List of Papers Published in 2000
1. Pathology Division 1. Tokunou M, Niki T, Saitoh Y, Imamura H, Sakamoto M, Hirohashi S. Altered expression of the ERM proteins in lung adenocarcinoma. Lab Invest, 80:1643- 1650, 2000 2. Anami Y, Takeuchi T, Mase K, Yasuda J, Hirohashi S, Perucho M, Noguchi M. Amplotyping of microdissected, methanol-fixed lung carcinoma by arbitrarily primed polymerase chain reaction. Int J Cancer (Pred Oncol), 89:19-25, 2000 3. El- Husseini AE-D, Kwasnicka D, Yamada T, Hirohashi S, Vincent SR. BERP, a novel ring finger protein, binds to a-Actinin-4. Biochem Biophys Res Commun, 267:906-911, 2000 4. Ishii Y, Ochiai A, Yamada T, Akimoto S, Yanagihara K, Kitajima M, Hirohashi S. Integrin a6b4 as a suppressor and a predictive marker for peritoneal dissemination in human gastric cancer. Gastroenterology, 118:497-506, 2000 5. Niki T, Iba S, Tokunou M, Yamada T, Matsuno Y, Hirohashi S. Expression of vascular endothelial growth factors A, B, C, and D and their relationships to lymph node status in lung adenocarcinoma. Clin Cancer Res, 6:2431-2439, 2000 6. Pasqualini R, Koivunen E, Kain R, Lahdenranta J, Sakamoto M, Stryhn A, Ashmun RA, Shapiro LH, Arap W, Ruoslahti E. Aminopeptidase N is a receptor for tumor- homing peptides and a target for inhibiting angiogenesis. Cancer Res, 60:722-727, 2000 7. Tchou JC, Lin X, Freije D, Isaacs WB, Brooks JD, Rashid A, De Marzo AM, Kanai Y, Hirohashi S, Nelson WG. GSTP1 CpG island DNA hypermethylation in hepatocellular carcinomas. Int J Oncol, 16:663- 676, 2000 8. Tsuda H, Takarabe T, Fukutomi T, Hirohashi S. Preferential occurrence of breast carcinomas with loss of chromosome 16q and der(16)t(1;16)/der(1;16)in middle-aged patients with hyperplasia of mammary glands. Jpn J Cancer Res, 91:692-699, 2000 9. Araki N, Hatae T, Yamada T, Hirohashi S. Actinin-4 is preferentially involved in circular ruffling and macropinocytosis in mouse macrophages: analysis by fluorescence ratio imaging. J Cell Sci, 113:3329- 3340, 2000 10. Maruyama K, Ochiai A, Akimoto S, Nakamura S, Baba S, Moriya Y, Hirohashi S. Cytoplasmic b-catenin accumulation as a predictor of hematogenous metastasis in human colorectal cancer. Oncology, 59:302-309, 2000 11. Zhu X, Kanai Y, Saito A, Kondo Y, Hirohashi S. Aberrant expression of b-catenin and mutation of exon 3 of the b-catenin gene in renal and urothelial carcinomas. Pathol Int, 50:945- 952, 2000 12. Kondo Y, Kanai Y, Sakamoto M, Mizokami M, Ueda R, Hirohashi S. Genetic instability and aberrant DNA methylation in chronic hepatitis and cirrhosis: a comprehensive study of loss of heterozygosity and microsatellite instability at 39 loci and DNA hypermethylation on 8 CpG islands in microdissected specimens from patients with hepatocellular carcinoma. Hepatology, 32:970-979, 2000 13. Kanai Y, Ushijima S, Tsuda H, Sakamoto M, Hirohashi S. Aberrant DNA methylation precedes loss of heterozygosity on chromosome 16 in chronic hepatitis and liver cirrhosis. Cancer Lett, 148:73- 80, 2000 14. Yamada T, Takaoka AS, Naishiro Y, Hayashi R, Maruyama K, Maesawa C, Ochiai A, Hirohashi S. Transactivation of the multidrug resistance 1 3241 by T-cell factor 4/b-catenin complex in early colorectal carcinogenesis. Cancer Res, 60:4761- 4766, 2000 15. Genda T, Sakamoto M, Ichida T, Asakura H, Hirohashi S. Loss of cell-cell contact is induced by integrin-mediated cell-substratum adhesion in highly-motile and highly-metastatic hepatocellular carcinoma cells. Lab Invest, 80:387- 394, 2000 16. Hasegawa T, Seki K, Hasegawa F, Matsuno Y, Shimoda T, Hirose T, Sano T, Hirohashi S. Dedifferentiated liposarcoma of retroperitoneum and mesentery: varied growth patterns and histological grades: a clinicopathologic study of 32 cases. Hum Pathol, 31:717-727, 2000 17. Okano K, Yamamoto J, Kosuge T, Yamamoto S, Sakamoto M, Nakanishi Y, Hirohashi S. Fibrous pseudocapsule of metastatic liver tumors from colorectal carcinoma: clinicopathologic study of 152 first resection cases. Cancer, 89:267-275, 2000 18. Tajima Y, Nakanishi Y, Ochiai A, Tachimori Y, Kato H, Watanabe H, Yamaguchi H, Yoshimura K, Kusano M, Shimoda T. Histopathologic findings predicting lymph node metastasis and prognosis of patients with superficial esophageal carcinoma. Cancer, 88:1285-1293, 2000 19. Tajima Y, Nakanishi Y, Tachimori Y, Kato H, Watanabe H, Yamaguchi H, Yoshimura K, Kusano M, Shimoda T. Significance of involvement by squamous cell carcinoma of the ducts of esophageal submucosal glands: analysis of 201 surgically resected superficial squamous cell carcinomas. Cancer, 89:248-254, 2000 20. Fujii K, Moriya Y, Fujita S, Akasu T, Miyake H, Nakanishi Y, Saito T. Dermatomyositis accompanied by rectal cancer: report of a case. Surg Today, 30:302-304, 2000 21. Gotoda T, Matsumura Y, Kondo H, Ono H, Kanamoto A, Kato H, Watanabe H, Tachimori Y, Nakanishi Y, Kakizoe T. Expression of CD44 variants and prognosis in oesophageal squamous cell carcinoma. Gut, 46:14-19, 2000 22. Hasegawa T, Seki K, Ono K, Hirohashi S. Angiomatoid (malignant) fibrous histiocytoma: a peculiar low-grade tumor showing immunophenotypic heterogeneity and ultrastructural variations. Pathol Int, 50:731-738, 2000 23. Hasegawa T, Yokoyama R, Lee YH, Shimoda T, Beppu Y, Hirohashi S. Prognostic relevance of a histological grading system using MIB-1 for adult soft-tissue sarcoma. Oncology, 58:66-74, 2000 24. Kato H, Igaki H, Tachimori Y, Watanabe H, Tsubosa Y, Nakanishi Y. Assessment of cervical lymph node metastasis in the staging of thoracic esophageal carcinoma. J Surg Oncol, 74:282-285, 2000 25. Okusaka T, Okada S, Ueno H, Ikeda M, Yoshimori M, Shimada K, Yamamoto J, Kosuge T, Yamasaki S, Iwata R, Furukawa H, Moriyama N, Sakamoto M, Hirohashi S. Evaluation of the therapeutic effect of transcatheter arterial embolization for hepatocellular carcinoma. Oncology, 58:293-299, 2000 26. Sugawara Y, Yamamoto J, Yamasaki S, Shimada K, Kosuge T, Sakamoto M. Cystic liver metastases from colorectal cancer. J Surg Oncol, 74:148-152, 2000 27. Takayama T, Sekine T, Makuuchi M, Yamasaki S, Kosuge