List of Papers Published in 2002

List of Papers Published in 2002

1. Pathology Division

1. Saito Y, Kanai Y, Sakamoto M, Saito H, Ishii H, Hirohashi S. Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomet hyl ati on on peri cent romeri c sat el l i t e regi ons duri ng human hepatocarcinogenesis. Proc Natl Acad Sci USA, 99:10060-10065, 2002
2. Tsuda H, Takarabe T, Kanai Y, Fukutomi T, Hirohashi S. Correlation of DNA hypomethylation at pericentromeric heterochromatin regions of chromosomes 16 and 1 with histological features and chromosomal abnormalities of human breast carci-nomas. Am J Pathol, 161:859-866, 2002
3. Tsuda H, Takarabe T, Okada S, Uchida H, Kasamatsu T, Yamada T, Tsunematsu R, Ohmi K, Hirohashi S. Different pattern of loss of heterozygosity among endocervical-type adenocarcinoma, endometrioid-type adenocarcinoma and adenoma malignum of the uterine cervix. Int J Cancer, 98:713-717, 2002
4. Okada S, Tsuda H, Takarabe T, Yoshikawa H, Taketani Y, Hirohashi S. Allelotype analysis of common epithelial ovarian cancers with special reference to comparison between clear cell adenocarcinoma with other histological types. Jpn J Cancer Res, 93:798-806, 2002
5. Yokoi S, Yasui K, Saito-Ohara F, Koshikawa K, Iizasa T, Fujisawa T, Terasaki T, Horii A, Takahashi T, Hirohashi S, Inazawa J. A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers. Am J Pathol, 161:207-216, 2002
6. Imoto I, Tsuda H, Hirasawa A, Miura M, Sakamoto M, Hirohashi S, Inazawa J. Expression of cIAP1, a target for 11q22 amplification, correlates with resistance of cervical cancers to radiotherapy. Cancer Res, 62:4860-4866, 2002
7. Ino Y, Gotoh M, Sakamoto M, Tsukagoshi K, Hirohashi S. Dysadherin, a cancer-associated cell membrane glycoprotein, down-regulates E-cadherin and promotes metastasis. PNAS, 99:365-370, 2002
8. Nam J-S, Ino Y, Sakamoto M, Hirohashi S. Src family kinase inhibitor PP2 restores the E-cadherin/catenin cell adhesion system in human cancer cells and reduces cancer metastasis. Clin Cancer Res, 8:2430-2436, 2002
9. Nam J-S, Ino Y, Sakamoto M, Hirohashi S. Ras farnesylation inhibitor FTI-277 restores the E-cadherin/catenin cell adhesion system in human cancer cells and reduces cancer metastasis. Jpn J Cancer Res, 93:1020-1028, 2002
10. Ono Y, Nakanishi Y, Gotoh M, Sakamoto M, Hirohashi S. Epidermal growth factor receptor gene amplification is correlated with laminim-5 g2 chain expression in oral squamous cell carcinoma cell lines. Cancer Lett, 175:197-204, 2002
11. Katoh K, Nakanishi Y, Akimoto S, Yoshimura K, Takagi M, Sakamoto M, Hirohashi S. Correlation between laminin-5 g2 chain expression and epidermal growth factor receptor expression and its clinicopathological significance in squamous cell carcinoma of the tongue. Oncology, 62:318-326, 2002
12. Niki T, Kohno T, Iba S, Moriya Y, Takahashi Y, Saitoh M, Maeshima A, Yamada T, Matsuno Y, Fukayama M, Yokota J, Hirohashi S. Frequent co-localization of cox-2 and laminin-5 g2 chain at the invasive front of eary-stage lung adenocarcinomas. Am J Pathol, 160:1129-1141, 2002
13. Aoki S, Nakanishi Y, Akimoto S, Moriya Y, Yoshimura K, Kitajima M, Sakamoto M, Hirohashi S. Prognostic significance of laminin-5g2 chain expression in colorectal carcinoma: Immunohistochemical analysis of 103 cases. Dis Colon Rectum, 45:1520-1527, 2002
14. Nakanishi K, Sakamoto M, Yasuda J, Takamura M, Fujita N, Tsuruo T, Todo S, Hirohashi S. Critical involvement of the phosphatidylinositol 3-kinase/Akt pathway in anchorage-independent growth and hematogeneous intrahepatic metastasis of liver cancer. Cancer Res, 62:2971-2975, 2002
15. Sekine S, Shibata T, Sakamoto M, Hirohashi S. Target disruption of the mutant b-catenin gene in colon cancer cell line HCT116: preservation of its malignant phenotype. Oncogene, 21:5906-5911, 2002
16. Sekine S, Shibata T, Yamauchi Y, Nakanishi Y, Shimoda T, Sakamoto M, Hirohashi S. b-catenin mutations in sporadic fundic gland polyps. Virchows Arch, 440:381-386, 2002
17. Sekine S, Shibata T, Kokubu A, Morishita Y, Noguchi M, Nakanishi Y, Sakamoto M, Hirohashi S. Craniopharyngiomas of adamantinomatous type harbor b-catenin gene mutations. Am J Pathol, 161:1997-2001, 2002
18. Saito A, Fujii G, Sato Y, Gotoh M, Sakamoto M, Toda G, Hirohashi S. Detection of genes expressed in primary colon cancers by in situ hybridisation: overexpression of RACK 1. J Clin Pathol, 55:34-39, 2002
19. Gotoh M, Sakamoto M, Kanetaka K, Chuuma M, Hirohashi S. Overexpression of osteopontin in hepatocellular carcinoma. Pathol Int, 52:19-24, 2002
20. Shimamura T, Sakamoto M, Ino Y, Shimada K, Kosuge T, Sato Y, Tanaka K, Sekihara H, Hirohashi S. Clinicopathological significance of galectin-3 expression in ductal adenocarcinoma of the pancreas. Clin Cancer Res, 8:2570-2575, 2002
21. Hasegawa T, Yamamoto S, Nojima T, Hirose T, Nikaido T, Yamashiro K, Matsuno Y. Validity and reproducibility of histologic diagnosis and grading for adult soft-tissue sarcomas. Hum Pathol, 33:111-115, 2002
22. Muroya K, Nishimura G, Douya H, Hasegawa T, Ogata T. Diaphyseal medullary stenosis with malignant fibrous histiocytoma: further evidence for loss of heterozygosity involving 9p21-22 in tumor tissue. Gene Chromosom Cancer, 33:326-328, 2002
23. Yachida S, Fukushima N, Sakamoto M, Matsuno Y, Kosuge T, Hirohashi S. Implications of peritoneal washing cytology in patients with potentially resectable pancreatic cancer. Br J Surg, 89:573-578, 2002
24. Tsuda H, Sasano H, Akiyama F, Kurosumi M, Hasegawa T, Osamura YR, Sakamoto G. Evaluation of interobserver agreement in scoring immunohistochemical results of HER-2/neu(c-erbB-2)expression detected by Hercep Test, Nichirei polyclonal anti-body, CB11 and TAB250 in breast carcinoma. Pathol Int, 52:126-134, 2002
25. Sugiura T, Kato H, Tachimori Y, Igaki H, Yamaguchi H, Nakanishi Y. Second primary carcinoma in the gastric tube constructed as an esophageal substitute after esophagectomy. J Am Coll Surg, 194:578-583, 2002
26. Sato M, Fukutomi T, Akashi-Tanaka S, Miyakawa K, Yamamoto N, Hasegawa T. Accuracy in estimating tumor extension according to mammographic subtypes in patients with ductal carcinoma in situ. Jpn J Clin Oncol, 32:157-161, 2002
27. Hishida T, Nakanishi Y, Shimoda T, Igaki H, Tachimori Y, Kato H, Yamaguchi H, Iinuma G. Esophageal basaloid carcinoma with marked myoepithelial differentia-tion. Pathol Int, 52:313-317, 2002
28. Matsuo K, Fukutomi T, Watanabe T, Hasegawa T, Tsuda H, Akashi-Tanaka S. Con-cordance in pathological response to neoadjuvant chemotherapy between invasive and noninvasive components of primary breast carcinomas. Breast Cancer, 9:75-81, 2002
29. Matsuo K, Fukutomi T, Akashi-Tanaka S, Hasegawa T, Tsuda H. Histological grade, p53, HER2 and hormone receptor status of synchronous bilateral breast carcinoma. Breast Cancer, 9:127-133, 2002
30. Matsuo K, Fukutomi T, Hasegawa T, Akashi-Tanaka S, Nanasawa T, Tsuda H. Histological and immunohistochemical analysis of apocrine breast carcinoma. Breast Cancer, 9:43-49, 2002
31. Okada S, Tsuda H, Ohmi K, Kasamatsu T, Yamada T, Tsunematsu R, Sumi M, Tokuuye K, Yoshikawa H, Hirohashi S. Immature glandular features in squamous cell carcinoma of the uterine cervix as an independent indicator of resistance to radiotherapy. Int J Gynecol Cancer, 12:277-285, 2002
32. Hasegawa T, Matsuno Y, Shimoda T, Hirohashi S. Gastrointestinal stromal tumor: consistent CD117 immunostaining for diagnosis, and prognostic classification based on tumor size and MIB-1 grade. Hum Pathol, 33:669-676, 2002
33. Hasegawa T, Yamamoto S, Yokoyama R, Umeda T, Matsuno Y, Hirohashi S. Prognostic significance of grading and staging systems using MIB-1 score in adult patients with soft tissue sarcoma of the extremities and trunk. Cancer, 95:843-851, 2002
34. Maeshima A, Sakamoto M, Hirohashi S. Mixed mucinous-type and non-mucinous-type adenocarcinoma of the lung: immunohistochemical examination and K-ras gene mutation. Virchows Arch, 440:598-603, 2002
35. Douya H, Yokoyama R, Beppu Y, Hasegawa T. Malignant fibrous histiocytoma associated with diaphyseal medullary stenosis. Clin Orthop, 400:211-216, 2002
36. Hasegawa T, Yamamoto S, Matsuno Y. Quantitative immunohistochemical evaluation of MIB-1 labeling index in adult soft-tissue sarcomas by computer-assisted image analysis. Pathol Int, 52:433-437, 2002
37. Takei H, Asamura H, Maeshima A, Suzuki K, Kondo H, Niki T, Yamada T, Tsuchiya R, Matsuno Y. Large cell neuroendocrine carcinoma of the lung: a clinicopathologic study of eighty-seven cases. J Thorac Cardiovasc Surg, 124:285-292, 2002
38. Yachida S, Fukushima N, Kanai Y, Nimura S, Shimada K, Yamamoto J, Sakamoto M. Pancreatic metastasis from renal cell carcinoma extending into the main pancreatic duct: a case report. Jpn J Clin Oncol, 32:315-317, 2002
39. Kubo M, Sakamoto M, Fukushima N, Yachida S, Nakanishi Y, Shimoda T, Yamamoto J, Moriya Y, Hirohashi S. Less aggressive features of colorectal cancer with liver metastases showing macroscopic intrabiliary extension. Pathol Int, 52:514-518, 2002
40. Koide N, Akashi-Tanaka S, Fukutomi T, Nanasawa T, Hasegawa T. Nodular mucinosis of the breast: a case report with clinical and imaging findings. Breast Cancer, 9:261-264, 2002
41. Tateishi U, Hasegawa T, Kusumoto M, Oyama T, Ishikawa H, Moriyama N. Desmoplastic small round cell tumor: imaging findings associated with clinicopathologic features. J Comput Assist Tomogr, 26:579-583, 2002
42. Tateishi U, Hasegawa T, Kusumoto M, Yokoyama R, Moriyama N. Radiologic manifestations of proximal-type epithelioid sarcoma of the soft tissues. AJR, 179:973-977, 2002
43. Tateishi U, Kusumoto M, Hasegawa T, Yokoyama R, Moriyama N. Primary malignant fibrous histiocytoma of the chest wall: CT and MR appearance. J Comput Assist Tomogr, 26:558-563, 2002
44. Ozaki T, Schaefer K-L, Wai D, Yokoyama R, Ahrens S, Diallo R, Hasegawa T, Shimoda T, Hirohashi S, Kawai A, Naito N, Morimoto Y, Inoue H, Boecker W, Juergens H, Winkelmann W, Dockhorn-Dworniczak B, Poremba C. Population-based genetic alterations in Ewing's tumors from Japanese and European Caucasian patients. Anal Oncol, 13:1656-1664, 2002
45. Nakanishi Y. Histopathologic findings predicting lymph node metastasis and prognosis of patients with superficial esophageal carcinoma. In: Imamura M (ed), Super-ficial Esophageal Neoplasm: Pathology, Diagnosis, and Therapy. Tokyo, Springer-Verlag, pp 83-94, 2002
46. Yachida S, Fukushima N, Nakanishi K, Shimada K, Kosuge T, Sakamoto M. Minute pancreatic adenocarcinoma presenting with stenosis of the main pancreatic duct. Pathol Int, 52:607-611, 2002
47. Maeshima AM, Niki T, Maeshima A, Yamada T, Kondo H, Matsuno Y. Modified scar grade: a prognostic indicator in small peripheral lung adenocarcinoma. Cancer, 95:2546-2554, 2002
48. Yachida S, Fukushima N, Nakanishi Y, Nimura S, Sato M, Shimada K, Miura K, Sakamoto M. Phosphoglyceride crystal deposition disease presenting as multiple paragastric masses. Dig Dis Sci, 47:1413-1418, 2002
2. Biochemistry Division

