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Home > Organization > Divisions and Independent Research Units > Group for Development of Molecular diagnostics and Individualized Therapy > Division of Epigenomics > Research Projects > Identification of DNA methylation abnormality in cancers and other disorders

Identification of DNA methylation abnormality in cancers and other disorders

It is known that various mutations and aberrant DNA methylation are accumulated in cancer cells. Recently, we revealed that aberrant DNA methylation of a specific gene can also be present in a large fraction of cells even in non-cancerous tissues, and that many genes are methylated in a single cancer cell.

In our laboratory, we revealed genes methylated in

In addition, we also revealed that specific genes are inactivated by aberrant DNA methylation in gastric glands with intestinal metaplasia , which is a disorder of cellular differentiation with a polyclonal origin.

We also revealed inducers of aberrant DNA methylation, namely chronic inflammation by Helicobacter pylori infection  in gastric mucosae and smoking  in esophageal mucosae.