T, Yamamoto J, Shimada K, Sakamoto M, Hirohashi S, Ohashi Y, Kakizoe T. Adoptive immunotherapy to lower postsurgical recurrence rates of hepatocellular carcinoma: a randomised trial. Lancet, 356:802-807, 2000 28. Tanaka M, Shibui S, Nomura K, Nakanishi Y, Hasegawa T, Hirose T. Malignant intracerebral nerve sheath tumor with intratumoral calcification. J Neurosurg, 92:338-341, 2000 29. Tomaru U, Hasegawa T, Hasegawa F, Kito M, Hirose T, Shimoda T. Primary extracranial meningioma of the foot: a case report. Jpn J Clin Oncol, 30:313- 317, 2000 30. Tsuda H, Akiyama F, Kurosumi M, Sakamoto G, Watanabe T. A quantitative model using mean and standard deviation for evaluation of interobserver agreement in nuclear atypia scoring of breast carcinomas in a protocol study. Pathol Int, 50:119-125, 2000 31. Tsuda H, Akiyama F, Kurosumi M, Sakamoto G, Yamashiro K, Oyama T, Hasebe T, Kameyama K, Hasegawa T, Umemura S, Honma K, Ozawa T, Sasaki K, Morino H, Ohsumi S. Evaluation of the interobserver agreement in the number of mitotic figures of breast carcinoma as simulation of quality monitoring in the Japan National Surgical Adjuvant Study of Breast Cancer (NSAS- BC) protocol. Jpn J Cancer Res, 91:451-457, 2000 32. Tsuda H, Okada S, Kasamatsu T. Is florid pyloric metaplasia different from adenoma malignum? Gynecol Oncol, 77:341-342, 2000 33. Tsuda H, Takarabe T, Akashi-Tanaka S, Fukutomi T, Nanasawa T, Watanabe T. Evaluation of histopathological criteria for identifying node-negative breast cancer with high risk of early recurrence in the NSAS-BC protocol study. Breast Cancer, 7:201-209, 2000 34. Tsuda H, Takarabe T, Hasegawa F, Fukutomi T, Hirohashi S. Large, central acellular zones indicating myoepithelial tumor differentiation in high-grade invasive ductal carcinomas as markers of predisposition to lung and brain metastases. Am J Surg Pathol, 24:197-202, 2000 35. Yatabe Y, Suzuki R, Tobinai K, Matsuno Y, Ichinohasama R, Okamoto M, Yamaguchi M, Tamaru J, Uike N, Hashimoto Y, Morishima Y, Suchi T, Seto M, Nakamura S. Significance of cyclin D1 overexpression for the diagnosis of mantle cell lymphoma: a clinicopathologic comparison of cyclin D1-positive MCL and cyclin D1-negative MCL-like B-cell lymphoma. Blood, 95:2253-2261, 2000 36. Wada T, Hasegawa T, Nagoya S, Kawaguchi S, Kaya M, Ishii S. Myxofibrosarcoma with an infiltrative growth pattern: a case report. Jpn J Clin Oncol, 30:458-462, 2000 37. Igaki H, Kato H, Tachimori Y, Nakanishi Y. Cervical lymph node metastasis in patients with submucosal carcinoma of the thoracic esophagus. J Surg Oncol, 75:37-41, 2000 38. Kanamoto A, Nakanishi Y, Ochiai A, Shimoda T, Yamaguchi H, Tachimori Y, Kato H, Watanabe H. A case of small polypoid esophageal carcinoma with multidirectional differentiation, including neuroendocrine, squamous, ciliated glandular, and sarcomatous components. Arch Pathol Lab Med, 124:1685-1687, 2000 39. Hokamura N, Kato H, Tachimori Y, Watanabe H, Yamaguchi H, Nakanishi Y. Preoperative chemotherapy for esophageal carcinoma with intramural metastasis. J Surg Oncol, 75:117-121, 2000 2. Biochemistry Division 40. Nagao M, Sugimura T. Perspectives. In: Nagao M, Sugimura T (eds), Food Borne Carcinogens. Chichester, John Wiley & Sons Ltd., pp 361-364, 2000 41. Nagao M. Mutagenicity. In: Nagao M, Sugimura T (eds), Food Borne Carcinogens. Chichester, John Wiley & Sons Ltd., pp 163-195, 2000 42. Nakagama H. Carciogenesis in animals and specific organs 7. IV Colon. In: Nagao M, Sugimura T (eds), Food Borne Carcinogens. Chichester, John Wiley &Sons Ltd., pp 256-269, 2000 43. Burnouf D, Miturski R, Nagao M, Nakagama H, Nothisen M, Wagner J, Fuchs RPP. Molecular approach in cancer epidemiology: early detection of carcinogen-induced mutations in a whole genome (review). Int J Mol Med, 5:15-20, 2000 44. Nagao M. A new approach to risk estimination of food-borne carcinogens - heterocyclic amines - based on molecular information. Mutat Res, 431:3-12, 1999 45. Shirato H, Shima H, Nakagama H, Fukuda H, Watanabe Y, Ogawa K, Matsuda Y, Kikuchi K. Expression in hepatomas and chromosomal localization of rat protein phosphatase 5 gene. Int J Oncol, 17:909-912, 2000 46. Masutani M. Post-translational modification: poly(ADP-ribosyl)ation. Seitai no Kagaku, 51:368, 2000 47. Masutani M, Nozaki T, Nakamoto K, Nakagama H, Suzuki H, Kusuoka O, Tsutsumi M, Sugimura T. The response of Parp knockout mice against DNA damaging agents. Mutat Res, 462:159-166, 2000 48. Nagasawa S, Shimokawa T, Masutani M, Nozaki T, Wakabayashi K, Nakagama H, Sugimura T. Phylogenic distribution of poly(ADP-ribose)glycohydrolase and poly(ADP-ribose)-digesting phosphodiesterase. Proc Jpn Acad Ser B, 76:41-44, 2000 3. Experimental Pathology and Chemotherapy Division 49. Asamoto M, Ochiya T, Toriyama-Baba H, Ota T, Sekiya T, Terada M, Tsuda H. Transgenic rats carrying human c-Ha-ras proto-oncogenes are highly susceptible to N-methyl-N-nitrosourea mammary carcinogenesis. Carcinogenesis, 21:243- 249, 2000 50. Ota T, Asamoto M, Toriyama-Baba H, Yamamoto F, Matsuoka Y, Ochiya T, Sekiya T, Terada M, Akaza H, Tsuda H. Transgenic rats carrying copies of the human c-Ha-ras proto-oncogene exhibit enhanced susceptibility to N-butyl-N-(4- hydroxybutyl)nitrosamine bladder carcinogenesis. Carcinogenesis, 21:1391-1396, 2000 51. Masuda C, Wanibuchi H, Sekine K, Yano Y, Otani S, Kishimoto T, Tsuda H, Fukushima S. Chemopreventive effects of bovine lactoferrin on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced rat bladder carcinogenesis. Jpn J Cancer Res, 91:582-588, 2000 52. Tanaka T, Kawabata K, Kohno H, Honjo S, Murakami M, Ota T, Tsuda H. Chemopreventive effect of bovine lactoferrin on 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in male F344 rats. Jpn J Cancer Res, 91:25-33, 2000 53. Tanaka T, Kawabata K, Kohno H, Honjo S, Murakami M, Shimada R, Kagami S, Tsuda H. Bovine lactoferrin inhibits rat tongue carcinogenesis. In: Shimazaki K, Tsuda H, Tomita M, Kuwata T, Perraudin J-P (eds), Proceedings of the 4th international conference on lactoferrin: structure, function and applications. Tokyo, Elsevier Science, pp 401-411, 2000 54. Tsuda H, Sekine K, Ushida Y, Kuhara T, Takasuka N, Iigo M, Han BS, Moore MA. Milk and dairy products in cancer prevention: focus on bovine lactoferrin. Mutat Res, 462:227-233, 2000 55. Shimizu N, Ikehara Y, Nozaki K, Kaminishi M, Tsuda H, Sugiyama A, Katsuyama T, Tatematsu M. Effects of lactoferrin administration in Helicobacter pylori infection animal model. In: Shimazaki K, Tsuda H, Tomita M, Kuwata T, Perraudin J-P (eds), Proceedings of the 4th international conference on lactoferrin: structure, function and applications. Tokyo, Elsevier Science, pp 209-215, 2000 56. Wang W-P, Iigo M, Sato J, Sekine K, Adachi I, Tsuda H. Activation of intestinal mucosal immunity in tumor-bearing mice by lactoferrin. Jpn J Cancer Res, 91:1022-1027, 2000 57. Maeda M, Iigo M, Tsuda H, Fujita H, Yonemura Y, Nakagawa K, Endo Y, Sasaki T. Antimetastatic and antitumor effects of 2,4-diamino-6-(pyridine-4-yl)-1,3,5-triazine(4PyDAT) on the high lung metastatic colon 26 tumor in mice. Anticancer Drug Des, 15:217-223, 2000 58. Krutovskikh VA, Troyanovsky SM, Piccoli C, Tsuda H, Asamoto M, Yamasaki H. Differential effect of subcellular localization of communication impairing gap junction protein connexin43 on tumor cell growth in vivo. Oncogene, 19:505-513, 2000 59. Goldberg GS, Bechberger JF, Tajima Y, Merritt M, Omori Y, Gawinowicz MA, Narayanan R, Tan Y, Sanai Y, Yamasaki H, Naus CCG, Tsuda H, Nicholson BJ. Connexin43 suppresses MFG-E8 while inducing contact growth inhibition of glioma cells. Cancer Res, 60:6018-6026, 2000 60. Matsuoka Y, Li X, Bennett V. Adducin: structure, function and regulation. Cell Mol Life Sci, 57:884-895, 2000 4. Biology Division 61. Hamada K, Kohno T, Takahashi M, Yamazaki M, Tashiro H, Sugawara C, Ohwada S, Sekido Y, Minna JD, Yokota J. Two regions of homozygous deletion clusters at chromosome band 9p21 in human lung cancer. Genes Chromosom Cancer, 27:308-318, 2000 62. Saito M, Okamoto A, Kohno T, Takakura S, Shinozaki H, Isonishi S, Yasuhara T, Yoshimura T, Ohtake Y, Ochiai K, Yokota J, Tanaka T. Allelic imbalance and mutations of the PTEN gene in ovarian cancer. Int J Cancer, 85:160-165, 2000 63. Shimizu S, Suzukawa K, Kodera T, Nagasawa T, Abe T, Taniwaki M, Yagasaki F, Tanaka H, Fujisawa S, Johansson B, Ahlgren T, Yokota J, Morishita K. Identification of breakpoint cluster regions at 1p36.3 and 3q21 in hematologic malignancies with t(1;3)(p36;q21). Genes Chromosom Cancer, 27:229-238, 2000 64. Takita J, Hayashi Y, Takei K, Yamaguchi N, Hanada R, Yamamoto K, Yokota J. Allelic imbalance on chromosome 18 in neuroblastoma. Eur J Cancer, 36:508-513, 2000 65. Yamada T, Kohno T, Navarro JM, Ohwada S, Perucho M, Yokota J. Frequent chromosome 8q gains in human small cell lung carcinoma detected by arbitrarily primed-PCR genomic fingerprinting. Cancer Genet Cytogenet, 120:11-17, 2000 66. Mochizuki N, Shimizu S, Nagasawa T, Tanaka H, Taniwaki M, Yokota J, Morishita K. A novel gene, MEL1, mapped to 1p36.3 is highly homologous to the MDS1/EVI1 gene and is transcriptionally activated in t(1;3)(p36;q21)-positive leukemia cells. Blood, 96:3209-3214, 2000 67. Hamada K, Koyama T, Shimizu K, Ikawa S, Kawate S, Yokota J, Ohwada S, Morishita Y. Absence of p51 mutation in human hepatocellular carcinoma. Cancer Lett, 148:161-164, 2000 68. Inoue K, Kohno T, Takakura S, Hayashi Y, Mizoguchi H, Yokota J. Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines. Leuk Res, 24:255-262, 2000 69. Kohno T, Sato T, Takakura S, Takei K, Inoue K, Nishioka M, Yokota J. Mutation and expression of the DCC gene in human lung cancer. Neoplasia, 2:300-305, 2000 70. Manda R, Kohno T, Hamada K, Takenosita S, Kuwano H, Yokota J. Absence of hSNF5/INI1 mutation in human lung cancer. Cancer Lett, 153:57-61, 2000 71. Takakura S, Kohno T, Shimizu K, Ohwada S, Okamoto A, Yokota J. Somatic mutations and genetic polymorphisms of the PPP1R3 gene in patients with several types of cancers. Oncogene, 19:836-840, 2000 72. Inoue K, Kohno T, Takakura S, Morishita K, Takita J, Hayashi Y, Mizoguchi H, Yokota J. Alterations of the PPP1R3 gene in hematological malignancies. Int J Oncol, 17:717-721, 2000 73. Shieh S-Y, Ahn J, Tamai K, Taya Y, Prives C. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev, 14:289-300, 2000 74. Chan DW, Son S-C, Block W, Ye R, Khanna KK, Wold MS, Douglas P, Goodarzi AA, Pelley J, Taya Y, Lavin MF, Lees-Miller SP. Purification and characterization of ATM from human placenta. J Biol Chem, 275:7803-7810, 2000 75. Pandita TK, Lieberman HB, Lim D-S, Dhar S, Zheng W, Taya Y, Kastan MB. Ionizing radiation activates the ATM kinase throughout the cell cycle. Oncogene, 19:1386-1391, 2000 76. Ashcroft M, Taya Y, Vousden KH. Stress signals utilize multiple pathways to stabilize p53. Mol Cell Biol, 20:3224-3233, 2000 77. Xiao G, Chicas A, Olivier M, Taya Y, Tyagi S, Kramer FR, Bargonetti J. A DNA damage signal is required for p53 to activate gadd45. Cancer Res, 60:1711-1719, 2000 78. Kapoor M, Hamm R, Yan W, Taya Y, Lozano G. Cooperative phosphorylation at multiple sites is required to activate p53 in response to UV radiation. Oncogene, 19:358-364, 2000 79. Ariumi Y, Kaida A, Lin J-Y, Hirota M, Masui O, Yamaoka S, Taya Y, Shimotohno K. HTLV-1 Tax oncoprotein represses the p53-mediated trans-activation function through coactivator CBP sequestration. Oncogene, 19:1491-1499, 2000 80. Oda K, Arakawa H, Tanaka T, Matsuda K, Tanikawa C, Mori T, Nishimori H, Tamai K, Tokino T, Nakamura Y, Taya Y. p53A/P1, a potential mediator of p53- dependent apoptosis, and its regulation by ser-46-phosphorylated p53. Cell, 102:849-862, 2000 81. Shimizu K, Nagamachi Y, Tani M, Kimura K, Shiroishi T, Wakana S, Yokota J. Molecular cloning of a novel NF2/ERM/4.1 superfamily gene, Ehm2, that is expressed in high-metastatic K1735 murine melanoma cells. Genomics, 65:113-120, 2000 82. Yokota J. Tumor progression and metastasis. Carcinogenesis, 21:497-503, 2000 83. Manda R, Kohno T, Niki T, Yamada T, Takenoshita