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List of Papers Published in 2003

1. Pathology Division

1. Kanai Y, Ushijima S, Nakanishi Y, Sakamoto M, Hirohashi S. Mutation of the DNA methyltransferase (DNMT) 1 gene in human colorectal cancers. Cancer Lett, 192:75-82, 2003

2. Saito Y, Kanai Y, Nakagawa T, Sakamoto M, Saito H, Ishii H, Hirohashi S. Increased protein expression of DNA methyltransferase(DNMT)1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas. Int J Cancer, 105:527-532, 2003

3. Nakagawa T, Kanai Y, Saito Y, Kitamura T, Kakizoe T, Hirohashi S. Increased DNA methyltransferase 1 protein expression in human transitional cell carcinoma of the bladder. J Urol, 170:2463-2466, 2003

4. Horikawa Y, Sugano K, Shigyo M, Yamamoto H, Nakazono M, Fujimoto H, Kanai Y, Hirohashi S, Kakizoe T, Habuchi T, Kato T. Hypermethylation of an E-cadherin (CDH1) promoter region in high grade transitional cell carcinoma of the bladder comprising carcinoma in situ. J Urol, 169:1541-1545, 2003

5. Hirohashi S, Kanai Y. Cell adhesion system and human cancer morphogenesis. Cancer Sci, 94:575-581, 2003

6. Tsuiji H, Takasaki S, Sakamoto M, Irimura T, Hirohashi S. Aberrant O-glycosylation inhibits stable expression of dysadherin, a carcinoma-associated antigen, and facilitates cell-cell adhesion. Glycobiology, 13:521-527, 2003

7. Aoki S, Shimamura T, Shibata T, Nakanishi Y, Moriya Y, Sato Y, Kitajima M, Sakamoto M, Hirohashi S. Prognostic significance of dysadherin expression in advanced colorectal carcinoma. Br J Cancer, 88:726-732, 2003

8. Shimamura T, Sakamoto M, Ino Y, Sato Y, Shimada K, Kosuge T, Sekihara H, Hirohashi S. Dysadherin overexpression in pancreatic ductal adenocarcinoma reflects tumor aggressiveness: relationship to E-cadherin expression. J Clin Oncol, 21:659-667, 2003

9. Sato H, Ino Y, Miura A, Abe Y, Sakai H, Ito K, Hirohashi S. Dysadherin: expression and clinical significance in thyroid carcinoma. J Clin Endocrinol Metab, 88:4407-4412, 2003

10. Kanetaka K, Sakamoto M, Yamamoto Y, Takamura M, Kanematsu T, Hirohashi S. Possible involvement of tetraspanin CO-029 in hematogenous intrahepatic metastasis of liver cancer cells. J Gastroenterol Hepatol, 18:1309-1314, 2003

11. Chuma M, Sakamoto M, Yamazaki K, Ohta T, Ohki M, Asaka M, Hirohashi S. Expression profiling in multistage hepatocarcinogenesis: identification of HSP70 as a molecular marker of early hepatocellular carcinoma. Hepatology, 37:198-207, 2003

12. Yamamoto Y, Sakamoto M, Fujii G, Tsuiji H, Kanetaka K, Asaka M, Hirohashi S. Overexpression of orphan G-protein-coupled receptor, Gpr49, in human hepatocellular carcinomas with b-catenin mutations. Hepatology, 37:528-533, 2003

13. Yamazaki K, Sakamoto M, Ohta T, Kanai Y, Ohki M, Hirohashi S. Overexpression of KIT in chromophobe renal cell carcinoma. Oncogene, 22:847-852, 2003

14. Tsuchiya A, Sakamoto M, Yasuda J, Chuma M, Ohta T, Ohki M, Yasugi T, Taketani Y, Hirohashi S. Expression profiling in ovarian clear cell carcinoma: identification of hepatocyte nuclear factor-1b as a molecular marker and a possible molecular target for therapy of ovarian clear cell carcinoma. Am J Pathol, 163:2503-2512, 2003

15. Takamura M, Sakamoto M, Ino Y, Shimamura T, Ichida T, Asakura H, Hirohashi S. Expression of liver-intestine cadherin and its possible interaction with galectin-3 in ductal adenocarcinoma of the pancreas. Cancer Sci, 94:425-430, 2003

16. Yamada Y, Itano N, Narimatsu H, Kudo T, Hirohashi S, Ochiai A, Tohnai I, Ueda M, Kimata K. CD44 variant exon 6 expressions in colon cancer assessed by quantitative analysis using real time reverse transcriptase-polymerase chain reaction. Oncol Rep, 10:1919-1924, 2003

17. Shibata T, Chuma M, Kokubu A, Sakamoto M, Hirohashi S. EBP50, a b-catenin-associating protein, enhances Wnt signaling and is over-expressed in hepatocellular carcinoma. Hepatology, 38:178-186, 2003

18. Sekine S, Shibata T, Matsuno Y, Maeshima A, Ishii G, Sakamoto M, Hirohashi S. b-catenin mutations in pulmonary blastomas: association with morule formation. J Pathol, 200:214-221, 2003

19. Sekine S, Sato S, Takata T, Fukuda Y, Ishida T, Kishino M, Shibata T, Kanai Y, Hirohashi S. b-catenin mutations are frequent in calcifying odontogenic cysts, but rare in ameloblastomas. Am J Pathol, 163:1707-1712, 2003

20. Ishitani T, Kishida S, Hyodo-Miura J, Ueno N, Yasuda J, Waterman M, Shibuya H, Moon RT, Ninomiya-Tsuji J, Matsumoto K. The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca2+ pathway to antagonize Wnt/b-catenin signaling. Mol Cell Biol, 23:131-139, 2003

21. Sakaki M, Hirokawa M, Wakatsuki S, Sano T, Endo K, Fujii Y, Ikeda T, Kawaguchi S, Hirose T, Hasegawa T. Acral myxoinflammatory fibroblastic sarcoma: a report of five cases and review of the literature. Virchows Arch, 442:25-30, 2003

22. Kawaguchi S, Wada T, Nagoya S, Ikeda T, Isu K, Yamashiro K, Kawai A, Ishii T, Araki N, Myoui A, Matsumoto S, Umeda T, Yoshikawa H, Hasegawa T. Extraskeletal myxoid chondrosarcoma. Cancer, 97:1285-1292, 2003

23. Fujimoto Y, Nakanishi Y, Yoshimura K, Shimoda T. Clinicopathologic study of primary malignant gastrointestinal stromal tumor of the stomach, with special reference to prognostic factors: analysis of results in 140 surgically resected patients. Gastric Cancer, 6:39-48, 2003

24. Soetikno RM, Gotoda T, Nakanishi Y, Soehendra N. Endoscopic mucosal resection. Gastrointest Endosc, 57:567-579, 2003

25. Tateishi U, Hasegawa T, Kusumoto M, Yamazaki N, Iinuma G, Muramatsu Y, Moriyama N. Metastatic angiosarcoma of the lung: spectrum of CT findings. AJR, 180:1671-1674, 2003

26. Nunobe S, Fukushima N, Yachida S, Shimada K, Kosuge T, Sakamoto M. Clear cell endocrine tumor of the pancreas which is not associated with von Hippel-Lindau Disease: report of a case. Surg Today, 33:470-474, 2003

27. Tateishi U, Hasegawa T, Makimoto A, Moriyama N. Adult neuroblastoma: radiologic and clinicopathologic features. J Comput Assist Tomogr, 27:321-326, 2003

28. Terasaki H, Niki T, Matsuno Y, Yamada T, Maeshima A, Asamura H, Hayabuchi N, Hirohashi S. Lung adenocarcinoma with mixed bronchioloalveolar and invasive components: clinicopathological features, subclassification by extent of invasive foci, and immunohistochemical characterization. Am J Surg Pathol, 27:937-951, 2003

29. Tsuda H, Mikami Y, Kaku T, Akiyama F, Hasegawa T, Okada S, Hayashi I, Kasamatsu T. Interobserver variation in the diagnosis of adenoma malignum (minimal deviation adenocarcinoma) of the uterine cervix. Pathol Int, 53:440-449, 2003

30. Yachida S, Fukushima N, Nakanishi Y, Akasu T, Kitamura H, Sakamoto M, Shimoda T. Alpha-fetoprotein-producing carcinoma of the colon: report of a case and review of the literature. Dis Colon Rectum, 46:826-831, 2003

31. Yamaguchi U, Hasegawa T, Hirose T, Fugo K, Mitsuhashi T, Shimizu M, Kawai A, Ito Y, Chuman H, Beppu Y. Sclerosing perineurioma: a clinicopathological study of five cases and diagnostic utility of immunohistochemical staining for GLUT1. Virchows Arch, 443:159-163, 2003

32. Hasegawa T, Hasegawa F, Hirose T, Sano T, Matsuno Y. Expression of smooth muscle markers in so called malignant fibrous histiocytomas. J Clin Pathol, 56:666-671, 2003

33. Igaki H, Kato H, Tachimori Y, Nakanishi Y. Prognostic evaluation of patients with clinical T1 and T2 squamous cell carcinomas of the thoracic esophagus after 3-field lymph node dissection. Surgery, 133:368-374, 2003

34. Tateishi U, Hasegawa T, Beppu Y, Kawai A, Moriyama N. Prognostic significance of grading (MIB-1 system) in patients with myxoid liposarcoma. J Clin Pathol, 56:579-582, 2003

35. Tateishi U, Hasegawa T, Miyakawa K, Sumi M, Moriyama N. CT and MRI features of recurrent tumors and second primary neoplasms in pediatric patients with retinoblastoma. Am J Roentgenol, 181:879-884, 2003

36. Yano Y, Yamamoto J, Kosuge T, Sakamoto Y, Yamasaki S, Shimada K, Ojima H, Sakamoto M, Takayama T, Makuuchi M. Combined hepatocellular and cholangiocarcinoma: a clinicopathologic study of 26 resected cases. Jpn J Clin Oncol, 33:283-287, 2003

37. Hishida T, Hasegawa T, Asamura H, Kusumoto M, Maeshima A, Matsuno Y, Suzuki K, Kondo H, Tsuchiya R. Malignant glomus tumor of the lung. Pathol Int, 53:632-636, 2003

38. Tateishi U, Hasegawa T, Beppu Y, Satake M, Moriyama N. Primary dedifferentiated liposarcoma of the retroperitoneum: prognostic significance of computed tomography and magnetic resonance imaging features. J Comput Assist Tomogr, 27:799-804, 2003

39. Tateishi U, Hasegawa T, Satake M, Moriyama N. Gastrointestinal stromal tumor: correlation of computed tomography findings with tumor grade and mortality. J Comput Assist Tomogr, 27:792-798, 2003

40. Nakagawa K, Asamura H, Matsuno Y, Suzuki K, Kondo H, Maeshima A, Miyaoka E, Tsuchiya R. Thymoma: a clinicopathologic study based on the new World Health Organization classification. J Thorac Cardiovasc Surg, 126:1134-1140, 2003

41. Tateishi U, Gladish GW, Kusumoto M, Hasegawa T, Yokoyama R, Tsuchiya R, Moriyama N. Chest wall tumors: radiologic findings and pathologic correlation: part 1. Benign tumors. Radiographics, 23:1477-1490, 2003

42. Tateishi U, Gladish GW, Kusumoto M, Hasegawa T, Yokoyama R, Tsuchiya R, Moriyama N. Chest wall tumors: radiologic findings and pathologic correlation: part 2. malignant tumors. Radiographics, 23:1491-1508, 2003