49. Nakagama H, Ochiai M, Ubagai T, Tajima R, Fujiwara K, Sugimura T, Nagao M. A rat colon cancer model induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, PhIP. Mutat Res, 506-507:137-144, 2002
50. Ubagai T, Ochiai M, Kawamori T, Iami H, Sugimura T, Nagao M, Nakagama H. Efficient induction of rat large intestinal tumors with a new spectrum of mutations by intermittent administration of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in combination with a high fat diet. Carcinogenesis, 23:197-200, 2002
51. Osawa E, Nakajima A, Yoshida S, Omura M, Nagase H, Ueno N, Wada K, Matsuhashi N, Ochiai M, Nakagama H, Sekihara H. Chemoprevention of precursors to colon cancer by dehydroepiandrosterone (DHEA). Life Sci, 70:2623-2630, 2002
52. Ochiai M, Imai H, Sugimura T, Nagao M, Nakagama H. Induction of intestinal tu-mors and lymphomas in C57BL/6N mice by a food-borne carcinogen, 2-amino-1-methyl- 6-phenylimidazo[4,5-b]pyridine. Jpn J Cancer Res, 93:478-483, 2002
53. Nagao M, Ushijima T, Watanabe N, Okochi E, Ochiai M, Nakagama H, Sugimura T. Studies on mammary carcinogenesis induced by a heterocyclic amine, 2-amino-1-methyl- 6-phenylimidazo[4,5-b]pyridine, in mice and rats. Environ Mol Mutagen, 39:158-164, 2002
54. Suzui M, Okuno M, Tanaka T, Nakagama H, Moriwaki H. Enhanced colon carcinogenesis induced by azoxymethane in min mice occurs via a mechanism independent of b-catenin mutation. Cancer Lett, 183:31-41, 2002
55. Inamori H, Takagi S, Tajima R, Ochiai M, Ubagai T, Sugimura T, Nagao M, Nakagama H. Frequent and multiple mutations at minisatellite loci in sporadic human colorectal and gastric cancers - possible mechanistic differences from microsatellite instability in cancer cells. Jpn J Cancer Res, 93:382-388, 2002
56. Fukuda H, Katahira M, Tsuchiya N, Enokizono Y, Sugimura T, Nagao M, Nakagama H. Unfolding of quadruplex structure in the G-rich strand of the minisatellite repeat by the binding protein UP1. Proc Natl Acad Sci USA, 99: 12685-12690, 2002
57. Tsuchiya N, Fukuda H, Sugimura T, Nagao M, Nakagama H. LRP130, a protein containing nine pentatricopeptide repeat (PPR) motifs, interacts with a single-stranded cytosine-rich sequence of mouse hypervariable minisatellite Pc-1. Eur J Biochem, 269:2927-2933, 2002
58. Masutani M, Miwa M. Poly(ADP-ribose) polymerase and cancer: In relation to the lectures presented by Dr. Gilbert de Murcia. Jpn J Clin Oncol, 32:483-487, 2002
59. Ikejima M, Nozaki T, Kurata S, Natori S, Esumi H, Sugimura T, Masutani M. Purification and characterization of poly(ADP-ribose) polymerase from Sarcophaga peregrina. Proc Jpn Acad Ser B, 78: 282-285, 2002
60. Cross JC, Hemberger M, Lu Y, Nozaki T, Whiteley K, Masutani M. Adamson SL. Trophoblast functions, angiogenesis and remodeling of the maternal vasculature in placenta. Mol Cell Endocrinol, 187:207-212, 2002
61. Masutani M, Shimokawa T, Igarashi M, Hamada M, Shibata A, Oami S, Nozaki T, Nakagama H, Sugimura T, Takeuchi T, Hori M. Inhibition of poly(ADP-ribose) glycohydrolase activity by cyclic peptide antibiotics containing piperazic acid resi-dues. Proc Jpn Acad Ser. B, 78:15-17, 2002.
3. Experimental Pathology and Chemotherapy Division

62. Asamoto M, Toriyama-Baba H, Ohnishi T, Naito A, Ota T, Ando A, Ochiya T, Tsuda H. Transgenic rats carrying human c-Ha-ras proto-oncogene are highly susceptible to N-nitrosomethylbenzylamine induction of esophageal tumorigenesis. Jpn J Cancer Res, 93:744-751, 2002
63. Asamoto M, Ota T, Toriyama-Baba H, Hokaiwado N, Naito A, Tsuda H. Mammary carcinomas induced in human c-Ha-ras proto-oncogene transgenic rats are estrogen- independent, but responsive to d-limonene treatment. Jpn J Cancer Res, 93:32-35, 2002
64. Han BS, Fukamachi K, Takasuka N, Ohnishi T, Maeda M, Yamasaki T, Tsuda H. Inhibitory effects of 17b-estradiol and 4-n-octylphenol on 7,12-dimethylbenz [a]anthracene-induced mammary tumor development in human c-Ha-ras proto-oncogene transgenic rats. Carcinogenesis, 23:1209-1215, 2002
65. Fukamachi K, Matsuoka Y, Ohno H, Hamaguchi T, Tsuda H. Neuronal leucine-rich repeat protein-3 amplifies MAPK activation by epidermal growth factor through a carboxyl-terminal region containing endocytosis motifs. J Biol Chem, 277: 43549-43552, 2002
66. Fujita K, Ohnishi T, Sekine K, Iigo M, Tsuda H. Down-regulation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline(MeIQx)-induced CYP1A2 expression is associated with bovine lactoferrin inhibition of MeIQx-induced liver and colon carcinogenesis in rats. Jpn J Cancer Res, 93:616-625, 2002
67. Tsuda H, Sekine K, Fujita K, Iigo M. Cancer prevention by bovine lactoferrin and underlying mechanisms:a review of experimental and clinical studies. Biochem Cell Biol, 80:131-136, 2002
68. Kohno H, Tanaka T, Kawabata K, Hirose Y, Sugie S, Tsuda H, Mori H. Silymarin, a naturally occurring polyphenolic antioxidant flavonoid, inhibits azoxymethane-in-duced colon carcinogenesis in male F344 rats. Int J Cancer, 101: 461-468, 2002
69. Takasuka N, Naito A, Fukamachi K, Murakoshi M, Nishino H, Tsuda H. Modifying effects of carotenoids in a rat multi-organ carcinogenesis model: inhibition in the liver but promotion of lung tumor development. Proc Jpn Acad, 78:33-37, 2002
70. Fukushima S, Wanibuchi H, Morimura K, Wei M, Nakae D, Konishi Y, Tsuda H, Uehara N, Imaida K, Shirai T, Tatematsu M, Tsukamoto T, Hirose M, Furukawa F, Wakabayashi K, Totsuka Y. Lack of a dose-response relationship for carcinogenicity in the rat liver with low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline or N-nitrosodiethylamine. Jpn J Cancer Res, 93: 1076-1082, 2002
71. Mitsumori K, Yoshida M, Iwata H, Katsuda O, Kouchi M, Tsuda H. Classification of renal proliferative lesions in rats and/or mice and their diagnostic problems: report from the working group of the Japanese Society of Toxicologic Pathology. J Toxicol Pathol, 15:175-190, 2002
72. Tajima K, Tsuda H, Moore MA. The contribution of Asian countries to the international cancer prevention effort - reflections from a glance at the literature. Asian Pacific J Cancer Prev, 3:1-2, 2002
73. Tajima K, Tsuda H, Moore MA. Requirement for Asian Pacific collaboration in assessment of nutritional factors impacting on cancer development. Asian Pacific J Cancer Prev, 3:93-96, 2002
74. Tsuda H, Moore MA. Cancer screening: a review with particular attention to areas for future international research efforts. Asian Pacific J Cancer Prev, 3:99-123, 2002
75. Moore MA, Tsuda H. Food and play preferences - does cancer prevention require targeting the child? Asian Pacific J Cancer Prev, 3:279-280, 2002
76. Moore MA, Tsuda H. Smoking-related research in the Asian-Pacific countries. Asian Pacific J Cancer Prev, 3:291-304, 2002
77. Doungchawee G, Khoaprasert Y, Kongtim S, Thamavit W, Tajima K, Moore MA, Tsuda H. Use of wild rodents for environmental monitoring - comparison of rats in Bangkok and rural areas of Thailand. Asian Pacific J Cancer Prev, 3:367-368, 2002
4. Biology Division

