1. Pathology Division

1. Kanai Y. Alterations of DNA methylation and clinicopathological diversity of human cancers. Pathol Int, 58:544-558, 2008

2. Kanai Y. Overexpression of HDACs: a prognostic marker for gastric cancer identified by tissue microarray. Lancet Oncol, 9:91-93, 2008

3. Arai E, Ushijima S, Tsuda H, Fujimoto H, Hosoda F, Shibata T, Kondo T, Imoto I, Inazawa J, Hirohashi S, Kanai Y. Genetic clustering of clear cell renal cell carcinoma based on array-comparative genomic hybridization: its association with DNA methylation alteration and patient outcome. Clin Cancer Res, 14:5531-5539, 2008

4. Heimberger AB, Abou-Ghazal M, Reina-Ortiz C, Yang DS, Sun W, Qiao W, Hiraoka N, Fuller GN. Incidence and prognostic impact of FoxP3⁺ regulatory T cells in human gliomas. Clin Cancer Res, 14:5166-5172, 2008

5. Abou-Ghazal M, Yang DS, Qiao W, Reina-Ortiz C, Wei J, Kong LY, Fuller GN, Hiraoka N, Priebe W, Sawaya R, Heimberger AB. The incidence, correlation with tumor-infiltrating inflammation, and prognosis of phosphorylated STAT3 expression in human gliomas. Clin Cancer Res, 14:8228-8235, 2008

6. Nara S, Shimada K, Kosuge T, Kanai Y, Hiraoka N. Minimally invasive intraductal papillary-mucinous carcinoma of the pancreas: clinicopathologic study of 104 intraductal papillary-mucinous neoplasms. Am J Surg Pathol, 32:243-255, 2008

7. Ochiai H, Nakanishi Y, Fukasawa Y, Sato Y, Yoshimura K, Moriya Y, Kanai Y, Watanabe M, Hasegawa H, Kitagawa Y, Kitajima M, Hirohashi S. A new formula for predicting liver metastasis in patients with colorectal cancer: immunohistochemical analysis of a large series of 439 surgically resected cases. Oncology, 75:32-41, 2008

8. Oka T, Sayano T, Tamai S, Yokota S, Kato H, Fujii G, Mihara K. Identification of a novel protein MICS1 that is involved in maintenance of mitochondrial morphology and apoptotic release of cytochrome c. Mol Biol Cell, 19:2597-2608, 2008

9. Suzuki H, Nakanishi Y, Taniguchi H, Shimoda T, Yamaguchi H, Igaki H, Tachimori Y, Kato H. Two cases of early-stage esophageal malignant melanoma with long-term survival. Pathol Int, 58:432-435, 2008

10. Nara S, Hiraoka N. A case of neurilemoma at the celiac tripod. Jpn J Clin Oncol, 38:649, 2008

11. Batistatou A, Charalabopoulos K, Nakanishi Y, Vagianos C, Hirohashi S, Agnantis NJ, Scopa CD. Differential expression of dysadherin in papillary thyroid carcinoma and microcarcinoma: correlation with E-cadherin. Endocr Pathol, 19:197-202, 2008

12. Sano T, Shimada K, Sakamoto Y, Ojima H, Esaki M, Kosuge T. Prognosis of perihilar cholangiocarcinoma: hilar bile duct cancer versus intrahepatic cholangiocarcinoma involving the hepatic hilus. Ann Surg Oncol, 15:590-599, 2008

13. Nara S, Sano T, Ojima H, Onaya H, Ikeda M, Morizane C, Esaki M, Sakamoto Y, Shimada K, Kosuge T. Liver cryptococcosis manifesting as obstructive jaundice in a young immunocompetent man: report of a case. Surg Today, 38:271-274, 2008

14. Ando M, Nakanishi Y, Asai M, Maeshima A, Matsuno Y. Mucoepidermoid carcinoma of the thyroid gland showing marked ciliation suggestive of its pathogenesis. Pathol Int, 58:741-744, 2008

2. Biochemistry Division

15. Wang R, Dashwood MW, Lohr CV, Fischer KA, Nakagama H, Williams DE, Dashwood RH. b-catenin is strongly elevated in rat colonic epithelium following short-term intermittent treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and a high-fat diet. Cancer Sci, 99:1754-1759, 2008

16. Wang R, Dashwood MW, Lohr CV, Fischer KA, Pereira CB, Louderback M, Nakagama H, Bailey GS, Williams DE, Dashwood RH. Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and b-catenin expression in the rat. Carcinogenesis, 29:834-839, 2008

17. Fukuda T, Kondo Y, Nakagama H. The anti-proliferative effects of the CHFR depend on the forkhead associated domain, but not E3 ligase activity mediated by ring finger domain. PLoS ONE, 3:e1776, 2008

18. Fukuta K, Kohri K, Fukuda H, Watanabe M, Sugimura T, Nakagama H. Induction of multinucleated cells and apoptosis in the PC-3 prostate cancer cell line by low concentrations of polyethylene glycol 1000. Cancer Sci, 99:1055-1062, 2008

19. Fujisawa T, Sugiyama M, Tomimoto A, Wada K, Endo H, Takahashi H, Yoneda K, Yoneda M, Inamori M, Saito S, Terauchi Y, Kadowaki T, Tsuchiya N, Nakagama H, Nakajima A. Inhibition of peroxisome proliferator-activated receptor gamma promotes tumorigenesis through activation of the b-catenin/T cell factor (TCF) pathway in the mouse intestine. J Pharmacol Sci, 108:535-544, 2008

20. Nagao M, Ishikawa S, Nakagama H, Watanabe M. Extrapolation of the animal carcinogenesis threshold to humans. Genes Environ, 30:160-165, 2008

21. Nagata T, Takada Y, Ono A, Nagata K, Konishi Y, Nukina T, Ono M, Matsugami A, Furukawa A, Fujimoto N, Fukuda H, Nakagama H, Katahira M. Elucidation of the mode of interaction in the UP1-telomerase RNA-telomeric DNA ternary complex which serves to recruit telomerase to telomeric DNA and to enhance the telomerase activity. Nucleic Acids Res, 36:6816-6824, 2008

3. Chemotherapy Division

22. Shitashige M, Hirohashi S, Yamada T. Wnt signaling inside the nucleus. Cancer Sci, 99:631-637, 2008

23. Shitashige M, Satow R, Honda K, Ono M, Hirohashi S, Yamada T. Regulation of Wnt signaling by the nuclear pore complex. Gastroenterology, 134:1961-1971, 2008

24. Yamaguchi U, Nakayama R, Honda K, Ichikawa H, Hasegawa T, Shitashige M, Ono M, Shoji A, Sakuma T, Kuwabara H, Shimada Y, Sasako M, Shimoda T, Kawai A, Hirohashi S, Yamada T. Distinct gene expression-defined classes of gastrointestinal stromal tumor. J Clin Oncol, 26:4100-4108, 2008

25. Hara T, Honda K, Shitashige M, Ono M, Matsuyama H, Naito K, Hirohashi S, Yamada T. Role of alpha-actinin-4 in the regulation of endocytosis. Bull Yamaguchi Med School, 55:21-26, 2008

26. Kikuchi S, Honda K, Tsuda H, Hiraoka N, Imoto I, Kosuge T, Umaki T, Onozato K, Shitashige M, Yamaguchi U, Ono M, Tsuchida A, Aoki T, Inazawa J, Hirohashi S, Yamada T. Expression and gene amplification of actinin-4 in invasive ductal carcinoma of the pancreas. Clin Cancer Res, 14:5348-5356, 2008

4. Biology Division

27. Ogiwara H, Kohno T, Nakanishi H, Nagayama K, Sato M, Yokota J. Unbalanced translocation, a major chromosome alteration causing loss of heterozygosity in human lung cancer. Oncogene, 27:4788-4797, 2008