43. Yamaguchi U, Hasegawa T, Hirose T, Chuman H, Kawai A, Ito Y, Beppu Y. Low grade malignant peripheral nerve sheath tumour: varied cytological and histological patterns. J Clin Pathol, 56:826-830, 2003

44. Okada K, Hasegawa T, Yokoyama R, Beppu Y, Itoi E. Osteosarcoma with cytokeratin expression: a clinicopathologic study of six cases with an emphasis on differential diagnosis from metastatic cancer. J Clin Pathol, 56:742-746, 2003

45. Okada K, Hasegawa T, Yokoyama R, Beppu Y, Itoi E. Prognostic relevance of rosette-like features in osteosarcoma. J Clin Pathol, 56: 831-834, 2003

46. Gotoh M, Nakatani T, Masuda T, Mizuguchi Y, Sakamoto M, Tsuhchiya R, Kato H, Furuta K. Prediction of invasive activities in hepatocellular carcinomas with special reference to a-fetoprotein and des-g-carboxyprothrombin. Jpn J Clin Oncol, 33:522-526, 2003

47. Hayashi I, Tsuda H, Shimoda T, Maeshima A, Kasamatsu T, Yamada T, Tsunematsu R. Difference in cytoplasmic localization pattern of neutral mucin among lobular endocervical glandular hyperplasia, adenoma malignum, and common adenocarcinoma of the uterine cervix. Virchows Arch, 443:752-760, 2003

2. Biochemistry Division

48. Fujiwara K, Ochiai M, Ubagai T, Ohki M, Ohta T, Nagao M, Sugimura T, Nakagama H. Differential gene expression profiles in colon epithelium of two rat strains with distinct susceptibility to colon carcinogenesis after exposure to PhIP in combination with dietary high fat. Cancer Sci, 94:672-678, 2003

49. Ochiai M, Ushigome M, Fujiwara K, Ubagai T, Kawamori T, Sugimura T, Nagao M, Nakagama H. Characterization of dysplastic aberrant crypt foci in the rat colon induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Am J Pathol, 163:1607-1614, 2003

50. Osawa E, Nakajima A, Wada K, Ishimine S, Fujisawa N, Kawamori T, Matsuhashi N, Kadowaki T, Ochiai M, Sekihara H, Nakagama H. Peroxisome proliferator- activated receptor g ligands suppress colon carcinogenesis induced by azoxymethane in mice. Gastroenterology, 124:361-367, 2003

51. Yonezawa K, Nakagama H, Tajima R, Ushigome M, Ogura Y, Suuzuki KT, Yoshikawa K, Nagao M. Effects of soy protein isolate on LEC rats, a model of Wilson disease: mechanisms underlying enhancement of liver cell damage. Biochem Biophys Res Commun, 302:271-274, 2003

52. Yonezawa K, Nunomiya S, Daigo M, Ogura Y, Suuzuki KT, Enomoto K, Nakagama H, Yoshikawa K, Nagao M. Soy protein isolate enhances hepatic copper accumulation and cell damage in LEC rats. J Nutr, 133:1250-1254, 2003

53. Fukuda H, Tsuchiya N, Sato M, Yamaguchi A, Tanaka N, Nagao M, Nakagama H. DNA-binding activity of p100, a transcriptional coactivator, to single-stranded C-rich sequences. Proc Jpn Acad Ser B, 79:120-123, 2003

54. Enokizono Y, Matsugami A, Uesugi S, Fukuda H, Tsuchiya N, Sugimura T, Nagao M, Nakagama H, Katahira, M. Destruction of quadruplex by proteins, and its biological implications in replication and telomere maintenance. Nucleic Acids Res Suppl, 3:231-232, 2003

55. Minemoto Y, Uchida S, Ohtsubo M, Shimura M, Sasagawa T, Hirata M, Nakagama H, Ishizaka Y, Yamashita K. Loss of p53 induces M-phase retardation following G2 DNA damage checkpoint abrogation. Arch Biochem Biophys, 412:13-19, 2003

56. Torii N, Nozaki T, Masutani M., Nakagama H, Sugiyama T, Saito D, Asaka M, Sugimura T, Miki K. Spontaneous mutations in the Helicobacter pylori rpsL gene. Mutat Res, 535:141-145, 2003

57. El-Khamisy SF, Masutani M, Suzuki H, Caldecott KW. A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage. Nucleic Acids Res, 31:5526-5533, 2003

58. Nozaki T, Fujihara H, Watanabe M, Tsutsumi M, Nakamoto K, KusuokaO, Kamada N, Suzuki H, Nakagama H, Sugimura T, Masutani M. Parp-1 deficiency implicated in colon and liver tumorigenesis induced by azoxymethane. Cancer Sci, 94:497-500, 2003

59. Shibata A, Masutani M, Nozaki T, Kamada N, Fujihara H, Masumura K, Nakagama H, Sugimura T, Kobayashi S, Suzuki H, Nohmi T. Improvement of the Spi- assay for mutations in gpt delta mice by including magnesium ions during plaque formation. Environ Mol Mutagen, 41:370-372, 2003

60. Masutani M, Nakagama H, Sugimura T. Poly(ADP-ribose) and Carcinogenesis. Genes Chromosomes Cancer, 38:339-348, 2003

61. Watanabe F, Masutani M, Kamada N, Suzuki H, Nakagama H, Sugimura T, Teraoka H. Impairment in S-phase entry of splenocytes of Parp-1 knockout mice. Proc Jpn Acad Ser B, 79:248-251, 2003

62. Hemberger M, Nozaki T, Masutani M, Cross J C. Differential expression of angiogenic and vasodilatory factors by invasive trophoblast giant cells depending on depth of invasion. Dev Dyn, 227:185-191, 2003

63. Hemberger M, Nozaki T, Winterhager E, Yamamoto H, Nakagama H, Kamada N, Suzuki H, Masutani M, Cross J C. Parp1-deficiency induces differentiation of ES cells into trophoblast derivatives. Dev Biol, 257:371-381, 2003

64. Gunji A, Fujihara H, Kamada N, Omura K, Jishage K, Nakagama H, Sugimura T, Masutani M. Lack of altered frequency of sister-chromatid exchanges in poly(ADP-ribose)glycohydrolase-deficient mouse ES cells treated with methylmethanesulfonate. Proc Jpn Acad Ser B, 79:305-307, 2003

3. Experimental Pathology and Chemotherapy Division

65. Tanaka T, Kohno H, Nomura E, Taniguchi H, Tsuno T, Tsuda H. A novel geranylated derivative, ethyl3-(4'-geranyloxy-3'-methoxyphenyl)-2-propenoate, synthesized from ferulic acid suppresses carcinogenesis and inducible nitric oxide synthase in rat tongue. Oncology, 64:166-175, 2003

66. Matsuoka Y, Fukamachi K, Hamaguchi T, Toriyama-Baba H, Kawaguchi H, Kusunoki M, Yoshida H, Tsuda H. Rapid emergence of mammary preneoplastic and malignant lesions in human c-Ha-ras proto-oncogene transgenic rats: possible application for screening of chemopreventive agents. Toxicol Pathol, 31: 632-637, 2003

67. Tsuda H, Fukushima S, Wanibuchi H, Morimura K, Nakae D, Imaida K, Tatematsu M, Hirose M, Wakabayashi K, Moore MA. Value of GST-P positive preneoplastic Hepatic foci in dose-response studies of hepatocarcinogenesis: evidence for practical thresholds with both genotoxic and nongenotoxic carcinogens. Toxicol Pathol, 31:80-86, 2003

68. Fukushima S, Moore MA, Tsuda H. Appropriate models and an understanding of carcinogenic mechanisms-requirements for hazard risk assessment. Asian Pacific J Cancer Prev, 4:75-78, 2003

69. Fukushima S, Wanibuchi H, Morimura K, Wei M, Nakae D, Konishi Y, Tsuda H, Takasuka N, Imaida K, Shirai T, Tatematsu M, Tsukamoto T, Hirose M, Furukawa F. Lack of initiation activity in rat liver of low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline. Cancer Lett, 191:35-40, 2003

70. Moore MA, Kunimoto T, Tsuda H. Cancer screening literature in the period 2000-2002: pointers to future research avenues. Asian Pacific J Cancer Prev, 4:57-60, 2003

71. Moore MA, Tajima K, Tsuda H. Epidemiology of the major cancers in the Asian Pacific. Proc Jpn Acad Ser B, 79:27-33, 2003

72. Moore MA, Tsuda H. Targeting the workplace for cervical and mammary cancer screening? Asian Pacific J Cancer Prev, 4:1-2, 2003

73. Barkalow KL, Italiano JE, Chou DE, Matsuoka Y, Bennett V, Hartwig JH. a-Adducin dissociates from F-actin and spectrin during platelet activation. J Cell Biol, 161:557-570, 2003

74. Chaimuangraj S, Thamavit W, Tsuda H, Moore MA. Experimental investigation of opisthorchiasis-associated cholangiocarcinoma induction in the syrian hamster-pointers for control of the human disease. Asian Pacific J Cancer Prev, 4:87-93, 2003

75. Moore MA, Qiao Y-L, Threlfall TJ, Tokudome S, Tsuda H, Tajima K. The APOCP/APJCP-taking stock and planning for the future. Asian Pacific J Cancer Prev, 4:79-80, 2003

76. Moore MA, Tajima K, Anh PH, Aydemir G, Basu PS, Bhurgri Y, Chen K, Gajalakshmi V, Hirose K, Mosavi-Jarrahi A, Ngoan LT, Qiao Y-L, Shin HR, Sriamporn S, Srivatanakul P, Tokudome S, Yoo K-Y, Tsuda H. Grand challenges in global health and the practical prevention program? Asian focus on cancer prevention in females of the developing world. Asian Pacific J Cancer Prev, 4:153-165, 2003

77. Moore MA, Tsuda H. Can risk assessment and chemoprevention research rely on surrogates for tumour yield? Asian Pacific J Cancer Prev, 4:167-168, 2003

78. Tsuda H, Naito A, Kim CK, Fukamachi K, Nomoto H, Moore MA. Carcinogenesis and its modification by environmental endocrine disruptors: in vivo experimental and epidemiological findings. Jpn J Clin Oncol, 33:259-270, 2003

79. Goldberg GS, Alexander DB, Pellicena P, Zhang Z-Y, Tsuda H, Miller WT. Src phosphorylates cas on tyrosine 253 to promoto migration of transformed cells. J Biol Chem, 278:46533-46540, 2003

4. Biology Division

80. Ohgaki H, Yasui W, Yokota J. Genetic pathways to human cancer. In: Vainio HU, Hietanen EK (eds), Mechanisms in Carcinogenesis and Cancer Prevention. Germany, Springer-Verlag, pp 25-39, 2003

81. Yokota J, Nishioka M, Tani M, Kohno T. Genetic alterations responsible for metastatic phenotypes of lung cancer cells. Clin Exp Metastasis, 20:189-193, 2003

82. Park M-J, Shimizu K, Nakano T, Park YB, Kohno T, Tani M, Yokota J. Pathogenetic and biologic significance of TP14ARF alterations in nonsmall cell lung carcinoma. Cancer Genet Cytogenet, 141:5-13, 2003

83. Sasaki S, Kitagawa Y, Sekido Y, Minna JD, Kuwano H, Yokota J, Kohno T. Molecular processes of chromosome 9p21 deletions in human cancers. Oncogene, 22:3792-3798, 2003

84. Yanagitani N, Kohno T, Kim J-G, Kunitoh H, Tamura T, Takei Y, Tsuchiya S, Saito R, Yokota J. Identification of D19S246 as a novel lung adenocarcinoma susceptibility locus by genome survey with 10-cM resolution microsatellite markers. Cancer Epidemiol Biomarkers Prev, 12:366-371, 2003

