Cumulated List of Papers Published in 2009

Research Institute: 1. Pathology Division; 2. Biochemistry Division; 3. Chemotherapy Division; 4. Biology Division; 5. Cancer Medicine and Biophysics Division; 6. Growth Factor Division; 7. Molecular Oncology Division; 8. Virology Division; 9. Genetics Division; 10. Carcinogenesis Division; 11. Cancer Pathophysiology Division; 12. Section for Studies on Metastasis; 13. Section for Studies on Host-Immune Response; 14. Central RI Laboratory; 15. Central Animal Laboratory; 16. Cancer Genomics Project; 17. Cancer Prevention Basic Research Project; 18. Cancer Stem Cell Project; 19. Proteome Bioinformatics Project; 20. Tumor Endocrinology Project; 21. Tobacco Control Policy Project; 22. Early Oncogenesis Research Project; 23. Director's Office; 24. Deputy Director's Office; 25. President Emeritus
Research Center for Cancer Prevention and Screening: 26. Epidemiology and Prevention Division
Center for Cancer Control and Information Services: 27. Cancer Information Services and Surveillance Division

1. Pathology Division

1. Akishima-Fukasawa Y, Nakanishi Y, Ino Y, Moriya Y, Kanai Y, Hirohashi S. Prognostic significance of CXCL12 expression in patients with colorectal carcinoma. Am J Clin Pathol, 132:202-210, 2009

2. Arai E, Ushijima S, Fujimoto H, Hosoda F, Shibata T, Kondo T, Yokoi S, Imoto I, Inazawa J, Hirohashi S, Kanai Y. Genome-wide DNA methylation profiles in both precancerous conditions and clear cell renal cell carcinomas are correlated with malignant potential and patient outcome. Carcinogenesis, 30:214-221, 2009

3. Arai E, Ushijima S, Gotoh M, Ojima H, Kosuge T, Hosoda F, Shibata T, Kondo T, Yokoi S, Imoto I, Inazawa J, Hirohashi S, Kanai Y. Genome-wide DNA methylation profiles in liver tissue at the precancerous stage and in hepatocellular carcinoma. Int J Cancer, 125:2854-2862, 2009

4. Deguchi Y, Shimada K, Nara S, Esaki M, Sakamoto Y, Kosuge T, Hiraoka N. Pancreaticojejunostomy with invagination of the punched pancreatic remnant after medial pancreatectomy and enucleation for multiple metastases of renal cell carcinoma: report of a case. Surg Today, 39:1086-1090, 2009

5. Kobayashi Y, Nakanishi Y, Taniguchi H, Sekine S, Igaki H, Tachimori Y, Kato H, Matsubara H, Okazumi S, Shimoda T. Histological diversity in basaloid squamous cell carcinoma of the esophagus. Dis Esophagus, 22:231-238, 2009

6. Nakagawa T, Kanai Y, Komiyama M, Fujimoto H, Kakizoe T. Characteristics of prostate cancers found in specimens removed by radical cystoprostatectomy for bladder cancer and their relationship with serum prostate-specific antigen level. Cancer Sci, 100:1880-1884, 2009

7. Nara S, Onaya H, Hiraoka N, Shimada K, Sano T, Sakamoto Y, Esaki M, Kosuge T. Preoperative evaluation of invasive and noninvasive intraductal papillary-mucinous neoplasms of the pancreas: clinical, radiological, and pathological analysis of 123 cases. Pancreas, 38:8-16, 2009

8. Nara S, Shimada K, Sakamoto Y, Esaki M, Kosuge T, Hiraoka N. Clinical significance of frozen section analysis during resection of intraductal papillary mucinous neoplasm: should a positive pancreatic margin for adenoma or borderline lesion be resected additionally? J Am Coll Surg, 209:614-621, 2009

9. Ojima H, Kanai Y, Iwasaki M, Hiraoka N, Shimada K, Sano T, Sakamoto Y, Esaki M, Kosuge T, Sakamoto M, Hirohashi S. Intraductal carcinoma component as a favorable prognostic factor in biliary tract carcinoma. Cancer Sci, 100:62-70, 2009

10. Saito Y, Suzuki H, Tsugawa H, Nakagawa I, Matsuzaki J, Kanai Y, Hibi T. Chromatin remodeling at Alu repeats by epigenetic treatment activates silenced microRNA-512-5p with downregulation of Mcl-1 in human gastric cancer cells. Oncogene, 28:2738-2744, 2009

11. Sekine S, Nakanishi Y, Ogawa R, Kouda S, Kanai Y. Esophageal melanomas harbor frequent NRAS mutations unlike melanomas of other mucosal sites. Virchows Arch, 454:513-517, 2009

12. Sekine S, Ogawa R, Ito R, Hiraoka N, Mcmanus MT, Kanai Y, Hebrok M. Disruption of Dicer1 induces dysregulated fetal gene expression and promotes hepatocarcinogenesis. Gastroenterology, 136:2304-2315, 2009

13. Sekine S, Ogawa R, Mcmanus MT, Kanai Y, Hebrok M. Dicer is required for proper liver zonation. J Pathol, 219:365-372, 2009

14. Shimada K, Onaya H, Esaki M, Sakamoto Y, Nara S, Kosuge T, Mizuguchi Y, Hiraoka N. Slow growth of small pancreatic carcinoma with a 20-month follow-up. Pancreas, 38:346-349, 2009

15. Shimada K, Sano T, Nara S, Esaki M, Sakamoto Y, Kosuge T, Ojima H. Therapeutic value of lymph node dissection during hepatectomy in patients with intrahepatic cholangiocellular carcinoma with negative lymph node involvement. Surgery, 145:411-416, 2009

16. Yamanashi T, Nakanishi Y, Fujii G, Akishima-Fukasawa Y, Moriya Y, Kanai Y, Watanabe M, Hirohashi S. Podoplanin expression identified in stromal fibroblasts as a favorable prognostic marker in patients with colorectal carcinoma. Oncology, 77:53-62, 2009

17. Yamamoto Y, Shimada K, Sakamoto Y, Esaki M, Nara S, Ban D, Kosuge T, Ojima H. Clinicopathological characteristics of intrahepatic cholangiocellular carcinoma presenting intrahepatic bile duct growth. J Surg Oncol, 99:161-165, 2009

18. Yamazaki K, Takamura M, Masugi Y, Mori T, Du W, Hibi T, Hiraoka N, Ohta T, Ohki M, Hirohashi S, Sakamoto M. Adenylate cyclase-associated protein 1 overexpressed in pancreatic cancers is involved in cancer cell motility. Lab Invest, 89:425-432, 2009

2. Biochemistry Division

19. Fujiwara H, Ogino H, Maeda D, Shirai H, Nozaki T, Kamada K, Jishage K, Tanuma S, Takako T, Ochiya T, Sugimura T, Masutani M. Poly(ADP-ribose) glycohydrolase deficiency sensitizes mouse ES cells to DNA damaging agents. Curr Cancer Drug Targets, 9:953-962, 2009

20. Fukuda H, Takamura-Enya T, Masuda Y, Nohmi T, Seki C, Kamiya K, Sugimura T, Masutani C, Hanaoka F, Nakagama H. Translesional DNA synthesis through a C8-guanyl adduct of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in vitro: REV1 inserts dC opposite the lesion, and DNA polymerase kappa potentially catalyzes extension reaction from the 3'-dC terminus. J Biol Chem, 284:25585-25592, 2009

21. Paramasivam M, Membrino A, Cogoi S, Fukuda H, Nakagama H, Xodo LE. Protein hnRNP A1 and its derivative Up1 unfold quadruplex DNA in the human KRAS promoter: implications for transcription. Nucleic Acids Res, 37:2841-2853, 2009

22. Shibata A, Maeda D, Ogino H, Tsutsumi M, Nohmi T, Nakagama H, Sugimura T, Teraoka H, Masutani M. Role of Parp-1 in suppressing spontaneous deletion mutation in the liver and brain of mice at adolescence and advanced age. Mutat Res, 664:20-27, 2009

