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Home > Organization > Fundamental Innovative Oncology Core > Biology and Disease Model Core > Department of Innovative Seeds Evaluation > Research Papers > 原著論文

原著論文

2017年

  1. Qiao Z, Tajim T, Kito F, Arai Y, Kawai A, Kondo T. Metastasis-associated gene signature in primary myxoid liposarcoma identified through a gene expression study. J Electrophoresis. In press.
  2. Qiao Z, Kito F, Takai Y, Oyama R, Kondo T. Secretomics identifies follistatin as a predictive biomarker for response to treatment with tyrosine kinase inhibitors in synovial sarcoma. J Electrophoresis. In press
  3. Sakumoto M, Takahashi M, Oyama R, Takai Y, Kito F, Shiozawa K, Qiao Z, Yoshida A, Endo M, Kawai A, Kondo T. Establishment and proteomic characterization of NCC-LMS1-C1, a novel cell line of primary leiomyosarcoma in the bone. Jap J Clin Oncol. In press
  4. Kikuta K, Kubota D, Yoshida A, Qiao Z, Morioka H, Nakamura M, Matsumoto M, Chuman H, Kawai A, Kondo T. Discoidin, CUB and LCCL domain-containing protein 2 (DCBLD2) is a novel biomarker of myxofibrosarcoma invasion identified by global protein expression profiling. Biochim Biophys Acta. 2017 Jun 29;1865(9):1160-1166.
    PubMed PMID: 28668639.
  5. Oyama R, Takahashi M, Yoshida A, Sakumoto M, Takai Y, Kito F, Shiozawa K, Qiao Z, Arai Y, Shibata T, Araki Y, Endo M, Kawai A, Kondo T. Generation of novel patient-derived CIC- DUX4 sarcoma xenografts and cell lines. Sci Rep. 2017 Jul 5;7(1):4712.
    PubMed PMID: 28680140.
  6. Nakasuji T, Ogonuki N, Chiba T, Kato T, Shiozawa K, Yamatoya K, Tanaka H, Kondo T, Miyado K, Miyasaka N, Kubota T, Ogura A, Asahara H. Complementary Critical Functions of Zfy1 and Zfy2 in Mouse Spermatogenesis and Reproduction. PLoS Genet. 2017 Jan 23;13(1):e1006578. doi: 10.1371/journal.pgen.1006578. eCollection 2017 Jan.
    PubMed PMID: 28114340; PubMed Central PMCID: PMC5287576.
  7. Asano N, Yoshida A, Mitani S, Kobayashi E, Shiotani B, Komiyama M, Fujimoto H, Chuman H, Morioka H, Matsumoto M, Nakamura M, Kubo T, Kato M, Kohno T, Kawai A, Kondo T, Ichikawa H. Frequent amplification of receptor tyrosine kinase genes in welldifferentiated/ dedifferentiated liposarcoma. Oncotarget. 2017 Feb 21;8(8):12941-12952. doi: 10.18632/oncotarget.14652.
    PubMed PMID: 28099935; PubMed Central PMCID: PMC5355068.

