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List of Papers Published in 2004

1. Pathology Division

1. Etoh T, Kanai Y, Ushijima S, Nakagawa T, Nakanishi Y, Sasako M, Kitano S, Hirohashi S. Increased DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancers. Am J Pathol, 164:689-699, 2004

2. Kanai Y, Saito Y, Ushijima S, Hirohashi S. Alterations in gene expression associated with the overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, during human hepatocarcinogenesis. J Cancer Res Clin Oncol, 130:636-644, 2004

3. Nam J-S, Ino Y, Kanai Y, Sakamoto M, Hirohashi S. 5-aza-2'-deoxycytidine restores the E-cadherin system in E-cadherin-silenced cancer cells and reduces cancer metastasis. Clin Exp Metastasis, 21:49- 56, 2004

4. Nakanishi Y, Akimoto S, Sato Y, Kanai Y, Sakamoto M, Hirohashi S. Prognostic significance of dysadherin expression in tongue cancer: immunohistochemical analysis of 91 cases. Appl Immunohistochem Mol Morphol, 12:323-328, 2004

5. Shimada Y, Yamasaki S, Hashimoto Y, Ito T, Kawamura J, Soma T, Ino Y, Nakanishi Y, Sakamoto M, Hirohashi S, Imamura M. Clinical significance of dysadherin expression in gastric cancer patients. Clin Cancer Res, 10:2818-2823, 2004

6. Shimada Y, Hashimoto Y, Kan T, Kawamura J, Okumura T, Soma T, Kondo K, Teratani N, Watanabe G, Ino Y, Sakamoto M, Hirohashi S, Imamura M. Prognostic significance of dysadherin expression in esophageal squamous cell carcinoma. Oncology, 67:73-80, 2004

7. Shimamura T, Yasuda J, Ino Y, Gotoh M, Tsuchiya A, Nakajima A, Sakamoto M, Kanai Y, Hirohashi S. Dysadherin expression facilitates cell motility and metastatic potential of human pancreatic cancer cells. Cancer Res, 64:6989-6995, 2004

8. Shibata T, Kokubu A, Sekine S, Kanai Y, Hirohashi S. Cytoplasmic p120ctn regulates the invasive phenotypes of E-cadherin-deficient breast cancer. Am J Pathol, 164:2269-2278, 2004

9. Akimoto S, Nakanishi Y, Sakamoto M, Kanai Y, Hirohashi S. Laminin 5 b3 and g2 chains are frequently coexpressed in cancer cells. Pathol Int, 54:688-692, 2004

10. Nakayama M, Sato Y, Okamoto M, Hirohashi S. Increased expression of laminin-5 and its prognostic significance in hypopharyngeal cancer. Laryngoscope, 114:1259-1263, 2004

11. Chuma M, Saeki N, Yamamoto Y, Ohta T, Asaka M, Hirohashi S, Sakamoto M. Expression profiling in hepatocellular carcinoma with intrahepatic metastasis: identification of high-mobility group I(Y) protein as a molecular marker of hepatocellular carcinoma metastasis. Keio J Med, 53:90-97, 2004

12. Chuma M, Sakamoto M, Yasuda J, Fujii G, Nakanishi K, Tsuchiya A, Ohta T, Asaka M, Hirohashi S. Overexpression of cortactin is involved in motility and metastasis of hepatocellular carcinoma. J Hepatol, 41:629-636, 2004

13. Loukopoulos P, Kanetaka K, Takamura M, Shibata T, Sakamoto M, Hirohashi S. Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activity. Pancreas, 29:193-203, 2004

14. Sekine S, Shimoda T, Nimura S, Nakanishi Y, Akasu T, Katai H, Gotoda T, Shibata T, Sakamoto M, Hirohashi S. High-grade dysplasia associated with fundic gland polyposis in a familial adenomatous polyposis patient, with special reference to APC mutation profiles. Mod Pathol, 17:1421-1426, 2004

15. Sekine S, Takata T, Shibata T, Mori M, Morishita Y, Noguchi M, Uchida T, Kanai Y, Hirohashi S. Expression of enamel proteins and LEF1 in adamantinomatous craniopharyngioma: evidence for its odontogenic epithelial differentiation. Histopathology, 45:573-579, 2004

16. Oshiro Y, Kusumoto M, Matsuno Y, Asamura H, Tsuchiya R, Terasaki H, Takei H, Maeshima A, Murayama S, Moriyama N. CT findings of surgically resected large cell neuroendocrine carcinoma of the lung in 38 patients. AJR, 182:87-91, 2004

17. Sakurai H, Hasegawa T, Watanabe S, Suzuki K, Asamura H, Tsuchiya R. Inflammatory myofibroblastic tumor of the lung. Eur J Cardiothorac Surg, 25:155-159, 2004

18. Nakagawa T, Kanai Y, Fujimoto H, Kitamura H, Furukawa H, Maeda S, Oyama T, Takesaki T, Hasegawa T. Malignant mixed epithelial and stromal tumours of the kidney: a report of the first two cases with a fatal clinical outcome. Histopathology, 44:302-304, 2004

19. Sakurai H, Maeshima A, Watanabe S, Suzuki K, Tsuchiya R, Maeshima AM, Matsuno Y, Asamura H. Grade of stromal invasion in small adenocarcinoma of the lung: histopathological minimal invasion and prognosis. Am J Surg Pathol, 28:198-206, 2004

20. Tateishi U, Hasegawa T, Beppu Y, Kawai A, Satake M, Moriyama N. Prognostic significance of MRI findings in patients with myxoid-round cell liposarcoma. AJR, 182:725-731, 2004

21. Tateishi U, Hasegawa T, Beppu Y, Satake M, Moriyama N. Synovial sarcoma of the soft tissues: prognostic significance of imaging features. J Comput Assist Tomogr, 28:140-148, 2004

22. Onishi Y, Matsuno Y, Tateishi U, Maeshima AM, Kusumoto M, Terauchi T, Kusumoto S, Sekiguchi N, Tanimoto K, Watanabe T, Kobayashi Y, Tobinai K. Two entities of precursor T-cell lymphoblastic leukemia/lymphoma based on radiologic and immunophenotypic findings. Int J Hematol, 80:43-51, 2004

23. Sonoda I, Imoto I, Inoue J, Shibata T, Shimada Y, Chin K, Imamura M, Amagasa T, Gray JW, Hirohashi S, Inazawa J. Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma. Cancer Res, 64:3741-3747, 2004

24. Yachida S, Nakanishi Y, Shimoda T, Nimura S, Igaki H, Tachimori Y, Kato H. Adenosquamous carcinoma of the esophagus: clinicopathologic study of 18 cases. Oncology, 66:218-225, 2004

25. Yamaguchi U, Hasegawa T, Masuda T, Sekine S, Kawai A, Chuman H, Shimoda T. Differential diagnosis of gastrointestinal stromal tumor and other spindle cell tumors in the gastrointestinal tract based on immunohistochemical analysis. Virchows Arch, 445:142-150, 2004

26. Okada K, Hasegawa T, Tateishi U, Itoi E. Second primary osteosarcoma with rosette-like structure in a patient with retinoblastoma. Virchows Arch, 445:421-424, 2004

27. Sakurai S, Hasegawa T, Sakuma Y, Takazawa Y, Motegi A, Nakajima T, Saito K, Fukayama M, Shimoda T. Myxoid epithelioid gastrointestinal stromal tumor (GIST) with mast cell infiltrations: a subtype of GIST with mutations of platelet-derived growth factor receptor alpha gene. Hum Pathol, 35:1223- 1230, 2004

28. Takayasu K, Muramatsu Y, Mizuguchi Y, Moriyama N, Ojima H. Imaging of early hepatocellular carcinoma and adenomatous hyperplasia (dysplastic nodules) with dynamic CT and a combination of CT and angiography: experience with resected liver specimens. Intervirology, 47:199-208, 2004

29. Shimizu C, Hasegawa T, Tani Y, Takahashi F, Takeuchi M, Watanabe T, Ando M, Katsumata N, Fujiwara Y. Expression of insulin-like growth factor 1 receptor in primary breast cancer: immunohistochemical analysis. Hum Pathol, 35:1537-1542, 2004

30. Maeda T, Tateishi U, Nakagawa T, Ojima H, Kanai Y, Fujimoto H. Collecting duct carcinoma of the kidney presenting uncommon findings. Eur J Radiol Extra, 49:25-29, 2004

2. Biochemistry Division

31. Ochiai M, Sugimura T, Nagao M. Modification of the 32P-postlabeling method to ditect a single adduct species as a single spot. Methods In Molecular Biology, 291:13-19, 2004

32. Fujiwara K, Ochiai M, Ohta T, Ohki M, Aburatani H, Nagao M, Sugimura T, Nakagama, H. Global gene expression analysis of rat colon cancers induced by a food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Carcinogenesis, 25:1495-1505, 2004

33. Uchida S, Ohtsubo M, Shimura M, Hirata M, Nakagama H, Matsunaga T, Yoshida M, Ishizaka Y, Yamashita K. Nuclear export signal in CDC25B. Biochem Biophys Res Commun, 316:226-232, 2004

34. Uchida S, Kuma A, Ohtsubo M, Shimura M, Hirata M, Nakagama H, Matsunaga T, Ishizaka Y, Yamashita K. Binding of 14-3-3b but not 14-3-3a controls the cytoplasmic localization of CDC25B: binding site preferences of 14-3-3 subtypes and the subcellular localization of CDC25B. J Cell Sci, 117:3011-3020, 2004

35. Tsuchiya N, Fukuda H, Nakashima K, Nagao M, Sugimura T, Nakagama H. LRP130, a single-stranded DNA/RNA-binding protein, localizes at the outer nuclear and endoplasmic reticulum membrane, and interacts with mRNA in vivo. Biochem Biophys Res Commun, 317:736-743, 2004

36. Watanabe F, Fukazawa H, Masutani M, Suzuki H, Teraoka H, Mizutani S, Uehara Y. Poly(ADP-ribose) polymerase-1 inhibits ATM kinase activity in DNA damage response. Biochem Biophys Res Commun, 319:596-602, 2004

37. Lan L, Nakajima S, Oohata Y, Takao M, Okano S, Masutani M, Wilson SH, Yasui A. In situ analysis of repair processes for oxidative DNA damage in mammalian cells. PNAS, 101:13738-13743, 2004

38. Shibata A, Masutani M, Kamada N, Masumura K, Nakagama H, Kobayashi S, Teraoka H, Suzuki H, Nohmi T. Efficient method for mapping and characterizing structures of deletion mutations in gpt delta mice using Southern blot analysis with oligo DNA probes. Environ Mol Mutagen, 43:204-207, 2004

39. Masutani M, Ikejima M, Mariotto S, Nozaki T, Kurata S, Natori S, Esumi H, Sugimura T. Developmental changes of poly(ADP-ribose) polymerase expression in Sarcophaga peregrina. Proc Jpn Acad Ser B, 80:336-341, 2004

