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トップページ > 研究組織一覧 > 基盤的臨床開発研究コアセンター > オミックスコア > 臨床プロテオーム解析部門 > 論文業績

論文業績

2017年研究論文刊行成果

  • 雑誌論文
  1. Kagami Y, Ono M, Yoshida K. Plk1 phosphorylation of CAPH2 triggers chromosome condensation by condensin II at the early phase of mitosis. Sci Rep. 2017; in press
  2. Yoshimaru T, Ono M, Bando Y, Chen YA, Mizuguchi K, Shima H, Komatsu M, Imoto I, Izumi K, Honda J, Miyoshi Y, Sasa M, Katagiri T. A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells. Nat Commun. 2017; 8:15427. PMID: 28555617
  3. Masuda M, Yamada T. The emergence of TNIK as a therapeutic target for colorectal cancer. Expert Opin Ther Targets. 2017 Apr; 21(4):353-355. PMID: 28281900
  4. Yamada T, Masuda M. Emergence of TNIK inhibitors in cancer therapeutics. Cancer Sci. 2017 May; 108(5):818-823. PMID: 28208209
  5. Masuda M, Yamada T. Signaling pathway profiling using reverse-phase protein array and its clinical applications. Expert Rev Proteomics. 2017 Jul;14(7):607-615, PMID: 28621158
  6. 尾野雅哉. パラフィン包埋標本を用いたプロテオーム解析. 病理と臨床. 2017; 35(7):622-627.

2016年研究論文刊行成果

  • 雑誌論文
  1. Sawa M, Masuda M, Yamada T. Targeting the Wnt signaling pathway in colorectal cancer. Expert Opin Ther Targets. 2016 Apr;20(4):419-29. PMID: 26439805
  2. Masuda M, Uno Y, Ohbayashi N, Ohata H, Mimata A, Kukimoto-Niino M, Moriyama H, Kashimoto S, Inoue T, Goto N, Okamoto K, Shirouzu M, Sawa M, Yamada T. TNIK Inhibition Abrogates Colorectal Cancer Stemness. Nat Commun. 2016 Aug 26;7:12586. PMID: 2756264

2015年研究論文刊行成果

  • 雑誌論文
  1. Kamita M, Mori T, Sakai Y, Ito S, Gomi M, Miyamoto Y, Harada A, Niida S, Yamada T, Watanabe K, Ono M. Proteomic analysis of ligamentum flavum from patients with lumbar spinal stenosis. Proteomics. 2015; 15: 1622-1630. PMID: 25641790
  2. Atsumi Y, Minakawa Y, Ono M, Dobashi S, Shinohe K, Shinohara A, Takeda S, Takagi M, Takamatsu N, Nakagama H, Teraoka H, Yoshioka K. ATM and SIRT6/SNF2H Mediate Transient H2AX Stabilization When DSBs Form by Blocking HUWE1 to Allow Efficient gammaH2AX Foci Formation. Cell Rep. 2015; 13:2728-2740. PMID: 26711340
  3. Arai E, Gotoh M, Tian Y, Sakamoto H, Ono M, Matsuda A, Takahashi Y, Miyata S, Totsuka H, Chiku S, Komiyama M, Fujimoto H, Matsumoto K, Yamada T, Yoshida T, Kanai Y. Alterations of the spindle checkpoint pathway in clinicopathologically aggressive CpG island methylator phenotype clear cell renal cell carcinomas. Int J Cancer. 2015; 137:2589-2606. PMID: 26061684
  4. Miyanaga A, Masuda M, Tsuta K, Kawasaki K, Nakamura Y, Sakuma T, Asamura H, Gemma A, Yamada T. Hippo Pathway Gene Mutations in Malignant Mesothelioma Revealed by RNA and Targeted Exon Sequencing. J Thoracic Oncol. 10:844-51, 2015, PMID: 25902174
  5. Masuda M, Sawa M, Yamada T. Therapeutic targets in the Wnt signaling pathway: feasibility of targeting TNIK in colorectal cancer. Pharmacol Ther. 156:1-9, 2015, PMID: 26542362
  6. 尾野雅哉, 斎藤豊, 山田康秀: LCMS解析手法2DICALを用いた大腸癌関連マーカーの開発. GIResearch 2015 ; 23 : 31-37
  7. 増田万里、山田哲司: 創薬標的キナーゼとコンパニオン診断. 病理と臨床 2015 ; 33 : 191-197
  8. 山田哲司:「膵癌の新しい腫瘍マーカーによる早期診断」胆と膵 2015年2月号 36(2): 93 -98 2015年