S, Kuwano H, Yokota J. Differential expression of the LAMB3 and LAMC2 genes between small cell and non-small cell lung carcinomas. Biochem Biophys Res Commun, 275:440-445, 2000 84. Shinmura K, Kohno T, Takeuchi-Sasaki M, Maeda M, Segawa T, Kamo T, Sugimura H, Yokota J. Expression of the OGG1-type 1a (nuclear form) protein in cancerous and non-cancerous human cells. Int J Oncol, 16:701-707, 2000 85. Shinmura K, Yamaguchi S, Saitoh T, Takeuchi-Sasaki M, Kim S-R, Nohmi T, Yokota J. Adenine excisional repair function of MYH protein on the adenine: 8-hydroxyguanine base pair in double-stranded DNA. Nucleic Acids Res, 28:4912-4918, 2000 86. Park J-G, Yang H-K, Kim WH, Caldas C, Yokota J, Guilford PJ. Report on the first meeting of the International Collaborative Group on hereditary gastric cancer. J Natl Cancer Inst, 92:1781-1782, 2000 87. Kimura K, Shinmura K, Yoshimura K, Shimizu K, Katai H, Beppu Y, Moriya H, Yokota J. Absence of germline CHK2 mutations in familial gastric cancer. Jpn J Cancer Res, 91:875-879, 2000 5. Pharmacology Division 88. Azuma M, Kato K, Ikarashi Y, Asada-Mikami R, Maruoka H, Takaue Y, Saito A, Wakasugi H. Cytokines production of U5A2-13-positive T cells by stimulation with glycolipid a-galactosylceramide. Eur J Immunol, 30:2138-2146, 2000 89. Tajima J, Heike Y, Kato K, Ikarashi Y, Asada-Mikami R, Yoshida M, Kasahara T, Wakasugi H. Establishment and usefulness of an anti-human CD57 IgG1 monoclonal antibody. Immunol Lett, 72:159-162, 2000 90. Wakasugi H, Yamaguchi N. Teleconferences between the Gustave- Roussy Institute (Villejuif, France) and the National Cancer Center (Tokyo, Japan) as a new bilateral cooperative activity. Jpn J Cancer Res, 91:135-137, 2000 91. Saijo N, Tamura T, Nishio K. Problems in the development of target-based drugs. Cancer Chemother Pharmacol, 46:S43-S45, 2000 92. Fukumoto H, Tamura T, Kamiya Y, Usuda J, Suzuki T, Fumihiko K, Kuh H-J, Ohe Y, Saijo N, Nishio K. Activation-induced apoptosis of peripheral lymphocytes treated with 7-hydroxystaurosporine, UCN- 01. Invest New Drugs, 17:335-341, 1999 93. Fukuoka K, Nishio K, Fukumoto H, Arioka H, Kurokawa H, Ishida T, Iwamoto Y, Tomonari A, Suzuki T, Usuda J, Narita N, Saijo N. Ectopic P16INK4 expression enhances CPT-11-induced apoptosis through increased delay in S-phase progression in human non-small-cell-lung-cancer cells. Int J Cancer, 86:197-203, 2000 94. Usuda J, Saijo N, Fukuoka K, Fukumoto H, Kuh H-J, Nakamura T, Koh Y, Suzuki T, Koizumi F, Tamura T, Kato H, Nishio K. Molecular determinants of UCN-01-induced growth inhibition in human lung cancer cells. Int J Cancer, 85:275-280, 2000 95. Fukuoka K, Yamagishi T, Ichihara T, Nakaike S, Iguchi K, Yamada Y, Fukumoto H, Yoneda T, Samata K, Ikeya H, Nanaumi K, Hirayama N, Narita N, Saijo N, Nishio K. Mechanism of action of aragusterol A (YTA0040), a potent anti-tumor marine steroid targeting the G1 phase of the cell cycle. Int J Cancer, 88:810-819, 2000 96. Kuh H-J, Nakagawa S, Usuda J, Yamaoka K, Saijo N, Nishio K. A computational model for quantitative analysis of cell cycle arrest and its contribution to overall growth inhibition by anticancer agents. Jpn J Cancer Res, 91:1303-1313, 2000 97. Oshita F, Kameda Y, Nishio K, Tanaka G, Yamada K, Nomura I, Nakayama H, Noda K. Increased expression levels of cyclin-dependent kinase inhibitor p27 correlate with good responses to platinum-based chemotherapy in non-small cell lung cancer. Oncol Rep, 7:491-495, 2000 98. Oshita F, Nishio K, Kameda Y, Mitsuda A, Ikehara M, Tanaka G, Yamada K, Nomura I, Noda K, Arai H, Ito H, Nakayama H. Increased expression levels of p53 correlate with good response to cisplatin-based chemotherapy in non-small cell lung cancer. Oncol Rep, 7:1225-1228, 2000 99. Suzuki T, Sasaki H, Kuh H-J, Agui M, Tatsumi Y, Tanabe S, Terada M, Saijo N, Nishio K. Detailed structural analysis on both human MRP5 and mouse mrp5 transcripts. Gene, 242:167-173, 2000 100. Oguri T, Isobe T, Suzuki T, Nishio K, Fujiwara Y, Katoh O, Yamakido M. Increased expression of the MRP5 gene is associated with exposure to platinum drugs in lung cancer. Int J Cancer, 86:95-100, 2000 6. Biophysics Division 101. Noguchi K, Yamana H, Kitanaka C, Mochizuki T, Kokubu A, Kuchino Y. Differential role of the JNK and p38 MAPK pathway in c-Myc- and s-Myc-mediated apoptosis. Biochem Biophys Res Commun, 267:221-227, 2000 102. Narita Y, Asai A, Kuchino Y, Kirino T. Actinomycin D and staurosporine, potent apoptosis inducers in vitro, are potentially effective chemotherapeutic agents against glioblastoma multiforme. Cancer Chemother Pharmacol, 45:149-156, 2000 103. Nagane M, Asai A, Shibui S, Oyama H, Nomura K, Kuchino Y. Expression pattern of chemoresistance-related genes in human malignant brain tumors:a working knowledge for proper selection of anticancer drugs. Jpn J Clin Oncol, 29:527- 534, 1999 104. Kaneko M, Inoue F, Oda T. Calcium associated resistance to H2O2 in Chinese hamster V79 cells. Toxicol Lett, 115:137-147, 2000 105. Watanabe S, Muramatsu T, Ao H, Hirayama Y, Takahashi K, Tanokura M, Kuchino Y. Molecular cloning of the Lon protease gene from Thermus thermophilus HB8 and characterization of its gene product. Eur J Biochem, 266:811-819, 1999 7. Growth Factor Division 106. Ohkubo T, Ohkura N, Maruyama K, Sasaki K, Nagasaki K, Hanzawa H, Tsukada T, Yamaguchi K. Early induction of the orphan nuclear receptor NOR-1 during cell death of the human breast cancer cell line MCF-7. Mol Cell Endocrinol, 162:151-156, 2000 107. Maruyama K, Tsukada T, Honda M, Nara-Ashizawa N, Noguchi K, Cheng J, Ohkura N, Sasaki K, Yamaguchi K. Complementary DNA structure and genomic organization of Drosophila menin. Mol Cell Endocrinol, 168:135-140, 2000 108. Tsukada T, Kishi M, Obara T, Yamaguchi K. An intronic splicing mutation of the MEN1 gene. Int J Cancer, 87:305-307, 2000 109. Honda M, Tsukada T, Tanaka H, Maruyama K, Yamaguchi K, Obara T, Yamaji T, Ishibashi M. A novel mutation of the MEN1 gene in a Japanese kindred with familial isolated primary hyperparathyroidism. Eur J Endocrinology, 