85. Wang Y, Song J-P, Ikeda M, Shinmura K, Yokota J, Sugimura H. Ile-Leu substitution (I415L) in germline E-cadherin gene (CDH1) in Japanese familial gastric cancer. Jpn J Clin Oncol, 33:17-20, 2003

86. Suriano G, Mulholland D, Wever O, Ferreira P, Mateus AR, Bruyneel E, Nelson CC, Mareel MM, Yokota J, Huntsman D, Seruca R. The intracellular E-cadherin germline mutation V832 M lacks the ability to mediate cell-cell adhesion and to suppress invasion. Oncogene, 22:5716-5719, 2003

87. Yamane A, Shinmura K, Sunaga N, Saitoh T, Yamaguchi S, Shinmura Y, Yoshimura K, Murakami H, Nojima Y, Kohno T, Yokota J. Suppressive activities of OGG1 and MYH proteins against G:C to T:A mutations caused by 8-hydroxyguanine but not by benzo[a]pyrene diol epoxide in human cells in vivo. Carcinogenesis, 24:1031-1037, 2003

88. Nagashima M, Shiseki M, Pedeux RM, Okamura S, Kitahama-Shiseki M, Miura K, Yokota J, Harris CC. A novel PHD-finger motif protein, p47ING3, modulates p53-mediated transcription, cell cycle control, and apoptosis. Oncogene, 22:343-350, 2003

89. Shiseki M, Nagashima M, Pedeux RM, Kitahama-Shiseki M, Miura K, Okamura S, Onogi H, Higashimoto Y, Appella E, Yokota J, Harris CC. p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity. Cancer Res, 63:2373-2378, 2003

90. Nakano T, Tani M, Ishibashi Y, Kimura K, Park Y-B, Imaizumi N, Tsuda H, Aoyagi K, Sasaki H, Ohwada S, Yokota J. Biological properties and gene expression associated with metastatic potential of human osteosarcoma. Clin Exp Metastasis, 20:665-674, 2003

91. Shindo-Okada N, Iigo M. Expression of the Arp11 gene suppresses the tumorigenicity of PC-14 human lung adenocarcinoma cells. Biochem Biophy Res Commun, 312:889-896, 2003

92. Onishi Y, Tsukada K, Yokota J, Raz A. Overexpression of autocrine motility factor receptor (AMFR) in NIH3T3 fibroblasts induces cell transformation. Clin Exp Metastasis, 20:51-58, 2003

5. Pharmacology Division

93. Asada-Mikami R, Heike Y, Harada Y, Kanai S, Ikarashi Y, Kato K, Shirakawa K, Takaue Y, Abe T, Wakasugi H. Increased expansion of Va24+ T cells derived from G-CSF-mobilized peripheral blood stem cells as compared to peripheral blood mononuclear cells following a-galactosylceramide stimulation. Cancer Sci, 94:383-388, 2003

94. Kato K, Ikarashi Y, Sugahara T, Yasumoto A, Sancho D, Yoshida M, Takaue Y, Kobayashi Y, Sanchez-Madrid F, Wakasugi H. U5A2-13, an antigen originally found on mouse NK-like T cells, is an early inducible cell surface antigen during lymphoid activation. Cell Immunol, 221:27-36, 2003

95. Ishida H, Murata N, Tada M, Okada N, Hashimoto D, Kubota S, Shirakawa K, Wakasugi H. Determining the levels of matrix metalloproteinase-9 in portal and peripheral blood is useful for predicting liver metastasis of colorectal cancer. Jpn J Clin Oncol, 33:186-191, 2003

96. Yoshida M, Heike Y, Ohno S, Ikekawa T, Wakasugi H. Involvement of PKC bII in anti-proliferating action of a new antitumor compound gnidimacrin. Int J Cancer, 105:601-606, 2003

97. Araya H, Sahai M, Singh S, Singh AK, Yoshida M, Hara N, Fujimoto Y. Squamocin-O1 and squamocin-O2, new adjacent bis-tetrahydrofuran acetogenins from the seeds of annona squamosa. Phytochemistry, 61:999-1004, 2002

98. Nakai K, Mineishi S, Kami M, Saito T, Hori A, Kojima R, Imataki O, Hamaki T, Yoshihara S, Ohnishi M, Kim S-W, Ando T, Fumitoh A, Kanda Y, Makimoto A, Tanosaki R, Kanai S, Heike Y, Ohnishi T, Kawano Y, Wakasugi H, Takaue Y. Antithymocyte globulin affects the occurrence of acute and chronic graft-versus-host disease after a reduced-intensity conditioning regimen by modulating mixed chimerism induction and immune reconstitution. Transplantation, 75:2135-2143, 2003

99. Saito T, Kanda Y, Nakai K, Kim S-W, Arima F, Kami M, Tanosaki R, Tobinai K, Wakasugi H, Heike Y, Mineishi S, Takaue Y. Immune reconstitution following reduced-intensity transplantation with cladribine, busulfan, and antithymocyte globulin: serial comparison with conventional myeloablative transplantation. Bone Marrow Transplantation, 32:601-608, 2003

100. Nishikawa H, Kato T, Tanida K, Hiasa A, Tawara I, Ikeda H, Ikarashi Y, Wakasugi H, Kronenberg M, Nakayama T, Taniguchi M, Kuribayashi K, Old LJ, Shiku H. CD4+CD25+T cells responding to serologically defined autoantigens suppress antitumor immune responses. PNAS, 100:10902-10906, 2003

101. Matsuda S, Matsuda K, Ito Y. Separation of phospholipids and glycolipids using analytical toroidal-coil counter-current chromatographyII. Comparison of the hydrophobicity between Mycoplasma fermentans and human-brain lipids. J Liq Chrom Rel Technol, 26:1135-1147, 2003

102. Kanzawa F, Akiyama Y, Saijo N, Nishio K. In vitro effects of combinations of cis-amminedichloro (2-methylpyridine) platinum (II) (ZD0473) with other movel anticancer drugs on the growth of SBC-3, a human small cell lung cancer cell line. Lung Cancer, 40:325-332, 2003

103. Nishiyama N, Okazaki S, Cabral H, Miyamoto M, Kato Y, Sugiyama Y, Nishio K, Matsumura Y, Kataoka K. Novel cisplatin-incorporated polymeric micelles can eradicate solid tumors in mice. Cancer Res, 63:8977-8983, 2003

104. Usuda J, Inomata M, Fukumoto H, Iwamoto Y, Suzuki T, Kuh HJ, Fukuoka K, Kato H, Saijo N, Nishio K. Restoration of p53 gene function in 12-O-tetradecanoylphorbor 13-acetate-resistant human leukemia K562/TPA cells. Int J Oncol, 22:81-86, 2003

105. Suzuki T, Agui M, Togawa T, Naganuma A, Nishio K, Tanabe S. MRP5b/SMRP mRNA is highly expressed in metallothionein-deficient mouse liver. J Health Sci, 49:524-526, 2003

106. Saijo N, Nishio K, Tamura T. Translational and clinical studies of target-based cancer therapy. Int J Clin Oncol, 8:187-192, 2003

107. Natsume T, Watanabe J, Koh Y, Fujio N, Ohe Y, Horiuchi T, Saijo N, Nishio K, Kobayashi M. Antitumor activity of TZT-1027 (Soblidotin) against VEGF-secreting human lung cancer in vivo. Cancer Sci, 94:826-833, 2003

108. Saijo N, Tamura T, Nishio K. Strategy for the development of novel anticancer drugs. Cancer Chemother Pharmacol, 52:s97-s101, 2003

109. Tsunoda T, Koh Y, Koizumi F, Tsukiyama S, Ueda H, Taguchi F, Saijo N, Nishio K. Differential gene expression profiles and identification of the genes relevant to clinicopathologic factors in colorectal cancer selected by cDNA array method in combination with principal component analysis. Int J Oncol, 23:49-59, 2003

110. Hirama M, Takahashi F, Takahashi K, Akutagawa S, Shimizu K, Soma S, Shimanuki Y, Nishio K, Fukuchi Y. Osteopontin overproduced by tumor cells acts as a potent angiogenic factor contributing to tumor growth. Cancer Lett, 198:107-117, 2003

111. Yamanaka R, Akutagawa S, Taguchi F, Yajima N, Tsuchiya N, Uzuka T, Morii K, Takahashi H, Tanaka R, Saijo N, Nishio K. Selection of surrogate marker genes in primary central nervous system lymphomas for radio-chemotherapy by DNA array analysis of gene expression profiles. Int J Oncol, 23:913-923, 2003

6. Cancer Medicine and Biophysics Division

112. Tanikawa C, Matsuda K, Fukuda S, Nakamura Y, Arakawa H. p53RDL1 regulates p53-dependent apoptosis. Nat Cell Biol, 5:216-223, 2003

113. Kimura T, Gotoh M, Nakamura Y, Arakawa H. hCDC4b, a regulator of cyclin E, as a direcr transcriptional target of p53. Cancer Sci, 94:431-436, 2003

114. Ng C-C, Arakawa H, Fukuda S, Kondoh H, Nakamura Y. p53RFP, a p53-inducible RING-finger protein, regulates the stability of p21WAF1. Oncogene, 22:4449-4458, 2003

115. Ueda K, Arakawa H, Nakamura Y. Dual-specificity phosphatase 5 (DUSP5) as a direct transcriptional target of tumor suppressor p53. Oncogene, 22:5586-5591, 2003

116. Kimura T, Takeda S, Sagiya Y, Gotoh M, Nakamura Y, Arakawa H. Impaired function of p53R2 in Rrm2b-null mice causes severe renal failure through attenuation of dNTP pools. Nat Genet, 34:440-445, 2003

117. Otsuki Y, Tanaka M, Kamo T, Kitanaka C, Kuchino Y, Sugimura H. Guanine nucleotide exchange factor, Tiam1, directly binds to c-Myc and interferes with c-Myc-mediated apoptosis in Rat-1 fibroblasts. J Biol Chem, 278:5132-5140, 2003

118. Sugiyama A, Miyagi Y, Komiya Y, Kurabe N, Kitanaka C, Kato N, Nagashima Y, Kuchino Y, Tashiro F. Forced expression of antisense 14-3-3beta RNA suppresses tumor cell growth in vitro and in vivo. Carcinogenesis, 24:1549-1559, 2003

7. Growth Factor Division

119. Huang J, Asawa T, Takato T, Sakai R. Cooperative roles of Fyn and cortactin in cell migration of metastatic murine melanoma. J. Biol. Chem. 278, 48367-48376, 2003

120. Li Z, Tanaka M, Kataoka H, Nakamura R, Sanjar R, Shinmura K, Sugimura H, EphA2 Up-regulation induced by deoxycholic acid in human colon carcinoma cells, an involvement of extracellular signal regulated kinase and p53- independence. J Cancer Res Clin Oncol, 129:703-708, 2003

121. Kameya T, Tsukada T, Futami H, Yamaguchi K. Multiple endocrine neoplasia. In:Lloyd RL (ed), Endocrine Pathology: Differential Diagnosis and Molecular Advances. USA, Humana Press Inc., pp 359-375, 2003

122. Futami H, Egawa S, Takasaki K, Tsukada T, Shiraishi M, Yamaguchi K. Allelic loss of DNA locus of the RET proto-oncogene in small cell lung cancer. Cancer Lett, 195:59-65, 2003