40. Ogino H, Gunji A, Kamada N, Nakagama H, Sugimura T, Masutani M. Stability of centrosome numbers in poly(ADP-ribose) polymerase-1- and poly(ADP-ribose) glycohydrolase-deficient mouse ES cells. Proc Jpn Acad Ser B, 80:290-294, 2004

41. Masutani M, Nozaki T, Sasaki H, Yamada T, Kohno T, Shimizu K, Gotoh M, Shiraishi M, Yokota J, Hirohashi S, Nakagama H, Sugimura T. Poly (ADP-ribose) polymerase-1 gene in human tumor cell lines: its expression and structural alteration. Proc Jpn Acad Ser B, 80:114-118, 2004

3. Chemotherapy Division

42. Honda K, Yamada T, Seike M, Hayashida Y, Idogawa M, Kondo T, Ino Y, Hirohashi S. Alternative splice variant of actinin-4 in small cell lung cancer. Oncogene, 1-6, 2004

43. Liu QY, Lei X-a, LeBlanc J, Sodja C, Ly D, Charlebois C, Walker RP, Yamada T, Hirohashi S, Sikorska M. Regulation of DNase Y activity by actinin-a4 during apoptosis. Cell Death Differ, 1-10, 2004

44. Iigo M, Shimamura M, Matsuda E, Fujita K, Nomoto H, Satoh J, Kojima S, Alexander DB, Moore MA, Tsuda H. Orally administered bovine lactoferrin induces caspase-1 and interleukin-18 in the mouse intestinal mucosa: a possible explanation for inhibition of carcinogenesis and metastasis. Cytokine, 25:36-44, 2004

45. Shimamura M, Yamamoto Y, Ashino H, Oikawa T, Hazato T, Tsuda H, Iigo M. Bovine lactoferrin inhibits tumor-induced angiogenesis. Int J Cancer, 111:111-116, 2004

46. Fujita K, Matsuda E, Sekine K, Iigo M, Tsuda H. Lactoferrin enhances Fas expression and apoptosis in the colon mucosa of azoxymethane-treated rats. Carcinogenesis, 25:1961-1966, 2004

47. Fujita K, Matsuda E, Sekine K, Iigo M, Tsuda H. Lactoferrin modifies apoptosis-related gene expression in the colon of the azoxymethane-treated rat. Cancer Lett, 213:21-29, 2004

48. Takahashi T, Takasuka N, Iigo M, Baba M, Nishino H, Tsuda H, Okuyama T. Isoliquiritigenin, a flavonoid from licorice, reduces prostaglandin E2 and nitric oxide, causes apoptosis, and suppresses aberrant crypt foci development. Cancer Sci, 95:448-453, 2004

49. Nomoto H, Iigo M, Hamada H, Kojima S, Tsuda H. Chemoprevention of colorectal cancer by grape seed proanthocyanidin is accompanied by a decrease in proliferation and increase in apoptosis. Nutr Cancer, 49:81-88, 2004

50. Tsuda H, Ohshima Y, Nomoto H, Fujita K, Matsuda E, Iigo M, Takasuka N, Moore MA. Cancer prevention by natural compounds. Drug Metab Pharmacokin, 19:245-263, 2004

51. Park CB, Fukamachi K, Takasuka N, Han BS, Kim CK, Hamaguchi T, Fujita K, Ueda S, Tsuda H. Rapid induction of skin and mammary tumors in human c-Ha-ras proto-oncogene transgenic rats by treatment with 7,12-dimethylbenz[a]anthracene followed by 12-O-tetradecanoylphorbol 13-acetate. Cancer Sci, 95:205-210, 2004

52. Hamaguchi T, Matsuoka Y, Kawaguchi H, Fukamachi K, Takasuka N, Ueda S, Shimizu K, Ohki M, Kusunoki M, Sakakura T, Yoshida H, Tsuda H. Terminal endbuds and acini as the respective major targets for chemical and sporadic carcinogenesis in the mammary glands of human c-Ha-ras protooncogene transgenic rats. Breast Cancer Res Treat, 83:43-56, 2004

53. Naito A, Suzuki A, Ueda S, Nomoto H, Toriyama-Baba H, Asamoto M, Tsuda H. Preferential mammary carcinogenic effects of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in human c-Ha-ras proto-oncogene transgenic rats. Cancer Sci, 95:399-403, 2004

54. Fukamachi K, Han BS, Kim CK, Takasuka N, Matsuoka Y, Matsuda E, Yamasaki T, Tsuda H. Possible enhancing effects of atrazine and nonylphenol on 7,12-dimethylbenz[a]anthracene-induced mammary tumor development in human c-Ha-ras proto-oncogene transgenic rats. Cancer Sci, 95:404-410, 2004

4. Biology Division

55. Yokota J, Kohno T. Molecular footprints of human lung cancer progression. Cancer Sci, 95:197-204, 2004

56. Tani M, Ito J, Nishioka M, Kohno T, Tachibana K, Shiraishi M, Takenoshita S, Yokota J. Correlation between histone acetylation and expression of the MYO18B gene in human lung cancer cells. Genes Chromosomes Cancer, 40:146-151, 2004

57. Yanaihara N, Nishioka M, Kohno T, Otsuka A, Okamoto A, Ochiai K, Tanaka T, Yokota J. Reduced expression of MYO18B, a candidate tumor suppressor gene on chromosome arm 22q, in ovarian cancer. Int J Cancer, 112:150-154, 2004

58. Kobayashi K, Nishioka M, Kohno T, Nakamoto M, Maeshima A, Aoyagi K, Sasaki H, Takenoshita S, Sugimura H, Yokota J. Identification of genes whose expression is upregulated in lung adenocarcinoma cells in comparison with type II alveolar cells and bronchiolar epithelial cells in vivo. Oncogene, 23:3089-3096, 2004

59. Yamane A, Kohno T, Ito K, Sunaga N, Aoki K, Yoshimura K, Murakami H, Nojima Y, Yokota J. Differential ability of polymorphic OGG1 proteins to suppress mutagenesis induced by 8-hydroxyguanine in human cell in vivo. Carcinogenesis, 25:1689-1694, 2004

60. Kim S-R, Matsui K, Yamada M, Kohno T, Kasai H, Yokota J, Nohmi T. Suppression of chemically induced and spontaneously occurring oxidative mutagenesis by three alleles of human OGG1 gene encoding 8-hydroxyguanine DNA glycosylase. Mutat Res, 554:365-374, 2004

61. Gong Z, Teixeira C, Xing JZ, Yokota J, Kohno T, Gabos S, Le XC, Li X-F. Electronic microarray technique for detection of nine base substitutions including single-nucleotide polymorphisms in the human OGG1 gene. Clin Chem, 50:1441-1444, 2004

62. Yabuta T, Shinmura K, Yamane A, Yamaguchi S, Takenoshita S, Yokota J. Effect of exogenous MSH6 and POLD1 expression on the mutation rate of the HPRT locus in a human colon cancer cell line with mutator phenotype, DLD-1. Int J Oncol, 24:697-702, 2004

63. Fujieda M, Yamazaki H, Saito T, Kiyotani K, Gyamfi MA, Sakurai M, Dosaka-Akita, H, Sawamura Y, Yokota J, Kunitoh H, Kamataki, T. Evaluation of CYP2A6 genetic polymorphisms as determinants of smoking behavior and tobacco-related lung cancer risk in male Japanese smokers. Carcinogenesis, 25:2451-2458, 2004

64. Sunayama J, Ando Y, Itoh N, Tomiyama A, Sakurada K, Sugiyama A, Kang D, Tashiro F, Gotoh Y, Kuchino Y, Kitanaka C. Physical and functional interaction between BH3-only protein Hrk and mitochondrial pore-forming protein p32. Cell Death Differ, 11:771-781, 2004

5. Pharmacology Division

65. Shimizu A, Sasaki H, Aoyagi K, Yoshida M, Kato K, Heike Y, Ikarashi Y, Shirakawa K, Takaue Y, Miyajima A, Terada M, Nagai H, Wakasugi H. The mouse natural killer T cell-associated antigen recognized by U5A2-13 monoclonal antibody is intercellular adhesion molecule-1. Immunol Lett, 92:227-235, 2004

66. Ikarashi Y, Heike Y, Shimizu A, Imataki O, Kanai S, Yoshida M, Iiduka A, Morikawa T, Takaue Y, Wakasugi H. Role of natural killer T cells in anti-tumor immune response. In: Toyoshima K, Barrett JC, Klein E, Hashimoto Y, Wakasugi H (eds), Cancer Immunotherapy. Extended Abstracts for the 34th International Symposium of the Princess Takamatsu Cancer Research Fund. Japan, Princess Takamatsu Cancer Research Fund, pp 57-63, 2004

67. Terme M, Tomasello E, Maruyama K, Crepineau F, Chaput N, Flament C, Marolleau JP, Angevin E, Wagner EF, Salomon B, Lemonnier FA, Wakasugi H, Colonna M, Vivier E, Zitvogel L. IL-4 confers NK stimulatory capacity to murine dendritic cells: A signaling pathway involving KARAP/DAP12-triggering receptor expressed on myeloid cell 2 molecules. J Immunol, 172:5957-5966, 2004

68. Borg C, Terme M, Taieb J, Menard C, Flament C, Robert C, Maruyama K, Wakasugi H, Angevin E, Thielemans K, Le Cesne A, Chung-Scott V, Lazar V, Tchou I, Crepineau F, Lemoine F, Bernard J, Fletcher JA, Turhan A, Blay JY, Spatz A, Emile JF, Heinrich MC, Mecheri S, Tursz T, Zitvogel L. Novel mode of action of c-kit tyrosine kinase inhibitors leading to NK cell-dependent antitumor effects. J Clin Invest, 114:379-388, 2004

69. Borg C, Jalil A, Laderach D, Maruyama K, Wakasugi H, Charrier S, Ryffel B, Cambi A, Figdor C, Vainchenker W, Galy A, Caignard A, Zitvogel L. NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs. Blood, 104:3267-3275, 2004

70. Heike Y, Kami M, Mori S, Tanosaki R, Miyakoshi S, Taniguchi S, Wakasugi H, Takaue Y. Allogeneic immune-mediated anti-cancer effect with reduced-intensity stem cell transplantation. In: Toyoshima K, Barrett JC, Klein E, Hashimoto Y, Wakasugi H (eds), Cancer Immunotherapy. Extended Abstracts for the 34th International Symposium of the Princess Takamatsu Cancer Research Fund. Japan, Princess Takamatsu Cancer Research Fund, pp 99-104, 2004

71. Matsuda K. Phosphoholine-containing glycoglycerolipids of Mycoplasma fermentans as a pathogen of rheumatoid arthritis: possible role of Mycoplasma fermentans GGPLs in the pathogenesis of neuroen docrine-immune abnormalities. Recent Res Dev Neurosci, 1:15-23, 2004

72. Koizumi F, Kanzawa F, Ueda Y, Koh Y, Tsukiyama S, Taguchi F, Tamura T, Saijo N, Nishio K. Synergistic interaction between the EGFR tyrosine kinase inhibitor gefitinib ("Iressa") and the DNA topoisomerase I inhibitor CPT-11 (Irinotecan) in human colorectal cancer cells. Int J Cancer, 108:464-472, 2004

