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国立がん研究センター 中央病院

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Department of Hematopoietic Stem Cell Transplantation

Takahiro Fukuda, Takuya Yamashita, Sung-Won Kim, Saiko Kurosawa, Shigeo Fuji, Yoshihiro Inamoto, Takashi Tanaka, Akio Ohnishi


At the National Cancer Center Hospital, the Department of Hematopoietic Stem Cell Transplantation (HSCT) specializes in patients who undergo allogeneic or autologous HSCT. Twenty-six beds in ward 12B and an additional three beds on ward 11A, which are filtered by a central highefficiency particulate air filtration system, are solely dedicated to our Transplant Unit.

Routine activities

Six staff physicians (Drs. Yamashita, Kim, Kurosawa, Fuji, Inamoto, and Fukuda) and two chief residents (Drs. Tanaka and Ohnishi) participate in the transplant program. Children who have undergone HSCT are managed in collaboration with Dr. Ogawa, the chief of the Department of Pediatric Oncology, and the transplant team. In 2015, a total of 106 transplantations were performed at the 12B and 12A transplant units. The numbers of each type of HCST between 2011 and 2015 are shown in Table 1, and the numbers of patients according to disease type are shown in Table 2.

At the weekly conference on Monday afternoons, in collaboration with doctors of the Dopartment of Hematology, about 30 hospitalized HSCT patients and those who have been referred for HSCT, are reviewed for clinical management and a decision regarding their eligibility for HSCT. The transplant unit is staffed by 24 nurses trained in oncology and specialized supportive care for HSCT patients. The nursing unit has been assuming leadership in an effort to facilitate improved care for skin and gut graft-versus-host disease (GVHD), and establishment of a Long-term Follow-up Unit (LTFU) for the education of patients and their family members. In 2015, 370 patients visited our LTFU clinic. At the weekly 12B ward meeting on Friday afternoons, all HSCT patients are reviewed in detail by all transplant team members including doctors, nurses, pharmacists, the nutritional support team, clinical research coordinators, and the transplant coordinator.

Research activities and Clinical trials

Our transplant team has been focusing on the development of comprehensive cellular immunotherapy, including reduced-intensity stem cell transplants for elderly patients. A clinical trial of post-transplant consolidation with the WT1 vaccine has been completed. We have started nationwide studies focusing on HSCT for patients with adult T-cell leukemia. Our study suggested that the use of mogamulizumab, anti-CCR4 antibody, before allogeneic HSCT significantly worsened the clinical outcome, mainly due to an increased risk of acute GVHD. We have also published a large nationwide survey of quality of life (QOL) in 576 patients with acute leukemia. In 2015, we published 27 articles in peer-reviewed international journals.

