1. Pathology Division

1. Nakagawa T, Kanai Y, Ushijima S, Kitamura T, Kakizoe T, Hirohashi S. DNA hypermethylation on multiple CpG islands associated with increased DNA methyltransferase DNMT1 protein expression during multistage urothelial carcinogenesis. J Urol, 173:1767-1771, 2005

2. Peng D-F, Kanai Y, Sawada M, Ushijima S, Hiraoka N, Kosuge T, Hirohashi S. Increased DNA methyltransferase 1 (DNMT1) protein expression in precancerous conditions and ductal carcinomas of the pancreas. Cancer Sci, 96:403-408, 2005

3. Nakagawa T, Kanai Y, Ushijima S, Kitamura T, Kakizoe T, Hirohashi S. DNA hypomethylation on pericentromeric satellite regions significantly correlates with loss of heterozygosity on chromosome 9 in urothelial carcinomas. J Urol, 173:243-246, 2005

4. Izumi H, Inoue J, Yokoi S, Hosoda H, Shibata T, Sunamori M, Hirohashi S, Inazawa J, Imoto I. Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers. Hum Mol Genet, 14:997-1007, 2005

5. Chihara Y, Sugano K, Kobayashi A, Kanai Y, Yamamoto H, Nakazono M, Fujimoto H, Kakizoe T, Fujimoto K, Hirohashi S, Hirao Y. Loss of blood group A antigen expression in bladder cancer caused by allelic loss and/or methylation of the ABO gene. Lab Invest, 85:895-907, 2005

6. Nishizawa A, Nakanishi Y, Yoshimura K, Sasajima Y, Yamazaki N, Yamamoto A, Hanada K, Kanai Y, Hirohashi S. Clinicopathologic significance of dysadherin expression in cutaneous malignant melanoma: immunohistochemical analysis of 115 patients. Cancer, 103:1693-1700, 2005

7. Tsuda H, Tani Y, Weisenberger J, Kitada S, Hasegawa T, Murata T, Tamai S, Hirohashi S, Matsubara O, Natori T. Frequent KIT and epidermal growth factor receptor overexpressions in undifferentiated-type breast carcinomas with 'stem-cell-like' features. Cancer Sci, 96:333-339, 2005

8. Nakagawa K, Matsuno Y, Kunitoh H, Maeshima A, Asamura H, Tsuchiya R. Immunohistochemical KIT (CD117) expression in thymic epithelial tumors. Chest, 128:140-144, 2005

9. Takamura M, Ichida T, Matsuda Y, Kobayashi M, Yamagiwa S, Genda T, Shioji K, Hashimoto S, Nomoto M, Hatakeyama K, Ajioka Y, Sakamoto M, Hirohashi S, Aoyagi Y. Reduced expression of liver-intestine cadherin is associated with progression and lymph node metastasis of human colorectal carcinoma. Cancer Lett, 212:253-259, 2004

10. Nitori N, Ino Y, Nakanishi Y, Yamada T, Honda K, Yanagihara K, Kosuge T, Kanai Y, Kitajima M, Hirohashi S. Prognostic significance of tissue factor in pancreatic ductal adenocarcinoma. Clin Cancer Res, 11:2531-2539, 2005

11. Nakanishi K, Sakamoto M, Yamasaki S, Todo S, Hirohashi S. Akt phosphorylation is a risk factor for early disease recurrence and poor prognosis in hepatocellular carcinoma. Cancer, 103:307-312, 2005

12. Oikawa T, Ojima H, Yamasaki S, Takayama T, Hirohashi S, Sakamoto M. Multistep and multicentric development of hepatocellular carcinoma: histological analysis of 980 resected nodules. J Hepatol, 42:225-229, 2005

13. Ojima H, Hasegawa T, Matsuno Y, Sakamoto M. Extramedullary myeloid tumour (EMMT) of the gallbladder. J Clin Pathol, 58:211-213, 2005

14. Takahashi F, Tsuta K, Matsuno Y, Takahashi K, Toba M, Sato K, Uekusa T, Izumi H, Nakamura K, Hirose S, Fukuchi Y. Adenocarcinoma of the thymus: mucinous subtype. Hum Pathol, 36:219-223, 2005

15. Sakamoto Y, Kosuge T, Shimada K, Sano T, Ojima H, Yamamoto J, Yamasaki S, Takayama T, Makuuchi M. Prognostic factors of surgical resection in middle and distal bile duct cancer: an analysis of 55 patients concerning the significance of ductal and radial margins. Surgery, 137:396-402, 2005

16. Esaki M, Shimada K, Sano T, Sakamoto Y, Kosuge T, Ojima H. Surgical results for hepatocellular carcinoma with bile duct invasion: a clinicopathologic comparison between macroscopic and microscopic tumor thrombus. J Surg Oncol, 90:226-232, 2005

17. Tsuda H, Mikami Y, Kaku T, Hasegawa T, Akiyama F, Ohishi Y, Sasajima Y, Kasamatsu T. Reproducible and clinically meaningful differential diagnosis is possible between lobular endocervical glandular hyperplasia and 'adenoma malignum' based on common histopathological criteria. Pathol Int, 55:412-418, 2005

18. Tateishi U, Hasegawa T, Yamamoto S, Yamaguchi U, Yokoyama R, Kawamoto H, Satake M, Arai Y. Incidence of multiple primary malignancies in a cohort of adult patients with soft tissue sarcoma. Jpn J Clin Oncol, 35:444-452, 2005

19. Hosokawa A, Maeda T, Tateishi U, Satake M, Iwata R, Ojima H, Arai Y. Hepatic hemangioma presenting atypical radiologic findings: a case report. Radiat Med, 23:371-375, 2005

20. Yamaguchi J, Ojima H, Hiraoka N, Hasegawa T. Poorly differentiated hepatocellular carcinoma with unusual tubular structures. J Clin Pathol, 58:1342-1344, 2005

2. Biochemistry Division

21. Nakagama H, Nakanishi M, Ochiai M. Modeling human colon cancer in rodents using a food-borne carcinogen, PhIP. Cancer Sci, 96:627-636, 2005

22. Ochiai M, Watanabe M, Nakanishi M, Taguchi A, Sugimura T, Nakagama H. Differential staining of dysplastic aberrant crypt foci in the colon facilitates prediction of carcinogenic potentials of chemicals in rats. Cancer Lett, 220:67-74, 2005

23. Suzuki R, Kohno H, Sugie S, Nakagama H, Tanaka T. Strain differences in the susceptibility to azoxymethane and dextran sodium sulfate-induced colon carcinogenesis in mice. Carcinogenesis, 27:162-169, 2005

24. Osawa E, Nakajima A, Fujisawa T, Kawamura Y, Toyama-Sorimachi N, Nakagama H, Dohi T. Predominant T helper type 2-inflammatory responses promte murine colon cancers. Int J Cancer, 118:2232-2236, 2005

25. Fukuda H, Katahira M, Tanaka E, Enokizono Y, Tsuchiya N, Higuchi K, Nagao M, Nakagama H. Unfolding of higher DNA structures formed by the d(CGG) triplet repeat by UP1 protein. Genes Cells, 10:953-962, 2005

26. Ushigome M, Ubagai T, Fukuda H, Tsuchiya N, Sugimura T, Takatsuka J, Nakagama H. Up-regulation of hnRNP A1 gene in sporadic human colorectal cancers. Int J Oncol, 26:635-640, 2005

3. Chemotherapy Division and Cancer Proteomics Project

27. Naishiro Y, Yamada T, Idogawa M, Honda K, Takada M, Kondo T, Imai K, Hirohashi S. Morphological and transcriptional responses of untransformed intestinal epithelial cells to an oncogenic b-catenin protein. Oncogene, 24:3141-3153, 2005

28. Idogawa M, Yamada T, Honda K, Sato S, Imai K, Hirohashi S. Poly(ADP-ribose) polymerase-1 is a component of the oncogenic T-cell factor-4/b-catenin complex. Gastroenterology, 128:1919-1936, 2005

29. Sato S, Idogawa M, Honda K, Fujii G, Kawashima H, Takekuma K, Hoshika A, Hirohashi S, Yamada T. b-catenin interacts with the FUS proto-oncogene product and regulates pre-mRNA splicing. Gastroenterology, 129:1225-1236, 2005

30. Hayashida Y, Honda K, Idogawa M, Ino Y, Ono M, Tsuchida A, Aoki T, Hirohashi S, Yamada T. E-cadherin regulates the association between b-catenin and actinin-4. Cancer Res, 65:8836-8845, 2005

31. Honda K, Yamada T, Hayashida Y, Idogawa M, Sato S, Hasegawa F, Ino Y, Ono M, Hirohashi S. Actinin-4 increases cell motility and promotes lymph node metastasis of colorectal cancer. Gastroenterology, 128:51-62, 2005

32. Hara T, Honda K, Ono M, Naito K, Hirohashi S, Yamada T. Identification of 2 serum biomarkers of renal cell carcinoma by surface enhanced laser desorption/ionization mass spectrometry. J Urol, 174:1213-1217, 2005

33. Honda K, Hayashida Y, Umaki T, Okusaka T, Kosuge T, Kikuchi S, Endo M, Tsuchida A, Aoki T, Itoi T, Moriyasu F, Hirohashi S, Yamada T. Possible detection of pancreatic cancer by plasma protein profiling. Cancer Res, 65:10613-10622, 2005

34. Hayashida Y, Honda K, Osaka Y, Hara T, Umaki T, Tsuchida A, Aoki T, Hirohashi S, Yamada T. Possible prediction of chemoradiosensitivity of esophageal cancer by serum protein profiling. Clin Cancer Res, 11:8042-8047, 2005

4. Biology Division

35. Nakano T, Tani M, Nishioka M, Kohno T, Otsuka A, Ohwada S, Yokota J. Genetic and epigenetic alterations of the candidate tumor-suppressor gene MYO18B, on chromosome arm 22q, in colorectal cancer. Genes Chromosomes Cancer, 43:162-171, 2005

36. Kishimoto M, Kohno T, Okudela K, Otsuka A, Sasaki H, Tanabe C, Sakiyama T, Hirama C, Kitabayashi I, Minna JD, Takenoshita S, Yokota J. Mutations and deletions of the CBP gene in human lung cancer. Clin Cancer Res, 11:512-519, 2005

37. Sato M, Takahashi K, Nagayama K, Arai Y, Ito N, Okada M, Minna JD, Yokota J, Kohno T. Identification of chromosome arm 9p as the most frequent target of homozygous deletions in lung cancer. Genes Chromosomes Cancer, 44:405-414, 2005

38. Sakiyama T, Kohno T, Minami S, Ohta T, Yanagitani N, Sobue T, Kunitoh H, Saito R, Shimizu K, Hirama C, Kimura J, Maeno G, Hirose H, Eguchi T, Saito D, Ohki M, Yokota J. Association of amino acid substitution polymorphisms in DNA repair genes, TP53, POL1, REV1 and LIG4, with lung cancer risk. Int J Cancer, 114:730-737, 2005