73. Park JK, Lee SH, Kang JH, Nishio K, Saijo N, Kuh HJ. Synergistic interaction between gefitinib (Iressa, ZD1839) and paclitaxel against human gastric carcinoma cells. Anticancer Drugs, 15:809-818, 2004

74. Taguchi F, Koh Y, Koizumi F, Tamura T, Saijo N, Nishio K. Anticancer effects of ZD6474, a VEGF receptor tyrosine kinase inhibitor, in gefitinib ("Iressa")-sensitive and resistant xenograft models. Cancer Sci, 95:984-989, 2004

75. Arao T, Fukumoto H, Takeda M, Tamura T, Saijo N, Nishio K. Small in-frame deletion in the epidermal growth factor receptor as a target for ZD6474. Cancer Res, 64:9101-9104, 2004

76. Taguchi F, Kusaba H, Asai A, Iwamoto Y, Yano K, Nakano H, Mizukami T, Saijo N, Kato H, Nishio K. hnRNP L enhances sensitivity of the cells to KW-2189. Int J Cancer, 108:679-685, 2004

77. Nishio K, Korfee S, Eberhardt W, Saijo N, Tamura T. Translational research for lung cancer - An update. In: Jassem J (ed), 9th Central European Lung Cancer Conference. Italy, Medimond S.r.l., pp 45-47, 2004

6. Cancer Medicine and Biophysics Division

78. Yoon K-A, Nakamura Y, Arakawa H. Idenrification of ALDH4 as a p53-inducible gene and its protective role in cellular stresses. J Hum Genet, 49:134-140, 2004

79. Anazawa Y, Arakawa H, Nakagawa H, Nakamura Y. Identification of STAG1 as a key mediator of a p53-dependent apoptotic pathway. Oncogene, 23:7621-7627, 2004

80. Arakawa H. Netrin-1 and its receptors in tumorigenesis. Nat Rev Cancer, 4:978-987, 2004

81. Graff P, Seim J, Amellem O, Arakawa H, Nakamura Y, Andersson KK, Stokke T, Pettersen EO. Counteraction of pRb-dependent protection after extreme hypoxia by elevated ribonucleotide reductase. Cell Prolif, 37:367-383, 2004

82. Yoshida K, Monden M, Nakamura Y, Arakawa H. Adenovirus-mediated p53AIP1 gene transfer as a new strategy for treatment of p53-resistant tumors. Cancer Sci, 95:91-97, 2004

83. Oda Y, Muramatsu T, Yumoto F, Ito M, Tanokura M. Backbone 1H, 13C and 15N resonance assignment of the N-terminal domain of human eRF1. J Biomol NMR, 30:109-110, 2004

84. Muramatsu T, Oda Y, Yumoto F, Ito M, Tanokura M. Analysis of dynamic structure of eukaryotic release factor 1 (eRF1). Bioimages, 12:37, 2004

85. Sasaki H, Nakagawa A, Muramatsu T, Suganuma M, Sawano Y, Kojima M, Kubota K, Takahashi K, Tanokura M. The three-dimensional structure of aspergilloglutamic peptidase from Aspergillus niger. Proc Jpn Acad Ser B, 80:435-438, 2004

86. Kim Y-T, Kurita R, Kojima M, Nishii W, Tanokura M, Muramatsu T, Ito H, Takahashi K. Identification of arginine residues important for the activity of Escherichia coli signal peptidase I. Biol Chem, 385:381-388, 2004

7. Growth Factor Division

87. Tanaka M, Ohashi R, Nakamura R, Shinmura K, Kamo T, Sakai R, Sugimura H. Tiam1 mediates neurite outgrowth induced by ephrin-B1 and EphA2. EMBO J, 23:1075-1088, 2004

88. Kataoka H, Igarashi H, Kanamori M, Ihara M, Wang J-D, Wang Y-J, Li Z-Y, Shimamura T, Kobayashi T, Maruyama K, Nakamura T, Arai H, Kajimura M, Hanai H, Tanaka M, Sugimura H. Correlation of EPHA2 overexpression with high microvessel count in human primary colorectal cancer. Cancer Sci, 95:136-141, 2004

89. Ueki T, Tanaka M, Yamashita K, Mikawa S, Qiu Z, Maragakis NJ, Hevner RF, Miura N, Sugimura H, Sato K. A novel secretory factor, Neurogenesin-1, provides neurogenic environmental cues for neural stem cells in the adult hippocampus. J Neurosci, 23:11732-11740, 2003

90. Azuma K, Horie K, Inoue S, Ouchi Y, Sakai R. Analysis of estrogen receptor a signaling complex at the plasma membrane. FEBS Lett, 577:339-344, 2004

8. Molecular Oncology Division

91. Yokoyama A, Wang Z, Wysocka J, Sanyal M, Aufiero DJ, Kitabayashi I, Herr W, Cleary ML. Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression. Mol Cell Biol, 24:5639-5649, 2004

92. Shimada H, Shimizu K, Mimaki S, Sakiyama T, Mori T, Shimasaki N, Yokota J, Nakachi K, Ohta T, Ohki M. First case of aplastic anemia in a Japanese child with a homozygous missense mutation in the NBS1 gene (I171V) associated with genomic instability. Hum Genet, 115:372-376, 2004

93. Takagi M, Tsuchida R, Oguchi K, Shigeta T, Nakada S, Shimizu K, Ohki M, Delia D, Chessa L, Taya Y, Nakanishi M, Tsunematsu Y, Bessho F, Isoyama K, Hayashi Y, Kudo K, Okamura J, Mizutani S. Identification and characterization of polymorphic variations of the ataxia telangiectasia mutated (ATM) gene in childhood Hodgkin disease. Blood, 103:283-290, 2004

94. Shimada H, Mori T, Shimasaki N, Shimizu K, Takahashi T, Kosaki K. Somatic PTPN11 mutation with a heterogeneous clonal origin in children with juvenile myelomonocytic leukemia. Leukemia, 18:1142-1144, 2004

9. Virology Division

95. Gewin L, Myers H, Kiyono T, Galloway DA. Identification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6/E6-AP complex. Genes Dev, 18:2269-2282, 2004

96. Oikawa K, Ohbayashi T, Kiyono T, Nishi H, Isaka K, Umezawa A, Kuroda M, Mukai K. Expression of a novel human gene, human wings apart-like (hWAPL), is associated with cervical carcinogenesis and tumor progression. Cancer Res, 64:3545-3549, 2004

97. Takeda Y, Mori T, Imabayashi H, Kiyono T, Gojo S, Miyoshi S, Hida N, Ita M, Segawa K, Ogawa S, Sakamoto M, Nakamura S, Umezawa A. Can the life span of human marrow stromal cells be prolonged by bmi-1, E6, E7, and/or telomerase without affecting cardiomyogenic differentiation? J Gene Med, 6:833-845, 2004

98. Kawabe A, Shimada Y, Soma T, Maeda M, Itami A, Kaganoi J, Kiyono T, Imamura M. Production of prostaglandinE2 via bile acid is enhanced by trypsin and acid in normal human esophageal epithelial cells. Life Sci, 75: 21-34, 2004

99. Sawada M, Nakashima S, Kiyono T, Naganawa T, Yamada J, Nakagawa M, Hara S, Shinoda J, Iwama T, Sakai N. Molecular mechanisms of TNF-a-induced ceramide formation in human glioma cells:p53- mediated oxidant stress-dependent and -independent pathways. Cell Death Differ, 11:997-1008, 2004

100. Hara S, Nakashima S, Kiyono T, Sawada M, Yoshimura S, Iwama T, Banno Y, Shinoda J, Sakai N. p53-Independent ceramide formation in human glioma cells during g-radiation-induced apoptosis. Cell Death Differ, 11:853-861, 2004

101. Hara S, Nakashima S, Kiyono T, Sawada M, Yoshimura S, Iwama T, Sakai N. Ceramide triggers caspase activation during g-radiation-induced apoptosis of human glioma cells lacking functional p53. Oncol Rep, 12:119-123, 2004

102. Sugimoto N, Tatsumi Y, Tsurumi T, Matsukage A, Kiyono T, Nishitani H, Fujita M. Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding. J Biol Chem, 19:19691-19697, 2004

103. Kudoh A, Daikoku T, Sugaya Y, Isomura H, Fujita M, Kiyono T, Nishiyama Y, Tsurumi T. Inhibition of S-phase cyclin-dependent kinase activity blocks expression of Epstein-Barr virus immediate-early and early genes, preventing viral lytic replication. J Virol, 78:104-115, 2004

104. Daikoku T, Kudoh A, Fujita M, Sugaya Y, Isomura H, Tsurumi T. In vivo dynamics of EBNA1-oriP interaction during latent and lytic replication of Epstein-Barr virus. J Biol Chem, 279:54817-54825, 2004

105. Li N, Nakamura K, Jiang Y, Tsurui H, MatsuokaS, Abe M, Ohtsuji M, Nishimura H, Kato K, Kawai T, Atsumi T, Koike T, Shirai T, Ueno H, Hirose S. Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus. Hum Mol Genet, 13:171-179, 2004

10. Genetics Division

106. Mori K, Aoyagi K, Ueda T, Danjoh I, Tsubosa Y, Yanagihara K, Matsuno Y, Sasako M, Sakamoto H, Mafune K, Kaminishi M, Yoshida T, Terada M, Sasaki H. Highly specific marker genes for detecting minimal gastric cancer cells in cytology negative peritoneal washings. Biochem Biophys Res Commun, 313:931-937, 2004

107. Kuwahara Y, Tanabe C, Ikeuchi T, Aoyagi K, Nishigaki M, Sakamoto H, Hoshinaga K, Yoshida T, Sasaki H, Terada M. Alternative mechanisms of gene amplification in human cancers. Genes Chromosomes Cancer, 41:125-132, 2004

108. Ishida M, Tanaka S, Ohki M, Ohta T. Transcriptional co-activator activity of SYT is negatively regulated by BRM and Brg1. Genes Cells, 9:419-428, 2004

109. Tanaka Y, Tawaramoto-Sasanuma M, Kawaguchi S, Ohta T, Yoda K, Kurumizaka H, Yokoyama S. Expression and purification of recombinant human histones. Methods, 33:3-11, 2004

110. Aihara H, Nakagawa T, Yasui K, Ohta T, Hirose S, Dhomae N, Takio K, Kaneko M, Takeshima Y, Muramatsu M, Ito T. Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo. Genes Dev, 18:877-888, 2004

111. Garciadiego-Cazares D, Rosales C, Katoh M, Chimal-Monroy J. Coordination of chondrocyte differentiation and joint formation by a5b1 integrin in the developing appendicular skeleton. Development, 131:4735-4742, 2004

112. Katoh M, Katoh M. Identification and characterization of human CKTSF1B2 and CKTSF1B3 genes in silico. Oncol Rep, 12:423-427, 2004

113. Katoh M, Katoh M. Identification and characterization of human HES2, HES3, and HES5 genes in silico. Int J Oncol, 25:529-534, 2004

