1. Pathology Division

1.  Arai E, Kanai Y, Ushijima S, Fujimoto H, Mukai K, Hirohashi S. Regional DNA hypermethylation and DNA methyltransferase (DNMT) 1 protein overexpression in both renal tumors and corresponding nontumorous renal tissues. Int J Cancer, 119:288-296, 2006

2.  Peng D-F, Kanai Y, Sawada M, Ushijima S, Hiraoka N, Kitazawa S, Hirohashi S. DNA methylation of multiple tumor-related genes in association with overexpression of DNA methyltransferase 1 (DNMT1) during multistage carcinogenesis of the pancreas. Carcinogenesis, 27:1160-1168, 2006

3.  Takada H, Imoto I, Tsuda H, Nakanishi Y, Sakakura C, Mitsufuji S, Hirohashi S, Inazawa J. Genomic loss and epigenetic silencing of very-low-density lipoprotein receptor involved in gastric carcinogenesis. Oncogene, 25:6554-6562, 2006

4.  Hiraoka N, Onozato K, Kosuge T, Hirohashi S. Prevalence of FOXP3⁺ regulatory T cells increases during the progression of pancreatic ductal adenocarcinoma and its premalignant lesions. Clin Cancer Res, 12:5423-5434, 2006

5.  Batistatou A, Charalabopoulos AK, Scopa CD, Nakanishi Y, Kappas A, Hirohashi S, Agnantis NJ, Charalabopoulos K. Expression patterns of dysadherin and E-cadherin in lymph node metastases of colorectal carcinoma. Virchows Arch, 448:763-767, 2006

6.  Kyzas PA, Stefanou D, Batistatou A, Agnantis NJ, Nakanishi Y, Hirohashi S, Charalabopoulos K. Dysadherin expression in head and neck squamous cell carcinoma: association with lymphangiogenesis and prognostic significance. Am J Surg Pathol, 30:185-193, 2006

7.  Izumi T, Oda Y, Hasegawa T, Nakanishi Y, Iwasaki H, Sonobe H, Goto H, Kusakabe H, Takahira T, Kobayashi C, Kawaguchi K, Saito T, Yamamoto H, Tamiya S, Iwamoto Y, Tsuneyoshi M. Prognostic significance of dysadherin expression in epithelioid sarcoma and its diagnostic utility in distinguishing epithelioid sarcoma from malignant rhabdoid tumor. Mod Pathol, 19:820-831, 2006

8.  Takahashi Y, Hiraoka N, Onozato K, Shibata T, Kosuge T, Nimura Y, Kanai Y, Hirohashi S. Solid-pseudopapillary neoplasms of the pancreas in men and women: do they differ? Virchows Arch, 448:561-569, 2006

9.  Eguchi T, Nakanishi Y, Shimoda T, Iwasaki M, Igaki H, Tachimori Y, Kato H, Yamaguchi H, Saito D, Umemura S. Histopathological criteria for additional treatment after endoscopic mucosal resection for esophageal cancer: analysis of 464 surgically resected cases. Mod Pathol, 19:475-480, 2006

10.  Maeshima AM, Maeshima A, Asamura H, Matsuno Y. Histologic prognostic factors for small-sized squamous cell carcinomas of the peripheral lung. Lung Cancer, 52:53-58, 2006

11.  Hata H, Hiraoka N, Ojima H, Shimada K, Kosuge T, Shimoda T. Carcinoid tumor arising in a duplication cyst of the duodenum. Pathol Int, 56:272-278, 2006

12.  Hibi T, Sakamoto Y, Tochigi N, Ojima H, Shimada K, Sano T, Kosuge T. Extended right hemihepatectomy as a salvage operation for recurrent bile duct cancer 3 years after pancreatoduodenectomy. Jpn J Clin Oncol, 36:176-179, 2006

13.  Nishizawa A, Nakanishi Y, Sasajima Y, Yamazaki N, Yamamoto A. Muir-torre syndrome with intriguing squamous lesions: a case report and review of the literature. Am J Dermatopathol, 28:56-59, 2006

14.  Yamaguchi Y, Hasegawa T, Sakurai S, Sakuma Y, Takazawa Y, Hishima T, Mitsuhashi T, Sekine S, Chuman H, Shimoda T. Interobserver variability in histologic recognition, interpretation of KIT immunostaining, and determining MIB-1 labeling indices in gastrointestinal stromal tumors and other spindle cell tumors of the gastrointestinal tract. Appl Immunohistochem Mol Morphol, 14:46-51, 2006

15.  Hibi T, Ojima H, Sakamoto Y, Kosuge T, Shimada K, Sano T, Sakamoto M, Kitajima M, Yamasaki S. A solid pseudopapillary tumor arising from the greater omentum followed by multiple metastases with increasing malignant potential. J Gastroenterol, 41:276-281, 2006

16.  Huang J-F, Takayasu K, Okada S, Shimada K, Nakanishi Y, Ikeda M. Primary hepatocellular carcinoma detected long after tumor markers and lymph node metastases-beyond our vision? Dig Dis Sci, 51:610-615, 2006

17.  Sakamoto Y, Sano T, Shimada K, Kosuge T, Kimata Y, Sakuraba M, Yamamoto J, Ojima H. Clinical significance of reconstruction of the right hepatic artery for biliary malignancy. Langenbecks Arch Surg, 391:203-208, 2006

18.  Itatsu K, Sano T, Hiraoka N, Ojima H, Takahashi Y, Sakamoto Y, Shimada K, Kosuge T. Intraductal tubular carcinoma in an adenoma of the main pancreatic duct of the pancreas head. J Gastroenterol, 41:702-705, 2006

19.  Maeda T, Tateishi U, Fujimoto H, Kanai Y, Sugimura K, Arai Y. Leiomyosarcoma of the renal vein: arterial encasement on contrast-enhanced dynamic computed tomography. Int J Urol, 13:611-612, 2006

20.  Nishizawa A, Nakanishi Y, Sasajima Y, Yamazaki N, Yamamoto A. Syringoid eccrine carcinoma with apparently aggressive transformation: case report and review of the literature. Int J Dermatol, 45:1218-1221, 2006

21.  Hotta K, Shimoda T, Nakanishi Y, Saito D. Usefulness of Ki-67 for predicting the metastatic potential of rectal carcinoids. Pathol Int, 56:591-596, 2006

22.  Shimada K, Sakamoto Y, Sano T, Kosuge T, Hiraoka N. Reappraisal of the clinical significance of tumor size in patients with pancreatic ductal carcinoma. Pancreas, 33:233-239, 2006

23.  Takahashi Y, Sakamoto Y, Shimada K, Sano T, Kosuge T, Onaya H, Mizuguchi Y, Hiraoka N. Imaging features of large intraductal papillary mucinous carcinoma of the pancreatic tail. Pancreas, 32:334-335, 2006

24.  Shimada K, Sakamoto Y, Sano T, Kosuge T, Hiraoka N. Invasive carcinoma originating in an intraductal papillary mucinous neoplasm of the pancreas: a clinicopathologic comparison with a common type of invasive ductal carcinoma. Pancreas, 32:281-287, 2006

25.  Nakagawa T, Hiraoka N, Ihara F, Komiyama M, Kanai Y, Matsuno Y. Primary adenocarcinoma of the rete testis with preceding diagnosis of pulmonary metastases. Int J Urol, 13:1532-1535, 2006

26.  Nakanishi Y. Histopathological features of the esophagogastric junction. Esophagus, 3:139-143, 2006

2. Biochemistry Division

27.  Suzuki R, Kohno H, Sugie S, Nakagama H, Tanaka T. Strain differences in the susceptibility to azoxymethane and dextran sodium sulfate-induced colon carcinogenesis in mice. Carcinogenesis, 27:162-169, 2006

28.  Osawa E, Nakajima A, Fujisawa T, Kawamura Y, Toyama-Sorimachi N, Nakagama H, Dohi T. Predominant T helper type 2-inflammatory responses promote murine colon cancers. Int J Cancer, 118:2232-2236, 2006

29.  Takahashi H, Masuda T, Schaefer K, Saubermann LJ, Fujisawa N, Fujisawa T, Fujita N, Yoneda M, Ikeda I, Shimamura T, Saito S, Tachibana M, Wada K, Nakagama H, Kadowaki T, Nakajima A. Inhibition of PPARg activity in esophageal carcinoma cells results in a drastic decrease of adhesive and invasive properties followed by an induction of apoptotic cell death. Cancer Sci, 97:854-860, 2006