28. Iwakawa R, Kohno T, Anami Y, Noguchi M, Suzuki K, Matsuno Y, Mishima K, Nishikawa R, Tashiro F, Yokota J. Association of p16 homozygous deletions with clinicopathologic characteristics and EGFR/KRAS/p53 mutations in lung adenocarcinoma. Clin Cancer Res, 14:3746-3753, 2008

29. Ohmori K, Endo Y, Yoshida Y, Ohata H, Taya Y, Enari M. Monomeric but not trimeric clathrin heavy chain regulates p53-mediated transcription. Oncogene, 27:2215-2227, 2008

30. Endo Y, Sugiyama A, Li S-A, Ohmori K, Ohata H, Yoshida Y, Shibuya M, Takei K, Enari M, Taya Y. Regulation of clathrin-mediated endocytosis by p53. Genes Cells, 13:375-386, 2008

31. Kumamoto K, Spillare EA, Fujita K, Horikawa I, Yamashita T, Appella E, Nagashima M, Takenoshita S, Yokota J, Harris CC. Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence. Cancer Res, 68:3193-3203, 2008

32. Ajima R, Akazawa H, Kodama M, Takeshita F, Otsuka A, Kohno T, Komuro I, Ochiya T, Yokota J. Deficiency of Myo18B in mice results in embryonic lethality with cardiac myofibrillar aberrations. Genes Cells, 13:987-999, 2008

33. Inoue T, Kon T, Ohkura R, Yamakawa H, Ohara O, Yokota J, Sutoh K. BREK/LMTK2 is a myosin VI-binding protein involved in endosomal membrane trafficking. Genes Cells, 13:483-495, 2008

34. Kohno T, Kunitoh H, Suzuki K, Yamamoto S, Kuchiba A, Matsuno Y, Yanagitani N, Yokota J. Association of KRAS polymorphisms with risk for lung adenocarcinoma accompanied by atypical adenomatous hyperplasias. Carcinogenesis, 29:957-963, 2008

35. Lee K-M, Kang D, Clapper ML, Ingelman-Sundberg M, Ono-Kihara M, Kiyohara C, Min S, Lan Q, Marchand LL, Lin P, Lung ML, Pinarbasi H, Pisani P, Srivatanakul P, Seow A, Sugimura H, Tokudome S, Yokota J, Taioli E. CYP1A1, GSTM1, and GSTT1 polymorphisms, smoking, and lung cancer risk in a pooled analysis among Asian populations. Cancer Epidemiol Biomarkers Prev, 17:1120-1126, 2008

36. Medina PP, Romero OA, Kohno T, Montuenga LM, Pio R, Yokota J, Sanchez-Cespedes M. Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell lines. Hum Mutat, 29:617-622, 2008

37. Hidaka T, Nakahata S, Hatakeyama K, Hamasaki M, Yamashita K, Kohno T, Arai Y, Taki T, Nishida K, Okayama A, Asada Y, Yamaguchi R, Tsubouchi H, Yokota J, Taniwaki M, Higashi Y, Morishita K. Down-regulation of TCF8 is involved in the leukemogenesis of adult T-cell leukemia/lymphoma. Blood, 112:383-393, 2008

5. Cancer Medicine and Biophysics Division

38. Kamino H, Futamura M, Nakamura Y, Kitamura N, Kabu K, Arakawa H. B-cell linker protein prevents aneuploidy by inhibiting cytokinesis. Cancer Sci, 99:2444-2454, 2008

6. Growth Factor Division

39. Uekita T, Tanaka M, Takigahira M, Miyazawa Y, Nakanishi Y, Kanai Y, Yanagihara K, Sakai R. CUB-domain-containing protein 1 regulates peritoneal dissemination of gastric scirrhous carcinoma. Am J Pathol, 172:1729-1739, 2008

40. Jia L, Uekita T, Sakai R. Hyperphosphorylated cortactin in cancer cells plays an inhibitory role in cell motility. Mol Cancer Res, 6:654-662, 2008

41. Tazaki T, Miyazaki K, Hiyama E, Nakamoto T, Sakai R, Yamasaki N, Honda Z, Noda M, Miyasaka N, Sueda T, Honda H. Functional analysis of Src homology 3-encoding exon (exon 2) of p130Cas in primary fibroblasts derived from exon 2-specific knockout mice. Genes Cells, 13:145-157, 2008

42. Nakamoto T, Seo S, Sakai R, Kato T, Kutsuna H, Kurokawa M, Noda M, Miyasaka N, Kitagawa S. Expression and tyrosine phosphorylation of Crk-associated substrate lymphocyte type (Cas-L) protein in human neutrophils. J Cell Biochem, 105:121-128, 2008

7. Molecular Oncology Division

43. Yoshida H, Kitabayashi I. Chromatin regulation by AML1 complex. Int J Hematol, 87:19-24, 2008

44. Tachibana M, Tezuka C, Muroi S, Nishimoto S, Katsumoto T, Nakajima A, Kitabayashi I, Taniuchi I. Phosphorylation of Runx1 at Ser249, Ser266, and Ser276 is dispensable for bone marrow hematopoiesis and thymocyte differentiation. Biochem Biophys Res Commun, 368:536-542, 2008

45. Marshall LJ, Moore AC, Ohki M, Kitabayashi I, Patterson D, Ornelles DA. RUNX1 permits E4orf6-directed nuclear localization of the adenovirus E1B-55K protein and associates with centers of viral DNA and RNA synthesis. J Virol, 82:6395-6408, 2008

46. Tagata Y, Yoshida H, Nguyen LA, Kato H, Ichikawa H, Tashiro F, Kitabayashi I. Phosphorylation of PML is essential for activation of C/EBPe and PU.1 to accelerate granulocytic differentiation. Leukemia, 22:273-280, 2008

47. Hayakawa F, Abe A, Kitabayashi I, Pandolfi PP, Naoe T. Acetylation of PML is involved in histone deacetylase inhibitor-mediated apoptosis. J Biol Chem, 283:24420-24425, 2008

48. Shima Y, Shima T, Chiba T, Irimura T, Pandolfi PP, Kitabayashi I. PML activates transcription by protecting HIPK2 and p300 from SCF^Fbx3-mediated degradation. Mol Cell Biol, 28:7126-7138, 2008

49. Katsumoto T, Yoshida N, Kitabayashi I. Roles of the histone acetyltransferase monocytic leukemia zinc finger protein in normal and malignant hematopoiesis. Cancer Sci, 99:1523-1527, 2008

8. Virology Division

50. Narisawa-Saito M, Yoshimatsu Y, Ohno S, Yugawa T, Egawa N, Fujita M, Hirohashi S, Kiyono T. An in vitro multistep carcinogenesis model for human cervical cancer. Cancer Res, 68:5699-5705, 2008

51. Sugimoto M, Inoko A, Shiromizu T, Nakayama M, Zou P, Yonemura S, Hayashi Y, Izawa I, Sasoh M, Uji Y, Kaibuchi K, Kiyono T, Inagaki M. The keratin-binding protein Albatross regulates polarization of epithelial cells. J Cell Biol, 183:19-28, 2008

52. Hashimoto N, Kiyono T, Wada MR, Umeda R, Goto Y, Nonaka I, Shimizu S, Yasumoto S, Inagawa-Ogashiwa M. Osteogenic properties of human myogenic progenitor cells. Mech Dev, 125:257-269, 2008

53. Shiga M, Saito M, Hattori M, Torii C, Kosaki K, Kiyono T, Suda N. Characteristic phenotype of immortalized periodontal cells isolated from a Marfan syndrome type I patient. Cell Tissue Res, 331:461-472, 2008