114. Katoh M, Katoh M. Identification and characterization of human HESL, rat Hesl and rainbow trout hesl genes in silico. Int J Mol Med, 14:747-751, 2004

115. Katoh Y, Katoh M. KIF27 is one of orthologs for Drosophila Costal-2. Int J Oncol, 25:1875-1880, 2004

116. Katoh Y, Katoh M. Characterization of KIF7 gene in silico. Int J Oncol, 25:1881-1886, 2004

117. Katoh M, Katoh M. Human FOX gene family (Review). Int J Oncol, 25:1495-1500, 2004

118. Katoh M, Katoh M. Identification and characterization of human FOXK1 gene in silico. Int J Mol Med, 14:127-132, 2004

119. Katoh M, Katoh M. Characterization of human FOXN4 gene in silico. Int J Mol Med, 14:949-953, 2004

120. Katoh M, Katoh M. Identification and characterization of human FOXN5 and rat Foxn5 genes in silico. Int J Oncol, 24:1339-1344, 2004

121. Katoh M, Katoh M. Germ-line mutation of Foxn5 gene in mouse lineage. Int J Mol Med, 14:463-467, 2004

122. Katoh M, Katoh M. Identification and characterization of human FOXN6, mouse Foxn6, and rat Foxn6 genes in silico. Int J Oncol, 25:219-223, 2004

123. Katoh M, Katoh M. Pharmacogenomics on gastric cancer. Cancer Biol Ther, 3:566-567, 2004

124. Katoh M, Katoh M. Evolutionary recombination hotspot around GSDML-GSDM locus is closely linked to oncogenomic recombination hotspot around PPP1R1B-ERBB2-GRB7 amplicon. Int J Oncol, 24:757-763, 2004

125. Katoh M, Katoh M. Identification and characterization of human DFNA5L, mouse Dfna5l, and rat Dfna5l genes in silico. Int J Oncol, 25:765-770, 2004

126. Katoh M, Katoh M. Identification and characterization of TMEM24 family genes in silico. Int J Oncol, 25:759-764, 2004

127. Katoh M, Katoh M. Identification and characterization of human TMEM25 and mouse Tmem25 genes in silico. Oncol Rep, 12:429-433, 2004

128. Katoh M, Katoh M. Identification and characterization of the human FMN1 gene in silico. Int J Mol Med, 14:121-126, 2004

129. Katoh M, Katoh M. Characterization of FMN2 gene at human chromosome 1q43. Int J Mol Med, 14:469-474, 2004

130. Katoh M, Katoh M. Identification and characterization of human FHDC1, mouse Fhdc1, and zebrafish fhdc1 gene in silico. Int J Mol Med, 13:929-934, 2004

131. Katoh M, Katoh M. Identification and characterization of human FHOD3 gene in silico. Int J Mol Med, 13:615-620, 2004

132. Katoh M, Katoh M. Identification and characterization of human DIAPH3 gene in silico. Int J Mol Med, 13:473-478, 2004

133. Katoh M, Katoh M. Characterization of human ARHGAP10 gene in silico. Int J Oncol, 25:1201-1206, 2004

134. Katoh M, Katoh M. Identification and characterization of human ARHGAP23 gene in silico. Int J Oncol, 25:535-540, 2004

135. Katoh M, Katoh M. Identification and characterization of ARHGAP24 and ARHGAP25 genes in silico. Int J Mol Med, 14:333-338, 2004

136. Katoh Y, Katoh M. Identification and characterization of ARHGAP27 gene in silico. Int J Mol Med, 14:943-947, 2004

137. Katoh M, Katoh M. Identification and characterization of human MPP7 gene and mouse Mpp7 gene in silico. Int J Mol Med, 13:333-338, 2004

138. Katoh M, Katoh M. Identification and characterization of Crumbs homolog 2 gene at human chromosome 9q33.3. Int J Oncol, 24:743-749, 2004

139. Katoh M, Katoh M. Identification and characterization of human LLGL4 gene and mouse Llgl4 gene in silico. Int J Oncol, 24:737-742, 2004

140. Katoh M, Katoh M. Identification and characterization of human GUKH2 gene in silico. Int J Oncol, 24:1033-1038, 2004

141. Katoh M, Katoh M. Identification and characterization of human FNBP1L gene in silico. Int J Mol Med, 13:157-162, 2004

142. Katoh M, Katoh M. Identification and characterization of PDZRN3 and PDZRN4 genes in silico. Int J Mol Med, 13:607-613, 2004

143. Katoh M, Katoh M. Identification and characterization of human PDZRN4L gene and mouse Pdzrn4l gene in silico. Int J Mol Med, 13:923-927, 2004

144. Katoh M, Katoh M. Identification and characterization of human FCHSD1 and FCHSD2 genes in silico. Int J Mol Med, 13:749-754, 2004

145. Katoh M, Katoh M. Identification and characterization of human FCHO2 and mouse Fcho2 genes in silico. Int J Mol Med, 14:327-331, 2004

146. Katoh M, Katoh M. Identification and characterization of ASXL3 gene in silico. Int J Oncol, 24:1617-1622, 2004

147. Katoh M, Katoh M. Identification and characterization of JMJD2 family genes in silico. Int J Oncol, 24:1623-1628, 2004

148. Katoh M, Katoh M. Characterization of RUSC1 and RUSC2 genes in silico. Oncol Rep, 12:933-938, 2004

149. Katoh M, Katoh M. Identification and characterization of human CXXC10 gene in silico. Int J Oncol, 25:1193-1199, 2004

150. Katoh M, Katoh M. Identification and characterization of FBXL19 gene in silico. Int J Mol Med, 14:1109-1114, 2004

151. Katoh Y, Katoh M. Identification and characterization of CDC50A, CDC50B and CDC50C genes in silico. Oncol Rep, 12:939-943, 2004

152. Katoh M, Katoh M. Identification and characterization of TMEM16E and TMEM16F genes in silico. Int J Oncol, 24:1345-1349, 2004

153. Katoh M, Katoh M. Characterization of human TMEM16G gene in silico. Int J Mol Med, 14:759-764, 2004

154. Katoh M, Katoh M. Identification and characterization of human TP53I5 and mouse Tp53i5 genes in silico. Int J Oncol, 25:225-230, 2004

155. Sato Y, Suganami H, Hamada C, Yoshimura I, Yoshida T, Yoshimura K. Designing a multistage, SNPbased, genome screen for common diseases. Hum Genet, 49:669-676, 2004

156. Miyakura Y, Sugano K, Akasu T, Yoshida T, Maekawa M, Saitoh S, Sasaki H, Nomizu T, Konishi F, Fujita S, Moriya Y, Nagai H. Extensive but hemiallelic methylation of the hMLH1 promoter region in early-onset sporadic colon cancers with microsatellite instability. Clin Gastroenterol Hepatol, 2:147-156, 2004

157. Sugano K, Yoshida T, Izumi H, Umezawa S, Ushiama M, Ichikawa A, Hidaka A, Murakami Y, Kodama T, Suzuki S, Kaneko A. Outpatient clinic for genetic counseling and gene testing of retinoblastoma. Int J Clin Oncol, 9:25-30, 2004

158. Fukushima-Uesaka H, Sai K, Maekawa K, Koyano S, Kaniwa N, Ozawa S, Kawamoto M, Kamatani N, Komamura K, Kamakura S, Kitakaze M, Tomoike H, Ueno K, Minami H, Ohtsu A, Shirao K, Yoshida T, Saijo N, Saito Y, Sawada J. Genetic variations of the AHR gene encoding aryl hydrocarbon receptor in a Japanese population. Drug Metab Pharmacokin, 19:320-326, 2004

159. Sai K, Saeki M, Saito Y, Ozawa S, Katori N, Jinno H, Hasegawa R, Kaniwa N, Sawada J, Komamura K, Ueno K, Kamakura S, Kitakaze M, Kitamura Y, Kamatani N, Minami H, Ohtsu A, Shirao K, Yoshida T, Saijo N. UGT1A1 haplotypes associated with reduced glucuronidation and increased serum bilirubin in irinotecan-administered Japanese patients with cancer. Clin Pharmacol Ther, 75:501-515, 2004

160. Goto J, Tezuka T, Nakazawa T, Tsukamoto N, Nakamura T, Ajima R, Yokoyama K, Ohta T, Ohki M, Yamamoto T. Altered gene expression in the adult brain of fyn-deficient mice. Cell Mol Neurobiol, 24:149-159, 2004

161. Terasaka S, Aita Y, Inoue A, Hayashi S, Nishigaki M, Aoyagi K, Sasaki H, Wada-Kiyama Y, Sakuma Y, Akaba S, Tanaka J, Sone H, Yonemoto J, Tanji M, Kiyama R. Using a customized DNA microarray for expression profiling of the estrogen-responsive genes to evaluate estrogen activity among natural estrogens and industrial chemicals. Environ Health Perspect, 112:773-781, 2004

162. Kobayashi A, Ohta T, Yamamoto M. Unique function of the Nrf2-Keap1 pathway in the inducible expression of antioxidant and detoxifying enzymes. Methods Enzymol, 378:273-286, 2004

163. Yamada S, Kohu K, Ishii T, Ishidoya S, Hiramatsu M, Kanto S, Fukuzaki A, Adachi Y, Endoh M, Moriya T, Sasaki H, Satake M, Arai Y. Gene expression profiling identifies a set of transcripts that are up-regulated in human testicular seminoma. DNA Res, 11:335-344, 2004

164. Narikiyo M, Tanabe C, Yamada Y, Igaki H, Tachimori Y, Kato H, Muto M, Montesano R, Sakamoto H, Nakajima Y, Sasaki H. Frequent and preferential infection of Treponema denticola, Streptococcus mitis, and Streptococcus anginosus in esophageal cancers. Cancer Sci, 95:569-574, 2004

165. Morita E, Narikiyo M, Nishimura E, Yano A, Tanabe C, Sasaki H, Hamada N. Molecular analysis of age-related changes of Streptococcus anginosus group and Streptococcus mitis in saliva. Oral Microbiol Immunol, 19:386-389, 2004

11. Radiobiology Division

166. Ohtani S, Kagawa S, Tango Y, Umeoka T, Tokunaga N, Tsunemitsu Y, Roth JA, Taya Y, Tanaka N, Fujiwara T. Quantitative analysis of p53-targeted gene expression and visualization of p53 transcriptional activity following intratumoral administration of adenoviral p53 in vivo. Mol Cancer Ther, 3:93-100, 2004

167. Qu L, Huang S, Baltzis D, Rivas-Estilla A-M, Pluquet O, Hatzoglou M, Koumenis C, Taya Y, Yoshimura A, Koromilas AE. Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3b. Genes Dev, 18:261-277, 2004

12. Carcinogenesis Division

168. Hagihara A, Miyamoto K, Furuta J, Hiraoka N, Wakazono K, Seki S, Fukushima S, Tsao M-S, Sugimura T, Ushijima T. Identification of 27 5' CpG islands aberrantly methylated and 13 genes silenced in human pancreatic cancers. Oncogene, 23:8705-8710, 2004

