1. Pathology Division

1. Kanai Y, Hirohashi S. Alterations of DNA methylation associated with abnormalities of DNA methyltransferases in human cancers during transition from a precancerous to a malignant state. Carcinogenesis, 28:2434-2442, 2007

2. Sawada M, Kanai Y, Arai E, Ushijima S, Ojima H, Hirohashi S. Increased expression of DNA methyltransferase 1 (DNMT1) protein in uterine cervix squamous cell carcinoma and its precursor lesion. Cancer Lett, 251:211-219, 2007

3. Kikuchi R, Tsuda H, Kanai Y, Kasamatsu T, Sengoku K, Hirohashi S, Inazawa J, Imoto I. Promoter hypermethylation contributes to frequent inactivation of a putative conditional tumor suppressor gene connective tissue growth factor in ovarian cancer. Cancer Res, 67:7095-7105, 2007

4. Miyake M, Sugano K, Kawashima K, Ichikawa H, Hirabayashi K, Kodama T, Fujimoto H, Kakizoe T, Kanai Y, Fujimoto K, Hirao Y. Sensitive detection of FGFR3 mutations in bladder cancer and urine sediments by peptide nucleic acid-mediated real-time PCR clamping. Biochem Biophys Res Commun, 362:865-871, 2007

5. Hayashi T, Kobayashi Y, Horiuchi A, Hiraoka N, Kubota N, Kanai Y, Aburatani H, Konishi I, Sano K. Interferon-g and cancer immunoediting: insights from tumorgenesis of uterine leiomyosarcoma. Curr Res Immunol, 1:33-46, 2007

6. Kobayashi N, Hiraoka N, Yamagami W, Ojima H, Kanai Y, Kosuge T, Nakajima A, Hirohashi S. FOXP3⁺ regulatory T cells affect the development and progression of hepatocarcinogenesis. Clin Cancer Res, 13:902-911, 2007

7. Takahashi Y, Akishima-Fukasawa Y, Kobayashi N, Sano T, Kosuge T, Nimura Y, Kanai Y, Hiraoka N. Prognostic value of tumor architecture, tumor-associated vascular characteristics, and expression of angiogenic molecules in pancreatic endocrine tumors. Clin Cancer Res, 13:187-196, 2007

8. Izumi T, Oda Y, Hasegawa T, Nakanishi Y, Kawai A, Sonobe H, Takahira T, Kobayashi C, Yamamoto H, Tamiya S, Hirohashi S, Iwamoto Y, Tsuneyoshi M. Dysadherin expression as a significant prognostic factor and as a determinant of histologic features in synovial sarcoma: special reference to its inverse relationship with E-cadherin expression. Am J Surg Pathol, 31:85-94, 2007

9. Nakanishi Y, Saka M, Eguchi T, Sekine S, Taniguchi H, Shimoda T. Distribution and significance of the oesophageal and gastric cardiac mucosae: a study of 131 operation specimens. Histopathology, 51:515-519, 2007

10. Ishibashi Y, Ojima H, Hiraoka N, Sano T, Kosuge T, Kanai Y. Invasive biliary cystic tumor without ovarian-like stroma. Pathol Int, 57:794-798, 2007

11. Sentani K, Nakanishi Y, Ojima H, Hamaguchi T, Shimoda T. Esophageal squamous cell carcinoma presenting with systemic arterial embolism. Pathol Int, 57:96-100, 2007

12. Nunobe S, Nakanishi Y, Taniguchi H, Sasako M, Sano T, Kato H, Yamagishi H, Sekine S, Shimoda T. Two distinct pathways of tumorigenesis of adenocarcinomas of the esophagogastric junction, related or unrelated to intestinal metaplasia. Pathol Int, 57:315-321, 2007

13. Uehara K, Nakanishi Y, Shimoda T, Taniguchi H, Akasu T, Moriya Y. Clinicopathological significance of microscopic abscess formation at the invasive margin of advanced low rectal cancer. Br J Surg, 94:239-243, 2007

14. Uehara K, Shimoda T, Nakanishi Y, Taniguchi H, Akasu T, Fujita S, Yamamoto S, Moriya Y. Clinicopathological significance of fibrous tissue around fixed recurrent rectal cancer in the pelvis. Br J Surg, 94:1530-1535, 2007

15. Shimada K, Sano T, Sakamoto Y, Esaki M, Kosuge T, Ojima H. Clinical impact of the surgical margin status in hepatectomy for solitary mass-forming type intrahepatic cholangiocarcinoma without lymph node metastases. J Surg Oncol, 96:160-165, 2007

16. Shimada K, Sano T, Sakamoto Y, Esaki M, Kosuge T, Ojima H. Surgical outcomes of the mass-forming plus periductal infiltrating types of intrahepatic cholangiocarcinoma: a comparative study with the typical mass-forming type of intrahepatic cholangiocarcinoma. World J Surg, 31:2016-2022, 2007

17. Hibi T, Sano T, Sakamoto Y, Takahashi Y, Uemura N, Ojima H, Shimada K, Kosuge T. Surgery for hepatic neuroendocrine tumors: a single institutional experience in Japan. Jpn J Clin Oncol, 37:102-107, 2007

18. Hibi T, Sakamoto Y, Asamura H, Tochigi N, Ojima H, Shimada K, Sano T, Kosuge T. Successful resection of hepatocellular carcinoma with bronchobiliary fistula caused by repeated transcatheter arterial embolizations: Report of a case. Surg Today, 37:154-158, 2007

19. Maeda T, Tateishi U, Hasegawa T, Ojima H, Arai Y, Sugimura K. Primary hepatic angiosarcoma on coregistered FDG PET and CT images. AJR Am J Roentgenol, 188:1615-1617, 2007

20. Takayasu K, Muramatsu Y, Mizuguchi Y, Ojima H. CT Imaging of early hepatocellular carcinoma and the natural outcome of hypoattenuating nodular lesions in chronic liver disease. Oncology, 72 Suppl 1:83-91, 2007

21. Shiozaki H, Fujiwara Y, Hirai T, Matsubara H, Mori M, Nakamura T, Nakanishi Y, Natsugoe S, Noguchi T, Ozawa S, Shimada Y, Udagawa S, Yamana H, Yano M, Yasuda T, Yanagisawa A. Clinical significance of immunohistochemically detected lymph node micrometastasis in patients with histologically node-negative esophageal carcinoma: a multi-institutional study. Esophagus, 4:35-39, 2007

2. Biochemistry Division

22. Tsuchiya N, Ochiai M, Nakashima K, Ubagai T, Sugimura T, Nakagama H. SND1, a component of RNA-induced silencing complex, is up-regulated in human colon cancers and implicated in early stage colon carcinogenesis. Cancer Res, 67:9568-9576, 2007

23. Liu Y-T, Shang D, Akatsuka S, Ohara H, Dutta KK, Mizushima K, Naito Y, Yoshikawa T, Izumiya M, Abe K, Nakagama H, Noguchi N, Toyokuni S. Chronic oxidative stress causes amplification and overexpression of ptprz1 protein tyrosine phosphatase to activate b-catenin pathway. Am J Pathol, 171:1978-1988, 2007

24. Nakanishi M, Tazawa H, Tsuchiya N, Sugimura T, Tanaka T, Nakagama H. Mouse strain differences in inflammatory responses of colonic mucosa induced by dextran sulfate sodium cause differential susceptibility to PhIP-induced large bowel carcinogenesis. Cancer Sci, 98:1157-1163, 2007

25. Imai T, Fukuta K, Hasumura M, Cho Y-M, Ota Y, Takami S, Nakagama H, Hirose M. Significance of inflammation-associated regenerative mucosa characterized by Paneth cell metaplasia and b-catenin accumulation for the onset of colorectal carcinogenesis in rats initiated with 1,2-dimethylhydrazine. Carcinogenesis, 28:2199-2206, 2007

26. Ikeda I, Tomimoto A, Wada K, Fujisawa T, Fujita K, Yonemitsu K, Nozaki Y, Endo H, Takahashi H, Yoneda M, Inamori M, Kubota K, Saito S, Nagashima Y, Nakagama H, Nakajima A. 5-aminosalicylic acid given in the remission stage of colitis suppresses colitis-associated cancer in a mouse colitis model. Clin Cancer Res, 13:6527-6531, 2007