39. Aoki M, Yamamura Y, Noshiro H, Sakai K, Yokota J, Kohno T, Tokino T, Ishida S, Ohyama S, Ninomiya I, Uesaka K, Kitajima M, Shimada S, Matsuno S, Yano M, Hiratsuka M, Sugimura H, Itoh F, Minamoto T, Maehara Y, Takenoshita S, Aikou T, Katai H, Yoshimura K, Takahashi T, Akagi K, Sairenji M, Yamamoto K, Sasazuki T. A full genome scan for gastric cancer. J Med Genet, 42:83-87, 2005

40. Ferreira P, Oliveira MJ, Beraldi E, Mateus AR, Nakajima T, Gleave M, Yokota J, Carneiro F, Huntsman D, Seruca R, Suriano G. Loss of functional E-cadherin renders cells more resistant to the apoptotic agent taxol in vitro. Exp Cell Res, 310:99-104, 2005

41. Sato M, Sasaki H, Kazui T, Yokota J, Kohno T. Probing the chromosome 9p21 region susceptible to DNA double-strand breaks in human cells in vivo by restriction enzyme transfer. Oncogene, 24:6108-6118, 2005

5. Pharmacology Division

42. Ota T, Takeda K, Akiba H, Hayakawa Y, Ogasawara K, Ikarashi Y, Miyake S, Wakasugi H, Yamamura T, Kronenberg M, Raulet DH, Kinoshita K, Yagita H, Smyth MJ, Okumura K. IFN-g-mediated negative feedback regulation of NKT-cell function by CD94/NKG2. Blood, 106:184-192, 2005

43. Nishikawa H, Kato T, Tawara I, Takemitsu T, Saito K, Wang L, Ikarashi Y, Wakasugi H, Nakayama T, Taniguchi M, Kuribayashi K, Old LJ, Shiku H. Accelerated chemically induced tumor development mediated by CD4+CD25+regulatory T cells in wild-type hosts. PNAS, 102:9253-9257, 2005

44. Ikarashi Y, Iizuka A, Koshidaka Y, Heike Y, Takaue Y, Yoshida M, Kronenberg M, Wakasugi H. Phenotypical and functional alterations during the expansion phase of invariant Va14 natural killer T (Va14i NKT) cells in mice primed with a-galactosylceramide. Immunology, 116:30-37, 2005

45. Hosokawa M, Kadota R, Shichijo S, Itoh K, Dmitriev I, Krasnykh V, Curiel DT, Takaue Y, Wakasugi H, Takashima S, Heike Y. Cell cycle arrest and apoptosis induced by SART-1 gene transduction. Anticancer Res, 25:1983-1990, 2005

46. Ikarashi Y, Iizuka A, Heike Y, Yoshida M, Takaue Y, Wakasugi H. Cytokine production and migration of in vitro-expanded NK1.1- invariant Va14 natural killer T (Va14i NKT) cells using a-galactosylceramide and IL-2. Immunol Lett, 101:160-167, 2005

47. Fujii H, Seki S, Kobayashi S, Kitada T, Kawakita N, Adachi K, Tsutsui H, Nakanishi K, Fujiwara H, Ikarashi Y, Taniguchi M, Mitchell K, Ikemoto M, Nakajima Y, Arakawa T, Kaneda K. A murine model of NKT cell-mediated liver injury induced by alpha-galactosylceramide/d-galactosamine. Virchows Arch, 446:663-673, 2005

48. Sakai K, Arao T, Shimoyama T, Murofushi K, Sekijima M, Kaji N, Tamura T, Saijo N, Nishio K. Dimerization and the signal transduction pathway of a small in-frame deletion in the epidermal growth factor receptor. FASEB J, 20:311-313, 2006. Epub 2005 Dec 22

49. Ando K, Ohmori T, Inoue F, Kadofuku T, Hosaka T, Ishida H, Shirai T, Okuda K, Hirose T, Horichi N, Nishio K, Saijo N, Adachi M, Kuroki T. Enhancement of sensitivity to tumor necrosis factor a in non-small cell lung cancer cells with acquired resistance to gefitinib. Clin Cancer Res, 11:8872-8879, 2005

50. Shimura M, Saito A, Matsuyama S, Sakuma T, Terui Y, Ueno K, Yumoto H, Yamauchi K, Yamamura K, Mimura H, Sano Y, Yabashi M, Tamasaku K, Nishio K, Nishino Y, Endo K, Hatake K, Mori Y, Ishizaka Y, Ishikawa T. Element array by scanning X-ray fluorescence microscopy after cis-diamminedichloro-platinum(II) treatment. Cancer Res, 65:4998-5002, 2005

51. Koizumi F, Shimoyama T, Taguchi F, Saijo N, Nishio K. Establishment of a human non-small cell lung cancer cell line resistant to gefitinib. Int J Cancer, 116:36-44, 2005

52. Kimura H, Kasahara K, Sekijima M, Tamura T, Nishio K. Plasma MIP-1b levels and skin toxicity in Japanese non-small cell lung cancer patients treated with the EGFR-targeted tyrosine kinase inhibitor, gefitinib. Lung Cancer, 50:393-399, 2005

53. Yamamoto N, Tamura T, Murakami H, Shimoyama T, Nokihara H, Ueda Y, Sekine I, Kunitoh H, Ohe Y, Kodama T, Shimizu M, Nishio K, Ishizuka N, Saijo N. Randomized pharmacokinetic and pharmacodynamic study of docetaxel: dosing based on body-surface area compared with individualized dosing based on cytochrome P450 activity estimated using a urinary metabolite of exogenous cortisol. J Clin Oncol, 23:1061-1069, 2005

54. Nishio K, Arao T, Shimoyama T, Fujiwara Y, Tamura T, Saijo N. Translational studies for target-based drugs. Cancer Chemother Pharmacol, 1:s90-s93, 2005

55. Korfee S, Eberhardt W, Fujiwara Y, Nishio K. The role of DNA-microarray in translational cancer research. Curr Pharmacogenomics, 3:201-216, 2005

56. Nishio M, Ohyanagi F, Horiike A, Ishikawa Y, Satoh Y, Okumura S, Nakagawa K, Nishio K, Horai T. Gefitinib treatment affects androgen levels in non-small-cell lung cancer patients. Br J Cancer, 92:1877-1880, 2005

6. Cancer Medicine and Biophysics Division

57. Arakawa H. p53, apoptosis and axon-guidance molecules. Cell Death Differ, 12:1057-1065, 2005

7. Growth Factor Division

58. Miyamoto Y, Chen L, Sato M, Sokabe M, Nabeshima T, Pawson T, Sakai R, Mori N. Hippocampal synaptic modulation by the phosphotyrosine adapter protein ShcC/N-Shc via interaction with the NMDA receptor. J Neurosci, 25:1826-1835, 2005

59. Osajima-Hakomori Y, Miyake I, Ohira M, Nakagawara A, Nakagawa A, Sakai R. Biological role of anaplastic lymphoma kinase in neuroblastoma. Am J Pathol, 167:213-222, 2005

60. Miyake I, Hakomori Y, Misu Y, Nakadate H, Matsuura N, Sakamoto M, Sakai R. Domain-specific function of ShcC docking protein in neuroblastoma cells. Oncogene, 24:3206-3215, 2005

61. Seo S, Asai T, Saito T, Suzuki T, Morishita Y, Nakamoto T, Ichikawa M, Yamamoto G, Kawazu M, Yamagata T, Sakai R, Mitani K, Ogawa S, Kurokawa M, Chiba S, Hirai H. Crk-associated substrate lymphocyte type is required for lymphocyte trafficking and marginal zone B cell maintenance. J Immunol, 175:3492-3501, 2005

62. Azuma K, Tanaka M, Uekita T, Inoue S, Yokota J, Ouchi Y, Sakai R. Tyrosine phosphorylation of paxillin affects the metastatic potential of human osteosarcoma. Oncogene, 24:4754-4764, 2005

63. Wang J, Kataoka H, Suzuki M, Sato N, Nakamura R, Tao H, Maruyama K, Isogaki J, Kanaoka S, Ihara M, Tanaka M, Kanamori M, Nakamura T, Shinmura K, Sugimura H. Downregulation of EphA7 by hypermethylation in colorectal cancer. Oncogene, 24:5637-5647, 2005

64. Nakamura R, Kataoka H, Sato N, Kanamori M, Ihara M, Igarashi H, Ravshanov S, Wang Y-J, Li Z-Y, Shimamura T, Kobayashi T, Konno H, Shinmura K, Tanaka M, Sugimura H. EPHA2/EFNA1 expression in human gastric cancer. Cancer Sci, 96:42-47, 2005

65. Tanaka M, Kamata R, Sakai R. EphA2 phosphorylates the cytoplasmic tail of claudin-4 and mediates paracellular permeability. J Biol Chem, 280:42375-42382, 2005

66. Tanaka M, Kamata R, Sakai R. Phosphorylation of ephrin-B1 via the interaction with claudin following cell-cell contact formation. EMBO J, 24:3700-3711, 2005

67. Anilkumar N, Uekita, T, Couchman JR, Nagase H, Seiki M, Itoh Y. Palmitoylation at Cys574 is essential for MT1-MMP to promote cell migration. FASEB J, 19:1326-1328, 2005

68. Hirao W, Gotoh I, Uekita T, Seiki M. Membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein -1(MTCBP-1) acts as an eukaryotic aci-reductone dioxygenase(ARD) in the methionine salvage pathway. Genes Cells, 10:565-574, 2005

8. Molecular Oncology Division

69. Nguyen LA, Pandolfi PP, Aikawa Y, Tagata Y, Ohki M, Kitabayashi I. Physical and functional link of the leukemia-associated factors AML1 and PML. Blood, 105:292-300, 2005

9. Virology Division

70. Kuroda M, Kiyono T, Oikawa K, Yoshida K, Mukai K. The human papillomavirus E6 and E7 inducible oncogene, hWAPL, exhibits potential as a therapeutic target. Br J Cancer, 92:290-293, 2005

71. Goto H, Kiyono T, Tomono Y, Kawajiri A, Urano T, Furukawa K, Nigg EA, Inagaki M. Complex formation of Plk1 and INCENP required for metaphase-anaphase transition. Nat Cell Biol, 8:180-187, 2006. Epub 2005 Dec 25

72. Maeda T, Tashiro H, Katabuchi H, Begum M, Ohtake H, Kiyono T, Okamura H. Establishment of an immortalised human ovarian surface epithelial cell line without chromosomal instability. Br J Cancer, 93:116-123, 2005

73. Mori T, Kiyono T, Imabayashi H, Takeda Y, Tsuchiya K, Miyoshi S, Makino H, Matsumoto K, Saito H, Ogawa S, Sakamoto M, Hata J, Umezawa A. Combination of hTERT and bmi-1, E6, or E7 induces prolongation of the life span of bone marrow stromal cells from an elderly donor without affecting their neurogenic potential. Mol Cell Biol, 25:5183-5195, 2005

74. Terai M, Uyama T, Sugiki T, Li X-K, Umezawa A, Kiyono T. Immortalization of human fetal cells: the life span of umbilical cord blood-derived cells can be prolonged without manipulating p16INK4a/RB braking pathway. Mol Biol Cell, 16:1491-1499, 2005

75. Saito M, Handa K, Kiyono T, Hattori S, Yokoi T, Tsubakimoto T, Harada H, Noguchi T, Toyoda M, Sato S, Teranaka T. Immortalization of cementoblast progenitor cells with Bmi-1 and TERT. J Bone Miner Res, 20:50-57, 2005

76. Fujita M. DNA replication initiation. In: D. R. Ganten, K. Delbruck, M. (ed.), Encyclopedic References of Genomics and Proteomics in Molecular Medicine. Heidelberg: Springer-Verlag, in press.

