Cumulated List of Papers Published in 2013

1. Division of Molecular Pathology

2. Division of Genetics

1. Fujita T, Yanagihara K, Takeshita F, Aoyagi K, Nishimura T, Takigahira M, Chiwaki F, Fukagawa T, Katai H, Ochiya T, Sakamoto H, Konno H, Yoshida T, Sasaki H. Intraperitoneal delivery of a small interfering RNA targeting NEDD1 prolongs the survival of scirrhous gastric cancer model mice. Cancer Sci, 104:214-222, 2013

3. Division of Familial Cancer Research

4. Division of Multistep Carcinogenesis

5. Division of Virology

6. Division of Cancer Development System

2. Ohata H, Miyazaki M, Otomo R, Matsushima-Hibiya Y, Otsubo C, Nagase T, Arakawa H, Yokota J, Nakagama H, Taya Y, Enari M. NuMA is required for the selective induction of p53 target genes. Mol Cell Biol, 33:2447-2457, 2013

7. Division of Metastasis and Invasion Signaling

8. Division of Molecular and Cellular Medicine

3. Fujita Y, Takeshita F, Kuwano K, Ochiya T. RNAi therapeutic platforms for lung diseases. Pharmaceuticals, 6:223-250, 2013

4. Fujiwara T, Kawai A, Yoshida A, Ozaki T, Ochiya T. Cancer stem cells of sarcoma. In: Fujiwara T, Kawai A, Yoshida A, Ozaki T, Ochiya T (eds), Role of cancer stem cells in cancer biology and therapy. USA, CRC Press, pp 23-78, 2013

5. Gailhouste L, Gomez-Santos L, Ochiya T. Potential applications of miRNAs as diagnostic and prognostic markers in liver cancer. Front Biosci, 18:199-223, 2013

6. Gailhouste L, Ochiya T. Cancer-related microRNAs and their role as tumor suppressors and oncogenes in hepatocellular carcinoma. Histol histopathol, 28:437-451, 2013

7. Gailhouste L, Ochiya T. MicroRNAs: new tools to tackle liver cancer progression. Cancer Diagnostics, pp 12-14, 2013

8. Hong J, He H, Bui P, Ryba-White B, Rumi MAK, Soares MJ, Dutta D, Paul S, Kawamata M, Ochiya T, Ying QL, Rajanahalli P, Weiss ML. A focused microarray for screening rat embryonic stem cell lines. Stem Cells Dev, 22:431-443, 2013

9. Izumi H, Kosaka N, Shimizu T, Sekine K, Ochiya T, Takase M. Purification of RNA from milk whey. Methods Mol Biol, 1024:191-201, 2013

10. Katsuda T, Kosaka N, Takeshita F, Ochiya T. The therapeutic potential of mesenchymal stem cell-derived extracellular vesicles. Proteomics, 13:1637-1653, 2013

11. Katsuda T, Teratani T, Chowdhury MM, Ochiya T, Sakai Y. Hypoxia efficiently induces differentiation of mouse embryonic stem cells into endodermal and hepatic progenitor cells. Biochemical Engineering Journal, 74:95-101, 2013

12. Katsuda T, Tsuchiya R, Kosaka N, Yoshioka Y, Takagaki K, Oki K, Takeshita F, Sakai Y, Kuroda M, Ochiya T. Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes. Sci Rep, 3:1197, 2013

13. Kosaka N, Iguchi H, Hagiwara K, Yoshioka Y, Takeshita F, Ochiya T. Neutral sphingomyelinase 2 (nSMase2)-dependent exosomal transfer of angiogenic microRNAs regulate cancer cell metastasis. J Biol Chem, 288:10849-10859, 2013

14. Kosaka N, Takeshita F, Yoshioka Y, Hagiwara K, Katsuda T, Ono M, Ochiya T. Exosomal tumor-suppressive microRNAs as novel cancer therapy: "exocure" is another choice for cancer treatment. Adv Drug Deliv Rev, 65:376-382, 2013

15. Kosaka N, Yoshioka Y, Hagiwara K, Tominaga N, Ochiya T. Functional analysis of exosomal microRNA in cell-cell communication research. Methods Mol Biol, 1024:1-10, 2013

16. Nakagawa SI, Hirata Y, Kameyama T, Tokunaga Y, Nishito Y, Hirabayashi K, Yano J, Ochiya T, Tateno C, Tanaka Y, Mizokami M, Tsukiyama-Kohara K, Inoue K, Yoshiba M, Takaoka A, Kohara M. Targeted induction of interferon-λ in humanized chimeric mouse liver abrogates hepatotropic virus infection. PLoS One, 8:e59611, 2013

17. Ochiya T, Lotvall J. Exosome as a novel shuttle for innovation. preface. Adv Drug Deliv Rev, 65:2013

18. Ohno S, Takanashi M, Sudo K, Ueda S, Ishikawa A, Matsuyama N, Fujita K, Mizutani T, Ohgi T, Ochiya T, Gotoh N, Kuroda M. Systemically injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cells. Mol Ther, 21:185-191, 2013

19. Suetsugu A, Honma K, Saji S, Moriwaki H, Ochiya T, Hoffman RM. Imaging exosome transfer from breast cancer cells to stroma at metastatic sites in orthotopic nude-mouse models. Adv Drug Deliv Rev, 65:383-390, 2013

20. Thirion M, Ochiya T. Extracellular microRNAs as potential biomarkers and therapeutic tools in cancer. In: López-Camarillo C, Marchat LA (eds), MicroRNAs in Cancer. USA, CRC Press, pp 308-332, 2013

