,1999

177. Watanabe T,Ishida S,Kishiji M,Takahashi Y,Furuta A,Kasai T,Wakabayashi K, Hirayama T.High- performance liquid chromatography- fluorescence determination of dinitropyrenes in soil after column chromatographic clean- up and on- line reduction. J Chromatogr A,839:41- 48,1999

178. Totsuka Y,Ushiyama H,Ishihara J,Sinha R,Goto S,Sugimura T,Wakabayashi K. Quantification of the co- mutagenic b - carbolines,norharman and harman,in ciga- rette smoke condensates and cooked foods.Cancer Lett,143:139- 143,1999

179. Masumura K,Matsui K,Yamada M,Horiguchi M,Ishida K,Watanabe M,Ueda O, Suzuki H,Kanke Y,Tindall KR,Wakabayashi K,Sofuni T,Nohmi T.Mutagenicity of 2- amino- 1- methyl- 6- phenylimidazo [ 4,5- b] pyridine (PhIP)in the new gpt ƒjtransgenic mouse.Cancer Lett,143:241- 244,1999

180. Sugimura T,Wakabayashi K.Carcinogens in foods.In:Shils ME,Olson JA,Shike M, Ross AC (eds),Modern Nutrition in Health and Disease,9th Edition.Baltimore,Will- iams & Wilkins,pp 1255- 1261,1999

181. Watanabe K,Kawamori T,Nakatsugi S,Ohta T,Ohuchida S,Yamamoto H,Maruyama T,Kondo K,Ushikubi F,Narumiya S,Sugimura T,Wakabayashi K.Role of the pros- taglandin E receptor subtype EP 1 in colon carcinogensis.Cancer Res,59:5093- 5096, 1999

182. Onozawa M,Kawamori T,Baba M,Fukuda K,Toda T,Sato H,Ohtani M,Akaza H, Sugimura T,Wakabayashi K.Effects of a soybean isoflavone mixture on carcinogen- esis in prostate and seminal vesicles of F344 rats.Jpn J Cancer Res,90:393- 398, 1999

183. Furukawa F,Nishikawa A,Kasahara K,Lee I- S,Wakabayashi K,Takahashi M,Hirose M.Inhibition by b - carotene of upper respiratory tumorigenesis in hamsters receiving diethylnitrosamine followed by cigarette smoke exposure.Jpn J Cancer Res,90:154- 161,1999

184. Isimura Y,Watanabe H,Kato N,Yanagita T,Wakabayashi K.Hypertriglyceridemia in rats induced by consumption of a food- derived carcinogen,2- amino- 1 methyl- phenylimidazo[ 4,5- b] pyridine (PhIP).Biosci Biotechnol Biochem,63:1634- 1636,1999

185. Yoshimoto M,Tsutsumi M,Iki K,Sasaki Y,Tsujiuchi T,Sugimura T,Wakabayashi K, Konishi Y.Carcinogenicity of heterocyclic amines for the pancreatic duct epithelium in hamsters.Cancer Lett,143:235- 239,1999

186. Tsukamoto T,Kozaki K- i,Nishikawa Y,Yamamoto M,Fukami H,Inoue M,Wakabayashi K,Tatematsu M.Development and distribution of 2- amino- 1- methyl- 6- phenylimidazo[ 4,5- b] pyridine (PhIP)- induced aberrant crypt foci in the rat large intes- tine.Jpn J Cancer Res,90:720- 725,1999

187. Kono T,Watanabe M,Koyama K,Kishimoto T,Fukushima S,Sugimura T,Wakabayashi K.Cytotoxic activity of pierisin,from the cabbage butterfly, Pieris rapae,in various human cancer cell lines.Cancer Lett,137:75- 81,1999

188. Watanabe M,Kono T,Matsushima- Hibiya Y,Kanazawa T,Nishisaka N,Kishimoto T, Koyama K,Sugimura T,Wakabayashi K.Molecular cloning of an apoptosis- inducing protein,pierisin,from cabbage butterfly:possible involvement of ADP- ribosylation in its activity.Proc Natl Acad Sci USA,96:10608- 10613,1999