169. Furuta J, Umebayashi Y, Miyamoto K, Kikuchi K, Otsuka F, Sugimura T, Ushijima T. Promoter methylation profiling of 30 genes in human malignant melanoma. Cancer Sci, 95:962-968, 2004

170. Takada T, Yagi Y, Maekita T, Imura M, Nakagawa S, Tsao S-W, Miyamoto K, Yoshino O, Yasugi T, Taketani Y, Ushijima T. Methylation-associated silencing of the Wnt antagonist SFRP1 gene in human ovarian cancers. Cancer Sci, 95:741-744, 2004

171. Kaneda A, Tsukamoto T, Takamura-Enya T, Watanabe N, Kaminishi M, Sugimura T, Tatematsu M, Ushijima T. Frequent hypomethylation in multiple promoter CpG islands is associated with global hypomethylation, but not with frequent promoter hypermethylation. Cancer Sci, 95:58-64, 2004

172. Kaneda A, Kaminishi M, Sugimura T, Ushijima T. Decreased expression of the seven ARP2/3 complex genes in human gastric cancers. Cancer Lett, 212:203-210, 2004

173. Kaneda A, Wakazono K, Tsukamoto T, Watanabe N, Yagi Y, Tatematsu M, Kaminishi M, Sugimura T, Ushijima T. Lysyl oxidase is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers. Cancer Res, 64:6410-6415, 2004

174. Ushijima T, Sasako M. Focus on gastric cancer. Cancer Cell, 5:121-125, 2004

175. Yamashita S, Nomoto T, Abe M, Tatematsu M, Sugimura T, Ushijima T. Persistence of gene expression changes in stomach mucosae induced by short-term N-methyl-N'-nitro-N-nitrosoguanidine treatment and their presence in stomach cancers. Mutat Res, 549:185-193, 2004

176. Mizoshita T, Inada K, Tsukamoto T, Nozaki K, Joh T, Itoh M, Yamamura Y, Ushijima T, Nakamura S, Tatematsu M. Expression of the intestine-specific transcription factors, Cdx1 and Cdx2, correlates shift to an intestinal phenotype in gastric cancer cells. J Cancer Res Clin Oncol, 130:29-36, 2004

177. Tsukamoto T, Inada K, Tanaka H, Mizoshita T, Mihara M, Ushijima T, Yamamura Y, Nakamura S, homeobox genes, Cdx1 and Cdx2: inverse correlation during progression from gastric/intestinalmixed to complete intestinal metaplasia. J Cancer Res Clin Oncol, 130:135-145, 2004

178. Okochi-Takada E, Ichimura S, Kaneda A, Sugimura T, Ushijima T. Establishment of a detection system for demethylating agents using an endogenous promoter CpG island. Mutat Res, 568:187-194, 2004

179. Hoshi M, Morimura K, Wanibuchi H, Wei M, Okochi E, Ushijima T, Takaoka K, Fukushima S. Noobserved effect levels for carcinogenicity and for in vivo mutagenicity of a genotoxic carcinogen. Toxicol Sci, 81:273-279, 2004

13. Section for Studies on Metastasis

180. Hanai K, Kurokawa T, Minakuchi Y, Maeda M, Nagahara S, Miyata T, Ochiya T, Sano A. Potential of atelocollagen-mediated systemic antisense therapeutics for inflammatory disease. Hum Gene Ther, 15:263-272, 2004

181. Nakamura M, Ando Y, Nagahara S, Sano A, Ochiya T, Maeda S, Kawaji T, Ogawa M, Hirata A, Terazaki H, Haraoka K, Tanihara H, Ueda M, Uchino M, Yamamura K. Targeted conversion of the transthyretin gene in vitro and in vivo. Gene Ther, 11:838-846, 2004

182. Minakuchi Y, Takeshita F, Kosaka N, Sasaki H, Yamamoto Y, Kouno M, Honma K, Nagahara S, Hanai K, Sano A, Kato T, Terada M, Ochiya T. Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo. Nucleic Acids Res, 32:e109, 2004

183. Ochiya T, Quinn G, Yamamoto Y, Teratani T. Liver cells from embryonic stem cells. In: Pediatric Gastroenterology 2004 - Reports from the 2nd World Congress of Pediatric Gastroenterology, Hepatology and Nutrition. Italy, Medimond S.r.l., pp 187-193, 2004

184. Honma K, Miyata T, Ochiya T. The role of atelocollagen-based cell transfection array in high-throughput screening of gene functions and in drug discovery. Curr Drug Discov Techol, 1:287-294, 2004

185. Kai E, Ochiya T. A method for oral DNA delivery with N-acetylated chitosan. Pharm Res, 21:838-843, 2004

186. Hirai K, Sasaki H, Yamamoto H, Sakamoto H, Kubota Y, Kakizoe T, Terada M, Ochiya T. HST-1/FGF-4 protects male germ cells from apoptosis under heat-stress condition. Exp Cell Res, 294:77-85, 2004

187. Sasaki H, Hirai K, Yamamoto H, Tanooka H, Sakamoto H, Iwamoto T, Takahashi T, Terada M, Ochiya T. HST-1/FGF-4 plays a critical role in crypt cell survival and facilitates epithelial cell restitution and proliferation. Oncogene, 23:3681-3688, 2004

14. Section for Studies on Host-Immune Response

188. Yoshida T, Ohnami S, Aoki K. Development of gene therapy to target pancreatic cancer. Cancer Sci, 95:283-289, 2004

189. Okusaka T, Matsumura Y, Aoki K. New approach for pancreatic cancer in Japan. Cancer Chermother Pharmacol, 54 (Suppl 1):S78-S82, 2004

190. Aoki K, Ohnami S, Yoshida T. Suppression of pancreatic and colon cancer cells by antisense K-ras RNA expression vectors. In: M. Ian Philips (ed), Antisense Therapeutics, 2nd edition, USA, Humana Press, pp193-204, 2004

191. Hatanaka K, Suzuki K, Miura Y, Yoshida K, Ohnami S, Kitade Y, Yoshida T, Aoki K. Interferon-a and antisense K-ras RNA combination gene therapy against pancreatic cancer. J Gene Med, 6:1139- 1148, 2004

16. Cancer Prevention Basic Research Project

192. Ohe T, Watanabe T, Wakabayashi K. Mutagens in surface waters: a review. Mutat Res, 567:109-149, 2004

193. Masuda S, Deguchi Y, Masuda Y, Watanabe T, Nukaya H, Terao Y, Takamura T, Wakabayashi K, Kinae N. Genotoxicity of 2-[2-(acetylamino)-4-[bis(2-hydroxyethyl)amino]-5-methoxyphenyl]-5-amino-7-bromo-4-chloro-2H-benzotriazole (PBTA-6) and 4-amino-3,3'-dichloro-5,4'-dinitro-biphenyl (ADDB) in goldfish (Carassius auratus) using the micronucleus test and the comet assay. Mutat Res, 560:33-40, 2004

194. Kawanishi M, Takamura-Enya T, Ermawati R, Shimohara C, Sakamoto M, Matsukawa K, Matsuda T, Murahashi T, Matsui S, Wakabayashi K, Watanabe T, Tashiro Y, Yagi T. Detection of genistein as an estrogenic contaminant of river water in Osaka. Environ Sci Technol, 38:6424-6429, 2004

195. Nishigaki R, Totsuka Y, Takamura-Enya T, Sugimura T, Wakabayashi K. Identification of cytochrome P-450s involved in the formation of APNH from norharman with aniline. Mutat Res, 562:19-25, 2004

196. Kawamori T, Totsuka Y, Uchiya N, Kitamura T, Shibata H, Sugimura T, Wakabayashi K. Carcinogenicity of aminophenylnorharman, a possible novel endogenous mutagen, formed from norharman and aniline, in F344 rats. Carcinogenesis, 25:1967-1972, 2004

197. Totsuka Y, Takamura-Enya T, Nishigaki R, Sugimura T, Wakabayashi K. Mutagens formed from b-carbolines with aromatic amines. J Chromatogr B, 802:135-141, 2004

198. Iidaka T, Sakai H, Tsukamoto T, Yamamoto M, Shirai N, Totsuka Y, Wakabayashi K, Yanai T, Masegi T, Tatematsu M. Detection of initiating and promoting activity of aminophenylnorharman with a fiveweek in vivo initiation assay. J Toxicol Pathol, 17:1-5, 2004

199. Nakatsuru Y, Wakabayashi K, Fujii-Kuriyama Y, Ishikawa T, Kusama K, Ide F. Dibenzo[a,l]pyreneinduced genotoxic and carcinogenic responses are dramatically suppressed in aryl hydrocarbon receptor-deficient mice. Int J Cancer, 112:179-183, 2004

200. Sugimura T, Wakabayashi K, Nakagama H, Nagao M. Heterocyclic amines: Mutagens/carcinogens produced during cooking of meat and fish. Cancer Sci, 95:290-299, 2004

201. Matsubara S, Shibata H, Takahashi M, Ishikawa F, Yokokura T, Sugimura T, Wakabayashi K. Cloning of Mongolian gerbil cDNAs encoding inflammatory proteins, and their expression in glandular stomach during H.pylori infection. Cancer Sci, 95:798-802, 2004

202. Takahashi M, Wakabayashi K. Gene mutations and altered gene expression in azoxymethane-induced colon carcinogenesis in rodents. Cancer Sci, 95:475-480, 2004

203. Kitamura T, Itoh M, Noda T, Matsuura M, Wakabayashi K. Combined effects of cyclooxygenase-1 and cyclooxygenase-2 selective inhibitors on intestinal tumorigenesis in adenomatous polyposis coli gene knockout mice. Int J Cancer, 109:576-580, 2004

204. Shoji Y, Takahashi M, Kitamura T, Watanabe K, Kawamori T, Maruyama T, Sugimoto Y, Negishi M, Narumiya S, Sugimura T, Wakabayashi K. Downregulation of prostaglandin E receptor subtype EP3 during colon cancer development. Gut, 53:1151-1158, 2004

205. Nozawa H, Yoshida A, Tajima O, Katayama M, Sonobe H, Wakabayashi K, Kondo K. Intake of beer inhibits azoxymethane-induced colonic carcinogenesis in male Fischer 344 rats. Int J Cancer, 108:404-411, 2004

206. Watanabe M, Enomoto S, Takamura-Enya T, Nakano T, Koyama K, Sugimura T, Wakabayashi K. Enzymatic properties of pierisin-1 and its N-terminal domain, a guanine-specific ADP-ribosyltransferase from the cabbage butterfly. J Biochem, 135:471-477, 2004

207. Watanabe M, Nakano T, Shiotani B, Matsushima-Hibiya Y, Kiuchi M, Yukuhiro F, Kanazawa T, Koyama K, Sugimura T, Wakabayashi K. Developmental stage-specific expression and tissue distribution of pierisin-1, a guanine-specific ADP-ribosylating toxin, in Pieris rapae. Comp Biochem Physiol A Mol Integr Physiol, 139:125-131, 2004

208. Takamura-Enya T, Watanabe M, Koyama K, Sugimura T, Wakabayashi K. Mono(ADP-ribosyl)ation of the N2 amino groups of guanine residues in DNA by pierisin-2, from the cabbage butterfly, Pieris brassicae. Biochem Biophys Res Commun, 323:579-582, 2004