27. Fuku N, Ochiai M, Terada S, Fujimoto E, Nakagama H, Tabata I. Effect of running training on DMH-induced aberrant crypt foci in rat colon. Med Sci Sports Exerc, 39:70-74, 2007

28. Takahashi H, Yoneda K, Tomimoto A, Endo H, Fujisawa T, Iida H, Mawatari H, Nozaki Y, Ikeda T, Akiyama T, Yoneda M, Inamori M, Abe Y, Saito S, Nakajima A, Nakagama H. Life style-related diseases of the digestive system: colorectal cancer as a life style-related disease: from carcinogenesis to medical treatment. J Pharmacol Sci, 105:129-132, 2007

29. Li Q, Dashwood WM, Zhong X, Nakagama H, Dashwood RH. Bcl-2 overexpression in PhIP-induced colon tumors: cloning of the rat Bcl-2 promoter and characterization of a pathway involving b-catenin, c-Myc and E2F1. Oncogene, 26:6194-6202, 2007

30. Motoyama J-PL, Kim-Motoyama H, Kim P, Nakagama H, Miyagawa K, Suzuki K. Identification of dermcidin in human gestational tissue and characterization of its proteolytic activity. Biochem Biophys Res Commun, 357:828-833, 2007

31. Tazawa H, Tsuchiya N, Izumiya M, Nakagama H. Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells. PNAS, 104:15472-15477, 2007

32. Ohyama T, Furukawa A, Miyoshi T, Takada Y, Ohgara S, Hiratsuka K, Imai T, Okano H, Nakagama H, Nagata T, Katahira M. Interactions with RNA/DNA of proteins involved in the regulation of transcription, translation and telomere elongation. Nucleic Acids Symp Ser (Oxf), 51:77-78, 2007

33. Tanaka E, Fukuda H, Nakashima K, Tsuchiya N, Seimiya H, Nakagama H. HnRNP A3 binds to and protects mammalian telomeric repeats in vitro. Biochem Biophys Res Commun, 358:608-614, 2007

34. Fukuda H, Tsuchiya N, Hara-Fujita K, Takagi S, Nagao M, Nakagama H. Induction of abnormal nuclear shapes in two distinct modes by overexpression of serine/threonine protein phosphatase 5 in Hela cells. J Cell Biochem, 101:321-330, 2007

3. Chemotherapy Division and Cancer Proteomics Project

35. Shitashige M, Naishiro Y, Idogawa M, Honda K, Ono M, Hirohashi S, Yamada T. Involvement of splicing factor-1 in b-catenin/T-cell factor-4-mediated gene transactivation and pre-mRNA splicing. Gastroenterology, 132:1039-1054, 2007

36. Shitashige M, Satow R, Honda K, Ono M, Hirohashi S, Yamada T. Increased susceptibility of Sf1^+/- mice to azoxymethane-induced colon tumorigenesis. Cancer Sci, 98:1862-1867, 2007

37. Idogawa M, Masutani M, Shitashige M, Honda K, Tokino T, Shinomura Y, Imai K, Hirohashi S, Yamada T. Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate b-catenin and T-cell factor-4-mediated gene transactivation: possible linkage of DNA damage recognition and Wnt signaling. Cancer Res, 67:911-918, 2007

38. Huang L, Shitashige M, Satow R, Honda K, Ono M, Yun J, Tomida A, Tsuruo T, Hirohashi S, Yamada T. Functional interaction of DNA topoisomerase IIa with the b-catenin and T-cell factor-4 complex. Gastroenterology, 133:1569-1578, 2007

39. Yamamoto S, Tsuda H, Honda K, Kita T, Takano M, Tamai S, Inazawa J, Yamada T, Matsubara O. Actinin-4 expression in ovarian cancer: a novel prognostic indicator independent of clinical stage and histological type. Mod Pathol, 20:1278-1285, 2007

40. Hara T, Honda K, Shitashige M, Ono M, Matsuyama H, Naito K, Hirohashi S, Yamada T. Mass spectrometry analysis of the native protein complex containing actinin-4 in prostate cancer cells. Mol Cell Proteomics, 6:479-491, 2007

41. Ota Y, Takagi Y, Osaka Y, Shinohara M, Hoshino S, Tsuchida A, Aoki T, Honda K, Yamada T. Usefulness of serum protein profiling for prediction of preoperative chemoradiosensitivity of esophageal cancer. Oncol Rep, 18:653-657, 2007

42. Kikuchi S, Honda K, Handa Y, Kato H, Yamashita K, Umaki T, Shitashige M, Ono M, Tsuchida A, Aoki T, Hirohashi S, Yamada T. Serum albumin-associated peptides of patients with uterine endometrial cancer. Cancer Sci, 98:822-829, 2007

43. Iizuka A, Ikarashi Y, Yoshida M, Heike Y, Takeda K, Quinn G, Wakasugi H, Kitagawa M, Takaue Y. Interleulin(IL)-4 promotes T helper type 2-biased natural killer T (NKT) cell expansion, which is regulated by NKT cell-derived interferon-g and IL-4. Immunology, 123:100-107, 2007

44. Yoshida M, Matsui Y, Ikarashi Y, Usui T, Osada H, Wakasugi H. Antiproliferating activity of the mitotic inhibitor pironetin against vindesine- and paclitaxel-resistant human small cell lung cancer H69 Cells. Anticancer Res, 27:729-736, 2007

4. Biology Division

45. Matsumoto S, Iwakawa R, Takahashi K, Kohno T, Nakanishi Y, Matsuno Y, Suzuki K, Nakamoto M, Shimizu EE, Minna JD, Yokota J. Prevalence and specificity of LKB1 genetic alterations in lung cancers. Oncogene, 26:5911-5918, 2007

46. Nagayama K, Kohno T, Sato M, Arai Y, Minna JD, Yokota J. Homozygous deletion scanning of the lung cancer genome at a 100-kb resolution. Genes Chromosomes Cancer, 46:1000-1010, 2007

47. Takahashi K, Kohno T, Matsumoto S, Nakanishi Y, Arai Y, Yamamoto S, Fujiwara T, Tanaka N, Yokota J. Clonal and parallel evolution of primary lung cancers and their metastases revealed by molecular dissection of cancer cells. Clin Cancer Res, 13:111-120, 2007

48. Yokota J, Matsumoto S, Kohno T. Letter to the Editor: comments to the letter by Edmond S. K. Ma et al. Int J Cancer, 120:1832-1833, 2007

49. Takahashi K, Kohno T, Matsumoto S, Nakanishi Y, Arai Y, Fujiwara T, Tanaka N, Yokota J. Clonality and heterogeneity of pulmonary blastoma from the viewpoint of genetic alterations: a case report. Lung Cancer, 57:103-108, 2007

50. Ajima R, Kajiya K, Inoue T, Tani M, Shiraishi-Yamaguchi Y, Maeda M, Segawa T, Furuichi T, Sutoh K, Yokota J. HOMER2 binds MYO18B and enhances its activity to suppress anchorage independent growth. Biochem Biophys Res Commun, 356:851-856, 2007

51. Edakuni N, Ikuta K, Yano S, Nakataki E, Muguruma H, Uehara H, Tani M, Yokota J, Aizawa H, Sone S. Restored expression of the MYO18B gene suppresses orthotopic growth and the production of bloody pleural effusion by human malignant pleural mesothelioma cells in SCID mice. Oncol Res, 16:235-243, 2006

52. Seike M, Yanaihara N, Bowman ED, Zanetti KA, Budhu A, Kumamoto K, Mechanic LE, Matsumoto S, Yokota J, Shibata T, Sugimura H, Gemma A, Kudoh S, Wang XW, Harris CC. Use of a cytokine gene expression signature in lung adenocarcinoma and the surrounding tissue as a prognostic classifier. J Natl Cancer Inst, 99:1257-1269, 2007

53. Ishiyama T, Kano J, Anami Y, Onuki T, Iijima T, Morisita Y, Yokota J, Noguchi M. OCIA domain containing 2 is highly expressed in adenocarcinoma mixed subtype with bronchioloalveolar carcinoma component and is associated with better prognosis. Cancer Sci, 98:50-57, 2007