78. Nishioka M, Kohno T, Tani M, Yanaihara N, Tomizawa Y, Otsuka A, Sasaki S, Kobayashi K, Niki T, Maeshima A, Sekido Y, Minna JD, Sone S, Yokota J. MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer. PNAS, 99:12269-12274, 2002
79. Tomizawa Y, Kohno T, Kondo H, Otsuka A, Nishioka M, Niki T, Yamada T, Maeshima A, Yoshimura K, Saito R, Minna JD, Yokota J. Clinicopathological significance of epigenetic inactivation of RASSF1A at 3p21.3 in stage I lung adenocarcinoma. Clin Cancer Res, 8:2362-2368, 2002
80. Park Y-B, Park MJ, Kimura K, Shimizu K, Lee SH, Yokota J. Alterations in the INK4a/ARF locus and their effects on the growth of human osteosarcoma cell lines. Cancer Genet Cytogenet, 133:105-111, 2002
81. Woo IS, Kohno T, Inoue K, Ishii S, Yokota J. Infrequent mutations of the activating transcription factor-2 gene in human lung cancer, neuroblastoma and breast cancer. Int J Oncol, 20:527-531, 2002
82. Koyama T, Tago K, Nakamura T, Ohwada S, Morishita Y, Yokota J, Akiyama T. Mutation and expression of the b-catenin-interacting protein ICAT in human colorectal tumors. Jpn J Clin Oncol, 32:358-362, 2002
83. Yabuta T, Shinmura K, Tani M, Yamaguchi S, Yoshimura K, Katai H, Nakajima T, Mochiki E, Tsujinaka T, Takami M, Hirose K, Yamaguchi A, Takenoshita S, Yokota J. E-cadherin gene variants in gastric cancer families whose probands are diagnosed with diffuse gastric cancer. Int J Cancer, 101:434-441, 2002
84. Yoshizumi M, Kohno T, Nishioka M, Sawada T, Yokota J. Gene Specific-Primer Extension Preamplification (GS-PEP), a simple method to increase the copy number of a gene prior to PCR amplification. Proc Jpn Acad Ser B, 78:123-128, 2002
85. Kitagawa Y, Inoue K, Sasaki S, Hayashi Y, Matsuo Y, Lieber MR, Mizoguchi H, Yokota J, Kohno T. Prevalent involvement of illegitimate V(D)J recombination in chromosome 9p21 deletions in lymphoid leukemia. J Biol Chem, 277:46289-46297, 2002
86. Ariyoshi N, Miyamoto M, Umetsu Y, Kunitoh H, Dosaka-Akita H, Sawamura Y, Yokota J, Nemoto N, Sato K, Kamataki T. Genetic polymorphism of CYP2A6 gene and tobacco- induced lung cancer risk in male smokers. Cancer Epidemiol Biomarkers Prev, 11:890-894, 2002
87. Sunaga N, Kohno T, Yanagitani N, Sugimura H, Kunitoh H, Tamura T, Takei Y, Tsuchiya S, Saito R, Yokota J. Contribution of the NQO1 and GSTT1 polymorphisms to lung adenocarcinoma susceptibility. Cancer Epidemiol Biomarkers Prev, 11:730-738, 2002
88. Yanagitani N, Kohno T, Sunaga N, Kunitoh H, Tamura T, Tsuchiya S, Saito R, Yokota J. Localization of a human lung adenocarcinoma susceptibility locus, possibly syntenic to the mouse Pas1 locus, in the vicinity of the D12S1034 locus on chromosome 12p11.2-p12.1. Carcinogenesis, 23:1177-1183, 2002
89. Shimizu S, Nagasawa T, Katoh O, Komatsu N, Yokota J, Morishita K. EVI1 is expressed in megakaryocyte cell lineage and enforced expression of EVI1 in UT-7/GM cells induces megakaryocyte differentiation. Biochem Biophys Res Commun, 292:609-616, 2002
90. Yamaguchi S, Shinmura K, Saitoh T, Takenoshita S, Kuwano H, Yokota J. A single nucleotide polymorphism at the splice donor site of the human MYH base excision repair gene results in reduced translation efficiency of its transcripts. Genes Cells, 7:461-474, 2002
91. Kimura K, Nakano T, Park Y-B, Tani M, Tsuda H, Beppu Y, Moriya H, Yokota J. Establishment of human osteosarcoma cell lines with high metastatic potential to lungs and their utilities for therapeutic studies on metastatic osteosarcoma. Clin Exp Metastasis, 19:477-485, 2002
92. Shindo-Okada N, Takeuchi K, Han B-S, Nagamachi Y. Establishment of cell lines with high and low metastatic potential from A549 human lung adenocarcinoma. Jpn J Cancer Res, 93:50-60, 2002
5. Pharmacology Division

93. Ikarashi Y, Kato K, Yoshida M, Wakasugi H. U1B3.3 monoclonal antibody recognizes a precursor of NK1.1 ⁺ cytotoxic T cells generated by interleukin-2. Proc Jpn Acad Ser B, 78:91-95, 2002
94. Saitoh T, Kanda Y, Kami M, Kato K, Shoji N, Kanai S, Ohnishi T, Kawano Y, Nakai K, Ogasawara T, Matsubara H, Makimoto A, Tanosaki R, Tobinai K, Wakasugi H, Takaue Y, Mineishi S. Therapeutic potential of a reduced-intensity preparative regimen for allogeneic transplantation with cladribine, busulfan, and antithymocyte globulin against advanced/refractry acute leukemia/lymphoma. Clin Cancer Res, 8:1014-1020, 2002
95. Lee J-J, Takei M, Hori S, Inoue Y, Harada Y, Tanosaki R, Kanda Y, Kami M, Makimoto A, Mineishi S, Kawai H, Shimosaka A, Heike Y, Ikarashi Y, Wakasugi H, Takaue Y, Hwang T-J, Kim H-J, Kakizoe T. The role of PGE₂ in the differentiation of dendritic cells: how do dendritic cells influence T-cell polarization and chemokine receptor expression? Stem Cells, 20:448-459, 2002
96. Matsuda K, Matsuda S, Saito M, Ito Y. Separation of phospholipids and glycolipids using analytical toroidal-coil countercurrent chromatography. I. Separation of human brain lipids. J. Liq. Chrom. & Rel. Technol., 25 : 1267-1281, 2002.
97. Shirakawa K, Kobayashi H, Heike Y, Kawamoto S, Brechbiel MW, Kasumi F, Iwanaga T, Konishi F, Terada M, Wakasugi H. Hemodynamics in vasculogenic mimicry and angiogenesis of inflammatory breast cancer xenograft. Cancer Res, 62:560-566, 2002
98. Kobayashi H, Shirakawa K, Kawamoto S, Saga T, Sato N, Hiraga A, Watanabe I, Heike Y, Togashi K, Konishi J, Brechbiel MW, Wakasugi H. Rapid accumulation and internalization of radiolabeled herceptin in an inflammatory breast cancer xenograft with vasculogenic mimicry predicted by the contrast-enhanced dynamic MRI with the macromolecular contrast agent G6-(1B4M-Gd)256. Cancer Res, 62:860-866, 2002
99. Shirakawa K, Shibuya M, Heike Y, Takashima S, Watanabe I, Konishi F, Kasumi F, Goldman CK, Thomas KA, Bett A, Terada M, Wakasugi H. Tumor-infiltrating endothelial cells and endothelial precursor cells in inflammatory breast cancer. Int J Can-cer, 99:344-354, 2002
100. Shirakawa K, Wakasugi H, Heike Y, Watanabe I, Yamada S, Saito K, Konishi F. Vasculogenic mimicry and pseudo-comedo formation in breast cancer. Int J Cancer, 99:821-828, 2002
101. Shirakawa K, Furuhata S, Watanabe I, Hayase H, Shimizu A, Ikarashi Y, Yoshida T, Terada M, Hashimoto D, Wakasugi H. Induction of vasculogenesis in breast cancer models. Br. J. Cancer, 87 : 1454-1461, 2002.
102. Naruse I, Fukumoto H, Saijo N, Nishio K. Enhanced anti-tumor effect of trastuzumab in combination with cisplatin. Jpn J Cancer Res, 93:574-581, 2002
103. Koh Y, Nishio K, Saijo N. Mechanisms of action of cancer chemotherapeutic agents: topoisomerase inhibitors. In:Malcom RA (ed), Cancer Handbook. UK, Reference Nature Publishing Group, pp 1313-1322, 2002
104. Natsume T, Koh Y, Kobayashi M, Fukumoto H, Takahashi F, Nakamura T, Ohe Y, Saijo N, Nishio K. Enhanced antitumor activities of TZT-1027 against TNF-a or IL-6 secreting Lewis lung carcinoma in vivo. Cancer Chemother Pharmacol, 49:35-47, 2002
105. Fukuoka K, Arioka H, Iwamoto Y, Fukumoto H, Kurokawa H, Ishida T, Tomonari A, Suzuki T, Usuda J, Kanzawa F, Kimura H, Saijo N, Nishio K. Mechanism of vinorelbine-induced radiosensitization of human small cell lung cancer cells. Cancer Chemother Pharmacol, 49:385-390, 2002
106. Naruse I, Ohmori T, Ao Y, Fukumoto H, Kuroki T, Mori M, Saijo N, Nishio K. Antitumor activity of the selective epidermal growth factor receptor-tyrosine kinase inhibitor(EGFR-TKI) IRESSA^R (ZD1839) in an EGFR-expressing multidrug-resistant cell line in vitro and in vivo. Int J Cancer, 98:310-315, 2002
107. Takahashi F, Akutagawa S, Fukumoto H, Tsukiyama S, Ohe Y, Takahashi K, Fukuchi Y, Saijo N, Nisho K. Osteopontin induces angiogenesis of murine neuroblastoma cells in mice. Int J Cancer, 98:707-712, 2002
108. Koh Y, Tsunoda T, Iwahashi M, Yamaue H, Ishimoto K, Tanimura H, Fukumoto H, Nakamura T, Tatsumi Y, Shimizu M, Saijo N, Nishio K. Decreased expression of a2,8 sialyltransferase and increased expression of b1,4 N-acetylgalactosaminyltransferase in gastrointestinal cancers. Exp Biol Med, 227:196-200, 2002
109. Inomata M, Kaneko A, Kunimoto T, Saijo N. In vitro thermo- and thermochemo-sensitivity of retinoblastoma cells from surgical specimens. Int J Hyperthermia, 18:50-61, 2002
6. Cancer Medicine and Biophysics Division

110. Sakurada K, Kitanaka C, Kokubu A, Tomiyama A, Sunayama J, Kayama T, Kuchino Y. A cellular mechanism that reversibly inactivates pancaspase inhibitor zAsp-CH₂-DCB: a potential pitfall causing discrepancy between in vitro and in vivo caspase assays. Biochem Biophys Res Commun, 291:1022-1030, 2002
111. Kitanaka C, Kato K, Ijiri R, Sakurada K, Tomiyama A, Noguchi K, Nagashima Y, Nakagawara A, Momoi T, Toyoda Y, Kigasawa H, Nishi T, Shirouzu M, Yokoyama S, Tanaka Y, Kuchino Y. Increased Ras expression and caspase-independent neuro-blastoma cell death: possible mechanism of spontaneous neuroblastoma regression. J Natl Cancer Inst, 94:358-368, 2002
112. Mochizuki T, Asai A, Saito N, Tanaka S, Katagiri H, Asano T, Nakane M, Tamura A, Kuchino Y, Kitanaka C, Kirino T. Akt protein kinase inhibits non-apoptotic programmed cell death induced by ceramide. J Biol Chem, 277:2790-2797, 2002
113. Nishii W, Maruyama T, Matsuoka R, Muramatsu T, Takahashi K. The unique sites in SulA protein preferentially cleaved by ATP-dependent Lon protease from Escherichia coli. Eur J Biochem, 269:451-457, 2002
114. Sawano Y, Muramatsu T, Hatano K, Nagata K, Tanokura M. Characterization of ge-nomic sequence coding for bromelain inhibitors in pineapple and expression of its recombinant isoform. J Biol Chem, 277:28222-28227, 2002
7. Growth Factor Division