77. Daikoku T, Kudoh A, Fujita M, Sugaya Y, Isomura H, Shirata N, Tsurumi T. Architecture of replication compartments formed during Epstein-Barr virus lytic replication. J Virol, 79:3409-3418, 2005

78. Kudoh A, Fujita M, Zhang L, Shirata N, Daikoku T, Sugaya Y, Isomura H, Nishiyama Y, Tsurumi T. Epstein-Barr virus lytic replication elicits ATM checkpoint signal transduction while providing an S-phase-like cellular environment. J Biol Chem, 280:8156-8163, 2005

79. Shirata N, Kudoh A, Daikoku T, Tatsumi Y, Fujita M, Kiyono T, Sugaya Y, Isomura H, Ishizaki K, Tsurumi T. Activation of ataxia telangiectasia-mutated DNA damage checkpoint signal transduction elicited by herpes simplex virus infection. J Biol Chem, 280:30336-30341, 2005

80. Tsurumi T, Fujita M, Kudoh A. Latent and lytic Epstein-Barr virus replication strategies. Rev Med Virol, 15:3-15, 2005

10. Genetics Division

81. Nishigaki M, Aoyagi K, Danjoh I, Fukaya M, Yanagihara K, Sakamoto H, Yoshida T, Sasaki H. Discovery of aberrant expression of R-RAS by cancer-linked DNA hypomethylation in gastric cancer using microarrays. Cancer Res, 65:2115-2124, 2005

82. Morita E, Narikiyo M, Yokoyama A, Yano A, Kamoi K, Yoshikawa E, Yamaguchi T, Igaki H, Tachimori Y, Kato H, Saito D, Hanada N, Sasaki H. Predominant presence of Streptococcus anginosus in the saliva of alcoholics. Oral Microbiol Immunol, 20:362-365, 2005

83. Suzuki Y, Kagawa N, Fujino T, Sumiya T, Andoh T, Ishikawa K, Kimura R, Kemmochi K, Ohta T, Tanaka S. A novel high-throughput (HTP) cloning strategy for site-directed designed chimeragenesis and mutation using the Gateway cloning system. Nucleic Acids Res, 33:e109, 2005

84. Tachibana M, Ueda J, Fukuda M, Takeda N, Ohta T, Iwanari H, Sakihama T, Kodama T, Hamakubo T, Shinkai Y. Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9. Genes Dev, 19:815-826, 2005

85. Hichiya H, Tanaka-Kagawa T, Soyama A, Jinno H, Koyano S, Katori N, Matsushima E, Uchiyama S, Tokunaga H, Kimura H, Minami N, Katoh M, Sugai K, Goto Y, Tamura T, Yamamoto N, Ohe Y, Kunitoh H, Nokihara H, Yoshida T, Minami H, Saijo N, Ando M, Ozawa S, Saito Y, Sawada J. Functional characterization of five novel CYP2C8 variants, G171S, R186X, R186G, K247R, and K383N, found in a Japanese population. Drug Metab Dispos, 33:630-636, 2005

86. Koyano S, Saito Y, Sai K, Kurose K, Ozawa S, Nakajima T, Matsumoto K, Saito H, Shirao K, Yoshida T, Minami H, Ohtsu A, Saijo N, Sawada J. Novel genetic polymorphisms in the NR3C1 (glucocorticoid receptor) gene in a Japanese population. Drug Metab Pharmacokin, 20:79-84, 2005

87. Saeki M, Saito Y, Jinno H, Sai K, Hachisuka A, Kaniwa N, Ozawa S, Kawamoto M, Kamatani N, Shirao K, Minami H, Ohtsu A, Yoshida T, Saijo N, Komamura K, Kotake T, Morishita H, Kamakura S, Kitakaze M, Tomoike H, Sawada J. Genetic variations and haplotypes of UGT1A4 in a Japanese population. Drug Metab Pharmacokin, 20:144-151, 2005

88. Saeki M, Saito Y, Jinno H, Sai K, Kaniwa N, Ozawa S, Komamura K, Kotake T, Morishita H, Kamakura S, Kitakaze M, Tomoike H, Shirao K, Minami H, Ohtsu A, Yoshida T, Saijo N, Kamatani N, Sawada J. Genetic polymorphisms of UGT1A6 in a Japanese population. Drug Metab Pharmacokin, 20:85-90, 2005

89. Kubo T, Kim S-R, Sai K, Saito Y, Nakajima T, Matsumoto K, Saito H, Shirao K, Yamamoto N, Minami H, Ohtsu A, Yoshida T, Saijo N, Ohno Y, Ozawa S, Sawada J. Functional characterization of three naturally occurring single nucleotide polymorphisms in the CES2 gene encoding carboxylesterase 2 (HCE-2). Drug Metab Dispos, 33:1482-1487, 2005

90. Katoh Y, Katoh M. Identification and characterization of rat Dact1 and Dact2 genes in silico.Int J Mol Med, 15:1045-1049, 2005

91. Katoh M. WNT/PCP signaling pathway and human cancer (Review). Oncol Rep, 14:1583-1588, 2005

92. Katoh M, Katoh M. Comparative genomics on ROR1 and ROR2 orthologs. Oncol Rep, 14:1381-1384, 2005

93. Katoh Y, Katoh M. Comparative genomics on SLIT1, SLIT2, and SLIT3 orthologs. Oncol Rep, 14:1351-1355, 2005

94. Katoh Y, Katoh M. Comparative genomics on Sonic hedgehog orthologs. Oncol Rep, 14:1087-1090, 2005

95. Katoh M, Katoh M. Comparative genomics on FGF8, FGF17, and FGF18 orthologs. Int J Mol Med, 16:493-496, 2005

96. Katoh Y, Katoh M. Comparative genomics on SOX2 orthologs. Oncol Rep, 14:797-800, 2005

97. Katoh Y, Katoh M. Comparative genomics on mammalian Fgf6 - Fgf23 locus. Int J Mol Med, 16:355-358, 2005

98. Katoh Y, Katoh M. Comparative genomics on BMP4 orthologs. Int J Oncol, 27:581-585, 2005

99. Katoh Y, Katoh M. Comparative genomics on FGF11 orthologs. Oncol Rep, 14:291-294, 2005

100. Katoh M., Katoh M. Comparative genomics on mammalian FGF3 - FGF4 olocus. Int J Oncol, 27:281-285, 2005

101. Katoh M, Katoh M. Identification and characterization of TMEM16H gene in silico. Int J Mol Med, 15:353-358, 2005

102. Katoh Y, Katoh M. Identification and characterization of DISP3 gene in silico. Int J Oncol, 26:551-556, 2005

103. Katoh Y, Katoh M. Identification and characterization of rat Desert hedgehog and Indian hedgehoggenes in silico. Int J Oncol, 26:545-549, 2005

104. Katoh M, Katoh M. Characterization of KIF12 gene in silico. Oncol Rep, 13:367-370, 2005

105. Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schonbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y.; FANTOM Consortium; RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group). The transcriptional landscape of the mammalian genome. Science, 309:1559-1563, 2005

106. Swain RK, Katoh M, Medina A, Steinbeisser H. Xenopusfrizzled-4S, a splicing variant of Xfz4, is a context-dependent activator and inhibitor of Wnt/b-catenin signaling. Cell Commun Signal, 3:12, 2005

107. Katoh Y, Katoh M. Hedgehog signaling pathway and gastric cancer. Cancer Biol Ther, 4:1050-1054, 2005

108. Katoh Y, Katoh M. Comparative genomics on FGF16 orthologs. Int J Mol Med, 16:959-963, 2005

109. Katoh Y, Katoh M. Comparative genomics on FGF7, FGF10, FGF22 orthologs, and identification of fgf25. Int J Mol Med, 16:767-770, 2005

110. Katoh M, Katoh M. Comparative genomics on FGF20 orthologs. Oncol Rep, 14:287-290, 2005

111. Katoh M, Katoh M. Comparative genomics on SNAI1, SNAI2, and SNAI3 orthologs. Oncol Rep, 14:1083-1086, 2005

112. Katoh M. Epithelial-mesenchymal transition in gastric cancer (Review). Int J Oncol, 27:1677-1683, 2005

113. Katoh M. WNT2B. Comparative integromics and clinical application (Review). Int J Mol Med, 16:1103-1108, 2005

114. Katoh M. Molecular evolution of WNT2B orthologs. Int J Oncol, 26:1135-1139, 2005

115. Katoh Y, Katoh M. Comparative genomics on DKK2 and DKK4 orthologs. Int J Mol Med, 16:477-481, 2005

116. Katoh Y, Katoh M. Comparative genomics on SFRP1 orthologs. Int J Oncol, 27:861-865, 2005

117. Katoh M, Katoh M. Comparative genomics on SFRP2 orthologs. Oncol Rep, 14:783-787, 2005

118. Katoh Y, Katoh M. Comparative genomics on Shisa orthologs. Int J Mol Med, 16:181-185, 2005

119. Katoh Y, Katoh M. Comparative genomics on DKK1 orthologs. Int J Oncol, 27:275-279, 2005

120. Katoh M, Katoh M. Comparative genomics on FZD7 orthologs. Int J Mol Med, 15:1051-1055, 2005

121. Katoh M, Katoh M. Identification and characterization of rat Dact1 and Dact2 genes in silico. Int J Mol Med, 15:1045-1049, 2005