54. Maekawa T, Shinagawa T, Sano Y, Sakuma T, Nomura S, Nagasaki K, Miki Y, Saito-Ohara F, Inazawa J, Kohno T, Yokota J, Ishii S. Reduced levels of ATF-2 predispose mice to mammary tumors. Mol Cell Biol, 27:1730-1744, 2007

55. Katsura Y, Sasaki S, Sato M, Yamaoka K, Suzukawa K, Nagasawa T, Yokota J, Kohno T. Involvement of Ku80 in microhomology-mediated end joining for DNA double-strand breaks in vivo. DNA Repair, 6:639-648, 2007

5. Cancer Medicine and Biophysics Division

56. Futamura M, Kamino H, Miyamoto Y, Kitamura N, Nakamura Y, Ohnishi S, Masuda Y, Arakawa H. Possible role of semaphorin 3F, a candidate tumor suppressor gene at 3p21.3, in p53-regulated tumor angiogenesis suppression. Cancer Res, 67:1451-1460, 2007

57. Bourdon A, Minai L, Serre V, Jais J-P, Sarzi E, Aubert S, Chretien D, Lonlay P, Paquis-Flucklinger V, Arakawa H, Nakamura Y, Munnich A, Rotig A. Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion. Nat Genet, 39:776-780, 2007

58. Liu Y, Vikis HG, Yi Y, Furamura M, Wang Y, You M. Degradation of lung adenoma susceptibility 1, a major candidate mouse lung tumor modifier, is required for cell cycle progression. Cancer Res, 67:10207-10213, 2007

6. Growth Factor Division

59. Tanaka M, Sasaki K, Kamata R, Sakai R. The C-terminus of ephrin-B1 regulates metalloproteinase secretion and invasion of cancer cells. J Cell Sci, 120:2179-2189, 2007

60. Tanaka M, Kamata R, Takigahira M, Yanagihara K, Sakai R. Phosphorylation of ephrin-B1 regulates dissemination of gastric scirrhous carcinoma. Am J Pathol, 171:68-78, 2007

61. Uekita T, Jia L, Narisawa-Saito M, Yokota J, Kiyono T, Sakai R. CUB domain-containing protein 1 is a novel regulator of anoikis resistance in lung adenocarcinoma. Mol Cell Biol, 27:7649-7660, 2007

62. Gotoh I, Uekita T, Seiki M. Regulated nucleo-cytoplasmic shuttling of human aci-reductone dioxgenase (hADI1) and its potential role in mRNA processing. Genes to Cells, 12:105-117, 2007

7. Molecular Oncology Division

63. Yoshida H, Ichikawa H, Tagata Y, Katsumoto T, Ohnishi K, Akao Y, Naoe T, Pandolfi PP, Kitabayashi I. PML-retinoic acid receptor a inhibits PML IV enhancement of PU.1-induced C/EBPe expression in myeloid differentiation. Mol Cell Biol, 27:5819-5834, 2007

64. Li X-L, Arai Y, Harada H, Shima Y, Yoshida H, Rokudai S, Aikawa Y, Kimura A, Kitabayashi I. Mutations of the HIPK2 gene in acute myeloid leukemia and myelodysplastic syndrome impair AML1- and p53-mediated transcription. Oncogene, 26:7231-7239, 2007

65. Nakamura Y, Yamagata T, Maki K, Sasaki K, Kitabayashi I, Mitani K. TEL/ETV6 binds to corepressor KAP1 via the HLH domain. Int J Hematol, 84:377-380, 2006

8. Virology Division

66. Narisawa-Saito M, Kiyono T. Basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: roles of E6 and E7 proteins. Cancer Sci, 98:1505-1511, 2007

67. Handa K, Yugawa T, Narisawa-Saito M, Ohno S, Fujita M, Kiyono T. E6AP-dependent degradation of DLG4/PSD95 by high-risk human papillomavirus type 18 E6 protein. J Virol, 81:1379-1389, 2007

68. Narisawa-Saito M, Handa K, Yugawa T, Ohno S, Fujita M, Kiyono T. HPV16 E6-mediated stabilization of ErbB2 in neoplastic transformation of human cervical keratinocytes. Oncogene, 26:2988-2996, 2007

69. Yugawa T, Handa K, Narisawa-Saito M, Ohno S, Fujita M, Kiyono T. Regulation of Notch1 gene expression by p53 in epithelial cells. Mol Cell Biol, 27:3732-3742, 2007

70. Morishima S, Akatsuka Y, Nawa A, Kondo E, Kiyono T, Torikai H, Nakanishi T, Ito Y, Taujimura K, Iwata K, Ito K, Kodera Y, Morishima Y, Kuzushima K, Takahashi T. Identification of an HLA-A24-restricted cytotoxic T lymphocyte epitope from human papillomavirus type-16 E6: the combined effects of bortezomib and interferon-g on the presentation of a cryptic epitope. Int J Cancer, 120:594-604, 2007

71. Kiyono T. Molecular mechanisms of cellular senescence and immortalization of human cells. Expert Opin Biol Ther, 11:1623-1637, 2007

72. Haga K, Ohno S, Yugawa T, Narisawa-Saito M, Fujita M, Sakamoto M, Galloway DA, Kiyono T. Efficient immortalization of primary human cells by p16^INK4a-specific short hairpin RNA or Bmi-1, combined with introduction of hTERT. Cancer Sci, 98:147-154, 2007

73. Yokoi T, Saito M, Kiyono T, Iseki S, Kosaka K, Nishida E, Tsubakimoto T, Harada H, Eto K, Noguchi T, Teranaka T. Establishment of immortalized dental follicle cells for generating periodontal ligament in vivo. Cell Tissue Res, 327:301-311, 2007

74. Ito Y, Kawamorita M, Yamabe T, Kiyono T, Miyamoto K. Chemically fixed nurse cells for culturing murine or primate embryonic stem cells. J Biosci Bioeng, 103:113-121, 2007

75. Cui C-H, Uyama T, Miyado K, Terai M, Kyo S, Kiyono T, Umezawa A. Menstrual blood-derived cells confer human dystrophin expression in the murine model of Duchenne muscular dystrophy via cell fusion and myogenic transdifferentiation. Mol Biol Cell, 18:1586-1594, 2007

76. Shima Y, Okamoto T, Aoyama T, Yasura K, Ishibe T, Nishijo K, Shibata KR, Kohno Y, Fukiage K, Otsuka S, Uejima D, Nakayama T, Nakamura T, Kiyono T, Toguchida J. In vitro transformation of mesenchymal stem cells by oncogenic H-rasVal12. Biochem Biophys Res Commun. 353:60-66, 2007

9. Genetics Division

77. Mori K, Suzuki T, Uozaki H, Nakanishi H, Ueda T, Matsuno Y, Kodera Y, Sakamoto H, Yamamoto N, Sasako M, Kaminishi M, Sasaki H. Detection of minimal gastric cancer cells in peritoneal washings by focused microarray analysis with multiple markers: clinical implications. Ann Surg Oncol, 14:1694-1702, 2007

78. Yajima S, Ishii M, Matsushita H, Aoyagi K, Yoshimatsu K, Kaneko H, Yamamoto N, Teramoto T, Yoshida T, Matsumura Y, Sasaki H. Expression profiling of fecal colonocytes for RNA-based screening of colorectal cancer. Int J Oncol, 31:1029-1037, 2007

79. Saeki N, Kim DH, Usui T, Aoyagi K, Tatsuta T, Aoki K, Yanagihara K, Tamura M, Mizushima H, Sakamoto H, Ogawa K, Ohki M, Shiroishi T, Yoshida T, Sasaki H. GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-b-dependent apoptotic signalling. Oncogene, 26:6488-6498, 2007

80. Ishida M, Miyamoto M, Naitoh S, Tatsuda D, Hasegawa T, Nemoto T, Yokozeki H, Nishioka K, Matsukage A, Ohki M, Ohta T. The SYT-SSX fusion protein down-regulates the cell proliferation regulator COM1 in t(x;18) synovial sarcoma. Mol Cell Biol, 27:1348-1355, 2007