30.  Uchida S, Kubo A, Kizu R, Nakagama H, Matsunaga T, Ishizaka Y, Yamashita K. Amino acids C-terminal to the 14-3-3 binding motif in CDC25B affect the efficiency of 14-3-3 binding. J Biochem, 139:761-769, 2006

31.  Nakagama H, Higuchi K, Tanaka E, Tsuchiya N, Nakashima K, Katahira M, Fukuda H. Molecular mechanisms for maintenance of G-rich short tandem repeats capable of adopting G4 DNA structures. Mutat Res, 598:120-131, 2006

3. Chemotherapy Division and Cancer Proteomics Project

32.  Ono M, Shitashige M, Honda K, Isobe T, Kuwabara H, Matsuzuki H, Hirohashi S, Yamada T. Label-free quantitative proteomics using large peptide data sets generated by nanoflow liquid chromatography and mass spectrometry. Mol Cell Proteomics, 5:1338-1347, 2006

4. Biology Division

33.  Matsumoto S, Iwakawa R, Kohno T, Suzuki K, Matsuno Y, Yamamoto S, Noguchi M, Shimizu E, Yokota J. Frequent EGFR mutations in noninvasive bronchioloalveolar carcinoma. Int J Cancer, 118:2498-2504, 2006

34.  Matsumoto S, Takahashi K, Iwakawa R, Matsuno Y, Nakanishi Y, Kohno T, Shimizu E, Yokota J. Frequent EGFR mutations in brain metastases of lung adenocarcinoma. Int J Cancer, 119:1491-1494, 2006

35.  Akca H, Tani M, Hishida T, Matsumoto S, Yokota J. Activation of the AKT and STAT3 pathways and prolonged survival by a mutant EGFR in human lung cancer cells. Lung Cancer, 54:25-33, 2006

36.  Inoue T, Kon T, Ajima R, Ohkura R, Tani M, Yokota J, Sutoh K. MYO18B interacts with the proteasomal subunit Sug1 and is degraded by the ubiquitin-proteasome pathway. Biochem Biophys Res Commun, 342:829-834, 2006

37.  Takahashi K, Kohno T, Ajima R, Sasaki H, Minna JD, Fujiwara T, Tanaka N, Yokota J. Homozygous deletion and reduced expression of the DOCK8 gene in human lung cancer. Int J Oncol, 28:321-328, 2006

38.  Nakamura N, Kobayashi K, Nakamoto M, Kohno T, Sasaki H, Matsuno Y, Yokota J. Identification of tumor markers and differentiation markers for molecular diagnosis of lung adenocarcinoma. Oncogene, 25:4245-4255, 2006

39.  Yanaihara N, Caplen N, Bowman E, Seike M, Kumamoto K, Yi M, Stephens RM, Okamoto A, Yokota J, Tanaka T, Calin GA, Liu C-G, Croce CM, Harris CC. Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell, 9:189-198, 2006

40.  Kohno T, Sakiyama T, Kunitoh H, Goto K, Nishiwaki Y, Saito D, Hirose H, Eguchi T, Yanagitani N, Saito, R, Sasaki-Matsumura R, Mimaki S, Toyama K, Yamamoto S, Kuchiba A, Sobue T, Ohta T, Ohki M, Yokota J. Association of polymorphisms in the MTH1 gene with small cell lung carcinoma risk. Carcinogenesis, 27:2448-2454, 2006

41.  Kohno T, Kunitoh H, Toyama K, Yamamoto S, Kuchiba A, Saito D, Yanagitani N, Ishihara S, Saito R, Yokota J. Association of the OGG1-Ser326Cys polymorphism with lung adenocarcinoma risk. Cancer Sci, 97:724-728, 2006

42.  Raimondi S, Paracchini V, Autrup H, Barros-Dios JM, Benhamou S, Boffetta P, Cote ML, Dialyna IA, Dolzan V, Filiberti R, Garte S, Hirvonen A, Husgafvel-Pursiainen K, Imyanitov EN, Kalina I, Kang D, Kiyohara C, Kohno T, Kremers P, Lan Q, London S, Povey AC, Rannug A, Reszka E, Risch A, Romkes M, Schneider J, Seow A, Shields PG, Sobti RC, Sorensen M, Spinola M, Spitz MR, Strange RC, Stucker I, Sugimura H, To-Figueras J, Tokudome S, Yang P, Yuan J-M, Warholm M, Taioli E. Meta- and pooled analysis of GSTT1 and Lung Cancer: a HuGE-GSEC review. Am J Epidemiol, 164:1027-1042, 2006

43.  Sasaki S, Sato M, Katsura Y, Kurimasa A, Chen DJ, Takeda S, Kuwano H, Yokota J, Kohno T. Rapid assessment of two major repair activities against DNA double-strand breaks in vertebrate cells. Biochem Biophys Res Commun, 339:583-590, 2006

44.  Kohno T, Yokota J. Molecular processes of chromosome 9p21 deletions causing inactivation of the p16 tumor suppressor gene in human cancer: Deduction from structural analysis of breakpoints for deletions. DNA Repair (Amst), 5:1273-1281, 2006

5. Pharmacology Division

45.  Imataki O, Heike Y, Ishida T, Takaue Y, Ikarashi Y, Yoshida M, Wakasugi H, Kakizoe T. Efficient ex vivo expansion of Va24⁺ NKT cells derived from G-CSF-mobilized blood cells. J Immunother, 29:320-327, 2006

46.  Kuwatani M, Ikarashi Y, Iizuka A, Kawakami C, Quinn G, Heike Y, Yoshida M, Asaka M, Takaue Y, Wakasugi H. Modulation of acute graft-versus-host disease and chimerism after adoptive transfer of in vitro-expanded invariant Va14 natural killer T cells. Immunol Lett, 106:82-90, 2006

47.  Kuwatani M, Ikarashi Y, Mineishi S, Asaka M, Wakasugi H. An irradiation-free nonmyeloablative bone marrow transplantation model: importance of the balance between donor T-cell number and the intensity of conditioning. Transplantation, 80:1145-1152, 2005

48.  Arao T, Yanagihara K, Takigahira M, Takeda M, Koizumi F, Shiratori Y, Nishio K. ZD6474 inhibits tumor growth and intraperitoneal dissemination in a highly metastatic orthotopic gastric cancer model. Int J Cancer, 118:483-489, 2006

49.  Sakai K, Arao T, Shimoyama T, Murofushi K, Sekijima M, Kaji N, Tamura T, Saijo N, Nishio K. Dimerization and the signal transduction pathway of a small in-grame deletion in the epidermal growth factor receptor. FASEB J, 20:311-313, 2006.

50.  Shimoyama T, Koizumi F, Fukumoto H, Kiura K, Tanimoto M, Saijo N, Nishio K. Effects of different combinations of gefitinib and irinotecan in lung cancer cell lines expressing wild or deletional EGFR. Lung Cancer, 53:13-21, 2006

51.  Sakai K, Yokote H, Murakami-Murofushi K, Tamura T, Saijo N, Nishio K. In-flame deletion in the EGF receptor alters kinase inhibition by gefitinib. Biochem J, 397:537-543, 2006

52.  Sekine I, Minna JD, Nishio K, Tamura T, Saijo N. A literature review of molecular markers predictive of clinical response to cytotoxic chemotherapy in patients with lung cancer. Int Thoracic Oncol, 1:31-37, 2006

53.  Yamanaka R, Arao T, Yajima N, Homma J, Genkai N, Sano M, Sekijima M, Nishio K. Identification of expressed genes characterizing long-term survival in malignant glioma patients. Oncogene, 25:5994-6002, 2006

54.  Kimura H, Fujiwara Y, Sone T, Kunitoh H, Tamura T, Kasahara K, Nishio K. High sensitivity detection of epidermal growth factor receptor mutations in the pleural effusion of non-small cell lung cancer patients. Cancer Sci, 97:642-648, 2006

55.  Park S, Shimizu C, Shimoyama T, Takeda M, Kinoshita T, Kohno T, Katsumata N, Kang YK, Nishio K, Fujiwara Y. Gene expression profiling of ATP binding cassette (ABC) transporters as a predictor of the pathologic response to neoadjuvant chemotherapy in breast cancer patients. Breast Cancer Res Treat, 99:9-17, 2006

56.  Shimoyama T, Hamano T, Natsume T, Koizumi F, Kiura K, Tanimoto M, Nishio K. Reference profiling of the genomic response induced by an anti-microtubule agent, TZT-1027 (Soblidotin), in vitro. Pharmacogenomics J, 6:388-396, 2006