189. Koyama K,Baba M,Watanabe M,Takahashi H,Ishiyama H,Sugimura T,Wakabayashi K.Cytotoxic agent against human gastric carcinoma cells from a kind of Danaidae and its host plant.Proc Jpn Acad Ser B,75:7- 9,1999

12. Genetics Division

190. Tanooka H.Biological effects of low doses of radiation.In:Baumstark- Khan C,Kozubek S,Horneck G (eds),Fundamentals for the Assessment of Risks from Environmental Radiation.Netherlands,Kluwer Academic Publishers,pp 471- 478,1999

191. Tanooka H,Ootsuyama A,Sasaki H.Homologous recombination between p53 and its pseudogene in a radiation- induced mouse tumor.Cancer Res,58:5649- 5651,1998

192. Mori T,Fukutomi K,Kato Y,Hatakeyama S,Machinami R,Tanooka H,Ishikawa Y, Kumatori T.1998 results of the first series of follow- up studies on Japanese thorotrast patients and their relationships to an autopsy series.Radiat Res,152:S72- S80,1999

193. Ueda T,Sasaki H,Kuwahara Y,Nezu M,Shibuya T,Sakamoto H,Ishii H,Yanagihara K,Mafune K,Makuuchi M,Terada M.Deletion of the carboxyl- terminal exons of K- sam/FGFR2 by short homology- mediated recombination,generating preferential ex- pression of specific messenger RNAs.Cancer Res,59:6080- 6086,1999

194. Ueda T,Sasaki H,Aoyagi K,Narikiyo M,Tsubosa Y,Kuwahara Y,Sakamoto H,Mafune K,Yoshida T,Makuuchi M,Terada M.Novel exsons located more than 200 kb down- stream of the previously described 3'exon of the K- sam gene for generating activated forms of KGF receptor.Biochem Biophys Res Commun,265:739- 745,1999

195. Nezu M,Sasaki H,Kuwahara Y,Ochiya T,Yamada Y,Sakamoto H,Tashiro H,Yamazaki M,Ikeuchi T,Saito Y,Terada M.Identification of a novel promoter and exons of the c- ERBB- 2 gene.Biochem Biophys Res Commun,258:499- 505,1999

196. Sagara N,Toda G,Hirai M,Terada M,Katoh M.Molecular cloning,differential expres- sion,and chromosomal localization of human Frizzled- 1,Frizzled- 2,and Frizzled- 7. Biochem Biophys Res Commun,252:117- 122,1998

197. Kirikoshi H,Sagara N,Koike J,Tanaka K,Sekihara H,Hirai M,Katoh M.Molecular cloning and characterization of human Frizzled- 4 on chromosome 11q14- q21.Biochem Biophys Res Commun,264:955- 961,1999

198. Koike J,Takagi A,Miwa T,Hirai M,Terada M,Katoh M.Molecular cloning of Frizzled- 10,a novel member of the Frizzled gene family.Biochem Biophys Res Commun,262:39- 43,1999

199. Ohnami S,Matsumoto N,Nakano M,Aoki K,Nagasaki K,Sugimura T,Terada M, Yoshida T.Identification of genes showing differential expression in antisense K- ras- transduced pancreatic cancer cells with suppressed tumorigenicity.Cancer Res, 59:5565- 5571,1999

200. Yoshida T.Introducing 'Cancer Genetics Report ' as a new section in JJCO:Dawn of post- sequencing age of human genome project.Jpn J Clin Oncol,29:457- 459,1999

201. Takahashi A,Sasaki H,Kim SJ,Kakizoe T,Miyao N,Sugimura T,Terada M,Tsukamoto T.Identification of receptor genes in renal cell carcinoma associated with angiogen- esis by differential hybridization technique.Biochem Biophys Res Commun,257:855- 859,1999