122. Katoh Y, Katoh M. Comparative genomics on nemo-like kinase gene. Int J Oncol, 26:1715-1719, 2005

123. Katoh Y, Katoh M. Comparative genomics on FZD8 orthologs. Oncol Rep, 13:993-997, 2005

124. Katoh Y, Katoh M. Comparative genomics on WNT9A orthologs. Oncol Rep, 13:989-992, 2005

125. Katoh Y, Katoh M. Comparative genomics on VANGL1 and VANGL2 genes. Int J Oncol, 26:1435-1440, 2005

126. Katoh M, Katoh M. Comparative genomics on Norrie disease gene. Int J Mol Med, 15:885-889, 2005

127. Katoh Y, Katoh M. Comparative genomics on WNT11 gene. Int J Mol Med, 15:879-883, 2005

128. Katoh M, Katoh M. Comparative genomics on WNT7A orthologs. Oncol Rep, 13:777-780, 2005

129. Katoh Y, Katoh M. Comparative genomics on WNT16 orthologs. Oncol Rep, 13:771-775, 2005

130. Katoh M, Katoh M. Comparative genomics on WNT5A and WNT5B genes. Int J Mol Med, 15:749-753, 2005

131. Katoh M. Comparative genomics on WNT3 - WNT9B gene cluster. Int J Mol Med, 15:743-747, 2005

132. Katoh M, Katoh M. Comparative genomics on WNT8A and WNT8B genes. Int J Oncol, 26:1129-1133, 2005

133. Katoh Y, Katoh M. Identification and characterization of rat Wnt1 and Wnt10b genes in silico. Int J Oncol, 26:841-845, 2005

134. Katoh Y, Katoh M. Identification and characterization of rat Bcl9l gene in silico. Int J Oncol, 26:835-840, 2005

135. Katoh M, Katoh M. Identification and characterization of rat Ror1 and Ror2 genes in silico. Int J Mol Med, 15:533-538, 2005

136. Katoh Y, Katoh M. Identification and characterization of rat Wnt6 and Wnt10a genes in silico. Int J Mol Med, 15:527-531, 2005

137. Katoh M, Katoh M. Identification and characterization of rat Ankrd6 gene in silico. Int J Mol Med, 15:359-363, 2005

138. Ishii H, Inageta T, Mimori K, Saito T, Sasaki H, Isobe M, Mori M, Croce CM, Huebner K, Ozawa K, Furukawa Y. Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis. PNAS, 102:9655-9660, 2005

139. Tsuyama N, Danjoh I, Otsuyama K, Obata M, Tahara H, Ohta T, Ishikawa H. IL-6-induced Bcl6 variant 2 supports IL-6-dependent myeloma cell proliferation and survival through STAT3. Biochem Biophys Res Commun, 337:201-208, 2005

140. Morikawa S, Sakiyama T, Hasegawa H, Saijo M, Maeda A, Kurane I, Maeno G, Kimura J, Hirama C, Yoshida T, Ozaki Y, Sata T, Kurata T, Kojima A. An attenuated LC16m8 smallpox vaccine: analysis of full-genome sequence and induction of immune protection. J Virol, 79:11873-11891, 2005

141. Kohda R, Othubo T, Kuwakado Y, Tanaka K, Kitahara T, Yoshimura K, Mimura M. Prospective studies on mental status and quality of life in patients with head and neck cancer treated by radiation. Psycho-oncology, 14:331-336, 2005

11. Radiobiology Division

142. Okamoto K, Kashima K, Pereg Y, Ishida M, Yamazaki S, Nota A, Teunisse A, Migliorini D, Kitabayashi I, Marine J-C, Prives C, Shiloh Y, Jochemsen AG, Taya Y. DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation. Mol Cell Biol, 25:9608-9620, 2005

143. Bae B-I, Xu H, Igarashi S, Fujimuro M, Agrawal N, Taya Y, Hayward DS, Moran TH, Montell C, Ross CA, Snyder SH, Sawa A. p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease. Neuron, 47:29-41, 2005

144. Merlo P, Fulco M, Costanzo A, Mangiacasale R, Strano S, Blandino G, Taya Y, Lavia P, Levrero M. A Role of p73 in Mitotic Exit. J Biol Chem, 280:30354-30360, 2005

145. Arima Y, Nitta M, Kuninaka S, Zhang D, Fujiwara T, Taya Y, Nakao M, Saya H. Transcriptional blockade induces p53-dependent apoptosis associated with translocation of p53 to mitochondria. J Biol Chem, 280:19166-19176, 2005

146. Takaki T, Fukasawa K, Suzuki-Takahashi I, Semba K, Kitagawa M, Taya Y, Hirai H. Preferences for phosphorylation sites in the retinoblastoma protein of D-type cyclin-dependent kinases, Cdk4 and Cdk6, in vitro. J Biochem, 137:381-386, 2005

12. Carcinogenesis Division

147. Ushijima T, Abe M. DNA methylation and carcinogenesis. In: Kuriyama S, Yoshiji H (eds), New Perspectives in Cancer Research and Therapy. India, Research Signpost, pp 1-11, 2005

148. Ushijima T. Detection and interpretation of altered methylation patterns in cancer cells. Nat Rev Cancer,5:223-231, 2005

149. Furuta J, Kaneda A, Umebayashi Y, Otsuka F, Sugimura T, Ushijima T. Silencing of the thrombomodulin gene in human malignant melanoma. Melanoma Res, 15:15-20, 2005

150. Miyamoto K, Ushijima T. Diagnostic and therapeutic applications of epigenetics. Jpn J Clin Oncol, 35:293-301, 2005

151. Abe M, Ohira M, Kaneda A, Yagi Y, Yamamoto S, Kitano Y, Takato T, Nakagawara A, Ushijima T. CpG island methylator phenotype is a strong determinant of poor prognosis in neuroblastomas. Cancer Res, 65:828-834, 2005

152. Miyamoto K, Fukutomi T, Akashi-Tanaka S, Hasegawa T, Asahara T, Sugimura T, Ushijima T. Identification of 20 genes aberrantly methylated in human breast cancers. Int J Cancer, 116:407-414, 2005

153. Ushijima T, Okochi-Takada E. Aberrant methylations in cancer cells: where do they come from? Cancer Sci, 96:206-211, 2005

154. Ushijima T, Watanabe N, Shimizu K, Miyamoto K, Sugimura T, Kaneda A. Decreased fidelity in replicating CpG methylation patterns in cancer cells. Cancer Res, 65:11-17, 2005

155. Niwa T, Yamashita S, Tsukamoto T, Kuramoto T, Nomoto T, Wakazono K, Fujita H, Matsushima T, Tatematsu M, Sugimura T, Ushijima T. Whole-genome analyses of loss of heterozygosity and methylation analysis of four tumor-suppressor genes in N-methyl-N'-nitro-N-nitrosoguanidine-induced rat stomach carcinomas. Cancer Sci, 96:409-413, 2005

156. Yamashita S, Suzuki S, Nomoto T, Kondo Y, Wakazono K, Tsujino Y, Sugimura T, Shirai T, Homma Y, Ushijima T. Linkage and microarray analyses of susceptibility genes in ACI/Seg rats: a model for prostate cancers in the aged. Cancer Res, 65:2610-2616, 2005

157. Yamashita S, Wakazono K, Nomoto T, Tsujino Y, Kuramoto T, Ushijima, T. Expression quantitative trait loci analysis of 13 genes in the rat prostate. Genet, 171:1231-1238, 2005

158. Kuramoto T, Morimura K, Nomoto T, Namiki C, Hamada S, Fukushima S, Sugimura T, Serikawa T, Ushijima T. Sparse and wavy hair: a new model for hypoplasia of hair follicle and mammary glands on rat chromosome 17. J Hered, 96:339-345, 2005

159. Tsukamoto T, Mizoshita T, Mihara M, Tanaka H, Takenaka Y, Yamamura Y, Nakamura S, Ushijima T, Tatematsu M. Sox2 expression in human stomach adenocarcinomas with gastric and gastric-and-intestinal-mixed phenotypes. Histopathology, 46:649-658, 2005

160. Chi X-Z, Yang J-O, Lee K-Y, Ito K, Sakakura C, Li Q-L, Kim H-R, Cha E-J, Lee Y-H, Kaneda A, Ushijima T, Kim W-J, Ito Y, Bae S-C. RUNX3 suppresses gastric epithelial cell growth by inducing p21WAF1/Cip1 expression in cooperation with transforming growth factor b-activated SMAD. Mol Cell Biol, 25:8097-8107, 2005

13. Section for Studies on Metastasis

161. Takeshita F, Minakuchi Y, Nagahara S, Honma K, Sasaki H, Hirai K, Teratani T, Namatame N, Yamamoto Y, Hanai K, Kato T, Sano A, Ochiya T. Efficient delivery of small interfering RNA to bone-metastatic tumors by usingatelocollagen in vivo. PNAS, 102:12177-12182, 2005

162. Saito S, Honma K, Kita-Matsuo H, Ochiya T, Kato K. Gene expression profiling of cerebellar development with high-throughput functional analysis. Physiol Genomics, 22:8-13, 2005

163. Teratani T, Yamamoto H, Aoyagi K, Sasaki H, Asari A, Quinn G, Sasaki H, Terada M, Ochiya T. Direct hepatic fate specification from mouse embryonic stem cells. Hapatology, 41:836-846, 2005

164. Yamamoto Y, Teratani T, Yamamoto H, Quinn G, Murata S, Ikeda R, Kinoshita K, Matsubara K, Kato T, Ochiya T. Recapitulation of in vivo gene expression during hepatic differentiation from murine embryonic stem cells. Hepatology, 42:558-567, 2005

165. Teratani T, Quinn G, Yamamoto Y, Sato T, Yamanokuchi H, Asari A, Ochiya T. Long-term maintenance of liver-specific functions in cultured ES cell-derived hepatocyte with hyaluronan sponge. Cell Transplant, 14: 629-635, 2005

14. Section for Studies on Host-Immune Response

166. Miura Y, Ohnami S, Yoshida K, Ohashi M, Nakano M, Ohnami S, Fukuhara M, Yanagi K, Matsushita A, Uchida E, Asaka M, Yoshida T, Aoki K. Intraperitoneal injection of adenovirus expressing antisense K-ras RNA suppresses peritoneal dissemination of hamster syngeneic pancreatic cancer without systemic toxicity. Cancer Lett, 218:53-62, 2005

167. Ohashi M, Yoshida K, Kushida M, Miura Y, Ohnami S, Ikarashi Y, Kitade Y, Yoshida T, Aoki K. Adenovirus-mediated interferon a gene transfer induces regional direct cytotoxicity and possible systemic immunity against pancreatic cancer. Br J Cancer, 93:441-449, 2005

15. ADP-ribosylation in Oncology Project

168. Masutani M, Gunji A, Tsutsumi M, Ogawa K, Kamada N, Shirai T, Jishage K, Nakagama H, Sugimura T. Role of poly-ADP-ribosylation in cancer development. In: Burkle A (ed), Poly(ADP-ribosyl)ation. Georgetown, Texas, USA, Eurekah. Com., pp 1-15, 2005

169. Shibata A, Kamada N, Masumura K, Nohmi T, Kobayashi S, Teraoka H, Nakagama H, Sugimura T, Suzuki H, Masutani M. Parp-1 deficiency causes an increase of deletion mutations and insertions/rearrangements in vivo after treatment with an alkylating agent. Oncogene, 24:1328-1337, 2005