81. Maekawa K, Saeki M, Saito Y, Ozawa S, Kurose K, Kaniwa N, Kawamoto M, Kamatani N, Kato K, Hamaguchi T, Yamada Y, Shirao K, Shimada Y, Muto M, Doi T, Ohtsu A, Yoshida T, Matsumura Y, Saijo N, Sawada J. Genetic variations and haplotype structures of the DPYD gene encoding dihydropyrimidine dehydrogenase in Japanese and their ethnic differences. J Hum Genet, 52:804-819, 2007

82. Kim SR, Sai K, Tanaka-Kagawa T, Junno H, Ozawa S, Kaniwa N, Saito Y, Akasawa A, Matsumoto K, Saito H, Kamatani N, Shirao K, Yamamoto N, Yoshida T, Minami H, Ohtsu A, Saijo N, Sawada J. Haplotypes and a novel defective allele of CES2 found in a Japanese population. Drug Metabolism and Disposition 35:1865-1872, 2007

83. Saito Y, Katori N, Soyama A, Nakajima Y, Yoshitani T, Kim S, Fukushima-Uesaka H, Kurose K, Kaniwa N, Ozawa S, Kamatani N, Komamura K, Kamakura S, Kitakaze M, Tomoike H, Sugai K, Minami N, Kimura H, Goto Y, Minami H, Yoshida T, Kunitoh H, Ohe Y, Yamamoto N, Tamura T, Saijo N, Sawada J. CYP2C8 haplotype structures and their influence on pharmacokinetics of paclitaxel in a Japanese population. Pharmacogenetics and Genomics, 17:461-471, 2007

84. Kim SR, Saito Y, Sai K, Kurose K, Maekawa K, Kaniwa N, Ozawa S, Kamatani N, Shirao K, Yamamoto N, Hamaguchi T, Kunitoh H, Ohe Y, Yamada Y, Tamura T, Yoshida T, Minami H, Ohtsu A, Saijo N, Sawada J. Genetic variations and frequencies of major haplotypes in SLCO1B1 encoding the transporter OATP1B1 in Japanese subjects: SLCO1B1*17 is more prevalent than *15. Drug Metab Pharmacokinet, 22:456-461, 2007

85. Ukaji M, Saito Y, Fukushima-Uesaka H, Maekawa K, Katori N, Kaniwa N, Yoshida T, Nokihara H, Sekine I, Kunitoh H, Ohe Y, Yamamoto N, Tamura T, Saijo N, Sawada J. Genetic variations of VDR/NR1I1 encoding vitamin D receptor in a Japanese population. Drug Metab Pharmacokinet, 22:462-467, 2007

86. Katoh M, Katoh M. WNT signaling pathway and stem cell signaling network. Clin Cancer Res, 13:4042-4045, 2007

87. Katoh M. Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis. Stem Cells Rev, 3:30-38, 2007

88. Katoh M, Katoh M. Comparative integromics on non-canonical WNT or planar cell polarity signaling molecules: transcriptional mechanism of PTK7 in colorectal cancer and that of SEMA6A in undifferentiated ES cells. Int J Mol Med, 20:405-409, 2007

89. Katoh M, Katoh M. Integrative genomic analyses on HES/HEY family: notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer. Int J Oncol, 31:461-466, 2007

90. Katoh M, Katoh M. Notch signaling in gastrointestinal tract (review). Int J Oncol, 30:247-251, 2007

91. Katoh M, Katoh M. Conserved POU/OCT- and GATA-binding sites in 5'-flanking promoter region of mammalian WNT8B orthologs. Int J Oncol, 30:1273-1277, 2007

92. Katoh Y, Katoh M. Conserved POU-binding site linked to SP1-binding site within FZD5 promoter: transcriptional mechanisms of FZD5 in undifferentiated human ES cells, fetal liver/spleen, adult colon, pancreatic islet, and diffuse-type gastric cance. Int J Oncol, 30:751-755, 2007

93. Katoh M, Katoh M. Comparative integromics on JMJD1C gene encoding histone demethylase: conserved POU5F1 binding site elucidating mechanism of JMJD1C expression in undifferentiated ES cells and diffuse-type gastric cance. Int J Oncol, 31:219-223, 2007

94. Katoh Y, Katoh M. Comparative integromics on JMJD2A, JMJD2B and JMJD2C: preferential expression of JMJD2C in undifferentiated ES cell. Int J Mol Med, 20:269-273, 2007

95. Katoh M. Dysregulation of stem cell signaling network due to germline mutation, SNP, Helicobacter pylori infection, epigenetic change and genetic alteration in gastric cancer. Cancer Biol Ther, 6:832-839, 2007

96. Zhang J, Hosoya T, Maruyama A, Nishikawa K, Maher JM, Ohta T, Motohashi H, Fukamizu A, Shibahara S, Itoh K, Yamamoto M. Nrf2 Neh5 domain is differentially utilized in the transactivation of cytoprotective genes. Biochem J, 404:459-466, 2007

97. Kimura H, Suminioe M, Kasahara K, Sone T, Araya T, Tamori S, Koizumi F, Nishio K, Miyamoto K, Fujimura M, Nakao S. Evaluation of epidermal growth factor receptor mutation status in serum DNA as a predictor of response to gefitinib (IRESSA). Br J Cancer, 97:778-784, 2007

98. Furuhata S, Ando K, Oki M, Aoki K, Ohnishi S, Aoyagi K, Sasaki H, Sakamoto H, Yoshida T and Ohnami S. Gene expression profiles of endothelial progenitor cells by oligonucleotide microarray analysis. Mol and Cell Biochem, 298:125-138, 2007

99. Hirakawa A, Sato Y, Sozu T, Hamada C, Yoshimura I. Estimating the False Discovery Rate Using Mixed Normal Distribution for Identifying Differentially Expressed Genes in Microarray Data Analysis. Cancer Informatics, 3:367-375, 2007

10. Radiobiology Division and Cancer and Cell Cycle Project

100. Inoue Y, Kitagawa M, Taya Y. Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage. EMBO J, 26:2083-2093, 2007

101. Junttila MR, Puustinen P, Niemela M, Ahola R, Arnold H, Bottzauw T, Ala-aho R, Nielsen C, Ivaska J, Taya Y, Lu S-L, Lin S, Chan EK, Wang X-J, Grenman R, Kast J, Kallunki T, Sears R, Kahari V-M, Westermarck J. CIP2A inhibits PP2A in human malignancies. Cell, 130:51-62, 2007

102. Ohki R, Kawase T, Ohta T, Ichikawa H, Taya Y. Dissecting functional roles of p53 N-terminal transactivation domains by microarray expression analysis. Cancer Sci, 98:189-200, 2007

103. Benosman S, Gross I, Clarke N, Jochemsen AG, Okamoto K, Loeffler J-P, Gaiddon C. Multiple neurotoxic stresses converge on MDMX proteolysis to cause neuronal apoptosis. Cell Death Differ, 14:2047-2057, 2007

11. Carcinogenesis Division

104. Ushijima T. Epigenetic field for cancerization. J Biochem Mol Biol, 40:142-150, 2007

105. Enomoto S, Maekita T, Tsukamoto T, Nakajima T, Nakazawa K, Tatematsu M, Ichinose M, Ushijima T. Lack of association between CpG island methlator phenotype in human gastric cancers and methylation in their background non-cancerous gastric mucosae. Cancer Sci, 98:1853-1861, 2007

106. Abe M, Westermann F, Nakagawara A, Takato T, Schwab M, Ushijima T. Marked and independent prognostic significance of the CpG island methylator phenotype in neuroblastoma. Cancer Lett, 247:253-258, 2007

107. Nobeyama Y, Okochi-Takada E, Furuta J, Miyagi Y, Kikuchi K, Yamamoto A, Nakanishi Y, Nakagawa H, Ushijima T. Silencing of tissue factor pathway inhibitor-2 gene in malignant melanomas. Int J Cancer, 121:301-307, 2007

108. Cai L-y, Abe M, Izumi S, Imura M, Yasugi T, Ushijima T. Identification of PRTFDC1 silencing and aberrant promoter methylation of GPR150, ITGA8 and HOXD11 in ovarian cancers. Life Sci, 80:1458-1465, 2007