115. Miyake I, Hakomori Y, Shinohara A, Gamou T, Saito M, Iwamatsu A, Sakai R. Activation of anaplastic lymphoma kinase is responsible for hyperphosphorylation of ShcC in neuroblastoma cell lines. Oncogene, 21:5823-5834, 2002
116. Nakamoto T, Suzuki T, Huang J, Matsumura T, Seo S, Honda H, Sakai R, Hirai H. Analysis of gene expression profile in p130Cas-deficient fibroblasts. Biochem Biophys Res Commun, 294:635-641, 2002
117. Huang J, Hamasaki H, Nakamoto T, Honda H, Hirai H, Saito M, Takato T, Sakai R. Differential regulation of cell migration, actin stress fiber organization, and cell transformation by functional domains of Crk-associated substrate. J Biol Chem, 277:27265-27272, 2002
118. Sato K, Sasaki K, Tsao M-S, Yamaguchi K. Peptide differential display of serum-free conditioned medium from cancer cell lines. Cancer Lett, 176:199-203, 2002
119. Sasaki K, Sato K, Akiyama Y, Yanagihara K, Oka M, Yamaguchi K. Peptidomics-based approach reveals the secretion of the 29-residue COOH-terminal fragment of the putative tumor suppressor protein DMBT1 from pancreatic adenocarcinoma cell lines. Cancer Res, 62:4894-4898, 2002
120. Maruyama K, Akiyama Y, Cheng J, Nara-Ashizawa N, Hojo T, Sasaki K, Yamaguchi K. Hamster DEC-205, its primary structure, tissue and cellular distribution. Cancer Lett, 181:223-232, 2002
121. Akiyama Y, Maruyama K, Nara N, Hojo T, Cheng J-Y, Mori T, Wiltrout RH, Yamaguchi K. Antitumor effects induced by dendritic cell-based immunotherapy against established pancreatic cancer in hamsters. Cancer Lett, 184:37-47, 2002
122. Akiyama Y, Maruyama K, Watanabe M, Yamaguchi K. Retroviral-mediated IL-12 gene transduction into human CD34⁺ cell-derived dendritic cells. Int J Oncol, 21:509-514, 2002
123. Akiyama Y, Maruyama K, Mochizuki T, Sasaki K, Takaue Y, Yamaguchi K. Identification of HLA-A24-restricted CTL epitope encoded by the matrix protein pp65 of human cytomegalovirus. Immunol Lett, 83: 21-30, 2002
124. Miyauchi A, Matsuzuka F, Hirai K, Yokozawa T, Kobayashi K, Ito Y, Nakano K, Kuma K, Futami H, Yamaguchi K. Prospective trial of unilateral surgery for nonhereditary medullary thyroid carcinoma in patients without germline RET mutations. World J Surg, 26:1023-1028, 2002
8. Molecular Oncology Division

125. Yokoyama A, Kitabayashi I, Ayton PM, Cleary ML, Ohki M. Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties. Blood, 100:3710-3718, 2002
126. Suhara W, Yoneyama M, Kitabayashi I, Fujita T. Direct involvement of CREB-binding protein/p300 in sequence-specific DNA binding of virus-activated interferon regulatory factor-3 holocomplex. J Biol Chem, 277:22304-22313, 2002
127. Shimada H, Ichikawa H, Ohki M. Potential involvement of the AML1-MTG8 fusion protein in the granulocytic maturation characteristic of the t(8;21) acute myelogenous leukemia revealed by microarray analysis. Leukemia, 16:874-885, 2002
9. Cancer Information and Epidemiology Division

128. Sato Y, Arimoto H, Ishikawa KB, Yoshimura K, Kaneko S, Koshiji M, Takada T, Yamaguchi N. Survival trends of patients treated at the National Cancer Center Hospital, Japan, from 1962 to 1994. Jpn J Clin Oncol, 32:181-186, 2002
129. Kaneko S, Nomura K, Yoshimura T, Yamaguchi N. Trend of brain tumor incence by histological subtypes in Japan: estimation from the Brain Tumor Registry of Japan. J Neurooncol, 60:61-69, 2002
130. Kaneko S, Yoshimura T, Ikemura K, Shirasuna K, Kusukawa J, Ohishi M, Shiba R, Sunakawa H, Tominaga K, Sugihara K, Shinohara M, Katsuki T, Yanagisawa S, Kurokawa H, Mimura T, Ikeda H, Yamabe S, Ozeki S. Primary neck management among patients with cancer of the oral cavity without clinical nodal metastases: a decision and sensitivity analysis. Head Neck, 24:582-590, 2002
131. Sobue T, Yamamoto S, Hara M, Sasazuki S, Sasaki S, Tsugane S, the JPHC Study. Cigarette smoking and subsequent risk of lung cancer by histologic type in middle-aged Japanese men and women: for the JPHC Study. Int J Cancer, 99:245-251, 2002
132. Murata M, Miyake T, Inoue Y, Ohshima S, Kudo S, Yoshimura T, Akiba S, Tango T, Yoshimoto Y, Shimizu Y, Sobue T, Kusumi S, Iwasaki T, Yamagishi C, Matsudaira H. Life-style and other characteristics of radiation workers at nuclear facilities in Japan: base-line data of a questionnaire survey. J Epidemiol, 12:310-319, 2002
133. Ando J, Ono Y, Yoshimura K, Onoda N, Shinohara M, Kanba S, Asai M. The genetic structure of cloninger's seven-factor model of temperament and character in a Japanese sample. J Pers, 70:583-609, 2002
134. Ono Y, Ando J, Onoda N, Yoshimura K, Momose T, Hirano M, Kanba S. Dimensions of temperament as vulnerability factors in depression. Mol Psychiatry, 7:948-953, 2002
135. Iwase T, Kajimura N, Uchiyama M, Ebisawa T, Yoshimura K, Kamei Y, Shibui K, Kim K, Kudo Y, Katoh M, Watanabe T, Nakajima T, Ozeki Y, Sugishita M, Hori T, Ikeda M, Toyoshima R, Inoue Y, Yamada N, Mishima K, Nomura M, Ozaki N, Okawa M, Takahashi K, Yamauchi T. Mutation screening of the human Clock gene in circadian rhythm sleep disorders. Psychiatry Res, 109:121-128, 2002
136. Yokoyama A, Watanabe H, Fukuda H, Haneda T, Kato H, Yokoyama T, Muramatsu T, Igaki H, Tachimori Y. Multiple cancers associated with esophageal and oropharyngolaryngeal squamous cell carcinoma and the aldehyde dehydrogenase-2 genotype in male Japanese drinkers. Cancer Epidemiol Biomarkers Prev, 11:895-900, 2002
137. Sobue T, Moriyama N, Kaneko M, Kusumoto M, Kobayashi T, Tsuchiya R, Kakinuma R, Ohmatsu H, Nagai K, Nishiyama H, Matsui E, Eguchi K. Screening for lung cancer with low-dose helical computed tomography: anti-lung cancer association project. J Clin Oncol, 20:911-920, 2002
138. Noda K, Nishiwaki Y, Kawahara M, Negoro S, Sugiura T, Yokoyama A, Fukuoka M, Mori K, Watanabe K, Tamura T, Yamamoto S, Saijo N, the Japan Clinical Oncology Group. Irinotecan plus cisplatin compared with etoposide plus cisplatin for extensive small-cell lung cancer. N Engl J Med, 346:85-91, 2002
139. Takada M, Fukuoka M, Kawahara M, Sugiura T, Yokoyama A, Yokota S, Nishiwaki Y, Watanabe K, Noda K, Tamura T, Fukuda H, Saijo N. Phase III study of concurrent versus sequential thoracic radiotherapy in combination with cisplatin and etoposide for limited-stage small-cell lung cancer: results of the Japan Clinical Oncology Group Study 9104. J Clin Oncol, 20:3054-3060, 2002
140. Hayashi K, Ando N, Watanabe H, Ide H, Nagai N, Aoyama N, Takiyama W, Ishida K, Isono K, Makuuchi H, Imamura M, Shinoda M, Ikeuchi S, Kabuto T, Yamana H, Fukuda H. Phase II evaluation of protracted infusion of cisplatin and 5-fluorouracil in advanced squamous cell carcinoma of the esophagus: a Japan Esophageal Oncology Group (JEOG) Trial (JCOG9407). Jpn J Clin Oncol, 31:419-423, 2001
141. Ikeda N, Shimada Y, Ohtsu A, Boku N, Tsuji Y, Saito H, Koizumi W, Iwase H, Yoshida S, Fukuda H. A Phase II Study of doxifluridine in elderly patients with advanced gastric cancer: the Japan Clinical Oncology Group Study (JCOG9410). Jpn J Clin Oncol, 32:90-94, 2002
142. Sekine I, Nishiwaki Y, Ogino T, Yokoyama A, Saito M, Mori K, Tsukiyama I, Tsuchiya S, Hayakawa K, Yoshimura K, Ishizuka N, Saijo N. Phase II study of twice-daily high-dose thoracic radiotherapy alternating with cisplatin and vindesine for unresectable stage III non-small-cell lung cancer: Japan Clinical Oncology Group Study 9306. J Clin Oncol, 20:797-803, 2002
143. Itoh K, Ohtsu T, Fukuda H, Sasaki Y, Ogura M, Morishima Y, Chou T, Aikawa K, Uike N, Mizorogi F, Ohno T, Ikeda S, Sai T, Taniwaki M, Kawano F, Niimi M, Hotta T, Shimoyama M, Tobinai K. Randomized phase II study of biweekly CHOP and dose-escalated CHOP with prophylactic use of lenograstim (glycosylated G-CSF) in aggressive non-Hodgkin's lymphoma: Japan Clinical Oncology Group Study 9505. Annals of Oncology, 13:1347-1355, 2002
144. Yamada Y, Tomonaga M, Fukuda H, Hanada S, Utsunomiya A, Tara M, Sano M, Ikeda S, Takatsuki K, Kozuru M, Araki K, Kawano F, Niimi M, Tobinai K, Hotta T, Shimoyama M, the Lymphoma Study Group of the Japan Clinical Oncology Group. A new G-CSF-supported combination chemotherapy, LSG15, for adult T-cell leukaemia-lymphoma : Japan Clinical Oncology Group Study 9303. Bri J Haematology, 113:375-382, 2001
145. Sano T, Yamamoto S, Sasako M, the Gastric Cancer Surgical Study Group of Japan Clinical Oncology Group. Randomized controlled trial to evaluate splenectomy in total gastrectomy for proximal gastric carcinoma: Japan Clinical Oncology Group Study JCOG 0110-MF. Jpn J Clin Oncol, 32:363-364, 2002
146. Niimi M, Yamamoto S, Fukuda H, Ishizuka N, Akaza H. The influence of handling censored date on estimating progression-free survival in cancer clinical trials (JCOG9913-A). Jpn J Clin Oncol, 32:19-26, 2002
147. Ishizuka N, Ohashi Y. The continual reassessment method and its applications : a Bayesian methodology for phase I cancer clinical trials. Statist Med, 20:2661-2681, 2001
148. Okada S, Tanaka K, Sato T, Ueno H, Saito S, Okusaka T, Sato K, Yamamoto S, Kakizoe T. Dose-response trial of lactoferrin in patients with Chronic hepatitis C. Jpn J Cancer Res, 93:1063-1069, 2002
149. Shigeeda T, Tomidokoro A, Araie M, Koseki N, Yamamoto S. Long-term follow-up of visual field progression after trabeculectomy in progressive normal-tension glaucoma. Ophthalmology, 109:766-770, 2002
150. Ikeda M, Okada S, Yamamoto S, Sato T, Ueno H, Okusaka T, Kuriyama H, Takayasu K, Furukawa H, Iwata R. Prognostic factors in patients with hepatocellular carcinoma treated by transcatheter arterial embolization. Jpn J Clin Oncol, 32:455-460, 2002
10. Virology Division