2016年

  1. Kubota D, Kosaka N, Fujiwara T, Yoshida A, Arai Y, Qiao Z, Takeshita F, Ochiya T, Kawai A, Kondo T. miR-125b and miR-100 Are Predictive Biomarkers of Response to Induction Chemotherapy in Osteosarcoma. Sarcoma. 2016;2016:1390571.
    PubMed PMID: 27990096; PubMed Central PMCID: PMC5136640
  2. Yamasaki H, Miyamoto M, Yamamoto Y, Kondo T, Watanabe T, Ohta T. Synovial sarcoma cell lines showed reduced DNA repair activity and sensitivity to a PARP inhibitor. Genes Cells. 2016 Aug;21(8):852-60. doi: 10.1111/gtc.12387.
    PubMed PMID: 27353471
  3. Qiao Z, Pan X, Parlayan C, Ojima H, Kondo T. Proteomic study of hepatocellular carcinoma using a novel modified aptamer-based array (SOMAscan™) platform. Biochim Biophys Acta. 2017 Apr;1865(4):434-443. doi:10.1016/j.bbapap.2016.09.011. Epub 2016 Sep 20. PubMed PMID: 27663888.
    PubMed PMID: 27663888
  4. Ezawa I, Sawai Y, Kawase T, Okabe A, Tsutsumi S, Ichikawa H, Kobayashi Y, Tashiro F, Namiki H, Kondo T, Semba K, Aburatani H, Taya Y, Nakagama H, Ohki R. Novel p53 target gene FUCA1 encodes a fucosidase and regulates growth and survival of cancer cells. Cancer Sci. 2016 Jun;107(6):734-45. doi:10.1111/cas.12933. Epub 2016 May 16.
    PubMed PMID: 26998741
  5. Morofuji N, Ojima H, Hiraoka N, Okusaka T, Esaki M, Nara S, Shimada K, Kishi Y, Kondo T. Antibody-based proteomics to identify an apoptosis signature for early recurrence of hepatocellular carcinoma. Clin Proteomics. 2016 Oct 24;13:28. eCollection 2016.
    PubMed PMID: 27799868; PubMed Central PMCID: PMC5078925.
  6. Asano Y, Kawase T, Okabe A, Tsutsumi S, Ichikawa H, Tatebe S, Kitabayashi I, Tashiro F, Namiki H, Kondo T, Semba K, Aburatani H, Taya Y, Nakagama H, Ohki R. IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis. Sci Rep. 2016 Jan 12;6:19174. doi: 10.1038/srep19174.
    PubMed PMID: 26754925; PubMed Central PMCID: PMC4709660
  7. Takai Y, Matsuo A, Qiao Z, Kondo T. Antitumor activities of BIBF 1120, BI860585, and BI 836845 un preclinical models of sarcoma. Integr Mol Med. 2016 3(4): 755-760, 2016
    doi: 10.15761/IMM.1000239

2015年

  1. Tajima T, Kito F, Ohta T, Kawai A, Kondo T. Interactome approach to SBP-1 binding protein in lung adenocarcinoma. J Electrophoresis, 59:1-6, 2015
    https://www.jstage.jst.go.jp/article/jelectroph/59/1/59_1/_pdf(PDF:879KB)(外部リンク)
  2. Ichikawa H, Yoshida A, Kanda T, Kosugi S, Ishikawa T, Hanyu T, Taguchi T, Sakumoto M, Katai H, Kawai A, Wakai T, Kondo T. Prognostic significance of promyelocytic leukemia expression in gastrointestinal stromal tumor; integrated proteomic and transcriptomic analysis. Cancer Sci. 2015 Jan;106(1):115-24. doi: 10.1111/cas.12565. Epub 2014 Dec 4. [PubMed](外部リンク)
  3. 谷勇樹、ジュネイド・パラヤン、高井庸子、川井章、鵜沼豊、木下英樹、近藤格.全自動二次元電気泳動装置(Auto2D)における狭小幅イモビラインpH勾配ゲルの評価.電気泳動 2015;59:9 doi:10.2198/electroph.59.9[日本電気泳動学会](外部リンク)