17. Cancer Proteomics Project

209. Ono M, Hakomori S. Glycosylation defining cancer cell motility and invasiveness. Glycoconj J, 20:71-78, 2004

210. Seike M, Kondo T, Fujii K, Yamada T, Gemma A, Kudoh S, Hirohashi S. Proteomic signature of human cancer cells. Proteomics, 4:2776-2788, 2004

211. Yokoo H, Kondo T, Fujii K, Yamada T, Todo S, Hirohashi S. Proteomic signature corresponding to alpha fetoprotein expression in liver cancer cells. Hepatology, 40:609-617, 2004

18. Cancer Transcriptome Project

212. Inoue S, Izu H, Takaki E, Suzuki H, Shirai M, Yokota Y, Ichikawa H, Fujimoto M, Nakai A. Impaired IgG production in mice deficient for heat shock transcription factor 1. J Biol Chem, 279:38701-38709, 2004

213. Alexander DB, Ichikawa H, Bechberger JF, Valiunas V, Ohki M, Naus CCG, Kunimoto T, Tsuda H, Miller WT, Goldberg GS. Normal cells control the growth of neighboring transformed cells independent of gap junctional communication and Src activity. Cancer Res, 64:1347-1358, 2004

214. Yasuda J, Yokoo H, Yamada T, Kitabayashi I, Sekiya T, Ichikawa H. Nemo-like kinase suppresses a wide range of transcription factors, including nuclear factor-kB. Cancer Sci, 95:52-57, 2004

19. DNA Methylation and Genome Function Project

215. Shiraishi M, Sekiguchi A, Oates AJ, Terry MJ, Miyamoto Y, Sekiya T. Methyl-CpG binding domain column chromatography as a tool for the analysis of genomic DNA methylation. Anal Biochem, 329:1-10, 2004

216. Shiraishi M. Denaturing gradient gel electrophoresis to detect methylation changes in DNA. Methods Mol Biol, 287:219-231, 2004

217. Shiraishi M, Oates AJ, Li X, Chuu YH, Sekiya T. Segregation of partly melted molecules: isolation of CpG islands by polyacrylamide gel electrophoresis. Biol Chem, 385:967-973, 2004

218. Tachibana K, Takeda K, Shiraishi M. 5-Aza-2'-deoxycytidine reactivates the CDH1 gene without influencing methylation of the entire CpG island or histone modification in a human cancer cell line. Proc Japan Acad Ser B, 80:342-348, 2004

219. Hayatsu H, Negishi K, Shiraishi M. DNA methylation analysis: speedup of bisulfite-mediated deamination of cytosine in the genomic sequencing procedure. Proc Jpn Acad Ser B, 80:189-194, 2004

220. Hayatsu H, Negishi K, Shiraishi M. Accelerated bisulfite-deamination of cytosine in the genomic sequencing procedure for DNA methylation analysis. Nucleic Acids Symp Ser, 48:261-262, 2004

221. Shiraishi M, Hayatsu H. High-speed conversion of cytosine to uracil in bisulfite genomic sequencing analysis of DNA methylation. DNA Res, 11:409-415, 2004

20. Tumor Endocrinology Project

222. Kameya T, Tsukada T, Yamaguchi K. Recent advances in MEN1 gene study for pituitary tumor pathogenesis. In: Kontogeorgos G, Kovacs K (eds), Molecular Pathology of the Pituitary, Frontiers of Hormone Research. Switzerland, Karger, pp 265-291, 2004

223. Honda M, Tsukada T, Horiuchi T, Tanaka R, Yamaguchi K, Obara T, Miyakawa H, Yamaji T, Ishibashi M. Primary hyperparathyroidism associated with aldosterone-producing adrenocortical adenoma and breast cancer: relation to MEN1 gene. Intern Med, 43:310-314, 2004

224. Kikuchi M, Ohkura N, Yamaguchi K, Obara T, Tsukada T. Gene dose mapping delineated boundaries of a large germline deletion responsible for multiple endocrine neoplasia type 1. Cancer Lett, 208:81-88, 2004

225. Yaguchi H, Ohkura N, Takahashi M, Nagamura Y, Kitabayashi I, Tsukada T. Menin missense mutants associated with multiple endocrine neoplasia type 1 are rapidly degraded via the ubiquitin-proteasome pathway. Mol Cell Biol, 24:6569-6580, 2004

226. Sowa H, Kaji H, Kitazawa R, Kitazawa S, Tsukamoto T, Yano S, Tsukada T, Canaff L, Hendy GN, Sugimoto T, Chihara K. Menin inactivation leads to loss of transforming growth factor b inhibition of parathyroid cell proliferation and parathyroid hormone secretion. Cancer Res, 64:2222-2228, 2004

227. Hanada T, Toshinai K, Date Y, Kajimura N, Tsukada T, Hayashi Y, Kangawa K, Nakazato M. Upregulation of ghrelin expression in cachectic nude mice bearing human melanoma cells. Metabolism, 53:84-88, 2004

21. Tumor Suppression and Functional Genomics Project

228. Surace EI, Lusis E, Murakami Y, Scheithauer BW, Perry A, Gutmann DH. Loss of tumor suppressor in lung cancer-1 (TSLC1) expression in meningioma correlates with increased malignancy grade and reduced patient survival. J Neuropathol Exp Neurol, 63:1015-1027, 2004

229. Lung HL, Cheng Y, Kumaran MK, Liu ET-B, Murakami Y, Chan CY, Yau WL, Ko JMY, Stanbridge EJ, Lung ML. Fine mapping of the 11q22-23 tumor suppressive region and involvement of TSLC1 in nasopharyngeal carcinoma. Int J Cancer, 112:628-635, 2004

230. Saino M, Maruyama T, Sekiya T, Kayama T, Murakami Y. Inhibition of angiogenesis in human glioma cell lines by antisense RNA from the soluble guanylate cyclase genes, GUCY1A3 and GUCY1B3. Oncol Rep, 12:47-52, 2004

231. Murakami Y, Isogai K, Tomita H, Sakurai-Yageta M, Maruyama T, Hidaka A, Nose K, Sugano K, Kaneko A. Detection of allelic imbalance in the gene expression of hMSH2 or RB1 in lymphocytes from pedigrees of hereditary, nonpolyposis, colorectal cancer and retinoblastoma by an RNA difference plot. J Hum Genet, 49:635-641, 2004

232. Tsuchiya N, Kuroki K, Fujimoto M, Murakami, Y, Tedder TF, Tokunaga K, Takehara K, Sato S. Association of a functional CD19 polymorphism with susceptibility to systemic sclerosis. Arthritis Rheum, 50:4002-4007, 2004

22. Pathology Division, East

233. Hasebe T, Sasaki S, Imoto S, Ochiai A. Prognostic significance of the intra-vessel tumor characteristics of invasive ductal carcinoma of the breast: a prospective study. Virchows Arch, 444:20-27, 2004

234. Hasebe T, Sasaki S, Imoto S, Ochiai A. Histological characteristics of tumor in vessels and lymph nodes are significant predictors of progression of invasive ductal carcinoma of the breast: a prospective study. Hum Pathol, 35:298-308, 2004

235. Yonou H, Yokose T, Yoshikawa T, Kanomata N, Kamijo T, Hasebe T, Nagai K, Ito H, Yamasaki A, Hatano T, Ogawa Y, Emura M, Ochiai A. Engraftment of adult human lung tissue in nonobese diabetic/severe combined immunodeficient mice: a novel lung epithelial regeneration model. Pathobiology, 71:93-102, 2004

236. Yonou H, Ochiai A, Goya M, Kanomata N, Hokama S, Morozumi M, Sugaya K, Hatano T, Ogawa Y. Intraosseous growth of human prostate cancer in implanted adult human bone: Relationship of prostate cancer cells to osteoclasts in osteoblastic metastatic lesions. Prostate, 58:406-413, 2004

237. Goya M, Miyamoto S, Nagai K, Ohki Y, Nakamura K, Shitara K, Maeda H, Sangai T, Kodama K, Endoh Y, Ishii G, Hasebe T, Yonou H, Hatano T, Ogawa Y, Ochiai A. Growth inhibition of human prostate cancer cells in human adult bone implanted into nonobese diabetic/severe combined immunodeficient mice by a ligand-specific antibody to human insulin-like growth factors. Cancer Res, 64:6252-6258, 2004

238. Miyamoto S, Yano K, Sugimoto S, Ishii G, Hasebe T, Endoh Y, Kodama K, Goya M, Chiba T, Ochiai A. Matrix metalloproteinase-7 facilitates insulin-like growth factor bioavailability through its proteinase activity on insulin-like growth factor binding protein 3. Cancer Res, 64:665-671, 2004

239. Nakamura M, Miyamoto S, Maeda H, Zhang S, Sangai T, Ishii G, Hasebe T, Endoh Y, Saito N, Asaka M, Ochiai A. Low levels of insulin-like growth factor type 1 receptor expression at cancer cell membrane predict liver metastasis in Dukes' C human colorectal cancers. Clin Cancer Res, 10:8434-8441, 2004

240. Aoyagi Y, Oda T, Kinoshita T, Nakahashi C, Hasebe T, Ohkohchi N, Ochiai A. Overexpression of TGF-b by infiltrated granulocytes correlates with the expression of collagen mRNA in pancreatic cancer. Br J Cancer, 91:1316-1326, 2004

241. Yoh K, Ishii G, Yokose T, Minegishi Y, Tsuta K, Goto K, Nishiwaki Y, Kodama T, Suga M, Ochiai A. Breast cancer resistance protein impacts clinical outcome in platinum-based chemotherapy for advanced non-small cell lung cancer. Clin Cancer Res, 10:1691-1697, 2004

242. Kim YH, Ishii G, Goto K, Nagai K, Tsuta K, Shiono S, Nitadori J, Kodama T, Nishiwaki Y, Ochiai A. Dominant papillary subtype is a significant predictor of the response to gefitinib in adenocarcinoma of the lung. Clin Cancer Res, 10:7311-7317, 2004

243. Tsuta K, Ishii G, Yoh K, Nitadori J, Hasebe T, Nishiwaki Y, Endoh Y, Kodama T, Nagai K, Ochiai A. Primary lung carcinoma with signet-ring cell carcinoma components: clinicopathological analysis of 39 cases. Am J Surg Pathol, 28:868-874, 2004

244. Tahara M, Ochiai A, Fujimoto J, Boku N, Yasui W, Ohtsu A, Tahara E, Yoshida S. Expression of thymidylate synthase, thymidine phosphorylase, dihydropyrimidine dehydrogenase, E2F-1, Bak, Bcl-X, and Bcl-2, and clinical outcomes for gastric cancer patients treated with bolus 5-fluorouracil. Oncol Rep, 11:9-15, 2004

245. Yoshikawal T, Aoyagi Y, Kodama K, Kamijo T, Yonou H, Yokose T, Ishii G, Oda T, Takamochi K, Nagai K, Nishiwaki Y, Shimizu N, Ochiai A. Topographical distribution of allelic loss in individual lung adenocarcinomas with lymph node metastases. Mod Pathol, 17:204-213, 2004

