HOME > National
Cancer Center Research Institute > Each Division
> Division of Genome Stability Research >
Biological Roles of Non-coding RNAs in Early Stages
of Colon Carcinogenesis > miR-34a
miR-34a
miRNA-34a
1. Upregulated after exposure to the DNA-damaging
agent, adriamycin
2. Regulated by p53 (Fig. 1)
3. Induces senescence-like cell cycle arrest when over-expressed (Fig. 2)
4. Downregulates the E2F pathway
5. Upregulates p53 and downstream target, p21
6. Suppresses tumor cell growth in vivo (Fig. 3)
7. Downregulated in human colon cancers(~ 36%)
(Tazawa et al., Proc. Natl. Acad. Sci. U S A, 2007)
2. Regulated by p53 (Fig. 1)
3. Induces senescence-like cell cycle arrest when over-expressed (Fig. 2)
4. Downregulates the E2F pathway
5. Upregulates p53 and downstream target, p21
6. Suppresses tumor cell growth in vivo (Fig. 3)
7. Downregulated in human colon cancers(~ 36%)
(Tazawa et al., Proc. Natl. Acad. Sci. U S A, 2007)
Fig. 1. Expression of miR-34a regulated by p53.
Fig. 2 Induction of senescence-like growth arrest by miR-34a.
Fig. 3 Inhibition of tumor cell growth by miR-34a in vivo.