8. Molecular Oncology Division

123. Imamura T, Kakazu N, Hibi S, Morimoto A, Fukushima Y, Ijuin I, Hada S, Kitabayashi I, Abe T, Imashuku S. Rearrangement of the MOZ gene in pediatric therapy-related myelodysplastic syndrome with a novel chromosomal translocation t(2;8)(p23;p11). Genes Chromosomes Cancer 36:413-419, 2003

9. Cancer Information and Epidemiology Division

124. Kaneko S, Ishikawa KB, Yoshimi I, Marugame T, Hamashima C, Kamo K, Mizuno S, Sobue T. Projection of lung cancer mortality in Japan. Cancer Sci, 94:919-923, 2003

125. Yoshimi I, Ohshima A, Ajiki W, Tsukuma H, Sobue T. A comparison of trends in the incidence rate of lung cancer by histological type in the Osaka Cancer Registry, Japan and in the Surveillance, Epidemiology and End results Program, USA. Jpn J Clin Oncol, 33:98-104, 2003

126. Yamamoto S, Sobue T, Kobayashi M, Sasaki S, Tsugane S. Soy, isoflavone, and breast cancer risk in Japan. J Natl Cancer Inst, 95:906-913, 2003

127. Ishihara J, Sobue T, Yamamoto S, Yoshimi I, Sasaki S, Kobayashi M, Takahashi T, Iitoi Y, Akabane M, Tsugane S. Validity and reproducibility of a self-administered food frequency questionnaire in the JPHC Study Cohort II: study design, participant profile and results in comparison with Cohort I. J Epidemiol, 13:s134-s147, 2003

128. Ishihara J, Sobue T, Yamamoto S, Sasaki S, Tsugane S, the JPHC Study Group. Demographics, lifestyles, health characteristics, and dietary intake among dietary supplement users in Japan. Int J Epidemiol, 32:546-553, 2003

129. Liu Y, Yoshimura K, Yamaguchi N, Shinmura K, Yokota J, Katai H. Causation of Borrmann type 4 gastric cancer: Heritable factors or environmental factors? Gastric Cancer, 6:17-23, 2003

130. Kaneko S, Tamakoshi A, Ohno Y, Mizoue T, Yoshimura T, the JACC Study Group. Menstrual and reproductive factors and the mortality risk of gastric cancer in Japanese menopausal females. Cancer Causes Control, 14:53-59, 2003

131. Iwasaki T, Murata M, Ohshima S, Miyake T, Kudo S, Inoue Y, Narita M, Yoshimura T, Akiba S, Tango T, Yoshimoto Y, Shimizu Y, Sobue T, Kusumi S, Yamagishi C, Matsudaira H. Second analysis of mortality of nuclear industry workers in Japan, 1986-1997. Radiat Res, 159:228-238, 2003

132. Hamashima C, Yoshida K. What is important for the introduction of cancer screening in the workplace? Asia Pacific J Cancer Prev, 4:39-43, 2003

133. Nakajima M, Saito H, Soma Y, Sobue T, Tanaka M, Munakata A. Prevention of advanced colorectal cancer by screening using the immunochemical faecal occult blood test: a case-control study. Br J Cancer, 89:23-28, 2003

134. Mizoue T, Yoshimura T, Tokui N, Hoshiyama Y, Yatsuya H, Sakata K, Kondo T, Kikuchi S, Toyoshima H, Hayakawa N, Tamakoshi A, Ohno Y, Fujino Y, Kaneko S, the Japan Collaborative Cohort Study Group. Prospective study of screening for stomach cancer in Japan. Int J Cancer, 106:103-107, 2003

135. Ohtsu A, Shimada Y, Shirao K, Boku N, Hyodo I, Saitoh H, Yamamichi N, Miyata Y, Ikeda N, Yamamoto S, Fukuda H, Yashida S. Randomized phase III trial of fluorouracil alone versus fluorouracil plus cisplatin versus uracil and tegafur plus mitomycin in patients with unresectable, advanced gastric cancer: The Japan Clinical Oncology Group Study (JCOG9205). J Clin Oncol, 21:54-59, 2003

136. Nashimoto A, Nakajima T, Furukawa H, Kitamura M, Kinoshita T, Yamamura Y, Sasako M, Kunii Y, Motohashi H, Yamamoto S; Gastric Cancer Surgical Study Group, Japan Clinical Oncology Group. Randomized trial of adjuvant chemotherapy with mitomycin, Fluorouracil, and Cytosine arabinoside followed by oral Fluorouracil in serosa-negative gastric cancer: Japan Clinical Oncology Group 9206-1. J Clin Oncol, 21:2282-2287, 2003

137. Ando N, Iizuka T, Ide H, Ishida K, Shinoda M, Nishimaki T, Takiyama W, Watanabe H, Isono K, Aoyama N, Makuuchi H, Tanaka O, Yamana H, Ikeuchi S, Kabuto T, Nagai K, Shimada Y, Kinjo Y, Fukuda H. Surgery plus chemotherapy compared with surgery alone for localized squamous cell carcinoma of the thoracic esophagus: A Japan Clinical Oncology Group Study-JCOG9204. J Clin Oncol, 21:4592-4596, 2003

138. Ohtsu A, Boku N, Yoshioka T, Hyodo I, Shirao K, Shimada Y, Saitoh S, Nakamura A, Yamamichi N, Yamamoto S, Yoshida S. A phase II study of irinotecan in combination with 120-h infusion of 5-fluorouracil in patients with metastatic colorectal carcinoma: Japan Clinical Oncology Group Study (JCOG9703). Jpn J Clin Oncol, 33:28-32, 2003

139. Sekine I, Nishiwaki Y, Kakinuma R, Kubota K, Hojo F, Matsumoto T, Ohmatsu H, Goto K, Kodama T, Eguchi K, Shinkai T, Tamura T, Ohe Y, Kunitoh H, Yoshimura K, Saijyo N. Phase I/II trial of weekly cisplatin, etoposide, and irinotecan chemotherapy for metastatic lung cancer: JCOG9507. Br J Cancer, 88:808-813, 2003

140. Ohe Y, Ishizuka N, Tamura T, Sekine I, Nishiwaki Y, Saijo N, the Japan Clinical Oncology Group. Long-term follow-up of patients with unresectable locally advanced non-small cell lung cancer treated with chemoradiotherapy: a retrospective analysis of the data from the Japan Clinical Oncology Group trials (JCOG0003A). Cancer Sci, 94:729-734, 2003

10. Virology Division

141. Imabayashi H, Mori T, Gojo S, Kiyono T, Sugiyama T, Irie R, Isogai T, Hata J, Toyama Y, Umezawa A. Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis. Exp Cell Res, 288:35-50, 2003

142. Kyo S, Nakamura M, Kiyono T, Maida Y, Kanaya T, Tanaka M, Yatabe N, Inoue M. Successful immortalization of endometrial glandular cells with normal structural and functional characteristics. Am J Pathol, 163:2259-2269, 2003

143. Kato N, Sugiyama K, Namba K, Dansako H, Nakamura T, Takami M, Naka K, Nozaki A, Shimotohno K. Establishment of a hepatitis C virus subgenomic replicon derived from human hepatocytes infected in vitro. Biochem Biophys Res Commun, 306:756-766, 2003

144. Yonemura Y, Sakurai S, Yamamoto H, Endou Y, Kawamura T, Bandou E, Elnemr A, Sugiyama K, Sasaki T, Akiyama T, Takasawa S, Okamoto H. REG gene expression is associated with the infiltrating growth of gastric carcinoma. Cancer, 98:1394-1400, 2003

145. Sugiyama Y, Dan S, Yoshida Y, Akiyama F, Sugiyama K, Hirai Y, Matsuura M, Miyata S, Ushijima M, Hasumi K, Yamori T. A large-scale gene expression comparison of microdissected, small-sized endometrial cancers with or without hyperplasia matched to same-patient normal tissue. Clin Cancer Res, 9:5589-5600, 2003

146. Ohta S, Tatsumi Y, Fujita M, Tsurimoto T, Obuse C. The ORC1 cycle in human cells: II. Dynamic change of human ORC complex during the cell cycle. J Biol Chem, 278:41535-41540, 2003

147. Fujita M, Ichinose S, Kiyono T, Tsurumi T, Omori A. Establishment of latrunculin-A resistance in HeLa cells by expression of R183A D184A mutant b-actin. Oncogene, 22:627-631, 2003

148. Bruemmer D, Yin F, Liu J, Berger JP, Kiyono T, Chen J, Fleck E, Van Herle AJ, Forman BM, Law RE. Peroxisome proliferator-activated receptor g inhibits expression of minichromosome maintenance proteins in vascular smooth muscle cells. Mol Endocrinol, 17:1005-1018, 2003

149. Bruemmer D, Yin F, Liu J, Kiyono T, Fleck E, Van Herle AJ, Graf K, Law RE. Atorvastatin inhibits expression of minichromosome maintenance proteins in vascular smooth muscle cells. Eur J Pharmacol, 462:15-23, 2003

150. Bruemmer D, Yin F, Liu J, Kiyono T, Fleck E, Van Herle AJ, Law RE. Rapamycin inhibits E2F-dependent expression of minichromosome maintenance proteins in vascular smooth muscle cells. Biochem Biophys Res Commun, 303:251-258, 2003

151. Bruemmer D, Yin F, Liu J, Kiyono T, Fleck E, Van Herle AJ, Law RE. Expression of minichromosome maintenance proteins in vascular smooth muscle cells is ERK/MAPK dependent. Exp Cell Res, 290:28-37, 2003

152. Ueno H, Sakita-Ishikawa M, Morikawa Y, Nakano T, Kitamura T, Saito M. A stromal cell-derived membrane protein that supports hematopoietic stem cells. Nat Immunol, 4:457-463, 2003

11. Genetics Division

153. Aoyagi K, Tatsuta T, Nishigaki M, Akimoto S, Tanabe C, Omoto Y, Hayashi S, Sakamoto H, Sakamoto M, Yoshida T, Terada M, Sasaki H. A faithful method for PCR-mediated global mRNA amplification and its integration into microarray analysis on laser-captured cells. Biochem Biophys Res Commun, 300:915-920, 2003

154. Tanabe C, Aoyagi K, Sakiyama T, Kohno T, Yanagitani N, Akimoto S, Sakamoto M, Sakamoto H, Yokota J, Ohki M, Terada M, Yoshida T, Sasaki H. Evaluation of a whole-genome amplification method based on adaptor-ligation PCR of randomly sheared genomic DNA. Genes Chromosoms Cancer, 38:168-176, 2003

155. Ohnishi S, Ohnami S, Laub F, Aoki K, Suzuki K, Kanai Y, Haga K, Asaka M, Ramirez F, Yoshida T. Downregulation and growth inhibitory effect of epithelial-type Kruppel-like transcription factor KLF4, but not KLF5, in bladder cancer. Biochem Biophys Res Commun, 308:251-256, 2003

156. Sumitsuji I, Sugano K, Matsui T, Fukayama N, Yamaguchi K, Akasu T, Fujita S, Moriya Y, Yokoyama R, Nomura S, Yoshida T, Kodama T, Ogawa M. Frequent genomic disorganisation of MLH1 in hereditary non-polyposis colorectal cancer (HNPCC) screened by RT-PCR on puromycin treated samples. J Med Genet, 40:e30, 2003

157. Morita E, Narikiyo M, Yano A, Nishimura E, Igaki H, Sasaki H, Terada M, Hanada N, Kawabe R. Different frequencies of Streptococcus anginosus infection in oral cancer and esophageal cancer. Cancer Sci, 94:492-496, 2003

158. Suzuki K, Ohnami S, Tanabe C, Sasaki H, Yasuda J, Katai H, Yoshimura K, Terada M, Perucho M, Yoshida T. The genomic damage estimated by arbitrarily primed PCR DNA fingerprinting is useful for the prognosis of gastric cancer. Gastroenterology, 125:1330-1340, 2003