109. Moriguchi K, Yamashita S, Tsujino Y, Tatematsu M, Ushijima T. Larger numbers of silenced genes in cancer cell lines with increased de novo methylation of scattered CpG sites. Cancer Lett, 249:178-187, 2007

110. Hsu C-H, Stedeford T, Okochi-Takada E, Ushijima T, Noguchi H, Muro-Cacho C, Holder JW, Banasik M. Framework analysis for the carcinogenic mode of action of nitrobenzene. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev, 25:155-184, 2007

111. Takasu S, Tsukamoto T, Ushijima T, Yamashita S, Ogasawara N, Ban H, Yanai T, Masegi T, Tatematsu M. Cyclin D1 overexpression in N-methyl-N'-nitrosoguanidine-induced rat gastric adenocarcinomas. Exp Toxicol Pathol, 59:171-175, 2007

12. Section for Studies on Metastasis

112. Ochiya T, Honma K, Takeshita F, Nagahara S. Atelocollagen-mediated drug discovery technology. Expert Opin Drug Discov, 2:159-167, 2007

113. Morita S, Horii T, Kimura M, Goto Y, Ochiya T, Hatada I. One Argonaute family member, Eif2c2 (Ago2), is essential for development and appears not to be involved in DNA methylation. Genomics, 89:687-696, 2007

114. Watanabe H, Ochiya T, Ueda S, Kominami Y, Gon R, Nishiki M, Hayashi M, Sasaki A, Shiraishi M, Kashimoto N, Myojin Y, Kamiya K. Differentiation of a hepatic phenotype after heterotropic transplantation of heart, kidney, brain, and skin tissues into liver in F344 rats. Biochem Biophys Res Commun, 354:841-845, 2007

115. Banas A, Yamamoto Y, Teratani T, Ochiya T. Stem cell plasticity: learning from hepatogenic differentiation strategies. Dev Dyn, 236:3228-3241, 2007

116. Yamamoto Y, Banas, A, Kato T, Ochiya T. Plasticity of adult stem cells into liver. Curr Res in Hepatology, 1:1-18, 2007

117. Banas A, Teratani T, Yamamoto Y, Tokuhara M, Takeshita F, Quinn G, Okochi H, Ochiya T. Adipose tissue-derived mesenchymal stem cells as a source of human hepatocytes. Hepatology, 46:219-228, 2007

118. Honma K, Miyata T, Ochiya T. Type I collagen gene suppresses tumor growth and invasion of malignant human glioma cells. Cancer Cell Int, 7:12, 2007

13. Section for Studies on Host-Immune Response

119. Hara H, Kobayashi A, Yoshida K, Ohashi M, Ohnami S, Uchida E, Higashihara E, Yoshida T, Aoki K. Local interferon-a gene therapy elicits systemic immunity in a syngeneic pancreatic cancer model in hamster. Cancer Sci, 98:455-463, 2007

120. Kobayashi A, Hara H, Ohashi M, Nishimoto T, Yoshida K, Ohkohchi N, Yoshdia T, Aoki K. Allogeneic MHC gene transfer enhances an effective antitumor immunity in the early period of autologous hematopoietic stem cell transplantation. Clin Cancer Res, 13:7469-7479, 2007

121. Miura Y, Yoshida K, Nishimoto T, Hatanaka K, Ohnami S, Asaka M, Douglas JT, Curiel DT, Yoshida T, Aoki K. Direct selection of targeted adenovirus vectors by random peptide display on the fiber knob. Gene Ther, 14:1448-1460, 2007

14. ADP-Ribosylation in Oncology Project

122. Sugo N, Niimi N, Aratani Y, Masutani M, Suzuki H, Koyama H. Decreased PARP-1 levels accelerate embryonic lethality but attenuate neuronal apoptosis in DNA polymerase b-deficient mice. Biochem Biophys Res Commun, 354:656-661, 2007

123. Miwa M, Masutani M. PolyADP-ribosylation and cancer. Cancer Sci, 98:1528-1535, 2007

124. Ogino H, Nozaki T, Gunji A, Maeda M, Suzuki H, Ohta T, Murakami Y, Nakagama H, Sugimura T, Masutani M. Loss of Parp-1 affects gene expression profile in a genome-wide manner in ES cells and liver cells. BMC Genomics, 8:41 (1-16), 2007

125. Shirato M, Tozawa S, Maeda D, Watanabe M, Nakagama H, Masutani M. Poly(etheno ADP-ribose) blocks poly(ADP-ribose) glycohydrolase activity. Biochem Biophys Res Commun, 355:451-456, 2007

15. Cancer Genomics Project

126. Katoh H, Ojima H, Kokubu A, Saito S, Kondo T, Kosuge T, Hosoda F, Imoto I, Inazawa J, Hirohashi S, Shibata T. Genetically distinct and clinically relevant classification of hepatocellular carcinoma: putative therapeutic targets. Gastroenterology, 133:1475-1486, 2007

127. Shibata T, Hanada S, Kokubu A, Matsuno Y, Asamura H, Ohta T, Sakamoto M, Hirohashi S. Gene expression profiling of epidermal growth factor receptor/KRAS pathway activation in lung adenocarcinoma. Cancer Sci, 98:985-991, 2007

128. Yoshikawa D, Ojima H, Iwasaki M, Hiraoka N, Kosuge T, Kasai S, Hirohashi S, Shibata T. Clinicopathological and prognostic significance of EGFR, VEGF, and HER2 expression in cholangiocarcinoma. Br J Cancer, 98:418-425, 2007

129. Loukopoulos P, Shibata T, Katoh H, Kokubu A, Sakamoto M, Yamazaki K, Kosuge T, Kanai Y, Hosoda F, Imoto I, Ohki M, Inazawa J, Hirohashi S. Genome-wide array-based comparative genomic hybridization analysis of pancreatic adenocarcinoma: identification of genetic indicators that predict patient outcome. Cancer Sci, 98:392-400, 2007

16. Cancer Prevention Basic Research Project

130. Nishigaki R, Totsuka Y, Kataoka H, Ushiyama H, Goto S, Akasu T, Watanabe T, Sugimura T, Wakabayashi K. Detection of aminophenylnorharman, a possible endogenous mutagenic and carcinogenic compound, in human urine samples. Cancer Epidemiol Biomarkers Prev, 16:151-156, 2007

131. Totsuka Y, Nishigaki R, Takamura-Enya T, Kawahara N, Sugimura T, Wakabayashi K. Analysis of the major RNA adduct derived from aminophenylnorharman, a novel endogenous mutagen and carcinogen. Genes Environ, 29:54-62, 2007

132. Kohno H, Totsuka Y, Yasui Y, Suzuki R, Sugie S, Wakabayashi K, Tanaka T. Tumor-initiating potency of a novel heterocyclic amine, aminophenylnorharman in mouse colonic carcinogenesis model. Int J Cancer, 121:1659-1664, 2007

133. Mizuno T, Takamura-Enya T, Watanabe T, Hasei T, Wakabayashi K, Ohe T. Quantification of a potent mutagenic 4-amino-3,3'-dichloro-5,4'-dinitrobiphenyl (ADDB) and the related chemicals in water from the Waka River in Wakayama, Japan. Mutat Res, 630:112-121, 2007

134. Hino O, Wakabayashi K, Tatematsu M, Tajima K. 'On environmental carcinogens: from an era of risk evaluation to an era of risk management' Tokyo, Japan, 29 July 2006. Cancer Sci, 98:617-619, 2007

135. Busquets R, Puignou L, Galceran M T, Wakabayashi K, Skog K. Liquid chromatography-tandem mass spectrometry analysis of 2-amino-1-methyl-6-(4-hydroxyphenyl)imidazo[4,5-b]pyridine in cooked meats. J Agric Food Chem, 55:9318-9324, 2007

136. Nakae D, Ogata A, Uehara S, Takahashi S, Totsuka Y, Takahashi M, Wakabayashi K. Assessment of carcinogenic risks of chemicals applicable for cancer high-risk groups. Organohalogen Compounds, 79:1821-1824, 2007

