Proteome database (Genome Medicine Database of Japan Proteomics, GeMDBJ Proteomics)

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GeMDBJ Proteomics
In order to contribute to the activity of cancer research by publishing the proteome data in the project, proteome database is developed as a part of Genome Medicine Database of Japan (GeMDBJ Proteomics). GeMDBJ Proteomics includes the quantitative protein expression profiles of clinical samples and clinico-pathological information. The protein expression profiles in the database are generated by 2D-DIGE, and the proteins corresponding to the protein spots are annotated by mass spectrometry. Proteome data of 699 samples are presently available from the database, 1) 9 well-characterized pancreatic cacncer cell lines and 2 normal pancreatic duce cell lines, 2) 53 esophageal cancer tissues and 58 adjacent normal epithelial tissues, 3) 8 Ewing's sarcoma cases with different prognosis, 4) 262 lung adenocarcinoma tissues, 5) 44 tumor tissues of malignancies potentially occurred on pleura, 6) normal and tumor tissues from 59 cases with colorectal cancer, 7) 44 samples of cholangiocarcinoma cells (cell lines, xenografts, tumor tissues), 8) 21 liver cancer cell lines. Data of protein identification are available for 6597 protein spots. GeMDBJ Proteomics will be the largest database for disease proteomics as well as two-dimensional gel electrophoresis.

Reference
Kondo T. Cancer proteome-expression database: Genome Medicine Database of Japan Proteomics. Expert Rev Proteomics. 2010;7(1):21-7.