57.  Kato T, Nishio K. Clinical aspects of epidermal growth factor receptor inhibitors: Benefit and risk. Respirology, 11:693-698, 2006

58.  Kimura H, Kasahara K, Shibata K, Sone T, Yoshimoto A, Kita K, Ichikawa Y, Waseda Y, Watanabe K, Shirasaki H, Ishiura Y, Mizuguchi M, Nakatsumi Y, Kashii T, Kobayashi M, Kunitoh H, Tamura T, Nishio K, Fujimura M, Nakao S. EGFR mutation of tumor and serum in the gefitinib treated patients with chemotherapy-naive non-small cell lung cancer. J Thorac Oncol, 1:260-267, 2006

59.  Kimura H, Kasahara K, Kawaishi M, Kunitoh H, Tamura T, Holloway B, Nishio K. Detection of epidermal growth factor receptor mutations in serum as a predictor of the response to gefitinib in patients with non-small lung cancer. Clin Cancer Res, 12:3915-3921, 2006

60.  Nishio M, Taguchi F, Ohyanagi F, Horiike A, Ishikawa Y, Satoh Y, Okumura S, Nakagawa K, Nishio K, Horai T. Gefitinib efficacy associated with multiple expression of HER family in non-small cell lung cancer. Anticancer Res, 26:3761-3765, 2006

61.  Nishio K, Arao T, Kato T, Yokote H. EGFR mutation in various tissues. Cancer Chemother Pharmacol, 58:s39-s41, 2006

62.  Kimura H, Fujiwara Y, Sone T, Kunitoh H, Tamura T, Kasahara K, Nishio K. EGFR mutation status in tumor-derived DNA from pleural effusion fluid is a practical basis for predicting response to gefitinib. Br J Cancer, 95:1390-1395, 2006

6. Cancer Medicine and Biophysics Division

63.  Masuda Y, Futamura M, Kamino H, Nakamura Y, Kitamura N, Ohnishi S, Miyamoto Y, Ichikawa H, Ohta T, Ohki M, Kiyono T, Egami H, Baba H, Arakawa H. The potential role of DFNA5, a hearing impairment gene, in p53-mediated cellular response to DNA damage. J Hum Genet, 51:652-664, 2006

64.  Nakamura Y, Futamura M, Kamino H, Yoshida K, Nakamura Y, Arakawa H. Identification of p53-46F as a super p53 with an enhanced ability to induce p53-dependent apoptosis. Cancer Sci, 97:633-641, 2006

7. Growth Factor Division

65.  Huang J, Sakai R, Furuichi T. The docking protein Cas links tyrosine phosphorylation signaling to elongation of cerebellar granule cell axons. Mol Biol Cell, 17:3187-3196, 2006

66.  Sawada Y, Tamada M, Dubrin-Thaler B, Cherniavskaya O, Sakai R, Tanaka S, Sheetz MP. Force sensing by mechanical extension of the Src family kinase substrate p130Cas. Cell, 127:1015-1026, 2006

8. Molecular Oncology Division

67.  Aikawa Y, Nguyen LA, Isono K, Takakura N, Tagata Y, Schmitz ML, Koseki H, Kitabayashi I. Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation. EMBO J, 25:3955-3965, 2006

68.  Katsumoto T, Aikawa Y, Iwama A, Ueda S, Ichikawa H, Ochiya T, Kitabayashi I. MOZ is essential for maintenance of hematopoietic stem cells. Genes Dev, 20:1321-1330, 2006

69.  Xu G, Kanezaki R, Toki T, Watanabe S, Takahashi Y, Terui K, Kitabayashi I, Ito E. Physical association of the patient-specific GATA1 mutants with RUNX1 in acute megakaryoblastic leukemia accompanying Down syndrome. Leukemia, 20:1002-1008, 2006

9. Virology Division

70.  Goto H, Kiyono T, Tomono Y, Kawajiri A, Urano T, Furukawa K, Nigg EA, Inagaki M. Complex formation of Plk1 and INCENP required for metaphase-anaphase transition. Nat Cell Biol, 8:180-187, 2006

71.  Mizumoto Y, Kyo S, Ohno S, Hashimoto M, Nakamura M, Maida Y, Sakaguchi J, Takakura M, Inoue M, Kiyono T. Creation of tumorigenic human endometrial epithelial cells with intact chromosomes by introducing defined genetic elements. Oncogene, 25:5673-5682, 2006

72.  Hashimoto N, Kiyono T, Wada MR, Shimizu S, Yasumoto S, Inagawa M. Immortalization of human myogenic progenitor cell clone retaining multipotentiality. Biochem Biophys Res Commun, 348:1383-1388, 2006

73.  Yamashita Y, Tsurumi T, Mori N, Kiyono T. Immortalization of Epstein-Barr virus-negative human B lymphocytes with minimal chromosomal instability. Pathol Int, 56:659-667, 2006

74.  Ito Y, Hasauda H, Kitajima T, Kiyono T. Ex vivo expansion of human cord blood hematopoietic progenitor cells using glutaraldehyde-fixed human bone marrow stromal cells. J Biosci Bioeng, 102:467-469, 2006

75.  Fujita M. Cdt1 revisited: complex and tight regulation during the cell cycle and consequences of deregulation in mammalian cells. Cell Div, 1:22, 2006

76.  Fujita, M. DNA replication initiation. In: Ganten D, Ruckpaul K (eds), Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine. Berlin Heidelberg & New York, Springer, pp 446-449, 2006

77.  Nishitani H, Sugimoto N, Roukos V, Nakanishi Y, Saijo M, Obuse C, Tsurimoto T, Nakayama KI, Nakayama K, Fujita M, Lygerou Z, Nishimoto T. Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis. EMBO J, 25:1126-1136, 2006

78.  Tatsumi Y, Sugimoto N, Yugawa T, Narisawa-Saito M, Kiyono T, Fujita M. Deregulation of Cdt1 induces chromosomal damage without rereplication and leads to chromosomal instability. J Cell Sci, 119:3128-3140, 2006

10. Genetics Division

79.  Ashida A, Boku N, Aoyagi K, Sato H, Tsubosa Y, Minashi K, Muto M, Ohtsu A, Ochiai A, Yoshida T, Yoshida S, Sasaki H. Expression profiling of esophageal squamous cell carcinoma patients treated with definitive chemoradiotherapy: Clinical implications. Int J Oncol, 28:1345-1352, 2006

80.  Takahashi H, Aoyagi K, Nakanishi Y, Sasaki H, Yoshida T, Honda H. Classification of intramural metastases and lymph node metastases of esophageal cancer from gene expression based on boosting and projective adaptive resonance theory. J Biosci Bioeng, 102:46-52, 2006

81.  Kim DH, Muto M, Kuwahara Y, Nakanishi Y, Watanabe H, Aoyagi K, Ogawa K, Yoshida T, Sasaki H. Array-based comparative genomic hybridization of circulating esophageal tumor cells. Oncol Rep, 16:1053-1059, 2006

82.  Daiko H, Isohata N, Sano M, Aoyagi K, Ogawa K, Kameoka S, Yoshida T, Sasaki H. Molecular profiles of the mouse postnatal development of the esophageal epithelium showing delayed growth start. Int J Mol Med, 18:1057-1066, 2006

83.  Fukaya M, Isohata N, Ohta H, Aoyagi K, Ochiya T, Saeki N, Yanagihara K, Nakanishi Y, Taniguchi H, Sakamoto H, Shimoda T, Nimura Y, Yoshida T, Sasaki H. Hedgehog signal activation in gastric pit cell and in diffuse-type gastric cancer. Gastroenterology, 131:14-29, 2006

84.  Usui T, Aoyagi K, Saeki N, Nakanishi Y, Kanai Y, Ohki M, Ogawa K, Yoshida T, Sasaki H. Expression status of RUNX1/AML1 in normal gastric epithelium and its mutational analysis in microdissected gastric cancer cells. Int J Oncol, 29:779-784, 2006

85.  Zhang J, Ohta T, Maruyama A, Hosoya T, Nishikawa K, Maher JM, Shibahara S, Itoh K, Yamamoto M. BRG1 interacts with Nrf2 to selectively mediate HO-1 induction in response to oxidative stress. Mol Cell Biol, 26:7942-7952, 2006

86.  Padmanabhan B, Tong KI, Ohta T, Nakamura Y, Scharlock M, Ohtsuji M, Kang M-I, Kobayashi A, Yokoyama S, Yamamoto M. Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. Molecular Cell, 21:689-700, 2006