2014年

  1. Taoka M, Morofuji N, Yamauchi Y, Ojima H, Kubota D, Terukina G, Nobe Y, Nakayama H, Takahashi N, Kosuge T, Isobe T, Kondo T. Global PROTOMAP profiling to search for biomarkers of early-recurrent hepatocellular carcinoma. J Proteome Res. 2014 Jun 26. [Epub ahead of print] PMID: 24967658.[PubMed](外部リンク)
  2. Hosoya N, Sakumoto M, TomitaY, Kondo T. Approach to spot overlapping problem in 2D-PAGE revealed clinical and functional significance of RKIP and MnSOD in renal cell carcinoma. EuPA Open Proteomics 2014 4: 129-139. EuPaA Open Protreomics(外部リンク)
  3. MukaiharaK, Kubota D, Yoshida A, Kawai A, Kondo T. Proteomic profile of epitheliod sarcoma. J Proteomics Bioinform 2014, 7:7 158-165. Proteomics & Bioinformatics(PDF:3670KB)
  4. Ito M, Hagiyama M, Mimae T, Inoue T, Kato T, Yoneshige A, Nakanishi J, Kondo T, Okada M, Ito A. α-Parvin, a pseudopodial constituent, promotes cell motility and is associated with lymph node metastasis of lobular breast carcinoma. Breast Cancer Res Treat. 2014 Feb;144(1):59-69. doi: 10.1007/s10549-014-2859-0. Epub 2014 Feb 5. [PubMed](外部リンク)
  5. Fujiwara T, Katsuda T, Hagiwara K, Kosaka N, Yoshioka Y, Takahashi RU, Takeshita F, Kubota D, Kondo T, Ichikawa H, Yoshida A, Kobayashi E, Kawai A, Ozaki T, Ochiya T. Clinical relevance and therapeutic significance of microRNA-133a expression profiles and functions in malignant osteosarcoma-initiating cells. Stem Cells. 2014 Apr;32(4):959-73. doi: 10.1002/stem.1618. [PubMed](外部リンク)
  6. Kubota D, Yoshida A, Kawai A, Kondo T. Proteomics identified overexpression of SET oncogene product and possible therapeutic utility of protein phosphatase 2A in alveolar soft part sarcoma. J Proteome Res. 2014 May 2;13(5):2250-61. doi: 10.1021/pr400929h. Epub 2014 Mar 31. [PubMed](外部リンク)
  7. Mimae T, Ito A, Hagiyama M, Nakanishi J, Hosokawa Y, Okada M, Murakami Y, Kondo T. A novel approach to pseudopodia proteomics: excimer laser etching, two-dimensional difference gel electrophoresis, and confocal imaging. Protoc exch. 2014 Mar 4;2014. pii: 2014.007. [PubMed](外部リンク)
  8. Kubota D, Yoshida A, Kikuta K, Saito T, Suehara Y, Gotoh M, Kawai A, Kondo T. Proteomic approach to gastrointestinal stromal tumor identified prognostic biomarkers. J Proteomics Bioinform 2014, 7:1 10-16. Proteomics & Bioinformatics(PDF:972KB)
  9. Ichikawa H, Kanda T, Kosugi S, Kawachi Y, Wakai T, Kondo T. Proteomic and meta-transcriptomic study on lymph node metastasis in gastric cancer. EuPA Open proteomics. 2014; 3:183-194. EuPaA Open Protreomics(外部リンク)

