List of Papers Published in 2001
1. Pathology Division 1. Tokunou M, Niki T, Eguchi K, Iba S, Tsuda H, Yamada T, Matsuno Y, Kondo H, Saitoh Y, Imamura H, Hirohashi S. c-MET expression in myofibroblasts: role in autocrine activation and prognostic significance in lung adenocarcinoma. Am J Pathol, 158:1451-1463, 2001 2. Yamamoto Y, Sakamoto M, Fujii G, Kanetaka K, Asaka M, Hirohashi S. Cloning and characterization of a novel gene, DRH1, down-regulated in advanced human hepatocellular carcinoma. Clin Cancer Res, 7:297-303, 2001 3. Kanetaka K, Sakamoto M, Yamamoto Y, Yamasaki S, Lanza F, Kanematsu T, Hirohashi S. Overexpression of tetraspanin CO-029 in hepatocellular carcinoma. J Hepatol, 35:637-642, 2001 4. Niki T, Iba S, Yamada T, Matsuno Y, Enholm B, Hirohashi S. Expression of vascular endothelial growth factor receptor 3 in blood and lymphatic vessels of lung adenocarcinoma. J Pathol, 193:450-457, 2001 5. Tsuda H, Takarabe T, Akashi-Tanaka S, Fukutomi T, Hirohashi S. Pattern of chromosome 16q loss differs between an atypical proliferative lesion and an intraductal or invasive ductal carcinoma occurring subsequently in the same area of the breast. Mod Pathol, 14:382-388, 2001 6. Saito Y, Kanai Y, Sakamoto M, Saito H, Ishii H, Hirohashi S. Expression of mRNA for DNA methyltransferases and methyl-CpG-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis. Hepatology, 33:561-568, 2001 7. Kanai Y, Ushijima S, Kondo Y, Nakanishi Y, Hirohashi S. DNA methyltransferase expression and DNA methylation of CpG islands and peri-centromeric satellite regions in human colorectal and stomach cancers. Int J Cancer, 91:205-212, 2001 8. Kanai Y, Ushijima S, Saito Y, Nakanishi Y, Sakamoto M, Hirohashi S. mRNA expression of genes altered by 5-azacytidine treatment in cancer cell lines is associated with clinicopathological parameters of human cancers. J Cancer Res Clin Oncol, 127:697-706, 2001 9. Naishiro Y, Yamada T, Takaoka AS, Hayashi R, Hasegawa F, Imai K, Hirohashi S. Restoration of epithelial cell polarity in a colorectal cancer cell line by suppression of b-catenin/T-cell factor 4-mediated gene transactivation. Cancer Res, 61:2751-2758, 2001 10. Takamura M, Sakamoto M, Genda T, Ichida T, Asakura H, Hirohashi S. Inhibition of intrahepatic metastasis of human hepatocellular carcinoma by Rho-associated protein kinase inhibitor Y-27632. Hepatology, 33:577-581, 2001 11. Sakamoto M, Takamura M, Ino Y, Miura A, Genda T, Hirohashi S. Involvement of c-Src in carcinoma cell motility and metastasis. Jpn J Cancer Res, 92:941-946, 2001 12. Fukushima N, Sakamoto M, Hirohashi S. Expression of laminin-5-g-2 chain in intraductal papillary-mucinous and invasive ductal tumors of the pancreas. Mod Pathol, 14:404-409, 2001 13. Moriya Y, Niki T, Yamada T, Matsuno Y, Kondo H, Hirohashi S. Increased expression of laminin-5 and its prognostic significance in lung adenocarcinomas of small size. Cancer, 91:1129-1141, 2001 14. Fukushima N, Sakamoto M, Mukai K, Kanai Y, Shimada K, Kosuge T, Hirohashi S. Intraductal papillary components in invasive ductal carcinoma of the pancreas are associated with long-term survival of patients. Hum Pathol, 32:834-841, 2001 15. Akashi-Tanaka S, Fukutomi T, Miyakawa K, Nanasawa T, Matsuo K, Hasegawa T, Tsuda H. Contrast-enhanced computed tomography for diagnosing the intraductal component and small invasive foci of breast cancer. Breast Cancer, 8:10-15, 2001 16. Fukagawa T, Sasako M, Mann GB, Sano T, Katai H, Maruyama K, Nakanishi Y, Shimoda T. Immunohistochemically detected micrometastases of the lymph nodes in patients with gastric carcinoma. Cancer, 92:753-760, 2001 17. Fukushima N, Mukai K, Sakamoto M, Hasebe T, Shimada K, Kosuge T, Kinoshita T, Hirohashi S. Invasive carcinoma derived from intraductal papillary-mucinous carcinoma of the pancreas: clinicopathologic and immunohistochemical study of eight cases. Virchows Arch, 439:6-13, 2001 18. Hasegawa T, Hirose T, Ayala AG, Ito S, Tomaru U, Matsuno Y, Shimoda T, Hirohashi S. Adult neuroblastoma of the retroperitoneum and abdomen. Am J Surg Pathol, 25:918-924, 2001 19. Hasegawa T, Matsuno Y, Shimoda T, Umeda T, Yokoyama R, Hirohashi S. Proximal-type epithelioid sarcoma: a clinicopathologic study of 20 cases. Mod Pathol, 14:655-663, 2001 20. Hasegawa T, Yokoyama R, Matsuno Y, Shimoda T, Hirohashi S. Prognostic significance of histologic grade and nuclear expression of b-catenin in synovial sarcoma. Hum Pathol, 32:257-263, 2001 21. Hatanaka Y, Hashizume K, Kamihara Y, Itoh H, Tsuda H, Osamura RY, Tani Y. Quantitative immunohistochemical evaluation of HER2/neu expression with HercepTestTM in breast carcinoma by image analysis. Pathol Int, 51:33-36, 2001 22. Igaki H, Kato H, Tachimori Y, Sato H, Daiko H, Nakanishi Y. Prognostic evaluation for squamous cell carcinomas of the lower thoracic esophagus treated with three-field lymph node dissection. Eur J Cardio-thorac Surg, 19:887-893, 2001 23. Imamura M, Shimada Y, Ide H, Ozawa S, Kuwano H, Kato H, Yamana H, Shiozaki H, Kobayashi S, Sakamoto T, Nishihara T, Sasano H, Mukai M, Takubo K, Nakanishi Y, Isono K. Prognostic significance of CyclinD1 and E-Cadherin in patients