Cumulated List of Papers Published in 2010

Research Institute: 1. Pathology Division; 2. Biochemistry Division; 3. Chemotherapy Division; 4. Biology Division; 5. Cancer Medicine and Biophysics Division; 6. Growth Factor Division; 7. Molecular Oncology Division; 8. Virology Division; 9. Genetics Division; 10. Carcinogenesis Division; 11. Cancer Pathophysiology Division; 12. Section for Studies on Metastasis; 13. Section for Studies on Host-Immune Response; 14. Central RI Laboratory; 15. Central Animal Laboratory; 16. Cancer Genomics Project; 17. Cancer Prevention Basic Research Project; 18. Cancer Stem Cell Project; 19. Proteome Bioinformatics Project; 20. Tumor Endocrinology Project; 21. Tobacco Control Policy Project; 22. Early Oncogenesis Research Project; 23. Director's Office; 24. Deputy Director's Office; 25. President Emeritus

1. Pathology Division

1. Arai E, Kanai Y. DNA methylation profiles in precancerous tissue and cancers: carcinogenetic risk estimation and prognostication based on DNA methylation status. Epigenomics, 2:467-481, 2010

2. Ban D, Shimada K, Sekine S, Sakamoto Y, Kosuge T, Kanai Y, Hiraoka N. Pancreatic ducts as an important route of tumor extension for acinar cell carcinoma of the pancreas. Am J Surg Pathol, 34:1025-1036, 2010

3. Kanai Y. Genome-wide DNA methylation profiles in precancerous conditions and cancers. Cancer Sci, 101:36-45, 2010

4. Nishiyama N, Arai E, Chihara Y, Fujimoto H, Hosoda F, Shibata T, Kondo T, Tsukamoto T, Yokoi S, Imoto I, Inazawa J, Hirohashi S, Kanai Y. Genome-wide DNA methylation profiles in urothelial carcinomas and urothelia at the precancerous stage. Cancer Sci, 101:231-240, 2010

5. Okamura J, Sekine S, Nara S, Ojima H, Shimada K, Kanai Y, Hiraoka N. Intraductal carcinosarcoma with a heterologous mesenchymal component originating in intraductal papillary-mucinous carcinoma (IPMC) of the pancreas with both carcinoma and osteosarcoma cells arising from IPMC cells. J Clin Pathol, 63:266-269, 2010

6. Yamamoto Y, Ojima H, Shimada K, Onaya H, Hiraoka N, Mizuguchi Y, Kosuge T, Kanai Y. Long-term recurrence-free survival in a patient with primary hepatic carcinosarcoma: case report with a literature review. Jpn J Clin Oncol, 40:166-173, 2010

2. Biochemistry Division

7. Ichijima Y, Yoshioka K, Yoshioka Y, Shinohe K, Fujimori H, Unno J, Takagi M, Goto H, Inagaki M, Mizutani S, Teraoka H. DNA lesions induced by replication stress trigger mitotic aberration and tetraploidy development. PLoS ONE, 5:e8821, 2010

8. Ogino H, Nakayama R, Sakamoto H, Yoshida T, Sugimura T, Masutani M. Analysis of poly(ADP-ribose) polymerase-1 (PARP1) gene alteration in human germ cell tumor cell lines. Cancer Genet Cytogenet, 197:8-15, 2010

3. Chemotherapy Division

9. Kobayashi E, Masuda M, Nakayama R, Ichikawa H, Satow R, Shitashige M, Honda K, Yamaguchi U, Shoji A, Tochigi N, Morioka H, Toyama Y, Hirohashi S, Kawai A, Yamada T. Reduced argininosuccinate synthetase is a predictive biomarker for the development of pulmonary metastasis in patients with osteosarcoma. Mol Cancer Ther, 9:535-544, 2010

10. Matsubara J, Ono M, Honda K, Negishi A, Ueno H, Okusaka T, Furuse J, Furuta K, Sugiyama E, Saito Y, Kaniwa N, Sawada J, Shoji A, Sakuma T, Chiba T, Saijo N, Hirohashi S, Yamada T. Survival prediction for pancreatic cancer patients receiving gemcitabine treatment. Mol Cell Proteomics, 9:695-704, 2010

11. Sakane A, Honda K, Sasaki T. Rab13 regulates neurite outgrowth in PC12 cells through its effector protein, JRAB/MICAL-L2. Mol Cell Biol, 30:1077-1087, 2010

12. Satow R, Shitashige M, Kanai Y, Takeshita F, Ojima H, Jigami T, Honda K, Kosuge T, Ochiya T, Hirohashi S, Yamada T. Combined functional genome survey of therapeutic targets for hepatocellular carcinoma. Clin Cancer Res, 16:2518-2528, 2010