2013年

  1. Hosoya N, Sakumoto M, Nakamura Y, Narisawa T, Bilim V, Motoyama T, Tomita Y, Kondo T. Proteomics identified nuclear N-myc downstream-regulated gene 1 as a prognostic tissue biomarker candidate in renal cell carcinoma. Biochim Biophys Acta. 2013;1834(12):2630-9. Epub 2013/ 09/ 04. PMID: 23999030.[PubMed](外部リンク)
  2. Kubota D, Yoshida A, Tsuda H, Suehara Y, Okubo T, Saito T, Orita H, Sato K, Taguchi T, Yao T, Kaneko K, Katai H, Kawai A, Kondo T. Gene expression network analysis of ETV1 reveals KCTD10 as a novel prognostic biomarker in gastrointestinal stromal tumor. PloS One. 2013;8(8):e73896. Epub 2013/ 08/ 27. PMID: 23977394.[PubMed](外部リンク)
  3. Kubota D, Mukaihara K, Yoshida A, Tsuda H, Kawai A, Kondo T. Proteomics study of open biopsy samples identifies peroxiredoxin 2 as a predictive biomarker of response to induction chemotherapy in osteosarcoma. J Proteomics. 2013;91C:393-404. Epub 2013/ 08/ 06. PMID: 23911960.[PubMed](外部リンク)
  4. Ichikawa H, Kanda T, Kosugi S. I, Kawachi Y, Sasaki H, Wakai T, Kondo T. Laser microdissection and two-dimensional difference gel electrophoresis reveal the role of a novel macrophage-capping protein in lymph node metastasis in gastric cancer.J Proteome Res. 2013;12(8):3780-91. Epub 2013/ 06/ 21. PMID: 23782053.[PubMed](外部リンク)
  5. Yonemori H, Kubota D, Taniguchi H, Tsuda H, Fujita S, Murakami Y, Kondo T. Laser microdissection and two-dimensional difference gel electrophoresis with alkaline isoelectric point immobiline gel reveals proteomic intra-tumor heterogeneity in colorectal cancer. EuPA Open Proteomics. 2013;1:17-29.ScienceDirect(外部リンク)
  6. Arai K, Sakamoto R, Kubota D, Kondo T. Proteomic approach toward molecular backgrounds of drug resistance of osteosarcoma cells in spheroid culture system. Proteomics. 2013;13(15):2351-60. Epub 2013/ 05/ 29. PMID: 23712969.[PubMed](外部リンク)
  7. Kubota D, Mukaihara K, Yoshida A, Suehara Y, Saito T, Okubo T, Gotoh M, Orita H, Tsuda H, Kaneko K, Kawai A, Kondo T. The prognostic value of Pfetin: a validation study in gastrointestinal stromal tumors using a commercially available antibody. Jpn J Clin Oncol. 2013;43(6):669-75. Epub 2013/ 04/ 27. PMID: 23619989.[PubMed](外部リンク)
  8. Kimura K, Ojima H, Kubota D, Sakumoto M, Nakamura Y, Tomonaga T, Kosuge T, Kondo T. Proteomic identification of the macrophage-capping protein as a protein contributing to the malignant features of hepatocellular carcinoma. J Proteomics. 2013;78:362-73. Epub 2012/ 10/ 23. PMID: 23085225.[PubMed](外部リンク)
  9. Huang C, Wang Y, Liu S, Ding G, Liu W, Zhou J, Kuang M, Ji Y, Kondo T, Fan J. Quantitative proteomic analysis identified Paraoxonase 1 as a novel serum biomarker for microvascular invasion in hepatocellular carcinoma. J Proteome Res. 2013;12(4):1838-46. Epub 2013/ 02/ 28. PMID: 23442176.[PubMed](外部リンク)
  10. Haga A, Ogawara Y, Kubota D, Kitabayashi I, Murakami Y, Kondo T. Interactomic approach for evaluating nucleophosmin-binding proteins as biomarkers for Ewing's sarcoma. Electrophoresis. 2013;34(11):1670-8. Epub 2013/ 03/ 14. PMID: 23483572.[PubMed](外部リンク)
  11. Yamamoto T, Nakayama K, Hirano H, Tomonaga T, Ishihama Y, Yamada T, Kondo T, Kodera Y, Sato Y, Araki N, Mamitsuka H, Goshima N. Integrated view of the human chromosome X-centric proteome project. J Proteome Res. 2013;12(1):58-61. Epub 2012/ 12/ 25. PMID: 23259409.[PubMed](外部リンク)
  12. Sugihara Y, Taniguchi H, Kushima R, Tsuda H, Kubota D, Ichikawa H, Fujita S, Kondo T. Laser microdissection and two-dimensional difference gel electrophoresis reveal proteomic intra-tumor heterogeneity in colorectal cancer. J Proteomics. 2013;78:134-47. Epub 2012/ 11/ 28. PMID: 23178874.[PubMed](外部リンク)
  13. Hasegawa T, Asanuma H, Ogino J, Hirohashi Y, Shinomura Y, Iwaki H, Kikuchi H, Kondo T. Use of potassium channel tetramerization domain-containing 12 as a biomarker for diagnosis and prognosis of gastrointestinal stromal tumor. Hum Pathol.2013;44(7):1271-7. Epub 2013/ 01/ 08. PMID: 23290008.[PubMed](外部リンク)