with esophageal squamous cell carcinoma: multiinstitutional retrospective analysis. J Am Coll Surg, 192:708-718, 2001 24. Ishikawa M, Nakanishi Y, Yamazaki N, Yamamoto A. Malignant eccrine spiradenoma: a case report and review of the literature. Dermatol Surg, 27:67-70, 2001 25. Kasamatsu T, Hasegawa T, Tsuda H, Okada S, Sawada M, Yamada T, Tsunematsu R, Ohmi K, Mizuguchi K, Kawana T. Primary epithelioid sarcoma of the vulva. Int J Gynecol Cancer, 11:316-320, 2001 26. Kitamura H, Kobayashi T, Kaneko M, Kusumoto M, Kodama T, Matsuno Y, Niki T. Pulmonary amyloidosis diagnosed by CT-guided transbronchial biopsy: a case report. Jpn J Clin Oncol, 31:209-211, 2001 27. Kokawa A, Yamaguchi H, Tachimori Y, Kato H, Watanabe H, Nakanishi Y. Other primary cancers occurring after treatment of superficial oesophageal cancer. Br J Surg, 88:439-443, 2001 28. Matsuo K, Fukutomi T, Tsuda H, Akashi-Tanaka S, Shimizu C, Hasegawa T. Differences in estrogen receptor status, HER2, and p53 comparing metachronous bilateral breast carcinoma. J Surg Oncol, 77:31-34, 2001 29. Matsuo K, Fukutomi T, Tsuda H, Hasegawa T, Akashi-Tanaka S, Nanasawa T. A case of malignant phyllodes tumor of the breast with osteosarcomatous features. Breast Cancer, 8:79-83, 2001 30. Nakanishi Y, Ochiai A, Kato H, Tachimori Y, Igaki H, Hirohashi S. Clinicopathological significance of tumor nest configuration in patients with esophageal squamous cell carcinoma. Cancer, 91:1114-1120, 2001 31. Okusaka T, Okada S, Ueno H, Ikeda M, Shimada K, Yamamoto J, Kosuge T, Yamasaki S, Fukushima N, Sakamoto M. Abdominal pain in patients with resectable pancreatic cancer with reference to clinicopathologic findings. Pancreas, 22:279-284, 2001 32. Saito A, Shimoda T, Nakanishi Y, Ochiai A, Toda G. Histologic heterogeneity and mucin phenotypic expression in early gastric cancer. Pathol Int, 51:165-171, 2001 33. Sato H, Hasegawa T, Kanai Y, Tsutsumi Y, Osamura Y, Abe Y, Sakai H, Hirohashi S. Expression of cadherins and their undercoat proteins (a-, b-, and g-catenins and p120) and accumulation of b-catenin with no gene mutations in synovial sarcoma. Virchows Arch, 438:23-30, 2001 34. Tajima Y, Nakanishi Y, Yoshino T, Kokawa A, Kusano M, Shimoda T. Clinicopathological study of early adenocarcinoma of the gastric cardia: comparison with early adenocarcinoma of the distal stomach and esophagus. Oncology, 61:1-9, 2001 35. Tanaka M, Shibui S, Nomura K, Nakanishi Y. Radiotherapy combined with nimustine hydrochloride and etoposide for malignant gliomas: results of a pilot study. Jpn J Clin Oncol, 31:246-250, 2001 36. Tanaka S, Kobayashi T, Nakanishi K, Okubo M, Murase T, Hashimoto M, Watanabe G, Matsushita H, Endo Y, Yoshizaki H, Kosuge T, Sakamoto M, Takeuchi K. Evidence of primary b-cell destruction by T-cells and b-cell differentiation from pancreatic ductal cells in diabetes associated with active autoimmune chronic pancreatitis. Diabetes Care, 24:1661-1667, 2001 37. Terasaki H, Niki T, Hasegawa T, Yamada T, Suzuki K, Kusumoto M, Fujimoto K, Hayabuchi N, Matsuno Y, Shimoda T. Primary synovial sarcoma of the lung: a case report confirmed by molecular detection of SYT-SSX fusion gene transcripts. Jpn J Clin Oncol, 31:212-216, 2001 38. Tsuda H, Tani Y, Hasegawa T, Fukutomi T. Concordance in judgments among c-erbB-2 (HER2/neu) overexpression detected by two immunohistochemical tests and gene amplification detected by Southern blot hybridization in breast carcinoma. Pathol Int, 51:26-32, 2001 39. Okada K, Hasegawa T, Yokoyama R. Rosette-forming epithelioid osteosarcoma: a histologic subtype with highly aggressive clinical behavior. Hum Pathol, 32:726-733, 2001 40. Kubo M, Fukutomi T, Akashi-Tanaka S, Hasegawa T. Association of breast cancer with meningioma: report of a case and review of the literature. Jpn J Clin Oncol, 31:510-513, 2001 41. Takahashi T, Akashi-Tanaka S, Fukutomi T, Watanabe T, Katsumata N, Miyakawa K, Hasegawa T, Tsuda H. Two special types of breast cancer presenting as progressive disease after neoadjuvant chemotherapy with docetaxel plus doxorubicin. Breast Cancer, 8:234-237, 2001 42. Yajima S, Fukutomi T, Akashi-Tanaka S, Nanasawa T, Miyakawa K, Hasegawa T. Diabetic mastopathy: a case report with reference to the findings of enhanced computed tomography. Breast Cancer, 8:246-249, 2001 43. Takarabe T, Tsuda H, Okada S, Fukutomi T, Hirohashi S. Detection of numerical alterations of chromosome 1 in cytopathological specimens of breast tumors by chromogen in situ hybridization. Pathol Int, 51:786-791, 2001 44. Tajima Y, Shimoda T, Nakanishi Y, Yokoyama N, Tanaka T, Shimizu K, Saito T, Kawamura M, Kusano M, Kumagai K. Gastric and intestinal phenotypic marker expression in gastric carcinomas and its prognostic significance: immunohistochemical analysis of 136 lesions. Oncology, 61:212-220, 2001 45. Kubota K, Kato H, Tachimori Y, Watanabe H, Yamaguchi H, Nakanishi Y, Iinuma G. Surgical therapy for recurrent esophageal cancers at anastomoses after esophagectomy. Hepatogastroenterology, 48:1364-1367, 2001 46. Tsuda H, Akiyama F, Terasaki H, Hasegawa T, Kurosumi M, Shimadzu M, Yamamori S, Sakamoto G. Detection of HER-2/neu (c-erb B-2) DNA amplification in primary breast carcinoma. Cancer, 92:2965-2974, 2001 47. Umemura S, Sakamoto G, Sasano H, Tsuda H, Akiyama F, Kurosumi M, Tokuda Y, Watanabe T, Toi M, Hasegawa T, Osamura Y. Evaluation of HER2 status: for the treatment of metastatic breast cancers by humanized anti-HER2 monoclonal antibody (trastuzumab) (pathological commitee for optimal use of trastuzumab). Breast Cancer, 8:316-320, 2001 2. Biochemistry Division 48. Ochiai M, Ubagai T, Kawamori T, Imai H, Sugimura T, Nakagama H. High susceptibility of Scid mice to colon carcinogenesis induced by azoxymethane indicates a possible caretaker role for DNA-dependent protein kinase. Carcinogenesis, 22:1551-1555, 2001 49. Burnouf DY, Miturski R, Nagao M, Nakagama H, Nothisen M, Wagner J, Fuchs RPP. Early detection of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine(PhIP)-induced mutations within the Apc gene of rat colon. Carcinogenesis, 22:329-335, 2001 50. Nagao M, Ochiai M, Okochi E, Ushijima T, Sugimura T. LacI transgenic animal study: relationships among DNA-adduct levels, mutant frequencies and cancer incidences. Mutat Res, 477:119-124, 2001 51. Fukuda H, Sugimura T, Nagao M, Nakagama H. Detection and isolation of minisatellite Pc-1 binding proteins. Biochim Biophys Acta, 1528:152-158, 2001 52. Minemoto Y, Gannon J, Masutani M, Nakagama H, Sasagawa T, Inoue M, Masamune Y, Yamashita K. Characterization of adriamycin-induced G2 arrest and its abrogation by caffeine in FL-amnion cells with or without p53. Exp Cell Res, 262:37-48, 2001 53. Tsutsumi M, Masutani M, Nozaki T, Kusuoka O, Tsujiuchi T, Nakagama H, Suzuki H, Konishi Y, Sugimura T. Increased susceptibility of poly(ADP-ribose) polymerase-1 knockout mice to nitrosamine carcinogenicity. Carcinogenesis, 22:1-3, 2001 54. Nozaki T, Fujihara H, Kamada N, Ueda O, Takato T, Nakagama H, Sugimura T, Suzuki H, Masutani M. Hyperploidy of embryonic fibroblasts derived from Parp-1 knockout mouse. Proc Jpn Acad, 77:121-124, 2001 55. Masutani M, Nozaki T, Watanabe M, Ochiya T, Hasegawa F, Nakagama H, Suzuki H, Sugimura T. Involvement of poly(ADP-ribose) polymerase in trophoblastic cell differentiation during tumorigenesis. Mutat Res, 477:111-117, 2001 3. Experimental Pathology and Chemotherapy Division 56. Tsuda H, Asamoto M, Ochiya T, Toriyama-Baba H, Naito A, Ota T, Sekiya T, Terada M. High susceptibility of transgenic rats carrying the human c-Ha-ras proto-oncogene to chemically-induced mammary carcinogenesis. Mut Res, 477:173-182, 2001 57. Fukamachi K, Matsuoka Y, Kitanaka C, Kuchino Y, Tsuda H. Rat neuronal leucinerich repeat protein-3: cloning and regulation of the gene expression. Biochem Biophys Res Commun, 287:257-263, 2001 58. Tsuda H, Sekine K. Milk components as cancer chemopreventive agents. Asian Pacific J Cancer Prev, 1:277-282, 2000 59. Tsuda H, Sekine K, Takasuka N, Toriyama-Baba H, Iigo M. Prevention of colon carcinogenesis and carcinoma metastasis by orally administered bovine lactoferrin in animals. BioFactors, 12:83-88, 2000 60. Kuhara T, Iigo M, Itoh T, Ushida Y, Sekine K, Terada N, Okamura H, Tsuda H. Orally administered lactoferrin exerts an antimetastatic effect and enhances production of IL-18 in the intestinal epithelium. Nutr Cancer, 38:192-199, 2000 61. Han BS, Park CB, Takasuka N, Naito A, Sekine K, Nomura E, Taniguchi H, Tsuno T, Tsuda H. A ferulic acid derivative, ethyl 3-(4'-geranyloxy-3-methoxyphenyl)-2-propenoate, as a new candidate chemopreventive agent for colon carcinogenesis in the rat. Jpn J Cancer Res, 92:404-409, 2001 62. Toriyama-Baba H, Iigo M, Asamoto M, Iwahori Y, Park CB, Han BS, Takasuka N, Kakizoe T, Ishikawa C, Yazawa K, Araki E, Tsuda H. Organotropic chemopreventive effects of n-3unsaturated fatty acids in a rat multi-organ carcinogenesis model. Jpn J Cancer Res, 92:1175-1183, 2001 63. Kim DJ, Takasuka N, Nishino H, Tsuda H. Chemoprevention of lung cancer by lycopene. BioFactors, 13:95-102, 2000 64. Park CB, Kim DJ, Moore MA, Takasuka N, Tsuda H. Promotion of liver lesion development in the Syrian hamster by dietary fat following multi-organ initiation is inhibited by DHEA-S administration. Asian Pacific J Cancer Prev, 1:329-332, 2000 65. Goldberg GS, Jin Z, Ichikawa H, Naito A, Ohki M, El-Deiry WS, Tsuda H. Global effects of anchorage on gene expression during mammary carcinoma cell growth reveal role of tumor necrosis factor-related apoptosis-inducing ligand in anoikis. Cancer Res, 61:1334-1337, 2001 66. Tokuzen R, Iwahori Y, Asamoto M, Iigo M, Hasegawa F, Satoh T, Ishidate MJ, Tsuda H. Establishment and characterization of three new rat renal cell carcinoma cell lines from N-ethyl-N-hydroxyethylnitrosamine-induced basophilic cell tumors. Pathol Int, 51:65-71, 2001 4. Biology Division 67. Nishioka M, Kohno T, Takahashi M, Niki T, Yamada T, Sone S, Yokota J. Identification of a 428-kb homozygously deleted region disrupting the SEZ6L gene at 22q12.1 in a lung cancer cell line. Oncogene, 19:6251-6260, 2000 68. Yanaihara N, Kohno T, Takakura S, Takei K, Otsuka A, Sunaga N, Takahashi M, Yamazaki M, Tashiro H, Fukuzumi Y, Fujimori Y, Hagiwara K, Tanaka T, Yokota J. Physical and