Research Activities
This Division focuses on carcinogenic mechanisms, and it is especially known
for its research in epigenetic mechanisms of carcinogenesis. The Division
developed one of the earliest methods for genome-wide screening method for
differences in DNA methylation, designated as MS-RDA (
Ushijima
et al., 1997 Ushijima,
2005). The method was successfully used not only to identify tumor-suppressor
genes (
Kaneda
et al., 2004), but also to isolate a prognostic marker that is superior
to clinically used ones (
Abe
et al., 2005) and to establish a novel concept of "epigenetic field
for cancerization" that can be utilized as a cancer risk marker (
Maekita
et al., 2006,
Nakajima
et al., 2006,
Ushijima,
2007).
Research Projects
List of Papers Published