202. Jones N,Master Z,Jones J,Bouchard D,Gunji Y,Sasaki H,Daly R,Alitalo K,Dumont DJ.Identification of Tek/Tie2 binding partners.J Biol Chem,274:30896- 30905,1999

203. Suzuki K,Kazui T,Yoshida M,Uno T,Kobayashi T,Kimura T,Yoshida T,Sugimura H.Drug- induced apoptosis and p53,BCL- 2 and BAX expression in breast cancer tissues in vivo and in fibroblast cells in vitro.Jpn J Clin Oncol,29:323- 331,1999

204. Yamamoto H,Perez- Piteira J,Yoshida T,Terada M,Itoh F,Imai K,Perucho M.Gastric cancers of the microsatellite mutator phenotype display characteristic genetic and clinical features.Gastroenterology,116:1348- 1357,1999

205. Li X- J,Wang D- Y,Zhu Y,Guo R- J,Wang X- D,Lubomir K,Mukai K,Sasaki H,Yoshida H,Oka T,Machinami R,Shinmura K,Tanaka M,Sugimura H.Mxil mutations in human neurofibrosarcomas.Jpn J Cancer Res,90:740- 746,1999

13. Oncogene Division

206. Kawamura M,Ohnishi H,Guo S- X,Sheng XM,Minegishi M,Hanada R,Horibe K, Hongo T,Kaneko Y,Bessho F,Yanagisawa M,Sekiya T,Hayashi Y.Alterations of the p53,p21,p16,p15 and RAS genes in childhood T- cell acute lymphoblastic leukemia. Leuk Res,23:115- 126,1999

207. Kawakami K,Yasuda J,Kayama T,Doi K,Sekiya T.Structures of primer- template hybrids in arbitrarily primed polymerase chain reaction.Genet Anal,15:5- 8,1999

208. Kuchiki H,Yasuda J,Kayama T,Murakami Y,Sekiya T.Detection of DNA abnormali- ties by arbitrarily primed PCR fingerprinting:amplification of the MDM2 gene in a mediastinum fibrosarcoma.Biochem Biophys Res Commun,258:271- 277,1999

209. Shiraishi M,Sekiguchi A,Chuu YH,Sekiya T.Tight interaction between densely me- thylated DNA fragments and the methyl- CpG binding domain of the rat MeCP2 pro- tein attached to a solid support.Biol Chem,380:1127- 1131,1999

210. Shiraishi M,Sekiguchi A,Chuu YH,Sekiya T.Alteration of mosaic methylation of the repeat unit of the human ribosomal RNA genes in lung cancer.Biol Chem,380:81- 84, 1999

211. Shiraishi M,Chuu YH,Sekiya T.Isolation of DNA fragments associated with methy- lated CpG islands in human adenocarcinomas of the lung using a methylated DNA binding column and denaturing gradient gel electrophoresis.Proc Natl Acad Sci USA, 96:2913- 2918,1999

14. Carcinogenesis Division

212. Ushijima T,Nagao M.A rat model system for predisposition to stomach cancer.In: Hiai H,Hino O (eds),Animal Models of Cancer Predisposition Syndromes.Basel,Karger, pp 120- 130,1999

213. Hirayama Y,Ushijima T,Kuramoto T,Kitano M,Sugimura T,Nagao M.Linkage map- ping of the rat Msh2 DNA mismatch repair gene on chromosome 6.Exp Anim,48:63- 64,1999

214. Hirayama Y,Wakazono K,Yamamoto M,Kitano M,Tatematsu M,Nagao M,Sugimura T,Ushijima T.Rare mutations of p53,Ki- ras,and b - catenin genes and absence of K- sam and c- erbB- 2 amplification in N- methyl- N'- nitro- N- nitrosoguanidine- induced rat stomach cancers.Mol Carcinog,25:42- 47,1999

215. Yoshida Y,Ushijima T,Yamashita S,Imai K,Sugimura T,Nagao M.Development of the arbitrarily primed- representational difference analysis method and chromosomal mapping of isolated high throughput rat genetic markers.Proc Natl Acad Sci USA, 96:610- 615,1999