159. Kasahara H, Tanaka E, Fukuyama N, Sato E, Sakamoto H, Tabata Y, Ando K, Iseki H, Shinozaki Y, Kimura K, Kuwabara E, Koide S, Nakazawa H, Mori H. Biodegradable gelatin hydrogel potentiates the angiogenic effect of fibroblast growth factor 4 plasmid in rabbit hindlimb ischemia. J Am Coll Cardiol, 41:1056-1062, 2003

160. Suzuki K, Aoki K, Ohnami S, Yoshida K, Kazui T, Kato N, Inoue K, Kohara M, Yoshida T. Adenovirus-mediated gene transfer of interferon a improves dimethylnitrosamine-induced liver cirrhosis in rat model. Gene Ther, 10:765-773, 2003

161. Suzuki K, Aoki K, Ohnami S, Yoshida K, Kazui T, Kato N, Inoue K, Kohara M, Yoshida T. Adenovirus-mediated gene transfer of interferon a inhibits hepatitis C virus replication in hepatocytes. Biochem Biophys Res Commun, 307:814-819, 2003

162. Ohnami S, Aoki K, Yoshida K, Ohnami S, Hatanaka K, Suzuki K, Sasaki H, Yoshida T. Expression profiles of pancreatic cancer cell lines infected with antisense K-ras-expressing adenoviral vector. Biochem Biophys Res Commun, 309:798-803, 2003

163. Yoshida T, Yoshimura K. Outline of disease gene hunting approaches in the Millennium Genome Project of Japan. Proc Jpn Acad, 79:34-50, 2003

164. Saeki M, Saito Y, Jinno H, Sai K, Komamura K, Ueno K, Kamakura S, Kitakaze M, Shirao K, Minami H, Ohtsu A, Yoshida T, Saijo N, Ozawa S, Sawada J. Three novel single nucleotide polymorphisms in UGT1A9. Drug Metab Pharmacokin, 18:146-149, 2003

165. Itoda M, Saito Y, Shirao K, Minami H, Ohtsu A, Yoshida T, Saijo N, Suzuki H, Sugiyama Y, Ozawa S, Sawada J. Eight novel single nucleotide polymorphisms in ABCG2/BCRP in Japanese cancer patients administered irinotacan. Drug Metab Pharmacokin, 18:212-217, 2003

166. Sai K, Kaniwa N, Itoda M, Saito Y, Hasegawa R, Komamura K, Ueno K, Kamakura S, Kitakaze M, Shirao K, Minami H, Ohtsu A, Yoshida T, Saijo N, Kitamura Y, Kamatani N, Ozawa S, Sawada J. Haplotype analysis of ABCB1/MDR1 blocks in a Japanese population reveals genotype-dependent renal clearance of irinotecan. Pharmacogenetics, 13:741-757, 2003

167. Kim S-R, Nakamura T, Saito Y, Sai K, Nakajima T, Saito H, Shirao K, Minami H, Ohtsu A, Yoshida T, Saijo N, Ozawa S, Sawada J. Twelve novel single nucleotide polymorphisms in the CES2 gene encoding human carboxylesterase 2 (hCE-2). Drug Metab Pharmacokin, 18:SNP29(327)-SNP34(332), 2003

168. Jinno H, Saeki M, Tanaka-Kagawa T, Hanioka N, Saito Y, Ozawa S, Ando M, Shirao K, Minami H, Ohtsu A, Yoshida T, Saijo N, Sawada J. Functional characterization of wild-type and variant (T202I and M59I) human UDP-glucuronosyltransferase 1A10. Drug Metab Dispos, 31:528-532, 2003

169. Jinno H, Saeki M, Saito Y, Tanaka-Kagawa T, Hanioka N, Sai K, Kaniwa N, Ando M, Shirao K, Minami H, Ohtsu A, Yoshida T, Saijo N, Ozawa S, Sawada J. Functional characterization of human UDP-glucuronosyltransferase 1A9 variant, D256N, found in Japanese cancer patients. J Pharmacol Exp Ther, 306:688-693, 2003

170. Katoh M, Katoh M. Recombination cluster around FGFR2-WDR79-HTPAPL locus on human chromosome 10q26. Int J Mol Med, 11:579-583, 2003

171. Katoh M, Katoh M. FGFR2 and WDR11 are neighboring oncogene and tumor suppressor gene on human chromosome 10q26. Int J Oncol, 22:1155-1159, 2003

172. Katoh M, Katoh M. Identification and characterization of human DAAM2 gene in silico. Int J Oncol, 22:915-920, 2003

173. Katoh M, Katoh M. Identification and characterization of human SNAIL3 (SNAI3) gene in silico. Int J Mol Med, 11:383-388, 2003

174. Katoh M, Katoh M. Identification and characterization of human PRICKLE1 and PRICKLE2 genes as well as mouse Prickle1 and Prickle2 genes homologous to Drosophila tissue polarity gene prickle. Int J Mol Med, 11:249-256, 2003

175. Katoh M, Katoh M. Identification and characterization of human Inscuteable gene in silico. Int J Mol Med, 11:111-116, 2003

176. Katoh M, Katoh M. Identification and characterization of human DAPPER1 and DAPPER2 gene in silico. Int J Oncol, 22:907-913, 2003

177. Katoh M, Katoh M. Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico. Int J Oncol, 22:1161-1168, 2003

178. Katoh M, Katoh M. MGC9753 gene, located within PPP1R1B-STARD3-ERBB2-GRB7 amplicon on human chromosome 17q12, encodes the seven-transmembrane receptor with extracellular six-cystein domain. Int J Oncol, 22:1369-1374, 2003

179. Katoh M, Katoh M. KIAA1735 gene on human chromosome 11q23.1 encodes a novel protein with myosine-tail homologous domain and C-terminal DIX domain. Int J Oncol, 23:145-150, 2003

180. Katoh M, Katoh M. FLJ10261 gene, located within the CCND1-EMS1 locus on human chromosome 11q13, encodes the eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products. Int J Oncol, 22:1375-1381, 2003

181. Katoh M, Katoh M. MGC29506 gene, frequently down-regulated in intestinal-type gastric cancer, encodes secreted-type protein with conserved cysteine residues. Int J Oncol, 23:235-241, 2003

182. Katoh M, Katoh M. Identification and characterization of mouse Erbb2 gene in silico. Int J Oncol, 23:831-835, 2003

183. Katoh M, Katoh M. Identification and characterization of ASXL2 gene in silico. Int J Oncol, 23:845-850, 2003

184. Katoh M, Katoh M. Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31. Int J Oncol, 23:541-547, 2003

185. Katoh M, Katoh M. IGSF11 gene, frequently up-regulated in intestinal-type gastric cancer, encodes adhesion molecule homologous to CXADR, FLJ22415 and ESAM. Int J Oncol, 23:525-531, 2003

186. Katoh M. WNT2 and human gastrointestinal cancer (Review). Int J Mol Med, 12:811-816, 2003

187. Katoh M. Trefoil factors and human gastric cancer (Review). Int J Mol Med, 12:3-9, 2003

188. Katoh M, Katoh M. Evolutionary conservation of CCND1-ORAOV1-FGF19-FGF4 locus from zebrafish to human. Int J Mol Med, 12:45-50, 2003

189. Katoh M, Katoh M. CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family. Int J Mol Med, 11:683-689, 2003

190. Katoh M, Katoh M. FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains. Int J Mol Med, 11:791-797, 2003

191. Katoh M, Katoh M. Identification and characterization of human BCL9L gene and mouse Bcl9l gene in silico. Int J Mol Med, 12:643-649, 2003

192. Katoh M, Katoh M. Identification and characterization of human FNBP3 gene in silico. Int J Mol Med, 12:651-656, 2003

193. Katoh M, Katoh M. Identification and characterization of LASP2 gene in silico. Int J Mol Med, 12:405-410, 2003

194. Katoh M, Katoh M. Identification and characterization of mouse Ppfia1 gene in silico. Int J Mol Med, 12:263-267, 2003

195. Katoh M, Katoh M. Identification and characterization of human ZPBP-like gene in silico. Int J Mol Med, 12:399-404, 2003

196. Katoh M, Katoh M. Identification and characterization of TRIP8 gene in silico. Int J Mol Med, 12:817-821, 2003

197. Katoh M, Katoh M. Identification and characterization of FLJ10737 and CAMTA1 genes on the commonly deleted region of neuroblastoma at human chromosome 1p36.31-p36.23. Int J Oncol, 23:1219-1224, 2003

198. Katoh M, Katoh M. Identification and characterization of TPARM gene in silico. Int J Oncol, 23:1213-1217, 2003

199. Katoh M, Katoh M. Bioinformatics for oncogenomic target identification. Genome Informatics, 14:348-349, 2003

200. Katoh M, Katoh M. Comparative genomics between Drosophila and human. Genome Informatics, 14:587-588, 2003

201. Katoh M, Katoh M. Identification and characterization of human PPFIA4 gene in silico. Int J Mol Med, 12:1009-1014, 2003

202. Katoh M, Katoh M. Identification and characterization of human GRID2IP gene and rat Grid2ip gene in silico. Int J Mol Med, 12:1015-1019, 2003

203. Katoh M, Katoh M. Identification and characterization of human KIAA1391 and mouse Kiaa1391 genes encoding novel RhoGAP family proteins with RA domain and ANXL repeats. Int J Oncol, 23:1471-1476, 2003

204. Katoh M, Katoh M. Identification and characterization of human LL5A gene and mouse Ll5a gene in silico. Int J Oncol, 23:1477-1483, 2003

205. Heller RS, Klein T, Ling Z, Heimberg H, Katoh M, Madsen OD, Serup P. Expression of Wnt, Frizzled, sFRP, and DKK genes in adult human pancreas. Gene Expr, 11:141-147, 2003

12. Radiobiology Division

206. Taya Y, Nakajima K, Yoshizawa-Kumagaye K, Tamai K. Generation and application of phospho-specific antibodies for p53 and pRB. In: Wafik E-D (ed), Methods in Molecular Biology. USA, Humana Press Inc., pp 17-26, 2003

207. Oguchi K, Takagi M, Tsuchida R, Taya Y, Ito E, Isoyama K, Ishii E, Zannini L, Delia D, Mizutani S. Missense mutation and defective function of ATM in a childhood acute leukemia patient with MLL gene rearrangement. Blood, 101:3622-3627, 2003

208. Shinozaki T, Nota A, Taya Y, Okamoto K. Functional role of Mdm2 phosphorylation by ATR in attenuation of p53 nuclear export. Oncogene, 22:8870-8880, 2003

209. Gaiddon C, Lokshin M, Gross I, Levasseur D, Taya Y, Loeffler JP, Prives C. Cyclin-dependent kinases phosphorylate p73 at threonine 86 in a cell cycle-dependent manner and negatively regulate p73. J Biol Chem, 278:27421-27431, 2003

210. Huang S, Qu LK, Cuddihy AR, Ragheb R, Taya Y, Koromilas AE. Protein kinase inhibitor 2-aminopurine overrides multiple genotoxic stress-induced cellular pathways to promote cell survival. Oncogene, 22:3721-3733, 2003

13. Carcinogenesis Division

211. Kaneda A, Takai D, Kaminishi M, Okochi E, Ushijima T. Methylation-sensitive representational difference analysis and its application to cancer research. Ann N Y Acad Sci, 983:131-141, 2003