170. Ariumi Y, Turelli P, Masutani M, Trono D. DNA damage sensors ATM, ATR, DNA-PKcs, and PARP-1 are dispensable for human immunodeficiency virus type 1 integration. J Virol, 79:2973-2978, 2005

171. Masutani M, Nakagama H, Sugimura T. Poly(ADP-ribosyl)ation in relation to cancer and autoimmune disease. Cell Mol Life Sci, 62:769-783, 2005

172. Shiokawa M, Masutani M, Fujihara H, Ueki K, Nishikawa R, Sugimura T, Kubo H, Nakagama H. Genetic alteration of poly(ADP-ribose) polymerase-1 in human germ cell tumors. Jpn J Clin Oncol, 35:97-102, 2005

16. Cancer Genomics Project

173. Katoh H, Shibata T, Kokubu A, Ojima H, Loukopoulos P, Kanai Y, Kosuge T, Fukayama M, Kondo T, Sakamoto M, Hosoda F, Ohki M, Imoto I, Inazawa J, Hirohashi S. Genetic profile of hepatocellular carcinoma revealed by array-based comparative genomic hybridization: identification of genetic indicators to predict patient outcome. J Hepatol, 43:863-874, 2005

174. Peng W-X, Shibata T, Katoh H, Kokubu A, Matsuno Y, Asamura H, Tsuchiya R, Kanai Y, Hosoda F, Sakiyama T, Ohki M, Imoto I, Inazawa J, Hirohashi S. Array-based comparative genomic hybridization analysis of high-grade neuroendocrine tumors of the lung. Cancer Sci, 96:661-667, 2005

175. Shibata T, Uryu S, Kokubu A, Hosoda F, Ohki M, Sakiyama T, Matsuno Y, Tsuchiya R, Kanai Y, Kondo T, Imoto I, Inazawa J, Hirohashi S. Genetic classification of lung adenocarcinoma based on array-based comparative genomic hybridization analysis: its association with clinicopathologic features. Clin Cancer Res, 11:6177-6185, 2005

176. Yoshida Y, Shibata T, Kokubu A, Tsuta K, Matsuno Y, Kanai Y, Asamura H, Tsuchiya R, Hirohashi S. Mutations of the epidermal growth factor receptor gene in atypical adenomatous hyperplasia and bronchioloalveolar carcinoma of the lung. Lung Cancer, 50:1-8, 2005

17. Cancer Prevention Basic Research Project

177. Totsuka Y, Nishigaki R, Enomoto S, Takamura-Enya T, Masumura K, Nohmi T, Kawahara N, Sugimura T, Wakabayashi K. Structures and biological properties of DNA adducts derived from N-nitroso bile acid conjugates. Chem Res Toxicol, 18:1553-1562, 2005

178. Takamura-Enya T, Mano N, Kawahara N, Goto J, Wakabayashi K. Formation of DNA adducts with cholyl adenylate, a putative intermediate for biosynthesis of cholyl-CoA. Chem Res Toxicol, 18:1715-1720, 2005

179. Watanabe T, Hasei T, Takahashi T, Asanoma M, Murahashi T, Hirayama T, Wakabayashi K. Detection of a novel mutagen, 3,6-dinitrobenzo[e]pyrene, as a major contaminant in surface soil in Osaka and Aichi prefectures, Japan. Chem Res Toxicol, 18:283-289, 2005

180. Iidaka T, Tsukamoto T, Totsuka Y, Hirata A, Sakai H, Shirai N, Yamamoto M, Wakabayashi K, Yanai T, Masegi T, Donehower LA, Tatematsu M. Lack of elevated liver carcinogenicity of aminophenylnorharman in p53-deficient mice. Cancer Lett, 217:149-159, 2005

181. Kashiwabara S, Kashimoto N, Uesaka T, Wakabayashi K, Kamiya K, Watanabe H. Tumor induction by azoxymethane (AOM) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in F344 rat gastric mucosa featuring intestinal metaplasia caused by X-irradiation. J Exp Clin Cancer Res, 24:305-312, 2005

182. Kawamori T, Kitamura T, Watanabe K, Uchiya N, Maruyama T, Narumia S, Sugimura T, Wakabayashi K. Prostaglandin E receptor subtype EP1 deficiency inhibits colon cancer development. Carcinogenesis, 26:353-357, 2005

183. Niho N, Mutoh M, Kitamura T, Takahashi M, Sato H, Yamamoto H, Maruyama T, Ohuchida S, Sugimura T, Wakabayashi K. Suppression of azoxymethane-induced colon cancer development in rats by a prostaglandin E receptor EP1-selective antagonist. Cancer Sci, 96:260-264, 2005

184. Shoji Y, Takahashi M, Takasuka N, Niho N, Kitamura T, Sato H, Maruyama T, Sugimoto Y, Narumiya S, Sugimura T, Wakabayashi K. Prostaglandin E receptor EP3 deficiency modifies tumor outcome in mouse two-stage skin carcinogenesis. Carcinogenesis, 26:2116-2122, 2005

185. Tanaka T, Suzuki R, Kohno H, Sugie S, Takahashi M, Wakabayashi K. Colonic adenocarcinomas rapidly induced by the combined treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate in male ICR mice possess b-catenin gene mutations and increases immunoreactivity for b-catenin, cyclooxygenase-2 and inducible nitric oxide synthase. Carcinogenesis, 26:229-238, 2005

186. Niho N, Mutoh M, Takahashi M, Tsutsumi K, Sugimura T, Wakabayashi K. Concurrent suppression of hyperlipidemia and intestinal polyp formation by NO-1886, increasing lipoprotein lipase activity in Min mice. Proc Natl Acad Sci USA, 102: 2970-2974, 2005

187. Tsuda H, Fukamachi K, Ohshima Y, Ueda S, Matsuoka Y, Hamaguchi T, Ohnishi T, Takasuka N, Naito A. High susceptibility of human c-Ha-ras proto-oncogene transgenic rats to carcinogenesis: a cancer-prone animal model. Cancer Sci, 96:309-316, 2005

188. Iigo M, Shimamura M, Hirano S, Nabeshima K, Ohkubo S, Tamura Y, Tsuda H. Cancer prevention and anti-metastatic effect by oral administration of bovine lactoferrin. In: Tanaka T, Tsuda H (eds), Carcinogenesis and Modification of Carcinogenesis. India, Research Signpost, pp 229-242, 2005

189. Sugie S, Ohnishi M, Ushida J, Yamamoto T, Hara A, Koide A, Mori Y, Kohno H, Suzuki R, Tanaka T, Wakabayashi K, Mori H. Effect of a-naphthyl isothiocyanate on 2-amino-3-methylimidazo[4,5-b]pyridine (PhIP)-induced mammary carcinogenesis in rats. Int J Cancer, 115:346-350, 2005

190. Kawamori T, Wakabayashi K. Prostanoid receptors and colon carcinogenesis. In: Tanaka T, Tsuda H (eds), Carcinogenesis and Modification of Carcinogenesis. India, Res Signpost, pp243-251, 2005

191. Shiotani B, Watanabe M, Totsuka Y, Sugimura T, Wakabayashi K. Involvement of nucleotide excision repair (NER) system in repair of mono ADP-ribosylated dG adducts produced by pierisin-1, a cytotoxic protein from cabbage butterfly. Mutat Res, 572:150-155, 2005

18. Cancer Transcriptome Project

192. Zou J, Ichikawa H, Blackburn ML, Hu HM, Zielinska-Kwiatkowska A, Mei Q, Roth GJ, Chansky HA, Yang L. The oncogenic TLS-ERG fusion protein exerts different effects in hematopoietic cells and fibroblasts. Mol Cell Biol, 25:6235-6246, 2005

19. Proteome Bioinformatics Project

193. Seike M, Kondo T, Fujii K, Okano T, Yamada T, Matsuno Y, Gemma A, Kudoh S, Hirohashi S. Proteomic signatures for histological types of lung cancer. Proteomics, 5:2939-2948, 2005

194. Fujii K, Kondo T, Yokoo H, Yamada T, Matsuno Y, Iwatsuki K, Hirohashi S. Protein expression pattern distinguishes different lymphoid neoplasms. Proteomics, 5:4274-4286, 2005

195. Fujii K, Kondo T, Yokoo H, Yamada T, Iwatsuki K, Hirohashi S. Proteomic study of human hepatocellular carcinoma using two-dimensional difference gel electrophoresis with saturation cysteine dye. Proteomcis, 5:1411-1422, 2005

196. Mori Y, Kondo T, Yamada T, Tsuchida A, Aoki T, Hirohashi S. Two-dimensional electrophoresis database of fluorescence-labeled proteins of colon cancer cells. J Chromatogr B, 823:82-97, 2005

20. Tumor Endocrinology Project

197. Kagaya S, Hashida R, Ohkura N, Tsukada T, Sugita Y, Terakawa M, Tsujimoto G, Katsunuma T, Akasawa A, Matsumoto K, Saito H. NR4A orphan nuclear receptor family in peripheral blood eosinophils from patients with atopic dermatitis and apoptotic eosinophils in vitro. Int Arch Allergy Immunol, 137 Suppl 1:35-44, 2005

198. Kagaya S, Ohkura N, Tsukada T, Miyagawa M, Sugita Y, Tsujimoto G, Matsumoto K, Saito H, Hashida R. Prostaglandin A2 acts as a transactivator for NOR1 (NR4A3) within the nuclear receptor superfamily. Biol Pharm Bull, 28:1603-1607, 2005

199. Ohkura N, Takahashi M, Yaguchi H, Nagamura Y, Tsukada T. Coactivator-associated arginine methyltransferase 1, CARM1, affects pre-mRNA splicing in an isoform-specific manner. J Biol Chem, 280:28927-28935, 2005

21. Tumor Suppression and Functional Genomics Project

200. Goto A, Niki T, Chi-pin L, Matsubara D, Murakami Y, Funata N, Fukayama M. Loss of TSLC expression in lung adencarcinoma: relationships with histological subtypes, gender, and prognostic significance. Cancer Sci, 96:480-486, 2005

201. Kikuchi S, Yamada D, Fukami T, Masuda M, Sakurai-Yageta M, Williams YN, Maruyama T, Asamura H, Matsuno Y, Onizuka M, Murakami Y. Promoter methylation of DAL-1/4.1B predicts poor prognosis in non-small cell lung cancer. Clin Cancer Res, 11:2954-2961, 2005

202. Masuda M, Kikuchi S, Maruyama T, Sakurai-Yageta M, Williams YN, Ghosh HP, Murakami Y. TSLC (tumor suppressor in lung cancer)1 suppresses epithelial cell scattering and tubulogenesis. J Biol Chem, 280:42164-42171, 2005

203. Sussan TE, Pletcher MT, Murakami Y, Reever RH. Tumor suppressor in lung cancer 1 (TSLC1) alters tumorigenic growth properties and gene expression. Mol Cancer, 4:28, 2005