transcriptional map of a 311-kb segment of chromosome 18q21, a candidate lung tumor suppressor locus. Genomics, 72:169-179, 2001 69. Sunaga N, Kohno T, Kolligs FT, Fearon ER, Saito R, Yokota J. Constitutive activation of the Wnt signaling pathway by CTNNBI(b-catenin) mutations in a subset of human lung adenocarcinoma. Genes Chromosom Cancer, 30:316-321, 2001 70. Takakura S, Kohno T, Manda R, Okamoto A, Tanaka T, Yokota J. Genetic alterations and expression of the protein phosphatase 1 genes in human cancers. Int J Oncol, 18:817-824, 2001 71. Shinozaki H, Okamoto A, Shimizu K, Saito M, Yokota J, Ochiai K. Absence of p51 alterations in human ovarian cancer. Int J Oncol, 18:549-552, 2001 72. Kondo M, Ji L, Kamibayashi C, Tomizawa Y, Randle D, Sekido Y, Yokota J, Kashuba V, Zabarovsky E, Kuzumin I, Lerman M, Roth J, Minna JD. Overexpression of candidate tumor suppressor gene FUS1 isolated from the 3p21.3 homozygous deletion region leads to G1 arrest and growth inhibition of lung cancer cells. Oncogene, 20:6258-6262, 2001 73. Tomizawa Y, Sekido Y, Kondo M, Gao B, Yokota J, Roche J, Drabkin H, Leman MI, Gazdar AF, Minna JD. Inhibition of lung cancer cell growth and induction of apoptosis after reexpression of 3p21.3 candidate tumor suppressor gene SEMA3B. Proc Natl Acad Sci USA, 98:13954-13959, 2001 74. Nagashima M, Shiseki M, Miura K, Hagiwara K, Linke SP, Pedeux R, Wang XW, Yokota J, Riabowol K, Harris CC. DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53. PNAS, 98:9671-9676, 2001 75. Ookawa K, Tsuchida S, Kohno T, Yokota J. Alterations in expression of E2F-1 and E2F-responsive genes by RB, p53 and p21Sdi1/WAF1/Cip1 expression. Febs Lett, 500:25-30, 2001 76. Shindo-Okada N, Takeuchi K, Nagamachi Y. Establishment of cell lines with high- and low-metastatic potential from PC-14 human lung adenocarcinoma. Jpn J Cancer Res, 92:174-183, 2001 77. Shindo-Okada N, Shimizu K. Isolation of a novel actin-related gene expressed in low-metastatic PC-14 human lung adenocarcinoma. Biochem Biophys Res Commun, 280:61-67, 2001 78. Shinmura K, Yokota J. The OGG1 gene encodes a repair enzyme for oxidatively damaged DNA and is involved in human carcinogenesis. Antioxid Redox Signal, 3:597-609, 2001 79. Shinmura K, Yamaguchi S, Saitoh T, Kohno T, Yokota J. Somatic mutations and single nucleotide polymorphisms of base excision repair genes involved in the repair of 8-hydroxyguanine in damaged DNA. Cancer Lett, 166:65-69, 2001 80. Sunaga N, Kohno T, Shinmura K, Saitoh T, Matsuda T, Saito R, Yokota J. OGG1 protein suppresses G:CT:A mutation in a shuttle vector containing 8-hydroxyguanine in human cells. Carcinogenesis, 22:1355-1362, 2001 81. Saitoh T, Shinmura K, Yamaguchi S, Tani M, Seki S, Murakami H, Nojima Y, Yokota J. Enhancement of OGG1 protein AP lyase activity by increase of APEX protein. Mutat Res, 486:31-40, 2001 82. Kimura K, Shinmura K, Hasegawa T, Beppu Y, Yokoyama R, Yokota J. Germline p53 mutation in a patient with multiple primary cancers. Jpn J Clin Oncol, 31:349-351, 2001 5. Pharmacology Division 83. Asada-Mikami R, Heike Y, Kanai S, Azuma M, Shirakawa K, Takaue Y, Krasnykh V, Curiel DT, Terada M, Abe T, Wakasugi H. Efficient gene transduction by RGD-fiber modified recombinant adenovirus into dendritic cells. Jpn J Cancer Res, 92:321-327, 2001 84. Inoue Y, Takaue Y, Takei M, Kato K, Kanai S, Harada Y, Tobisu K, Noguchi M, Kakizoe T, Itoh K, Wakasugi H. Induction of tumor specific cytotoxic T lymphocytes in prostate cancer using prostatic acid phosphatase derived HLA-A2402 binding peptide. J Urol, 166:1508-1513, 2001 85. Kato K, Takaue Y, Wakasugi H. T-cell-conditioned medium efficiently induces the maturation and function of human dendritic cells. J Leukoc Biol, 70:941-949, 2001 86. Niiya H, Kanda Y, Saito T, Ohnishi T, Kanai S, Kawano Y, Kamijo K, Iizuka A, Yakushijin K, Ueda K, Chizuka A, Iijima K, Ohnishi M, Nakai K, Makimoto A, Tanosaki R, Tobinai K, Wakasugi H, Takaue Y, Mineishi S. Early full donor myeloid chimerism after reduced-intensity stem cell transplantation using a combination of fludarabine and busulfan. Haematologica, 86:1071-1074, 2001 87. Ikarashi Y, Mikami R, Bendelac A, Terme M, Chaput N, Terada M, Tursz T, Angevin E, Lemonnier FA, Wakasugi H, Zitvogel L. Dendritic cell maturation overrules H-2D-mediated natural killer T (NKT) cell inhibition: critical role for B7 in CD1d-dependent NKT cell interferon g production. J Exp Med, 194:1179-1186, 2001 88. Noda N, Ochiai A, Miyazaki K, Sugimura T, Terada M, Wakasugi H. Detection of thioredoxin in gastric cancer: association with histological type. Antioxid Redox Signal, 2:519-528, 2000 89. Noda N, Wakasugi H. Cancer and oxidative stress. JMAJ, 44:535-539, 2001 90. Shirakawa K, Tsuda H, Heike Y, Kato K, Asada R, Inomata M, Sasaki H, Kasumi F, Yoshimoto M, Iwanaga T, Konishi F, Terada M, Wakasugi H. Absence of endothelial cells, central necrosis, and fibrosis are associated with aggressive inflammatory breast cancer. Cancer Res, 61:445-451, 2001 91. Kanzawa F, Koizumi F, Koh Y, Nakamura T, Tatsumi Y, Fukumoto H, Saijo N, Yoshioka T, Nishio K. In vitro synergistic interactions between the cisplatin analogue