23. Shimokawa T, Ogino H, Maeda D, Nakagama H, Sugimura T, Masutani M. Poly(ADP-ribose) preparation using anion-exchange column chromatography. Organic chemistry insights, 2:1-5, 2009

3. Chemotherapy Division

24. Matsubara J, Ono M, Negishi A, Ueno H, Okusaka T, Furuse J, Furuta K, Sugiyama E, Saito Y, Kaniwa N, Sawada J, Honda K, Sakuma T, Chiba T, Saijo N, Hirohashi S, Yamada T. Identification of a predictive biomarker for hematologic toxicities of gemcitabine. J Clin Oncol, 27:2261-2268, 2009

25. Matsubara J, Ono M, Yamada T. Predictive markers for chemotherapy toxicity: an important factor in personalized therapy. EJCMO, 1:1-6, 2009

26. Negishi A, Masuda M, Ono M, Honda K, Shitashige M, Satow R, Sakuma T, Kuwabara H, Nakanishi Y, Kanai Y, Omura K, Hirohashi S, Yamada T. Quantitative proteomics using formalin-fixed paraffin-embedded tissues of oral squamous cell carcinoma. Cancer Sci, 100:1605-1611, 2009

27. Negishi A, Ono M, Handa Y, Kato H, Yamashita K, Honda K, Shitashige M, Satow R, Sakuma T, Kuwabara H, Omura K, Hirohashi S, Yamada T. Large-scale quantitative clinical proteomics by label-free liquid chromatography and mass spectrometry. Cancer Sci, 100:514-519, 2009

28. Ono M, Matsubara J, Honda K, Sakuma T, Hashiguchi T, Nose H, Nakamori S, Okusaka T, Kosuge T, Sata N, Nagai H, Ioka T, Tanaka S, Tsuchida A, Aoki T, Shimahara M, Yasunami Y, Itoi T, Moriyasu F, Negishi A, Kuwabara H, Shoji A, Hirohashi S, Yamada T. Prolyl 4-hydroxylation of a-fibrinogen: a novel protein modification revealed by plasma proteomics. J Biol Chem, 284:29041-29049, 2009

29. Yamamoto S, Tsuda H, Honda K, Onozato K, Takano M, Tamai S, Imoto I, Inazawa J, Yamada T, Matsubara O. Actinin-4 gene amplification in ovarian cancer: a candidate oncogene associated with poor patient prognosis and tumor chemoresistance. Mod Pathol, 22:499-507, 2009

4. Biology Division

30. Anami Y, Iijima T, Suzuki K, Yokota J, Minami Y, Kobayashi H, Satomi K, Nakazato Y, Okada M, Noguchi M. Bronchioloalveolar carcinoma (lepidic growth) component is a more useful prognostic factor than lymph node metastasis. J Thorac Oncol, 4:951-958, 2009

31. Blanco R, Iwakawa R, Tang M, Kohno T, Angulo B, Pio R, Montuenga LM, Minna JD, Yokota J, Sanchez-Cespedes M. A gene-alteration profile of human lung cancer cell lines. Hum Mutat, 30:1-8, 2009

32. Kumamoto K, Fujita K, Kurotani R, Saito M, Unoki M, Hagiwara N, Shiga H, Bowman ED, Yanaihara N, Okamura S, Nagashima M, Miyamoto K, Takenoshita S, Yokota J, Harris CC. ING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression. Int J Cancer, 125:1306-1315, 2009

33. Medina PP, Castillo SD, Blanco S, Sanz-Garcia M, Largo C, Alvarez S, Yokota J, Gonzalez-Neira A, Benitez J, Clevers HC, Cigudosa JC, Lazo PA, Sanchez-Cespedes M. The SRY-HMG box gene, SOX4, is a target of gene amplification at chromosome 6p in lung cancer. Hum Mol Genet, 18:1343-1352, 2009

34. Nakanishi H, Matsumoto S, Iwakawa R, Kohno T, Suzuki K, Tsuta K, Matsuno Y, Noguchi M, Shimizu E, Yokota J. Whole genome comparison of allelic imbalance between noninvasive and invasive small-sized lung adenocarcinomas. Cancer Res, 69:1615-1623, 2009

35. Ohata H, Ota N, Shirouzu M, Yokoyama S, Yokota J, Taya Y, Enari M. Identification of a function-specific mutation of clathrin heavy chain (CHC) required for p53 transactivation. J Mol Biol, 394:460-471, 2009

36. Oliveira C, Sousa S, Pinheiro H, Karam R, Bordeira-Carrico R, Senz J, Kaurah P, Carvalho J, Pereira R, Gusmao L, Wen X, Cipriano MA, Yokota J, Carneiro F, Huntsman D, Seruca R. Quantification of epigenetic and genetic 2nd hits in CDH1 during hereditary diffuse gastric cancer syndrome progression. Gastroenterology, 136:2137-2148, 2009

37. Shiraishi K, Kohno T, Kunitoh H, Watanabe S, Goto K, Nishiwaki Y, Shimada Y, Hirose H, Saito I, Kuchiba A, Yamamoto S, Yokota J. Contribution of nicotine acetylcholine receptor polymorphisms to lung cancer risk in a smoking-independent manner in the Japanese. Carcinogenesis, 30:65-70, 2009

38. Suizu F, Hiramuki Y, Okumura F, Matsuda M, Okumura AJ, Hirata N, Narita M, Kohno T, Yokota J, Bohgaki M, Obuse C, Hatakeyama S, Obata T, Noguchi M. The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt. Dev Cell, 17:800-810, 2009

39. Yoneda M, Suzuki T, Nakamura T, Ajima R, Yoshida Y, Kakuta S, Sudo K, Iwakura Y, Shibutani M, Mitsumori K, Yokota J, Yamamoto T. Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinoma. Cancer Sci, 100:225-232, 2009

5. Cancer Medicine and Biophysics Division

40. Tanikawa C, Furukawa Y, Tanaka N, Arakawa H, Nakamura Y, Matsuda K. XEDAR as a putative colorectal tumor suppressor that mediates p53-regulated anoikis pathway. Oncogene, 28:3081-3092, 2009

6. Growth Factor Division

41. Azuma K, Urano T, Horie-Inoue K, Hayashi S, Sakai R, Ouchi Y, Inoue S. Association of estrogen receptor a and histone deacetylase 6 causes rapid deacetylation of tubulin in breast cancer cells. Cancer Res, 69:2935-2940, 2009

42. Futami H, Sakai R. RET protein promotes non-adherent growth of NB-39-nu neuroblastoma cell line. Cancer Sci, 100:1034-1039, 2009

43. Ikeda J, Oda T, Inoue M, Uekita T, Sakai R, Okumura M, Aozasa K, Morii E. Expression of CUB domain containing protein (CDCP1) is correlated with prognosis and survival of patients with adenocarcinoma of lung. Cancer Sci, 100:429-433, 2009

44. Miyake I, Ohira M, Nakagawara A, Sakai R. Distinct role of ShcC docking protein in the differentiation of neuroblastoma. Oncogene, 28:662-673, 2009

45. Tanaka M, Sasaki K, Kamata R, Hoshino Y, Yanagihara K, Sakai R. A novel RNA-binding protein, Ossa/C9orf10, regulates activity of Src kinases to protect cells from oxidative stress-induced apoptosis. Mol Cell Biol, 29:402-413, 2009

7. Molecular Oncology Division

46. Hibiya K, Katsumoto T, Kondo T, Kitabayashi I, Kudo A. Brpf1, a subunit of the MOZ histone acetyl transferase complex, maintains expression of anterior and posterior Hox genes for proper patterning of craniofacial and caudal skeletons. Dev Biol, 329:176-190, 2009