212. Asada K, Miyamoto K, Fukutomi T, Tsuda H, Yagi Y, Wakazono K, Oishi S, Fukui H, Sugimura T, Ushijima T. Reduced expression of GNA11 and silencing of MCT1 in human breast cancers. Oncology, 64:380-388, 2003

213. Miyamoto K, Asada K, Fukutomi T, Okochi E, Yagi Y, Hasegawa T, Asahara T, Sugimura T, Ushijima T. Methylation-associated silencing of heparan sulfate D-glucosaminyl 3-O-sulfotransferase-2 (3-OST-2) in human breast, colon, lung and pancreatic cancers. Oncogene, 22:274-280, 2003

214. Ushijima T, Watanabe N, Okochi E, Kaneda A, Sugimura T, Miyamoto K. Fidelity of the methylation pattern and its variation in the genome. Genome Res, 13:868-874, 2003

215. Yamashita S, Nomoto T, Ohta T, Ohki M, Sugimura T, Ushijima T. Differential expression of genes related to levels of mucosal cell proliferation among multiple rat strains using oligonucleotide microarrays. Mamm Genome, 14:845-852, 2003

216. Abe M, Yamashita S, Kuramoto T, Hirayama Y, Tsukamoto T, Ohta T, Tatematsu M, Ohki M, Takato T, Sugimura T, Ushijima T. Global expression analysis of N-methyl-N'-nitro-N-nitrosoguanidine-induced rat stomach carcinomas using oligonucleotide microarrays. Carcinogenesis, 24:861-867, 2003

217. Tsukamoto T, Yamamoto M, Ogasawara N, Ushijima T, Nomoto T, Fujita H, Matsushima T, Nozaki K, Cao X, Tatematsu M. b-Catenin mutations and nuclear accumulation during progression of rat stomach adenocarcinomas. Cancer Sci, 94:1046-1051, 2003

218. Huang H, Ushijima T, Nagao M, Sugimura T, Ohgaki H. b-catenin mutations in liver tumors induced by 2-amino-3,4-dimethylimidazo[4,5-f]quinoline in CDF1 mice. Cancer Lett, 198:29-35, 2003

219. Takahashi S, Suzuki S, Inaguma S, Ikeda Y, Cho YM, Hayashi N, Inoue T, Sugimura Y, Nishiyama N, Fujita T, Chao J, Ushijima T, Shirai T. Down-regulated expression of prostasin in high-grade or hormone-refractory human prostate cancers. Prostate, 54:187-193, 2003

14. Section for Studies on Metastasis

220. Hirai K, Sasaki H, Sakamoto H, Takeshita F, Asano K, Kubota Y, Ochiya T, Terada M. Antisense oligodeoxynucleotide against HST-1/FGF-4 suppresses tumorigenicity of an orthotopic model for human germ cell tumor in nude mice. J Gene Med, 5:951-957, 2003

221. Sano A, Maeda M, Nagahara S, Ochiya T, Honma K, Itoh H, Miyata T, Fujioka K. Atelocollagen for protein and gene delivery. Adv Drug Deliv Rev, 55:1651-1677, 2003

222. Yamamoto H, Quinn G, Asari A, Yamanokuchi H, Teratani T, Terada M, Ochiya T. Differentiation of embryonic stem cells into hepatocytes: biological functions and therapeutic application. Hepatology, 37:983-993, 2003

15. Section for Studies on Host-Immune Response

223. Furuhata S, Ide H, Miura Y, Yoshida T, Aoki K. Development of a prostate-specific promoter for gene therapy against androgen-independent prostate cancer. Mol Ther, 7:366-374, 2003

224. Hatanaka K, Ohnami S, Yoshida K, Miura Y, Aoyagi K, Sasaki H, Asaka M, Terada M, Yoshida T, Aoki K. A simple and efficient method for constructing an adenoviral cDNA expression library. Mol Ther, 8:158-166, 2003

17. Cancer Prevention Basic Research Project

225. Morisawa T, Mizuno T, Ohe T, Watanabe T, Hirayama T, Nukaya H, Shiozawa T, Terao Y, Sawanishi H, Wakabayashi K. Levels and behavior of 2-phenylbenzotoriazole-type mutagens in the effluent of a sewage treatment plant. Mutat Res, 534:123-132, 2003

226. Watanabe T, Hasei T, Takahashi Y, Otake S, Murahashi T, Takamura T, Hirayama T, Wakabayashi K. Mutagenic activity and quantification of nitroarenes in surface soil in the Kinki region of Japan. Mutat Res, 538:121-131, 2003

227. Murahashi T, Watanabe T, Otake S, Hattori Y, Takamura T, Wakabayashi K, Hirayama T. Determination of 3-nitrobenzanthrone in surface soil by normal-phase high-performance liquid chromatography with fluorescence detection. J Chromatogr A, 992:101-107, 2003

228. Takamura-Enya T, Ishihara J, Tahara S, Goto S, Totsuka Y, Sugimura T, Wakabayashi K. Analysis of estrogenic activity of foodstuffs and cigarette smoke condensates using a yeast estrogen screening method. Food Chem Toxicol, 41:543-550, 2003

229. Takamura-Enya T, Ishikawa S, Mochizuki M, Wakabayashi K. A practical approach for the chemical synthesis of 2'-deoxyguanosine-C8 adducts with mutagenic/carcinogenic amino- or nitro-arenes. Tetrahedron Lett, 44:5969-5973, 2003

230. Masumura K, Totsuka Y, Wakabayashi K, Nohm T. Potent genotoxicity of aminophenylnorharman, formed from non-mutagenic norharman and aniline, in the liver of gpt delta transgenic mouse. Carcinogenesis, 24:1985-1993, 2003

231. Shibata H, Iimuro M, Uchiya N, Kawamori T, Nagaoka M, Ueyama S, Hashimoto S, Yokokura T, Sugimura T, Wakabayashi K. Preventive effects of cladosiphon fucoidan against Helicobacter pylori infection in Mongolian gerbils. Helicobacter, 8:59-65, 2003

232. Matsubara S, Shibata H, Ishikawa F, Yokokura T, Takahashi M, Sugimura T, Wakabayashi K. Suppression of Helicobacter pylori-induced gastritis by green tea extract in Mongolian gerbils. Biochem Biophys Res Commun, 310:715-719, 2003

233. Kawamori T, Uchiya N, Sugimura T, Wakabayashi K. Enhancement of colon carcinogenesis by prostaglandin E2 administration. Carcinogenesis, 24:985-990, 2003

234. Kitamura T, Itoh M, Noda T, Tani K, Kobayashi M, Maruyama T, Kobayashi K, Ohuchida S, Sugimura T, Wakabayashi K. Combined effects of prostaglandin E receptor subtype EP1 and subtype EP4 antagonists on intestinal tumorigenesis in adenomatous polyposis coli gene knockout mice. Cancer Sci, 94:618-621, 2003

235. Niho N,Takahashi M, Kitamura T, Shoji Y, Itoh M, Noda T, Sugimura T, Wakabayashi K. Concomitant suppression of hyperlipidemia and intestinal polyp formation in Apc-deficient mice by peroxisome proliferator-activated receptor ligands. Cancer Res, 63:6090-6095, 2003

236. Niho N, Takahashi M, Shoji Y, Takeuchi Y, Matsubara S, Sugimura T, Wakabayashi K. Dose-dependent suppression of hyperlipidemia and intestinal polyp formation in Min mice by pioglitazone, a PPARg ligand. Cancer Sci, 94:960-964, 2003

237. Takahashi M, Mutoh M, Shoji Y, Kamanaka Y, Naka M, Maruyama T, Sugimura T, Wakabayashi K. Transfection of K-rasAsp12 cDNA markedly elevates IL-1b- and lipopolysaccharide-mediated inducible nitric oxide synthase expression in rat intestinal epithelial cells. Oncogene, 22:7667-7676, 2003

238. Mutoh M, Matsui H, Takahashi M, Takamura-Enya T, Wakabayashi K. Suppression of transcriptional activity of gene promoter for cyclooxygenase-2 and inducible nitric oxide synthase in colon cancer cells. In: Shahidi F, Ho C-T, Watanabe S, Osawa T (eds), Food Factors in Health Promotion and Disease Prevention. USA, American Chemical Society, pp 100-112, 2003

239. Yoshida K, Tanaka T, Kohno H, Sakata K, Kawamori T, Mori H, Wakabayashi K. A COX-2 inhibitor, nimesulide, inhibits chemically-induced rat tongue carcinogenesis through suppression of cell proliferation activity and COX-2 and iNOS expression. Histol Histopathol, 18:39-48, 2003

240. Furukawa F, Nishikawa A, Lee I-S, Kanki K, Umemura T, Okazaki K, Kawamori T, Wakabayashi K, Hirose M. A cyclooxygenase-2 inhibitor, nimesulide, inhibits postinitiation phase of N-nitrosobis(2-oxopropyl)amine-induced pancreatic carcinogenesis in hamsters. Int J Cancer, 104:269-273, 2003

241. Matsushima-Hibiya Y, Watanabe M, Hidari KI-PJ, Miyamoto D, Suzuki Y, Kasama T, Kanazawa T, Koyama K, Sugimura T, Wakabayashi K. Identification of glycosphingolipid receptors for pierisin-1, a guanine-specific ADP-ribosylating toxin from the cabbage butterfly. J Biol Chem, 278:9972-9978, 2003

242. Totsuka Y, Kawanishi M, Nishigaki R, Matsukawa K, Yagi T, Takamura-Enya T, Watanabe M, Sugimura T, Wakabayashi K. Analysis of HPRT and supF mutations caused by pierisin-1, a guanine specific ADP-ribosylating toxin derived from the cabbage butterfly. Chem Res Toxicol, 16:945-952, 2003

18. Cancer Proteomics Project

243. Yamada T, Mori Y, Hayashi R, Takada M, Ino Y, Naishiro Y, Kondo T, Hirohashi S. Suppression of intestinal polyposis in Mdr1-deficient ApcMin/+ Mice. Cancer Res, 63:895-901, 2003

244. Seike M, Kondo T, Mori Y, Gemma A, Kudoh S, Sakamoto M, Yamada T, Hirohashi S. Proteomic analysis of intestinal epithelial cells expressing stabilized b-catenin. Cancer Res, 63:4641-4647, 2003

245. Kondo T, Seike M, Mori Y, Fujii K, Yamada T, Hirohashi S. Application of sensitive fluorescent dyes in linkage of laser microdissection and two-dimensional gel electrophoresis as a cancer proteomic study tool. Proteomics, 3:1758-1766, 2003

19. Cancer Transcriptome Project

246. Yagi T, Morimoto A, Eguchi M, Hibi S, Sako M, Ishii E, Mizutani S, Imashuku S, Ohki M, Ichikawa H. Identification of a gene expression signature associated with pediatric AML prognosis. Blood, 102:1849-1856, 2003

247. Yasuda J, Tsuchiya A, Yamada T, Sakamoto M, Sekiya T, Hirohashi S. Nemo-like kinase induces apoptosis in DLD-1 human colon cancer cells. Biochem Biophys Res Commun, 308:227-233, 2003

20. DNA Methylation and Genome Function Project

248. Koizume S, Sekiya T, Shiraishi M. Specific methylation status of the entire CpG island is not a prerequisite for the formation of an inactive chromatin at the promoter region in cancer cells. Biol Pharm Bull, 26:127-128, 2003

249. Koizume S, Tachibana K, Shiraishi M. Treatment of tumor cells with histone deacetylase inhibitors results in altered recruitment of methyl-CpG binding proteins to a methylated CpG island. Biol Chem, 384:787-790, 2003