nedaplatin and the DNA topoisomerase I inhibitor irinotecan and the mechanism of this interaction. Clin Cancer Res, 7:202-209, 2001 92. Natsume T, Nakamura T, Koh Y, Kobayashi M, Saijo N, Nishio K. Gene expression profiling of exposure to TZT-1027, a novel microtubule-interfering agent, in non-small cell lung cancer PC-14 cells and astrocytes. Invest New Drugs, 19:293-302, 2001 93. Tatsumi Y, Arioka H, Ikeda S, Fukumoto H, Miyamoto K, Fukuoka K, Ohe Y, Saijo N, Nishio K. Enhancement of in vivo antitumor activity of a novel antimitotic 1-phenylpropenone derivative, AM-132, by tumor necrosis factor-a or interleukin-6. Jpn J Cancer Res, 92:768-777, 2001 94. Fukuoka K, Arioka H, Iwamoto Y, Fukumoto H, Kurokawa H, Ishida T, Tomonari A, Suzuki T, Usuda J, Kanazawa F, Saijo N, Nishio K. Mechanism of the radiosensitization induced by vinorelbine in human non-small cell lung cancer cells. Lung Cancer, 34:451-460, 2001 95. Shimizu M, Tamura T, Yamada Y, Akiyama Y, Saijo N, Nishio K. CPT-11 alters the circadian rhythm of dihydropyrimidine dehydrogenase mRNA in mouse liver. Jpn J Cancer Res, 92:554-561, 2001 96. Saijo N, Tamura T, Yamamoto N, Nishio K. New strategies for cancer therapy in the 21st century. Cancer Chemother Pharmacol, 48:s102-s106, 2001 97. Usuda J, Okunaka T, Furukawa K, Tsuchida T, Kuroiwa Y, Ohe Y, Saijo N, Nishio K, Konaka C, Kato H. Increased cytotoxic effects of photodynamic therapy in IL-6 gene transfected cells via enhanced apoptosis. Int J Cancer, 93:475-480, 2001 98. Yoshida M, Feng W, Nishio K, Takahashi M, Heike Y, Saijo N, Wakasugi H, Ikekawa T. Antitumor action of the PKC activator gnidimacrin through CDK2 inhibition. Int J Cancer, 94:348-352, 2001 99. Nishio K, Nakamura T, Koh Y, Kanzawa F, Tamura T, Saijo N. Oncoprotein 18 overexpression increases the sensitivity to vindesine in the human lung carcinoma cells. Cancer, 91:1494-1499, 2001 100. Zhang J, Takahashi K, Takahashi F, Shimizu K, Ohshita F, Kameda Y, Maeda K, Nishio K, Fukuchi Y. Differential osteopontin expression in lung cancer. Cancer Lett, 171:215-222, 2001 101. Tsunoda T, Nakamura T, Ishimoto K, Yamaue H, Tanimura H, Saijo N, Nishio K. Upregulated expression of angiogenesis genes and down regulation of cell cycle genes in human colorectal cancer tissue determined by cDNA macroarray. Anticancer Res, 21:137-144, 2001 102. Nakamura T, Koizumi F, Kaneko N, Tamura T, Chiwaki F, Koh Y, Akutagawa S, Saijo N, Nishio K. Reversal of cisplatin resistance by the 1,4-benzothiazepine derivative, JTV-519. Jpn J Cancer Res, 92:597-602, 2001 6. Biophysics Division 103. Noguchi K, Kokubu A, Kitanaka C, Ichijo H, Kuchino Y. ASK1-signaling promotes c-Myc protein stability during apoptosis. Biochem Biophys Res Commun, 281:1313-1320, 2001 104. Liang A, Bruen-Nieweler C, Muramatsu T, Kuchino Y, Beier H, Heckmann K. The ciliate Euplotes octocarinatus expresses two polypeptide release factors of the type eRF1. Gene, 262:161-168, 2001 105. Muramatsu T, Heckmann K, Kitanaka C, Kuchino Y. Molecular mechanism of stop codon recognition by eRF1: a wobble hypothesis for peptide anticodons. FEBS Lett, 488:105-109, 2001 7. Growth Factor Division 106. Tsukada T, Yamaguchi K, Kameya T. The MEN1 gene and associated diseases: an update. Endocr Pathol, 12:259-273, 2001 107. Wada S, Watanabe M, Tsukada T, Yasuda S, Yamaguchi K, Kitahama S, Iitaka M, Katayama S. A germline mutation, 1001delC, of the multiple endocrine neoplasia type1 (MEN 1) gene in a Japanese family. Intern Med, 40:499-505, 2001 108. Nakao A, Naomoto Y, Kataoka M, Haisa M, Kataoka K, Saitoh S, Fujiwara T, Yamatsuji T, Shigemitsu K, Umeoka T, Isozaki H, Futami H, Yamaguchi K, Tanaka N. A family of multiple endocrine neoplasia type 2A with the RET proto-oncogene mutation in codon 618 (CysArg). Jpn J Clin Oncol, 31:157-161, 2001 109. Ohkura N, Kishi M, Tsukada T, Yamaguchi K. Menin, a gene product responsible for multiple endocrine neoplasia type 1, interacts with the putative tumor metastasis suppressor nm23. Biochem Biophys Res Commun, 282:1206-1210, 2001 110. Hosono T, Ohkura N, Tsukada T, Maruyama K, Yamaguchi K. Regulation of the NGFI-B family gene expression by steroid and related hormones in MCF-7 breast cancer cells. Biomed Res, 21:263-268, 2000 111. Ohkura N, Ohkubo T, Maruyama K, Tsukada T, Yamaguchi K. The orphan nuclear receptor NOR-1 interacts with the homeobox containing protein Six3. Dev Neurosci, 23:17-24, 2001 112. Akiyama Y, Watanabe M, Maruyama K, Ruscetti FW, Wiltrout RH, Yamaguchi K. Enhancement of antitumor immunity against B16 melanoma tumor using genetically modified dendritic cells to produce cytokines. Gene Ther, 7:2113-2121, 2000 113. Maruyama K, Akiyama Y, Nara-Ashizawa N, Hojo T, Cheng J-Y, Mizuguchi H, Hayakawa T, Yamaguchi K. 