2012年

  1. Uhlén M, Oksvold P, Älgenäs C, Hamsten C, Fagerberg L, Klevebring D, Lundberg E, Odeberg J, Pontén F, Kondo T, Sivertsson Å. Antibody-based protein profiling of the human chromosome 21. Mol Cell Proteomics. 2012;11(3):M111.013458. PMID: 22042635.[PubMed](外部リンク)
  2. Sugihara Y, Taniguchi H, Kushima R, Tsuda H, Kubota D, Ichikawa H, Sakamoto K, Nakamura Y, Tomonaga T, Fujita S, Kondo T. Proteomic-based identification of the APC-binding protein EB1 as a candidate of novel tissue biomarker and therapeutic target for colorectal cancer. J Proteomics. 2012;75(17):5342-55. Epub 2012/ 06/ 28. PMID: 22735596.[PubMed](外部リンク)
  3. Morofuji N, Ojima H, Onaya H, Okusaka T, Shimada K, Sakamoto Y, Esaki M, Nara S, Kosuge T, Asahina D, Ushigome M, Hiraoka N, Nagino M, Kondo T. Macrophage-capping protein as a tissue biomarker for prediction of response to gemcitabine treatment and prognosis in cholangiocarcinoma. J Proteomics. 2012;75(5):1577-89. PMID: 22155129.[PubMed](外部リンク)
  4. Mimae T, Tsuta K, Maeshima A. M, Okada M, Asamura H, Kondo T, Tsuda H. Cathepsin D as a potential prognostic marker for lung adenocarcinoma. Pathol Res Pract. 2012;208(9):534-40. Epub 2012/ 07/ 25. PMID: 22824147.[PubMed](外部リンク)
  5. Mimae T, Tsuta K, Kondo T, Nitta H, Grogan T. M, Okada M, Asamura H, Tsuda H. Protein expression and gene copy number changes of receptor tyrosine kinase in thymomas and thymic carcinomas. Ann Oncol. 2012;23(12):3129-37. Epub 2012/ 06/ 16. PMID: 22700994.[PubMed](外部リンク)
  6. Kubota D, Okubo T, Saito T, Suehara Y, Yoshida A, Kikuta K, Tsuda H, Katai H, Shimada Y, Kaneko K, Kawai A, Kondo T. Validation study on Pfetin and ATP-dependent RNA helicase DDX39 as prognostic biomarkers in gastrointestinal stromal tumour. Jpn J Clin Oncol. 2012;42(8):730-41. Epub 2012/ 06/ 23. PMID: 22723667.[PubMed](外部リンク)
  7. Kikuta K, Kubota D, Saito T, Orita H, Yoshida A, Tsuda H, Suehara Y, Katai H, Shimada Y, Toyama Y, Sato K, Kaneko K, Beppu Y, Murakami Y, Kawai A, Kondo T. Clinical proteomics identified ATP-dependent RNA helicase DDX39 as a novel biomarker to predict poor prognosis of patients with gastrointestinal stromal tumor. J Proteomics. 2012;75(4):1089-98. PMID: 22119546.[PubMed](外部リンク)
  8. Ito A, Mimae T, Yamamoto Y. S, Hagiyama M, Nakanishi J, Ito M, Hosokawa Y, Okada M, Murakami Y, Kondo T. Novel application for pseudopodia proteomics using excimer laser ablation and two-dimensional difference gel electrophoresis. Lab Invest. 2012;92(9):1374-85. Epub 2012/ 07/ 04. PMID: 22751350.[PubMed](外部リンク)
  9. Huang C, Ding G, Gu C, Zhou J, Kuang M, Ji Y, He Y, Kondo T, Fan J. Decreased Selenium-Binding Protein 1 Enhances Glutathione Peroxidase 1 Activity and Downregulates HIF-1α to Promote Hepatocellular Carcinoma Invasiveness. Clin Cancer Res. 2012;18(11):3042-53. PMID: 22512980.[PubMed](外部リンク)
  10. Hosako M, Muto T, Nakamura Y, Tsuta K, Tochigi N, Tsuda H, Asamura H, Tomonaga T, Kawai A, Kondo T. Proteomic study of malignant pleural mesothelioma by laser microdissection and two-dimensional difference gel electrophoresis identified cathepsin D as a novel candidate for a differential diagnosis biomarker. J Proteomics. 2012;75(3):833-44. Epub 2011/ 11/ 05. PMID: 22051404.[PubMed](外部リンク)
  11. Fujii K, Suzuki N, Ikeda K, Hamada T, Yamamoto T, Kondo T, Iwatsuki K. Proteomic study identified HSP 70 kDa protein 1A as a possible therapeutic target, in combination with histone deacetylase inhibitors, for lymphoid neoplasms. J Proteomics. 2012;75(4):1401-10. PMID: 22123078.[PubMed](外部リンク)