13. Shitashige M, Satow R, Jigami T, Aoki K, Honda K, Shibata T, Ono M, Hirohashi S, Yamada T. Traf2- and Nck-interacting kinase is essential for Wnt signaling and colorectal cancer growth. Cancer Res, 70:5024-5033, 2010

4. Biology Division

14. Kodama M, Otsubo C, Hirota T, Yokota J, Enari M, Taya Y. Requirement of ATM for rapid p53 phosphorylation at Ser46 without Ser/Thr-Gln sequences. Mol Cell Biol, 30:1620-1633, 2010

15. Kohno T, Kunitoh H, Shimada Y, Shiraishi K, Ishii Y, Goto K, Ohe Y, Nishiwaki Y, Kuchiba A, Yamamoto S, Hirose H, Oka A, Yanagitani N, Saito R, Inoko H, Yokota J. Individuals susceptible to lung adenocarcinoma defined by combined HLA-DQA1 and TERT genotypes. Carcinogenesis, 31:834-841, 2010

16. Kohno T, Otsuka A, Girard L, Sato M, Iwakawa R, Ogiwara H, Sanchez-Cespedes M, Minna JD, Yokota J. A catalog of genes homozygously deleted in human lung cancer and the candidacy of PTPRD as a tumor suppressor gene. Genes Chromosomes Cancer, 49:342-352, 2010

5. Cancer Medicine and Biophysics Division

6. Growth Factor Division

17. Miyazawa Y, Uekita T, Hiraoka N, Fujii S, Kosuge T, Kanai Y, Nojima Y, Sakai R. CUB domain-containing protein 1, a prognostic factor for human pancreatic cancers, promotes cell migration and extracellular matrix degradation. Cancer Res, 70:5136-5146, 2010

18. Tanaka M, Kamata R, Yanagihara K, Sakai R. Suppression of gastric cancer dissemination by ephrin-B1-derived peptide. Cancer Sci, 101:87-93, 2010

19. Yamaguchi H, Yoshida S, Muroi E, Kawamura M, Kouchi Z, Nakamura Y, Sakai R, Fukami K. Phosphatidylinositol 4,5-bisphosphate and PIP5-kinase Ia are required for invadopodia formation in human breast cancer cells. Cancer Sci, 101:1632-1638, 2010

7. Molecular Oncology Division

20. Aikawa Y, Katsumoto T, Zhang P, Shima H, Shino M, Terui K, Ito E, Ohno H, Stanley ER, Singh H, Tenen DG, Kitabayashi I. PU.1-mediated upregulation of CSF1R is crucial for leukemia stem cell potential induced by MOZ-TIF2. Nat Med, 16:580-585, 2010

21. Yokoyama A, Lin M, Naresh A, Kitabayashi I, Cleary ML. A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription. Cancer Cell, 17:198-212, 2010

8. Virology Division

22. Yoshida K, Sugimoro N, Iwahori S, Yugawa T, Narisawa-Saito M, Kiyono T, Fujita M. CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells. J Cell Sci, 123:225-235, 2010

23. Yugawa T, Narisawa-Saito M, Yoshimatsu Y, Haga K, Ohno S, Egawa N, Fujita M, Kiyono T. DNp63a repression of the Notch1 gene supports the proliferative capacity of normal human keratinocytes and cervical cancer cells. Cancer Res, 70:4034-4044, 2010

9. Genetics Division

10. Carcinogenesis Division

24. Kuzumaki N, Ikegami D, Imai S, Narita M, Tamura R, Yajima M, Suzuki A, Miyashita K, Niikura K, Takeshima H, Ando T, Ushijima T, Suzuki T, Narita M. Enhanced IL-1b: production in response to the activation of hippocampal glial cells impairs neurogenesis in aged mice. Synapse, 64:721-728, 2010

25. Kuzumaki N, Ikegami D, Tamura R, Hareyama N, Imai S, Narita M, Torigoe K, Niikura K, Takeshima H, Ando T, Igarashi K, Kanno J, Ushijima T, Suzuki T, Narita M. Hippocampal epigenetic modification at the brain-derived neurotrophic factor gene induced by an enriched environment. Hippocampus, 2010

26. Kuzumaki N, Ikegami D, Tamura R, Sasaki T, Niikura K, Narita M, Miyashita K, Imai S, Takeshima H, Ando T, Igarashi K, Kanno J, Ushijima T, Suzuki T, Narita M. Hippocampal epigenetic modification at the doublecortin gene is involved in the impairment of neurogenesis with aging. Synapse, 64:611-616, 2010

27. Nakajima T, Enomoto S, Yamashita S, Ando T, Nakanishi Y, Nakazawa K, Oda I, Gotoda T, Ushijima T. Persistence of a component of DNA methylation in gastric mucosae after Helicobacter pylori eradication. J Gastroenterol, 45:37-44, 2010