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Curr Gene Ther, 1:31-52, 2001 210. Honma K, Ochiya T, Nagahara S, Sano A, Yamamoto H, Hirai K, Aso Y, Terada M. Atelocollagen-based gene transfer in cells allows high-throughput screening of gene functions. Biochem Biophys Res Commun, 289:1075-1081, 2001 16. Section for Studies on Host-Immune Response 211. Aoki K, Furuhata S, Hatanaka K, Maeda M, Remy J-S, Behr J-P, Terada M, Yoshida T. Polyethylenimine-mediated gene transfer into pancreatic tumor dissemination in the murine peritoneal cavity. Gene Therapy, 8:508-514, 2001 17. Tumor Suppression and Functional Genomics Project 212. Kuramochi M, Fukuhara H, Nobukuni T, Kanbe T, Maruyama T, Ghosh HP, Pletcher M, Isomura M, Onizuka M, Kitamura T, Sekiya T, Reeves RH, Murakami Y. TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer. Nat Genet, 27:427-430, 2001 213. Fukuhara H, Kuramochi M, Nobukuni T, Fukami T, Saino M, Maruyama T, Nomura S, Sekiya T, Murakami Y. Isolation of the TSLL1 and TSLL2 genes, members of the tumor suppressor TSLC1 gene family encoding transmembrane proteins. Oncogene, 20:5401-5407, 2001 214. Fukuhara H, Maruyama T, Nomura S, Oshimura M, Kitamura T, Sekiya T, Murakami Y. Functional evidence for the presence of tumor suppressor gene on chromosome 10p15 in human prostate cancers. Oncogene, 20:314-319, 2001 215. Nishimoto A, Miura N, Horikawa I, Kugoh H, Murakami Y, Hirohashi S, Kawasaki H, Gazdar AF, Shay JW, Barrett CJ, Oshimura M. Functional evidence for a telomerase repressor gene on human chromosome 10p15.1. Oncogene, 20:828-835, 2001 216. Kanbe T, Nobukuni T, Kawasaki H, Sekiya T, Murakami Y. Four single-nucleotide polymorphisms in the BUB1 gene. J Hum Genet, 46:150-151, 2001 18. DNA Methylation and Genome Function Project 217. Shiraishi M, Lerman LS, Oates AJ, Li X, Chuu YH, Sekiguchi A, Sekiya T. Segregation of partly melted molecules and its application to the isolation of methylated CpG islands in human cancer cells. Gene Ther Mol Biol, 5:39-46, 2000 19. Chromatin Function in Leukemogenesis Project 218. Yokoyama A, Kawaguchi Y, Kitabayashi I, Ohki M, Hirai K. The conserved domain CR2 of Epstein-Barr virus nuclear antigen leader protein is responsible not only for nuclear matrix association but also for nuclear localization. Virology, 279:401-413, 2001 219. Yokoyama A, Tanaka M, Matsuda G, Kato K, Kanamori M, Kawasaki H, Hirano H, Kitabayashi I, Ohki M, Hirai K, Kawaguchi Y. Identification of major phosphorylation sites of Epstein-Barr virus nuclear antigen leader protein (EBNA-LP): ability of EBNA-LP to induce latent membrane protein 1 cooperatively with EBNA-2 is regulated by phosphorylation. J Virol, 75:5119-5128, 2001 20. Pathology Division, East 220. Miyamoto S, Ochiai A, Boku N, Ohtsu A, Tahara M, Yoshida S, Okabe H, Takechi T, Fukushima M. Discrepancies between the gene expression, protein expression, and enzymatic activity of thymidylate synthase and dihydropyrimidine dehydrogenase in human gastrointestinal cancers and adjacent normal mucosa. Int J Oncol, 18: 705-713, 2001 221. Hasebe T, Sasaki S, Sugitoh M, Ono M, Saitoh N, Ochiai A. Highly proliferative intratumoral fibroblasts and a high proliferative microvessel index are significant predictors of tumor metastasis in T3 ulcerative-type colorectal cancer. Hum Pathol, 32:401-409, 2001 222. Hasebe T, Sasaki S, Imoto S, Ochiai A. Highly proliferative fibroblasts forming fibrotic focus govern metastasis of invasive ductal carcinoma of the breast. Mod Pathol, 14:325-337, 2001 223. Hironaka S, Boku N, Ohtsu A, Ochiai A, Yoshida S, Ejiri Y. Endoscopic mucosal resection for early adenocarcinoma arising in Barrett's esophagus. Dig Endosc, 13: 104-107, 2001 224. Yonou H, Yokose T, Kamijo T, Kanomata N, Hasebe T, Nagai K, Hatano T, Ogawa Y, Ochiai A. Establishment of a novel species- and tissue-specific metastasis model of human prostate cancer in humanized non-obese diabetic/severe combined immunodeficient mice engrafted with human adult lung and bone. Cancer Res, 61:2177-2182, 2001 225. Kamijo T, Yokose T, Hasebe T, Yonou H, Hayashi R, Ebihara S, Ochiai A. Image analysis of microvessel surface area predicts radiosensitivity in early-stage laryngeal carcinoma treated with radiotherapy. Clin Cancer Res, 7:2809-2814, 2001 226. Ito Y, Kamijo T, Yokose T, Kawashima M, Ogino T, Ikeda H, Hayashi R, Sasaki S, Ochiai A. Microvessel density predicts the radiosensitivity of metastatic head and neck squamous cell carcinoma in cervical lymph nodes. Int J Oncol, 19:1127-1132, 2001 227. Aoyagi Y, Yokose T, Minami Y, Ochiai A, Iijima T, Morishita Y, Oda T, Fukao K, Noguchi M. Accumulation of losses of heterozygosity and multistep carcinogenesis in pulmonary adenocarcinoma. Cancer Res, 61:7950-7954, 2001 228. Kawasaki H, Nagai K, Yokose T, Yoshida J, Nishimura M, Takahashi K, Suzuki K, Kakinuma R, Nishiwaki Y. Clinicopathological characteristics of surgically resected lung cancer associated with idiopathic pulmonary fibrosis. J Surg Oncol, 76:53-57, 2001 229. Ewis AA, Kondo K, Lee J, Tsuyuguchi M, Hashimoto M, Yokose T, Mukai K, Kodama T, Shinka T, Monden Y, Nakahori Y. Occupational cancer genetics: infrequent ras oncogenes point mutations in lung cancer samples from chromate workers. Am J Ind Med, 40:92-97, 2001 230. Yokose T, Doi M, Tanno K, Yamazaki K, Ochiai A. Atypical adenomatous hyperplasia of the lung in autopsy cases. Lung Cancer, 33:155-161, 2001 231. Nakahara R, Yokose T, Nishiwaki Y, Ochiai A. Atypical adenomatous hyperplasia of the lung: a clinicopathological study of 118 