2014年研究論文刊行成果

  • 雑誌論文
  1. Taira N, Yamaguchi T, Kimura J, Lu ZG, Fukuda S, Higashiyama S, Ono M, Yoshida K. Induction of amphiregulin by p53 promotes apoptosis via control of microRNA biogenesis in response to DNA damage. Proc Natl Acad Sci U S A. 2014; 111:717-722. PMID: 24379358
  2. Matsukawa S, Morita KI, Negishi A, Harada H, Nakajima Y, Shimamoto H, Tomioka H, Tanaka K, Ono M, Yamada T, Omura K. Galectin-7 as a potential predictive marker of chemo- and/or radio-therapy resistance in oral squamous cell carcinoma. Cancer Med. 2014; 3:349-36. PMID: 24515895
  3. Kagami Y, Nihira K, Wada S, Ono M, Honda M, Yoshida K. Mps1 phosphorylation of condensin II controls chromosome condensation at the onset of mitosis. J Cell Biol. 2014; 205:781-790. PMID: 24934155
  4. Kobayashi E, Satow R, Ono M, Masuda M, Honda K, Sakuma T, Kawai A, Morioka H, Toyama Y, Yamada T. MicroRNA expression and functional profiles of osteosarcoma. Oncology. 2014; 86(2):94-103. PMID: 24457375
  5. Yamada T. Reverse phase protein array: a tool for signaling pathway profiling in the era of genome resequencing. Dig Dis Sci. 2014 May;59(5):895-6. PMID: 24595655
  6. Masuda M, Chen WY, Miyanaga A, Nakamura Y, Kawasaki K, Sakuma T, Ono M, Chen CL, Honda K, Yamada T. Alternative mammalian target of rapamycin (mTOR) signal activation in sorafenib-resistant hepatocellular carcinoma cells revealed by array-based pathway profiling. Mol Cell Proteomics. 2014 Jun;13(6):1429-38. PMID: 24643969
  7. Masuda M, Yamada T. Signaling pathway profiling by reverse-phase protein array for personalized cancer medicine. BBA Proteins and Proteomics. 2014 Jun;1854(6):651-657. PMID: 25448010
  8. 尾野雅哉: プロテオーム解析システム2DICALを用いたバイオマーカー開発. 医学のあゆみ 2014; 251: 984-988

2013年研究論文刊行成果

  • 雑誌論文
  1. Yoneyama T, Ohtsuki S, Ono M, Ohmine K, Uchida Y, Yamada T, Tachikawa M, Terasaki T. Quantitative targeted absolute proteomics-based large-scale quantification of proline-hydroxylated alpha-fibrinogen in plasma for pancreatic cancer diagnosis. J Proteome Res. 2013; 12:753-762. PMID: 23298340
  2. Takahashi RU, Takeshita F, Honma K, Ono M, Kato K, Ochiya T. Ribophorin II regulates breast tumor initiation and metastasis through the functional suppression of GSK3beta. Sci Rep. 2013; 3:2474. PMID: 23959174
  3. Singh SK, Maeda K, Eid MM, Almofty SA, Ono M, Pham P, Goodman MF, Sakaguchi N. GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy. Nat Commun. 2013; 4:1830. PMID: 23652018
  4. Nakano T, Matsushima-Hibiya Y, Yamamoto M, Takahashi-Nakaguchi A, Fukuda H, Ono M, Takamura-Enya T, Kinashi H, Totsuka Y. ADP-ribosylation of guanosine by SCO5461 protein secreted from Streptomyces coelicolor. Toxicon. 2013; 63:55-63. PMID: 23212047
  5. Makuuchi Y, Honda K, Osaka Y, Kato K, Kojima T, Daiko H, Igaki H, Ito Y, Hoshino S, Tachibana S, Watanabe T, Furuta K, Sekine S, Umaki T, Watabe Y, Miura N, Ono M, Tsuchida A, Yamada T. Soluble interleukin-6 receptor is a serum biomarker for the response of esophageal carcinoma to neoadjuvant chemoradiotherapy. Cancer Sci. 2013; 104:1045-1051. PMID: 23648090
  6. Miyanaga A, Honda K, Tsuta K, Masuda M, Yamaguchi U, Fujii G, Miyamoto A, Shinagawa S, Miura N, Tsuda H, Sakuma T, Asamura H, Gemma A, Yamada T. Diagnostic and prognostic significance of the alternatively spliced ACTN4 variant in high-grade neuroendocrine pulmonary tumours. Ann Oncol. 2013 Jan;24(1):84-90. PMID: 22887464
  7. Honda K, Ono M, Shitashige M, Masuda M, Kamita M, Miura N, Yamada T. Proteomic approaches to the discovery of cancer biomarkers for early detection and personalized medicine.Jpn J Clin Oncol. 2013 Feb;43(2):103-9. PMID: 23248327

単行本

  • 増田万里、山田哲司: がんの個別化医療におけるチロシンキナーゼ阻害薬とコンパニオンバイオマーカー. 株式会社メディカル ドゥ:遺伝子MOOKオミックスで加速するがんバイオマーカー研究の最新動向;2015:257-261