Table 1. Number of each type of HSCT


Table 2. Number of patients who underwent HSCT in 2015

List of papers published in 2015


  1. Ueda R, Fuji S, Mori S, Hiramoto N, Hashimoto H, Tanaka T, Tada K, Kobayashi Y, Morikawa N, Shinohara A, Okinaka K, Maeshima AM, Kurosawa S, Kim SW, Yamashita T, Fukuda T. Characteristics and outcomes of patients diagnosed with norovirus gastroenteritis after allogeneic hematopoietic stem cell transplantation based on immunochromatography. Int J Hematol, 102:121-128, 2015
  2. Kurosawa S, Yamaguchi T, Mori T, Kanamori H, Onishi Y, Emi N, Fujisawa S, Kohno A, Nakaseko C, Saito B, Kondo T, Hino M, Nawa Y, Kato S, Hashimoto A, Fukuda T. Patient-reported quality of life after allogeneic hematopoietic cell transplantation or chemotherapy for acute leukemia. Bone Marrow Transplant, 50:1241-1249, 2015
  3. Fuji S, Yakushijin K, Kim SW, Yoshimura K, Kurosawa S, Fukuda T. Dynamic change of glycemic status during the early phase after allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant, 50:1473-1475, 2015
  4. Fuji S, Mori T, Khattry N, Cheng J, Do YR, Yakushijin K, Kohashi S, Fukuda T, Kim SW. Severe weight loss in 3 months after allogeneic hematopoietic SCT was associated with an increased risk of subsequent non-relapse mortality. Bone Marrow Transplant, 50:100-105, 2015
  5. Fuji S, Kanda J, Kato S, Ikegame K, Morishima S, Miyamoto T, Hidaka M, Kubo K, Miyamura K, Tsudo M, Kobayashi H, Maesako Y, Eto T, Adachi S, Ichinohe T, Atsuta Y, Kanda Y, HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation. A single high-resolution HLA mismatch has a similar adverse impact on the outcome of related hematopoietic stem cell transplantation as a single low-resolution HLA mismatch. Am J Hematol, 90:618-623, 2015
  6. Fuji S. Haploidentical Related Peripheral Blood Stem Cell Transplantation as a Salvage Transplantation in Patients with Graft Failure. Intern Med, 54:2709-2710, 2015
  7. Fuji S, Einsele H, Savani BN, Kapp M. Systematic Nutritional Support in Allogeneic Hematopoietic Stem Cell Transplant Recipients. Biol Blood Marrow Transplant, 21:1707-1713, 2015
  8. Takano K, Fuji S, Uchida N, Ogawa H, Ohashi K, Eto T, Sakamaki H, Morishima Y, Kato K, Suzuki R, Fukuda T. Pre-transplant diabetes mellitus is a risk factor for non-relapse mortality, especially infection-related mortality, after allogeneic hematopoietic SCT. Bone Marrow Transplant, 50:553-558, 2015
  9. Inamoto Y, Flowers ME, Wang T, Urbano-Ispizua A, Hemmer MT, Cutler CS, Couriel DR, Alousi AM, Antin JH, Gale RP, Gupta V, Hamilton BK, Kharfan-Dabaja MA, Marks DI, Ringdén OT, Socié G, Solh MM, Akpek G, Cairo MS, Chao NJ, Hayashi RJ, Nishihori T, Reshef R, Saad A, Shah A, Teshima T, Tallman MS, Wirk B, Spellman SR, Arora M, Martin PJ. Tacrolimus versus Cyclosporine after Hematopoietic Cell Transplantation for Acquired Aplastic Anemia. Biol Blood Marrow Transplant, 21:1776-1782, 2015
  10. Inamoto Y, Sun YC, Flowers ME, Carpenter PA, Martin PJ, Li P, Wang R, Chai X, Storer BE, Shen TT, Lee SJ. Bandage Soft Contact Lenses for Ocular Graft-versus-Host Disease. Biol Blood Marrow Transplant, 21:2002-2007, 2015
  11. Inamoto Y, Shah NN, Savani BN, Shaw BE, Abraham AA, Ahmed IA, Akpek G, Atsuta Y, Baker KS, Basak GW, Bitan M, DeFilipp Z, Gregory TK, Greinix HT, Hamadani M, Hamilton BK, Hayashi RJ, Jacobsohn DA, Kamble RT, Kasow KA, Khera N, Lazarus HM, Malone AK, Lupo-Stanghellini MT, Margossian SP, Muffly LS, Norkin M, Ramanathan M, Salooja N, Schoemans H, Wingard JR, Wirk B, Wood WA, Yong A, Duncan CN, Flowers ME, Majhail NS. Secondary solid cancer screening following hematopoietic cell transplantation. Bone Marrow Transplant, 50:1013-1023, 2015