204. Sasaki H, Nishikata I, Shiraga T, Akamatsu E, Ishida Y, Fukami T, Hidaka T, Kubuki Y, Okayama A, Hamada K, Okabe H, Murakami Y, Tsubouchi H, Morishita K. Overexpression of a cell adhesion molecule, TSLC1, as a possible molecular marker for acute type of adult T-cell leukemia. Blood, 105:1204-1213, 2005

205. Murakami Y. Involvement of a cell adhesion molecule, TSLC1/IGSF4, in human oncogenesis. Cancer Sci, 96:543-552, 2005

206. Mototani H, Mabuchi A, Saito S, Fujioka M, Iida A, Takatori Y, Kotani A, Kubo T, Nakamura K, Sekine A, Murakami Y, Tsunoda T, Notoya K, Nakamura Y, Ikegawa S. A functional single nucleotide polymorphism in the core promoter region of CALM1 is associated with hip osteoarthritis in Japanese. Hum Mol Genet, 14:1009-1017, 2005

207. Kuroki K, Tsuchiya N, Shiroishi M, Rasubala L, Yamashita Y, Matsuta K, Fukuzawa T, Kusaoi M, Murakami Y, Takiguchi M, Juji T, Hashimoto H, Kohda D, Maenaka K, Tokunaga K. Extensive polymorphisms of LILRB1 (ILT2, LIR1) and their association with HLA-DRB1 shared epitope negative rheumatoid arthritis. Hum Mol Genet, 14:2469-2480, 2005

22. Pathology Division, East

208. Ishii G, Sangai T, Sugiyama K, Ito T, Hasebe T, Endoh Y, Magae J, Ochiai A. In vivo characterization of bone marrow-derive fibroblasts recruited into fibrotic lesions. Stem Cells, 23: 699-706, 2005

209. Ishii G, Sangai T, Ito T, Hasebe T, Endoh Y, Sasaki H, Harigaya K, Ochiai A. In vivo and in vitro characterization of human fibroblasts recruited selectively into human cancer stroma. Int J Cancer, 117:212-220, 2005

210. Sangai T, Ishii G, Kodama K, Miyamoto S, Aoyagi Y, Ito T, Magae J, Sasaki H, Nagashima T, Miyazaki M, Ochiai A. Effect of differences in cancer cells and tumor growth sites on recruiting bone marrow-derived endothelial cells and myofibroblasts in cancer-induced stroma. Int J Cancer, 115:885-892, 2005

211. Hasebe T, Sasaki S, Imoto S, Wada N, Ishii G, Ochiai A. Primary tumour- vessel tumour- nodal tumour classification for patients with invasive ductal carcinoma of the breast. Br J Cancer, 92: 847-856, 2005

212. Hasebe T, Konishi M, Iwasaki M, Endoh Y, Nakagohri T, Takahashi S, Kinosihta T, Ochiai A. Histological characteristics of tumor cells and stomal cells in vessels and lymph nodes are important prognostic parameters of extrahepatic bile duct carcinoma: a prospective study. Hum Pathol, 36: 655-664, 2005

213. Miyamoto S, Nakamura M, Shitara K, Nakamura K, Ohki Y, Ishii G, Goya M, Kodama K, Sangai T, Maeda H, Zhang S-C, Chiba T, Ochiai A. Blockade of paracrine supply of insulin- like growth factors using neutralizing antibodies suppresses the liver metastasis of human colorectal cancers. Clin Cancer Res, 11:3494-3502, 2005

214. Shiono S, Ishii G, Nagai K, Yoshida J, Nishimura M, Murata Y, Tsuta K, Nishiwaki Y, Kodama T, Ochiai A. Histopathological prognositic factors in resected colorectal lung metastases. Ann Thorac Surg 79: 278-282, 2005

215. Hishida T, Yoshida J, Nishimura M, Ishii G, Nishiwaki Y, Nagai K. Multiple sclerosing hemangiomas with a 10-year history. Jpn J Clin Oncol, 35:37-39, 2005

216. Kobayashi Y, Yokose T, Kawamura K, Iwasaki S, Murata S, Onuma S, Hasebe T, Nagai K, Sasaki S, Ochiai A. Cytologic factors associated with prognosis in patients with peripheral adenocarcinoma of the lung measuring 3 cm or less in greatest dimension. Cancer, 105:44-51, 2005

217. Kanomata N, Yokose T, Kamijo T, Yonou H, Hasebe T, Itano N, Kimata K, Ochiai A. Hyaluronan synthase expression in pleural malignant mesothelioma. Virchows Arch, 446:246-250, 2005

218. Kanomata N, Nakahara R, Oda T, Aoyagi Y, Ishii G, Yokose T, Hasebe T, Nagai K, Yokozaki H, Ochiai A. Expression and localization of mRNAs for matrix metalloproteinases and their inhibitors in mixed bronchioloalveolar carcinomas with invasive components. Mod Pathol, 18:828-837, 2005

219. Nakamura M, Miyamoto S, Maeda H, Ishii G, Hasebe T, Chiba T, Asaka M, Ochiai A. Matrix metalloproteinase-7 degrades all insulin-like growth factor binding proteins and facliltates insulin-like growth factor bioavailability. Biochem Biophys Res Commun, 333:1011-1016, 2005

220. Kodama K, Ishii G, Miyamoto S, Goya M, Zhang SC, Sangai T, Yoshikawa T, Hasebe T, Hitomi Y, Izumi K, Ochiai A. Liminin 5 expression protects against anoikis at spread and lepidic growth of human lung adenocracinoma. Int. J. Cancer, 116: 876-884, 2005

221. Shiono S, Ishii G, Nagai K, Yoshida J, Nishimura M, Murata Y, Tsuta K, Kim YH, Nishiwaki Y, Kodama T, Iwasaki M, Ochiai A. Predictive factors for local recurrence of resected colorectal lung metastases. Ann thorac Surg, 80:1040-1045, 2005

222. Sano Y, Maeda N, Kanzaki A, Fujii T, Ochiai A, Takenoshita S, Takebayashi Y. Angiogenesis in colon hyperplastic polyp. Cancer Lett, 218: 223-228, 2005

223. Yano T, Sano Y, Iwasaki J, Fu KI, Yoshino T, Kato S, Mera K, Ochiai A, Fujii T, Yoshida S. Distribution and prevalence of colorectal hyperplastic polyps using magnifying pan-mucosal chromoendoscopy and its relationship with synchronous colorectal cancer: Prospective study. J Gastroenterol Hepatol, 20:1572-1577, 2005

224. Nagashima F, Boku N, Ohtsu A, Yoshida S, Hasebe T, Ochiai A, Satake Y, Saito H, Miyata Y, Hyodo I, Ando M. Biological markers as a predictor for response and prognosis of unresectable gastric cancer patients treated with irinotecan and cisplatin. Jpn J Clin Oncol, 35: 714-719, 2005

225. Mitsunaga S, Hasebe T, Iwasaki M, Kinoshita T, Ochiai A, Shimizu N. Important pregnostic histological parameters for patients with invasive ductal carcinoma of the pancreas. Cancer Sci, 96: 858-865, 2005

226. Shimizu K, Yoshida J, Nagai K, Nishimura M, Ishii G, Morishita Y, Nishiwaki Y. Visceral pleural invasion is an invasive and aggressive indicator of non-small cell lung cancer. J Thorac Cardiovasc Surg, 130: 160-165, 2005

227. Takamochi K, Yoshida J, Murakami K, Niho S, Ishii G, Nishimura M, Nishiwaki Y, Suzuki K, Nagai K. Pitfalls in lymph node staging with postiron emission tomography in non-small cell lung cancer patients. Lung Cancer, 47: 235-242, 2005

228. Tsuta K, Ishii G, Kim E, Shiono S. Nishiwaki Y, Endoh Y, Kodama T, Nishiwaki K, Ochiai A. Primary lung adenocarcinoma with massive lymphocyte infiltration. Am J Clin Pathol, 123:547-552, 2005

229. Takahashi Y, Kondo K, Hirose T, Nakagawa H, Tsuyuguchi M, Hashimoto M, Sano T, Ochiai A, Monden Y. Microsatellite instability and protein expression of the DNA mismatch repair gene, hMLH1, of lung cancer in chromate-exposed workers. Mol Carcinog, 42:150-158, 2005

230. Kobayashi A, Hasebe T, Endo Y, Sasaki S, Konishi M, Sugito M, Kinoshita T, Saito N, Ochiai A. Primary gastric choriocarcinoma: two case reports and a pooled analysis of 53 cases. Gastric Cancer, 8:178-185, 2005

231. Shimizu K, Ishii G, Nagai K, Yokose T, Ishizawa K, Tamaru J, Yoshida J, Nishimura M, Ochiai A. Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT Lymphoma) in the thymus: Report of four cases. Jpn J Clin Oncol, 35: 412-416, 2005

23. Investigative Treatment Division

232. Bae Y, Nishiyama N, Fukushima S, Koyama H, Matsumura Y, Kataoka K. Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy. Bioconjug Chem, 16:122-130, 2005

233. Hamaguchi T, Matsumura Y, Suzuki M, Shimizu K, Goda R, Nakamura I, Nakatomi I, Yokoyama M, Kataoka K, Kakizoe T. NK105, a paclitaxel-incorporating micellar nanoparticle formulation, can extend in vivo antitumour activity and reduce the neurotoxicity of paclitaxel. Br J Cancer, 92:1240-1246, 2005

234. Uchino H, Matsumura Y, Negishi T, Koizumi F, Hayashi T, Honda T, Nishiyama N, Kataoka K, Naito S, Kakizoe T. Cisplatin-incorporating polymeric micelles (NC-6004) can reduce nephrotoxicity and neurotoxicity of cisplatin in rats. Br J Cancer, 93:678-687, 2005

235. Matsushita H, Matsumura Y, Moriya Y, Akasu T, Fujita S, Yamamoto S, Onouchi S, Saito N, Sugito M, Ito M, Kozu T, Minowa T, Nomura S, Tsunoda H, Kakizoe T. A new methodology for isolating colonocytes from naturally evacuated feces and its clinical application to colorectal cancer diagnosis. Gastroenterology, 129:1918-1927, 2005

236. Suzuki A, Iida S, Kato-Uranishi M, Tajima E, Zhan F, Hanamura I, Huang Y, Ogura T, Takahashi S, Ueda R, Barlogie B, Shaughnessy J Jr, Esumi H. ARK5 is transcriptionally regulated by the Large-MAF family and mediates IGF-1-induced cell invasion in multiple myeloma: ARK5 as a new molecular determinant of malignant multiple myeloma. Oncogene, 24:6936-6944, 2005

237. Suzuki A, Kusakai G, Shimojo Y, Chen J, Ogura T, Kobayashi M, Esumi H. Involvement of transforming growth factor-b1 signaling in hypoxia-induced tolerance to glucose starvation. J Biol Chem, 280:31557-31563, 2005