216. Ushijima T,Nomoto T,Sugimura T,Housman DE,Nagao M.Isolation of 48 genetic markers appropriate for high throughput genotyping of inbred rat strains by B1 re- petitive sequence- representational difference analysis.Mamm Genome,9:1008- 1012, 1998

217. Nagao S,Ushijima T,Kasahara M,Yamaguchi T,Kusaka M,Matsuda J,Nagao M, Takahashi H.Closely linked polymorphic markers for determining the autosomal domi- nant allele (Cy)in rat polycystic kidney disease.Biochem Genet,37:227- 235,1999

218. Suzui M,Ushijima T,Dashwood RH,Yoshimi N,Sugimura T,Mori H,Nagao M.Fre- quent mutations of the rat b - catenin gene in colon cancers induced by methylazoxymethanol acetate plus 1- hydroxyanthraquinone.Mol Carcinog,24:232- 237,1999

219. Chung F- L,Nath RG,Nagao M,Nishikawa A,Zhou G- D,Randerath K.Endogenous formation and significance of 1,N 2 - propanodeoxyguanosine adducts.Mutat Res, 424:71- 81,1999

220. Okochi E,Watanabe N,Shimada Y,Takahashi S,Wakazono K,Shirai T,Sugimura T, Nagao M,Ushijima T.Preferential induction of guanine deletion at 5'- GGGA- 3'in rat mammmary grands by 2- amino- 1- methyl- 6- phenylimidazo[ 4,5- b] pyridine.Carcino- genesis,20:1933- 1938,1999

221. Fujita H,Nagano K,Ochiai M,Ushijima T,Sugimura T,Nagao M,Matsushima T. Difference in target organs in carcinogenesis with a heterocyclic amine,2- amino- 3,4- dimethylimidazo[ 4,5- f] quinoline,in different strains of mice.Jpn Cancer Res,90:1203- 1206,1999

15. Section for Studies on Metastasis

222. Ochiya T,Takahama Y,Nagahara S,Sumita Y,Hisada A,Itoh H,Nagai Y,Terada M. New delivery system for plasmid DNA in vivo using atelocollagen as a carrier material: the Minipellet.Nat Med,5:707- 710,1999

223. Ochiya T,Takahama Y,Baba- Toriyama H,Tsukamoto M,Yasuda Y,Kikuchi H,Terada M.Evaluation of cationic liposome suitable for gene transfer into pregnant animals. Biochem Biophys Res Commun,258:358- 365,1999

224. Ochiya T,Terada M.Antisense approaches to in vitro organ culture.Methods Enzymol, 314:401- 411,1999

225. Konishi H,Ochiya T,Muto T,Sugimura T,Terada M.Toward targeted killing of tu- mor- specific antigen- producing cancer cells by retrovirus displaying a single chain variable fragment antibody.Adv Exp Med Biol,451:405- 410,1998

226. Takahama Y,Ochiya T,Tanooka H,Yamamoto H,Sakamoto H,Nakano H,Terada M. Adenovirus- mediated transfer of HST- 1/FGF- 4 gene protects mice from lethal irra- diation.Oncogene,18:5943- 5947,1999

227. Grako KA,Ochiya T,Barritt D,Nishiyama A,Stallcup WB.PDGF a - receptor is unre- sponsive to PDGF- AA in aortic smooth muscle cells from the NG2 knockout mouse.J Cell Sci,112:905- 915,1999

17. Pathology Division, East

228. Nishimura R,Hasebe T,Tsubono Y,Ono M,Sugitoh M,Arai T,Mukai K.The fibrotic focus in advanced colorectal carcinoma:a hitherto unrecognized histological predic- tor for liver metastasis.Virchows Arch,433:517- 522,1998

229. Koyama T,Hasebe T,Tsuda H,Hirohashi S,Sasaki S,Fukutomi T,Imoto S,Umeda T, Mukai K.Histological factors associated with initial bone metastasis of invasive duc- tal carcinoma of the breast.Jpn J Cancer Res,90:294- 300,1999