cases including cases with multiple atypical adenomatous hyperplasia. Thorax, 56:302-305, 2001 232. Shimoyama Y, Mukai M, Asato Y, Ochiai A. Clinical and endoscopic improvement of lymphocytic gastritis with eradication of Helicobacter pylori. Gastrointest Endosc, 54:251-254, 2001 233. Tanizaki H, Furuse J, Yoshino M, Ogino T, Ishikura S, Satake M, Hasebe T. Combination radiotherapy for hepatocellular carcinoma with intraductal tumor thrombus: a case report. Eur J Radiol, 38:213-218, 2001 234. Kawasaki H, Nagai K, Yokose T, Yoshida J, Ohmatsu H, Nishiwaki Y. A 7 mm lung adenocarcinoma with mediastinal involvement and lymphangiosis carcinomatosa: a case report. Jpn J Clin Oncol, 31:35-38, 2001 235. Takahashi S, Hasebe T, Oda T, Sasaki S, Kinoshita T, Konishi M, Ueda T, Ochiai T, Ochiai A. Extra-tumor perineural invasion predicts postoperative development of peritoneal dissemination in pancreatic ductal adenocarcinoma. Anticancer Res, 21:1407-1412, 2001 236. Goto K, Kodama T, Matsuno Y, Yokose T, Asamura H, Kamiya N, Shimosato Y. Clinicopathologic and D ytometric analysis of carcinoid tumors of the thymus. Mod Pathol, 14:985-994, 2001 237. Goto K, Yokose T, Kodama T, Nagai K, Nishiwaki Y, Ando M, Mukai K, Ochiai A. Detection of early invasion on the basis of basement membrane destruction in small adenocarcinomas of the lung and its clinical implications. Mod Pathol, 14:1237-1245, 2001 21. Epidemiology and Biostatistics Division 238. Tsugane S, Sobue T. Baseline survey of JPHC Study -design and participation rate. J Epidemiol, 11:s24-s29, 2001 239. Tsugane S, Sasaki S, Kobayashi M, Tsubono Y, Sobue T. Dietary habits among the JPHC Study participants at baseline survey. J Epidemiol, 11:s30-s43, 2001 240. Watanabe S, Tsugane S, Sobue T, Konishi M, Baba S. Study design and organization of the JPHC Study. J Epidemiol, 11:s3-s7, 2001 241. Baba S, Mannami T, Konishi M, Sasaki S. Anthropometric measures, blood pressure and major laboratory examination results in the health check-up examination among the JPHC Study participants at baseline survey. J Epidemiol, 11:s87-s93, 2001 242. Yoshinaga A, Sasaki S, Tsugane S. Sensitivity of self-reports of cancer in a population-based prospective study: JPHC Sutdy Cohort I. J Clin Epidemiol, 54:741-746, 2001 243. Tsubono Y, Sasaki S, Kobayashi M, Akabane M, Tsugane S. Food composition and empirical weight methods in predicting nutrient intakes from food frequency questionnaire. Ann Epidemiol, 11:213-218, 2001 244. Kobayashi M, Sasaki S, Kawabata T, Hasegawa K, Akabane M, Tsugane S. Single measurement of serum phospholipid fatty acid as a biomarker of specific fatty acid intake in middle-aged Japanese men. Eur J Clin Nutr, 55:643-650, 2001 245. Takahashi Y, Sasaki S, Tsugane S. Development and validation of specific carotene food composition tables for use in nutritional epidemiologic studies for Japanese populations. J Epidemiol, 11:266-275, 2001 246. Takahashi Y, Noda M, Tsugane S, Kimura S, Akanuma Y, Kuzuya T, Ohashi Y, Kadowaki T. Importance of standardization of hemoglobin A1c in the analysis of factors that predict hemoglobin A1c levels in non-diabetic residents of three distinct areas of Japan. Diabetes Res Clin Pract, 53:91-97, 2001 247. Tatemichi M, Kabuto M, Tsugane S. Effect of smoking on serum pepsinogen I level depends on serological status of Helicobacter pylori. Jpn J Cancer Res, 92:243-248, 2001 248. Sasaki S, Yanagibori R. Association between current nutrient intakes and bone mineral density at calcaneus in pre- and postmenopausal Japanese women. J Nutr Sci Vitaminol, 47:289-294, 2001 249. Hanaoka T, Sugimura H, Nagura K, Ihara M, Li X-J, Hamada GS, Nishimoto IN, Kowalski LP, Yokota J, Tsugane S. hOGG1 exon7 polymorphism and gastric cancer in case-control studies of Japanese Brazilians and non-Japanese Brazilians. Cancer Lett, 170:53-61, 2001 250. Fujioka N, Fahey MT, Hamada GS, Nishimoto IN, Kowalski LP, Iriya K, Rodrigues JJG, Tajiri H, Tsugane S. Serological immunoglobulin G antibody titers to Helicobacter pylori in Japanese Brazilian and non-Japanese Brazilian gastric cancer patients and controls in Sao Paulo. Jpn J Cancer Res, 92:829-835, 2001 251. Koriyama C, Akiba S, Iriya K, Yamaguti T, Hamada GS, Itoh T, Eizuru Y, Aikou T, Watanabe S, Tsugane S, Tokunaga M. Epstein-barr virus-associated gastric carcinoma in Japanese Brazilians and non-Japanese Brazilian in Sao Paulo. Jpn J Cancer Res, 92:911-917, 2001 252. Karita K, Hamada GS, Tsugane S. Comparison of selenium status between Japanese living in Tokyo and Japanese Brazilians in Sao Paulo, Brazil. Asia Pacific J Clin Nutr, 10:197-199, 2001 253. Zhang J, Ichiba M, Hara K, Zhang S, Hanaoka T, Pan G, Yamano Y, Takahashi K, Tomokuni K. Urinary 1-hydroxypyrene in coke oven workers relative to exposure, alcohol consumption, and metabolic enzymes. Occup Environ Med, 58:716-721, 2001 254. Oba SM, Wang Y-J, Song J-P, Li Z-Y, Kobayashi K, Tsugane S, Hamada GS, Tanaka M, Sugimura H. Genomic structure and loss of heterozygosity of EPHB2 in colorectal cancer. Cancer Lett, 164:97-104, 2001 255. Takamochi K, Nagai K, Yoshida J, Suzuki K, Ohde Y, Nishimura M, Sasaki