142:138-143, 2000 110. Iwashita T, Murakami H, Kurokawa K, Kawai K, Miyauchi A, Futami H, Qiao S, Ichihara M, Takahashi M. A two-hit model for development of multiple endocrine neoplasia type 2B by RET mutations. Biochem Biophys Res Commun, 268:804-808, 2000 111. Miyauchi A, Matsuzuka F, Hirai K, Yokozawa T, Kobayashi K, Kuma S, Kuma K, Futami H, Yamaguchi K. Unilateral surgery supported by germline RET oncogene mutation analysis in patients with sporadic medullary thyroid carcinoma. World J Surg, 24:1367-1372, 2000 8. Cancer Genomics Division 112. Ohira M, Kageyama H, Mihara M, Furuta S, Machida T, Shishikura T, Takayasu H, Islam A, Nakamura Y, Takahashi M, Tomioka N, Sakiyama S, Kaneko Y, Toyoda A, Hattori M, Sakaki Y, Ohki M, Horii A, Soeda E, Inazawa J, Seki N, Kuma H, Nozawa I, Nakagawara A. Identification and characterization of a 500-kb homozygously deleted region at 1p36.2-p36.3 in a neuroblastoma cell line. Oncogene, 19:4302-4307, 2000 113. Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Shibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brandt P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Bloker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML (Tcmas). The DNA sequence of human chromosome 21. Nature, 405:311-319, 2000 114. Kitabayashi I, Aikawa Y, Yokoyama A, Hosoda F, Nagai M, Kakazu N, Abe T, Ohki M. Fusion of MOZ and p300 histone acetyltransferases in acute monocytic leukemia with a t(8;22)(p11;q13) chromosome translocation. Leukemia, 15:89-94, 2001 115. Morohoshi F, Mitani S, Mitsuhashi N, Kitabayashi I, Takahashi E, Suzuki N, Ohki M. Structure and expression pattern of a human MTG8/ETO family gene,MTGR1. Gene, 241:287-295, 2000 116. Shimizu K, Kitabayashi I, Kamada N, Abe T, Maseki N, Suzukawa K, Ohki M. AML1-MTG8 leukemic protein induces the expression of granulocyte colony-stimulating factor (G-CSF) receptor through the up-regulation of CCAAT/enhancer binding protein epsilon. Blood, 96:288-296, 2000 117. Shimada H, Ichikawa H, Nakamura S, Katsu R, Iwasa M, Kitabayashi I, Ohki M. Analysis of genes under the downstream control of the t(8;21) fusion protein AML1-MTG8: overexpression of the TIS11b(ERF-1,cMG1) gene induces myeloid cell proliferation in response to G-CSF. Blood, 96:655-663, 2000 9. Cancer Information and Epidemiology Division 118. Katai H, Yoshimura K, Maruyama K, Sasako M, Sano T. Evaluation of the new international union against cancer TNM staging for gastric carcinoma. Cancer, 88:1796-1800, 2000 119. Mizushima H, Uchiyama E, Nagata H, Yamaguchi N. Telemedicine comes of age. Jpn J Clin Oncol, 30:3-6, 2000 120. Kido C, Sasaki F, Hirota Y, Kiyosawa K, Hayashi S, Mori T, Sobue T. Cancer mortality of thorotrast patients in Japan: the second series updated 1998. Radiat Res, 152:S81S83, 1999 121. Mori T, Kido C, Fukutomi K, Kato Y, Hatakeyama S, Machinami R, Ishikawa Y, Kumatori T, Sasaki F, Hirota Y, Kiyosawa K, Hayashi S, Tanooka H, Sobue T. Summary of entire Japanese thorotrast follow-up study: updated 1998. Radiat Res, 152:S84-S87, 1999 122. Sobue T, Lee VS, Ye W, Tanooka H, Mifune M, Suyama A, Koga T, Morishima H, Kondo S. Residential radon exposure and lung cancer risk in Misasa, Japan: a case-control study. J Radiat Res, 41:81-92, 2000 123. Yamaguchi N, Kinjo Y, Akiba S, Watanabe S. Ultraviolet radiation and health: from hazard identification to effective prevention. J Epidemiol, 9:S1-S4, 1999 124. Araki K, Nagano T, Ueda M, Washio F, Watanabe S, Yamaguchi N, Ichihashi M. Incidence of skin cancers and precancerous lesions in Japanese: risk factors and prevention. J Epidemiol, 9:S14-S21, 1999 125. Takahashi K, Pan G, Feng Y, Ohtaki M, Watanabe S, Yamaguchi N. Regional correlation between estimated UVB levels and skin cancer mortality in Japan. J Epidemiol, 9:S123-S128, 1999 126. Akiba S, Shinkura R, Miyamoto K, Hillebrand G, Yamaguchi N, Ichihashi M. Influence of chronic UV exposure and lifestyle on facial skin photo-aging: results from a pilot study. J Epidemiol, 9:S136-S142, 1999 127. Yamaguchi N. Uncertainty in risk characterization of weak carcinogens. Ann N Y Acad Sci, 895:338-347, 1999 128. Takeshita T, Morimoto K, Yamaguchi N, Watanabe S, Todoroki I, Honjo S, Nakagawa K, Kono S. Relationships between cigarette smoking, alcohol drinking, the ALDH2 genotype and adenomatous types of colorectal polyps in male self-defense force officials. J Epidemiol, 10:366-371, 2000 129. Sobue T. Non-traditional study designs in the analysis of gene-environment interactions. Jpn J Clin Oncol, 29:460-461, 1999 130. Sobue T. A case-control study for evaluating lung cancer screening in Japan. Cancer, 89:2392-2396, 2000 131. Yamamoto S, Sobue T, Yamaguchi N, Yamamoto S, Kikui M, Kusunoki Y, Oshima A, Hanai A. Reproducibility of diagnosis and its influence on the distribution of lung cancer by histologic type in Osaka, Japan. Jpn J Cancer Res, 91:1-8, 2000 132. Yoshimura K. The psychological characteristics of tobacco dependence in a rural area of Japan. J Epidemiol, 10:271-279, 2000 133. Ono Y, Ando J, Onoda N, Yoshimura K, Kanba S, Hirano M, Asai M. Genetic structure of the five-factor model of personality in a Japanese twin population. Keio J Med, 49:152-158, 2000 134. Ono Y, Yoshimura K, Yamauchi K, Asai M, Young J, Fujihara S, Kitamura T. Somatoform symptoms in a Japanese community population:prevalence and association with personality characteristics. Transcult Psychiatry, 37:217-227, 2000 135. Takenaka T, Shirakawa S, Mikuni C, Sai T, Shimamoto Y, Araki K, Hirano M, Miura A, Ohno Y, Ichimaru M, Hanada S, Inaba S, Konishi H, Toki H, Tajima K, Niimi M, Fukuda H, Shimoyama M, the lymphoma study group of the Japan Clinical Oncology Group (JCOG). Alternating combination chemotherapy COP (cyclophosphamide, vincristine, prednisone) and MP (melphalan, prednisone) in multiple myeloma: a multicenter phase II study (JCOG8906). Jpn J Clin Oncol, 29:485-489, 1999 136. Kawahara K, Ohida T, Osaki Y, Mochizuki Y, Minowa M, Yamaguchi N, Kusaka Y. Study of the smoking behavior of medical doctors in Fukui,Japan