Functional Analysis of the AML1 Complex

---

The AML1 gene is the most frequent target of chromosome translocations in human leukemia. AML1 regulates transcription of certain hematopoietic cell specific genes. We have found that AML1 forms complexes with multiple proteins including histone acetyltransferases MOZ and p300/CBP as well as the heterodimeric partner PEBP2/CBFb. The genes encoding MOZ, p300, CBP and PEBP2b are disrupted and fused in-frame to other genes by chromosome translocations in acute myeloid leukemia. These results suggest that the AML1 complex is a major target of leukemia-associated translocations.