151. Sugiyama Y, Sugiyama K, Hirai Y, Akiyama F, Hasumi K. Microdissection is essential for gene expression profiling of clinically resected cancer tissues. Am J Clin Pathol, 117:109-116, 2002
152. Kishine H, Sugiyama K, Hijikata M, Kato N, Takahashi H, Noshi T, Nio Y, Hosaka M, Miyanari Y, Shimotohno K. Subgenomic replicon derived from a cell line infected with the hepatitis C virus. Biochem Biophys Res Commun, 293:993-999, 2002
11. Genetics Division

153. Ishizuka T, Tanabe C, Sakamoto H, Aoyagi K, Maekawa M, Matsukura N, Tokunaga A, Tajiri T, Yoshida T, Terada M, Sasaki H. Gene amplification profiling of esophageal squamous cell carcinomas by DNA array CGH. Biochem Biophys Res Commun, 296:152-155, 2002
154. Nezu M, Nishigaki M. Ishizuka T, Kuwahara Y, Tanabe C, Aoyagi K, Sakamoto H, Saito Y, Yoshida T, Sasaki H, Terada M. Identification of the CAB2/hCOS16 gene required for the repair of DNA double-strand breaks on a core amplified region of the 17q12 locus in breast and gastric cancers. Jpn J Cancer Res, 93:1183-1186, 2002
155. Katoh M. GIPC gene family (Review). Int J Mol Med, 9:585-589, 2002
156. Katoh M. WNT3-WNT14B and WNT3A-WNT14 gene clusters (Review). Int J Mol Med, 9:579-584, 2002
157. Katoh M. Strabismus (STB)/Vang-like (VANGL) gene family (Review). Int J Mol Med, 10:11-15, 2002
158. Kirikoshi H, Katoh M. Molecular cloning and characterization of human GIPC2, a novel gene homologous to human GIPC1 and Xenopus Kermit. Int J Oncol, 20:571-576, 2002
159. Kirikoshi H, Katoh M. Molecular cloning and characterization of mouse Wnt14b, clustered with mouse Wnt3 in mouse chromosome 11. Int J Mol Med, 9:135-139, 2002
160. Katoh M. Molecular cloning and expression of mouse Wnt14, and structual comparison between mouse Wnt14-Wnt3a gene cluster and human WNT14-WNT3A gene cluster. Int J Mol Med, 9:221-227, 2002
161. Saitoh T, Mine T, Katoh M. Molecular cloning and characterization of human GIPC3, a novel gene homologous to human GIPC1 and GIPC2. Int J Oncol, 20:577-582, 2002
162. Saitoh T, Mine T, Katoh M. Molecular cloning and characterization of mouse Gipc3. Int J Mol Med, 9:251-256, 2002
163. Katoh M. Molecular cloning and characterization of human SOX17. Int J Mol Med, 9:153-157, 2002
164. Saitoh T, Mine T, Katoh M. Up-regulation of WNT8B mRNA in human gastric cancer. Int J Oncol, 20:343-348, 2002
165. Katoh M. Molecular cloning and characterization of Strabismus 2 (STB2). Int J Oncol, 20:993-998, 2002
166. Katoh M. Molecular cloning and characterization of WRCH2 on human chromosome 15q15. Int J Oncol, 20:977-982, 2002
167. Saitoh T, Katoh M. Expression of human SOX18 in normal tissues and tumors. Int J Mol Med, 10:339-344, 2002
168. Kirikoshi H, Katoh M. Expression and regulaion of WNT10B in human cancer: up-regulation of WNT10B in MCF-7 cells by b-estradiol and down-regulation of WNT10B in NT2 cells by retinoic acid. Int J Mol Med, 10:507-511, 2002
169. Kirikoshi H, Katoh M. Expression of WNT7A in human normal tissues and cancer, and regulation of WNT7A and WNT7B in human cancer. Int J Oncol, 21:895-900, 2002
170. Saitoh T, Mine T, Katoh M. Up-regulation of Frizzled-10 (FZD10) by b-estradiol in MCF-7 cells and by retinoic acid in NT2 cells. Int J Oncol, 20:117-120, 2002
171. Katoh M. Regulation of WNT3 and WNT3A mRNAs in human cancer cell lines NT2, MCF-7, and MKN45. Int J Oncol, 20:373-377, 2002
172. Kirikoshi H, Katoh M. Expression of WRCH1 in human cancer and down-regulation of WRCH1 by b-estradiol in MCF-7 cells. Int J Oncol, 20:777-783, 2002
173. Katoh M. Expression of human SOX7 in normal tissues and tumors. Int J Mol Med, 9:363-368, 2002
174. Saitoh T, Mine T, Katoh M. Molecular cloning and expression of proto-oncogene FRAT1 in human cancer. Int J Oncol, 20:785-789, 2002
175. Kirikoshi H, Katoh M. Expression of human GIPC1 in normal tissues, cancer cell lines, and primary tumors. Int J Mol Med, 9:509-513, 2002
176. Saitoh T, Mine T, Katoh M. Expression and regulation of WNT8A and WNT8B mRNAs in human tumor cell lines: up-regulation of WNT8B mRNA by b-estradiol in MCF-7 cells, and down-regulation of WNT8A and WNT8B mRNAs by retinoic acid in NT2 cells. Int J Oncol, 20:999-1003, 2002
177. Katoh M. Structure and expression of Strabismus 1 gene on human chromosome 1q21-q23. Int J Oncol, 20:1197-1203, 2002
178. Kirikoshi H, Katoh M. Up-regulation of GIPC2 in human gastric cancer. Int J Oncol, 20:1183-1187, 2002
179. Katoh M. Paradigm shift in gene-finding method: from bench-top approach to desk-top approach. Int J Mol Med, 10:677-682, 2002
180. Katoh M. Genome-wide search of human genes implicated in WNT signaling pathway using bioinformatics. Genome Inform, 13:367-368, 2002
181. Katoh M. WNT and FGF gene clusters. Int J Oncol, 21:1269-1273, 2002
182. Katoh M. Regulation of WNT signaling molecules by retinoic acid during neuronal differentiation in NT2 cells: threshold model of WNT action. Int J Mol Med, 10:683-687, 2002
183. Saitoh T, Katoh M. Expression and regulation of WNT5A and WNT5B in human cancer: up-regulation of WNT5A by TNFa in MKN45 cells and up-regulation of WNT5B by b-estradiol in MCF-7 cells. Int J Mol Med, 10:345-349, 2002
184. Saitoh T, Mine T, Katoh M. Frequent up-regulation of WNT5A mRNA in primary gastric cancer. Int J Mol Med, 9:515-519, 2002
185. Spiegelman VS, Tang W, Chan AM, Igarashi M, Aaronson SA, Sassoon DA, Katoh M, Slaga TJ, Fuchs SY. Induction of homologue of slimb ubiquitin ligase receptor by mitogen signaling. J Biol Chem, 277:36624-36630, 2002
186. Spiegelman VS, Tang W, Katoh M, Slaga TJ, Fuchs SY. Inhibition of HOS expression and activities by Wnt pathway. Oncogene, 21:856-860, 2002
187. Terasaki H, Saitoh T, Shiokawa K, Katoh M. Frizzled-10, up-regulated in primary colorectal cancer, is a positive regulator of the WNT-b-catenin-TCF signaling path-way. Int J Mol Med, 9:107-112, 2002
188. Katoh M. Molecular cloning and characterization of human WINS1 and mouse Wins2, homologous to Drosophila segment polarity gene Lines (Lin). Int J Mol Med, 10:155-159, 2002
189. Katoh M. Molecular cloning and characterization of OSR1 on human chromosome 2p24. Int J Mol Med, 10:221-225, 2002
190. Katoh M. Molecular cloning and characterization of ST7R (ST7-like, ST7L) on human chromosome 1p13, a novel gene homologous to tumor suppressor gene ST7 on hu-man chromosome 7q31. Int J Oncol, 20:1247-1253, 2002
191. Kirikoshi H, Katoh M. Expression of ST7R (ST7-like, ST7L) in normal tissues and cancer. Int J Oncol, 21:193-196, 2002
192. Saitoh T, Katoh M. Molecular cloning and characterization of mouse St7r (St7-like, St7l). Int J Mol Med, 10:119-123, 2002
193. Kirikoshi H, Katoh M. Expression of TFF1, TFF2 and TFF3 in gastric cancer. Int J Oncol, 21:655-659, 2002
194. Furukawa-Hibi Y, Yoshida-Araki K, Ohta T, Ikeda K, Motoyama N. FOXO forkhead transcription factors induce G₂ -M checkpoint in response to oxidative stress. J Biol Chem, 277:26729-26732, 2002
195. Tachibana M, Sugimoto K, Nozaki M, Ueda J, Ohta T, Ohki M, Fukuda M, Takeda N, Niida H, Kato H, Shinkai Y. G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis. Genes Dev, 16:1779-1791, 2002
196. Kuroda Y, Oma Y, Nishimori K, Ohta T, Harata M. Brain-specific expression of the nuclear actin-related protein ArpNa and its involvement in mammalian SWI/SNF chromatin remodeling complex. Biochem Biophys Res Commun, 299:328-34 2002
197. Inoue A, Hayashi S, Aoyagi K, Nishigaki M, Sasaki H, Kiyama R. A reporter gene assay for evaluation of tissue-specific responses to estrogens based on the differential use of promoters A to F of human estrogen receptor a gene. J Pharmacol Toxicol Methods, 47:129-135, 2002
198. Nagata H, Mizushima H, Tanaka H. Concept and prototype of protein-ligand docking simulator with force feedback technology. Bioinformatics, 18:140-146, 2002
12. Radiobiology Division

199. Hofmann TG, Moller A, Sirma H, Zentgraf H, Taya Y, Droge W, Will H, Schmitz LM. Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2. Nat Cell Biol, 4:1-10, 2002
200. Matsuda K, Yoshida K, Taya Y, Nakamura K, Nakamura Y, Arakawa H. p53AIP1 regulates the mitochondrial apoptotic pathway. Cancer Res, 62:2883-2889, 2002
201. Okamoto K, Li H, Jensen MR, Zhang T, Taya Y, Thorgeirsson SS, Prives C. Cyclin G recruits PP2A to dephosphorylate Mdm2. Mol Cell, 9:761-771, 2002
202. Gottlieb TM, Leal JF, Seger R, Taya Y, Oren M. Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis. Oncogene, 21:1299-1303, 2002
203. Goldberg Z, Sinov VR, Berger M, Zwang Y, Perets R, Van ER, Oren M, Taya Y, Haupt Y. Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation. EMBO J, 21:3715-3727, 2002
204. Tanaka K, Terasaki T. Immunocytochemical expression of microtubule-associated protein-2(MAP-2) in small cell lung cancer cell lines with neuronal-like processes. Jpn J Cancer Res, 93:699-705, 2002
13. Carcinogenesis Division