230. Jitsuiki Y,Hasebe T,Tsuda H,Imoto S,Tsubono Y,Sasaki S,Mukai K.Opitimizing microvessel counts according to tumor zone in invasive ductal carcinoma of the breast. Mod Pathol,12:492- 498,1999

231. Niho S,Yokose T,Suzuki K,Kodama T,Nishiwaki Y,Mukai K.Monoclonality of atypi- cal adenomatous hyperplasia of the lung.Am J Pathol,154:249- 254,1999

232. Sekine I,Nishiwaki Y,Yokose T,Nagai K,Suzuki K,Kodama T.Young lung cancer patients in Japan:different characteristics between the sexes.Ann Thorac Surg, 67:1451- 1455,1999

233. Suzuki K,Nagai K,Yoshida J,Nishimura M,Takahashi K,Yokose T,Nishiwaki Y. Conventional clinicopathologic prognostic factors in surgically resected nonsmall cell lung carcinoma .Cancer,86:1976- 1984,1999

234. Yokose T,Doy M,Taniguchi T,Shimada T,Kakiki M,Horie T,Matsuzaki Y,Mukai K. Immunohistochemical study of cytochrome P450 2C and 3A in human non- neoplas- tic and neoplastic tissues.Virchows Arch,434:401- 411,1999

235. Sekine I,Kodama T,Hasebe T,Matsumoto T,Nagai K,Nishiwaki Y.Mediastinal germ cell tumor complicated by visceral hemangiomatosis.Int Med,37:1042- 1045,1998

236. Niho S,Yokose T,Nagai K,Nishiwaki Y,Kodama T,Mukai K.A case of synchronous double primary lung cancer with neuroendocrine features.Jpn J Clin Oncol,29:219- 225,1999

237. Kodama K,Yokose T,Takahashi K,Minami H,Nagai K,Matsuno Y,Nishiwaki Y, Ochiai A.Low- grade B- cell lymphoma of mucosa- associated lymphoid tissue in the lung:a report of a case with pleural dissemination.Lung Cancer,24:175- 178,1999

238. Hasebe T,Imoto S,Sasaki S,Tsubono Y,Mukai K.Proliferative activity and tumor angiogenesis is closely correlated to stromal cellularity of fibroadenoma:proposal fi- broadenoma,cellular variant.Pathol Int,49:435- 443,1999

239. Izuishi K,Imoto S,Hasebe T.Signet ring cell carcinoma associated with invasive ductal carcinoma of the breast:a case report.Breast Cancer,6:223- 226,1999

240. Muto M,Ohtsu A,Boku N,Hosokawa K,Fujii T,Hasebe T,Tajiri H,Yoshida S.Minute invasive squamous cell carcinoma of the esophagus associated with head and neck cancer:a case report.Endoscopy,31:S27- S28,1999

241. Muto M,Hasebe T,Muro K,Boku N,Ohtsu A,Fujii T,Ono M,Tajiri H,Mukai K, Yoshida S.Primary squamous cell carcinoma of the stomach:a case report with a review of Japanese and Western literature.Hepatogastroenterology,46:3015- 3018, 1999

242. Fujii K,Kosuge T,Mukai K,Shimada K,Yamamoto J,Yamasaki S,Tajiri H,Ochiai A, Yoshida S.Localized nodular idiopathic retroperitoneal fibrosis:successful treatment with surgical resection.Pancreas,19:213- 215,1999

243. Imoto S,Hasebe T.Initial experience with sentinel node biopsy in breast cancer at the National Cancer Center Hospital East.Jpn J Clin Oncol,29:11- 15,1999

244. Niho S,Yokose T,Nishiwaki Y,Mukai K.Immunohistochemical and clonal analysis of minute pulmonary meningothelial- like nodules.Hum Pathol,30:425- 429,1999

