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Project Index Arranged by Category

Chemical and radiation carcinogenesis

Susceptibility to Colon Carcinogenesis

Multistep Genetic Alterations in Colon Carcinogenesis Induced by PhIP

PolyADP-ribosylation and Carcinogenesis

Analysis of the Carcinogenic Process Using Transgenic Rats

Risk Assessment and Other Studies

Cancer Susceptibility and the Rat Genome

Environmental Factors and Cancer

Mutagens in River Water and Surface Soil

Mutagens Formed from Norharman with Aromatic Amines

Cytotoxic Factors Present in Butterflies

Chemoprevention

Anti-carcinogenesis

Prevention of Carcinogenesis and Anti-metastasis by Bovine Lactoferrin (bLF)

Search for Cancer Suppressing Substances

Viral carcinogenesis

Immortalization of Human Cells by HPV

HCV RNA Replicon and Application of an LCM-array for Cancer

Oncogenes and suppressor genes

Molecular Basis of Multistage Lung Carcinogenesis

Functional Analysis of Cancer-related Genes

Identification and Characterization of p53-target Genes

Molecular Mechanism of Stop Codon Recognition

Functional Analysis of Normal and Activated Ret Oncogenes in Human Cancers

PML Interacts with AML1 and Regulates Transcription of Their Target Genes

PU.1 Regulates Expression of SHIP in Hematopoietic Cells

Rearrangement of MOZ in Pediatric tMDS with t(2;8)(p23;p11)

Expression Analysis of The Gasdermine Gene Family

Characterization of The Biological Function of The SYT-SSX1 Gene in Synovial Sarcomas

Medical Bioinformatics

Methods for Generation of Phospho-specific Antibodies

Mutation of ATM in MLL

Phosphorylation of Mdm2 by ATR

Phosphorylation of p73 by CDK

2-Aminopurine and p53

Genome-Wide Detection of Chromosomal Imbalances in Tumors

Mechanism to Regulate Neutrophilic Differentiation

Analysis of Effect of NLK on Cell Growth

Multiple Endocrine Neoplasia Type 1

Involvement of Aberrant Splicing in Tumorigenesis

Characterization of the TSLC1 Protein and Its Cascade of Tumor Suppression

Towards the Elucidation of the TSLC1 Function in Model Animals

Tumor biology, invasion and metastasis

Mechanisms of Cancer Invasion and Metastasis

Molecular Background of the Biological Characteristics of Human Cancers

Molecular Mechanism for Maintenance of G-rich Short Tandem Repeats

Functional Analyses of Protein Phosphatase 5

Roles of LRP130 and Tudor-SN/p100 in the Growth of Cancer Cells

Cell Migration

Genes Involved in Cancer Metastasis

Positive and Negative Regulation of Neural Apoptosis

Dysregulation of dNTP Pools in Cancer and Its Strategic Regulation

Roles of Tyrosine Kinases and their Substrates in Transformation and Migration of Tumor Cells

Involvement of the Eph Receptor Tyrosine Kinase and Ephrin Ligand in the Regulation of Cell-to-cell Adhesion

Cell Cycle Regulation of DNA Replication in Mammalian Cells and Its Implication in Carcinogenesis

Actinin-4 Enhances Cell Motility and Mediates Lymphatic Spread of Colorectal Cancer

Alternative Splice Variant of Actinin-4 in Small Cell Lung Cancer

Cancer-Stromal Interaction

Role of Nitric Oxide (NO) in Tumor Progression

Biochemical and Molecular Basis of Cellular Responses to Insufficient Blood Supply

Immunology

Anti-tumor Immunity of Immunocompetent Cells and Allogeneic Transplantation Immunotherapy

Immune Surveillance and Tumor Immunity at the Lipid Microdomains

Growth factors, cytokines and hormones

Isolation of Membrane and Secreted Proteins from Hematopoiesis-Supporting Stromal Cells

Direct Hepatic Fate Specification from Embryonic Stem Cells

Pathogenesis of Cancer Cachexia

Diagnosis and prognostic factors

Clinicopathological Studies

A Peptidomic Approach to Identify Secretory Peptides

Identification of Proteomic Signatures That Predict the Biological Behavior of Cancer Cells

Development of Multi-dimensional Liquid Chromatography for Plasma Biomarker Discovery

Gene Expression Analysis of AML

Gene Expression Analysis of Neuroblastoma

Clinicopathogical Studies on Various Cancers

Noninvasive Diagnostic Test for Colorectal Cancer

Development of innovative Diagnostic and Therapeutic Methods for Squamous Cell Carcinoma in situ in Head and Neck Mucosal Sites

Chemotherapy and radiation therapy

Molecular Correlative Study and Clinical Pharmacology

JCOG Data Center

Evaluation of Cancer Phenotypes on the Treatment for Cancer

Drug Delivery Systems (DDS) in Cancer Chemotherapy

Gene therapy

New Therapeutic Strategies for Cancer Therapy

Basic Studies on Gene Therapy

Antisense Oligos against HST-1/FGF-4 Suppresse Tumorigenicity of Human Germ Cell Tumors

Atelocollagen-mediated Effective Delivery of Synthetic Small Interfering RNAs in Mammalian Cells and Animals

IFN-a Gene Therapy against Pancreatic Cancer

Combination of Immune Gene and Cell Therapy

Development of a Fiber-modified Adenovirus Vector Library

Epidemiology

Cancer Registries and Surveillance

Epidemiological Studies

Population-based Prospective Study (the JPHC Study)

Gastric Cancer Prevention Trials (Hiraka Study)

Epidemiological Study on Japanese Brazilians (Sao Paulo - Japan Cancer Study)

Epidemiological Study on Endocrine Disrupting Chemicals

Other Epidemiological Studies

Human genome

Genes Involved in the Susceptibility to Lung and Gastric Cancers

Global Amplification of Genomic DNA and mRNA

Molecular Basis of Cancer Susceptibility

VR Technology and Transcription Factor Database (TFDB)

Other Research Projects

Investigation of the Genetic Basis of Cancer Susceptibility

Cancer information and biometry

WHO Collaborating Centre for Reference on Smoking and Health

Genetic and epigenetic alterations

Epigenetic Alteration during Multistage Carcinogenesis

Chromosome 9p21 Deletions in Human Lung Cancer

Genetic Susceptibility in Pediatric Leukemia

Other Studies Relevant to Molecular Carcinogenesis

DNA Methylation and Cancer

The Comprehensive Isolation of CpG Islands Methylated in Human Lung Cancer

Functional Relationship between Gene Silencing and DNA Methylation

The Improvement of the Bisulfite Modification Reaction

Psycho-Oncology

Inactivation of a Tumor Suppressor Gene, TSLC1, in Human Cancers

Depression in Cancer Patients

Other Psychological Distress in Cancer Patients

Refractory Symptoms in Advanced Cancer