  12. Ogata M, Fukuda T, Teshima T. Human herpesvirus-6 encephalitis after allogeneic hematopoietic cell transplantation: what we do and do not know. Bone Marrow Transplant, 50:1030- 1036, 2015
  13. Takenaka K, Nishida T, Asano-Mori Y, Oshima K, Ohashi K, Mori T, Kanamori H, Miyamura K, Kato C, Kobayashi N, Uchida N, Nakamae H, Ichinohe T, Morishima Y, Suzuki R, Yamaguchi T, Fukuda T. Cytomegalovirus Reactivation after Allogeneic Hematopoietic Stem Cell Transplantation is Associated with a Reduced Risk of Relapse in Patients with Acute Myeloid Leukemia Who Survived to Day 100 after Transplantation: The Japan Society for Hematopoietic Cell Transplantation Transplantation- related Complication Working Group. Biol Blood Marrow Transplant, 21:2008-2016, 2015
  14. Mohty M, Malard F, Abecassis M, Aerts E, Alaskar AS, Aljurf M, Arat M, Bader P, Baron F, Bazarbachi A, Blaise D, Ciceri F, Corbacioglu S, Dalle JH, Duarte RF, Fukuda T, Huynh A, Masszi T, Michallet M, Nagler A, NiChonghaile M, Pagluica T, Peters C, Petersen FB, Richardson PG, Ruutu T, Savani BN, Wallhult E, Yakoub-Agha I, Carreras E. Sinusoidal obstruction syndrome/veno-occlusive disease: current situation and perspectives-a position statement from the European Society for Blood and Marrow Transplantation (EBMT). Bone Marrow Transplant, 50:781-789, 2015
  15. Nakasone H, Fukuda T, Kanda J, Mori T, Yano S, Kobayashi T, Miyamura K, Eto T, Kanamori H, Iwato K, Uchida N, Mori S, Nagamura-Inoue T, Ichinohe T, Atsuta Y, Teshima T, Murata M, GVHD working group of the Japan Society of Hematopoietic Cell Transplantation. Impact of conditioning intensity and TBI on acute GVHD after hematopoietic cell transplantation. Bone Marrow Transplant, 50:559-565, 2015
  16. Nakane T, Fukuda T, Kanda J, Taniguchi S, Eto T, Ohashi K, Nakamae H, Kurokawa M, Mori T, Morishima Y, Nagamura-Inoue T, Sakamaki H, Atsuta Y, Murata M. Age influences postgraft- versus-host disease non-relapse mortality in adults with acute graft-versus-host disease of varying severity following allogeneic hematopoietic cell transplant. Leuk Lymphoma, 56:2392-2397, 2015
  17. Arai Y, Aoki K, Takeda J, Kondo T, Eto T, Ota S, Hashimoto H, Fukuda T, Ozawa Y, Kanda Y, Kato C, Kurokawa M, Iwato K, Onizuka M, Ichinohe T, Atsuta Y, Takami A, AML and MDS Working Group of Japan Society for Hematopoietic Cell Transplantation. Clinical significance of high-dose cytarabine added to cyclophosphamide/total-body irradiation in bone marrow or peripheral blood stem cell transplantation for myeloid malignancy. J Hematol Oncol, 8:102, 2015
  18. Nomoto H, Takami A, Espinoza JL, Matsuo K, Mizuno S, Onizuka M, Kashiwase K, Morishima Y, Fukuda T, Kodera Y, Doki N, Miyamura K, Mori T, Nakao S, Ohtake S, Morishita E. A donor thrombomodulin gene variation predicts graft-versus-host disease development and mortality after bone marrow transplantation. Int J Hematol, 102:460-470, 2015
  19. Aoki T, Suzuki R, Kuwatsuka Y, Kako S, Fujimoto K, Taguchi J, Kondo T, Ohata K, Ito T, Kamoda Y, Fukuda T, Ichinohe T, Takeuchi K, Izutsu K, Suzumiya J. Long-term survival following autologous and allogeneic stem cell transplantation for blastic plasmacytoid dendritic cell neoplasm. Blood, 125:3559-3562, 2015
