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国立がん研究センター 中央病院

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Department of Dentistry

Takao Ueno, Wakako Yatsuoka, Takeo Kanayama, Kyoko Miyamoto, Erina Koyanagi, Mashio Shimano Chie Asano, Yuko Terade, Minami Ono, Mayumi Kogane


 Oral complications are common in patients receiving chemotherapy or undergoing radiation therapy of the head and neck.

 Oral complications during cancer treatment are directly linked to ingestion problems, and may even serve as a source of various infections such as aspiration pneumonia, thereby exacerbating systemic conditions, and sometimes preventing the completion of cancer treatment with negative effects on treatment prognoses. The oral health status of patients with cancer is associated with the incidence rate and the degree of severity of oral complications. Effective oral hygiene management before initiating cancer treatment will contribute to the reduction of oral complications such as mouth sores, oral mucositis, or dental infections, and provide important support to facilitate smooth cancer treatment.

The Team and What We Do

 To prevent or reduce oral complications, we check complication during cancer treatment oral conditions of the patients, identify the patients at risk and start preventive measures before cancer therapy begins.

 Our routine activities for cancer patients are below:

1) Management of oral complications of high-dose chemotherapy and/or stem cell transplant before treatment begins

2) Prevention and treatment of oral complications during chemotherapy and/or radiation therapy

3) Perioperative dental management for the prevention of postoperative pneumonia with oral, pharynx and esophageal surgery

4) Making prostheses for restoration of postoperative facial defects

5) Prevention and treatment of medicationassociated osteonecrosis of the jaw (MRONJ)

6) Cooperation business of a medical department and dentistry for the solution to dental problems of cancer patient.

 Total number of patients: 13,618

 Total number of new patients: 2,590


 Lecture and practice training concerning oral health care were regularly held for nurses and residents.

Future prospects

  • Making at new system that strengthen collaboration with nurse ~ An emphasis on preventive dental intervention, carried out screening of oral cavity problems.
  • Contribute to medicine- and dentistry-related collaboration in cancer care hospitals in the region.

List of papers published in 2018


1. Ueno T, Zenda S, Konishi T, Yurikusa T, Shibasaki Y, Nagamoto H, Fujii M. The post hoc analysis comparing the severity grades of chemoradiotherapy-induced oral mucositis scored between the central and local assessors in a multicenter, randomized controlled trial of rebamipide for head and neck cancer. Int J Clin Oncol, 24:241-247, 2019

2. Tanaka Y, Ueno T, Yoshida N, Akutsu Y, Takeuchi H, Baba H, Matsubara H, Kitagawa Y, Yoshida K. The effect of an elemental diet on oral mucositis of esophageal cancer patients treated with DCF chemotherapy: a multi-center prospective feasibility study (EPOC study). Esophagus, 15時23分9-248, 2018

3. Murakami N, Ueno T, Yatsuoka W, Okamoto H, Tselis N, Masui K, Yoshida K, Takahashi K, Inaba K, Okuma K, Igaki H, Nakayama Y, Itami J. Dose coverage comparison between "interstitial catheter-only" and "hybrid intracavitary-interstitial brachytherapy" for early stage squamous cell carcinoma of the buccal mucosa. J Contemp Brachytherapy, 10時48分6-491, 2018