54. Tsuruga Y, Kiyono T, Matsushita M, Takahashi T, Kasai N, Matsumoto S, Todo S. Effect of intrasplenic transplantation of immortalized human hepatocytes in the treatment of acetaminophen-induced acute liver failure SCID mice. Transplant Proc, 40:617-619, 2008

55. Hida N, Nishiyama N, Miyoshi S, Kira S, Segawa K, Uyama T, Mori T, Miyado K, Ikegami Y, Cui C, Kiyono T, Kyo S, Shimizu T, Okano T, Sakamoto M, Ogawa S, Umezawa A. Novel cardiac precursor-like cells from human menstrual blood-derived mesenchymal cells. Stem Cells, 26:1695-1704, 2008

56. Sugimoto N, Kitabayashi I, Osano S, Tatsumi Y, Yugawa T, Narisawa-Saito M, Matsukage A, Kiyono T, Fujita M. Identification of novel human Cdt1-binding proteins by a proteomics approach: proteolytic regulation by APC/C^Cdh1. Mol Biol Cell, 19:1007-1021, 2008

57. Mizushina Y, Takeuchi T, Takakusagi Y, Yonezawa Y, Mizuno T, Yanagi K, Imamoto N, Sugawara F, Sakaguchi K, Yoshida H, Fujita M. Coenzyme Q₁₀ as a potent compound that inhibits Cdt1-geminin interaction. Biochim Biophys Acta, 1780:203-213, 2008

58. Mizushina Y, Takeuchi T, Hada T, Maeda N, Sugawara F, Yoshida H, Fujita M. The inhibitory action of SQDG (sulfoquinovosyl diacylglycerol) from spinach on Cdt1-geminin interaction. Biochimie, 90:947-956, 2008

59. Mizushina Y, Takeuchi T, Takakusagi Y, Sugawara F, Sakaguchi K, Yoshida H, Fujita M. Inhibitory action of polyunsaturated fatty acids on Cdt1-geminin interaction. Int J Mol Med, 21:281-290, 2008

60. Tatsumi Y, Ezura K, Yoshida K, Yugawa T, Narisawa-Saito M, Kiyono T, Ohta S, Obuse C, Fujita M. Involvement of human ORC and TRF2 in pre-replication complex assembly at telomeres. Genes to Cells, 13:1045-1059, 2008

61. Ikegami Y, Goto H, Kiyono T, Enomoto M, Kasahara K, Tomono Y, Tozawa K, Morita A, Kohri K, Inagaki M. Chk1 phosphorylation at Ser286 and Ser301 occurs with both stalled DNA replication and damage checkpoint stimulation. Biochim Biophys Res Commun, 377:1227-1231, 2008

62. Scian MJ, Carchman EH, Mohanraj L, Stagliano KE, Anderson MA, Deb D, Crane BM, Kiyono T, Windle B, Deb SP, Deb S. Wild-type p53 and p73 negatively regulate expression of proliferation related genes. Oncogene, 17:2583-2593, 2008

9. Genetics Division

63. Yamada A, Sasaki H, Aoyagi K, Sano M, Fujii S, Daiko H, Nishimura M, Yoshida T, Chiba T, Ochiai A. Expression of cytokeratin 7 predicts survival in stages I/IIA/IIB squamous cell carcinoma of the esophagus. Oncol Rep, 20:1021-1027, 2008

64. Ohta T, Iijima K, Miyamoto M, Nakahara I, Tanaka H, Ohtsuji M, Suzuki T, Kobayashi A, Yokota J, Sakiyama T, Shibata T, Yamamoto M, Hirohashi S. Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth. Cancer Res, 68:1303-1309, 2008

65. Sai K, Saito Y, Sakamoto H, Shirao K, Kurose K, Saeki M, Ozawa S, Kaniwa N, Hirohashi S, Saijo N, Sawada J, Yoshida T. Importance of UDP-glucuronosyltransferase 1A1*6 for irinotecan toxicities in Japanese cancer patients. Cancer Lett, 261:165-171, 2008

66. Sai K, Saito Y, Fukushima-Uesaka H, Kurose K, Kaniwa N, Kamatani N, Shirato K, Yamamoto N, Hamaguchi T, Kunitoh H, Ohe Y, Tamura T, Yamada Y, Minami H, Ohtsu A, Yoshida T, Saijo N, Sawada J. Impact of CYP3A4 haplotypes on irinotecan pharmacokinetics in Japanese cancer patients. Cancer Chemother Pharmacol, 62:529-537, 2008

67. Sakamoto H, Yoshimura K, Saeki N, Katai H, Shimoda T, Matsuno Y, Saito D, Sugimura H, Tanioka F, Kato S, Matsukura N, Matsuda N, Nakamura T, Hyodo I, Nishina T, Yasui W, Hirose H, Hayashi M, Toshiro E, Ohnami S, Sekine A, Sato Y, Totsuka H, Ando M, Takemura R, Takahashi Y, Ohdaira M, Aoki K, Honmyo I, Chiku S, Aoyagi K, Sasaki H, Ohnami S, Yanagihara K, Yoon K-A, Kook M-C, Lee Y-S, Park SR, Kim CG, Choi IJ, Yoshida T, Nakamura Y, Hirohashi S, The Study Group of Millennium Genome Project for Cancer. Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer. Nat Genet, 40:730-740, 2008

68. Yasuda K, Miyake K, Horikawa Y, Hara K, Osawa H, Furuta H, Hirota Y, Mori H, Jonsson A, Sato Y, Yamagata K, Hinokio Y, Wang HY, Tanahashi T, Nakamura N, Oka Y, Iwasaki N, Iwamoto Y, Yamada Y, Seino Y, Maegawa H, Kashiwagi A, Takeda J, Maeda E, Shin HD, Cho YM, Park KS, Lee HK, Ng MC, Ma RC, So WY, Chan JC, Lyssenko V, Tuomi T, Nilsson P, Groop L, Kamatani N, Sekine A, Nakamura Y, Yamamoto K, Yoshida T, Tokunaga K, Itakura M, Makino H, Nanjo K, Kadowaki T, Kasuga M. Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat Gen, 40:1092-1097, 2008

69. Yamashita M, Okamura H, Murakami Y, Sugano K, Yoshida T, Uchitomi Y. Psychological impact and associated factors after disclosure of genetic test results concerning hereditary non-polyposis colorectal cancer. Stress and Health, 24:407-412, 2008

70. Katoh M. Cancer genomics and genetics of FGFR2. Int J Oncol, 33:233-237, 2008

71. Katoh Y, Katoh M. Hedgehog signaling, epithelial-to-mesenchymal transition and miRNA. Int J Mol Med, 22:271-275, 2008

72. Katoh M. WNT signaling in stem cell biology and regenerative medicine. Curr Drug Targets, 9:565-570, 2008

73. Katoh M. RNA technology targeted to the WNT signaling pathway. Cancer Biol Ther, 7:275-277, 2008

74. Katoh Y, Katoh M. Integrative genomic analyses on GLI2: mechanism of Hedgehog priming through basal GLI2 expression, and interaction map of stem cell signaling network with P53. Int J Oncol, 33:881-886, 2008

75. Fukai J, Nishio K, Itakura T, Koizumi F. Antitumor activity of cetuximab against malignant glioma cells overexpressing EGFR deletion mutant variant III. Cancer Sci, 99:2062-2069, 2008

76. Hirakawa A, Sato Y, Hamada C, Yoshimura I. A new test statistic based on shrunken sample variance for identifying differentially expressed genes in small microarray experiments. Bioinformatics and Biology Insights, 2:145-156, 2008