47. Rokudai S, Aikawa Y, Tagata Y, Tsuchida N, Taya Y, Kitabayashi I. Monocytic leukemia zinc finger (MOZ) interacts with p53 to induce p21 expression and cell-cycle arrest. J Biol Chem, 284:237-244, 2009

48. Yamagata K, Kitabayashi I. Sirt1 physically interacts with Tip60 and negatively regulates Tip60-mediated acetylation of H2AX. Biochim Biophys Res Commun, 390:1355-1360, 2009

8. Virology Division

49. Enomoto M, Goto H, Tomono Y, Kasahara K, Tsujimura K, Kiyono T, Inagaki M. Novel positive feedback loop between Cdk1 and Chk1 in the nucleus during G₂/M transition. J Biol Chem, 284:34223-34230, 2009

50. Ibrahim HR, Kiyono T. Novel anticancer activity of the autocleaved ovotransferrin against human colon and breast cancer cells. J Agric Food Chem, 57:11383-11390, 2009

51. Kawai K, Egawa N, Kiyono T, Kanekura T. Epidermodysplasia-verruciformis-like eruption associated with gamma-papillomavirus infection in a patient with adult T-cell leukemia. Dermatology, 219:274-278, 2009

52. Omi H, Okamoto A, Nikaido T, Urashima M, Kawaguchi R, Umehara N, Sugiura K, Saito M, Kiyono T, Tanaka T. Establishment of an immortalized human extravillous trophoblast cell line by retroviral infection of E6/E7/hTERT and its transcriptional profile during hypoxia and reoxygenation. Int J Mol Med, 23:229-236, 2009

53. Sasaki R, Narisawa-Saito M, Yugawa T, Fujita M, Tashiro H, Katabuchi H, Kiyono T. Oncogenic transformation of human ovarian surface epithelial cells with defined cellular oncogenes. Carcinogenesis, 30:423-431, 2009

54. Shimizu Y, Takeuchi T, Mita S, Mizuguchi K, Kiyono T, Inoue M, Kyo S. Dienogest, a synthetic progestin, inhibits the proliferation of immortalized human endometrial epithelial cells with suppression of cyclin DI gene expression. Mol Hum Reprod, 15:693-701, 2009

55. Sugimoto N, Yoshida K, Tatsumi Y, Yugawa T, Narisawa-Saito M, Waga S, Kiyono T, Fujita M. Redundant and differential regulation of multiple licensing factors ensures prevention of re-replication in normal human cells. J Cell Sci, 122:1184-1191, 2009

56. Yuan H, Ito S, Senga T, Hyodo T, Kiyono T, Kikkawa F, Hamaguchi M. Human papillomavirus type 16 oncoprotein E7 suppresses cadherin-mediated cell adhesion via ERK and AP-1 signaling. Int J Oncol, 35:309-314, 2009

57. Yugawa T, Kiyono T. Molecular mechanisms of cervical carcinogenesis by high-risk human papillomaviruses: novel functions of E6 and E7 oncoproteins. Rev Med Virol, 19:97-113, 2009

9. Genetics Division

58. Fukui T, Kodera Y, Nishio K, Masuda N, Tamura T, Koizumi F. Synergistic interactions between the synthetic retinoid tamibarotene and glucocorticoids in human myeloma cells. Cancer Sci, 100:1137-1143, 2009

59. Isohata N, Aoyagi K, Mabuchi T, Daiko H, Fukaya M, Ohta H, Ogawa K, Yoshida T, Sasaki H. Hedgehog and epithelial-mesenchymal transition signaling in normal and malignant epithelial cells of the esophagus. Int J Cancer, 125:1212-1221, 2009

60. Iwama T, Kuwabara K, Ushiama M, Yoshida T, Sugano K, Ishida H. Identification of somatic APC mutations in recurrent desmoid tumors in a patient with familial adenomatous polyposis to determine actual recurrence of the original tumor or de novo occurrence. Fam Cancer, 8:51-54, 2009

61. Jo A, Tsukimoto I, Ishii E, Asou N, Mitani S, Shimada A, Igarashi T, Hayashi Y, Ichikawa H. Age-associated difference in gene expression of paediatric acute myelomonocytic lineage leukaemia (FAB M4 and M5 subtypes) and its correlation with prognosis. Br J Haematol, 144:917-929, 2009

62. Katoh M. FGFR2 abnormalities underlie a spectrum of bone, skin, and cancer pathologies. J Invest Dermatol, 129:1861-1867, 2009

63. Katoh M, Katoh M. Transcriptional mechanisms of WNT5A based on NF-kB, Hedgehog, TGFb, and Notch signaling cascade. Int J Mol Med, 23:763-769, 2009

64. Katoh M, Katoh M. Integrative genomic analyses of WNT11: transcriptional mechanisms based on canonical WNT signals and GATA transcription factors. Int J Mol Med, 24:247-251, 2009

65. Katoh M, Katoh M. Transcriptional regulation of WNT2B based on the balance of Hedgehog, Notch, BMP and WNT signals. Int J Oncol, 34:1411-1415, 2009

66. Katoh M, Katoh M. Integrative genomic analyses of ZEB2: transcriptional regulation of ZEB2 based on SMADs, ETS1, HIF1a, POU/OCT, and NF-kB. Int J Oncol, 34:1737-1742, 2009

67. Katoh Y, Katoh M. FGFR2-related pathogenesis and FGFR2-targeted therapeutics (Review). Int J Mol Med, 23:307-311, 2009

68. Katoh Y, Katoh M. Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant Hedgehog signaling activation. Curr Mol Med, 9:873-886, 2009

69. Katoh Y, Katoh M. Integrative genomic analyses on GLI1: positive regulation of GLI1 by Hedgehog-GLI, TGFb-Smads, and RTK-PI3K-AKT signals, and negative regulation of GLI1 by Notch-CSL-HES/HEY, and GPCR-Gs-PKA signals. Int J Oncol, 35:187-192, 2009

70. Kawaishi M, Fujiwara Y, Fukui T, Kato T, Yamada K, Ohe Y, Hideo K, Ikuo S, Yamamoto N, Nokihara H, Watabe T, Shimoda Y, Arao T, Nishio K, Tamura T, Koizumi F. Circulating endothelial cells in non-small cell lung cancer patients treated with carboplatin and paclitaxel. J Thorac Oncol, 4:208-213, 2009

71. Li X, Shen Y, Ichikawa H, Antes T, Goldberg GS. Regulation of miRNA expression by Src and contact normalization: effects on nonanchored cell growth and migration. Oncogene, 28:4272-4283, 2009

72. Matsumoto K, Shimizu C, Arao T, Andoh M, Katsumata N, Kohno T, Yonemori K, Koizumi F, Yokote H, Aogi K, Tamura K, Nishio K, Fujiwara Y. Identification of predictive biomarkers for response to trastuzumab using plasma FUCA activity and N-glycan identified by MALDI-TOF-MS. J Proteome Res, 8:457-462, 2009

73. Naruse H, Ikawa N, Yamaguchi K, Nakamura Y, Arai M, Ishioka C, Sugano K, Tamura K, Tomita N, Matsubara N, Yoshida T, Moriya Y, Furukawa Y. Determination of splice-site mutations in Lynch syndrome (hereditary non-polyposis colorectal cancer) patients using functional splicing assay. Fam cancer, 8:509-517, 2009

74. Noda S, Ichikawa H, Miyoshi H. Hematopoietic stem cell aging is associated with fumctional decline and delayed cell cycle progression. Biochem Biophys Res Commun, 383:210-215, 2009

75. Ohta H, Aoyagi K, Fukaya M, Danjoh I, Ohta A, Isohata N, Tani T, Yoshida T, Sasaki H. Cross talk between hedgehog and epithelial-mesenchymal transition pathways in gastric pit cells and in diffuse-type gastric cancers. Br J Cancer, 100:389-398, 2009