2011年

  1. Suehara Y, Tochigi N, Kubota D, Kikuta K, Nakayama R, Seki K, Yoshida A, Ichikawa H, Hasegawa T, Kaneko K, Chuman H, Beppu Y, Kawai A, Kondo T. Secernin-1 as a novel prognostic biomarker candidate of synovial sarcoma revealed by proteomics. J Proteomics. 2011;74(6):829-42. PMID: 21385630.[PubMed](外部リンク)
  2. Muto T, Taniguchi H, Kushima R, Tsuda H, Yonemori H, Chen C, Sugihara Y, Sakamoto K, Kobori Y, Palmer H, Nakamura Y, Tomonaga T, Tanaka H, Mizushima H, Fujita S, Kondo T. Global expression study in colorectal cancer on proteins with alkaline isoelectric point by two-dimensional difference gel electrophoresis. J Proteomics. 2011;74(6):858-73. PMID: 21385629.[PubMed](外部リンク)
  3. Mimae T, Tsuta K, Takahashi F, Yoshida A, Kondo T, Murakami Y, Okada M, Takeuchi M, Asamura H, Tsuda H. Steroid receptor expression in thymomas and thymic carcinomas. Cancer. 2011;117(19):4396-405. PMID: 21437890.[PubMed](外部リンク)
  4. Kubota D, Orita H, Yoshida A, Gotoh M, Kanda T, Tsuda H, Hasegawa T, Katai H, Shimada Y, Kaneko K, Kawai A, Kondo T. Pfetin as a prognostic biomarker for gastrointestinal stromal tumor: validation study in multiple clinical facilities. Jpn J Clin Oncol. 2011;41(10):1194-202. PMID: 21903705.[PubMed](外部リンク)
  5. Hagiwara T, Saito Y, Nakamura Y, Tomonaga T, Murakami Y, Kondo T. Combined use of a solid-phase hexapeptide ligand library with liquid chromatography and two-dimensional difference gel electrophoresis for intact plasma proteomics. Int J Proteomics. 2011;2011:739615. PMID: 22389768.[PubMed](外部リンク)
  6. Gotoh M, Arai E, Wakai-Ushijima S, Hiraoka N, Kosuge T, Hosoda F, Shibata T, Kondo T, Yokoi S, Imoto I, Inazawa J, Kanai Y. Diagnosis and prognostication of ductal adenocarcinomas of the pancreas based on genome-wide DNA methylation profiling by bacterial artificial chromosome array-based methylated CpG island amplification. J Biomed Biotechnol. 2011;2011:780836. PMID: 21197409.[PubMed](外部リンク)
  7. Arai E, Wakai-Ushijima S, Fujimoto H, Hosoda F, Shibata T, Kondo T, Yokoi S, Imoto I, Inazawa J, Hirohashi S, Kanai Y. Genome-wide DNA methylation profiles in renal tumors of various histological subtypes and non-tumorous renal tissues. Pathobiology. 2011;78(1):1-9. PMID: 21474971.[PubMed](外部リンク)

2010年

  1. Shibata T, Kokubu A, Miyamoto M, Hosoda F, Gotoh M, Tsuta K, Asamura H, Matsuno Y, Kondo T, Imoto I, Inazawa J, Hirohashi S. DEK oncoprotein regulates transcriptional modifiers and sustains tumor initiation activity in high-grade neuroendocrine carcinoma of the lung. Oncogene. 2010;29(33):4671-81. PMID: 20543864.[PubMed](外部リンク)
  2. Ojima H, Yoshikawa D, Ino Y, Shimizu H, Miyamoto M, Kokubu A, Hiraoka N, Morofuji N, Kondo T, Onaya H, Okusaka T, Shimada K, Sakamoto Y, Esaki M, Nara S, Kosuge T, Hirohashi S, Kanai Y, Shibata T. Establishment of six new human biliary tract carcinoma cell lines and identification of MAGEH1 as a candidate biomarker for predicting the efficacy of gemcitabine treatment. Cancer Sci. 2010;101(4):882-8. PMID: 20088962.[PubMed](外部リンク)
  3. Nishiyama N, Arai E, Chihara Y, Fujimoto H, Hosoda F, Shibata T, Kondo T, Tsukamoto T, Yokoi S, Imoto I, Inazawa J, Hirohashi S, Kanai Y. Genome-wide DNA methylation profiles in urothelial carcinomas and urothelia at the precancerous stage. Cancer Sci. 2010;101(1):231-40. PMID: 19775289.[PubMed](外部リンク)
  4. Kikuta K, Tochigi N, Saito S, Shimoda T, Morioka H, Toyama Y, Hosono A, Suehara Y, Beppu Y, Kawai A, Hirohashi S, Kondo T. Peroxiredoxin 2 as a chemotherapy responsiveness biomarker candidate in osteosarcoma revealed by proteomics. Proteomics Clin Appl. 2010;4(5):560-7. PMID: 21137073.[PubMed](外部リンク)
  5. Kikuta K, Gotoh M, Kanda T, Tochigi N, Shimoda T, Hasegawa T, Katai H, Shimada Y, Suehara Y, Kawai A, Hirohashi S, Kondo T. Pfetin as a prognostic biomarker in gastrointestinal stromal tumor: novel monoclonal antibody and external validation study in multiple clinical facilities. Jpn J Clin Oncol. 2010;40(1):60-72. PMID: 19815537.[PubMed](外部リンク)
  6. Akishima-Fukasawa Y, Ino Y, Nakanishi Y, Miura A, Moriya Y, Kondo T, Kanai Y, Hirohashi S. Significance of PGP9.5 expression in cancer-associated fibroblasts for prognosis of colorectal carcinoma. Am J Clin Pathol. 2010;134(1):71-9. PMID: 20551269.[PubMed](外部リンク)