245. Li X- J,Wang D- Y,Zhu Y,Guo R- J,Wang X- D,Lubomir K,Mukai K,Sasaki H,Yoshida H,Oka T,Machinami R,Shinmura K,Tanaka M,Sugimura H.Mxi1 mutations in human neurofibrosarcomas.Jpn J Cancer Res,90:740- 746,1999

246. Imoto S,Kitoh T,Hasebe T.Serum c- erbB- 2 levels in monitoring of operable breast cancer patients.Jpn J Clin Oncol,29:336- 339,1999

247. Kamiya N,Yokose T,Kiyomatsu Y,Fahey MT,Kodama T,Mukai K.Assessment of DNA content in formalin- fixed,paraffin- embedded tissue of lung cancer by laser scan- ning cytometer.Pathol Int,49:695- 701,1999

248. Niho S,Yokose T,Kodama T,Nishiwaki Y,Mukai K.Clonal analysis of adenosquamous carcinoma of the lung.Jpn J Cancer Res,90:1244- 1247,1999

249. Konishi K,Fujii T,Boku N,Kato S,Koba I,Ohtsu A,Tajiri H,Ochiai A,Yoshida S. Clinicopathological differences between colonic and rectal carcinomas:are they based on the same mechanism of carcinogenesis?Gut,45:818- 821,1999

18. Epidemiology and Biostatistics Division

250. Tsugane S,Fahey MT,Sasaki S,Baba S.Alcohol consumption and all- cause and cancer mortality among middle- aged Japanese men:seven- year follow- up of the JPHC study cohort 1.Am J Epidemiol,150:1201- 1207,1999

251. Tsubono Y,Tsugane S,Gey KF.Plasma antioxidant vitamins and carotenoids in five Japanese populations with varied mortality from gastric cancer.Nutr Cancer,34:56- 61,1999

252. Kobayashi M,Sasaki S,Hamada GS,Tsugane S.Serum n- 3 fatty acids,fish con- sumption and cancer mortality in six Japanese populations in Japan and Brazil.Jpn J Cancer Res,90:914- 921,1999

253. Sasaki S,Kobayashi M,Tsugane S.Development of substituted fatty acid food com- position table for the use in nutritional epidemiologic studies for Japanese popula- tions:its methodological backgrounds and the evaluation.J Epidemiol,9:190- 207, 1999

254. Zhang J,Sasaki S,Amano K,Kesteloot H.Fish consumption and mortality from all causes,ischemic heart disease,and stroke:an ecological study.Prev Med,28:520- 529,1999

255. Tsugane S,Fahey MT,Hamada GS,Kabuto M,Miyakawa VY.Helicobacter pylori in- fection and atrophic gastritis in middle- aged Japanese residents of Sao Paulo and Lima.Int J Epidemiol,28:577- 582,1999

256. Sasaki S,Ishikawa T,Yanagibori R,Amano K.Responsiveness to a self- administered diet history questionnaire in a work- site dietary intervention trial for mildly hyperc- holesterolemic Japanese subjects:correlation between change in dietary habits and serum cholesterol levels.J Cardiol,33:327- 338,1999

257. Sasaki H,Oda M,Ohmura M,Akiyama M,Liu CQ,Tsugene S,Terashima Y,Tanaka T.Follow up of women with simple ovarian cysts detected by transvaginal sonography in the Tokyo metropolitan area.Br J Obstet Gynaecol,106:415- 420,1999

258. Liu CQ,Sasaki H,Fahey MT,Sakamoto A,Sato S,Tanaka T.Prognostic value of nuclear morphometry in patients with TNM stage T1 ovarian clear cell adenocarci- noma.Br J Cancer,79:1736- 1741,1999

259. Sekine I,Nagai K,Tsugane S,Yokose T,Kodama T,Nishiwaki Y,Suzuki K,Kuriyama T.Association between smoking and tumor progression in Japanese women with adenocarcinoma of the lung.Jpn J Cancer Res,90:129- 135,1999