87.  Sato Y, Suganami H, Hamada C, Yoshimura I, Sakamoto H, Yoshida T, Yoshimura K. The confidence interval of allelic odds ratios under the Hardy-Weinberg disequilibrium. J Hum Genet, 51:772-780, 2006

88.  Katoh M, Katoh M. Bioinformatics for cancer management in the post-genome era. Technol Cancer Res Treat, 5:169-175, 2006

89.  Maeda N, Kasukawa T, Oyama R, Gough J, Frith M, Engstr?m PG, Lenhard B, Aturaliya RN, Batalov S, Beisel KW, Bult CJ, Fletcher FC, Forrest ARR, Furuno M, Hill D, Itoh M, Kanamori-Katayama M, Katayama S, Katoh M, Kawawshima T, Quackenbush J, Ravasi T, Ring BZ, Shibata K, Sugiura K, Takenaka Y, Teasdale RD, Wells CA, Zhu Y, Kai C, Kawai J, Hume DA, Carninct P, Hayashizaki Y. Transcript annotation in FANTOM3: mouse gene catalog based on physical cDNAs. PLoS Genet, 2:498-503, 2006

90.  Katoh M, Katoh M. Cross-talk of WNT and FGF signaling pathways at GSK3b to regulate b-catenin and SNAIL signaling cascades. Cancer Biol Ther, 5:1059-1064, 2006

91.  Katoh M, Katoh M. FGF signaling network in the gastrointestinal tract (review). Int J Oncol, 29:163-168, 2006

92.  Katoh Y, Katoh M. Hedgehog signaling pathway and gastrointestinal stem cell signaling network (review). Int J Mol Med, 18:1019-1023, 2006

93.  Katoh M, Katoh M. NUMB is a break of WNT-Notch signaling cycle. Int J Mol Med, 18:517-521, 2006

94.  Katoh M, Katoh M. Notch ligand, JAG1, is evolutionarily conserved target of canonical WNT signaling pathway in progenitor cell. Int J Mol Med, 17:681-685, 2006

95.  Katoh Y, Katoh M. WNT antagonist, SFRP1, is Hedgehog signaling target. Int J Mol Med, 17:171-175, 2006

96.  Katoh M, Katoh M. CER1 is a common target of WNT and NODAL signaling pathways in human embryonic stem cells. Int J Mol Med, 17:795-799, 2006

97.  Katoh Y, Katoh M. Comparative integromics on BMP/GDF family. Int J Mol Med, 17:951-955, 2006

98.  Katoh M, Katoh M. Comparative integromics on Eph family. Int J Oncol, 28:1243-1247, 2006

99.  Katoh Y, Katoh M. Comparative integromics on VEGF family members. Int J Oncol, 28:1585-1589, 2006

100.  Katoh Y, Katoh M. Canonical WNT signaling pathway and human AREG. Int J Mol Med, 17:1163-1166, 2006

101.  Katoh Y, Katoh M. Comparative integromics on Angiopoietin family members. Int J Mol Med, 17:1145-1149, 2006

102.  Katoh Y, Katoh M. FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cell. Int J Mol Med, 17:529-532, 2006

103.  Katoh Y, Katoh M. Comparative integromics on FAT1, FAT2, FAT3 and FAT4. Int J Mol Med, 18:523-528, 2006

104.  Katoh Y, Katoh M. Comparative genomics on HHIP family orthologs. Int J Mol Med, 17:391-395, 2006

105.  Nitta T, Mariam N, Seike T, Giji A, Ohigashi I, Miyazaki T, Ohta T, Kanno M, Takahama Y. IAN family critically regulates survival and development of T lymphocytes. PLOS Biol, 4: e103, 2006

11. Radiobiology Division

106.  Enari M, Ohmori K, Kitabayashi I, Taya Y. Requirement of clathrin heavy chain for p53-mediated transcription. Genes Develop, 20:1087-1099, 2006

107.  Ziv Y, Bielopolski D, Galanty Y, Lukas C, Taya Y, Schultz DC, Lukas J, Bekker-Jensen S, Bartek J, Shiloh Y. Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway. Nat Cell Biol, 8:870-876, 2006

108.  Okamoto K, Kitabayashi I, Taya Y. KAP1 dictates p53 response induced by chemotherapeutic agents via Mdm2 interaction. Biochem Biophys Res Commun, 351:216-222, 2006

109.  Pereg Y, Lam S, Teunisse A, Biton S, Meulmeester E, Mittelman L, Buscemi G, Okamoto K, Taya Y, Shiloh Y, Jochemsen AG. Differential Roles of ATM-and Chk2-Mediated Phosphorylations of Hdmx in Response to DNA Damage. Mol Cell Biol, 26:6819-6831, 2006

110.  Ohkubo S, Tanaka T, Taya Y, Kitazato K, Prives C. Excess HDM2 impacts cell cycle and apoptosis and has a selective effect on p53-dependent transcription. J Biol Chem, 281:16943-16950, 2006

12. Carcinogenesis Division

111.  Lieb JD, Beck S, Bulyk ML, Farnham P, Hattori N, Henikoff S, Liu XS, Okumura K, Shiota K, Ushijima T, Greally JM. Applying whole-genome studies of epigenetic regulation to study human disease. Cytogenet Genome Res, 114:1-15, 2006

112.  Murayama A, Sakura K, Nakama M, Yasuzawa-Tanaka K, Fujita E, Tateishi Y, Wang Y, Ushijima T, Baba T, Shibuya K, Shibuya A, Kawabe Y, Yanagisawa J. A specific CpG site demethylation in the human interleukin 2 gene promoter is an epigenetic memory. EMBO J, 25:1081-1092, 2006

113.  Maekita T, Nakazawa K, Mihara M, Nakajima T, Yanaoka K, Iguchi M, Arii K, Kaneda A, Tsukamoto T, Tatematsu M, Tamura G, Saito D, Sugimura T, Ichinose M, Ushijima T. High levels of aberrant DNA methylation in Helicobacter pylori-infected gastric mucosae and its possible association with gastric cancer risk. Clin Cancer Res, 12:989-995, 2006

114.  Nakajima T, Maekita T, Oda I, Gotoda T, Yamamoto S, Umemura S, Ichinose M, Sugimura T, Ushijima T, Saito D. Higher methylation levels in gastric mucosae significantly correlate with higher risk of gastric cancers. Cancer Epidemiol Biomarkers Prev, 15:2317-2321, 2006

115.  Ushijima T, Nakajima T, Maekita T. DNA methylation as a marker for the past and future. J Gastroenterol, 41:401-407, 2006

116.  Watanabe N, Okochi-Takada E, Yagi Y, Furuta J, Ushijima T. Decreased fidelity in replicating DNA methylation patterns in cancer cells leads to dense methylation of a CpG island. Curr Top Microbiol Immunol, 310:199-210, 2006

117.  Furuta J, Nobeyama Y, Umebayashi Y, Otsuka F, Kikuchi K, Ushijima T. Silencing of Peroxiredoxin 2 and aberrant methylation of 33 CpG islands in putative promoter regions in human malignant melanomas. Cancer Res, 66:6080-6086, 2006

118.  Imura M, Yamashita S, Cai L-Y, Furuta J, Wakabayashi M, Yasugi T, Ushijima T. Methylation and expression analysis of 15 genes and three normally-methylated genes in 13 Ovarian cancer cell lines. Cancer Lett, 241:213-220, 2006

119.  Yamashita S, Tsujino Y, Moriguchi K, Tatematsu M, Ushijima T. Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray. Cancer Sci, 97:64-71, 2006

120.  Okochi-Takada E, Nakazawa K, Wakabayashi M, Mori A, Ichimura S, Yasugi T, Ushijima T. Silencing of the UCHL1 gene in human colorectal and ovarian cancers. Int J Cancer, 119:1338-1344, 2006

121.  Hatada I, Fukasawa M, Kimura M, Morita S, Yamada K, Yoshikawa T, Yamanaka S, Endo C, Sakurada A, Sato M, Kondo T, Horii A, Ushijima T, Sasaki H. Genome-wide profiling of promoter methylation in human. Oncogene, 25:3059-3064, 2006

122.  Mihara M, Yoshida Y, Tsukamoto T, Inada K, Nakanishi Y, Yagi Y, Imai K, Sugimura T, Tatematsu M, Ushijima T. Methylation of multiple genes in gastric glands with intestinal metaplasia. Am J Pathol, 169:1643-1651, 2006