76. Oue N, Sentani K, Sakamoto N, Motoshita J, Nishisaka T, Fukuhara T, Matsuura H, Sasaki H, Nakachi K, Yasui W. Characteristic gene expression in stromal cells of gastric cancers among atomic-bomb survivors. Int J Cancer, 124:1112-1121, 2009

77. Saeki N, Usui T, Aoyagi K, Kim DH, Sato M, Mabuchi T, Yanagihara K, Ogawa K, Sakamoto H, Yoshida T, Sasaki H. Distinctive expression and function of four GSDM family genes (GSDMA-D) in normal and malignant upper gastrointestinal epithelium. Genes Chromosomes Cancer, 48:261-271, 2009

78. Saito Y, Sai K, Maekawa K, Kaniwa N, Shirao K, Hamaguchi T, Yamamoto N, Kunitoh H, Ohe Y, Yamada Y, Tamura T, Yoshida T, Minami H, Ohtsu A, Matsumura Y, Saijo N, Sawada J. Close association of UGT1A9 IVS1+399C>T with UGT1A1*28, *6, or *60 haplotype and its apparent influence on 7-ethyl-10-hydroxycamptothecin (SN-38) glucuronidation in Japanese. Drug Metab Dispos, 37:272-276, 2009

79. Sangrajrang S, Sato Y, Sakamoto H, Ohnami S, Laird NM, Khuhaprema T, Paul B, Boffetta P, Yoshida T. Genetic polymorphisms of estrogen metabolizing enzyme and breast cancer risk in Thai women. Int J Cancer, 125:837-843, 2009

80. Sato Y, Laird NM, Nagashima K, Kato R, Hamano T, Yafune A, Kaniwa N, Saito Y, Sugiyama E, Kim S-R, Furuse J, Ishii H, Ueno H, Okusaka T, Saijo N, Sawada J, Yoshida T. A new statistical screening approach for finding pharmacokinetics-related genes in genome-wide studies. Pharmacogenomics J, 9:137-146, 2009

81. Sato Y, Laird N, Suganami H, Hamada C, Niki N, Yoshimura I, Yoshida T. Statistical screening method for genetic factors influencing susceptibility to common diseases in a two-stage genome-wide association study. Stat Appl Genet Mol Biol, 8:1-21, 2009

82. Wu X, Ye Y, Kiemeney LA, Sulem P, Rafnar T, Matullo G, Seminara D, Yoshida T, Saeki N, Andrew AS, Dinney CP, Czerniak B, Zhang Z-F, Kiltie AE, Bishop TD, Vineis P, Porru S, Buntinx F, Kellen E, Zeegers MP, Kumar R, Rudnai P, Gurzau E, Koppova K, Mayordomo JI, Sanchez M, Saez B, Lindblom A, de Verdier P, Steineck G, Mills GB, Schned A, Chang S-C, Lin J, Chang DW, Hale KS, Majewski T, Grossman HB, Thorlacius S, Thorsteinsdottir U, Aben KK, Witjes JA, Stefansson K, Amos CI, Karagas MR, Gu J. Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer. Nat Genet, 41:991-995, 2009

83. Yasen M, Mizushima H, Mogushi K, Obulhasim G, Miyaguchi K, Inoue K, Nakahara I, Ohta T, Aihara A, Tanaka S, Arii S, Tanaka H. Expression of aurora B and alternative variant forms in hepatocellular carcinoma and adjacent tissue. Cancer Sci, 100:472-480, 2009

10. Carcinogenesis Division

84. Akagi I, Miyashita M, Makino H, Nomura T, Hagiwara N, Takahashi K, Cho K, Mishima T, Ishibashi O, Ushijima T, Takizawa T, Tajiri T. Overexpression of PIK3CA is associated with lymph node metastasis in esophageal squamous cell carcinoma. Int J Oncol, 34:767-775, 2009

85. Ando T, Yoshida T, Enomoto S, Asada K, Tatematsu M, Ichinose M, Sugiyama T, Ushijima T. DNA methylation of microRNA genes in gastric mucosae of gastric cancer patients: its possible involvement in the formation of epigenetic field defect. Int J Cancer, 124:2367-2374, 2009

86. Hosoya K, Yamashita S, Ando T, Nakajima T, Itoh F, Ushijima T. Adenomatous polyposis coli 1A is likely to be methylated as a passenger in human gastric carcinogenesis. Cancer Lett, 285:182-189, 2009

87. Nakajima T, Yamashita S, Maekita T, Niwa T, Nakazawa K, Ushijima T. The presence of a methylation fingerprint of Helicobacter pylori infection in human gastric mucosae. Int J Cancer, 124:905-910, 2009

88. Ogasawara N, Tsukamoto T, Mizoshita T, Inada K, Ban H, Kondo S, Takasu S, Ushijima T, Ito K, Ito Y, Ichinose M, Ogawa T, Joh T, Tatematsu M. RUNX3 expression correlates with chief cell differentiation in human gastric cancers. Histol Histopathol, 24:31-40, 2009

89. Oka D, Yamashita S, Tomioka T, Nakanishi Y, Kato H, Kaminishi M, Ushijima T. The presence of aberrant DNA methylation in noncancerous esophageal mucosae in association with smoking history: a target for risk diagnosis and prevention of esophageal cancers. Cancer, 115:3412-3426, 2009

90. Takeshima H, Yamashita S, Shimazu T, Niwa T, Ushijima T. The presence of RNA polymerase II, active or stalled, predicts epigenetic fate of promoter CpG islands. Genome Res, 19:1974-1982, 2009

91. Terada K, Okochi-Takada E, Akashi-Tanaka S, Miyamoto K, Taniyama K, Tsuda H, Asada K, Kaminishi M, Ushijima T. Association between frequent CpG island methylation and HER2 amplification in human breast cancers. Carcinogenesis, 30:466-471, 2009

92. Ushijima T, Yamashita S. Methylation-sensitive representational difference analysis (MS-RDA). Methods Mol Biol, 507:117-130, 2009

93. Yamashita S, Hosoya K, Gyobu K, Takeshima H, Ushijima T. Development of a novel output value for quantitative assessment in methylated DNA immunoprecipitation-CpG island microarray analysis. DNA Res, 16:275-286, 2009

11. Cancer Pathophysiology Division

94. Torashima Y, Uezono Y, Kanaide M, Ando Y, Enjoji A, Kanematsu T, Taniyama K. Presence of GABA_B receptors forming heterodimers with GABA_B1 and GABA_B2 subunits in human lower esophageal sphincter. J Pharmacol Sci, 111:253-259, 2009

95. Yanagita T, Maruta T, Nemoto T, Uezono Y, Matsuo K, Satoh S, Yoshikawa N, Kanai T, Kobayashi H, Wada A. Chronic lithium treatment up-regulates cell surface Nav1.7 sodium channles via inhibition of glycogen synthase kinase-3 in adrenal chromaffin cells: enhancement of Na⁺ influx, Ca²⁺ influx and catecholamine secretion after lithium withdrawal. Neuropharmacology, 57:311-321, 2009

12. Section for Studies on Metastasis

96. Banas A, Teratani T, Yamamoto Y, Tokuhara M, Takeshita F, Osaki M, Kato T, Okochi H, Ochiya T. Rapid hepatic fate specification of adipose-derived stem cells and their therapeutic potential for liver failure. J Gastroenterol Hepatol, 24:70-77, 2009

97. Honma K, Takemasa I, Matoba R, Yamamoto Y, Takeshita F, Mori M, Monden M, Matsubara K, Ochiya T. Screening of potential molecular targets for colorectal cancer therapy. Int J Gen Med, 2:243-257, 2009

98. Kosaka N, Sakamoto H, Terada M, Ochiya T. Pleiotropic function of FGF-4: its role in development and stem cells. Dev Dyn, 238:265-276, 2009

99. Morita S, Hara A, Kojima I, Horii T, Kimura M, Kitamura T, Ochiya T, Nakanishi K, Matoba R, Matsubara K, Hatada I. Dicer is required for maintaining adult pancreas. PLoS ONE, 4:e4212, 2009