246. Lim S-C, Zhang S, Ishii G, Endoh Y, Kodama K, Miyamoto S, Hayashi R, Ebihara S, Cho J-S, Ochiai A. Predictive markers for late cervical metastasis in stage I and II invasive squamous cell carcinoma of the oral tongue. Clin Cancer Res, 10:166-172, 2004

247. Wada N, Imoto S, Hasebe T, Ochiai A, Ebihara S, Moriyama N. Evaluation of intraoperative frozen section diagnosis of sentinel lymph nodes in breast cancer. Jpn J Clin Oncol, 34:113-117, 2004

248. Imoto S, Wada N, Murakami K, Hasebe T, Ochiai A, Ebihara S. Prognosis of breast cancer patients treated with sentinel node biopsy in Japan. Jpn J Clin Oncol, 34:452-456, 2004

249. Takahashi H, Oda T, Hasebe T, Aoyagi Y, Kinoshita T, Konishi M, Nakagohri T, Inoue K, Takahashi S, Kawahira H, Monden M, Ochiai A. Biologically different subgroups of invasive ductal carcinoma of the pancreas: Dpc4 status according to the ratio of intraductal carcinoma components. Clin Cancer Res, 10:3772-3779, 2004

250. Nakahashi C, Kinoshita T, Konishi M, Nakagohri T, Inoue K, Oda T, Yoshida J, Hasebe T, Ochiai A. Long-term survival achieved by repeated resections of metachronous pulmonary and adrenal metastases of a-fetoprotein-producing gastric cancer: report of a case. Surg Today, 34:784-787, 2004

251. Miyamoto S, Endoh Y, Hasebe T, Ishii G, Kodama K, Goya M, Ono M, Saitoh N, Chiba T, Ochiai A. Nuclear b-catenin accumulation as a prognostic factor in Dukes' D human colorectal cancers. Oncol Rep, 12:245-251, 2004

252. Shiono S, Yoshida J, Nishimura M, Nitadori J, Ishii G, Nishiwaki Y, Nagai K. Late pulmonary metastasis of renal cell carcinoma resected 25 years after nephrectomy. Jpn J Clin Oncol, 34:46-49, 2004

253. Shimizu K, Yoshida J, Nagai K, Nishimura M, Yokose T, Ishii G, Nishiwaki Y. Visceral pleural invasion classification in non-small cell lung cancer: a proposal on the basis of outcome assessment. J Thorac Cardiovasc Surg, 127:1574-1578, 2004

23. Investigative Treatment Division and Cancer Physiology Project

254. Matsumura Y, Gotoh M, Muro K, Yamada Y, Shirao K, Okuwa M, Matsumoto S, Miyata Y, Ohkura H, Chin K, Baba S, Yamao T, Kannami A, Takamatsu Y, Ito K, Takahashi K. Phase I and pharmacokinetic study of MCC-465, a doxorubicin (DXR) encapsulated in PEG immunoliposome, in patients with metastatic stomach cancer. Ann Oncol, 15:517-525, 2004

255. Hamaguchi T, Matsumura Y, Nakanishi Y, Muro K, Yamada Y, Shimada Y, Shirao K, Niki H, Hosokawa S, Tagawa T, Kakizoe T. Antitumor effect of MCC-465, pegylated liposomal doxorubicin tagged with newly developed monoclonal antibody GAH, in colorectal cancer xenografts. Cancer Sci, 95:608-613, 2004

256. Matsumura Y, Hamaguchi T, Ura T, Muro K, Yamada Y, Shimada Y, Shirao K, Okusaka T, Ueno H, Ikeda M, Watanabe N. Phase I clinical trial and pharmacokinetic evaluation of NK911, a micelleencapsulated doxorubicin. Br J Cancer, 91:1775-1781, 2004

257. Nishiyama N, Okazaki S, Cabral H, Miyamoto M, Kato Y, Sugiyama Y, Nishio K, Matsumura Y, Kataoka K. Novel cisplatin-incorporated polymeric micelles can eradicate solid tumors in mice. Cancer Res, 63:8977-8983, 2003

258. Lu J, Kunimoto S, Yamazaki Y, Kaminishi M, Esumi H. Kigamicin D, a novel anticancer agent based on a new anti-austerity strategy targeting cancer cells' tolerance to nutrient starvation. Cancer Sci, 95:547-552, 2004

259. Esumi H, Lu J, Kurashima Y, Hanaoka T. Antitumor activity of pyrvinium pamoate, 6-(dimethylamino)-2-[2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl]-1-methyl-quinolinium pamoate salt, showing preferential cytotoxicity during glucose starvation. Cancer Sci, 95:685-690, 2004

260. Suzuki A, Kusakai G, Kishimoto A, Shimojo Y, Ogura T, Lavin MF, Esumi H. IGF-1 phosphorylates AMPK-a subunit in ATM-dependent and LKB1-independent manner. Biochem Biophys Res Commun, 324:986-992, 2004

261. Suzuki A, Kusakai G, Kishimoto A, Shimojo Y, Miyamoto S, Ogura T, Ochiai A, Esumi H. Regulation of caspase-6 and FLIP by the AMPK family member ARK5. Oncogene, 23:7067-7075, 2004

262. Kusakai G, Suzuki A, Ogura T, Miyamoto S, Ochiai A, Kaminishi M, Esumi H. ARK5 expression in colorectal cancer and its implications for tumor progression. Am J Pathol, 164:987-995, 2004

263. Suzuki A, Lu J, Kusakai G, Kishimoto A, Ogura T, Esumi H. ARK5 is a tumor invasion-associated factor downstream of Akt signaling. Mol Cell Biol, 24:3526-3535, 2004

264. Kusakai G, Suzuki A, Ogura T, Kaminishi M, Esumi H. Strong association of ARK5 with tumor invasion and metastasis. J Exp Clin Cancer Res, 23:263-268, 2004

265. Nomura S, Kaminishi M, Takagi N, Esumi H. Analysis of promoter region of X-linked pgk-1 gene polymorphisms: evidence for polyclonality of adult mouse gastric glands. Dig Dis Sci, 49:218-223, 2004

266. Takamochi K, Ogura T, Yokose T, Ochiai A, Nagai K, Nishiwaki Y, Suzuki K, Esumi H. Molecular analysis of the TSC1 gene in adenocarcinoma of the lung. Lung Cancer, 46:271-281, 2004

267. Muto M, Nakane M, Katada C, Sano Y, Ohtsu A, Esumi H, Ebihara S, Yoshida S. Squamous cell carcinoma in situ in oropharyngeal and hypopharyngeal mucosal sites. Cancer, 101:1375-1381, 2004

24. Psycho-Oncology Division

268. Akechi T, Okuyama T, Sugawara Y, Nakano T, Shima Y, Uchitomi Y. Major depression, adjustment disorders, and post-traumatic stress disorder in terminally ill cancer patients: associated and predictive factors. J Clin Oncol, 22:1957-1965, 2004

269. Murakami Y, Okamura H, Sugano K, Yoshida T, Kazuma K, Akechi T, Uchitomi Y. Psychologic distress after disclosure of genetic test results regarding hereditary nonpolyposis colorectal carcinoma. Cancer, 101:395-403, 2004

270. Inagaki M, Matsuoka Y, Sugahara Y, Nakano T, Akechi T, Fujimori M, Imoto S, Murakami K, Uchitomi Y. Hippocampal volume and first major depressive episode after cancer diagnosis in breast cancer survivors. Am J Psychiatry, 161:2263-2270, 2004

271. Suzuki S, Akechi T, Kobayashi M, Taniguchi K, Goto K, Sasaki S, Tsugane S, Nishiwaki Y, Miyaoka H, Shima Y, Uchitomi Y. Daily omega-3 fatty acid intake and depression in Japanese patients with newly diagnosed lung cancer. Br J Cancer, 90:787-793, 2004

272. Akechi T, Sakuma K, Okamura M, Akizuki N, Oba A, Nakano T, Uchitomi Y. Post traumatic symptoms experienced by a nurse after a patient suicide. Jpn J Gen Hosp Psychiatry, 16:49-54, 2004

273. Akechi T, Okuyama T, Sugawara Y, Nakano T, Shima Y, Uchitomi Y. Suicidality in terminally ill Japanese patients with cancer. Cancer, 100:183-191, 2004

274. Morita T, Kawa M, Honke Y, Kohara H, Maeyama E, Kizawa Y, Akechi T, Uchitomi Y. Existential concerns of terminally ill cancer patients receiving specialized palliative care in Japan. Support Care Cancer, 12:137-140, 2004

275. Morita T, Hyodo I, Yoshimi T, Ikenaga M, Tamura Y, Yoshizawa A, Shimada A, Akechi T, Adachi I, the Japan Palliative Oncology Study Group. Incidence and underlying etiologies of bronchial secretion in terminally ill cancer patients: a multicenter, prospective, observational study. J Pain Symptom Manage, 27:533-539, 2004

276. Morita T, Akechi T, Ikenaga M, Kizawa Y, Kohara H, Mukaiyama T, Nakaho T, Nakashima N, Shima Y, Matsubara T, Fujimori M, Uchitomi Y. Communication about the ending of anticancer treatment and transition to palliative care. Anal Oncol, 15:1551-1557, 2004

277. Morita T, Ikenaga M, Adachi I, Narabayashi I, Kizawa Y, Honke Y, Kohara H, Mukaiyama T, Akechi T, Kurihara Y, Uchitomi Y. Concerns of family members of patients receiving palliative sedation therapy. Support Care Cancer, 12:885-889, 2004

278. Morita T, Ikenaga M, Adachi I, Narabayashi I, Kizawa Y, Honke Y, Kohara H, Mukaiyama T, Akechi T, Uchitomi Y. Family experience with palliative sedation therapy for terminally ill cancer patients. J Pain Symptom Manage, 28:557-565, 2004

279. Okuyama T, Wang XS, Akechi T, Mendoza TR, Hosaka T, Cleeland CS, Uchitomi Y. Adequacy of cancer pain management in a Japanese Cancer Hospital. Jpn J Clin Oncol, 34:37-42, 2004

25. Epidemiology and Prevention Division

280. Tsugane S, Sasazuki S, Kobayashi M, Sasaki S. Salt and salted food intake and subsequent risk of gastric cancer among middle-aged Japanese men and women. Br J Cancer, 90:128-134, 2004

281. Inoue M, Hanaoka T, Sasazuki S, Sobue T, Tsugane S, the JPHC Study Group. Impact of tobacco smoking on subsequent cancer risk among middle-aged Japanese men and women: data from a largescale population-based cohort study in Japan: the JPHC study. Prev Med, 38:516-522, 2004

282. Kim MK, Sasaki S, Sasazuki S, Tsugane S, Japan Public Health Center-based Prospective Study Group. Prospective study of three major dietary patterns and risk of gastric cancer in Japan. Int J Cancer, 110:435-442, 2004

