Group for Research of Molecular Functions and Targets
Division of Hematological Malignancy

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Research Staff

Research Activities

Accumulation of mutations in tumor suppressor genes is implicated in pathogenesis of solid tumors. On the other hand, specific chromosome translocations are frequently found in human leukemia and often result in the expression of fusion gene products. These translocations involve genes encoding the AML1/CBFb transcription factor and chromatin regulating factors such as p300/CBP, MOZ, and MLL. Research in the Molecular Oncology Division focuses on the molecular mechanisms of tumorigenesis, especially leukemogenesis through functional analyses of the major suppressor proteins and the leukemia-associated normal and fusion proteins, which can be molecular targets for treatment of leukemia.

Research Projects

• Functional Analysis of the AML1 Complex
• Functional Analysis of Leukemia-associated Fusion Proteins
• Functional Analysis of Leukemia-associated Proto-oncoprotein MLL
• Analysis of Target Genes of Leukemia-associated Chimeric Transcription Factors AML1-MTG8 and FUS-ERG
• Molecular Studies on Chromosomal Translocations in Leukemias
• Positional Cloning of Tumor Suppressors in Endometrial, Esophageal, Breast, and Lung Cancers, and Neuroblastoma
• Genome-Wide Detection of Chromosomal Imbalances in Tumors

List of Papers Published

• papers published in 2007
• papers published in 2006
• papers published in 2005
• papers published in 2004
• papers published in 2003