and their anti-smoking measures. J Epidemiol, 10:157-162, 2000 137. Yamaguchi N, Mochizuki-Kobayashi Y, Utsunomiya O. Quantitative relationship between cumulative cigarette consumption and lung cancer mortality in Japan. Int J Epidemiol, 29:963-968, 2000 10. Virology and Glycobiology Division 138. Matsuda K, Li J-L, Ichinose S, Harasawa R, Saito M, Yamamoto N. Monoclonal antibody against mycoplasma fermentans-specific aminoglycoglycerolipid. Microbiol Immunol, 44:695-702, 2000 139. Nakamoto T, Yamagata T, Sakai R, Ogawa S, Honda H, Ueno H, Hirano N, Yazaki Y, Hirai H. CIZ, a zinc finger protein that interacts with p130cas and activates the expression of matrix metalloproteinases. Mol Cell Biol, 20:1649-1658, 2000 140. Sakai R, Henderson JT, O 'Bryan JP, Elia AJ, Saxton TM, Pawson T. The mammalian ShcB and ShcC phosphotyrosine docking proteins function in the maturation of sensory and sympathetic neurons. Neuron, 28:819-833, 2000 141. Ikeda M, Nozaki A, Sugiyama K, Tanaka T, Naganuma A, Tanaka K, Sekihara H, Shimotohno K, Saito M, Kato N. Characterization of antiviral activity of lactoferrin against hepatitis C virus infection in human cultured cells. Virus Res, 66:51-63, 2000 142. Ikeda M, Sugiyama K, Tanaka T, Nozaki A, Naganuma A, Tanaka K, Sekihara H, Shimotohno K, Saito M, Kato N. Antiviral activity of lactoferrin against HCV infection in human cultured cells. In: Shimazaki K (eds), Lactoferrin: Structure, Function and Applications. Tokyo, Elsevier Science, pp 225-232, 2000 143. Tanaka T, Sugiyama K, Ikeda M, Naganuma A, Nozaki A, Saito M, Shimotohno K, Kato N. Hepatitis C virus NS5B RNA replicase specifically binds ribosomes. Microbiol Immunol, 44:543-550, 2000 11. Cancer Prevention Division 144. Shiozawa T, Tada A, Nukaya H, Watanabe T, Takahashi Y, Asanoma M, Ohe T, Sawanishi H, Katsuhara T, Sugimura T, Wakabayashi K, Terao Y. Isolation and identification of a new 2-phenylbenzotriazole-type mutagen (PBTA-3) in the Nikko River in Aichi, Japan. Chem Res Toxicol, 13:535-540, 2000 145. Matsuoka A, Sakamoto H, Tadokoro S, Tada A, Terao Y, Nukaya H, Wakabayashi K. The 2-phenylbenzotriazole-type water pollutant PBTA-2 has cytochalasin B-mimetic activity. Mutat Res, 464:161-167, 2000 146. Watanabe T, Goto S, Matsumoto Y, Asanoma M, Hirayama T, Sera N, Takahashi Y, Endo O, Sakai S, Wakabayashi K. Mutagenic activity of surface soil and quantification of 1,3- , 1,6- , and 1,8-dinitropyrene isomers in soil in Japan. Chem Res Toxicol, 13:281-286, 2000 147. Nakano K, Suyama K, Fukazawa H, Uchida M, Wakabayashi K, Shiozawa T, Terao Y. Chlorination of harman and norharman with sodium hypochlorite and co-mutagenicity of the chlorinated products. Mutat Res, 470:141-146, 2000 148. Felton JS, Jagerstad M, Knize MG, Skog K, Wakabayashi K. Contents in foods, beverages and tobacco. In: Nagao M, Sugimura T (eds), Food Borne Carcinogens. Chichester, John Wiley & Sons Ltd., pp 31-71, 2000 149. Wakabayashi K. Human exposure based on DNA adduct levels. In: Nagao M, Sugimura T (eds), Food Borne Carcinogens. Chichester, John Wiley & Sons Ltd., pp 314-318, 2000 150. Imaida K, Ogawa K, Takahashi S, Ito T, Yamaguchi T, Totsuka Y, Wakabayashi K, Tanaka K, Ito N, Shirai T. Delay of DNA-adduct repair and severe toxicity in xeroderma pigmentosum group A gene (XPA) deficient mice treated with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Cancer Lett, 150:63- 69, 2000 151. Sugimura T, Nagao M, Wakabayashi K. Complex factors pertinent to human hazard risk. In: Nagao M, Sugimura T (eds), Food Borne Carcinogens.Chichester, John Wiley & Sons Ltd., pp 349-359, 2000 152. Masumura K, Matsui K, Yamada M, Horiguchi M, Ishida K, Watanabe M, Wakabayashi K, Nohmi T. Characterization of mutations induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in the colon of gpt delta transgenic mouse: novel G:C deletions beside runs of identical bases.Carcinogenesis, 21:2049-2056, 2000 153. Sugimura T, Nagao M, Wakabayashi K. How we should deal with unavoidable exposure of man to environmental mutagens: cooked food mutagen discovery, facts and lessons for cancer prevention. Mutat Res, 447:15-25, 2000 154. Tanigawa T, Kawamori T, Iimuro M, Ohta T, Higuchi K, Arakawa T, Sugimura T, Wakabayashi K. Marked enhancement by fish meal of Helicobacter pylori-induced gastritis in Mongolian gerbils. Jpn J Cancer Res, 91:769-773, 2000 155. Takahashi M, Nakatsugi S, Sugimura T, Wakabayashi K. Frequent mutations of the b-catenin gene in mouse colon tumors induced by azoxymethane. Carcinogenesis, 21:1117-1120, 2000 156. Takahashi M, Mutoh M, Kawamori T, Sugimura T, Wakabayashi K. Altered expression of b-catenin, inducible nitric oxide synthase and cyclooxygenase-2 in azoxymethane-induced rat colon carcinogenesis. Carcinogenesis, 21:1319-1327, 2000 157. Kawamori T, Takahashi M, Watanabe K, Ohta T, Nakatsugi S, Sugimura T, Wakabayashi K. Suppression of azoxymethane-induced colonic aberrant crypt foci by a nitric oxide synthase inhibitor. Cancer Lett, 148:33-37, 2000 158. Watanabe K, Kawamori T, Nakatsugi S, Ohta T, Ohuchida S, Yamamoto H, Maruyama T, Kondo K, Narumiya S, Sugimura T, Wakabayashi K. Inhibitory effect of a prostaglandin E receptor subtype EP1 selective antagonist, ONO- 8713, on development of azoxymethane-induced aberrant crypt foci in mice. Cancer Lett, 156:57-61, 2000 159. Mutoh M, Takahashi M, Fukuda K, Matsushima-Hibiya Y, Mutoh H, Sugimura T, Wakabayashi K. Suppression of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells by chemopreventive agents with a resorcin-type structure. Carcinogenesis, 21:959-963, 2000 160. Mutoh M, Takahashi M, Fukuda K, Komatsu H, Enya T, Matsushima-Hibiya Y, Mutoh H, Sugimura T, Wakabayashi K. Suppression by flavonoids of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells: structure-activity relationship. Jpn J Cancer Res, 91:686-691, 2000 161. Tsukamoto T, Tanaka H, Fukami H, Inoue M, Takahashi M, Wakabayashi K, Tatematsu M. More frequent b-catenin gene mutations in adenomas than in aberrant crypt foci or adenocarcinomas in the large