21. Tumor Endocrinology Project

250. Inagaki M, Aoyagi T, Nomura A, Yokoo H, Akabane M, Kawata A, Nakano S, Chiba A, Fujii T, Sakurai H, Tsukada T, Takahashi M. Surgical approach to tumor recurrence and metastatic lesions of the liver in a patient with malignant endocrine tumors of the pancreas: case report. J Hepatobiliary Pancreat Surg, 10:325-328, 2003

251. Hanada T, Toshinai K, Kajimura N, Nara-Ashizawa N, Tsukada T, Hayashi Y, Osuye K, Kangawa K, Matsukura S, Nakazato M. Anti-cachectic effect of ghrelin in nude mice bearing human melanoma cells. Biochem Biophys Res Commun, 301:275-279, 2003

22. Tumor Suppression and Functional Genomics Project

252. Fukami T, Fukuhara H, Kuramochi M, Maruyama T, Isogai K, Sakamoto M, Takamoto S, Murakami Y. Promoter methylation of the TSLC1 gene in advanced lung tumors and various cancer cell lines. Int J Cancer, 107:53-59, 2003

253. Ito T, Shimada Y, Hashimoto Y, Kaganoi J, Kan T, Watanabe G, Murakami Y, Imamura M. Involvement of TSLC1 in progression of esophageal squamous cell carcinoma. Cancer Res, 63:6320-6326, 2003

254. Fukuhara H, Masuda M, Yageta M, Fukami T, Kuramochi M, Maruyama T, Kitamura T, Murakami Y. Association of a lung tumor suppressor TSLC1 with MPP3, a human homologue of Drosophila tumor suppressor Dlg. Oncogene, 22:6160-6165, 2003

255. Mao X, Seidlitz E, Ghosh K, Murakami Y, Ghosh HP. The Cytoplasmic domain is critical to the tumour suppressor activity of TSLC1 in non-small cell lung cancer. Cancer Res, 63:7979-7985, 2003

256. Fukami T, Satoh H, Williams Y, Masuda M, Fukuhara H, Maruyama T, Yageta M, Kuramochi M, Takamoto S, Murakami Y. Isolation of the mouse Tsll1 and Tsll2 genes, orthologues of the human TSLC1-like genes 1 and 2 (TSLL1 and TSLL2). Gene, 323:11-18, 2003

23. Pathology Division

257. Watanabe I, Hasebe T, Sasaki S, Konishi M, Inoue K, Nakagohri T, Oda T, Mukai K, Kinoshita T. Advanced pancreatic ductal cancer: fibrotic focus and b-catenin expression correlate with outcome. Pancreas, 26:326-333, 2003

258. Hasebe T, Sasaki S, Imoto S, Ochiai A. Histological characteristics of tumors in blood vessels play an important role in tumor progression of invasive ductal carcinoma of the breast. Cancer Sci, 94:158-165, 2003

259. Hasebe T, Sasaki S, Imoto S, Ochiai A. Significance of nodal metastatic tumor characteristics in nodal metastasis and prognosis of patients with invasive ductal carcinoma of the breast. Cancer Sci, 94:181-187, 2003

260. Hasebe T, Sasaki S, Imoto S, Ochiai A. Tumor cells in lymph vessels and lymph nodes closely associated with nodal metastasis by invasive ductal carcinoma of the breast. Cancer Sci, 94:508-514, 2003

261. Ishii G, Sangai T, Oda T, Aoyagi Y, Hasebe T, Kanomata N, Endoh Y, Okumura C, Okuhara Y, Magae J, Emura M, Ochiya T, Ochiai A. Bone-marrow-derived myofibroblasts contribute to the cancer-induced stromal reaction. Biochem Biophys Res Commun, 309:232-240, 2003

262. Yonou H, Kanomata N, Goya M, Kamijo T, Yokose T, Hasebe T, Nagai K, Hatano T, Ogawa Y, Ochiai A. Osteoprotegerin/osteoclastogenesis inhibitory factor decreases human prostate cancer burden in human adult bone implanted into nonobese diabetic/severe combined immunodeficient mice. Cancer Res, 63:2096-2102, 2003

263. Hironaka S, Ohtsu A, Boku N, Muto M, Nagashima F, Saito H, Yoshida S, Nishimura M, Haruno M, Ishikura S, Ogino T, Yamamoto S, Ochiai A. Nonrandomized comparison between definitive chemoradiotherapy and radical surgery in patients with T2-3Nany M0 squamous cell carcinoma of the esophagus. Int J Radiat Oncol Biol Phys, 57:425-433, 2003

264. Zhang S-C, Miyamoto S, Kamijo T, Hayashi R, Hasebe T, Ishii G, Fukayama M, Ochiai A. Intratumor microvessel density in biopsy specimens predicts local response of hypopharyngeal cancer to radiotherapy. Jpn J Clin Oncol, 33:613-619, 2003

265. Funai K, Yokose T, Ishii G, Araki K, Yoshida J, Nishimura M, Nagai K, Nishiwaki Y, Ochiai A. Clinicopathologic characteristics of peripheral squamous cell carcinoma of the lung. Am J Surg Pathol, 27:978-984, 2003

266. Araki K, Ishii G, Yokose T, Nagai K, Funai K, Kodama K, Nishiwaki Y, Ochiai A. Frequent overexpression of the c-kit protein in large cell neuroendocrine carcinoma of the lung. Lung Cancer, 40:173-180, 2003

267. Sano Y, Kuga R, Fu KI, Yoshino T, Yoshida S, Ochiai A, Fujii T. Superficially elevated colonic adenoma changed to undetectable configuration on ordinary endoscopy during treatment with preferential cyclooxygenase-2 inhibitor. J Gastroenterol, 38:909-910, 2003

268. Yoh K, Goto K, Ishii G, Niho S, OhmatsuH, Kubota K, Kakinuma R, Nagai K, SugaM, Nishiwaki Y. Week chemotherapy with cisplatin, vincristine, doxorubicin, and etoposide is an effective treatment for advanced thymic carcinoma. Cancer, 98:926-931, 2003

269. Nakahashi C, Oda T, Kinoshita T, Ueda T, Konishi M, Nakagohri T, Inoue K, Furuse J, Ochiai A, Ohkohchi N. The impact of liver metastasis on mortality in patients initially diagnosed with locally advanced or resectable pancreatic cancer. Int J Gastrointest Cancer, 33:155-164, 2003

270. Takamochi K, Yokose T, Yoshida J, Nishimura M, Ohmatsu H, Nagai K, Nishiwaki Y, Ochiai A. Calcification in large cell neuroendocrine carcinoma of the lung. Jpn J Clin Oncol, 33:10-13, 2003

271. Teramachi K, Kanomata N, Hasebe T, Ishii G, Sugito M, Ochiai A. Carcinosarcoma (pure endocrine cell carcinoma with sarcoma components) of the stomach. Pathol Int, 53:552-556, 2003

24. Epidemiology and Biostatistics Division

272. Tsugane S, Sasaki S, Kobayashi M, Tsubono Y, Akabane M. Validity and reproducibility of the self-administered food frequency questionnaire in the JPHC Study Cohort I: study design, conduct and participant profiles. J Epidemiol, 13:s2-s12, 2003

273. Sasaki S, Kobayashi M, Ishihara J, Tsugane S. Self-administered food frequency questionnaire used in the 5-year follow-up survey of the JPHC Study: questionnaire structure, computation algorithms, and area-based mean intake. J Epidemiol, 13:s13-s22, 2003

274. Sasaki S, Takahashi T, Iitoi Y, Iwase Y, Kobayashi M, Ishihara J, Akabane M, Tsugane S. Food and nutrient intakes assessed with dietary records for the validation study of a self-administered food frequency questionnaire in JPHC Study Cohort I. J Epidemiol, 13:s23-s50, 2003

275. Tsugane S, Kobayashi M, Sasaki S. Validity of the self-administered food frequency questionnaire used in the 5-year follow-up survey of the JPHC Study Cohort I: comparison with dietary records for main nutrients. J Epidemiol, 13:s51-s56, 2003

276. Sasaki S, Kobayashi M, Tsugane S. Validity of a self-administered food frequency questionnaire used in the 5-year follow-up survey of the JPHC Study Cohort I: comparison with dietary records for food groups. J Epidemiol, 13:s57-s63, 2003

277. Kobayashi M, Sasaki S, Kawabata T, Hasegawa K, Tsugane S. Validity of a self-administered food frequency questionnaire used in the 5-year follow-up survey of the JPHC Study Cohort I to assess fatty acid intake: comparison with dietary records and serum phospholipid level. J Epidemiol, 13:s64-s81, 2003

278. Kobayashi M, Sasaki S, Tsugane S. Validity of a self-administered food frequency questionnaire used in the 5-year follow-up survey of the JPHC Study Cohort I to assess carotenoids and vitamin C intake: comparison with dietary records and blood level. J Epidemiol, 13:s82-s91, 2003

279. Karita K, Sasaki S, Ishihara J, Tsugane S. Validity of a self-administered food frequency questionnaire used in the 5-year follow-up survey of the JPHC Study to assess selenium intake: comparison with dietary records and blood levels. J Epidemiol, 13:s92-s97, 2003

280. Iso H, Moriyama Y, Yoshino K, Sasaki S, Ishihara J, Tsugane S. Validity of the self-administered food frequency questionnaire used in the 5-year follow-up survey for the JPHC Study to assess folate, vitamin B6 and B12 intake: comparison with dietary records and blood level. J Epidemiol, 13:s98-s101, 2003

281. Sasaki S, Ishihara J, Tsugane S. Validity of a self-administered food frequency questionnaire in the 5-year follow-up survey of the JPHC Study Cohort I to assess sodium and potassium intake: comparison with dietary records and 24-hour urinary excretion level. J Epidemiol, 13:s102-s105, 2003

282. Sasaki S, Matsumura Y, Ishihara J, Tsugane S. Validity of a self-administered food frequency questionnaire used in the 5-year follow-up survey of the JPHC Study Cohort I to assess dietary fiber intake: comparison with dietary records. J Epidemiol, 13:s106-s114, 2003

283. Sasaki S, Ishihara J, Tsugane S. Reproducibility of a self-administered food frequency questionnaire used in the 5-year follow-up survey of the JPHC Study Cohort I to assess food and nutrient intake. J Epidemiol, 13:s115-s124, 2003

284. Tsubono Y, Kobayashi M, Sasaki S, Tsugane S. Validity and reproducibility of a self-administered food frequency questionnaire used in the baseline survey of the JPHC Study Cohort I. J Epidemiol, 13:s125-s133, 2003

285. Fahey MT, Sasaki S, Kobayashi M, Akabane M, Tsugane S. Seasonal misclassification error and magnitude of true between-person variation in dietary nutrient intake: a random coefficients analysis and implications for the Japan Public Health Center (JPHC) Cohort Study. Public Health Nutr, 6:385-391, 2003

286. Iwasaki M, Otani T, Yamamoto S, Inoue M, Hanaoka T, Sobue T, Tsugane S, the JPHC Study Group. Background characteristics of basic health examination participants: the JPHC Study Baseline Survey. J Epidemiol, 13:216-225, 2003

287. Otani T, Iwasaki M, Yamamoto S, Sobue T, Hanaoka T, Inoue M, Tsugane S. Alcohol consumption, smoking, and subsequent risk of colorectal cancer in middle-aged and elderly Japanese men and women: Japan Public Health Center-based Prospective Study. Cancer Epidemiol Biomarkers Prev 12:1492-1500, 2003

288. Isogawa A, Noda M, Takahashi Y, Kadowaki T, Tsugane S. Coffee consumption and risk of type 2 diabetes mellitus. Lancet, 361:703-704, 2003