238. Lu J, Imamura K, Nomura S, Mafune K, Nakajima A, Kadowaki T, Kubota N, Terauchi Y, Ishii G, Ochiai A, Esumi H, Kaminishi M. Chemopreventive effect of peroxisome proliferator-activated receptor g on gastric carcinogenesis in mice. Cancer Res, 65:4769-4774, 2005

239. Muto M, Katada C, Sano Y, Yoshida S. Narrow band imaging: A new diagnostic approach to visualize angiogenesis in the superficial neoplasia. Clin Gastroenterol Hepatol, 3 (Suppl):S16-S20, 2005

240. Muto M, Ugumori T, Sano Y, Ohtsu A, Yoshida S. Narrow band imaging combined with magnified endoscopy for the cancer at the head and neck region. Dig Endosc, 17 (Suppl):S23-S24, 2005

241. Sano Y, Muto M, Tajiri H, Ohtsu A, Yoshida S. Optical/digital chromoendoscopy during colonoscopy using narrow-band imaging system. Dig Endosc, 17 (Suppl):S43-S48, 2005

242. Yano T, Muto M, Minashi K, Ohtsu A, Yoshida S. Photodynamic therapy as salvage treatment for local failures after definitive chemoradiotherapy for esophageal cancer. Gastrointest Endosc, 62:31-36, 2005

243. Muto M, Takahashi M, Ohtsu A, Ebihara S, Yoshida S, Esumi H. Risk of multiple squamous cell carcinomas both in the esophagus and the head and neck region. Carcinogenesis, 26:1008-1012, 2005

244. Katada C, Muto M, Manabe T, Ohtsu A, Yoshida S. Local recurrence of squamous-cell carcinoma of the esophagus after EMR. Gastrointest Endosc, 61:219-225, 2005

245. Muto M, Miyamoto S, Hosokawa A, Doi T, Ohtsu A, Yoshida S, Endo Y, Hosokawa K, Saito D, Shim CS, Gossner L. Endoscopic mucosal resection in the stomach using the insulated-tip needle-knife. Endoscopy, 37:178-182, 2005

24. Psycho-Oncology Division

246. Akizuki N, Yamawaki S, Akechi T, Nakano T, Uchitomi Y. Development of an Impact Thermometer for use in combination with the Distress Thermometer as a brief screening tool for adjustment disorders and/or major depression in cancer patients. J Pain Symptom Manage, 29:91-99, 2005

247. Shimizu K, Akechi T, Okamura M, Oba A, Fujimori M, Akizuki N, Uchitomi Y. Usefulness of the nurse-assisted screening and psychiatric referral program. Cancer, 103:1949-1956, 2005

248. Kobayakawa M, Yamawaki S, Hamazaki K, Akechi T, Inagaki M, Uchitomi Y. Levels of omega-3 fatty acid in serum phospholipids and depression in patients with lung cancer. Br J Cancer, 93:1329-1333, 2005

249. Fujimori M, Akechi T, Akizuki N, Okamura M, Oba A, Sakano Y, Uchitomi Y. Good communication with patients receiving bad news about cancer in Japan. Psycho-Oncology, 14:1043-1051, 2005

250. Yoshikawa E, Matsuoka Y, Inagaki M, Nakano T, Akechi T, Kobayakawa M, Fujimori M, Nakaya N, Akizuki N, Imoto S, Murakami K, Uchitomi Y. No adverse effects of adjuvant chemotherapy on hippocampal volume in Japanese breast cancer survivors. Breast Cancer Res Treat, 92:81-84, 2005

251. Morita T, Akechi T, Ikenaga M, Kizawa Y, Kohara H, Mukaiyama T, Nakaho T, Nakashima N, Shima Y, Matsubara T, Uchitomi Y. Late referrals to specialized palliative care service in Japan. J Clin Oncol, 23:2637-2644, 2005

252. Morita T, Hyodo I, Yoshimi T, Ikenaga M, Tamura Y, Yoshizawa A, Shimada A, Akechi T, Miyashita M, Adachi I, Japan Palliative Oncology Study Group. Association between hydration volume and symptoms in terminally ill cancer patients with abdominal malignancies. Ann Oncol, 16:640-647, 2005

253. Matsuoka Y, Inagaki M, Sugawara Y, Imoto S, Akechi T, Uchitomi Y. Biomedical and psychosocial determinants of intrusive recollections in breast cancer survivors. Psychosomatics, 46:203-211, 2005

254. Morita T, Takigawa C, Onishi H, Tajima T, Tani K, Matsubara T, Miyoshi I, Ikenaga M, Akechi T, Uchitomi Y, for the Japan Pain R, Palliative Medicine, and Psycho-Oncology (PRPP) Study Group. Opioid rotation from morphine to fentanyl in delirious cancer patients: an open-label trial. J Pain Symptom Manage, 30:96-103, 2005

255. Okamura M, Yamawaki S, Akechi T, Taniguchi K, Uchitomi Y. Psychiatric disorders following first breast cancer recurrence: prevalence, associated factors and relationship to quality of life. Jpn J Clin Oncol, 35:302-309, 2005

256. Sugawara Y, Akechi T, Okuyama T, Matsuoka Y, Nakano T, Inagaki M, Imoto S, Fujimori M, Hosaka T, Uchitomi Y. Occurrence of fatigue and associated factors in disease-free breast cancer patients without depression. Support Care Cancer, 13:628-636, 2005

257. Fukui T, Takahashi O, Rahman M, Iino K, Uchitomi Y, Ogawa S, Kita M, Kimijima I, Kondo H, Shino M, Takumi Y, Tsuneto A, Hamaguchi K, Matsumoto M, Mukaiyama T, Yamamuro M, Watanabe A, Setoyama O, Hiraga K. Clinical effectiveness of evidence-based guidelines for pain management of terminal cancer patients in Japan. JMAJ, 48:216-223, 2005

258. Morita T, Chinone Y, Ikenaga M, Miyoshi M, Nakaho T, Nishitateno K, Sakonji M, Shima Y, Suenaga K, Takigawa C, Kohara H, Tani K, Kawamura Y, Tatsuhiro M, Watanabe A, Yagi Y, Sasaki T, Higuchi A, Kimura H, Abo H, Ozawa T, Kizawa Y, Uchitomi Y, Japan Pain PM, Rehabilitation, and Psycho-Oncology Study Group. Efficacy and safety of palliative sedation therapy: a multicenter, prospective, observational study conducted on specialized palliative care units in Japan. J Pain Symptom Manage, 30:320-328, 2005

259. Morita T, Chinone Y, Ikenaga M, Miyoshi M, Nakaho T, Nishitateno K, Sakonji M, Shima Y, Suenaga K, Takigawa C, Kohara H, Tani K, Kawamura Y, Tatsuhiro M, Watanabe A, Yagi Y, Sasaki T, Higuchi A, Kimura H, Abo H, Ozawa T, Kizawa Y, Uchitomi Y, Japan Pain PM, Rehabilitation, and Psycho-Oncology Study Group. Ethical validity of palliative sedation therapy: a multicenter, prospective, observational study conducted on specialized palliative care units in Japan. J Pain Symptom Manage, 30:308-319, 2005

260. Nakaya N, Tsubono Y, Kuriyama S, Hozawa A, Shimazu T, Kurashima K, Fukudo S, Shibuya D, Tsuji I. Alcohol consumption and the risk of cancer in Japanese men; the Miyagi cohort study. Eur J Cancer Prev, 14:169-174, 2005

261. Morita T, Bito S, Kurihara Y, Uchitomi Y. Development of a clinical guideline for palliative sedation therapy using the Delphi method. J Palliat Med, 8:716-729, 2005

262. Kumano H, Hasebe E, Fujimoto H, Matsuoka N, Yoshiuchi K, Uchitomi Y, Akechi T, Nakano T, Kobayashi M, Agari I, Kuboki T. Harmony seeking and the risk of prostate cancer: a prebioptic study. J Psychosom Res, 59:167-174, 2005

263. Nakaya N, Fukudo S, Akizuki N, Yoshikawa E, Kobayakawa M, Fujimori M, Shimizu K, Nagai K, Nishiwaki Y, Uchitomi Y. Twenty-four-hour urinary cortisol levels before complete resection of non-small cell lung cancer and survival. Acta Oncol, 44:399-405, 2005

264. Nakaya N, Tsubono Y, Nishino Y, Hosokawa T, Fukudo S, Shibuya D, Akizuki N, Yoshikawa E, Kobayakawa M, Fujimori M, Saito-Nakaya K, Uchitomi Y, Tsuji I. Personality and cancer survival: the Miyagi cohort study. Br J Cancer, 92:2089-2094, 2005

25. Epidemiology and Prevention Division

265. Inoue M, Yoshimi I, Sobue T, Tsugane S, JPHC Study Group. Influence of coffee drinking on subsequent risk of hepatocellular carcinoma: a prospective study in Japan. J Natl Cancer Inst, 97:293-300, 2005

266. Hanaoka T, Yamamoto S, Sobue T, Sasaki S, Tsugane S, the Japan Public Health Center-Based Prospective Study on Cancer and Cardiovascular Disease Study Group. Active and passive smoking and breast cancer risk in middle-aged Japanese women. Int J Cancer, 114:317-322, 2005

267. Inoue M, Tsugane S, the JPHC Study Group. Impact of alcohol drinking on total cancer risk: data from a large-scale population-based cohort study in Japan. Br J Cancer, 92:182-187, 2005

268. Kim MK, Sasaki S, Otani T, Tsugane S, for the Japan Public Health Center-based Prospective Study Group. Dietary patterns and subsequent colorectal cancer risk by subsite: a prospective cohort study. Int J Cancer, 115:790-798, 2005

269. Liu Y, Inoue M, Sobue T, Tsugane S, the JPHC Study Group. Reproductive factors, hormone use and the risk of lung cancer among middle-aged never-smoking Japanese women: a large-scale population-based cohort study. Int J Cancer, 117:662-666, 2005

270. Tsubono Y, Otani T, Kobayashi M, Yamamoto S, Sobue T, Tsugane S. No association between fruit or vegetable consumption and the risk of colorectal cancer in Japan. Br J Cancer, 92:1782-1784, 2005

271. Otani T, Iwasaki M, Inoue M, Tsugane S. Body mass index, body height and subsequent risk of colorectal cancer in middle-aged and elderly Japanese men and women: Japan Public Health Center-based Prospective Study. Cancer Causes Control, 16:839-850, 2005

272. Waki K, Noda M, Sasaki S, Matsumura Y, Takahashi Y, Isogawa A, Ohashi Y, Kadowaki T, Tsugane S, the JPHC Study Group. Alcohol consumption and other risk factors for self-reported diabetes among middle-aged Japanese: a population-based prospective study in the JPHC study cohort I. Diabet Med, 22:323-331, 2005