137. Kohno H, Takahashi M, Yasui Y, Suzuki R, Miyamoto S, Kamanaka Y, Naka M, Maruyama T, Wakabayashi K, Tanaka T. A specific inducible nitric oxide synthase inhibitor, ONO-1714 attenuates inflammation-related large bowel carcinogenesis in male Apc^Min/+ mice. Int J Cancer, 121:506-513, 2007

138. Niho N, Mutoh M, Komiya M, Ohta T, Sugimura T, Wakabayashi K. Improvement of hyperlipidemia by indomethacin in Min mice. Int J Cancer, 121:1665-1669, 2007

139. Takeuchi Y, Takahashi M, Sakano K, Mutoh M, Niho N, Yamamoto M, Sato H, Sugimura T, Wakabayashi K. Suppression of N-nitrosobis(2-oxopropyl)amine-induced pancreatic carcinogenesis in hamsters by pioglitazone, a ligand of peroxisome proliferator-activated receptor g. Carcinogenesis, 28:1692-1696, 2007

140. Sakano K, Takahashi M, Mutoh M, Niho N, Komiya M, Sato H, Tanaka T, Sugimura T, Wakabayashi K. Enhanced thyroid carcinogenicity of N-nitrosobis(2-oxopropyl)amine in Otsuka Long-Evans Tokushima Fatty rats, a model of type II diabetes mellitus. Carcinogenesis, 28:2193-2198, 2007

141. Taniguchi K, Kakinuma S, Tokairin Y, Arai M, Kohno H, Wakabayashi K, Imaoka T, Ito E, Koike M, Uetake H, Nishimura M, Yamauchi K, Sugihara K, Shimada Y. Mild inflammation accelerates colon carcinogenesis in Mlh1-deficient mice. Oncology, 71:124-130, 2006

142. Tsuda H, Iigo M, Takasuka N, Ueda S, Ohshima Y, Fukamachi K, Shirai T, Hirano S, Matsuda E, Wakabayashi K. Possible enhancing activity of diacylglycerol on 4-nitroquinoline 1-oxide induced carcinogenesis of the tongue in human c-Ha-ras proto-oncogene transgenic rats. Food Chem Toxicol, 45:1013-1019, 2007

143. Makita H, Mutoh M, Maruyama T, Yonemoto K, Kobayashi A, Fujitsuka H, Toida M, Shibata T, Miyamoto S, Yasui Y, Suzuki R, Wakabayashi K, Tanaka T. A prostaglandin E₂ receptor subtype EP₁-selective antagonist, ONO-8711, suppresses 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis. Carcinogenesis, 28:677-684, 2007

144. Kohno H, Suzuki R, Yasui Y, Miyamoto S, Wakabayashi K, Tanaka T. Ursodeoxycholic acid versus Sulfasalazine in colitis-related colon carcinogenesis in mice. Clin Cancer Res, 13:2519-2525, 2007

145. Matsumoto Y, Matsushima-Hibiya Y, Nakano T, Yamamoto M, Iwabuchi K, Sugimura T, Wakabayashi K. Persistence of pierisin-1 activities in the adult cabbage white butterfly, Pieris rapae, during storage after killing. Proc Jpn Acad Ser B, 83:175-178, 2007

146. Kawanishi M, Matsukawa K, Kuraoka I, Takamura-Enya T, Totsuka Y, Matsumoto Y, Watanabe M, Zou Y, Tanaka K, Sugimura T, Wakabayashi K, Yagi T. Molecular evidence of the involvement of the nucleotide excision repair (NER) system in the repair of the mono(ADP-ribosyl)ated DNA adduct produced by pierisin-1, an apoptosis-inducing protein from the cabbage butterfly. Chem Res Toxicol, 20:694-700, 2007

147. Kawanishi M, Matsukawa K, Ohashi E, Takamura T, Totsuka Y, Watanabe M, Sugimura T, Wakabayashi K, Hanaoka F, Ohmori H, Yagi T. Translesion DNA synthesis across mono ADP-ribosylated deoxyguanosine by Y-family DNA polymerases. In: Valon CL (ed), New Developments in Mutation Research. USA, Nova Science Publishers, Inc., pp 133-148, 2007

17. Cancer Transcriptome Project

148. Shimada A, Ichikawa H, Taki T, Kubota C, Hongo T, Sako M, Morimoto A, Tawa A, Tsukimoto I, Hayashi Y. Low frequency of KIT gene mutation in pediatric acute myeloid leukemia with inv(16)(p13q22): a study of the Japanese Childhood AML Cooperative Study Group. Int J Hematol, 86:289-290, 2007

149. Nakayama R, Nemoto T, Takahashi H, Ohta T, Kawai A, Seki K, Yoshida T, Toyama Y, Ichikawa H, Hasegawa T. Gene expression analysis of soft tissue sarcomas: characterization and reclassification of malignant fibrous histiocytoma. Mod Pathol, 20:749-759, 2007

150. Shen Y, Khusial RP, Li X, Ichikawa H, Moreno AP, Goldberg GS. Src utilizes Cas to block gap junctional communication mediated by connexin43. J Biol Chem, 282:18914-18921, 2007

18. Proteome Bioinformatics Project

151. Yokoo H, Kondo T, Okano T, Nakanishi K, Sakamoto M, Kosuge T, Todo S, Hirohashi S. Protein expression associated with early intrahepatic recurrence of hepatocellular carcinoma after curative surgery. Cancer Sci, 98:665-673, 2007

152. Okano T, Kondo T, Fujii K, Nishimura T, Takano T, Ohe Y, Tsuta K, Matsuno Y, Gemma A, Kato H, Kudoh S, Hirohashi S. Proteomic signature corresponding to the response to gefitinib (Iressa, ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor in lung adenocarcinoma. Clin Cancer Res, 13:799-805, 2007

153. Kakisaka T, Kondo T, Okano T, Fujii K, Honda K, Endo M, Tsuchida A, Aoki T, Itoi T, Moriyasu F, Yamada T, Kato H, Nishimura T, Todo S, Hirohashi S. Plasma proteomics of pancreatic cancer patients by multi-dimensional liquid chromatography and two-dimensional difference gel electrophoresis (2D-DIGE): up-regulation of leucine-rich alpha-2-glycoprotein in pancreatic cancer. J Chromatogr B, 852:257-267, 2007

154. Kondo T, Hirohashi S. Application of highly sensitive fluorescent dyes (CyDye DIGE Fluor saturation dyes) to laser microdissection and two-dimensional difference gel electrophoresis (2D-DIGE) for cancer proteomics. Nature Protocols, 1:2940-2956, 2006

19. Tumor Endocrinology Project

155. Ono M, Yaguchi H, Ohkura N, Kitabayashi I, Nagamura Y, Nomura T, Miyachi Y, Tsukada T, Sakaguchi S. Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1. Nature, 446:685-689, 2007

20. Epidemiology and Prevention Division

156. Lee K-J, Inoue M, Otani T, Iwasaki M, Sasazuki S, Tsugane S, for the JPHC Study Group. Physical activity and risk of colorectal cancer in Japanese men and women: the Japan Public Health Center-based prospective Study. Cancer Causes Control, 18:199-209, 2007

157. Ishihara J, Otani T, Inoue M, Iwasaki M, Sasazuki S, Shoichiro T, for the Japan Public Health Center-based Prospective Study Group. Low intake of vitamin B-6 is associated with increased risk of colorectal cancer in Japanese men. J Nutr, 137:1808-1814, 2007

158. Lee K-J, Inoue M, Otani T, Iwasaki M, Sasazuki S, Tsugane S, for the JPHC Study Group. Coffee consumption and risk of colorectal cancer in a population-based prospective cohort of Japanese men and women. Int J Cancer, 121:1312-1318, 2007

159. Lee K-J, Inoue M, Otani T, Iwasaki M, Sasazuki S, Tsugane S, the Japan Public Health Center-based Prospective Study Group. Colorectal cancer screening using fecal occult blood test and subsequent risk of colorectal cancer: a prospective cohort study in Japan. Cancer Detect Prev, 31:3-11, 2007

160. Luo J, Iwasaki M, Inoue M, Sasazuki S, Otani T, Ye W, Tsugane S, for the JPHC Study Group. Body mass index, physical activity and the risk of pancreatic cancer in relation to smoking status and history of diabetes: a large-scale population-based cohort study in Japan-The JPHC study. Cancer Causes Control, 18:603-612, 2007