77. Sumitomo M, Koizumi F, Asano T, Horiguchi A, Ito K, Asano T, Kakizoe T, Hayakawa M, Matsumura Y. Novel SN-38-incorporated polymeric micelle, NK012, strongly suppresses renal cancer progression. Cancer Res, 68:1631-1635, 2008

78. Nakajima-Eguchi T, Yasunaga M, Kano Y, Koizumi F, Kato K, Hamaguchi T, Yamada Y, Shirao K, Shimada Y, Matsumura Y. Synergistic antitumor activity of the novel SN-38-incorporating polymeric micelles, NK012, combined with 5-fluorouracil in a mouse model of colorectal cancer, as compared with that of irinotecan plus 5-fluorouracil. Int J Cancer, 122:2148-2153, 2008

79. Sentani K, Oue N, Sakamoto N, Aoyagi K, Sasaki H, and Yasui W. Gene expression profiling using microarray and SAGE identifies PLUNC as a marker for hepatoid adenocarcinoma of the stomach. Mod Pathol, 21:464-475, 2008

80. Chiba H, Ishii G, Ito TK, Aoyagi K, Sasaki H, Nagai K, and Ochiai A. CD105 positive cells in pulmonary arterial blood of adult human lung cancer patients include mesenchymal progenitors. Stem Cells, 26:2523-2530, 2008

81. Katanasaka Y, Ida T, Asai T, Shimizu K, Koizumi F, Maeda N, Baba K, Oku N. Antiangiogenic cancer therapy using tumor vasculature-targeted liposomes encapsulating 3-(3,5-dimethyl-1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one, SU5416. Cancer Lett, 270:260-268, 2008

82. Yamada Y, Arao T, Gotoda T, Taniguchi H, Oda I, Shirao K, Shimada Y, Hamaguchi T, Kato K, Hamano T, Koizumi F, Tamura T, Saito D, Shimoda T, Saka M, Fukagawa T, Katai H, Sano T, Sasako M, Nishio K. Identification of prognostic biomarkers in gastric cancer using endoscopic biopsy samples. Cancer Sci, 99:2193-2199, 2008

83. Dohi Y, Ikura T, Hoshikawa Y, Katoh Y, Ota K, Nakanome A, Muto A, Omura S, Ohta T, Ito A, Yoshida M, Noda T, Igarashi K. Bach1 inhibits oxidative stress-induced cellular senescence by impeding p53 function on chromatin. Nat Str Mol Biol, 15:1246-1254, 2008

84. Kohu K, Kubo M, Ichikawa H, Ohno S, Habu S, Sato T, Satake M. Pleiotropic roles of Runx transcription factors in the differentiation and function of T lymphocytes. Curr Immunol Rev, 4:101-105, 2008

85. Li X, Jia Z, Shen Y, Ichikawa H, Jarvik J, Nagele RG, Goldberg GS. Coordinate suppression of Sdpr and Fhl1 expression in tumors of the breast, kidney, and prostate. Cancer Sci, 99:1326-1333, 2008

86. Shimizu N, Noda S, Katayama K, Ichikawa H, Kodama H, Miyoshi H. Identification of genes potentially involved in supporting hematopoietic stem cell activity of stromal cell line MC3T3-G2/PA6. Int J Hematol, 87:239-245, 2008

87. Noda S, Horiguchi K, Ichikawa H, Miyoshi H. Repopulating activity of ex vivo-expanded murine hematopoietic stem cells resides in the CD48^-c-Kit⁺Sca-1⁺lineage marker^- cell population. Stem Cells, 26:646-655, 2008

88. Hanada S, Maeshima A, Matsuno Y, Ohta T, Ohki M, Yoshida T, Hayashi Y, Yoshizawa Y, Hirohashi S, Sakamoto M. Expression profile of early lung adenocarcinoma: identification of MRP3 as a molecular marker for early progression. J Pathol, 216:75-82, 2008

10. Carcinogenesis Division

89. Nakajima T, Enomoto S, Ushijima T. DNA methylation: a marker for carcinogen exposure and cancer risk. Environ Health Prev Med, 13:8-15, 2008

90. Abe M, Watanabe N, McDonell N, Takato T, Ohira M, Nakagawara A, Ushijima T. Identification of genes targeted by CpG island methylator phenotype in neuroblastomas, and their possible integrative involvement in poor prognosis. Oncology, 74:50-60, 2008

91. Yamashita S, Takahashi S, McDonell N, Watanabe N, Niwa T, Hosoya K, Tsujino Y, Shirai T, Ushijima T. Methylation silencing of transforming growth factor-b receptor type II in rat prostate cancers. Cancer Res, 68:2112-2121, 2008

92. Jones PA, Archer TK, Baylin SB, Beck S, Berger S, Bernstein BE, Carpten JD, Clark SJ, Costello JF, Doerge RW, Esteller M, Feinberg AP, Gingeras TR, Greally JM, Henikoff S, Herman JG, Jackson-Grusby L, Jenuwein T, Jirtle RL, Kim YJ, Laird PW, Lim B, Martienssen R, Polyak K, Stunnenberg H, Tlsty TD, Tycko B, Ushijima T, Zhu J, Pirrotta V, Allis CD, Elgin SC, Jones PA, Martienssen R, Rine J, Wu C, American Association for Cancer Research Human Epigenome Task Force; European Union, Network of Excellence, Scientific Advisory Board. Moving AHEAD with an international human epigenome project. Nature, 454:711-715, 2008

93. Imaoka T, Yamashita S, Nishimura M, Kakinuma S, Ushijima T, Shimada Y. Gene expression profiling distinguishes between spontaneous and radiation-induced rat mammary carcinomas. J Radiat Res, 49:349-360, 2008

94. Zhao Y, Miyashita K, Ando T, Kakeji Y, Yamanaka T, Taguchi K, Ushijima T, Oda S, Maehara Y. Exclusive KRAS mutation in microsatellite-unstable human colorectal carcinomas with sequence alterations in the DNA mismatch repair gene, MLH1. Gene, 423:188-193, 2008

11. Section for Studies on Metastasis

95. Hokaiwado N, Takeshita F, Banas A, Ochiya T. RNAi-based drug discovery and its application to therapeutics. IDrugs, 11:274-278, 2008

96. Honma K, Iwao-Koizumi K, Takeshita F, Yamamoto Y, Yoshida T, Nishio K, Nagahara S, Kato K, Ochiya T. RPN2 gene confers docetaxel resistance in breast cancer. Nat Med, 14:939-948, 2008

97. Takahashi R, Kanesashi S, Inoue T, Enomoto T, Kawano M, Tsukamoto H, Takeshita F, Imai T, Ochiya T, Kataoka K, Yamaguchi Y, Handa H. Presentation of functional foreign peptides on the surface of SV40 virus-like particles. J Biotechnol, 135:385-392, 2008

98. Nakajima TE, Yanagihara K, Takigahira M, Yasunaga M, Kato K, Hamaguchi T, Yamada Y, Shimada Y, Mihara K, Ochiya T, Matsumura Y. Antitumor effect of SN-38-releasing polymeric micelles, NK012, on spontaneous peritoneal metastases from orthotopic gastric cancer in mice compared with irinotecan. Cancer Res, 68:9318-9322, 2008

99. Ochiya T, Honma K, Takeshita F, Nagahara S. Optical imaging of RNAi-mediated silencing of cancer. Proc of SPIE, 6868, 2008

100. Yu D, Sekine E, Fujimori A, Ochiya T, Okayasu R. Down regulation of BRCA2 causes radio-sensitization of human tumor cells in vitro and in vivo. Cancer Sci, 99:810-815, 2008