100. Pan X-C, Deng Y-B, Sugawara Y, Makuuchi M, Okabe M, Ochiya T, Sugiura W, Kitazawa Y, Fuji N, Li X-K, Miyamoto M, Kimura H. Immunological behavior of enhanced green fluorescent protein (EGFP) as a minor histocompatibility antigen with a special reference to skin isograft and specific regulation of local graft-versus-host reaction (GvHR). Immunol Lett, 123:103-113, 2009

101. Song X, Guo Y, Duo S, Che J, Wu C, Ochiya T, Ding M, Deng H. A mouse model of inducible liver injury caused by tet-on regulated urokinase for studies of hepatocyte transplantation. Am J Pathol, 175:1975-1983, 2009

102. Takeshita F, Hokaiwado N, Honma K, Banas A, Ochiya T. Local and systemic delivery of siRNAs for oligonucleotide therapy. Methods Mol Biol, 487:83-92, 2009

103. Yamamoto Y, Kosaka N, Tanaka M, Koizumi F, Kanai Y, Mizutani T, Murakami Y, Kuroda M, Miyajima A, Kato T, Ochiya T. MicroRNA-500 as a potential diagnostic marker for hepatocellular carcinoma. Biomarkers, 14:529-538, 2009

13. Section for Studies on Host-Immune Response

104. Hara H, Kobayashi A, Narumi K, Kondoh A, Yoshida K, Nishimoto T, Ohashi M, Higashihara E, Ohnami S, Yoshida T, Aoki K. Intratumoral interferon-a gene transfer enhances tumor immunity after allogeneic hematopoietic stem cell transplantation. Cancer Immunol Immunother, 58:1007-1021, 2009

105. Kawamura T, Takeda K, Kaneda H, Matsumoto H, Hayakawa Y, Raulet DH, Ikarashi Y, Kronenberg M, Yagita H, Kinoshita K, Abo T, Okumura K, Smyth MJ. NKG2A inhibits invariant NKT cell activation in hepatic injury. J Immunol, 182:250-258, 2009

106. Nishimoto T, Yoshida K, Miura Y, Kobayashi A, Hara H, Ohnami S, Kurisu K, Yoshida T, Aoki K. Oncolytic virus therapy for pancreatic cancer using the adenovirus library displaying random peptides on the fiber knob. Gene Ther, 16:669-680, 2009

107. Yoshida M, Matsui Y, Iizuka A, Ikarashi Y. G₂-phase arrest through p21(WAF1/Cip1) induction and cdc2 repression by gnidimacrin in human hepatoma HLE cells. Anticancer Res, 29:1349-1354, 2009

14. Central RI Laboratory

15. Central Animal Laboratory

108. Cho Y-M, Imai T, Hasumura M, Watanabe N, Ushijima T, Hirose M, Nishikawa A. Increased H-ras mutation frequency in mammary tumors of rats initiated with N-methyl-N-nitrosourea (MNU) and treated with acrylamide. J Toxicol Sci, 34:407-412, 2009

109. Imai T, Hasumura M, Cho Y-M, Ota Y, Takami S, Hirose M, Nishikawa A. Inhibitory effects of aminoguanidine on thyroid follicular carcinoma development in inflamed capsular regions of rats treated with sulfadimethoxine after N-bis(2-hydroxypropyl)nitrosamine-initiation. Cancer Sci, 100:1794-1800, 2009

16. Cancer Genomics Project

110. Akashi-Tanaka S, Shimizu C, Ando M, Shibata T, Katsumata N, Kouno T, Terada K, Shien T, Yoshida M, Hojo T, Kinoshita T, Fujiwara Y, Yoshimura K. 21-gene expression profile assay on core needle biopsies predicts responses to neoadjuvant endocrine therapy in breast cancer patients. Breast, 18:171-174, 2009

111. Hasebe T, Okada N, Tamura N, Houjoh T, Akashi-Tanaka S, Tsuda H, Shibata T, Sasajima Y, Iwasaki M, Kinoshita T. p53 expression in tumor stromal fibroblasts is associated with the outcome of patients with invasive ductal carcinoma of the breast. Cancer Sci, 100:2101-2108, 2009

112. Kubo T, Kuroda Y, Kokubu A, Hosoda F, Arai Y, Hiraoka N, Hirohashi S, Shibata T. Resequencing analysis of the human tyrosine kinase gene family in pancreatic cancer. Pancreas, 38:e200-e206, 2009

113. Kubo T, Kuroda Y, Shimizu H, Kokubu A, Okada N, Hosoda F, Arai Y, Nakamura Y, Taniguchi H, Yanagihara K, Imoto I, Inazawa J, Hirohashi S, Shibata T. Resequencing and copy number analysis of the human tyrosine kinase gene family in poorly differentiated gastric cancer. Carcinogenesis, 30:1857-1864, 2009

114. Nakamura Y, Migita T, Hosoda F, Okada N, Gotoh M, Arai Y, Fukushima M, Ohki M, Miyata S, Takeuchi K, Imoto I, Katai H, Yamaguchi T, Inazawa J, Hirohashi S, Ishikawa Y, Shibata T. Kruppel-like factor 12 plays a significant role in poorly differentiated gastric cancer progression. Int J Cancer, 125:1859-1867, 2009

115.Shibata T, Kokubu A, Tsuta K, Hirohashi S. Oncogenic mutation of PIK3CA in small cell lung carcinoma: a potential therapeutic target pathway for chemotherapy-resistant lung cancer. Cancer Lett, 283:203-211, 2009

116. Tamura N, Hasebe T, Okada N, Houjoh T, Akashi-Tanaka S, Shimizu C, Shibata T, Sasajima Y, Iwasaki M, Kinoshita T. Tumor histology in lymph vessels and lymph nodes for the accurate prediction of outcome among breast cancer patients treated with neoadjuvant chemotherapy. Cancer Sci, 100:1823-1833, 2009

117. Yoshikawa D, Ojima H, Kokubu A, Ochiya T, Kasai S, Hirohashi S, Shibata T. Vandetanib (ZD6474), an inhibitor of VEGFR and EGFR signalling, as a novel molecular-targeted therapy against cholangiocarcinoma. Br J Cancer, 100:1257-1266, 2009

17. Cancer Prevention Basic Research Project

118. Kawanishi M, Nishida H, Totsuka Y, Nishimura K, Wakabayashi K, Yagi T. Mutagenic specificity of N-nitrosotaurocholic acid in supF shuttle vector plasmids. Genes Environ, 31:9-14, 2009

119. Matsuda Y, Takeuchi H, Yokohira M, Saoo K, Hosokawa K, Yamakawa K, Zeng Y, Totsuka Y, Wakabayashi K, Imaida K. Enhancing effects of a high fat diet on 2-amino-3, 8-dimethylimidazo[4,5-f] quinoxaline-induced lung tumorigenesis in female A/J mice. Mol Med Rep, 2:701-706, 2009

120. Mutoh M, Komiya M, Teraoka N, Ueno T, Takahashi M, Kitahashi T, Sugimura T, Wakabayashi K. Overexpression of low-density lipoprotein receptor and lipid accumulation in intestinal polyps in Min mice. Int J Cancer, 125:2505-2510, 2009

121. Nishigaki R, Watanabe T, Kajimoto T, Tada A, Takamura-Enya T, Enomoto S, Nukaya H, Terao Y, Muroyama A, Ozeki M, Node M, Hasei T, Totsuka Y, Wakabayashi K. Isolation and identification of a novel aromatic amine mutagen produced by the Maillard reaction. Chem Res Toxicol, 22:1588-1593, 2009

122. Nishimura K, Totsuka Y, Higuchi T, Kawahara N, Sugimura T, Wakabayashi K. Analysis of an RNA adduct formed from aminophenylnorharman. Nucleic Acids Symp Ser (Oxf), 53:211-212, 2009