161. Luo J, Inoue M, Iwasaki M, Sasazuki S, Otani T, Ye W, Tsugane S; Japan Public Health Center-based Prospective Study Group. Green tea and coffee intake and risk of pancreatic cancer in a large-scale population-based cohort study in Japan (JPHC study). Eur J Cancer Prev, 16:542-548, 2007

162. Iwasaki M, Otani T, Inoue M, Sasazuki S, Tsugane S, for the Japan Public Health Center-based Prospective Study Group. Body size and risk for breast cancer in relation to estrogen and progesterone receptor status in Japan. Ann Epidemiol, 17:304-312, 2007

163. Iwasaki M, Otani T, Inoue M, Sasazuki S, Tsugane S, for the Japan Public Health Center-based Prospective Study Group. Role and impact of menstrual and reproductive factors on breast cancer risk in Japan. Eur J Cancer Prev, 16:116-123, 2007

164. Kurahashi N, Iwasaki M, Sasazuki S, Otani T, Inoue M, Tsugane S, the Japan Public Health Center-based Prospective Study Group. Soy product and isoflavone consumption in relation to prostate cancer in Japanese men. Cancer Epidemiol Biomarkers Prev, 16:538-545, 2007

165. Kurahashi N, Iwasaki M, Sasazuki S, Otani T, Inoue M, Tsugane S. Soy isoflavone consumption is not associated with increased risk of advanced prostate cancer. Cancer Epidemiol Biomarkers Prev, 16:2169, 2007

166. Nakamura Y, Kita Y, Iso H, Ueshima H, Okada K, Konishi M, Inoue M, Tsugane S, The JPHC Study Group. Alcohol consumption, alcohol-induced flushing and incidence of acute myocardial infarction among middle-aged men in Japan-Japan Public Health Center-based prospective study. Atherosclerosis, 194:512-516, 2007

167. Kokubo Y, Iso H, Ishihara J, Okada K, Inoue M, Tsugane S, for the JPHC Study Group. Association of dietary intake of soy, beans and isoflavones with risk of cerebral center-based (JPHC) Study Cohort I. Circulation, 116:2553-2562, 2007

168. Yoshida M, Takashima Y, Inoue M, Iwasaki M, Otani T, Sasaki S, Tsugane S, for the JPHC Study Group. Prospective study showing that dietary vitamin C reduced the risk of age-related cataracts in a middle-aged Japanese population. Eur J Nutr, 46:118-124, 2007

169. Otani T, Iwasaki M, Sasazuki S, Inoue M, Tsugane S, the Japan Public Health Center-based Prospective Study Group. Plasma C-peptide, insulin-like growth factor-I, insulin-like growth factor binding proteins and risk of colorectal cancer in a nested case-control study: the Japan public health center-based prospective study. Int J Cancer, 120:2007-2012, 2007

170. Otani T, Iwasaki M, Sasazuki S, Inoue M, Tsugane S. Plasma vitamin D and risk of colorectal cancer: the Japan Public Health Center-Based Prospective Study. Br J Cancer, 97:446-451, 2007

171. Inoue M, Wakai K, Nagata C, Mizoue T, Tanaka K, Tsuji I, Tsugane S, for the Research group for the Development and Evaluation of Cancer Prevention. Alcohol drinking and total cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population. Jpn J Clin Oncol, 37:692-700, 2007

172. Wakai K, Nagata C, Mizoue T, Tanaka K, Nishino Y, Tsuji I, Inoue M, Tsugane S, for the Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan. Alcohol drinking and lung cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population. Jpn J Clin Oncol, 37:168-174, 2007

173. Nagata C, Mizoue T, Tanaka K, Tsuji I, Wakai K, Inoue M, Tsugane S, for the Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan. Alcohol drinking and breast cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population. Jpn J Clin Oncol, 37:568-574, 2007

174. Tsuchiya M, Tsukino H, Iwasaki M, Sasaki H, Tanaka T, Katoh T, Patterson DG Jr, Turner W, Needham L, Tsugane S. Interaction between cytochrome P450 gene polymorphisms and serum organochlorine TEQ levels in the risk of endometriosis.Mol Hum Reprod, 13:399-404, 2007

175. Tsuchiya M, Miura T, Hanaoka T, Iwasaki M, Sasaki H, Tanaka T, Nakao H, Katoh T, Ikenoue T, Kabuto M, Tsugane S. Effect of soy isoflavones on endometriosis: interaction with estrogen receptor 2 gene polymorphism. Epidemiology, 18:402-408, 2007

176. Itoh H, Iwasaki M, Hanaoka T, Sasaki H, Tanaka T and Tsugane S. Urinary Bisphenol-A Concentration in Infertile Japanese Women and Its Association with Endometriosis: A Cross-Sectional Study. Environmental Health and Preventive Medicine, 2:258-264, 2007

177. Tsuchiya M, Iwasaki M, Otani T, Nitadori J, Goto K, Nishiwaki Y, Uchitomi Y, Tsugane S. Breast cancer in first-degree relatives and risk of lung cancer: assessment of the existence of gene sex interactions. Jpn J Clin Oncol, 37:419-423, 2007

178. Minegishi Y, Tsukino H, Muto M, Goto K, Gemma A, Tsugane S, Kudoh S, Nishiwaki Y, Esumi H. Susceptibility to lung cancer and genetic polymorphisms in the alcohol metabolite-related enzymes alcohol dehydrogenase 3, aldehyde dehydrogenase 2, and cytochrome P450 2E1 in the Japanese population. Cancer, 110:353-362, 2007

179. Machida-Montani A, Sasazuki S, Inoue M, Natsukawa S, Shaura K, Koizumi Y, Kasuga Y, Hanaoka T, Tsugane S. Atrophic gastritis, Helicobacter pylori, and colorectal cancer risk: a case-control study. Helicobacter, 12:328-332, 2007

180. Yamada H, Shinmura K, Ikeda S, Tao H, Otani T, Hanaoka T, Tsuneyoshi T, Tsugane S, Sugimura H. Association between CDH1 haplotypes and gastric cancer risk in a Japanese population. Scand J Gastroenterol, 42:1479-1485, 2007

181. Kobayashi M, Hanaoka T, Tsugane S. Validity of a self-administered food frequency questionnaire in the assessment of heterocyclic amine intake using 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridin (PhIP) levels in hair. Mutat Res, 630:14-19, 2007

182. Tsugane S, Sasazuki S. Diet and the risk of gastric cancer: review of epidemiological evidence. Gastric Cancer, 10:75-83, 2007

183. Tsugane S. Dietary factors in gastrointestinal tract cancers - an Asian perspective. Acta Oncol, 46:405-406, 2007

184. Yamauchi C, Hasebe T, Iwasaki M, Imoto S, Wada N, Fukayama M, Ochiai A. Accurate assessment of lymph vessel tumor emboli in invasive ductal carcinoma of the breast according to tumor areas, and their prognostic significance. Hum Pathol, 38:247-259, 2007

21. Cancer Information Services and Surveillance Division

185. Marugame T, Matsuda T, Kamo K, Katanoda K, Ajiki W, Sobue T, Japan Cancer Surveillance Research Group. Cancer incidence and incidence rates in Japan in 2001 based on the data from 10 population-based cancer registries. Jpn J Clin Oncol, 37:884-891, 2007

186. Kamo KI, Kaneko S, Satoh K, Yanagihara H, Mizuno S, Sobue T. A mathematical estimation of true cancer incidence using data from population-based cancer registries. Jpn J Clin Oncol, 37:150-155, 2007

187. Marugame T, Katanoda K, Matsuda T, Hirabayashi Y, Kamo K, Ajiki W, Sobue T, Japan Cancer Surveillance Research Group. The Japan cancer surveillance report: incidence of childhood, bone, penis and testis cancers. Jpn J Clin Oncol, 37:319-323, 2007

188. Ioka A, Tsukuma H, Ajiki W, Oshima A. Hospital procedure volume and survival of cancer patients in Osaka, Japan: a population-based study with latest cases. Jpn J Clin Oncol, 37:544-553, 2007