intestines of 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP)-treated rats. Jpn J Cancer Res, 91:792-796, 2000 162. Fukutake M, Miura N, Yamamoto M, Fukuda K, Iijima O, Ishikawa H, Kubo M, Okada M, Komatsu Y, Sasaki H, Wakabayashi K, Ishige A, Amagaya S. Suppressive effect of the herbal medicine Oren-gedoku-to on cyclooxygenase-2 activity and azoxymethane-induced aberrant crypt foci development in rats. Cancer Lett, 157:9-14, 2000 163. Wakabayashi K. NSAIDs as cancer preventive agents. Asian Pacific J Cancer Prev, 1:97-113, 2000 164. Nakatsugi S, Ohta T, Kawamori T, Mutoh M, Tanigawa T, Watanabe K, Sugie S, Sugimura T, Wakabayashi K. Chemoprevention by nimesulide, a selective cyclooxygenase-2 inhibitor, of 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP)-induced mammary gland carcinogenesis in rats. Jpn J Cancer Res, 91:886-892, 2000 165. Ohta T, Nakatsugi S, Watanabe K, Kawamori T, Ishikawa F, Morotomi M, Sugie S, Toda T, Sugimura T, Wakabayashi K. Inhibitory effects of Bifidobacterium-fermented soy milk on 2-amino-1-methy1-6-phenylimidazo[4,5- b] pyridine-induced rat mammary carcinogenesis, with a partial contribution of its component isoflavones. Carcinogenesis, 21:937-941, 2000 166. Matsushima-Hibiya Y, Watanabe M, Kono T, Kanazawa T, Koyama K, Sugimura T, Wakabayashi K. Purification and cloning of pierisin-2, an apoptosis-inducing protein from the cabbage butterfly, Pieris brassicae. Eur J Biochem, 267:5742-5750, 2000 167. Ohyama M, Komatsu H, Watanabe M, Enya T, Koyama K, Sugimura T, Wakabayashi K. Cytotoxic phenanthroindolizidine alkaloids in Tylophora tanakae against human gastric carcinoma cells. Proc Jpn Acad, 76:161-165, 2000 12. Genetics Division 168. Saeki N, Kuwahara Y, Sasaki H, Satoh H, Shiroishi T. Gasdermin (Gsdm) localizing to mouse chromosome 11 is predominantly expressed in upper gastrointestinal tract but significantly suppressed in human gastric cancer cells. Mamm Genome, 11:718-724, 2000 169. Katoh M, Kirikoshi H, Saitoh T, Sagara N, Koike J. Alternative splicing of the WNT-2B/WNT-13 gene. Biochem Biophys Res Commun, 275:209-216, 2000 170. Kirikoshi H, Koike J, Sagara N, Saitoh T, Tokuhara M, Tanaka K, Sekihara H, Hirai M, Katoh M. Molecular cloning and genomic structure of human Frizzled-3 at chromosome 8p21. Biochem Biophys Res Commun, 271:8-14, 2000 171. Moriwaki J, Kajita E, Kirikoshi H, Koike J, Sagara N, Yasuhiko Y, Saitoh T, Hirai M, Katoh M, Shiokawa K. Isolation of Xenopus frizzled-10A and frizzled-10B genomic clones and their expression in adult tissues and embryos. Biochem Biophys Res Commun, 278:377-384, 2000 172. Koike J, Sagara N, Kirikoshi H, Takagi A, Miwa T, Hirai M, Katoh M. Molecular cloning and genomic structure of the bTRCP2 gene on chromosome 5q35.1. Biochem Biophys Res Commun, 269:103-109, 2000 173. Sagara N, Katoh M. Mitomycin C resistance induced by TCF-3 overexpression in gastric cancer cell line MKN28 is associated with DT-diaphorase down-regulation. Cancer Res, 60:5959-5962, 2000 174. Kirikoshi H, Sagara N, Saitoh T, Tanaka K, Sekihara H, Shiokawa K, Katoh M. Molecular cloning and characterization of human FGF-20 on chromosome 8p21.3-p22. Biochem Biophys Res Commun, 274:337-343, 2000 175. Quinn G, Ochiya T, Terada M, Yoshida T. Mouse flt-1 promoter directs endothelial-specific expression in the embryoid body model of embryogenesis. Biochem Biophys Res Commun, 276:1089-1099, 2000 176. Ohnishi S, Laub F, Matsumoto N, Asaka M, Ramirez F, Yoshida T, Terada M. Developmental expression of the mouse gene coding for the Kruppel-like transcription factor KLF5. Dev Dyn, 217:421-429, 2000 13. Radiobiology Division 177. Nicholson WL, Munakata N, Horneck G, Melosh HJ, Setlow P. Resistance of Bacillus endospores to extreme terrestrial and extraterrestrial environments. Microbiol Mol Biol Rev, 64:548-572, 2000 178. Munakata N, Kazadzis S, Bais A, Hieda K, Ronto G, Rettberg P, Horneck G. Comparisons of spore dosimetry and spectral photometry of solar-UV radiation at four sites in Japan and Europe. Photochem Photobiol, 72:739-745, 2000 179. Munakata N, Cornain S, Mulyadi K, Ichihashi M, Prihartono J, Ohno Y, Hamzah M, Kanoko M, Poetiray E, Budiningsih S, Tjarta A, Ueda M, Cipto H, Mukhtar A. Biology effective doses of ambient solar-UV radiation in Indonesia and Japan. Med J Indones, 9:123-128, 2000 180. Tanaka K, Ootsuyama A, Tanooka H, Ansell JD. Test for fused-cell origin of tumors with Mus caroli carrying glucose-6-phosphate dehydrogenase cellular mosaicism. Oncol Rep, 7:897-898, 2000 14. Carcinogenesis Division 181. Ushijima T, Yamamoto M, Suzui M, Kuramoto T, Yoshida Y, Nomoto T, Tatematsu M, Sugimura T, Nagao M. Chromosomal mapping of genes controlling development, histological grade, depth of invasion, and size of rat stomach carcinomas. Cancer Res, 60:1092-1096, 2000 182. Yamashita S, Yoshida Y, Kurahashi A, Sugimura T, Ushijima T. Construction of a high-throughput rat genetic mapping system with 466 arbitrarily primed-representational difference analysis markers. Mamm Genome, 11:982-988, 2000 183. Higo K, Ushijima T, Oyabu A, Chunlin Y, Yagyu S, Takahashi H, Matsuyama M. Generation of a polymorphic marker linked to thymoma susceptibility gene of rat 1 by genetically-directed representational difference analysis. Exp Anim, 49:189-195, 2000 184. Manenti G, Nomoto T, De Gregorio L, Gariboldi M, Stefania FF, Nagao M, Dragani TA. Predisposition to lung tumorigenesis. Toxicol Lett, 112-113:257-263,2000 185. Dragani TA, Hirohashi S, Juji T, Kawajiri K, Kihara M, Ono-Kihara M, Manenti G, Nomoto T, Sugimura H, Genka K, Yokota J, Takahashi T, Mitsudomi T, Nagao M. Population-based mapping of pulmonary adenoma susceptibility 1 locus. Cancer Res, 60:5017-5020, 2000 186. Stuart GR, Thorleifson E, Okochi E, de Boer JG, Ushijima T, Nagao M, Glickman BW. Interpretation of mutational spectra from different genes: analyses of PhIP-induced mutational specificity in the lacI and cII transgenes from colon of Big Blue(R) rats. Mutat Res, 452:101-121, 2000 187. Takahashi S, Ikeda Y, Kimoto N, Okochi