123. Ohe T, Suzuki A, Watanabe T, Hasei T, Nukaya H, Totsuka Y, Wakabayashi K. Induction of SCEs in CHL cells by dichlorobiphenyl derivative water pollutants, 2-phenylbenzotriazole (PBTA) congeners and river water concentrates. Mutat Res, 678:38-42, 2009

124. Ozeki M, Muroyama A, Kajimoto T, Watanabe T, Wakabayashi K, Node M. Synthesis of a new mutagenic benzoazepinoquinolinone derivative. Synlett, 11:1781-1784, 2009

125. Takasuka N, Takahashi M, Hori Y, Kitahashi T, Iigo M, Imai T, Yoshimi N, Sugimura T, Wakabayashi K. Promotion of mouse two-stage skin carcinogenesis by diacylglycerol-rich edible oil. Cancer Lett, 275:150-157, 2009

126. Totsuka Y, Higuchi T, Imai T, Nishikawa A, Nohmi T, Kato T, Masuda S, Kinae N, Hiyoshi K, Ogo S, Kawanishi M, Yagi T, Ichinose T, Fukumori N, Watanabe M, Sugimura T, Wakabayashi K. Genotoxicity of nano/microparticles in in vitro micronuclei, in vivo comet and mutation assay systems. Part Fibre Toxicol, 6:23, 2009

127. Wakabayashi K. Chemical and biological approaches for detecting environmental causes of cancer. Genes Environ, 31:87-96, 2009

128. Yamamoto M, Nakano T, Matsushima-Hibiya Y, Totsuka Y, Takahashi-Nakaguchi A, Matsumoto Y, Sugimura T, Wakabayashi K. Molecular cloning of apoptosis-inducing Pierisin-like proteins, from two species of white butterfly, Pieris melete and Aporia crataegi. Comp Biochem Physiol B Biochem Mol Biol, 154:326-333, 2009

18. Cancer Stem Cell Project

129. Maida Y, Yasukawa M, Furuuchi M, Lassmann T, Possemato R, Okamoto N, Kasim V, Hayashizaki Y, Hahn WC, Masutomi K. An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA. Nature, 461:230-235, 2009

19. Proteome Bioinformatics Project

130. Harada C, Tajima H, Hirohashi S, Kondo T. Toward high performance western blotting using vacuum-driven system and laser scanner; comparison between two signal detection methods based on chemiluminescent and immunofluorescent imaging. J Electrophoresis, 53:63-66, 2009

131. Kikuta K, Gotoh M, Kanda T, Tochigi N, Shimoda T, Hasegawa T, Katai H, Shimada Y, Suehara Y, Kawai A, Hirohashi S, Kondo T. Pfetin as a prognostic biomarker in gastrointestinal stromal tumor: novel monoclonal antibody and external validation study in multiple clinical facilities. Jpn J Clin Oncol, 40:60-72, 2009

132. Kikuta K, Tochigi N, Shimoda T, Yabe H, Morioka H, Toyama Y, Hosono A, Beppu Y, Kawai A, Hirohashi S, Kondo T. Nucleophosmin as a candidate prognostic biomarker of Ewing's sarcoma revealed by proteomics. Clin Cancer Res, 15:2885-2894, 2009

133. Kikuta K, Tsunehiro Y, Yoshida A, Tochigi N, Hirohashi S, Kawai A, Kondo T. Proteome expression database of ewing sarcoma: a segment of the Genome Medicine Database of Japan Proteomics. J Proteomics Bioinform, 2:500-504, 2009

134. Kondo T, Hirohashi S. Application of 2D-DIGE in cancer proteomics toward personalized medicine. Methods Mol Biol, 577:135-154, 2009

135. Kosaihira S, Tsunehiro Y, Tsuta K, Tochigi N, Gemma A, Hirohashi S, Kondo T. Proteome expression database of lung adenocarcinoma: a segment of the genome medicine database of Japan proteomics. J Proteomics Bioinform, 2:463-465, 2009

136. Suehara Y, Kikuta K, Nakayama R, Fujii K, Ichikawa H, Shibata T, Seki K, Hasegawa T, Gotoh M, Tochigi N, Shimoda T, Shimada Y, Sano T, Beppu Y, Kurosawa H, Hirohashi S, Kondoh T. Anatomic site-specifec proteomic signatures of gastrointestinal stromal tumors. Proteomics Clin Appl, 3:584-596, 2009

137. Suehara Y, Kikuta K, Nakayama R, Tochigi N, Seki K, Ichikawa H, Fujii K, Hasegawa T, Shimoda T, Kurosawa H, Chuman H, Beppu Y, Kawai A, Hirohashi S, Kondoh T. GST-P1 as a histological biomarker of synovial sarcoma revealed by proteomics. Proteomics Clin Appl, 3:623-634, 2009

138. Uemura N, Nakanishi Y, Kato H, Nagino M, Hirohashi S, Kondo T. Antibody-based proteomics for esophageal cancer: identification of proteins in the nuclear factor-kB pathway and mitotic checkpoint. Cancer Sci, 100:1612-1622, 2009

139. Uemura N, Nakanishi Y, Kato H, Saito S, Nagino M, Hirohashi S, Kondoh T. Transglutaminase 3 as a prognostic biomarker in esophageal cancer revealed by proteomics. Int J Cancer, 124:2106-2115, 2009

140. Yamada M, Fujii K, Koyama K, Hirohashi S, Kondo T. The proteomic profile of pancreatic cancer cell lines corresponding to carcinogenesis and metastasis. J Proteomics Bioinform, 2:1-18, 2009

20. Tumor Endocrinology Project

141. Kitoh A, Ono M, Naoe Y, Ohkura N, Yamaguchi T, Yaguchi H, Kitabayashi I, Tsukada T, Nomura T, Miyachi Y, Taniuchi I, Sakaguchi S. Indispensable role of the Runx1-Cbfb transcription complex for in vivo-suppressive function of FoxP3⁺ regulatory T cells. Immunity, 31:609-620, 2009

142. Okamoto T, Iihara M, Obara T, Tsukada T. Parathyroid carcinoma: etiology, diagnosis, and treament. World J Surg, 33:2343-2354, 2009

143. Tsukada T, Nagamura Y, Ohkura N. MEN1 gene and its mutations: basic and clinical implications. Cancer Sci, 100:209-215, 2009

144. Xue L, Yu D, Furusawa Y, Cao J, Okayasu R, Fan S. ATM-dependent hyper-radiosensitivity in mammalian cells irradiated by heavy ions. Int J Radiat Oncol Biol Phys, 75:235-243, 2009

145. Xue L, Yu D, Furusawa Y, Okayasu R, Tong J, Cao J, Fan S. Regulation of ATM in DNA double strand break repair accounts for the radiosensitivity in human cells exposed to high linear energy transfer ionizing radiation. Mutat Res, 670:15-23, 2009

21. Tobacco Control Policy Project

22. Early Oncogenesis Research Project

146. Endo H, Hosono K, Fujusawa T, Takahashi H, Sugiyama M, Yoneda K, Nozaki Y, Fujita K, Yoneda M, Inamori M, Wada K, Nakagama H, Nakajima A. Involvement of JNK pathway in the promotion of the early stage of colorectal carcinogenesis under high-fat dietary conditions. Gut, 58:1637-1643, 2009

147. Kato M, Sanada M, Kato I, Sato Y, Takita J, Takeuchi K, Niwa A, Chen Y, Nakazaki K, Nomoto J, Asakura Y, Muto S, Tamura A, Iio M, Akatsuka Y, Hayashi Y, Mori H, Igarashi T, Kurokawa M, Chiba S, Mori S, Ishikawa Y, Okamoto K, Tobitani K, Nakagama H, Nakahata T, Yoshino T, Kobayashi Y, Ogawa S. Frequent inactivation of A20 in B-cell lymphomas. Nature, 459:712-716, 2009