189. Matsuno RK, Anderson WF, Yamamoto S, Tsukuma H, Pfeiffer RM, Kobayashi K, Devesa SS, Levine PH. Early- and late-onset breast cancer types among women in the United States and Japan. Cancer Epidemiol Biomarkers Prev, 16:1437-1442, 2007

190. Hirabayashi Y, Saika K. Comparison of time trends in oesophagus cancer incidence (1973-1997) in East Asia, Europe, and the USA, from Cancer Incidence in Five Continents Vol. IV VIII. Jpn J Clin Oncol, 37:893-895, 2007

191. Hirabayashi Y, Tanaka S. Comparison of time trends in colorectal cancer incidence (1973-97) in East Asia, Europe and USA, from Cancer Incidence in Five Continents Vol. IV-VIII. Jpn J Clin Oncol, 37:325-327, 2007

192. Katanoda K, Marugame T. Comparison of time trends in cancer incidence (1973-1997) in East Asia, Europe and USA, from Cancer Incidence in Five Continents Vol. IV-VIII. Jpn J Clin Oncol, 37:157-159, 2007

193. Katanoda K, Qiu D. Comparison of time trends in female breast cancer incidence (1973-1997) in East Asia, Europe and USA, from Cancer Incidence in Five Continents, Vol. IV VIII. Jpn J Clin Oncol, 37:638-639, 2007

194. Marugame T, Dongmei Q. Comparison of time trends in stomach cancer incidence (1973-1997) in East Asia, Europe and USA, from Cancer Incidence in Five Continents Vol. IV-VIII. Jpn J Clin Oncol, 37:242-243, 2007

195. Marugame T, Hirabayashi Y. Comparison of time trends in ovary cancer incidence (1973-1997) in East Asia, Europe, and the USA, from Cancer Incidence in Five Continents Vol. IV VIII. Jpn J Clin Oncol, 37:802-803, 2007

196. Matsuda T, Saika K. Comparison of time trends in prostate cancer incidence (1973-1997) in East Asia, Europe and USA, from Cancer Incidence in Five Continents Vol. IV VIII. Jpn J Clin Oncol, 37:556-557, 2007

197. Qiu D, Hirabayashi Y. Comparison of time trends in liver cancer incidence (1973-1997) in East Asia, Europe and USA, from Cancer Incidence in Five Continents Vol. IV-VIII. Jpn J Clin Oncol, 37:402-403, 2007

198. Qiu D, Marugame T. Comparison of time trends in uterine cancer incidence (1973-1997) in East Asia, Europe and USA, from Cancer Incidence in Five Continents, Vol. IV VIII. Jpn J Clin Oncol, 37:722-724, 2007

199. Saika K, Matsuda T. Comparison of time trends in lung cancer incidence (1973-97) in East Asia, Europe and USA, from Cancer Incidence in Five Continents Vol. IV VIII. Jpn J Clin Oncol, 37:474-476, 2007

200. Matsuda T, Marugame T. International comparisons of cumulative risk of gallbladder cancer and other biliary tract cancer, from Cancer Incidence in Five Continents Vol. VIII. Jpn J Clin Oncol, 37:74-75, 2007

201. Marugame T, Yamamoto S, Yoshimi I, Sobue T, Inoue M, Tsugane S, Japan Public Health Center-based Prospective Study Group. Patterns of alcohol drinking and all-cause mortality: results from a large-scale population-based cohort study in Japan. Am J Epidemiol, 165:1039-1046, 2007

202. Hirabayashi Y, Miyashita M, Kawa M, Kazuma K, Yamashita K, Okamoto N. Factors relating to terminally ill cancer patients' willingness to continue living at home during the early phase of home care after discharge from clinical cancer centers in Japan. Palliative and Supportive care, 5:19-30, 2007

203. Hamashima C, Saito H, Sobue T. Awareness of and adherence to cancer screening guidelines among health professionals in Japan. Cancer Sci, 98:1241-1247, 2007

204. Tsujinaka T, Sasako M, Yamamoto S, Sano T, Kurokawa Y, Nashimoto A, Kurita A, Katai H, Shimizu T, Furukawa H, Inoue S, Hiratsuka M, Kinoshita T, Arai K, Yamamura Y, for the Gastric Cancer Surgery Study Group of Japan Clinical Oncology Group. Influence of overweight on surgical complications for gastric cancer: results from a randomized control trial comparing D2 and extended para-aortic D3 lymphadenectomy (JCOG9501). Ann of Surg Oncol, 14:355-361, 2007

205. Wakai K, Marugame T, Kuriyama S, Sobue T, Tamakoshi A, Satoh H, Tajima K, Suzuki T, Tsugane S. Decrease in risk of lung cancer death in Japanese men after smoking cessation by age at quitting: pooled analysis of three large-scale cohort studies. Cancer Sci, 98:584-589, 2007

22. Pharmacology Division

206. Cui R, Takahashi F, Ohashi R, Gu T, Yoshioka M, Nishio K, Ohe Y, Tominaga S, Takagi Y, Sasaki S, Fukuchi Y, Takahashi K. Abrogation of the interaction between osteopontin and avb3 integrin reduces tumor growth of human lung cancer cells in mice. Lung Cancer, 57:302-310, 2007

207. Oda Y, Ohishi Y, Basaki Y, Kobayashi H, Hirakawa T, Wake N, Ono M, Nishio K, Kuwano M, Tsuneyoshi M. Prognostic implications of the nuclear localization of Y-box-binding protein-1 and CXCR4 expression in ovarian cancer: their correlation with activated Akt, LRP/MVP and P-glycoprotein expression. Cancer Sci, 98:1020-1026, 2007

23. Tumor Supression and Functional Genomics Project

208. Wakayama T, Sai Y, Ito A, Kato Y, Kurobo M, Murakami Y, Nakashima E, Tsuji A, Kitamura Y, Iseki S. Heterophilic binding of the adhesion molecules poliovirus receptor and immunoglobulin superfamily 4A in the interaction between mouse spermatogenic and Sertoli cells. Biology Reprod, 76:1081-1090, 2007

209. Kawasaki A, Tsuchiya N, Ohashi J, Murakami Y, Fukazawa T, Kusaoi M, Morimoto S, Matsuda K, Hashimoto H, Takasaki Y, Tokunaga K. Role of APRIL (TNSF13) polymorphisms in the susceptibility to systemic lupus erythematosus in Japanese. Rheumatology, 46:776-782, 2007

210. Ito A, Hagiyama M, Oonuma J, Murakami Y, Yokozaki H, Takaki M. Involvement of the SgIGSF/Necl-2 adhesion molecule in degradation of mesenteric mast cells. J Neuro Immunol, 184:209-213, 2007

24. Central Animal Lab

211. Lee H-J, Lee HS, Hur K, Kim WH, Yanagihara K, Becker K-F, Lee KU, Yang H-K. Tumor specificity and in vivo targeting of an antibody against exon 9 deleted E-cadherin in gastric cancer. J Cancer Res Clin Oncol, 133:987-994, 2007

212. Miskad UA, Semba S, Kato H, Matsukawa Y, Kodama Y, Mizuuchi E, Maeda N, Yanagihara K, Yokozaki H. High PRL-3 expression in human gastric cancer is a marker of metastasis and grades of malignancies: an in situ hybridization study. Virchows Arch, 450:303-310, 2007

213. Takeda M, Arao T, Yokote H, Komatsu T, Yanagihara K, Sasaki H, Yamada Y, Tamura T, Fukuoka K, Kimura H, Saijo N, Nishio K. AZD2171 shows potent antitumor activity against gastric cancer over-expressing fibroblast growth factor receptor 2/keratinocyte growth factor receptor. Clin Cancer Res, 13:3051-3057, 2007

214. Tani Y, Akiyama Y, Fukamachi H, Yanagihara K, Yuasa Y. Transcription factor SOX2 up-regulates stomach-specific pepsinogen A gene expression. J Cancer Res Clin Oncol, 133:263-269, 2007

25. President Emeritus

215. Esumi H, Sugimura T. Phenotypic reversion in analbuminemic rats due to an altered splicing mechanism. Proc Jpn Acad Ser B, 83:101-109, 2007