S, Nishiwaki Y. Pathologic NO status in pulmonary adenocarcinoma is predictable by combining serum carcinoembryonic antigen level and computed tomographic findings. J Thorac Cardiovasc Surg, 122:325-330, 2001 256. Homma S, Ishii T, Malcom GT, Zieske AW, Strong JP, Tsugane S, Hirose N. Histopathological modifications of early atherosclerotic lesions by risk factors -findings in PDAY subjects. Atherosclerosis, 156:389-399, 2001 257. Satoh M, Matsumoto T, Imai M, Sugimoto M, Tsugane S, Furuichi Y, Goto M. Prevalence of werner syndrome gene mutations in the Japanese population: a genetic epidemiological study. Gann Monogr Cancer Res, 49:19-25, 2001 22. Investigative Treatment Division 258. Kimura H, Weisz A, Ogura T, Hitomi Y, Kurashima Y, Hashimoto K, D'Acquisto F, Makuuchi M, Esumi H. Identification of hypoxia-inducible factor 1 ancillary sequence and its function in vascular endothelial growth factor gene induction by hypoxia and nitric oxide. J Biol Chem, 276:2292-2298, 2001 259. Imamura K, Ogura T, Kishimoto A, Kaminishi M, Esumi H. Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole-4-carboxamide-1-b-D-ribofuranoside, in a human hepatocellular carcinoma cell line. Biochem Biophys Res Commun, 287:562-567, 2001 260. Nomura S, Tatemichi M, Kaminishi M, Esumi H. A novel method for detecting single glandular intestinal metaplasia in the mucosal surface of the fixed stomach using methylene blue. Jpn Cancer Res, 92:659-665, 2001 261. Kawasaki H, Ogura T, Yokose T, Nagai K, Nishiwaki Y, Esumi H. p53 gene alteration in atypical epithelial lesions and carcinoma in patients with idiopathic pulmonary fibrosis. Hum Pathol, 32:1043-1049, 2001 262. Takamochi K, Ogura T, Suzuki K, Kawasaki H, Kurashima Y, Yokose T, Ochiai A, Nagai K, Nishiwaki Y, Esumi H. Loss of heterozygosity on chromosomes 9q and 16p in atypical adenomatous hyperplasia concomitant with adenocarcinoma of the lung. Am J Pathol, 159:1941-1948, 2001 263. Bermont L, Lamielle F, Lorchel F, Fauconnet S, Esumi H, Weisz A, Adessi G. Insulin upregulates VEGF and stabilizes its messengers in endometrial adenocarcinoma cells. J Clin Endocrinol Metab, 86:363-368, 2001 23. Psycho-Oncology Division 264. Akechi T, Okamura H, Nishiwaki Y, Uchitomi Y. Psychiatric disorders and associated and predictive factors in patients with unresectable nonsmall cell lung carcinoma. Cancer, 92:2609-2622, 2001 265. Akechi T, Okuyama T, Imoto S, Yamawaki S, Uchitomi Y. Biomedical and psychosocial determinants of psychiatric morbidity among postoperative ambulatory breast cancer patients. Breast Cancer Res Treat, 65:195-202, 2001 266. Akechi T, Nakano T, Okamura H, Ueda S, Akizuki N, Nakanishi T, Yoshikawa E, Matsuki H, Hirabayashi E, Uchitomi Y. Psychiatric disorders in cancer patients: descriptive analysis of 1721 psychiatric referrals at two Japanese cancer center hospitals. Jpn J Clin Oncol, 31:188-194, 2001 267. Kagaya A, Kugaya A, Takebayashi M, Fukue-Sasaki M, Saekit, Yamawaki S, Uchitomi Y. Plasma concentrations of interleukin-1b, interleukin-6, soluble interleukin-2 receptor and tumor necrosis factor a of depressed patients in Japan. Neuropsychobiology, 43:59-62, 2001 268. Uchitomi Y, Kugaya A, Akechi T, Nakano T, Wenner M, Okamura H, Takebayashi M, Kagaya A, Saeki T, Yamawaki S. Three sets of diagnostic criteria for major depression and correlations with serotonin-induced platelet calcium mobilization in cancer patients. Psychopharmacology, 153:244-248, 2001 269. Murakami Y, Gondo N, Okamura H, Akechi T, Uchitomi Y. Guilt from negative genetic test findings: a longitudinal study. Am J Psychiatry, 158:1929, 2001 270. Okano Y, Okamura H, Watanabe T, Narabayashi M, Katsumata N, Ando M, Adachi I, Kazuma K, Akechi T, Uchitomi Y. Mental adjustment to first recurrence and correlated factors in patients with breast cancer. Breast Cancer Res Treat, 67:255-262, 2001 271. Fukui S, Kugaya A, Kamiya M, Koike M, Okamura H, Nakanishi T, Wenner M, Imoto S, Kanagawa K, Uchitomi Y. Participation in psychosocial group intervention among Japanese women with primary breast cancer and its associated factors. Psycho-Oncology, 10:419-427, 2001 272. Uchitomi Y, Nakano T. Hippocampal volume, memory function, and reexperience symptoms of PTSD among cancer survivors. In: Koho M, Shapiro CM, Gaviria M, Yoshio M (eds), Contemp Neuropsy. Springer, pp 455-459, 2001 273. Uchitomi Y. Truth-telling in cancer care: the Japanese perspective. In: Eduardo B, Russell PK (eds), Top Palliat Care. Oxford University Press, pp 95-105, 2001 274. Uchitomi Y, Mikami I, Kugaya A, Nakano T, Okuyama T, Akechi T, Okamura H. Physician support and patient psychologic responses after surgery for nonsmall cell lung carcinoma: a prospective observational study. Cancer, 92:1926-1935, 2001 275. Okuyama T, Tanaka K, Akechi T, Kugaya A, Okamura H, Nishiwaki Y, Hosaka T, Uchitomi Y. Fatigue in ambulatory patients with advanced lung cancer: prevalence, correlated factors, and screening. J Pain Symptom Manage, 22:554-564, 2001 276. Akechi T, Okamura H, Yamawaki S, Uchitomi Y. Why do some cancer patients with depression desire an early death and others do not? Psychosomatics, 42:141-145, 2001