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HOME > National Cancer Center Research Institute > Each Division > Central Animal Division > Molecular Pathological Analysis for Rat Chemical Carcinogenesis Models

Molecular Pathological Analysis for Rat Chemical Carcinogenesis Models

Sequential histopathological analysis in combination with molecular biological techniques of rat chemical carcinogenesis models has been conducted in this laboratory. Inflammation-associated regenerative mucosa with Paneth cell metaplasia observed in early stages of colorectal carcinogenesis was found to possess characteristics of the precursor lesions in rats initiated with 1,2-dimethylhidraszine followed by dextran sodium sulfate treatment. Analyses for early lesions of mammary or thyroid carcinogenesis have also been conducted.

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