205. Kaneda A, Kaminishi M, Nakanishi Y, Sugimura T, Ushijima T. Reduced expression of the insulin-induced protein 1 and p41 ARP2/3 complex genes in human gastric cancers. Int J Cancer, 100:57-62, 2002
206. Kaneda A, Kaminishi M, Yanagihara K, Sugimura T, Ushijima T. Identification of silencing of nine genes in human gastric cancers. Cancer Res, 62: 6645-6650, 2002
207. Miyamoto K, Fukutomi T, Asada K, Wakazono K, Tsuda H, Asahara T, Sugimura T, Ushijima T. Promoter hypermethylation and post-transcriptional mechanisms for reduced BRCA1 immunoreactivity in sporadic human breast cancers. Jpn J Clin Oncol, 32:79-84, 2002
208. Okochi E, Miyamoto K, Wakazono K, Shima H, Sugimura T, Ushijima T. Reduced Brca1 protein expression in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine induced rat mammary carcinomas. Mol Carcinog, 34:211-218, 2002
209. Abe M, Okochi E, Kuramoto T, Kaneda A, Takato T, Sugimura T, Ushijima T. Cloning of the 5' upstream region of the rat p16 gene and its role in silencing. Jpn J Cancer Res, 93:1100-1106, 2002
210. Yamashita S, Wakazono K, Sugimura T, Ushijima T. Profiling and selection of genes differentially expressed in the pylorus of rat strains with different proliferative responses and stomach cancer susceptibility. Carcinogenesis, 23:923-928, 2002
211. Yamashita S, Furumoto K, Nobukiyo A, Kamohara M, Ushijima T, Furukawa T. Mapping of a gene responsible for cataract formation and its modifier in the UPL rat. Invest Ophthalmol Vis Sci, 43:3153-3159, 2002
212. Kuwamura M, Maeda M, Kuramoto T, Kitada K, Kanehara T, Moriyama M, Nakane Y, Yamate J, Ushijima T, Kotani T, Serikawa T. The myelin vacuolation (mv) rat with a null mutation in the attractin gene. Lab Invest, 82:1279-1286, 2002
213. Kuramoto T, Nomoto T, Fujiwara A, Mizutani M, Sugimura T, Ushijima T. Insertional mutation of the attractin gene in the black tremor hamster. Mamm Genome, 13:36-40, 2002
214. Kuramoto T, Morimura K, Yamashita S, Okochi E, Watanabe N, Ohta T, Ohki M, Fukushima S, Sugimura T, Ushijima T. Etiology-specific gene expression profiles in rat mammary carcinomas. Cancer Res, 62:3592-3597, 2002
215. Okochi E, Watanabe N, Sugimura T, Ushijima T. Single nucleotide instability: a wide involvement in human and rat mammary carcinogenesis? Mutat Res, 506-507: 101, 2002
216. Okochi E, Ichimura S, Sugimura T, Ushijima T. The absence of Mth1 inactivation and DNA polymerase K overexpression in rat mammary carcinomas with frequent A:T to C:G transversions. Jpn J Cancer Res, 93:501-506, 2002
217. Li Q-L, Ito K, Sakakura C, Fukamachi H, Inoue K, Chi X-Z, Lee K-Y, Nomura S, Lee C-W, Han S-B, Kim H-M, Kim W-J, Yamamoto H, Yamashita N, Yano T, Ikeda T, Itohara S, Inazawa J, Abe T, Hagiwara A, Yamagishi H, Ooe A, Kaneda A, Sugimura T, Ushijima T, Bae S-C, Ito Y. Casual relationship between the loss of RUNX3 expres-sion and gastric cancer. Cell, 109:113-124, 2002
218. Takahashi S, Suzuki S, Inaguma S, Ikeda Y, Cho Y-m, Nishiyama N, Fujita T, Inoue T, Hioki T, Sugimura Y, Ushijima T, Shirai T. Down-regulation of human X-box binding protein 1 (hXBP-1) expression correlates with tumor progression in human prostate cancers. Prostate, 50:154-161, 2002
219. Takahashi S, Suzuki S, Inaguma S, Cho Y-M, Ikeda Y, Hayashi N, Inoue T, Sugimura Y, Nishiyama N, Fujita T, Ushijima T, Shirai T. Down-regulation of Lsml is involved in human prostate cancer progression. Br J Cancer, 86:940-946, 2002
14. Section for Studies on Metastasis

220. Yamamoto H, Ochiya T, Tamamushi S, Toriyama-Baba H, Takahama Y, Hirai K, Sasaki H, Sakamoto H, Saito I, Iwamoto T, Kakizoe T, Terada M. HST-1/FGF-4 gene activation induces spermatogenesis and prevents adriamycin-induced testicular toxicity. Oncogene, 21:899-908, 2002
221. Yamamoto H, Ochiya T, Takeshita F, Toriyama-Baba H, Hirai K, Sasaki H, Sasaki H, Sakamoto H, Yoshida T, Saito I, Terada M. Enhanced skin carcinogenesis in Cyclin D1-conditional transgenic mice: Cyclin D1 alters keratinocyte response to calcium-induced terminal differentiation. Cancer Res, 62:1641-1647, 2002
222. Hiroi N, Ito T, Yamamoto H, Ochiya T, Jinno S, Okayama H. Mammalian Rcd1 is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation. EMBO J, 21:5235-5244, 2002
16. Cancer Genomics Project

223. Kondoh K, Nakata Y, Furuta T, Hosoda F, Gamou T, Kurosawa Y, Kinoshita A, Ohki M, Tomita Y, Mori T. A pediatric case of secondary leukemia associated with t(16;21)(q24;q22) exhibiting the chimeric AML1-MTG16 gene. Leuk Lymphoma, 43:415-420, 2002
17. Cancer Prevention Basic Research Project

224. Watanabe T, Takahashi Y, Takahashi T, Nukaya H, Terao Y, Hirayama T, Wakabayashi K. Seasonal fluctuation of the mutagenicity of river water in Fukui, Japan, and the contribution of 2-phenylbenzotriazole-type mutagens. Mutat Res, 519:187-197, 2002
225. Watanabe T, Shiozawa T, Takahashi Y, Takahashi T, Terao Y, Nukaya H, Takamura T, Sawanishi H, Ohe T, Hirayama T, Wakabayashi K. Mutagenicity of two 2-phenylbenzotriazole derivatives, 2-[2-(acetylamino)-4-(diethylamino)-5-methoxy phe-nyl]- 5-amino -7-bromo-4-chloro-2H-benzotriazole and 2-[2-(acetylamino)-4-(diallylamino)-5-methoxyphenyl] -5-amino-7-bromo-4-chloro-2H-benzotriazole and their detection in river water in Japan. Mutagenesis, 17:293-299, 2002
226. Takamura-Enya T, Watanabe T, Tada A, Hirayama T, Nukaya H, Sugimura T, Wakabayashi K. Identification of a new mutagenic polychlorinated biphenyl deriva-tive in the Waka River, Wakayama, Japan, showing activation of an aryl hydrocar-bon receptor-dependent transcription. Chem Res Toxicol, 15:419-425, 2002
227. Totsuka Y, Takamura-Enya T, Kawahara N, Nishigaki R, Sugimura T, Wakabayashi K. Structure of DNA adduct formed with aminophenylnorharman, being responsible for the comutagenic action of norharman with aniline. Chem Res Toxicol, 15:1288-1294, 2002
228. Totsuka Y, Kataoka H, Takamura-Enya T, Sugimura T, Wakabayashi K. In vitro and in vivo formation of aminophenylnorharman from norharman and aniline. Mut Res, 506-507:49-54, 2002
229. Ohe T, Takata T, Maeda Y, Totsuka Y, Hada N, Matsuoka A, Tanaka N, Wakabayashi K. Induction of sister chromatid exchanges and chromosome aberrations in cultured mammalian cells treated with aminophenylnorharman formed by norharman with aniline. Mutat Res, 515:181-188, 2002
230. Nagao T, Yoshimura S, Totsuka Y, Wakabayashi K. Maternal and developmental toxicity in mice by aminophenylnorharman, formed from norharman and aniline. Human Exp Toxicol, 21:147-151, 2002
231. Shibata H, Ohta T, Iimuro M, Kitamura T, Yokokura T, Wakabayashi K. Suppression of Helicobacter pylori-induced gastritis by urease inhibitors in Mongolian gerbils. Jpn J Cancer Chemother, 29:154-158, 2002
232. Iimuro M, Shibata H, Kawamori T, Matsumoto T, Arakawa T, Sugimura T, Wakabayashi K. Suppressive effects of garlic extract on Helicobacter pylori-induced gastritis in Mongolian gerbils. Cancer Lett, 187:61-68, 2002
233. Mutoh M, Watanabe K, Kitamura T, Shoji Y, Takahashi M, Kawamori T, Tani K, Kobayashi M, Maruyama T, Kobayashi K, Ohuchida S, Sugimoto Y, Narumiya S, Sugimura T, Wakabayashi K. Involvement of prostaglandin E receptor subtype EP₄ in colon carcinogenesis. Cancer Res, 62:28-32, 2002
234. Kawamori T, Uchiya N, Kitamura T, Ohuchida S, Yamamoto H, Maruyama T, Sugimura T, Wakabayashi K. Evaluation of a selective prostaglandin E receptor EP₁ antagonist for potential properties in colon carcinogenesis. Anticancer Res, 21:3865-3870, 2001
235. Kawamori T, Wakabayashi K. COX-2 and prostanoid receptors: good targets for chemoprevention. J Environ Pathol Toxicol Oncol, 21:149-153, 2002
236. Kitamura T, Kawamori T, Uchiya N, Itoh M, Noda T, Matsuura M, Sugimura T, Wakabayashi K. Inhibitory effects of mofezolac, a cyclooxygenase-1 selective inhibitor, on intestinal carcinogenesis. Carcinogenesis, 23:1463-1466, 2002
237. Kawamori T, Nakatsugi S, Ohta T, Sugimura T, Wakabayashi K. Chemopreventive effects of nimesulide, a selective cyclooxygenase-2 inhibitor, against PhIP-induced mammary carcinogenesis. In: Honn KV (ed), Kluwer Academic/Plenum Publishers. Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5, pp. 371-376, 2002
238. Sasahara Y, Mutoh M, Takahashi M, Fukuda K, Tanaka N, Sugimura T, Wakabayashi K. Suppression of promoter-dependent transcriptional activity of inducible nitric oxide synthase by sodium butyrate in colon cancer cells. Cancer Lett, 177:155-161, 2002
239. Hosoda A, Ozaki Y, Kashiwada A, Mutoh M, Wakabayashi K, Mizuno K, Nomura E, Taniguchi H. Syntheses of ferulic acid derivatives and their suppressive effects on cyclooxygenase-2 promoter activity. Bioorganic & Medicinal Chemistry, 10:1189-1196, 2002
240. Kanazawa T, Kono T, Watanabe M, Matsushima- Hibiya Y, Nakano T, Koyama K, Tanaka N, Sugimura T, Wakabayashi K. Bcl-2 blocks apoptosis caused by pierisin-1, a guanine-specific ADP-ribosylating toxin from the cabbage butterfly. Biochem Biophys Res Commun, 296:20-25, 2002
241. Kanazawa T, Watanabe M, Kanzawa F, Matsushima-Hibiya Y, Koyama K, Tanaka N, Sugimura T, Wakabayashi K. Pierisin-1 from cabbage butterfly suppresses HeLa tumor growth in nude mice. Proc Jpn Acad, 78B:305-308, 2002
19. DNA Methylation and Genome Function Project

