Mechanisms of Carcinogenesis by chemicals in food

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Acrylamide has been reported to be formed via baking and frying processes of asparagine- and carbohydrate-rich foods. Acrylamide induces tumors in various organs/tissues in rats and mice, but mechanisms of the carcinogenesis and human health risks from dietary exposure of this chemical have not fully understood. Carcinogenicity and mechanistic studies using hamsters and rats are conducted to clarify species differences of the acrylamide carcinogenesis.