273. Iwasaki M, Akechi T, Uchitomi Y, Tsugane S, the Japan Public Health Center-based Prospective Study on Cancer and Cardiovascular Disease (JPHC study) Group. Cigarette smoking and completed suicide among middle-aged men: a population-based cohort study in Japan. Ann Epidemiol, 15:286-292, 2005

274. Ishihara J, Yamamoto S, Iso H, Inoue M, Tsugane S, the JPHC FFQ Validation Study Group. Validity of a self-administered food frequency questionnaire (FFQ) and its generalizability to the estimation of dietary folate intake in Japan. Nutr J, 4:1-10, 2005

275. Inoue M, Tsuji I, Wakai K, Nagata C, Mizoue T, Tanaka K, Tsugane S, Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan. Evaluation based on systematic review of epidemiological evidence among Japanese populations: tobacco smoking and total cancer risk. Jpn J Clin Oncol, 35:404-411, 2005

276. Tsugane S. Salt, salted food intake, and risk of gastric cancer: epidemiologic evidence. Cancer Sci, 96:1-6, 2005

277. Inoue M, Tsugane S. Epidemiology of gastric cancer in Japan. Postgrad Med J, 81:419-424, 2005

278. Tsukino H, Hanaoka T, Sasaki H, Motoyama H, Hiroshima M, Tanaka T, Kabuto M, Niskar AS, Rubin C, Patterson DG Jr, Turner W, Needham L, Tsugane S. Associations between serum levels of selected organochlorine compounds and endometriosis in infertile Japanese women. Environ Res, 99:118-125, 2005

279. Tsuchiya M, Katoh T, Motoyama H, Sasaki H, Tsugane S, Ikenoue T. Analysis of the AhR, ARNT, and AhRR gene polymorphisms: genetic contribution to endometriosis susceptibility and severity. Fertil Steril, 84:454-458, 2005

280. Tsuchiya M, Nakao H, Katoh T, Sasaki H, Hiroshima M, Tanaka T, Matsunaga T, Hanaoka T, Tsugane S, Ikenoue T. Association between endometriosis and genetic polymorphisms of the estradiol-synthesizing enzyme genes HSD17B1 and CYP19. Hum Reprod, 20:974-978, 2005

281. Otani T, Iwasaki M, Hanaoka T, Kobayashi M, Ishihara J, Natsukawa S, Shaura K, Koizumi Y, Kasuga Y, Yoshimura K, Yoshida T, Tsugane S. Folate, vitamin B6, vitamin B12, and vitamin B2 intake, genetic polymorphisms of related enzymes, and risk of colorectal cancer in a hospital-based case-control study in Japan. Nutr Cancer, 53:42-50, 2005

282. Liu Y, Yoshimura K, Hanaoka T, Ohnami S, Ohnami S, Kohno T, Yoshida T, Sakamoto H, Sobue T, Tsugane S. Association of habitual smoking and drinking with single nucleotide polymorphism (SNP) in 40 candidate genes: data from random population-based Japanese samples. J Hum Genet, 50:62-68, 2005

283. Kobayashi M, Hanaoka T, Hashimoto H, Tsugane S. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) level in human hair as biomarkers for dietary grilled/stir-fried meat and fish intake. Mutat Res, 588:136-142, 2005

284. Kawai A, Umeda T, Wada T, Ihara K, Isu K, Abe S, Ishii T, Sugiura H, Araki N, Ozaki T, Yabe H, Hasegawa T, Tsugane S, Beppu Y; JMOG Group. Alternating sequential chemotherapy with high-dose ifosfamide and doxorubicin/cyclophosphamide for adult non-small round cell soft tissue sarcomas. J Orthop Sci, 10:258-263, 2005

285. Hayashi R, Iwasaki M, Otani T, Wang N, Miyazaki H, Yoshiaki S, Aoki S, Koyama H, Suzuki S. Body mass index and mortality in a middle-aged Japanese cohort. J Epidemiol, 15:70-77, 2005

286. Wang N, Iwasaki M, Otani T, Hayashi R, Miyazaki H, Xiao L, Sasazawa Y, Suzuki S, Koyama H, Sakamaki T. Perceived health as related to income, socio-economic status, lifestyle, and social support factors in a middle-aged Japanese. J Epidemiol, 15:155-162, 2005

287. Ikeda S, Kurose K, Jinno H, Sai K, Ozawa S, Hasegawa R, Komamura K, Kotake T, Morishita H, Kamakura S, Kitakaze M, Tomoike H, Tamura T, Yamamoto N, Kunitoh H, Yamada Y, Ohe Y, Shimada Y, Shirao K, Kubota K, Minami H, Ohtsu A, Yoshida T, Saijo N, Saito Y, Sawada J. Functional analysis of four naturally occurring variants of human constitutive androstane receptor. Mol Genet Metab, 86:314-319, 2005

26. Statistics and Cancer Control Division

288. Marugame T, Yoshimi I, Kamo K, Imamura Y, Kaneko S, Mizuno S, Sobue T. Trends in lung cancer mortality among young adults in Japan. Jpn J Clin Oncol, 35:177-80, 2005

289. Marugame T, Kamo KI, Sobue T, Akiba S, Mizuno S, Satoh H, Suzuki T, Tajima K, Tamakoshi A, Tsugane S. Trends in smoking by birth cohorts born between 1900 and 1977 in Japan. Prev Med, 42:120-127, 2006. Epub 2005 Nov 3

290. Marugame T, Sobue T, Satoh H, Komatsu S, Nishino Y, Nakatsuka H, Nakayama T, Suzuki T, Takezaki T, Tajima K, Tominaga S. Lung cancer death rates by smoking status: comparison of the Three-Prefecture Cohort study in Japan to the Cancer Prevention Study II in the USA. Cancer Sci, 96:120-126, 2005

291. Kawamura T, Sobue T. Comparison of breast cancer mortality in five countries: France, Italy, Japan, the UK and the USA from the WHO Mortality Database (1960-2000). Jpn J Clin Oncol, 12:758-759, 2005

292. Marugame T, Mizuno S. Comparison of prostate cancer mortality in five countries: France, Italy, Japan, UK and USA from the WHO Mortality Database (1960-2000). Jpn J Clin Oncol, 11:690-691, 2005

293. Sano H, Hamashima C. Comparison of laryngeal cancer mortality in five countries: France, Italy, Japan, UK and USA from the WHO mortality database (1960-2000). Jpn J Clin Oncol, 10:626-629, 2005

294. Qiu D, Kaneko S. Comparison of esophageal cancer mortality in five countries: France, Italy, Japan, UK and USA from the WHO mortality database (1960-2000). Jpn J Clin Oncol, 9:564-567, 2005

295. Tanaka S, Sobue T. Comparison of oral and pharyngeal cancer mortality in five countries: France, Italy, Japan, UK and USA from the WHO Mortality Database (1960-2000). Jpn J Clin Oncol, 8:488-491, 2005

296. Imamura Y, Mizuno S. Comparison of leukemia mortality in five countries: France, Italy, Japan, UK and USA from the WHO Mortality Database (1960-2000). Jpn J Clin Oncol, 7:420-423, 2005

297. Marugame T, Kaneko S. Comparison of bladder cancer mortality in five countries: France, Italy, Japan, UK and USA from the WHO Mortality Database (1960-2000). Jpn J Clin Oncol, 6:357-360, 2005

298. Imamura Y, Mizuno S. Comparison of pancreatic cancer mortality in five countries: France, Italy, Japan, UK and USA from WHO mortality database (1960-2000). Jpn J Clin Oncol, 5:283-286, 2005

299. Yoshimi I, Kaneko S. Comparison of cancer mortality (rectal cancer) in five countries: France, Italy, Japan, UK and USA from WHO mortality database (1960-2000). Jpn J Clin Oncol, 4:224-227, 2005

300. Marugame T, Yoshimi I. Comparison of cancer mortality (lung cancer) in five countries: France, Italy, Japan, UK and USA from the WHO Mortality Database (1960-2000). Jpn J Clin Oncol, 3:168-170, 2005

301. Imamura Y, Yoshimi I. Comparison of cancer mortality (stomach cancer) in five countries: France, Italy, Japan, UK and USA from the WHO Mortality Database (1960-2000). Jpn J Clin Oncol, 2:103-105, 2005

302. Yoshimi I, Kaneko S. Comparison of cancer mortality (all malignant neoplasms) in five countries: France, Italy, Japan, UK and USA from the WHO Mortality Database (1960-2000). Jpn J Clin Oncol, 1:48-51, 2005

303. Kitano S, Inomata M, Sato A, Yoshimura K, Moriya Y, Study JCOG. Randomized controlled trial to evaluate laparoscopic surgery for colorectal cancer: Japan Clinical Oncology Group Study JCOG 0404. Jpn J Clin Oncol, 35:475-477, 2005

304. Atagi S, Kawahara M, Tamura T, Noda K, Watanabe K, Yokoyama A, Sugiura T, Senba H, Ishikura S, Ikeda H, Ishizuka N, Saijo N. Standard thoracic radiotherapy with or without concurrent daily low-dose carboplatin in elderly patients with locally advanced non-small cell lung cancer: a phase III trial of the Japan Clinical Oncology Group (JCOG9812). Jpn J Clin Oncol, 35:195-201, 2005

305. Kodera Y, Sasako M, Yamamoto S, Sano T, Nashimoto A, Kurita A; Gastric Cancer Surgery Study Group of Japan Clinical Oncology Group. Identification of risk factors for the development of complications following extended and superextended lymphadenectomies for gastric cancer. Br J Surg, 92:1103-1109, 2005

306. Horstmann E, McCabe MS, Grochow L, Yamamoto S, Rubinstein L, Budd T, Shoemaker D, Emanuel EJ, Grady C. Risks and benefits of phase 1 oncology trials, 1991 through 2002. N Engl J Med, 352:895-904, 2005

307. Ishikura S, Tobinai K, Ohtsu A, Nakamura S, Yoshino T, Oda I, Takagi T, Mera K, Kagami Y, Itoh K, Tamaki Y, Suzumiya J, Taniwaki M, Yamamoto S. Related Articles, Japanese multicenter phase II study of CHOP followed by radiotherapy in stage I-II, diffuse large B-cell lymphoma of the stomach. Cancer Sci, 96:349-52, 2005

Central Animal Laboratory

308. Murai M, Toyota M, Suzuki H, Satoh A, Sasaki Y, Akino K, Ueno M, Takahashi F, Kusano M, Mita H, Yanagihara K, Endo T, Hinoda Y, Tokino T, Imai K. Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer. Clin Cancer Res, 11:1021-1027, 2005

309. Yanagihara K, Takigahira M, Tanaka H, Komatsu T, Fukumoto H, Koizumi F, Nishio K, Ochiya T, Ino Y, Hirohashi S. Development and biological analysis of peritoneal metastasis mouse models for human scirrhous stomach cancer. Cancer Sci, 96:323-332, 2005