13. Section for Studies on Metastasis

123.  Takeshita F, Ochiya T. Therapeutic potential of RNA interference against cancer. Cancer Sci, 97:689-696, 2006

124.  Kurokawa Y, Honma K, Takemasa I, Nakamori S, Kita-Matsuo H, Motoori M, Nagano H, Dono K, Ochiya T, Monden M, Kato K. Central genetic alterations common to all HCV-positive, HBV-positive and non-B, non-C hepatocellular carcinoma: a new approach to identify novel tumor markers. Int J Oncol, 28:383-391, 2006

125.  Fujii T, Saito M, Iwasaki E, Ochiya T, Takei Y, Hayashi S, Ono A, Hirao N, Nakamura M, Kubushiro K, Tsukazaki K, Aoki D. Intratumor injection of small interfering RNA-targeting human papillomavirus 18 E6 and E7 successfully inhibits the growth of cervical cancer. Int J Oncol, 29:541-548, 2006

126.  Hanai K, Takeshita F, Honma K, Nagahara S, Maeda M, Minakuchi Y, Sano A, Ochiya T. Atelocollagen-mediated systemic DDS for nucleic acid medicines. Ann N Y Acad Sci, 1082:9-17, 2006

127.  Takeshita F, Ochiya T. Approaches for RNAi therapeutics against cancer. In: Takaku H, Yamamoto N (eds), RNAi Therapeutics. India, Research Signpost, pp 101-116, 2006

128.  Fukasawa M, Morita S, Kimura M, Horii T, Ochiya T, Hatada I. Genomic imprinting in Dicer1-hypomorphic mice. Cytogenet Genome Res, 113:138-143, 2006

129.  Takeshita F, Kodama M, Yamamoto H, Ikarashi Y, Ueda S, Teratani T, Yamamoto Y, Tamatani T, Kanegasaki S, Ochiya T, Quinn G. Streptozotocin-induced partial beta cell depletion in nude mice without hyperglycaemia induces pancreatic morphogenesis in transplanted embryonic stem cells. Diabetlogia, 49:2948-2958, 2006

130.  Banas A, Quinn G, Yamamoto Y, Teratani T, Ochiya T. Stem cells into liver: basic research and potential clinical applications. Adv Exp Med Biol, 585: 3-17, 2006

131.  Kosaka N, Kodama M, Sasaki H, Yamamoto Y, Takeshita F, Takahama Y, Sakamoto H, Kato T, Terada M, Ochiya T. FGF-4 regulates neural progenitor cell proliferation and neuronal differentiation. FASEB J, 20:1484-1485, 2006

132.  Ueda S, Fukamachi K, Matsuoka Y, Takasuka N, Takeshita F, Naito A, Iigo M, Alexander DB, Moore MA, Saito I, Ochiya T, Tsuda H. Ductal origin of pancreatic adenocarcinomas induced by conditional activation of a human Ha-ras oncogene in rat pancreas. Carcinogenesis, 27:2497-2510, 2006

14. Section for Studies on Host-Immune Response

133.  Ohashi M, Kobayashi A, Hara H, Miura Y, Yoshida K, Kushida M, Ikarashi Y, Mandai M, Kitajima M, Yoshida T, Aoki K. Allogeneic MHC gene transfer enhances antitumor activity of allogeneic hematopoietic stem cell transplantation without exacerbating graft-versus-host disease. Clin Cancer Res, 12:2208-2215, 2006

15. ADP-Ribosylation in Oncology Project

134.  Ogino H, Shibata A, Gunji A, Suzuki H, Nakagama H, Sugimura T, Masutani M. Agent-dependent effects of Parp-1 deficiency on DNA damage responses and genomic stability in mouse ES cells. In: Grier EV (ed), New Developments in Stem Cell Research, Hauppauge, New York, USA, Nova Science Publishers, Inc, pp 133-147, 2006

135.  Hochegger H, Dejsuphong D, Fukushima T, Morrison C, Sonoda E, Schreiber V, Zhao GY, Saberi A, Masutani M, Adachi N, Koyama H, de Murcia G, Takeda S. Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells. EMBO J, 25:1305-1314, 2006

136.  Dominguez-Bendala J, Masutani M, McWhir J. Down-regulation of PARP-1, but not Ku80 or DNA-PKcs, results in higher targeting efficiency in ES cells. Cell Biol Int, 30:389-393, 2006

137.  Ogawa K, Masutani M, Kato K, Tang M, Kamada N, Suzuki H, Nakagama H, Sugimura T, Shirai T. Parp-1 deficiency does not enhance liver carcinogenesis induced by 2-amino-3-methylimidazo[4,5-f]quinoline in mice. Cancer Lett, 236:32-38, 2006

138.  Gunji A, Uemura A, Tsutsumi M, Nozaki T, Kusuoka O, Omura K, Suzuki H, Nakagama H, Sugimura T, Masutani M. Parp-1 deficiency does not increase the frequency of tumors in the oral cavity and esophagus of ICR/129Sv mice by 4-nitroquinoline 1-oxide, a carcinogen producing bulky adducts. Cancer Lett, 241:87-92, 2006

16. Cancer Genomics Project

139.  Katoh H, Shibata T, Kokubu A, Ojima H, Fukayama M, Kanai Y, Hirohashi S. Epigenetic instability and chromosomal instability in hepatocellular carcinoma. Am J Pathol, 168:1375-1384, 2006

140.  Katoh H, Shibata T, Kokubu A, Ojima H, Kosuge T, Kanai Y, Hirohashi S. Genetic Inactivation of the APC gene contributes to the malignant progression of sporadic hepatocellular carcinoma: a case report. Genes Chromosomes Cancer, 45:1050-1057, 2006

17. Cancer Prevention Basic Research Project

141.  Oda Y, Totsuka Y, Wakabayashi K, Guengerich FP, Shimada T. Activation of aminophenylnorharman, aminomethylphenylnorharman and aminophenylharman to genotoxic metabolites by human N-acetyltransferases and cytochrome P450 enzymes expressed in Salmonella typhimurium umu tester strains. Mutagenesis, 21:411-416, 2006

142.  Totsuka Y, Nishigaki R, Sugimura T, Wakabayashi K. The possible involvement of mutagenic and carcinogenic heterocyclic amines in human cancer. In: Skog K, Alexander J (eds), Acrylamide and Other Health Hazardous Compounds in Heat-treated Foods. Cambridge, England, Woodhead Publishing Ltd, pp 296-327, 2006

143.  Watanabe T, Ohba H, Asanoma M, Hasei T, Takamura T, Terao Y, Shiozawa T, Hirayama T, Wakabayashi K, Nukaya H. Isolation and identification of non-chlorinated phenylbenzotriazole (non-ClPBTA)-type mutagens in the Ho River in Shizuoka Prefecture, Japan. Mutat Res, 609:137-145, 2006

144.  Takamura-Enya T, Enomoto S, Wakabayashi K. Palladium-catalyzed direct N-arylation of nucleosides, nucleotides, and oligonucleotides for efficient preparation of dG-N² adducts with carcinogenic amino-/nitroarenes. J Org Chem, 71:5599-5606, 2006

145.  Takamura-Enya T, Ishikawa S, Mochizuki M, Wakabayashi K. Chemical synthesis of 2'-deoxyguanosine-C8 adducts with heterocyclic amines: an application to synthesis of oligonucleotides site-specifically adducted with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Chem Res Toxicol, 19:770-778, 2006

146.  Tamura T, Mitsumori K, Totsuka Y, Wakabayashi K, Kido R, Kasai H, Nasu M, Hirose M. Absence of in vivo genotoxic potential and tumor initiation activity of kojic acid in the rat thyroid. Toxicol, 222:213-224, 2006

147.  Watanabe T, Hasei T, Hirayama T, Wakabayashi K. Detection of 3,3'-dichlorobenzidine in water from the Waka River in Wakayama, Japan. Gene Environment, 28:173-180, 2006

148.  Mukaisho K, Miwa K, Totsuka Y, Shimomura A, Sugihara H, Wakabayashi K, Hattori T. Induction of gastric GIST in rat and establishment of GIST cell line. Cancer Lett, 231:295-303, 2006

149.  Kang JS, Wanibuchi H, Morimura K, TotsukaY, Yoshimura I, Fukushima S. Existence of a no effect level for MeIQx hepatocarcinogenicity on a background of thioacetamide-induced liver damage in rats. Cancer Sci, 97:453-458, 2006