242. Shiraishi M, Sekiguchi A, Oates A, Terry M, Miyamoto Y, Sekiya T. Heterogeneity in the methylation status of genomic DNA fragments demonstrating similar elution profiles in methyl-CpG binding domain column chromatography. Proc Japan Acad, 77(B):208-211, 2001
243. Shiraishi M, Oates AJ, Sekiya T. An overview of the analysis of DNA methylation in mammalian genomes. Biol Chem, 383:893-906, 2002
244. Shiraishi M, Sekiguchi A, Oates AJ, Terry MJ, Miyamoto Y, Tanaka K, Sekiya T. Variable estimation of genomic DNA methylation: a comparison of methyl-CpG binding domain column chromatography and bisulfite genomic sequencing. Anal Biochem, 308:182-185, 2002
245. Shiraishi M, Sekiguchi A, Terry MJ, Oates AJ, Miyamoto Y, Chuu YH, Munakata M, Sekiya T. A comprehensive catalog of CpG islands methylated in human lung adenocarcinomas for the identification of tumor suppressor genes. Oncogene, 21:3804-3813, 2002
246. Shiraishi M, Sekiguchi A, Oates AJ, Terry MJ, Miyamoto Y. HOX gene clusters are hotspots of de novo methylation in CpG islands of human lung adenocarcinomas. Oncogene, 21:3659-3662, 2002
247. Koizume S, Tachibana K, Sekiya T, Hirohashi S, Shiraishi M. Heterogeneity in the modification and involvement of chromatin components of the CpG island of the silenced human CDH1 gene in cancer cells. Nucleic Acids Res, 30:4770-4780, 2002
20. Tumor Endocrinology Project

248. Yaguchi H, Ohkura N, Tsukada T, Yamaguchi K. Menin, the multiple endocrine neo-plasia type 1 gene product, exhibits GTP-hydrolyzing activity in the presence of the tumor metastasis suppressor nm23. J Biol Chem, 277:38197-38204, 2002
249. Nagase T, Murakami T, Tsukada T, Kitamura R, Chikatsu N, Takeo H, Takata N, Yasuda H, Fukumoto S, Tanaka Y, Nagata N, Yamaguchi K, Akatsu T, Yamamoto M. A family of autosomal dominant hypocalcemia with a positive correlation between serum calcium and magnesium: identification of a novel gain of function mutation (Ser820Phe) in the calcium-sensing receptor. J Clin Endocrinol Metab, 87:2681-2687, 2002
250. Ohkubo T, Sugawara Y, Sasaki K, Maruyama K, Ohkura N, Makuuchi M. Early induction of nerve growth factor-induced genes after liver resection-reperfusion injury. J Hepatol, 36:210-217, 2002
251. Inuzuka H, Tokumitsu H, Ohkura N, Kobayashi R. Transcriptional regulation of nuclear orphan receptor, NOR-1, by Ca²⁺ /calmodulin-dependent protein kinase cascade. FEBS Lett, 522:88-92, 2002
252. Ohkura N, Yaguchi H, Tsukada T, Yamaguchi K. The EWS/NOR1 fusion gene product gains a novel activity affecting pre-mRNA splicing. J Biol Chem, 277:535-543, 2002
253. Nara-Ashizawa N, Tsukada T, Maruyama K, Akiyama Y, Kajimura N, Yamaguchi K. Response of hypothalamic NPY mRNAs to a negative energy balance is less sensitive in cachectic mice bearing human tumor cells. Nutr Cancer, 41:111-118, 2001
254. Onoue, S. K. Ohshima, K. Endo, T. Yajima, and K. Kashimoto. PACAP protects neuronal PC12 cells from the cytotoxicity of human prion protein fragment 106-126. FEBS Lett, 522: 65-70, 2002
255. Onoue, S., K. Endo, K. Ohshima, T. Yajima, and K. Kashimoto. The neuropeptide PACAP attenuates b-amyloid(1-42)-induced toxicity in PC12 cells. Peptides, 23: 1471-1478, 2002
21. Tumor Suppression and Functional Genomics Project

256. Fukuhara H, Kuramochi M, Fukami T, Kasahara K, Furuhata M, Nobukuni T, Maruyama T, Isogai K, Sekiya T, Shuin T, Kitamura T, Reeves RH, Murakami Y. Promoter methylation of TSLC1 and tumor suppression by its gene product in hu-man prostate cancer. Jpn J Cancer Res, 93:605-609, 2002
257. Murakami Y. Functional cloning of a tumor suppressor gene, TSLC1, in human non-small cell lung cancer. Oncogene, 21:6936-6948, 2002
258. Honda T, Tamura G, Waki T, Jin Z, Sato K, Motoyama T, Kawata S, Kimura W, Nishizuka S, Murakami Y. Hypermethylation of the TSLC1 gene promoter in primary gastric cancers and gastric cancer cell lines. Jpn J Cancer Res, 93:857-860, 2002
259. Yageta M, Kuramochi M, Masuda M, Fukami T, Fukuhara H, Maruyama T, Shibuya T, Murakami Y. Direct association of TSLC1 and DAL-1, two distinct tumor suppressor proteins in lung cancer. Cancer Res, 62:5129-5133, 2002
260. Masuda M, Yageta M, Fukuhara H, Kuramochi M, Maruyama T, Nomoto A, Murakami Y. The tumor suppressor protein TSLC1 is involved in cell-cell adhesion. J Biol Chem, 277:31014-31019, 2002
261. Fukami T, Satoh H, Maruyama T, Fukuhara H, Kuramochi M, Takamoto S, Momoi T, Murakami Y. Identification of the Tslc1 gene, a mouse orthologue of the human tumor suppressor TSLC1 gene. Gene, 295:7-12, 2002
262. Tamura K, Miwa W, Maruyama T, Sekiya T, Murakami Y. Homozygous deletion on the chromosomal region 5q12.3 in human lines of small-cell lung cancers. J Hum Genet, 47:348-354, 2002
22. Pathology Division, East

263. Hasebe T, Sasaki S, Imoto S, Mukai K, Yokose T, Ochiai A. Prognostic significance of fibrotic focus in invasive ductal carcinoma of the breast: a prospective observational study. Mod Pathol, 15:502-516, 2002
264. Hasebe T, Sasaki S, Imoto S, Ochiai A. Characteristics of tumors in lymph vessels play an important role in the tumor progression of invasive ductal carcinoma of the breast: a prospective study. Mod Pathol, 15:904-913, 2002
265. Kawahira H, Hasebe T, Kinoshita T, Sasaki S, Konishi M, Nakagori T, Inoue K, Oda T, Takahashi S, Ochiai T, Ochiai A. The intraductal carcinoma component is a significant prognostic parameter in patients with invasive ductal carcinoma of the pancreas. Jpn J Cancer Res, 93:1138-1144, 2002
266. Takahashi S, Hasebe T, Oda T, Sasaki S, Kinoshita T, Konishi M, Ochiai T, Ochiai A. Cytoplasmic expression of laminin g2 chain correlates with postoperative hepatic metastasis and poor prognosis in patients with pancreatic ductal adenocarcinoma. Cancer, 94:1894-1901, 2002
267. Hironaka S, Hasebe T, Kamijo T, Ohtsu A, Boku N, Yoshida S, Saitoh H, Ochiai A. Biopsy specimen microvessel density is a useful prognostic marker in patients with T₂ - ₄M₀ esophageal cancer treated with chemoradiotherapy. Clin Cancer Res, 8:124-130, 2002
268. Ueda T, Oda T, Kinoshita T, Konishi M, Nakahashi C, Takahashi S, Hasebe T, Fukao K, Ochiai A. Neovascularization in pancreatic ductal adenocarcinoma: microvessel count analysis, comparison with non-cancerous regions and other types of carcinomas. Oncol Rep, 9:239-245, 2002
269. Inagaki H, Chan JK, Ng JW, Okabe M, Yoshino T, Okamoto M, Ogawa H, Matsushita H, Yokose T, Matsuno Y, Nakamura N, Nagasaka T, Ueda R, Eimoto T, Nakamura S. Primary thymic extranodal marginal-zone B-cell lymphoma of mucosa-associated lymphoid tissue type exhibits distinctive clinicopathological and molecular features. Am J Pathol, 160:1435-1443, 2002
270. Hirose T, Kondo K, Takahashi Y, Ishikura H, Fujino H, Tsuyuguchi M, Hashimoto M, Yokose T, Mukai K, Kodama T, Monden Y. Frequent microsatellite instability in lung cancer from chromate-exposed workers. Mol Carcinog, 33:172-180, 2002
271. Abe T, Furuse J, Yoshino M, Kinoshita T, Konishi M, Inoue K, Hasebe T. Clinical characteristics of hepatocellular carcinoma with an extensive lymph node metastasis at diagnosis. Am J Clin Oncol, 25:318-323, 2002
272. Shimizu K, Nagai K, Yoshida J, Nishimura M, Hayashi R, Yokose T. Case report: successful management of solitary malar metastasis from lung cancer. Lung Cancer, 36:337-339, 2002
273. Fu K-I, Muto M, Mera K, Sano Y, Nagashima F, Tahara M, Boku N, Ohtsu A, Kanomata N, Ochiai A, Yoshida S. Carcinoma coexisting with esophageal leiomyoma: a case report. Gastrointest Endosc, 56:272-273, 2002
274. Tonooka T, Sano Y, Fujii T, Kato S, Yoshino T, Fu K-I, Hironaka S, Ochiai A, Yoshida S. Adenocarcinoma in solitary large hyperplastic polyp diagnosed by magnifying colonoscope. Dis Colon Rectum, 45:1407-1411, 2002
275. Nakajima R, Yokose T, Kakinuma R, Nagai K, Nishiwaki Y, Ochiai A. Localized pure ground-glass opacity on high-resolution CT: histologic characteristics. J Comput Assist Tomogr, 26:323-329, 2002
276. Kuroki Y, Nawano S, Hasebe T, Imoto S, Nasu K, Murakami K, Satake M, Sekiguchi R, Hayashi T. Efficacy of MR mammography (MRM) in providing preoperative locoregional information on breast cancer: correlation between MRM and histological findings. Magn Reson Med Sci, 1:73-80, 2002
277. Imoto S, Wada N, Hasebe T, Ochiai A, Ebihara S, Moriyama N. Sentinel node biopsy for breast cancer patients in Japan. Biomed Pharmacother, 56:192-195, 2002
23. Epidemiology and Biostatistics Division