21. Uchino K, Ochiya T, Takeshita F. RNAi therapeutics and applications of microRNAs in cancer treatment. Jpn J Clin Oncol, 43:596-607, 2013

22. Uchino K, Takeshita F, Takahashi RU, Kosaka N, Fujiwara K, Naruoka H, Sonoke S, Yano J, Sasaki H, Nozawa S, Yoshiike M, Kitajima K, Chikaraishi T, Ochiya T. Therapeutic Effects of MicroRNA-582-5p and -3p on the Inhibition of Bladder Cancer Progression. Mol Ther, 21:610-619, 2013

9. Division of Cancer Biology

10. Division of Cancer Differentiation

11. Division of Hematological Malignancy

12. Division of Pharmacogenomics

13. Division of Pharmacoproteomics

14. Division of Epigenomics

23. Asada K, Ando T, Niwa T, Nanjo S, Watanabe N, Okochi-Takada E, Yoshida T, Miyamoto K, Enomoto S, Ichinose M, Tsukamoto T, Ito S, Tatematsu M, Sugiyama T, Ushijima T. FHL1 on chromosome X is a single-hit gastrointestinal tumor-suppressor gene and contributes to the formation of an epigenetic field defect. Oncogene, 32:2140-2149, 2013

24. Asada K, Watanabe N, Nakamura Y, Ohira M, Westermann F, Schwab M, Nakagawara A, Ushijima T. Stronger prognostic power of the CpG island methylator phenotype than methylation of individual genes in neuroblastomas. Jpn J Clin Oncol, 43:641-645, 2013

25. Hirata A, Utikal J, Yamashita S, Aoki H, Watanabe A, Yamamoto T, Okano H, Bardeesy N, Kunisada T, Ushijima T, Hara A, Jaenisch R, Hochedlinger K, Yamada Y. Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium. Development, 140:66-75, 2013

26. Imai S, Ikegami D, Yamashita A, Shimizu T, Narita M, Niikura K, Furuya M, Kobayashi Y, Miyashita K, Okutsu D, Kato A, Nakamura A, Araki A, Omi K, Nakamura M, James Okano H, Okano H, Ando T, Takeshima H, Ushijima T, Kuzumaki N, Suzuki T, Narita M. Epigenetic transcriptional activation of monocyte chemotactic protein 3 contributes to long-lasting neuropathic pain. Brain, 136:828-843, 2013

27. Kim JG, Takeshima H, Niwa T, Rehnberg E, Shigematsu Y, Yoda Y, Yamashita S, Kushima R, Maekita T, Ichinose M, Katai H, Park WS, Hong YS, Park CH, Ushijima T. Comprehensive DNA methylation and extensive mutation analyses reveal an association between the CpG island methylator phenotype and oncogenic mutations in gastric cancers. Cancer Lett, 330:33-40, 2013

28. Niwa T, Toyoda T, Tsukamoto T, Mori A, Tatematsu M, Ushijima T. Prevention of Helicobacter pylori-induced gastric cancers in gerbils by a DNA demethylating agent. Cancer Prev Res (Phila), 6:263-270, 2013

15. Division of Genome Biology

29. Yoshida A, Kohno T, Tsuta K, Wakai S, Arai Y, Shimada Y, Asamura H, Furuta K, Shibata T, Tsuda H. ROS1-rearranged lung cancer: a clinicopathologic and molecular study of 15 surgical cases. Am J Surg Pathol, 37:554-562, 2013

16. Division of Cancer Genomics

30. Ichikawa M, Arai Y, Haruta M, Furukawa S, Ariga T, Kajii T, Kaneko Y. Meiosis error and subsequent genetic and epigenetic alterations invoke the malignant transformation of germ cell tumor. Genes Chromosomes Cancer, 52:274-286, 2013

17. Division of Cancer Pathophysiology

31. Minami K, Uezono Y. The recent progress in research on effects of anesthetics and analgesics on G protein-coupled receptors. J Anesth, 27:284-292, 2013

18. Division of Cancer Stem Cell

19. Division of Gene and Immune Medicine

32. Miura Y, Yamasaki S, Davydova J, Brown E, Aoki K, Vickers S, Yamamoto M. Infectivity-selective oncolytic adenovirus developed by high-throughput screening of adenovirus-formatted library. Mol Ther, 21:139-148, 2013

20. Division of Genome Stability Research

21. Division of Chemotherapy and Clinical Research

22. Central Animal Division

33. Imai T, Cho YM, Takahashi M, Kitahashi T, Takami S, Nishikawa A, Ogawa K. High susceptibility of heterozygous (+/fa) lean Zucker rats to 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis. Oncol Rep, 29:1914-1922, 2013

23. Central Radioisotope Division

24. Core Facility Division

25. Division of Refractory Cancer Research

26. Division of Cancer Prevention Research

34. Fujimoto K, Fujii G, Mutoh M, Yasunaga M, Tanaka H, Wada M. Suppression of intestinal polyp development in Apc^Min/+ mice through inhibition of P-glycoprotein using verapamil. Eur J Cancer Prev, 22:8-10, 2013

27. Division of Integrative Omics and Bioinformatics

35. Katoh M, Igarashi M, Fukuda H, Nakagama H, Katoh M. Cancer genetics and genomics of human FOX family genes. Cancer Lett, 328:198-206, 2013

28. Division of Brain Tumor Translational Research