150.  Ohe T, Mizuno T, Morisawa T, Kiritani S, Suzuki S, Takehana H, Kasetani S, Watanabe T, Nukaya H, Shiozawa T, Terao Y, Wakabayashi K. Mutagenicity and levels of 2-phenylbenzotriazole (PBTA)-type mutagens in sewage effluent, river water, sediment and drinking water collected from the Yodo River system, Japan. Gene Environment, 28:108-119, 2006

151.  Suzuki R, Kohno H, Suzui M, Yoshimi N, Tsuda H, Wakabayashi K, Tanaka T. An animal model for the rapid induction of tongue neoplasms in human c-Ha-ras proto-oncogene transgenic rats by 4-nitroquinoline 1-oxide: its potential use for preclinical chemoprevention studies. Carcinogenesis, 27:619-630, 2006

152.  Ohta T, Takahashi M, Ochiai A. Increased protein expression of both inducible nitric oxide synthase and cyclooxygenase-2 in human colon cancers. Cancer Lett, 239:246-253, 2006

153.  Mutoh M, Takahashi M, Wakabayashi K. Roles of prostanoids in colon carcinogenesis and their potential targeting for cancer chemoprevention. Curr Pharm Des, 12:2375-2382, 2006

154.  Tanaka T, Kohno H, Suzuki R, Hata K, Sugie S, Niho N, Sakano K, Takahashi M, Wakabayashi K. Dextran sodium sulfate strongly promotes colorectal carcinogenesis in Apc^Min/+ mice: Inflammatory stimuli by dextran sodium sulfate results in development of multiple colonic neoplasms. Int J Cancer, 118:25-34, 2006

155.  Takahashi M, Mutoh M, Shoji Y, Sato H, Kamanaka Y, Naka M, Maruyama T, Sugimura T, Wakabayashi K. Suppressive effect of an inducible nitric oxide inhibitor, ONO-1714, on AOM-induced rat colon carcinogenesis. Nitric Oxide, 14:130-136, 2006

156.  Niho N, Kitamura T, Takahashi M, Mutoh M, Sato H, Matsuura M, Sugimura T, Wakabayashi K. Suppression of azoxymethane-induced colon cancer development in rats by a cyclooxygenase-1 selective inhibitor, mofezolac. Cancer Sci, 97:1011-1014, 2006

157.  Niho N, Mutoh M, Sakano K, Takahashi M, Hirano S, Nukaya H, Sugimura T, Wakabayashi K. Inhibition of intestinal carcinogenesis by a new flavone derivative, chafuroside, in oolong tea. Cancer Sci, 97:248-251, 2006

158.  Mutoh M, Niho N, Wakabayashi K. Concomitant suppression of hyperlipidemia and intestinal polyp formation by increasing lipoprotein lipase activity in Apc-deficient mice. Biol Chem, 387:381-385, 2006

159.  Mutoh M, Akasu T, Takahashi M, Niho N, Yoshida T, Sugimura T, Wakabayashi K. Possible involvement of hyperlipidemia in increasing risk of colorectal tumor development in human familial adenomatous polyposis. Jpn J Clin Oncol, 36:166-171, 2006

160.  Ueno H, Sato T, Yamamoto S, Tanaka K, Ohkawa S, Takagi H, Yokosuka O, Furuse J, Saito H, Sawaki A, Kasugai H, Osaki Y, Fujiyama S, Sato K, Wakabayashi K, Okusaka T. Randomized, double-blind, placebo-controlled trial of bovine lactoferrin in patients with chronic hepatitis C. Cancer Sci, 97:1105-1110, 2006

161.  Tsuda H, Fukamachi K, Xu J, Sekine K, Ohkubo S, Takasuka N, Iigo M. Prevention of carcinogenesis and cancer metastasis by bovine lactoferrin. Proc Jpn Acad Ser B, 82:208-215, 2006

162.  Sakano K, Takahashi M, Kitano M, Sugimura T, Wakabayashi K. Suppression of azoxymethane-induced colonic premalignant lesion formation by coenzyme Q10 in rats. Asian Pac J Cancer Prev, 7:599-603, 2006

163.  Shiotani B, Kobayashi M, Watanabe M, Yamamoto K, Sugimura T, Wakabayashi K. Involvement of the ATR- and ATM-dependent checkpoint responses in cell cycle arrest evoked by pierisin-1. Mol Cancer Res, 4:125-133, 2006

164.  Nakano T, Matsushima-Hibiya Y, Yamamoto M, Enomoto S, Matsumoto Y, Totsuka Y, Watanabe M, Sugimura T, Wakabayashi K. Purification and molecular cloning of a DNA ADP-ribosylating protein, CARP-1, from the edible clam Meretrix lamarckii. Proc Natl Acad Sci U S A, 103:13652-13657, 2006

18. Cancer Transcriptome Project

165.  Ichikawa H, Tanabe K, Mizushima H, Hayashi Y, Mizutani S, Ishii E, Hongo T, Kikuchi A, Satake M. Common gene expression signatures in t(8;21)- and inv(16)-acute myeloid leukaemia. Br J Haematol, 135:336-347, 2006

166.  Hayashida N, Inoue S, Fujimoto M, Tanaka Y, Izu H, Takaki E, Ichikawa H, Rho J, Nakai A. A novel HSF1-mediated death pathway that is suppressed by heat shock proteins. EMBO J, 25:4773-4783, 2006

167.  Shen Y, Jia Z, Nagele RG, Ichikawa H, Goldberg GS. Src uses Cas to suppress Fhl1 in order to promote nonanchored growth and migration of tumor cells. Cancer Res, 66:1543-1552, 2006

19. Proteome Bioinformatics Project

168.  Suehara Y, Kondo T, Fujii K, Hasegawa T, Kawai A, Seki K, Beppu Y, Nishimura T, Kurosawa H, Hirohashi S. Proteomic signatures corresponding to histological classification and grading of soft-tissue sarcomas. Proteomics, 6:4402-4409, 2006

169.  Hatakeyama H, Kondo T, Fujii K, Nakanishi Y, Kato H, Fukuda S, Hirohashi S. Protein clusters associated with carcinogenesis, histological differentiation and nodal metastasis in esophageal cancer. Proteomics, 6:6300-6316, 2006

170.  Okano T, Kondo T, Kakisaka T, Fujii K, Yamaad M, Kato H, Nishimura T, Gemma A, Kudoh S, Hirohashi S. Plasma proteomics of lung cancer by a linkage of multi-dimensional liquid chromatography and two-dimensional difference gel electrophoresis. Proteomics, 6:3938-3948, 2006

171.  Fujii K, Kondo T, Yokoo H, Okano T, Yamada M, Yamada T, Iwatsuki K, Hirohashi S. Database of two-dimensional polyacrylamide gel electrophoresis of proteins labeled with CyDye DIGE Fluor saturation dye. Proteomics, 6:1640-1653, 2006

172.  Fujii K, Kondo T, Yamada M, Iwatsuki K, Hirohashi S. Toward a comprehensive quantitative proteome database: proteome expression map of lymphoid neoplasms by 2-D DIGE and MS. Proteomics, 6:4856-4876, 2006

20. Tumor Endocrinology Project

173.  Naito J, Kaji H, Sowa H, Kitazawa R, Kitazawa S, Tsukada T, Hendy GN, Sugimoto T, Chihara K. Expression and functional analysis of menin in a multiple endocrine neoplasia type 1 (MEN1) patient with somatic loss of heterozygosity in chromosome 11q13 and unidentified germline mutation of the MEN1 gene. Endocrine, 29:485-490, 2006

174.  Fukuuchi A, Nagamura Y, Yaguchi H, Ohkura N, Obara T, Tsukada T. A whole MEN1 gene deletion flanked by Alu repeats in a family with multiple endocrine neoplasia type 1. Jpn J Clin Oncol, 36:739-744, 2006

175.  Takahashi M, Kikuchi M, Ohkura N, Yaguchi H, Nagamura Y, Ohnami S, Ushiama M, Yoshida T, Sugano K, Iwama T, Kosugi S, Tsukada T. Detection of APC gene deletion by double competitive polymerase chain reaction in patients with familial adenomatous polyposis. Int J Oncol, 29:413-421, 2006

176.  Nomiyama T, Nakamachi T, Gizard F, Heywood EB, Jones KL, Ohkura N, Kawamori R, Conneely OM, Bruemmer D. The NR4A orphan nuclear receptor NOR1 is induced by platelet-derived growth factor and mediates vascular smooth muscle cell proliferation. J Biol Chem, 281:33467-33476, 2006

