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Home > Organization > Divisions and Independent Research Units > Group for Translational Research > Division of Cancer Pathophysiology > Research Projects > Development of novel opioid analgesics with less intolerance and fewer side effects

Development of novel opioid analgesics with less intolerance and fewer side effects

Opioids are used as strong analgesics in cancer patients; however, they show several types of side effects and tolerance as well. In our division, functions and properties of opioid receptors (μ, δ and κ) have been extensively studied. As a result, we have been able to develop novel opioid compounds with strong analgesic effects but less intolerance and fewer side effects. In collaboration with Laboratory of Medicinal Chemistry, School of Pharmacy, Kitasato University (Prof. Hideaki Fujii), we make respected opioid compounds in accordance with our basic research and investigate their functional properties with an established novel assay method in our laboratory.