289. Montani A, Sasazuki S, Inoue M, Higuchi K, Arakawa T, Tsugane S. Food/nutrient intake and risk of atrophic gastritis among the Helicobacter pylori-infected population of northeastern Japan. Cancer Sci, 94:372-377, 2003

290. Kim MK, Sasazuki S, Sasaki S, Okubo S, Hayashi M, Tsugane S. Effect of five-year supplementation of vitamin C on serum vitamin C concentration and consumption of vegetables and fruits in middle-aged Japanese: a randomized controlled trial. J Am Coll Nutr, 22:208-216, 2003

291. Sasazuki S, Sasaki S, Tsubono Y, Okubo S, Hayashi M, Kakizoe T, Tsugane S. The effect of 5-year vitamin C supplementation on serum pepsinogen level and Helicobacter pylori infection. Cancer Sci, 94:378-382, 2003

292. Takashashi Y, Sasaki S, Takahashi M, Okubo S, Hayashi M, Tsugane S. A population-based dietary intervention trial in a high-risk area for stomach cancer and stroke: changes in intakes and related biomarkers. Prev Med, 37:432-441, 2003

293. Sasaki S, Takahashi Y, Kim M-K. Tailored dietary counseling using self-administered diet history questionnaire is effective for health promotion: Japanese experience. J Community Nutrition, 5:112-119, 2003

294. Tatemichi M, Hamada GS, Nishimoto IN, Kowalski LP, Iriya K, Rodrigues JJG, Tsugane S. Ethnic difference in serology of Helicobacter pylori CagA between Japanese and non-Japanese Brazilians for non-cardia gastric cancer. Cancer Sci, 94:64-69, 2003

295. Pan G, Hanaoka T, Ichiba M, Zhang J, Yamano Y, Hara K, Takahashi K. Effects of polymorphisms of CYP1A1, GSTM1 and NAT2 on aromatic DNA adduct in coke-oven workers. J UOEH, 25:111-126, 2003

296. Zhang J, Ichiba M, Hanaoka T, Pan G, Yamano Y, Hara K, Takahashi K, Tomokuni K. Leukocyte 8-hydroxydeoxyguanosine and aromatic DNA adduct in coke-oven workers with polycyclic aromatic hydrocarbon exposure. Int Arch Occup Environ Health, 76:499-504, 2003

297. Hara M, Hanaoka, T, Kobayashi, M, Otani, T, Adachi, H. Y, Montani A, Natsukawa S, Shaura K, Koizumi Y, Kasuga Y, Matsuzawa T, Ikekawa T, Sasaki S, Tsugane S. Cruciferous vegetables, mushrooms, and gastrointestinal cancer risks in a multicenter, hospital-based case-control study in Japan. Nutrition and Cancer, 46:138-147, 2003

298. Yoshimura K, Hanaoka T, Ohnami S, Ohnami S, Kohno T, Liu Y, Yoshida T, Sakamoto H, Tsugane S. Allele frequencies of single nucleotide polymorphisms (SNPs) in 40 candidate genes for gene-environment studies on cancer: data from population-based Japanese random samples. J Hum Genet, 48:654-658, 2003

299. Hanaoka T, Takai O, Takahashi K, Tsugane S. Chip ligating human genomic DNA serves as storage material and template for polymerase chain reaction. Biotechnol Lett, 25:509-512, 2003

300. Inoue M, Tominaga S. Probabilities of developing cancer over the life span of a Japanese-update. Asia Pacific J Cancer Prev, 4:199-202, 2003

301. Takezaki T, Inoue M, Kataoka H, Ikeda S, Yoshida M, Ohashi Y, Tajima K, Tominaga S. Diet and lung cancer risk from a 14-year population-based prospective study in Japan: with special reference to fish consumption. Nutr Cancer, 45:160-167, 2003

302. Kim J, Kim D-H, Ahn Y-O, Tokudome Y, Hamajima N, Inoue M, Tajima K. Reproducibility of a food frequency questionnaire in Koreans. Asia Pacific J Cancer Prev, 4:253-257, 2003 25. Investigative Treatment Division

25. Investigative Treatment Division

303. Matsumura Y. An interim analysis of phase I Clinical Trial of MCC-465, a Doxorubicin (DXR) encapsulated in PEG-immunoliposome, in patients with metastatic stomach cancer. In: Maeda H (ed), Polymer Drugs in the Clinical Stage. USA, Kluwer Academic/Plenum Publishers, pp 179-193, 2003

304. Nishiyama N, Koizumi F, Okazaki S, Matsumura Y, Nishio K, Kataoka K. Diffirenitial gene expression profile between PC-14 cells treated with free cisplatin and cisplatin-lncorrated polymeric micelles. Bioconjugate Chemistry, 14:449-457, 2003

305. Ishii Y, Ogura T, Tatemichi M, Fujisawa H, Otsuka F, Esumi H. Induction of matrix metalloproteinase gene transcription by nitric oxide and mechanisms of MMP-1 gene induction in human melanoma cell lines. Int J Cancer, 103:161-168, 2003

306. Kato S, Esumi H, Hirano A, Kato M, Asayama K, Ohama E. Immunohistochemical expression of inducible nitric oxide synthase (iNOS) in human brain tumors: relationships of iNOS to superoxide dismutase (SOD) proteins (SOD1 and SOD2), Ki-67 antigen (MIB-1) and p53 protein. Acta Neuropathol, 105:333-340, 2003

307. Kimura H, Esumi H. Reciprocal regulation between nitric oxide and vascular endothelial growth factor in angiogenesis. Acta Biochim Pol, 50:49-59, 2003

308. Tatemichi M, Ogura T, Sakurazawa N, Nagata H, Sugita M, Esumi H. Inducible nitric oxide synthase activity induced by sodium chloride solution prolongs luminal pH elevation in rat and mouse stomachs. J Gastroenterol Hepatol, 18:1039-1046, 2003

309. Tatemichi M, Ogura T, Sakurazawa N, Nagata H, Sugita M, Esumi H. Roles of inducible nitric oxide synthase in the development and healing of experimentally induced gastric ulcers. Intl J Exp Pathol, 84:213-220, 2003

310. Suzuki A, Kusakai G, Kishimoto A, Lu J, Ogura T, Lavin MF, Esumi H. Identification of a novel protein kinase mediating Akt survival signaling to the ATM protein. J Biol Chem, 278:48-53, 2003

311. Suzuki A, Kusakai G, Kishimoto A, Lu J, Ogura T, Esumi H. ARK5 suppresses the cell death induced by nutrient starvation and death receptors via inhibition of caspase 8 activation, but not by chemotherapeutic agents or UV irradiation. Oncogene, 22:6177-6182, 2003

312. Suzuki A, Kusakai G, Kishimoto A, Minegichi Y, Ogura T, Esumi H. Induction of cell-cell detachment during glucose starvation through F-actin conversion by SNARK, the fourth member of the AMP-activated protein kinase catalytic subunit family. Biochem Biophys Res Commun, 311:156-161, 2003

313. Yokoyama T, Yokoyama A, Kato H, Tsujinaka T, Muto M, Omori T, Haneda T, Kumagai Y, Igaki H, Yokoyama M, Watanabe H, Yoshimizu H. Alcohol flushing, alcohol and aldehyde dehydrogenase genotypes, and risk for esophageal squamous cell carcinoma in Japanese men. Cancer Epidemiol Biomarkers Prev, 12:1227-1233, 2003

26. Psycho-Oncology Division

314. Kagaya A, Okamura H, Takebayashi M, Akechi T, Morinobu S, Yamawaki S, Uchitomi Y. Mood disturbance and neurosteroids in women with breast cancer. Stress and Health, 19:227-231, 2003

315. Akechi T, Nakano T, Akizuki N, Okamura M, Sakuma K, Nakanishi T, Yoshikawa E, Uchitomi Y. Somatic symptoms for diagnosing major depression in cancer patients. Psychosomatics, 44:244-248, 2003

316. Uchitomi Y, Akechi T, Fujimori M, Okamura M, Ooba A. Mental adjustment after surgery for non-small cell lung cancer. Palliat Support Care, 1:61-70, 2003

317. Uchitomi Y, Mikami I, Nagai K, Nishiwaki Y, Akechi T, Okamura H. Depression and psychological distress in patients during the year after curative resection of non-small-cell lung cancer. J Clin Oncol, 21:69-77, 2003

318. Akizuki N, Akechi T, Nakanishi T, Yoshikawa E, Okamura M, Nakano T, Murakami Y, Uchitomi Y. Development of a brief screening interview for adjustment disorders and major depression in patients with cancer. Cancer, 97:2605-2613, 2003

319. Akechi T, Sakuma K, Okamura M, Akizuki N, Oba A, Nakano T, Uchitomi Y. Trauma in a Nurse after patient suicide. Psychosomatics, 44:522-523, 2003

320. Matsuoka Y, Yamawaki S, Inagaki M, Akechi T, Uchitomi Y. A volumetric study of amygdala in cancer survivors with intrusive recollections. Biol Psychiatry, 54:736-743, 2003

321. Taniguchi K, Akechi T, Suzuki S, Mihara M, Uchitomi Y. Performance status 1 predicts psychological response in female, but not male, ambulatory cancer patients. Support Care Cancer, 11:465-471, 2003

322. Taniguchi K, Akechi T, Suzuki S, Mihara M, Uchitomi Y. Lack of marital support and poor psychological responses in male cancer patients. Support Care Cancer, 11:604-610, 2003

323. Okamura H, Fukui S, Nagasaka Y, Koike M, Uchitomi Y. Psychoeducational intervention for patients with primary breast cancer and patient satisfaction with information. Breast Cancer Res Treat, 80:331-338, 2003

324. Fukui S, Koike M, Ooba A, Uchitomi Y. The effect of a psychosocial group intervention on loneliness and social support for Japanese women with primary breast cancer. Oncol Nurs Forum, 30:823-830, 2003

325. Fujimori M, Oba A, Koike M, Okamura M, Akizuki N, Kamiya M, Akechi T, Sakano Y, Uchitomi Y. Communication skills training for Japanese oncologists on how to break bad news. J Cancer Educ, 18:194-201, 2003

326. Akechi T, Nakano T, Akizuki N, Nakanishi T, Yoshikawa E, Okamura H, Uchitomi Y. Psychiatric evaluation of competency in cancer patients. Int J Psychiatry Clin Pract, 7:101-106, 2003

327. Morita T, Hirai K, Akechi T, Uchitomi Y. Similarity and difference among standard medical care, palliative sedation therapy, and euthanasia: a multidimensional scaling analysis on physicians' and the general population's opinions. J Pain Symptom Manage, 25:357-362, 2003

328. Kohara H, Ueoka H, Aoe K, Maeda T, Takeyama H, Saito R, Shima Y, Uchitomi Y. Effect of nebulized furosemide in terminally ill cancer patients with dyspnea. J Pain Symptom Manage, 26:962-967, 2003

329. Akechi T, Okamura H, Nishiwaki Y, Uchitomi Y. Psychiatric disorders and associated and predictive factors in patients with unresectable nonsmall cell lung carcinoma; authors'reply. Cancer, 97:3129, 2003

330. Okuyama T, Wang XS, Akechi T, Mendoza TR, Hosaka T, Cleeland CS, Uchitomi Y. Validation study of the Japanese version of the Brief Fatigue Inventory. J Pain Symptom Manage, 25:106-117, 2003

331. Okuyama T, Wang XS, Akechi T, Mendoza T R, Hosaka T, Cleeland CS, Uchitomi Y. Japanese version of the M.D. Anderson Symptom Inventory; a validation study. J Pain Symptom Manage, 26:1093-1104, 2003