  20. Tanaka M, Miyamura K, Terakura S, Imai K, Uchida N, Ago H, Sakura T, Eto T, Ohashi K, Fukuda T, Taniguchi S, Mori S, Nagamura-Inoue T, Atsuta Y, Okamoto S. Comparison of cord blood transplantation with unrelated bone marrow transplantation in patients older than fifty years. Biol Blood Marrow Transplant, 21:517-525, 2015
  21. Kanda J, Ichinohe T, Fuji S, Maeda Y, Ohashi K, Fukuda T, Miyamura K, Iwato K, Eto T, Nakamae H, Kobayashi N, Mori T, Mori S, Morishima Y, Atsuta Y, Kanda Y, HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation. Impact of HLA mismatch direction on the outcome of unrelated bone marrow transplantation: a retrospective analysis from the Japan Society for Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant, 21:305-311, 2015
  22. Kako S, Izutsu K, Kato K, Kim SW, Mori T, Fukuda T, Kobayashi N, Taji H, Hashimoto H, Kondo T, Sakamaki H, Morishima Y, Kato K, Suzuki R, Suzumiya J, Adult Lymphoma Working Group of the Japanese Society for Hematopoietic Cell Transplantation. The role of hematopoietic stem cell transplantation for relapsed and refractory Hodgkin lymphoma. Am J Hematol, 90:132-138, 2015
  23. Aoki K, Ishikawa T, Ishiyama K, Aoki J, Itonaga H, Fukuda T, Kakihana K, Uchida N, Ueda Y, Eto T, Mori T, Kondo T, Iwato K, Morishima Y, Tanaka J, Atsuta Y, Miyazaki Y, Adult MyelodysplasticSyndromes Working Group of the Japan Society for Hematopoietic Cell Transplantation (JSHCT). Allogeneic haematopoietic cell transplantation with reduced-intensity conditioning for elderly patients with advanced myelodysplastic syndromes: a nationwide study. Br J Haematol, 168:463-466, 2015
  24. Ishida H, Kato M, Kudo K, Taga T, Tomizawa D, Miyamura T, Goto H, Inagaki J, Koh K, Terui K, Ogawa A, Kawano Y, Inoue M, Sawada A, Kato K, Atsuta Y, Yamashita T, Adachi S. Comparison of Outcomes for Pediatric Patients With Acute Myeloid Leukemia in Remission and Undergoing Allogeneic Hematopoietic Cell Transplantation With Myeloablative Conditioning Regimens Based on Either Intravenous Busulfan or Total Body Irradiation: A Report From the Japanese Society for Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant, 21:2141-2147, 2015
  25. Yano S, Mori S, Saito T, Yokoyama H, Machishima T, Shimada T, Yahagi Y, Sugiyama K, Ogasawara Y, Takahara S, Kasama K, Katsube A, Kamiyama Y, Suzuki K, Inui Y, Usui N, Aiba K, Yamashita T. Pharmacokinetics for once-daily modified release formulation of tacrolimus hydrate in unrelated hematopoietic stem cell transplantation. Ann Hematol, 94:491-496, 2015
  26. Hashimoto H, Kitano S, Ueda R, Ito A, Tada K, Fuji S, Kim SW, Yamashita T, Tomura D, Nukaya I, Mineno J, Fukuda T, Mori S, Takaue Y, Heike Y. Infusion of donor lymphocytes expressing the herpes simplex virus thymidine kinase suicide gene for recurrent hematologic malignancies after allogeneic hematopoietic stem cell transplantation. Int J Hematol, 102:101-110, 2015 (Erratum in : Int J Hematol. 102:506, 2015)
  27. Hashimoto H, Kitano S, Yamagata S, Miyagi Maeshima A, Ueda R, Ito A, Tada K, Fuji S, Yamashita T, Tomura D, Nukaya I, Mineno J, Fukuda T, Mori S, Takaue Y, Heike Y. Donor lymphocytes expressing the herpes simplex virus thymidine kinase suicide gene: detailed immunological function following add-back after haplo-identical transplantation. Cytotherapy, 17:1820-1830, 2015