148. Li H, Okamoto K, Peart MJ, Prives C. Lysine-independent turnover of cyclin G1 can be stabilized by B'a subunits of protein phosphatase 2A. Mol Cell Biol, 29:919-928, 2009

149. Ohtsubo C, Shiokawa D, Kodama M, Gaiddon C, Nakagama H, Jochemsen AG, Taya Y, Okamoto K. Cytoplasmic tethering is involved in synergistic inhibition of p53 by Mdmx and Mdm2. Cancer Sci, 100:1291-1299, 2009

150. Okamoto K, Taya Y, Nakagama H. Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase. FEBS Lett, 583:2710-2714, 2009

151. Sugiyama M, Takahashi H, Hosono K, Endo H, Kato S, Yoneda K, Nozaki Y, Fujita K, Yoneda M, Wada K, Nakagama H, Nakajima A. Adiponectin inhibits colorectal cancer cell growth through the AMPK/mTOR pathway. Int J Oncol, 34:339-344, 2009

152. Takahashi H, Takayama T, Hosono K, Yoneda K, Endo H, Nozaki Y, Fujita K, Yoneda M, Inamori M, Abe Y, Kobayashi N, Kirikoshi H, Kubota K, Saito S, Nakagama H, Nakajima A. Correlation of the plasma level of insulin-like growth factor-1 with the number of aberrant crypt foci in male individuals. Mol Med Rep, 2:339-343, 2009

153. Takahashi H, Takayama T, Yoneda K, Endo H, Iida H, Sugiyama M, Fujita K,Yoneda M, Inamori M, Abe Y, Saito S, Wada K, Nakagama H, Nakajima A. Association of visceral fat accumulation and plasma adiponectin with rectal dysplastic aberrant crypt foci in a clinical population. Cancer Sci, 100:29-32, 2009

154. Uchida S, Yoshioka K, Kizu R, Nakagama H, Matsunaga T, Ishizaka Y, Poon RYC, Yamashita K. Stress-activated mitogen-activated protein kinases c-Jun NH₂-terminal kinase and p38 target Cdc25B for degradation. Cancer Res, 69:6438-6444, 2009

23. Director's Office

24. Deputy Director's Office

25. President Emeritus

155. Sugimura T. Obituary: Takahashi Tsuruo. Mol Cancer Ther, 8:989-990, 2009

26. Epidemiology and Prevention Division

156. Akhter M, Iwasaki M, Yamaji T, Sasazuki S, Tsugane S. Dietary isoflavone and the risk of colorectal adenoma: a case-control study in Japan. Br J Cancer, 100:1812-1816, 2009

157. Goto M, Shinmura K, Igarashi H, Kobayashi M, Konno H, Yamada H, Iwaizumi M, Kageyama S, Tsuneyoshi T, Tsugane S, Sugimura H. Altered expression of the human base excision repair gene NTH1 in gastric cancer. Carcinogenesis, 30:1345-1352, 2009

158. Goto M, Shinmura K, Tao H, Tsugane S, Sugimura H. Three novel genetic polymorphisms in the promoter region of the human base excision repair gene NEIL1 in gastric cancer patients. World J Gastrointest Oncol, 1, 2009

159. Honjo K, Iso H, Ikeda A, Inoue M, Tsugane S, the JPHC Study Group. Education level and physical functional limitations among Japanese community residents-gender difference in prognosis from stroke. BMC Public Health, 9:131, 2009

160. Ikeda A, Iso H, Kawachi I, Yamagishi K, Inoue M, Tsugane S, the JPHC Study Group. Living arrangement and coronary heart disease: the JPHC study. Heart, 95:577-583, 2009

161. Ikeda A, Iso H, Yamagishi K, Inoue M, Tsugane S. Blood pressure and the risk of stroke, cardiovascular disease, and all-cause mortality among Japanese: the JPHC Study. Am J Hypertens, 22:273-280, 2009

162. Ikehara S, Iso H, Yamagishi K, Yamamoto S, Inoue M, Tsugane S, the JPHC Study Group. Alcohol consumption, social support, and risk of stroke and coronary heart disease among Japanese men: the JPHC Study. Alcohol Clin Exp Res, 33:1025-1032, 2009

163. Inoue M, Kurahashi N, Iwasaki M, Shimazu T, Tanaka Y, Mizokami M, Tsugane S, the Japan Public Health Center-Based Prospective Study Group. Effect of coffee and green tea consumption on the risk of liver cancer: cohort analysis by hepatitis virus infection status. Cancer Epidemiol Biomarkers Prev, 18:1746-1753, 2009

164. Inoue M, Kurahashi N, Iwasaki M, Tanaka Y, Mizokami M, Noda M, Tsugane S, the Japan Public Health Center-Based Prospective Study Group. Metabolic factors and subsequent risk of hepatocellular carcinoma by hepatitis virus infection status: a large-scale population-based cohort study of Japanese men and women (JPHC Study Cohort II). Cancer Causes Control, 20:741-750, 2009

165. Inoue M, Noda M, Kurahashi N, Iwasaki M, Sasazuki S, Iso H, Tsugane S, the Japan Public Health Center-based Prospective Study Group. Impact of metabolic factors on subsequent cancer risk: results from a large-scale population-based cohort study in Japan. Eur J Cancer Prev, 18:240-247, 2009

166. Inoue M, Sasazuki S, Wakai K, Suzuki T, Matsuo K, Shimazu T, Tsuji I, Tanaka K, Mizoue T, Nagata C, Tamakoshi A, Sawada N, Tsugane S, the Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan. Green tea consumption and gastric cancer in Japanese: a pooled analysis of six cohort studies. Gut, 58:1323-1332, 2009

167. Ishiguro S, Inoue M, Tanaka Y, Mizokami M, Iwasaki M, Tsugane S, the JPHC Study Group. Serum aminotransferase level and the risk of hepatocellular carcinoma: a population-based cohort study in Japan. Eur J Cancer Prev, 18:26-32, 2009

168. Ishiguro S, Sasazuki S, Inoue M, Kurahashi N, Iwasaki M, Tsugane S, the JPHC Study Group. Effect of alcohol consumption, cigarette smoking and flushing response on esophageal cancer risk: a population-based cohort study (JPHC study). Cancer Lett, 275:240-246, 2009

169. Ishihara J, Iwasaki M, Kunieda CM, Hamada GS, Tsugane S. Food frequency questionnaire is a valid tool in the nutritional assessment of Brazilian women of diverse ethnicity. Asia Pac J Clin Nutr, 18:76-80, 2009

170. Ishihara J, Todoriki H, Inoue M, Tsugane S, the JPHC FFQ Validation Study Group. Validity of a self-administered food-frequency questionnaire in the estimation of amino acid intake. Br J Nutr, 101:1393-1399, 2009

171. Iso H, Ikeda A, Inoue M, Sato S, Tsugane S, the JPHC Study Group. Serum cholesterol levels in relation to the incidence of cancer: the JPHC study cohorts. Int J Cancer, 125:2679-2686, 2009

172. Itoh H, Iwasaki M, Hanaoka T, Kasuga Y, Yokoyama S, Onuma H, Nishimura H, Kusama R, Tsugane S. Serum organochlorines and breast cancer risk in Japanese women: a case-control study. Cancer Causes Control, 20:567-580, 2009

173. Itoh H, Iwasaki M, Hanaoka T, Sasaki H, Tanaka T, Tsugane S. Urinary phthalate monoesters and endometriosis in infertile Japanese women. Sci Total Environ, 408:37-42, 2009

174. Iwasaki M, Hamada GS, Nishimoto IN, Netto MM, Motola J Jr, Laginha FM, Kasuga Y, Yokoyama S, Onuma H, Nishimura H, Kusama R, Kobayashi M, Ishihara J, Yamamoto S, Hanaoka T, Tsugane S. Dietary isoflavone intake and breast cancer risk in case-control studiesin Japanese, Japanese Brazilians, and non-Japanese Brazilians. Breast Cancer Res Treat, 116:401-411, 2009

