National Cancer Center Research Institute

Molecular Oncology Division

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Research Staff


Research Activities

Accumulation of mutations in tumor suppressor genes is implicated in pathogenesis of solid tumors. On the other hand, specific chromosome translocations are frequently found in human leukemia and often result in the expression of fusion gene products. These translocations involve genes encoding the AML1/CBFb transcription factor and chromatin regulating factors such as p300/CBP, MOZ, and MLL. Research in the Molecular Oncology Division focuses on the molecular mechanisms of tumorigenesis, especially leukemogenesis through functional analyses of the major suppressor proteins and the leukemia-associated normal and fusion proteins, which can be molecular targets for treatment of leukemia.


Research Projects



List of Papers Published


Last Update:2007/11/01
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