101. Hokaiwado N, Takeshita F, Naiki-Ito A, Asamoto M, Ochiya T, Shirai T. Glutathione S-transferase Pi mediates proliferation of andorogen-independent prostate cancer cells. Carcinogenesis, 29:1134-1138, 2008

102. Matoba T, Orba Y, Suzuki T, Makino Y, Shichinohe H, Kuroda S, Ochiya T, Itoh H, Tanaka S, Nagashima K, Sawa H. An siRNA against JC virus (JCV) agnoprotein inhibits JCV infection in JCV-producing cells inoculated in nude mice. Neuropathology, 28:286-294, 2008

103. Osaki M, Takeshita F, Ochiya T. MicroRNAs as biomarkers and therapeutic drugs in human cancer. Biomarkers, 13:658-670, 2008

104. Kosaka N, Sugiura K, Yamamoto Y, Yoshioka Y, Miyazaki H, Komatsu N, Ochiya T, Kato T. Identification of erythropoietin-induced microRNAs in haematopoietic cells during erythroid differentiation. Br J Haematol, 142:293-300, 2008

105. Yamamoto Y, Banas A, Murata S, Ishikawa M, Lim CR, Teratani T, Hatada I, Matsubara K, Kato T, Ochiya T. A comparative analysis of the transcriptome and signal pathways in hepatic differentiation of human adipose mesenchymal stem cells. FEBS J, 275:1260-1273, 2008

106. Banas A, Teratani T, Yamamoto Y, Tokuhara M, Takeshita F, Osaki M, Kawamata M, Kato T, Okochi H, Ochiya T. IFATS collection: in vivo therapeutic potential of human adipose tissue mesenchymal stem cells after transplantation into mice with liver injury. Stem Cells, 26:2705-2712, 2008

107. Takeuchi T, Ochiya T, Takezawa T. Tissue array substratum composed of histological sections: a new platform for orienting differentiation of embryonic stem cells towards hepatic lineage. Tissue Eng Part A, 14:267-274, 2008

108. Kodama M, Takeshita F, Kanegasaki S, Ochiya T, Quinn G. Pancreatic endocrine and exocrine cell ontogeny from renal capsule-transplanted embryonic stem cells in streptozocin-injured mice. J Histochem Cytochem, 56:33-44, 2008

109. Ueda S, Kawamata M, Teratani T, Shimizu T, Tamai Y, Ogawa H, Hayashi K, Tsuda H, Ochiya T. Establishment of rat embryonic stem cells and making of chimera rats. PLoS ONE, 3, 2008

12. Section for Studies on Host-Immune Response

110. Yoshida K, Kondoh A, Narumi K, Yoshida T, Aoki K. Extracellular matrix interacts with interferon a protein: retention and display of cytotoxicity. Biochem Biophys Res Commun, 376:299-304, 2008

111. Chen S, Ndhlovu LC, Takahashi T, Takeda K, Ikarashi Y, Kikuchi T, Murata K, Pandolfi PP, Riccardi C, Ono M, Sugamura K, Ishii N. Co-inhibitory roles for glucocorticoid-induced TNF receptor in CD1d-dependent natural killer T cells. Eur J Immunol, 38:2229-2240, 2008

112. Imataki O, Heike Y, Makiyama H, Iizuka A, Ishida T, Wakasugi H, Takaue Y. Insufficient ex vivo expansion of Va24⁺ natural killer T cells in malignant lymphoma patients related to the suppressed expression of CD1d molecules on CD14⁺ cells. Cytotherapy, 10:497-506, 2008

13. Cancer Genomics Project

113. Shibata T, Kokubu A, Gotoh M, Ojima H, Ohta T, Yamamoto M, Hirohashi S. Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer. Gastroenterology, 135:1358-1368, 2008

114. Shibata T, Ohta T, Tong KI, Kokubu A, Odogawa R, Tsuta K, Asamura H, Yamamoto M, Hirohashi S. Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy. PNAS, 105:13568-13573, 2008

115. Suzuki A, Shibata T, Shimada Y, Murakami Y, Horii A, Shiratori K, Hirohashi S, Inazawa J, Imoto I. Identification of SMURF1 as a possible target for 7q21.3-22.1 amplification detected in a pancreatic cancer cell line by in-house array-based comparative genomic hybridization. Cancer Sci, 99:986-994, 2008

116. Arima Y, Inoue Y, Shibata T, Hayashi H, Nagano O, Saya H, Taya Y. Rb depletion results in deregulation of E-cadherin and induction of cellular phenotypic changes that are characteristic of the epithelial-to-mesenchymal transition. Cancer Res, 68:5104-5112, 2008

14. Cancer Prevention Basic Research Project

117. Terasaki M, Totsuka Y, Nishimura K, Mukaisho K, Chen K-H, Hattori T, Takamura-Enya T, Sugimura T, Wakabayashi K. Detection of endogenous DNA adducts, O⁶-carboxymethyl-2'-deoxyguanosine and 3-ethanesulfonic acid-2'-deoxycytidine, in the rat stomach after duodenal reflux. Cancer Sci, 99:1741-1746, 2008

118. Watanabe T, Takahashi K, Konishi E, Hoshino Y, Hasei T, Asanoma M, Hirayama T, Wakabayashi K. Mutagenicity of surface soil from residential areas in Kyoto city, Japan, and identification of major mutagens. Mutat Res, 649:201-212, 2008

119. Hirata A, Tsukamoto T, Sakai H, Takasu S, Ban H, Imai T, Totsuka Y, Nishigaki R, Wakabayashi K, Yanai T, Masegi T, Tatematsu M. Carcinogenic risk of heterocyclic amines in combination: assessment with a liver initiation model. Food Chem Toxicol, 46:2003-2009, 2008

120. Oda Y, Watanabe T, Terao Y, Nukaya H, Wakabayashi K. Genotoxic activation of 2-phenylbenzotriazole-type compounds by human cytochrome P4501A1 and N-acetyltransferase expressed in Salmonella typhimurium umu strains. Mutat Res, 654:52-57, 2008

121. Amanuma K, Tone S, Nagaya M, Matsumoto M, Watanabe T, Totsuka Y, Wakabayashi K, Aoki Y. Mutagenicity of 2-[2-(acetylamino)-4-[bis(2-hydroxyethyl)amino]-5-methoxyphenyl]-5-amino-7-bromo-4-chloro-2H-benzotriazole (PBTA-6) and benzo[a]pyrene (BaP) in the gill and hepatopancreas of rpsL transgenic zebrafish. Mutat Res, 656:36-43, 2008

122. Ohe T, Watanabe T, Nonouchi Y, Hasei T, Agou Y, Tani M, Wakabayashi K. Identification of a new mutagen, 4,4'-diamino-3,3'-dichloro-5-nitrobiphenyl, in river water flowing through an industrial area in Wakayama, Japan. Mutat Res, 655:28-35, 2008

123. Deguchi Y, Wu NX, Toyoizumi T, Masuda S, Nagaoka H, Watanabe T, Totsuka Y, Wakabayashi K, Kinae N. Application of a new bioassay technique using goldfish for assessment of water toxicity. Environ Toxicol, 23:720-727, 2008

124. Mutoh M, Niho N, Komiya M, Takahashi M, Ohtsubo R, Nakatogawa K, Ueda K, Sugimura T, Wakabayashi K. Plasminogen activator inhibitor-1 (Pai-1) blockers suppress intestinal polyp formation in Min mice. Carcinogenesis, 29:824-829, 2008

125. Takahashi M, Kitahashi T, Ishigamori R, Mutoh M, Komiya M, Sato H, Kamanaka Y, Naka M, Maruyama T, Sugimura T, Wakabayashi K. Increased expression of inducible nitric oxide synthase (iNOS) in N-nitrosobis(2-oxopropyl)amine-induced hamster pancreatic carcinogenesis and prevention of cancer development by ONO-1714, an iNOS inhibitor. Carcinogenesis, 29:1608-1613, 2008