278. Hara M, Sasaki S, Sobue T, Yamamoto S, Tsugane S. Comparison of cause-specific mortality between respondents and nonrespondents in a population-based prospective study: ten-year follow-up of JPHC Study Cohort I. J Clin Epidemiol, 55:150-156, 2002
279. Takashima Y, Yoshida M, Yoshinaga A, Sasaki S, Tsugane S, the JPHC Study Group. Usefulness of the recall-based self-report as a means of case definition in epidemiological studies on senile cataracts. Jpn J Health Human Ecology, 68:43-53, 2002
280. Kataoka H, Nishioka S, Kobayashi M, Hanaoka T, Tsugane S. Analysis of mutagenic heterocyclic amines in cooked food samples by gas chromatography with nitrogen-phosphorus detector. Bull Environ Contam Toxicol, 69:682-689, 2002
281. Kobayashi M, Hanaoka T, Nishioka S, Kataoka H, Tsugane S. Estimation of dietary HCA intakes in a large-scale population-based prospective study in Japan. Mut Res, 506-507:233-241, 2002
282. Hara M, Sobue T, Sasaki S, Tsugane S. Smoking and risk of premature death among middle-aged Japanese: ten-year follow-up of the Japan Public Health Center-based prospective study on cancer and cardiovascular diseases (JPHC Study) Cohort 1. Jpn J Cancer Res, 93:6-14, 2002
283. Sasazuki S, Sasaki S, Tsugane S, the JPHC Study Group. Cigarette smoking, alcohol consumption and subsequent gastric cancer risk by subsite and histologic type. Int J Cancer, 101:560-566, 2002
284. Hara M, Sasaki S, Tsugane S, the JPHC Study Group. Effect of smoking on the association between alcohol consumption and cancer mortality among middle-aged Japanese men: JPHC Study Cohort I. IARC Sci Publ, 156:165-168, 2002
285. Tsugane S, Sasaki S, Tsubono Y. Under- and overweight impact on mortality among middle-aged Japanese men and women: a 10-y follow-up of JPHC Study Cohort I. Int J Obes, 26:529-537, 2002
286. Kobayashi M, Tsubono Y, Sasazuki S, Sasaki S, Tsugane S, the JPHC Study Group. Vegetables, fruit and risk of gastric cancer in Japan: a 10-year follow-up of the JPHC Study Cohort I. Int J Cancer, 102:39-44, 2002
287. Kim MK, Sasaki S, Sasazuki S, Okubo S, Hayashi M, Tsugane S. Lack of long-term effect of vitamin C supplementation on blood pressure. Hypertension, 40:797-803, 2002
288. Hanaoka T, Nair J, Takahashi Y, Sasaki S, Bartsch H, Tsugane S. Urinary level of 1,N⁶-ethenodeoxyadenosine, a marker of oxidative stress, is associated with salt excretion and w6-polyunsaturated fatty acid intake in postmenopausal Japanese women. Int J Cancer, 100:71-75, 2002
289. Nishimoto IN, Hamada GS, Kowalski LP, Rodrigues JG, Iriya K, Sasazuki S, Hanaoka T, Tsugane S, the Sao Paulo-Japan Cancer Project Gastric Cancer Study Group. Risk factors for stomach cancer in Brazil (I): a case-control study among non-Japanese Brazilians in Sao Paulo. Jpn J Clin Oncol, 32:277-283, 2002
290. Hamada GS, Kowalski LP, Nishimoto IN, Rodrigues JJG, Iriya K, Sasazuki S, Hanaoka T, Tsugane S, the Sao Paulo-Japan Cancer Project Gastric Cancer Study Group. Risk factors for stomach cancer in Brazil (II): a case-control study among Japanese Brazilians in Sao Paulo. Jpn J Clin Oncol, 32:284-290, 2002
291. Yamamoto M, Lang I, Sakai H, Nakadaira H, Nakamura K, Tsuchiya Y, Tsugane S. Endocrine disrupting chemicals in Hungarian canned foods. Environ Health Preventive Med, 6:273-275, 2002
292. Hanaoka T, Takahashi Y, Kobayashi M, Sasaki S, Usuda M, Okubo S, Hayashi M, sugane S. Residuals of beta-hexachlorocyclohexane, dichlorodiphenyltrichloroethane, and hexachlorobenzene in serum, and relations with consumption of dietary components in rural residents in Japan. The science of the total environ, 286:119-127, 2002
293. Hanaoka T, Li Q, Imagawa J, Taguchi M, Minami M, Tsugane S. Occupational llergic dermatitis induced by an epoxy hardener alkylamine. J Occup Health Psychol, 44:264-266, 2002
294. Hanaoka T, Kawamura N, Hara K, Tsugane S. Urinary bisphenol A and plasma hormone concentrations in male workers exposed to bisphenol A diglycidyl ether and mixed organic solvents. Occup Environ Med, 59:625-628, 2002
295. Hanaoka T, Yamano Y, Pan G, Hara K, Ichiba M, Zhang J, Zhang S, Liu T, Li L, Takahashi K, Kagawa J, Tsugane S. Cytochrome P450 1B1 mRNA levels in peripheral blood cells and exposure to polycyclic aromatic hydrocarbons in Chinese coke oven workers. The Science of the Total Environ, 296:27-33, 2002
296. Hirabayashi N, Sakai T, Kiso T, Nobuto A, Yamashita Y, Isomoto A, Kojima K, Hanaoka T, Kimura T, Fukutake K. The development of a Japanese version of the HIV dementia scale to detect cognitive disorders in patients with HIV, and its sensitivity and specificity. J AIDS Res, 4:1-7, 2002
297. Hirabayashi N, Fukunishi I, Kojima K, Kiso T, Yamashita Y, Fukutake K, Hanaoka T, Iimori M. Psychosocial factors associated with quality of life in Japanese patients with human immunodeficiency virus infection. Psychosomatics, 43:16-23, 2002
24. Investigative Treatment Division

298. Tsukioka Y, Matsumura Y, Hamaguchi T, Koike H, Moriyasu F, Kakizoe T. Pharmaceutical and biomedical differences between micellar doxorubicin (NK911) and liposomal doxorubicin (Doxil). Jpn J Cancer Res, 93:1145-1153, 2002
299. Mizumura Y, Matsumura Y, Yokoyama M, Okano T, Kawaguchi T, Moriyasu F, Kakizoe T. Incorporation of the anticancer agent KRN5500 into polymeric micelles diminishes the pulmonary toxicity. Jpn J Cancer Res 93:1237-1243, 2002
300. Kimura H, Ogura T, Kurashima Y, Weisz A, Esumi H. Effects of nitric oxide donots on vascular endothelial growth factor gene induction. Biochem Biophys Res Commun, 296:976-982, 2002
301. Kato K, Ogura T, Kishimoto A, Minegishi Y, Nakajima N, Miyazaki M, Esumi H. Critical roles of AMP-activated protein kinase in constitutive tolerance of cells to nutrient deprivation and tumor formation. Oncogene, 21:6082-6090, 2002
302. Hashimoto K, Kato K, Imamura K, Kishimoto A, Yoshikawa H, Taketani Y, Esumi H. 5-Amino-4-imidazoecarboxamide riboside (AICAR) confers strong tolerance to glucose starvation in a 5'-AMP activated protein kinase dependent fashion. Biochem Biophys Res Commun, 290:263-267, 2002
303. Esumi H, Izuishi K, Kato K, Hashimoto K, Kurashima Y, Kishimoto A, Ogura T, Takayuki O. Hypoxia and nitric oxide treatment confer tolerance to glucose starvation in a 5'-AMP-activated protein kinase-dependent manner. J Biol Chem, 277:32791-32798, 2002
304. Kato K, Hitomi Y, Imamura K, Esumi H. Hyperstable U1snRNA complementary to the K-ras transcripts inducec cell death in pancreatic cancer cells. Br J Cancer, 87: 898-904, 2002
305. Hokari A, Zeniya M, Esumi H, Kawabe T, Gershwin ME, Toda G. Detection of serum nitrite and nitrate in primary biliary cirrhosis: possible role of nitric oxide in bile duct injury. J Gastroenterol Hepatol, 17:308-315, 2002
306. Muto M, Nakane M, Hitomi Y, Yoshida S, Sasaki S, Ohtsu A, Yoshida S, Ebihara S, Esumi H. Association between aldehyde dehydrogenase gene polymorphisms and the phenomenon of field cancerization in patients with head and neck caner. Carcinogenesis, 23:1759-1765, 2002
25. Psycho-Oncology Division

307. Nakanishi T, Nukariya K, Kasahara H, Ushijima S, Hirai K, Akechi T, Okamura H, Uchitomi Y. Psychological distress of family members with cancer patients in Japan. Int J Psychiatry Clin Pract, 6:205-210, 2002
308. Morita T, Akechi T, Sugawara Y, Chihara S, Uchitomi Y. Practices and attitudes of Japanese oncologist and palliative care physicians concerning terminal sedation: a nationwide survey. J Clin Oncol, 20:758-764, 2002
309. Nishida A, Hisaoka K, Zensho H, Uchitomi Y, Morinobu S, Yamawaki S. Antidepressant drugs and cytokines in mood disorders. Int Immunopharmacol, 2:1619-1626, 2002
310. Akizuki N, Okamura H, Akechi T, Nakano T, Yoshikawa E, Nakanishi T, Uchitomi Y. Clinical experience of the pharmacological treatment algorithm for major depression in advanced cancer patients: preliminary study. Int J Psychiatry Clin Pract, 6:83-89, 2002
311. Akechi T, Nakano T, Akizuki N, Nakanishi T, Yoshikawa E, Okamura H, Uchitomi Y. Clinical factors associated with suicidality in cancer patients. Jpn J Clin Oncol, 32:506-511, 2002
312. Uchitomi Y, Kugaya A, Akechi T, Nakano T, Inagaki M, Matsuoka Y, Kagaya A, Yamawaki S. Lack of association between suicidal ideation and enhanced platelet 5-HT2A receptor-mediated calcium mobilization in cancer patients with depression. Biol Psychiatry, 52:1159-1165, 2002
313. Akechi T, Okamura H, Nishiwaki Y, Uchitomi Y. Predictive factors for suicidal ideation in patients with unresectable lung carcinoma: a 6-month follow-up study. Cancer, 95:1085-1093, 2002
314. Matsuoka Y, Nakano T, Inagaki M, Sugawara Y, Akechi T, Imoto S, Murakami K, Yamawaki S, Uchitomi Y. Cancer-related intrusive thoughts as an indicator of poor psychological adjustment at 3 or more years after breast surgery: a preliminary study. Breast Cancer Res Treat, 76:117-124, 2002
315. Inagaki M, Akizuki N, Kugaya A, Fujii H, Akechi T, Uchitomi Y. Metyrapone for Cushing's syndrome. Am J Psychiatry, 159:1246, 2002
316. Nakano T, Wenner M, Inagaki M, Kugaya A, Akechi T, Matsuoka Y, Sugawara Y, Imoto S, Murakami K, Uchitomi Y. Relationship between distressing cancer-related recollections and hippocampal volume in cancer survivors. Am J Psychiatry, 159:2087-2093, 2002
317. Sugawara Y, Akechi T, Shima Y, Okuyama T, Akizuki N, Nakano T, Uchitomi Y. Efficacy of methylphenidate for fatigue in advanced cancer patients: a preliminary study. Palliat Med, 16:261-263, 2002
318. Tanaka K, Akechi T, Okuyama T, Nishiwaki Y, Uchitomi Y. Impact of dyspnea, pain, and fatigue on daily life activities in ambulatory patients with advanced lung cancer. J Pain Symptom Manage, 23:417-423, 2002
319. Tanaka K, Akechi T, Okuyama T, Nishiwaki Y, Uchitomi Y. Prevalence and screening of dyspnea interfering with daily life activities in ambulatory patients with advanced lung cancer. J Pain Symptom Manage, 23:484-489, 2002
320. Tanaka K, Akechi T, Okuyama T, Nishiwaki Y, Uchitomi Y. Factors correlated with dyspnea in advanced lung cancer patients: organic causes and what else? J Pain Symptom Manage, 23:490-500, 2002