E, Cui L, Nagao M, Ushijima T, Shirai T. Mutation induction by mechanical irritation caused by uracil-induced urolithiasis in Big Blue(R) rats. Mutat Res, 447:275-280, 2000 188. Sugimura T, Ushijima T. Genetic and epigenetic alterations in carcinogenesis. Mutat Res, 462:235-246, 2000 189. Takai D, Yagi Y, Habib N, Sugimura T, Ushijima T. Hypomethylation of LINE1 retrotransposon in human hepatocellular carcinomas, but not in surrounding liver cirrhosis. Jpn J Clin Oncol, 30:306-309, 2000 190. Ashida A, Fukutomi T, Tsuda H, Akashi-Tanaka S, Ushijima T. Atypical medullary carcinoma of the breast with cartilaginous metaplasia in a patient with a BRCA1 germline mutation. Jpn J Clin Oncol, 30:30-32, 2000 191. Honda H, Ushijima T, Wakazono K, Oda H, Tanaka Y, Aizawa S, Ishikawa T, Yazaki Y, Hirai H. Acquired loss of p53 induces blastic transformation in p210bcr/abl-expressing hematopoietic cells: a transgenic study for blast crisis of human CML. Blood, 95:1144-1150, 2000 15. Section for Studies on Metastasis 192. Yamamoto H, Ochiya T, Takahama Y, Ishii Y, Osumi N, Sakamoto H, Terada M. Detection of spatial localization of Hst-1/Fgf-4 gene expression in brain and testis from adult mice. Oncogene, 19:3805-3810, 2000 17. Tumor Suppression and Functional Genomics Project 193. Murakami Y, Uejima H, Fukuhara H, Maruyama T, Oshimura M, Sekiya T. Construction of human-rodent hybrid cells containing single transferable fragments of human chromosome 10p. J Hum Genet, 45:370-373, 2000 194. Kanamori M, Kon H, Nobukuni T, Nomura S, Sugano K, Mashiyama S, Kumabe T, Yoshimoto T, Meuth M, Sekiya T, Murakami Y. Microsatellite instability and the PTEN1 gene mutation in a subset of early onset gliomas carrying germline mutation or promoter methylation of the hMLH1 gene. Oncogene, 19:1564-1571, 2000 195. Kuchiki H, Saino M, Nobukuni T, Yasuda J, Maruyama T, Kayama T, Murakami Y, Sekiya T. Detection of amplification of a chromosomal fragment at 6p21 including the cyclin D3 gene in a glioblastoma cell line by arbitrarily primed polymerase chain reaction. Int J Cancer, 85:113-116, 2000 19. Pathology Division, East 196. Emura M, Arndt W, Ochiai A, Kamino K, Horino M, Hirohashi S. Development of myofibroblasts from human bone marrow mesenchymal stem cells cocultured with human colon carcinoma cells and TGF beta 1. In Vitro Cell Dev Biol Anim, 36:77-80, 2000 197. Hasebe T, Mukai K, Tsuda H, Ochiai A. New prognostic histological parameter of invasive ductal carcinoma of the breast: clinicopathological significance of fibrotic focus. Pathol Int, 50:263-272, 2000 198. Hasebe T, Sasaki S, Imoto S, Ochiai A. Proliferative activity of intratumoral fibroblasts is closely correlated with lymph node and distant organ metastases of invasive ductal carcinoma of the breast. Am J Pathol, 156:1701-1710, 2000 199. Hasebe T, Morihiro M, Sasaki S, Shimoda T, Sugitoh M, Moriya Y, Ono M, Arai T, Ochiai A. Tumor thickness is a histopathologic predictive parameter of tumor metastasis and prognosis in patients with Dukes Stage C ulcerative-type colorectal carcinoma: a two-hospital-based study. Cancer, 89:35-45, 2000 200. Yokose T, Ito Y, Ochiai A. High prevalence of atypical adenomatous hyperplasia of the lung in autopsy specimens from elderly patients with malignant neoplasms. Lung Cancer, 29:125-130, 2000 201. Hosomi Y, Yokose T, Hirose Y, Nakajima R, Nagai K, Nishiwaki Y, Ochiai A. Increased cyclooxygenase 2 (COX- 2) expression occurs frequently in precursor lesions of human adenocarcinoma of the lung. Lung Cancer, 30:73-81, 2000 202. Yokose T, Suzuki K, Nagai K, Nishiwaki Y, Sasaki S, Ochiai A. Favorable and unfavorable morphological prognostic factors in peripheral adenocarcinoma of the lung 3 cm or less in diameter. Lung Cancer, 29:179-188, 2000 203. Suzuki K, Yokose T, Yoshida J, Nishimura M, Takahashi K, Nagai K, Nishiwaki Y. Prognostic significance of the size of central fibrosis in peripheral adenocarcinoma of the lung. Ann Thorac Surg, 69:893-897, 2000 204. Kamijo T, Yokose T, Hasebe T, Yonou H, Sasaki S, Hayashi R, Ebihara S, Miyahara H, Hosoi H, Ochiai A. Potential role of microvessel density in predicting radiosensitivity of T1 and T2 stage laryngeal squamous cell carcinoma treated with radiotherapy. Clin Cancer Res, 6:3159-3165, 2000 205. Moriyama E, Yokose T, Kodama T, Matsuno Y, Hojo F, Takahashi K, Nagai K, Nishiwaki Y, Ochiai A. Low-grade B-cell lymphoma of mucosa-associated lymphoid tissue in the thymus of a patient with pulmonary amyloid nodules. Jpn J Clin Oncol, 30:349-353, 2000 206. Yoshida J, Nagai K, Nishimura M, Takahashi K, Kakinuma R, Nishiwaki Y, Yokose T. Secretion of hCG/b-hCG by squamous cell carcinoma of the lung in a 31-year-old female smoker. Jpn J Clin Oncol, 30:163-166, 2000 207. Harada M, Yoshida J, Yokose T, Nishiwaki Y, Nagai K. Surgical management of primary lung cancer in an elderly patient with preoperative empyema. Jpn J Clin Oncol, 29:571-575, 1999 208. Yoshikawa T, Yoshida J, Nishimura M, Yokose T, Nishiwaki Y, Nagai K. Lung cancer implantation in the chest wall following percutaneous fine needle aspiration biopsy. Jpn J Clin Oncol, 30:450-452, 2000 209. Izuishi K, Ryu M, Hasebe T, Kinoshita T, Konishi M, Inoue K. Spontaneous total necrosis of hepatocellular carcinoma:report of a case. Hepatogastroenterology, 47:1122-1124, 2000 210. Watanabe H, Mai M, Shimoda T, Tatematsu M, Ochiai A, Mori M, Sano T, Aiko T, Yoshida S, Furukawa H, Kaminishi M, Koike M. Meeting report of the 72nd Japanese gastric cancer congress. Gastric Cancer, 3:1-8, 2000 211. Furuse J, Maru Y, Yoshino M, Mera K, Sumi H, Sekiguchi R, Satake M, Hasebe T, Ochiai A. Assessment of arterial tumor vascularity in small hepatocellular carcinoma: comparison between color Doppler ultrasonography and radiographic imagings with contrast medium: dynamic CT, angiography, and CT hepatic arteriography. Eur J Radiol, 36:20-27, 2000 20. Epidemiology and Biostatistics Division 212. Takahashi Y, Noda M, Tsugane S, Kuzuya T, Ito C, Kadowaki T. 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