126. Kitahashi T, Takahashi M, Yamada Y, Oghiso Y, Yokohira M, Imaida K, Tsutsumi M, Takasuka N, Sugimura T, Wakabayashi K. Occurrence of mutations in the epidermal growth factor receptor gene in X-ray-induced rat lung tumors. Cancer Sci, 99:241-245, 2008

127. Hori Y, Takasuka N, Mutoh M, Kitahashi T, Kojima S, Imaida K, Suzuki M, Kohara K, Yamamoto S, Moriyama N, Sugimura T, Wakabayashi K. Periodic analysis of urethane-induced pulmonary tumors in living A/J mice by respiration-gated X-ray microcomputed tomography. Cancer Sci, 99:1774-1777, 2008

128. Ueda N, Maehara Y, Tajima O, Tabata S, Wakabayashi K, Kono S. Genetic polymorphisms of cyclooxygenase-2 and colorectal adenoma risk: The Self Defense Forces Health Study. Cancer Sci, 99:576-581, 2008

129. Ohshima S, Yamamoto S, Yamaji T, Suzuki M, Mutoh M, Iwasaki M, Sasazuki S, Kotera K, Tsugane S, Muramatsu Y, Moriyama N. Development of an automated 3D segmentation program for volume quantification of body fat distribution using CT. Nippon Hoshasen Gijutsu Gakkai Zasshi, 64:1177-1181, 2008

130. Matsumoto Y, Nakano T, Yamamoto M, Matsushima-Hibiya Y, Odagiri K, Yata O, Koyama K, Sugimura T, Wakabayashi K. Distribution of cytotoxic and DNA ADP-ribosylating activity in crude extracts from butterflies among the family Pieridae. Proc Natl Acad Sci USA, 105:2516-2520, 2008

15. Cancer Stem Cell Project

131. Possemato R, Timmons JC, Bauerlein EL, Wada N, Baldwin A, Masutomi K, Hahn WC. Suppression of hPOT1 in diploid human cells results in an hTERT-dependent alteration of telomere length dynamics. Mol Cancer Res, 6:1582-1593, 2008

132. Imamura S, Uchiyama J, Koshimizu E, Hanai J, Raftopoulou C, Murphey RD, Bayliss PE, Imai Y, Burns CE, Masutomi K, Gagos S, Zon LI, Roberts TM, Kishi S. A non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis. PLoS ONE, 3:e3364, 2008

16. Early Oncogenesis Research Project

133. Kim M, Miyamoto S, Sugie S, Yasui Y, Ishigamori-Suzuki R, Murakami A, Nakagama H, Tanaka T. A tobacco-specific carcinogen, NNK, enhances AOM/DSS-induced colon carcinogenesis in male A/J mice. In Vivo, 22:557-563, 2008

134. Yoneda K, Tomimoto A, Endo H, Iida H, Sugiyama M, Takahashi H, Mawatari H, Nozaki Y, Fujita K, Yoneda M, Inamori M, Nakajima N, Wada K, Nagashima Y, Nakagama H, Uozaki H, Fukayama M, Nakajima A. Expression of adiponectin receptors, AdipoR1 and AdipoR2, in normal colon epithelium and colon cancer tissue. Oncol Rep, 20:479-483, 2008

135. Fujisawa T, Endo H, Tomimoto A, Sugiyama M, Takahashi H, Saito S, Inamori M, Nakajima N, Watanabe M, Kubota N, Yamauchi T, Kadowaki T, Wada K, Nakagama H, Nakajima A. Adiponectin suppresses colorectal carcinogenesis under the high-fat diet condition. Gut, 57:1531-1538, 2008

136. Tomimoto A, Endo H, Sugiyama M, Fujisawa T, Hosono K, Takahashi H, Nakajima N, Nagashima Y, Wada K, Nakagama H, Nakajima A. Metformin suppresses intestinal polyp growth in Apc^Min/+ mice. Cancer Sci, 99:2136-2141, 2008

137. Fujisawa T, Nakajima A, Fujisawa N, Takahashi H, Ikeda I, Tomimoto A, Yonemitsu K, Nakajima N, Kudo C, Wada K, Kubota N, Terauchi Y, Kadowaki T, Nakagama H, Blumberg RS. Peroxisome proliferator-activated receptor g (PPARg) suppresses colonic epithelial cell turnover and colon carcinogenesis through inhibition of the b-catenin/T cell factor (TCF) pathway. J Pharmacol Sci, 106:627-638, 2008

138. Nakajima A, Tomimoto A, Fujita K, Sugiyama M, Takahashi H, Ikeda I, Hosono K, Endo H, Yoneda K, Iida H, Inamori M, Kubota K, Saito S, Nakajima N, Wada K, Nagashima Y, Nakagama H. Inhibition of peroxisome proliferator-activated receptor g activity suppresses pancreatic cancer cell motility. Cancer Sci, 99:1892-1900, 2008

139. Abe Y, Oda-Sato E, Tobiume K, Kawaguchi K, Taya Y, Okamoto K, Oren M, Tanaka N. Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2. Proc Natl Acad Sci USA, 105:4838-4843, 2008

17. Proteome Bioinformatics Project

140. Kondo T. Tissue proteomics for cancer biomarker development - Laser microdissection and 2D-DIGE - BMB reports, 41:626-634, 2008

141. Kondo T. Cancer proteomics for biomarker development. J Proteomics Bioinformatics, 1:477-484, 2008

142. Orimo T, Ojima H, Hiraoka N, Saito S, Kosuge T, Kakisaka T, Yokoo H, Nakanishi K, Kamiyama T, Todo S, Hirohashi S, Kondo T. Proteomic profiling reveals the prognostic value of adenomatous polyposis coli-end-binding protein 1 in hepatocellular carcinoma. Hepatology, 48:1851-1863, 2008

143. Saito S, Ojima H, Ichikawa H, Hirohashi S, Kondo T. Molecular background of a-fetoprotein in liver cancer cells as revealed by global RNA expression analysis. Cancer Sci, 99:2402-2409, 2008

144. Kawai A, Kondo T, Suehara Y, Kikuta K, Hirohashi S. Global protein-expression analysis of bone and soft tissue sarcomas. Clin Orthop Relat Res, 466:2099-2106, 2008

145. Suehara Y, Kondo T, Seki K, Shibata T, Fujii K, Gotoh M, Hasegawa T, Shimada Y, Sasako M, Shimoda T, Kurosawa H, Beppu Y, Kawai A, Hirohashi S. Pfetin as a prognostic biomarker of gastrointestinal stromal tumors revealed by proteomics. Clin Cancer Res, 14:1707-1717, 2008

18. Tumor Endocrinology Project

146. Ohkura N, Nagamura Y, Tsukada T. Differential transactivation by orphan nuclear receptor NOR1 and its fusion gene product EWS/NOR1: possible involvement of poly(ADP-ribose) polymerase I, PARP-1. J Cell Biochem, 105:785-800, 2008

147. Liu C, Takahashi M, Li Y, Song S, Dillon TJ, Shinde U, Stork PJ. Ras is required for the cyclic AMP-dependent activation of Rap1 via Epac2. Mol Cell Biol, 28:7109-7125, 2008

19. Epidemiology and Prevention Division

148. Kurahashi N, Inoue M, Liu Y, Iwasaki M, Sasazuki S, Sobue T, Tsugane S, for the JPHC Study Group. Passive smoking and lung cancer in Japanese non-smoking women: a prospective study. Int J Cancer, 122:653-657, 2008