19. Investigative Treatment Division

260. Baroni A,Ruocco V,De Paolis P,Cicatiello L,Esumi H,Tufano MA.Ketoconazole inhibits lipopolysaccharide- induced activation of the nitric oxide synthase gene in the murine macrophage cell line J774.Arch Dermatol Res,291:54- 58,1999

261. Iwasaki T,Hori H,Hayashi Y,Nishino T,Tamura K,Oue S,Iizuka T,Ogura T,Esumi H.Characterization of mouse nNOS2,a natural variant of neuronal nitric- oxide syn- thase produced in the central nervous system by selective alternative splicing.J Biol Chem,274:17559- 17566,1999

262. Tatemichi M,Nomura S,Ogura T,Sone H,Nagata H,Esumi H.Mutagenic activation of environmental carcinogens by microsomes of gastric mucosa with intestinal meta- plasia.Cancer Res,59:3893- 3898,1999

263. Otori K,Sugiyama K,Fukushima S,Esumi H.Expression of the cyclin D1 gene in rat colorectal aberrant crypt foci and tumors induced by azoxymethane.Cancer Lett, 140:99- 104,1999

20. Psycho-Oncology Division

264. Uchitomi Y.Psycho- oncology in Japan:history,current problems and future aspect. Jpn J Clin Oncol,29:411- 412,1999

265. Kugaya A,Akechi T,Okamura H,Mikami I,Uchitomi Y.Correlates of depressed mood in ambulatory head and neck cancer patients.Psychooncology,8:494- 499,1999

266. Akechi T,Kugaya A,Okamura H,Nakano T,Okuyama T,Mikami I,Shima Y,Yamawaki S,Uchitomi Y.Suicidal thoughts in cancer patients:clinical experience in psycho- oncology.Psychiatry Clin Neurosci,53:569- 573,1999

267. Nishida A,Zensho H,Hisaoka K,Okamoto Y,Shinno H,Uchitomi Y,Yamawaki S. Molecular mechanisms of alcoholism in the nervous system.Recent Res Dev Neurochem,2:139- 155,1999

268. Mikami I,Akechi T,Kugaya A,Okuyama T,Nakano T,Okamura H,Yamawaki S, Uchitomi Y.Screening for nicotine dependence among smoking- related cancer pa- tients.Jpn J Cancer Res,90:1071- 1075,1999

269. Kugaya A,Akechi T,Nakano T,Okamura H,Shima Y,Uchitomi Y.Successful antide- pressant trearment for five terminally ill cancer patients with major depression,sucidal ideation and a desire for death.Support Care Cancer,7:432- 436,1999

270. Oshima A,Higuchi T,Fujiwara Y,Iida M,Iwanami A,Kanba S,Motohashi N,Uchitomi Y,Yamada K,Yamawaki S.Questionnaire survey on the prescribing practice of Japa- nese psychiatrists for mood disorders.Psychiatry Clin Neurosci,53:S67- S72,1999

271. Higuchi T,Fujiwara Y,Iida M,Iwanami A,Kanba S,Hideaki K,Motohashi N,Oshima A,Shioe Y,Yamada K,Yamawaki S,Yokota N,Sato M.Algorithm for the treatment of mood disorders in Japan.Int J Psychiatry Clin Pract,3:277- 285,1999

272. Nakano T,Kugaya A,Akechi T,Mikami I,Okuyama H,Uchitomi Y.Algorithm for the treatment of major depression in patients with advanced cancer.Psychiatry Clin Neurosci,53:S61- S65,1999

273. .Akechi T,Kugaya A,Okamura H,Yamawaki S,Uchitomi Y.Fatigue and its associated factors in ambulatory cancer patients:a preliminary study.J Pain Symptom Manage, 17:42- 48,1999

21. President Emeritus

274. Sugimura T.A new concept of co- mutagenicity from a phenomenon forgotten for the past two decades.Is it more important than previously expected?Environ Health Perspect,106:A522- A523,1998

275. Sugimura T.Past victories,uncertainty,and reflections on the present and progress in the future.Gastric Cancer,1:5- 7,1998