28. Niwa T, Tsukamoto T, Toyoda T, Mori A, Tanaka H, Maekita T, Ichinose M, Tatematsu M, Ushijima T. Inflammatory processes triggered by Helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells. Cancer Res, 70:1430-1440, 2010

29. Takeshima H, Ushijima T. Methylation destiny: Moira takes account of histones and RNA polymerase II. Epigenetics, 5:89-95, 2010

30. Ushijima T, Asada K. Aberrant DNA methylation in contrast with mutations. Cancer Sci, 101:300-305, 2010

11. Cancer Pathophysiology Division

31. Minami K, Sudo Y, Shiraishi S, Seo M, Uezono Y. Analysis of the effects of anesthetics and ethanol on m-opioid receptor. J Pharmacol Sci, 112:424-431, 2010

12. Section for Studies on Metastasis

32. Ishikawa T, Banas A, Hagiwara K, Iwaguro H, Ochiya T. Stem cells for hepatic regeneration: the role of adipose tissue derived mesenchymal stem cells. Curr Stem Cell Res Ther, 5:182-189, 2010

33. Kawamata M, Ochiya T. Establishment of embryonic stem cells from rat blastocysts. Methods Mol Biol, 597:169-177, 2010

34. Kosaka N, Iguchi H, Yoshioka Y, Takeshita F, Matsuki Y, Ochiya T. Secretory mechanisms and intercellular transfer of microRNAs in living cells. J Biol Chem, 285:17442-17452, 2010

35. Kosaka N, Izumi H, Sekine K, Ochiya T. microRNA as a new immune-regulatory agent in breast milk. Silence, 1:7, 2010

36. Ochiya T, Yamamoto Y, Banas A. Commitment of stem cells into functional hepatocytes. Differentiation, 79:65-73, 2010

37. Takeshita F, Patrawala L, Osaki M, Takahashi R, Yamamoto Y, Kosaka N, Kawamata M, Kelnar K, Bader AG, Brown D, Ochiya T. Systemic delivery of synthetic microRNA-16 inhibits the growth of metastatic prostate tumors via downregulation of multiple cell-cycle genes. Mol Ther, 18:181-187, 2010

38. Tanooka H, Tatsumi K, Tsuji H, Noda Y, Katsube T, Ishii H, Ootsuyama A, Takeshita F, Ochiya T. Mutant mouse p53 transgene elevates the chemical induction of tumors that respond to gene silencing with siRNA. Cancer Gene Ther, 17:1-10, 2010

13. Section for Studies on Host-Immune Response

14. Central RI Laboratory

15. Central Animal Laboratory

16. Cancer Genomics Project

39. Arai Y, Honda S, Haruta M, Kasai F, Fujiwara Y, Ohshima J, Sasaki F, Nakagawara A, Horie H, Yamaoka H, Hiyama E, Kaneko Y. Genome-wide analysis of allelic imbalances reveals 4q deletions as a poor prognostic factor and MDM4 amplification at 1q32.1 in hepatoblastoma. Genes Chromosomes Cancer, 49:596-609, 2010

40. Hasebe T, Tamura N, Iwasaki M, Okada N, Akashi-Tanaka S, Hojo T, Shimizu C, Adachi M, Fujiwara Y, Shibata T, Sasajima Y, Tsuda H, Kinoshita T. Grading system for lymph vessel tumor emboli: significant outcome predictor for patients with invasive ductal carcinoma of the breast who received neoadjuvant therapy. Mod Pathol, 23:581-592, 2010

41. Hasebe T, Tamura N, Okada N, Hojo T, Akashi-Tanaka S, Shimizu C, Tsuda H, Shibata T, Sasajima Y, Iwasaki M, Kinoshita T. p53 expression in tumor-stromal fibroblasts is closely associated with the nodal metastasis and outcome of patients with invasive ductal carcinoma who received neoadjuvant therapy. Hum Pathol, 41:262-270, 2010

42. Okada N, Hasebe T, Iwasaki M, Tamura N, Akashi-Tanaka S, Hojo T, Shibata T, Sasajima Y, Kanai Y, Kinoshita T. Metaplastic carcinoma of the breast. Hum Pathol, 41:960-970, 2010

17. Cancer Prevention Basic Research Project

43. Murakami Y, Imai N, Miura T, Sugimura T, Wakabayashi K, Totsuka Y, Hada N, Yokoyama Y, Suzuki H, Mitsunaga K. Chemical confirmation of the structure of a mutagenic aminophenylnorharman, 9-(4'-aminophenyl)-9H-pyrido[3,4-b]indole: an authentic synthesis of 9-(4'-nitrophenyl)-9H-pyrido[3,4-b]indole as its relay compound. Heterocycles, 80:455-462, 2010