177.  Pearen MA, Ryall JG, Maxwell MA, Ohkura N, Lynch GS, Muscat GE. The orphan nuclear receptor, NOR-1, is a target of b-adrenergic signaling in skeletal muscle. Endocrinology, 147:5217-5227, 2006

21. Tumor Suppression and Functional Genomics Project

178.  Kikuchi S, Yamada D, Fukami T, Maruyama T, Ito A, Asamura H, Matsuno Y, Onizuka M, Murakami Y. Hypermethylation of the TSLC1/IGSF4 promoter is associated with tobacco smoking and a poor prognosis in primary nonsmall cell lung carcinoma. Cancer, 106:1751-1758, 2006

179.  Lung HL, Cheung AKL, Dan X, Cheng Y, Kwong FM, Murakami Y, Guan X-Y, Sham JS, Chua D, Protopopov AI, Zabarovsky ER, Tsao SW, Stanbridge EJ, Lung ML. TSLC1 is a tumor suppressor gene associated with metastasis in nasopharyngeal carcinoma. Cancer Res, 66:9385-9392, 2006

180.  Yamada D, Kikuchi S, Williams YN, Sakurai-Yageta M, Masuda M, Maruyama T, Tomita K, Gutmann DH, Kakizoe T, Kitamura T, Kanai Y, Murakami Y. Promoter hypermethylation of the potential tumor suppressor DAL-1/4.1B gene in renal clear cell carcinoma. Int J Cancer, 118:916-923, 2006

181.  Yamada D, Yoshida M, Williams YN, Fukami T, Kikuchi S, Masuda M, Maruyama T, Ohta T, Nakae D, Maekawa A, Kitamura T, Murakami Y. Disruption of spermatogenic cell adhesion and male infertility in mice lacking TSLC1/IGSF4, an immunoglobulin superfamily cell adhesion molecule. Mol Cell Biol, 26:3610-3624, 2006

182.  van der Weyden L, Arends MJ, Chausiaux OE, Ellis PJ, Lange UC, Surani MA, Affara N, Murakami Y, Adams DJ, Allan B. Loss of TSLC1 causes male infertility due to a defect at the spermatid stage of spermatogenesis. Mol Cell Biol, 26:3595-3609, 2006

183.  Williams YN, Masuda M, Sakurai-Yageta M, Maruyama T, Shibuya M, Murakami Y. Cell adhesion and prostate tumor-suppressor activity of TSLL2/IGSF4C, an immunoglobulin superfamily molecule homologous to TSLC1/IGSF4. Oncogene, 25:1446-1453, 2006

22. Epidemiology and Prevention Division

184.  Inoue M, Iwasaki M, Otani T, Sasazuki S, Noda M, Tsugane S, for the Japan Public Health Center-Based Prospective Study Group. Diabetes mellitus and the risk of cancer. Arch Intern Med, 166:1871-1877, 2006

185.  Nitadori J, Inoue M, Iwasaki M, Otani T, Sasazuki S, Nagai K, Tsugane S, the JPHC Study Group. Association between lung cancer incidence and family history of lung cancer. Chest, 130:968-975, 2006

186.  Lee K-J, Inoue M, Otani T, Iwasaki M, Sasazuki S, Tsugane S, the JPHC Study Group. Gastric cancer screening and subsequent risk of gastric cancer: a large-scale population-based cohort study, with a 13-year follow-up in Japan. Int J Cancer, 118:2315-2321, 2006

187.  Kurahashi N, Iwasaki M, Sasazuki S, Otani T, Inoue M, Tsugane S, the JPHC Study Group. Association of body mass index and height with risk of prostate cancer among middle-aged Japanese men. Br J Cancer, 94:740-742, 2006

188.  Otani T, Iwasaki M, Inoue M, Sasazuki S, Tsugane S; For the Japan Public Health Center-based prospective study group. Bowel movement, state of stool, and subsequent risk for colorectal cancer: the Japan Public Health Center-based prospective study. Ann Epidemiol, 16:888-894, 2006

189.  Otani T, Iwasaki M, Ishihara J, Sasazuki S, Inoue M, Tsugane S, the Japan Public Health Center-Based Prospective Study Group. Dietary fiber intake and subsequent risk of colorectal cancer: The Japan Public Health Center-Based Prospective Study. Int J Cancer, 119:1475-1480, 2006

190.  Otani T, Iwasaki M, Sasazuki S, Inoue M, Tsugane S, Japan Public Health Center-Based Prospective Study Group. Plasma C-reactive protein and risk of colorectal cancer in a nested case-control study: Japan Public Health Center-Based Prospective Study. Cancer Epidemiol Biomarkers Prev, 15:690-695, 2006

191.  Sasazuki S, Inoue M, Iwasaki M, Otani T, Yamamoto S, Ikeda S, Hanaoka T, Tsugane S, the Japan Public Health Center Study Group. Effect of Helicobacter pylori infection combined with CagA and pepsinogen status on gastric cancer development among Japanese men and women: a nested case-control study. Cancer Epidemiol Biomarkers Prev, 15:1341-1347, 2006

192.  Iso H, Kobayashi M, Ishihara J, Sasaki S, Okada K, Kita Y, Kokubu Y, Tsugane S, the JPHC Study Group. Intake of fish and n3 fatty acids and risk of coronary heart disease among Japanese The Japan Public Health Center-Based (JPHC) Study Cohort I. Circulation, 113:195-202, 2006

193.  Baba S, Iso H, Mannami T, Sasaki S, Okada K, Konishi M, Tsugane S, the JPHC Study Group. Cigarette smoking and risk of coronary heart disease incidence among middle-aged Japanese men and women: the JPHC Study Cohort I. Eur J Cardiovasc Prev Rehabil, 13:207-213, 2006

194.  Nakamura Y, Iso H, Kita Y, Ueshima H, Okada K, Konishi M, Inoue M, Tsugane S, the Japan Public Health Center-based prospective study group. Egg consumption, serum total cholesterol concentrations and coronary heart disease incidence: Japan Public Health Center-based prospective study. Br J Nutr, 96:921-928, 2006

195.  Akechi T, Iwasaki M, Uchitomi Y, Tsugane S, the JPHC Study Group. Alcohol consumption and suicide among middle-aged men in Japan. Br J Psychiatry, 188:231-236, 2006

196.  Iwasaki M, Yamamoto S, Otani T, Inoue M, Hanaoka T, Sobue T, Tsugane S, the Japan Public Health Center-based Prospective Study (JPHC Study) Group. Generalizability of relative risk estimates from a well-defined population to a general population. Eur J Epidemiol, 21:253-262, 2006

197.  Ishihara J, Inoue M, Kobayashi M, Tanaka S, Yamamoto S, Iso H, Tsugane S, the JPHC FFQ Validation Study Group. Impact of the revision of a nutrient database on the validity of a self-administered food frequency questionnaire (FFQ). J Epidemiol, 16:107-116, 2006

198.  Mizoue T, Inoue M, Tanaka K, Tsuji I, Wakai K, Nagata C, Tsugane S, Research Group for the Development, Evaluation of Cancer Prevention Strategies in Japan. Tobacco smoking and colorectal cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population. Jpn J Clin Oncol, 36:25-39, 2006

199.  Wakai K, Inoue M, Mizoue T, Tanaka K, Tsuji I, Nagata C, Tsugane S, the Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan. Tobacco smoking and lung cancer risk: an evaluation based on a systematic review of epidemiological evidence among the Japanese population. Jpn J Clin Oncol, 36:309-324, 2006

200.  Nagata C, Mizoue T, Tanaka K, Tsuji I, Wakai K, Inoue M, Tsugane S, Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan. Tobacco smoking and breast cancer risk: an evaluation based on a systematic review of epidemiological evidence among the Japanese population. Jpn J Clin Oncol, 36:387-394, 2006

201.  Nishino Y, Inoue M, Tsuji I, Wakai K, Nagata C, Mizoue T, Tanaka K, Tsugane S. Tobacco smoking and gastric cancer risk: An evaluation based on a systematic review of epidemiologic evidence among the Japanese population. Jpn J Clin Oncol, 36:800-807, 2006

202.  Tanaka K, Tsuji I, Wakai K, Nagata C, Mizoue T, Inoue M, Tsugane S, the Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan. Cigarette smoking and liver cancer risk: an evaluation based on a systematic review of epidemiologic evidence among Japanese. Jpn J Clin Oncol, 36:445-456, 2006

203.  Mizoue T, Tanaka K, Tsuji I, Wakai K, Nagata C, Otani T, Inoue M, Tsugane S, the Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan. Alcohol drinking and colorectal Cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population. Jpn J Clin Oncol, 36:582-597, 2006

