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HOME > National Cancer Center Research Institute > Each Division > Division of Hematological Malignancy > Functional Analysis of Leukemia-associated Fusion Proteins

Functional Analysis of Leukemia-associated Fusion Proteins

Specific chromosome translocations, which involve rearrangements of genes implicated in the regulation of hematopoiesis, are frequently found in cases of human leukemia. To clarify the mechanism of leukemogenesis, we are studying functions of the leukemia associated fusion proteins such as AML1-MTG8, PML-RAR, MOZ-CBP and FUS-ERG that are generated by t(8;21), t(15;17), t(8;16) and t(16;21), respectively. AML1-MTG8 forms complexes with histone deacetylases through interaction with MTGR1/MTG16, and represses AML1-mediated transcription activation. MOZ-CBP also inhibits AML1-mediated transcription while normal MOZ protein strongly activates the transcription.

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