149. Shimazu T, Inoue M, Sasazuki S, Iwasaki M, Kurahashi N, Yamaji T, Tsugane S, Japan Public Health Center-based Prospective Study Group. Alcohol and risk of lung cancer among Japanese men: data from a large-scale population-based cohort study, the JPHC study. Cancer Causes Control, 19:1095-1102, 2008

150. Inoue M, Iso H, Yamamoto S, Kurahashi N, Iwasaki M, Sasazuki S, Tsugane S, for the Japan Public Health Center-Based Prospective Study Group. Daily total physical activity level and premature death in men and women: results from a large-scale population-based cohort study in Japan (JPHC Study). Ann Epidemiol, 18:522-530, 2008

151. Inoue M, Yamamoto S, Kurahashi N, Iwasaki M, Sasazuki S, Tsugane S, for the Japan Public Health Center-Based Prospective Study Group. Daily total physical activity level and total cancer risk in men and women: results from a large-scale population-based cohort study in Japan. Am J Epidemiol, 168:391-403, 2008

152. Takachi R, Inoue M, Ishihara J, Kurahashi N, Iwasaki M, Sasazuki S, Iso H, Tsubono Y, Tsugane S, for the JPHC Study Group. Fruit and vegetable intake and risk of total cancer and cardiovascular disease Japan Public Health Center-Based Prospective Study. Am J Epidemiol, 167:59-70, 2008

153. Yamaji T, Inoue M, Sasazuki S, Iwasaki M, Kurahashi N, Shimazu T, Tsugane S, for the Japan Public Health Center-based Prospective Study Group. Fruit and vegetable consumption and squamous cell carcinoma of the esophagus in Japan: the JPHC study. Int J Cancer, 123:1935-1940, 2008

154. Ishiguro S, Inoue M, Kurahashi N, Iwasaki M, Sasazuki S, Tsugane S. Risk factors of biliary tract cancer in a large-scale population-based cohort study in Japan (JPHC study): with special focus on cholelithiasis, body mass index, and their effect modification. Cancer Causes Control, 19:33-41, 2008

155. Kurahashi N, Inoue M, Iwasaki M, Sasazuki S, Tsugane S, for the Japan Public Health Center-Based Prospective Study Group. Dairy product, saturated fatty acid, and calcium intake and prostate cancer in a prospective cohort of Japanese men. Cancer Epidemiol Biomarkers Prev, 17:930-937, 2008

156. Kurahashi N, Sasazuki S, Iwasaki M, Inoue M, Tsugane S, for the JPHC Study Group. Green tea consumption and prostate cancer risk in Japanese men: a prospective study. Am J Epidemiol, 167:71-77, 2008

157. Shimazu T, Inoue M, Sasazuki S, Iwasaki M, Kurahashi N, Yamaji T, Tsugane S, for the JPHC Study Group. Coffee consumption and risk of endometrial cancer: a prospective study in Japan. Int J Cancer, 123:2406-2410, 2008

158. Akhter M, Inoue M, Kurahashi N, Iwasaki M, Sasazuki S, Tsugane S, for the Japan Public Health Center-Based Prospective Study Group. Dietary soy and isoflavone intake and risk of colorectal cancer in the Japan public health center-based prospective study. Cancer Epidemiol Biomarkers Prev, 17:2128-2135, 2008

159. Ishihara J, Inoue M, Iwasaki M, Sasazuki S, Tsugane S. Dietary calcium, vitamin D, and the risk of colorectal cancer. Am J Clin Nutr, 88:1576-1583, 2008

160. Persson C, Inoue M, Sasazuki S, Kurahashi N, Iwasaki M, Ye W, Tsugane S, for the JPHC Study Group. Female reproductive factors and the risk of gastric cancer in a large-scale population-based cohort study in Japan (JPHC study). Eur J Cancer Prev, 17:345-353, 2008

161. Akhter M, Inoue M, Kurahashi N, Iwasaki M, Sasazuki S, Tsugane S, JPHC Study Group. Reproductive factors, exogenous female hormone use and colorectal cancer risk: the Japan Public Health Center-based Prospective Study. Eur J Cancer Prev, 17:515-524, 2008

162. Iwasaki M, Inoue M, Otani T, Sasazuki S, Kurahashi N, Miura T, Yamamoto S, Tsugane S. Plasma isoflavone level and subsequent risk of breast cancer among Japanese women: a nested case-control study from the Japan Public Health Center-based Prospective Study Group. J Clin Oncol, 26:1677-1683, 2008

163. Kurahashi N, Iwasaki M, Inoue M, Sasazuki S, Tsugane S. Plasma isoflavones and subsequent risk of prostate cancer in a nested case-control study: the Japan Public Health Center. J Clin Oncol, 26:5923-5929, 2008

164. Otani T, Iwasaki M, Sasazuki S, Inoue M, Tsugane S, The Japan Public Health Center-based Prospective Study Group. Plasma folate and risk of colorectal cancer in a nested case-control study: the Japan Public Health Center-based prospective study. Cancer Causes Control, 19:67-74, 2008

165. Sasazuki S, Inoue M, Miura T, Iwasaki M, Tsugane S, for the Japan Health Center-based Prospective Study Group. Plasma tea polyphenols and gastric cancer risk: a case-control study nested in a large population-based prospective study in Japan. Cancer Epidemiol Biomarkers Prev, 17:343-351, 2008

166. Tatemichi M, Sasazuki S, Inoue M, Tsugane S, for the Japan Public Health Center Study Group. Different etiological role of Helicobacter pylori (Hp) infection in carcinogenesis between differentiated and undifferentiated gastric cancers: a nested case-control study using IgG titer against Hp surface antigen. Acta Oncol, 47:360-365, 2008

167. Iwasaki M, Inoue M, Sasazuki S, Kurahashi N, Itoh H, Usuda M, Tsugane S, Japan Public Health Center-based Prospective Study Group. Plasma organochlorine levels and subsequent risk of breast cancer among Japanese women: a nested case-control study. Sci Total Environ, 402:176-183, 2008

168. Persson C, Sasazuki S, Inoue M, Kurahashi N, Iwasaki M, Miura T, Ye W, Tsugane S, for the JPHC Study Group. Plasma levels of carotenoids, retinol and tocopherol and the risk of gastric cancer in Japan: a nested case-control study. Carcinogenesis, 29:1042-1048, 2008

169. Ishihara J, Iso H, Inoue M, Iwasaki M, Okada K, Kita Y, Kokubo Y, Okayama A, Tsugane S, for the JPHC Study Group. Intake of folate, vitamin B-6 and vitamin B-12 and the risk of CHD: the Japan Public Health Center-Based Prospective Study Cohort I. J Am Coll Nutr, 27:127-136, 2008

170. Ito S, Takachi R, Inoue M, Kurahashi N, Iwasaki M, Sasazuki S, Iso H, Tsubono Y, Tsugane S, the JPHC Study Group. Education in relation to incidence of and mortality from cancer and cardiovascular disease in Japan. Eur J Public Health, 18:466-472, 2008

171. Chei CL, Iso H, Yamagishi K, Inoue M, Tsugane S. Body mass index and weight change since 20 years of age and risk of coronary heart disease among Japanese: the Japan Public Health Center-Based Study. Int J Obes (Lond), 32:144-151, 2008

172. Ikeda A, Iso H, Kawachi I, Yamagishi K, Inoue M, Tsugane S, JPHC Study Group. Social support and stroke and coronary heart disease: the JPHC study cohorts II. Stroke, 39:768-775, 2008

173. Umesawa M, Iso H, Ishihara J, Saito I, Kokubo Y, Inoue M, Tsugane S, JPHC Study Group. Dietary calcium intake and risks of stroke, its subtypes, and coronary heart disease in Japanese: the JPHC Study Cohort I. Stroke, 39:2449-2456, 2008