204.  Inoue M, Iwasaki M, Otani T, Sasazuki S, Tsugane S. Public awareness of risk factors for cancer among the Japanese general population: a population-based survey. BMC Public Health, 6:1-6, 2006

205.  Sasazuki S, Sasaki S, Tsubono Y, Okubo S, Hayashi M, Tsugane S. Effect of vitamin C on common cold: randomized controlled trial. Eur J Clin Nutr, 60:9-17, 2006

206.  Takahashi Y, Sasaki S, Okubo S, Hayashi M, Tsugane S. Blood pressure change in a free-living population-based dietary modification study in Japan. J Hypertens, 24:451-458, 2006

207.  Takahashi Y, Sasaki S, Okubo S, Hayashi M, Tsugane S. Maintenance of a low-sodium, high-carotene and -vitamin C diet after a 1-year dietary intervention: the Hiraka Dietary Intervention Follow-up Study. Prev Med, 43:14-19, 2006

208.  Tsukino H, Hanaoka T, Sasaki H, Motoyama H, Hiroshima M, Tanaka T, Kabuto M, Patterson DGJ, Turner W, Needham L, Tsugane S. Fish intake and serum levels of organochlorines among Japanese women. Sci Total Environ, 359:90-100, 2006

209.  Pan G, Hanaoka T, Yoshimura M, Zhang S, Wang P, Tsukino H, Inoue K, Nakazawa H, Tsugane S, Takahashi K. Decreased serum free testosterone in workers exposed to high levels of di-n-butyl phthalate (DBP) and di-2-ethylhexyl phthalate (DEHP): a cross-sectional study in china. Environ Health Perspect, 114:1643-1648, 2006

210.  Otani T, Iwasaki M, Ikeda S, Kozu T, Saito H, Mutoh M, Wakabayashi K, Tsugane S. Serum triglycerides and colorectal adenoma in a case-control study among cancer screening examinees (Japan). Cancer Causes Control, 17:1245-1252, 2006

211.  Kanaly RA, Hanaoka T, Sugimura H, Toda H, Matsui S, Matsuda T. Development of the adductome approach to detect DNA damage in humans. Antioxid Redox Signal, 8:993-1001, 2006

23. Statistics and Cancer Control Division

212.  Marugame T, Kamo K, Katanoda K, Ajiki W, Sobue T. The Japan Cancer Surveillance Research Group. Cancer incidence and incidence rates in Japan in 2000: Jpn J Clin Oncol, 36:668-675, 2006

213.  Sano H, Saika K. International comparisons of cumulative risk of bladder cancer, from cancer incidence in five continents Vol. VIII. Jpn J Clin Oncol, 36:757-758, 2006

214.  Hirabayashi Y, Sano H. International comparisons of cumulative risk of leukaemia, from cancer incidence in five continents Vol. VIII. Jpn J Clin Oncol, 36:677-678, 2006

215.  Tanaka S, Hirabayashi Y. International comparisons of cumulative risk of oesophagus cancer, from cancer incidence in five continents Vol. VIII. Jpn J Clin Oncol, 36:609-610, 2006

216.  Qiu D, Tanaka S. International comparisons of cumulative risk of skin cancer, from cancer incidence in five continents Vol. VIII. Jpn J Clin Oncol, 36:533-534, 2006

217.  Katanoda K, Qiu D. International comparisons of cumulative risk of uterine cancer, from cancer incidence in five continents Vol. VIII. Jpn J Clin Oncol, 36:474-475, 2006

218.  Marugame T, Katanoda K. International comparisons of cumulative risk of breast and prostate cancer, from cancer incidence in five continents Vol. VIII. Jpn J Clin Oncol, 36:399-400, 2006

219.  Sano H, Marugame T. International comparisons of cumulative risk of lung cancer, from cancer incidence in five continents Vol. VIII. Jpn J Clin Oncol, 36:334-335, 2006

220.  Imamura Y, Sano H. International comparisons of cumulative risk of liver cancer, from cancer incidence in five continents Vol. VIII. Jpn J Clin Oncol, 36:259-260, 2006

221.  Tanaka S, Imamura Y. International comparisons of cumulative risk of colorectal cancer, from cancer incidence in five continents vol. VIII. Jpn J Clin Oncol, 36:186-187, 2006

222.  Qiu D, Tanaka S. International comparisons of cumulative risk of stomach cancer, from cancer incidence in five continents Vol. VIII. Jpn J Clin Oncol, 36:123-124, 2006

223.  Katanoda K, Qiu D. International comparisons of cumulative risk of all-site cancer, from cancer incidence in five continents vol. VIII. Jpn J Clin Oncol, 36:66-68, 2006

224.  Marugame T, Kamo K, Sobue T, Akiba S, Mizuno S, Satoh H, Suzuki T, Tajima K, Tamakoshi A, Tsugane S. Trends in smoking by birth cohorts born between 1900 and 1977 in Japan. Preventive Medicine, 42:120-127, 2006

225.  Katai H, Yoshimura K, Fukagawa T, Sano T, Sasako M. Risk factors for pancreas-related abscess after total gastrectomy. Gastric Cancer, 8:137-141, 2005

226.  Kabuto M, Nitta H, Yamamoto S, Yamaguchi N, Akiba S, Honda Y, Hagihara J, Isaka K, Saito T, Ojima T, Nakamura Y, Mizoue T, Ito S, Eboshida A, Yamazaki S, Sokejima S, Kurokawa Y, Kubo O. Childhood leukemia and magnetic fields in Japan: A case-control study of childhood leukemia and residential power-frequency magnetic fields in Japan. Int J Cancer, 119:643-650, 2006

227.  Hamashima C, Sobue T, Muramatsu Y, Saito H, Moriyama N, Kakizoe T. Comparison of observed and expected numbers of detected cancers in the research center for cancer. Jpn J Clin Oncol, 36:301-308, 2006

228.  Mizoroki F, Hirose Y, Sano M, Fukuda H, Tobinai K, Nakata M, Taniwaki M, Kawano F, Uozumi K, Sawada K, Fukuhara S, Nasu K, Ohno Y, Toki H, Togawa A, Kikuchi M, Hotta T, Shimoyama M, for the Japan Clinical Oncology Group - Lymphoma Study Group. A phase II study of VEPA/FEPP chemotherapy for aggressive lymphoma in elderly patients: Japan Clinical Oncology Group Study JCOG9203. Int J Hematol, 83:55-62, 2006

229.  Ono S, Yoshioka C, Asaka O, Tamura K, Shibata T, Saito K. New drug approval times and clinical evidence in Japan. Contemp Clin Trials, 26:660-672, 2005

230.  Uyama Y, Shibata T, Nagai N, Hanaoka H, Toyoshima S, Mori K. Successful bridging strategy based on ICH E5 guideline for drugs approved in Japan. Clin Pharmacol Ther, 78:102-113, 2005

24. Central Animal Laboratory

231.  Matsukawa Y, Semba S, Kato H, Ito A, Yanagihara K, Yokozaki H. Expression of the enhancer of zeste homolog 2 is correlated with poor prognosis in human gastric cancer. Cancer Sci, 97:484-491, 2006

232.  Ohtawa Y, Naomoto Y, Shirakawa Y, Takaoka M, Murata T, Sonoda R, Sakurama K, Yamatsuji T, Gunduz M, Tsujigawa H, Nagatsuka H, Terada N, Itano S, Horiki S, Yanagihara K, Nakajima M, Tanaka N. The close relationship between heparanase and cyclooxygenase-2 expressions in signet-ring cell carcinoma of the stomach. Hum Pathol, 37:1145-1152, 2006

233.  Sekine A, Akiyama Y, Yanagihara K, Yuasa Y. Hath1 up-regulates gastric mucin gene expression in gastric cells. Biochem Biophys Res Commun, 344:1166-1171, 2006

234.  Yanagihara K, Takigahira M, Takeshita F, Komatsu T, Nishio K, Hasegawa F, Ochiya T. A photon counting technique for quantitatively evaluating progression of peritoneal tumor dissemination. Cancer Res, 66:7532-7539, 2006

25. President Emeritus

235.  Shall S, Sugimura T. What is new about ADP-ribosylation? Bioessays, 28:97-99, 2006

236.  Sugimura T. Congratulatory dedication to Professor Osamu Hayaishi: from Bethesda to Ueno Park (Japan Academy). IUBMB Life, 58:251-252, 2006