175. Iwasaki M, Hamada GS, Nishimoto IN, Netto MM, Motola J Jr, Laginha FM, Kasuga Y, Yokoyama S, Onuma H, Nishimura H, Kusama R, Kobayashi M, Ishihara J, Yamamoto S, Hanaoka T, Tsugane S. Isoflavone, polymorphisms in estrogen receptor genes and breast cancer risk in case-control studies in Japanese, Japanese Brazilians and non-Japanese Brazilians. Cancer Sci, 100:927-933, 2009

176. Kato M, Noda M, Inoue M, Kadowaki T, Tsugane S, the JPHC Study Group. Psychological factors, coffee and risk of diabetes mellitus among middle-aged Japanese: a population-based prospective study in the JPHC study cohort. Endocr J, 56:459-468, 2009

177. Kirii K, Mizoue T, Iso H, Takahashi Y, Kato M, Inoue M, Noda M, Tsugane S, the Japan Public Health Center-based Prospective Study Group. Calcium, vitamin D and dairy intake in relation to type 2 diabetes risk in a Japanese cohort. Diabetologia, 52:2542-2550, 2009

178. Kobayashi M, Otani T, Iwasaki M, Natsukawa S, Shaura K, Koizumi Y, Kasuga Y, Sakamoto H, Yoshida T, Tsugane S. Association between dietary heterocyclic amine levels, genetic polymorphisms of NAT2, CYP1A1, and CYP1A2 and risk of stomach cancer: a hospital-based case-control study in Japan. Gastric Cancer, 12:198-205, 2009

179. Kobayashi M, Otani T, Iwasaki M, Natsukawa S, Shaura K, Koizumi Y, Kasuga Y, Sakamoto H, Yoshida T, Tsugane S. Association between dietary heterocyclic amine levels, genetic polymorphisms of NAT2, CYP1A1, and CYP1A2 and risk of colorectal cancer: a hospital-based case-control study in Japan. Scand J Gastroenterol, 44:952-959, 2009

180. Kurahashi N, Inoue M, Iwasaki M, Sasazuki S, Tsugane S, the Japan Public Health Center (JPHC) Study Group. Coffee, green tea, and caffeine consumption and subsequent risk of bladder cancer in relation to smoking status: a prospective study in Japan. Cancer Sci, 100:284-291, 2009

181. Kurahashi N, Inoue M, Iwasaki M, Tanaka Y, Mizokami M, Tsugane S, the JPHC Study Group. Vegetable, fruit and antioxidant nutrient consumption and subsequent risk of hepatocellular carcinoma: a prospective cohort study in Japan. Br J Cancer, 100:181-184, 2009

182. Kurahashi N, Inoue M, Iwasaki M, Tanaka Y, Mizokami M, Tsugane S, the JPHC Study Group. Isoflavone consumption and subsequent risk of hepatocellular carcinoma in a population-based prospective cohort of Japanese men and women. Int J Cancer, 124:1644-1649, 2009

183. Ma E, Iwasaki M, Ishihara J, Hamada GS, Nishimoto IN, Carvalho SMT, Motola JJ, Laginha FM, Tsugane S. Dietary intake of folate, vitamin B6, and vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Brazilian women. BMC Cancer, 9:122, 2009

184. Ma E, Iwasaki M, Kobayashi M, Kasuga Y, Yokoyama S, Onuma H, Nishimura H, Kusama R, Tsugane S. Dietary intake of folate, vitamin B2, vitamin B6, vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Japan. Nutr Cancer, 61:447-456, 2009

185. Matsushita Y, Mizoue T, Takahashi Y, Isogawa A, Kato M, Inoue M, Noda M, Tsugane S, the JPHC Study Group. Taste preferences and body weight change in Japanese adults: the JPHC Study. Int J Obes, 33:1191-1197, 2009

186. Nakamura K, Kurahashi N, Ishihara J, Inoue M, Tsugane S, the Japan Public Health Centre-based Prospective Study Group. Calcium intake and the 10-year incidence of self-reported vertebral fractures in women and men: the Japan Public Health Centre-based Prospective Study. Br J Nutr, 101:285-294, 2009

187. Noda H, Iso H, Saito I, Konishi M, Inoue M, Tsugane S, the JPHC Study Group. The impact of the metabolic syndrome and its components on the incidence of ischemic heart disease and stroke: the Japan public health center-based study. Hypertens Res, 32:289-298, 2009

188. Saito I, Iso H, Kokubo Y, Inoue M, Tsugane S. Metabolic syndrome and all-cause and cardiovascular disease mortality: Japan Public Health Center-Based Prospective (JPHC) Study. Circ J, 73:878-884, 2009

189. Saito I, Konishi M, Iso H, Inoue M, Tsugane S. Impact of weight change on specific-cause mortality among middle-aged Japanese individuals. J Epidemiol Community Health, 63:447-454, 2009

190. Sharma S, Iwasaki M, Kunieda C, Cao X, Ishihara J, Hamada G, Miyajima NT, Tsugane S, Le Marchand L. Development of a quantitative food frequency questionnaire for assessing food, nutrient, and heterocyclic aromatic amines intake in Japanese Brazilians for a colorectal adenoma case-control study. Int J Food Sci Nutr, 60:128-139, 2009

191. Shimada N, Iwasaki M, Kasuga Y, Yokoyama S, Onuma H, Nishimura H, Kusama R, Hamada GS, Nishimoto IN, Iyeyasu H, Motola J Jr, Laginha FM, Kurahashi N, Tsugane S. Genetic polymorphisms in estrogen metabolism and breast cancer risk in case-control studies in Japanese, Japanese Brazilians and non-Japanese Brazilians. J Hum Genet, 54:209-215, 2009

192. Shimazu T, Kuriyama S, Ohmori-Matsuda K, Kikuchi N, Nakaya N, Tsuji I. Increase in body mass index category since age 20 years and all-cause mortality: a prospective cohort study (the Ohsaki Study). Int J Obes (Lond), 33:490-496, 2009

193. Shirai K, Iso H, Ohira T, Ikeda A, Noda H, Honjo K, Inoue M, Tsugane S, the Japan Public Health Center-Based Study Group. Perceived level of life enjoyment and risks of cardiovascular disease incidence and mortality: the Japan public health center-based study. Circulation, 120:956-963, 2009

194. Suzuki R, Orsini N, Saji S, Key TJ, Wolk A. Body weight and incidence of breast cancer defined by estrogen and progesterone receptor status: a meta-analysis. Int J Cancer, 124:698-712, 2009

195. Tanaka S, Yamamoto S, Inoue M, Iwasaki M, Sasazuki S, Iso H, Tsugane S, the JPHC Study Group. Projecting the probability of survival free from cacer and cardiovascular incidence through lifestyle modification in Japan. Prev Med, 48:128-133, 2009

196. Tatemichi M, Iwasaki M, Sasazuki S, Tsugane S. Association between polymorphisms in glutathione S-transferase Mu3 and IgG titer levels in serum against Helicobacter pylori. J Hum Genet, 54:557-563, 2009

197. Tatemichi M, Sasazuki S, Inoue M, Tsugane S, the JPHC Study Group. Clinical significance of IgG antibody titer against Helicobacter pylori. Helicobacter, 14:231-236, 2009

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27. Cancer Information Services and Surveillance Division

201. Boku N, Yamamoto S, Fukuda H, Shirao K, Doi T, Sawaki A, Koizumi W, Saito H, Yamaguchi K, Takiuchi H, Nasu J, Ohtsu A, Gastrointestinal Oncology Study Group of the Japan Clinical Oncology Group. Fluorouracil versus combination of irinotecan plus cisplatin versus S-1 in metastatic gastric cancer: a randomised phase 3 study. Lancet Oncol, 10:1063-1069, 2009

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