174. Honjo K, Iso H, Inoue M, Tsugane S, Japan Public Health Center-based Prospective Study Group. Education, social roles, and the risk of cardiovascular disease among middle-aged Japanese women: the JPHC Study Cohort I. Stroke, 39:2886-2890, 2008

175. Ikeda A, Iso H, Kawachi I, Inoue M, Tsugane S, for the JPHC Study Group. Type A behaviour and risk of coronary heart disease: the JPHC Study. Int J Epidemiol, 37:1395-1405, 2008

176. Matsushita Y, Takahashi Y, Mizoue T, Inoue M, Noda M, Tsugane S, the JPHC Study Group. Overweight and obesity trends among Japanese adults: a 10-year follow-up of the JPHC Study. Int J Obes, 32:1861-1867, 2008

177. Kato M, Takahashi Y, Inoue M, Tsugane S, Kadowaki T, Noda M, for JPHC study group. Comparisons between anthropometric indices for predicting the metabolic syndrome in Japanese. Asia Pac J Clin Nutr, 17:223-228, 2008

178. Otani T, Iwasaki M, Sasazuki S, Inoue M, Tsugane S, The Japan Public Health Center-based Prospective Study Group. Reply to Brockton's letter. Cancer Causes Control, 19:1003, 2008

179. Shimazu T, Tsuji I, Inoue M, Wakai K, Nagata C, Mizoue T, Tanaka K, Tsugane S, for the Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan. Alcohol drinking and gastric cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population. Jpn J Clin Oncol, 38:8-25, 2008

180. Tanaka K, Tsuji I, Wakai K, Nagata C, Mizoue T, Inoue M, Tsugane S, for the Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan. Alcohol drinking and liver cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population. Jpn J Clin Oncol, 38:816-838, 2008

181. Mizoue T, Inoue M, Wakai K, Nagata C, Shimazu T, Tsuji I, Otani T, Tanaka K, Matsuo K, Tamakoshi A, Sasazuki S, Tsugane S, for the Research Group for Development and Evaluation of Cancer Prevention Strategies in Japan. Alcohol drinking and colorectal cancer in Japanese: a pooled analysis of results from five cohort studies. Am J Epidemiol, 167:1397-1406, 2008

182. Sasazuki S, Hayashi T, Nakachi K, Sasaki S, Tsubono Y, Okubo S, Hayashi M, Tsugane S. Protective effect of vitamin C on oxidative stress: a randomized controlled trial. Int J Vitam Nutr Res, 78:121-128, 2008

183. Iwasaki M, Mameri CP, Hamada GS, Tsugane S. Secular trends in cancer mortality among Japanese immigrants in the state of Sao Paulo, Brazil, 1979-2001. Eur J Cancer Prev, 17:1-8, 2008

184. Itoh H, Iwasaki M, Nakajima Y, Endo Y, Hanaoka T, Sasaki H, Tanaka T, Yang B, Tsugane S. A case-control study of the association between urinary cadmium concentration and endometriosis in infertile Japanese women. Sci Total Environ, 402:171-175, 2008

185. Yamano Y, Miyakawa S, Iizumi K, Itoh H, Iwasaki M, Tsugane S, Kagawa J, Nakadate T. Long-term study of urinary bisphenol A in elementary shool children. Environ Health Prev Med, 13:332-337, 2008

186. Saito-Nakaya K, Nakaya N, Akechi T, Inagaki M, Asai M, Goto K, Nagai K, Nishiwaki Y, Tsugane S, Fukudo S, Uchitomi Y. Marital status and non-small cell lung cancer survival: the Lung Cancer Database Project in Japan. Psychooncology, 17:869-876, 2008

187. Suzuki Y, Endo Y, Ogawa M, Matsuda M, Nakajima Y, Onda N, Iwasaki M, Tsugane S. Determination of sub-ppb cadmium in urine by solid-phase extraction and inductively coupled plasma-mass spectrometry. Anal Sci, 24:1049-1052, 2008

188. Nakaya N, Saito-Nakaya K, Akechi T, Kuriyama S, Inagaki M, Kikuchi N, Nagai K, Tsugane S, Nishiwaki Y, Tsuji I, Uchitomi Y. Negative psychological aspects and survival in lung cancer patients. Psychooncology, 17:466-473, 2008

189. Ikeda S, Sasazuki S, Natsukawa S, Shaura K, Koizumi Y, Kasuga Y, Ohnami S, Sakamoto H, Yoshida T, Iwasaki M, Tsugane S. Screening of 214 single nucleotide polymorphisms in 44 candidate cancer susceptibility genes: a case-control study on gastric and colorectal cancers in the Japanese population. Am J Gastroenterol, 103:1476-1487, 2008

190. Hasebe T, Konishi M, Iwasaki M, Nakagohri T, Takahashi SI, Gotohda N, Kinoshita T, Ochiai A. Primary tumor/-vessel tumor/-nodal tumor classification of extrahepatic bile duct carcinoma. Hum Pathol, 39:37-48, 2008

20. Cancer Information Services and Surveillance Division

191. Sobue T. Current activities and future directions of cancer registration system in Japan. Int J Clin Oncol, 13:97-101, 2008

192. Matsuda T, Marugame T, Kamo K, Katanoda K, Ajiki W, Sobue T. Cancer incidence and incidence rates in Japan in 2002: based on data from 11 population-based cancer registries. Jpn J Clin Oncol, 38:641-648, 2008

193. Shibata A, Matsuda T, Ajiki W, Sobue T. Trend in incidence of adenocarcinoma of the esophagus in Japan, 1993-2001. Jpn J Clin Oncol, 38:464-468, 2008

194. Kamo K, Katanoda K, Matsuda T, Marugame T, Ajiki W, Sobue T. Lifetime and age-conditional probabilities of developing or dying of cancer in Japan. Jpn J Clin Oncol, 38:571-576, 2008

195. Hirabayashi Y, Katanoda K. Comparison of time trends in multiple myeloma incidence (1973-1997) in East Asia, Europe and United States, from Cancer Incidence in Five Continents, Vols IV-VIII. Jpn J Clin Oncol, 38:720-721, 2008

196. Katanoda K, Qiu D. Comparison of time trends in pancreatic cancer incidence (1973-97) in East Asia, Europe and USA, from Cancer Incidence in Five Continents Vol. IV-VII. Jpn J Clin Oncol, 38:165-166, 2008

197. Katanoda K, Suketomo H. Comparison of time trends in Hodgkin and non-Hodgkin lymphoma incidence (1973-97) in East Asia, Europe and USA, from cancer incidence in five continents Vol. IV-VIII. Jpn J Clin Oncol, 38:391-393, 2008

198. Marugame T, Hirabayashi Y. Comparison of time trends in larynx cancer incidence (1973-97) in East Asia, Europe and USA, from Cancer Incidence in Five Continents, Vols. IV-VIII. Jpn J Clin Oncol, 38:324-325, 2008

199. Marugame T, Matsuda T. Comparison of time trends in kidney cancer incidence (1973-97) in East Asia, Europe and USA, from cancer incidence in five continents, Vols IV-VIII. Jpn J Clin Oncol, 38:508-509, 2008

200. Matsuda T, Katanoda K. Comparison of time trends in bladder cancer incidence (1973-1997) in East Asia, Europe and USA, from Cancer Incidence in Five Continents Vol. IV-VIII. Jpn J Clin Oncol, 38:85-86, 2008

201. Matsuda T, Saika K. Comparison of time trends in testicular cancer incidence (1973-97) in East Asia, Europe and USA, from Cancer Incidence in Five Continents Vols IV-VIII. Jpn J Clin Oncol, 38:578-579, 2008

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