283. Iso H, Baba S, Mannami T, Sasaki S, Okada K, Konishi M, Tsugane S, the JPHC Study Group. Alcohol consumption and risk of stroke among middle-aged men: the JPHC Study Cohort I. Stroke, 35:1124-1129, 2004

284. Mannami T, Iso H, Baba S, Sasaki S, Okada K, Konishi M, Tsugane S, Japan Public Health Center-Based Prospective Study on Cancer and Cardiovascular Disease Group. Cigarette smoking and risk of stroke and its subtypes among middle-aged Japanese men and women: the JPHC Study Cohort I. Stroke, 35:1248-1253, 2004

285. Inoue M, Sobue T, Tsugane S, for the JPHC Study Group. Impact of body mass index on the risk of total cancer incidence and mortality among middle-aged Japanese: data from a large-scale populationbased cohort study-the JPHC study. Cancer Causes Control, 15:671-680, 2004

286. Sasazuki S, Inoue M, Hanaoka T, Yamamoto S, Sobue T, Tsugane S, for the JPHC Study Group. Green tea consumption and subsequent risk of gastric cancer by subsite: the JPHC Study. Cancer Causes Control, 15:483-491, 2004

287. Kobayashi M, Tsubonp Y, Otani T, Hanaoka T, Sobue T, Tsugane S, the JPHC Study Group. Fish, long-chain n-3 polyunsaturated fatty acids, and risk of colorectal cancer in middle-aged Japanese: the JPHC study. Nutr Cancer, 49:32-40, 2004

288. Kim MK, Sasaki S, Sasazuki S, Okubo S, Hayashi M, Tsugane S. Long-term vitamin C supplementation has no markedly favourable effect on serum lipids in middle-aged Japanese subjects. Br J Nutr, 91:81-90, 2004

289. Iwasaki M, Polidoro Mameri C, Hamada GS, Tsugane S. Cancer mortality among Japanese immigrants and their descendants in the state of Sao Paulo, Brazil, 1999-2001. Jpn J Clin Oncol, 34:673-680, 2004

290. Machida-Montani A, Sasazuki S, Inoue M, Natsukawa S, Shaura K, Koizumi Y, Kasuga Y, Hanaoka T, Tsugane S. Association of Helicobacter pylori infection and environmental factors in non-cardia gastric cancerin Japan. Gastric Cancer, 7:46-53, 2004

291. Tsukino H, Hanaoka T, Otani T, Iwasaki M, Kobayashi M, Hara M, Natsukawa S, Shaura K, Koizumi Y, Kasuga Y, Tsugane S. hOGG1 Ser326Cys polymorphism, interaction with environmental exposures, and gastric cancer risk in Japanese populations. Cancer Sci, 95:977-983, 2004

292. Hashimoto H, Hanaoka T, Kobayashi M, Tsugane S. Analytical method of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in human hair by column-switching liquid chromatography-mass spectrometry. J Chromatogr B, 803:209-213, 2004

293. Tao H, Shinmura K, Hanaoka T, Natsukawa S, Shaura K, Koizumi Y, Kasuga Y, Ozawa T, Tsujinaka T, Li Z, Yamaguchi S, Yokota J, Sugimura H, Tsugane S. A novel splice-site variant of the base excision repair gene MYH is associated with production of an aberrant mRNA transcript encoding a truncated MYH protein not localized in the nucleus. Carcinogenesis, 25:1859-1866, 2004

294. Hirabayashi N, Wada K, Kimura T, Hirabayashi E, Mishima S, Yukioka T, Hanaoka T, Iimori M. Prevalence of substance abuse among patients with physical diseases seen in an emergency room in Japan. Am J Addict, 13:398-404, 2004

26. Statistics and Cancer Control Division

295. Liu Y, Kaneko S, Sobue T. Trends in reported incidences of gastric cancer by tumour location, from 1975 to 1989 in Japan. Int J Epidemiol, 33:808-815, 2004

296. Marugame T, Hamashima C. Cancer statistics digest. Mortality trend of uterine cancer in Japan: 1960-2000. Jpn J Clin Oncol, 34:55-59, 2004

297. Imamura Y, Mizuno S. Cancer statistics digest. Mortality trends of rectal cancer in Japan: 1960-2000. Jpn J Clin Oncol, 34:107-111, 2004

298. Kamo K, Sobue T. Cancer statistics digest. Mortality trend for 'oral cavity and pharynx' and 'larynx' cancer in Japan: 1960-2000. Jpn J Clin Oncol, 34:162-164, 2004

299. Yoshimi I, Kaneko S. Cancer statistics digest. Mortality trend of hematologic and lymphatic malignancy (lymphoma, multiple myeloma and leukemia) in Japan: 1960-2000. Jpn J Clin Oncol, 34:218-225, 2004

300. Yoshimi I, Marugame T. Cancer statistics digest. Mortality trend of central nervous system, eye, thyroid, skin, connective tissue and bone in Japan: 1960-2000. Jpn J Clin Oncol, 34:287-293, 2004

301. Yoshimi I, Sobue T. Cancer statistics digest. Mortality trend in Japan with special reference to birth cohort-all sites: (1960-2000). Jpn JClin Oncol, 34:360-362, 2004

302. Marugame T, Sobue T. Cancer statistics digest. Mortality trend of mouth and pharynx, esophagus, stomach, larynx and lung cancer in Japan by birth cohort. Jpn J Clin Oncol, 34:432-438, 2004

303. Imamura Y, Sobue T. Cancer statistics digest. Mortality trend of colon, rectal, liver, "gallbladder and biliary tract" and pancreas cancer in Japan by birth cohort. Jpn J Clin Oncol, 34:491-493, 2004

304. Kamo K, Sobue T. Cancer statistics digest. Mortality trend of prostate, breast, uterus, ovary, bladder and "kidney and other urinary tract" cancer in Japan by birth cohort. Jpn J Clin Oncol, 34:561-563, 2004

305. Yoshimi I, Mizuno S. Cancer statistics digest. Mortality trends of hematologic neoplasms (lymphoma, myeloma, and leukemia) in Japan (1960-2000): with special reference to birth cohort. Jpn J Clin Oncol, 34:634-637, 2004

306. Yoshimi I, Sobue T. Cancer statistics digest. International comparison of cancer statistics: Eastern Asia. Jpn J Clin Oncol, 34:700-702, 2004

307. Yoshimi I, Sobue T. Cancer statistics digest. International comparison in cancer statistics: Eastern Asia (2). Jpn J Clin Oncol, 34:759-763, 2004

308. Arisawa K, Sobue T, Yoshimi I, Soda M, Shirahama S, Doi H, Katamine S, Saito H, Urata M. Human T-lymphotropic virus type-I infection, survival and cancer risk in southwestern Japan: a prospective cohort study. Cancer Causes Control, 14:889-896, 2003

309. Liu Y, Sobue T, Otani T, Tsugane S. Vegetables, fruit consumption and risk of lung cancer among middle-aged Japanese men and women: JPHC study. Cancer Causes Control, 15:349-357, 2004

310. Marugame T, Sobue T, Nakayama T, Suzuki T, Kuniyoshi H, Sunagawa K, Genka K, Nishizawa N, Natsukawa S, Kuwahara O, Tsubura E. Filter cigarette smoking and lung cancer risk; a hospital-based case-control study in Japan. Br J Cancer, 90:646-651, 2004

311. Onda T, Kamura T, Ishizuka N, Katsumata N, Fukuda H, Yoshikawa H. Feasibility study of neoadjuvant chemotherapy followed by interval cytoreductive surgery for stage III/IV ovarian, tubal and peritoneal cancers: Japan Clinical Oncology Group Study JCOG0206. Jpn J Clin Oncol, 34:43-45, 2004

312. Sano T, Sasako M, Yamamoto S, Nashimoto A, Kurita A, Hiratsuka M, Tsujinaka T, Kinoshita T, Arai K, Yamamura Y, Okajima K. Gastric cancer surgery: morbidity and mortality results from a prospective randomized controlled trial comparing D2 and extended para-aortic lymphadenectomy-Japan Clinical Oncology Group study 9501. J Clin Oncol, 22:2767-2773, 2004

313. Yamao T, Shimada Y, Shirao K, Ohtsu A, Ikeda N, Hyodo I, Saito H, Iwase H, Tsuji Y, Tamura T, Yamamoto S, Yoshida S. Phase II study of sequential methotrexate and 5-fluorouracil chemotherapy against peritoneally disseminated gastric cancer with malignant ascites: a report from the Gastrointestinal Oncology Study Group of the Japan Clinical Oncology Group, JCOG 9603 Trial. Jpn J Clin Oncol, 34:316-322, 2004

314. Ishida K, Ando N, Yamamoto S, Ide H, Shinoda M. Phase II study of cisplatin and 5-fluorouracil with concurrent radiotherapy in advanced squamous cell carcinoma of the esophagus: a Japan Esophageal Oncology Group (JEOG)/Japan Clinical Oncology Group trial (JCOG9516). Jpn J Clin Oncol, 34:615- 619, 2004

315. Yoshida M, Ohtsu A, Boku N, Miyata Y, Shirao K, Shimada Y, Hyodo I, Koizumi W, Kurihara M, Yoshida S, Yamamoto S. Long-term survival and prognostic factors in patients with metastatic gastric cancers treated with chemotherapy in the Japan Clinical Oncology Group (JCOG) study. Jpn J Clin Oncol, 34:654-659, 2004

316. Takano T, Ohe Y, Kusumoto M, Tateishi U, Yamamoto S, Nokihara H, Yamamoto N, Sekine I, Kunitoh H, Tamura T, Kodama T, Saijo N. Risk factors for interstitial lung disease and predictive factors for tumor response in patients with advanced non-small cell lung cancer treated with gefitinib. Lung Cancer, 45:93-104, 2004

317. Fujita S, Shimoda T, Yoshimura K, Yamamoto S, Akasu T, Moriya Y. Prospective evaluation of prog nostic factors in patients with colorectal cancer undergoing curative resection. J Surg Oncol, 84:127-131, 2003

Central Animal Laboratory

318. Luo B, Murakami M, Fukuda M, Fujioka A, Yanagihara K, Sairenji T.Characterization of Epstein-Barr virus infection in a human signet ring cell gastric carcinoma cell line, HSC-39. Microbes Infect, 6:429-439, 2004

319. Namiki Y, Namiki T, Date M, Yanagihara K, Yashiro M, Takahashi H. Enhanced photodynamic antitumor effect on gastric cancer by a novel photosensitive stealth liposome. Pharmacol Res, 50:65-76, 2004

320. Yanagihara K, Tanaka H, Takigahira M, Ino Y, Yamaguchi Y, Toge T, Sugano K, Hirohashi S. Establishment of two cell lines from human gastric scirrhous carcinoma that possess the potential to metastasize spontaneously in nude mice. Cancer Sci, 95:575-582, 2004

President Emeritus

321. Sugimura T. Establishment of the concept that cancer is a disease of DNA: Serendipitous discoveries in my research career concerning the science of carcinogenesis. In: Semenza G, Turner AJ (eds), A History of Biochemistry. The Netherlands, Elsevier B.V., pp.355-392, 2004