Dependence receptor

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p53RDL1 was identified as a new p53-target gene, whose product is involved in axon guidance and axonal repulsion. The p53RDL1 gene product contains a cytoplasmic carboxyl-terminal death domain. p53RDL1 mediated p53-dependent apoptosis whereas, when p53RDL1 interacted with its ligand Netrin-1, p53-dependent apoptosis was blocked. The new concept is called "Dependence receptor". Thus, p53RDL1 seems to be a previously un-recognized target of p53 that may define a new pathway for p53-dependent apoptosis. p53 might regulate the survival of damaged cells by balancing the regulation of Netrin-p53RDL1 signaling, and cell death through cleavage of p53RDL1 for apoptosis.