2009年

  1. Yamada M, Fjii K, Koyama K, Hirohashi S, Kondo T. The proteomic profile of pancreatic cancer cell lines corresponding to carcinogenesis and metastasis. J Proteomics Bioinform. 2009;2(1):1-18. PMID: 1000057.(外部リンク)
  2. Uemura N, Nakanishi Y, Kato H, Saito S, Nagino M, Hirohashi S, Kondo T. Transglutaminase 3 as a prognostic biomarker in esophageal cancer revealed by proteomics. Int J Cancer. 2009;124(9):2106-15. PMID: 19142970.[PubMed](外部リンク)
  3. Uemura N, Nakanishi Y, Kato H, Nagino M, Hirohashi S, Kondo T. Antibody-based proteomics for esophageal cancer: Identification of proteins in the nuclear factor-kappaB pathway and mitotic checkpoint. Cancer Sci. 2009;100(9):1612-22. PMID: 19558549.[PubMed](外部リンク)
  4. Tsuta K, Kato Y, Tochigi N, Hoshino T, Takeda Y, Hosako M, Maeshima A. M, Asamura H, Kondo T, Matsuno Y. Comparison of different clones (WT49 versus 6F-H2) of WT-1 antibodies for immunohistochemical diagnosis of malignant pleural mesothelioma. Appl Immunohistochem Mol Morphol. 2009;17(2):126-30. PMID: 19516197.[PubMed](外部リンク)
  5. Suehara Y, Kikuta K, Nakayama R, Fujii K, Ichikawa H, Shibata T, Seki K, Hasegawa T, Gotoh M, Tochigi N, Shimoda T, Shimada Y, Sano T, Beppu Y, Kurosawa H, Hirohashi S, Kawai A, Kondo T. Anatomic site-specific proteomic signatures of gastrointestinal stromal tumors. Proteomics Clin Appl. 2009;3(5):584-96.(外部リンク)
  6. Suehara Y, Kikuta K, Nakayama R, Fujii K, Ichikawa H, Shibata T, Seki K, Hasegawa T, Gotoh M, Tochigi N, Shimoda T, Shimada Y, Sano T, Beppu Y, Kurosawa H, Hirohashi S, Kawai A, Kondo T. GST-P1 as a hitological biomarker of synovial sarcoma revealed by proteomics. Proteomics Clin Appl. 2009;3(5):623-34.(外部リンク)
  7. Kosaihira S, Tsunehiro Y, Tsuta K, Tochigi N, Gemma A, Hirohashi S, Kondo T. Proteome expression database of lung adenocarcinoma: a segment of the genome medicine database of Japan proteomics. J Proteomics Bioinform. 2009;2(11):463-5. PMID: 1000106.(外部リンク)
  8. Kondo T, Hirohashi S. Application of 2D-DIGE in cancer proteomics toward personalized medicine. Methods Mol Biol. 2009;577:135-54. PMID: 19718514.[PubMed](外部リンク)
  9. Kikuta K, Tsunehiro Y, Yoshida A, Tochigi N, Hirohashi S, Kawai A, Kondo T. Proteome expression database of Ewing sarcoma: a segment of the genome medicine database of Japan proteomics. J Proteomics Bioinform. 2009;2(12):500-4. PMID: 1000112.(外部リンク)
  10. Kikuta K, Tochigi N, Shimoda T, Yabe H, Morioka H, Toyama Y, Hosono A, Beppu Y, Kawai A, Hirohashi S, Kondo T. Nucleophosmin as a candidate prognostic biomarker of Ewing's sarcoma revealed by proteomics. Clin Cancer Res. 2009;15(8):2885-94. PMID: 19351769.[PubMed](外部リンク)
  11. Harada C, Tajima H, Hirohashi S, Kondo T. Toward high performance western blotting using vacuum-driven system and laser scanner; comparison between two signal detection methods based on chemiluminescent and immunofluorescent imaging. J Electrophoresis. 2009;53(63).(外部リンク)
  12. Arai E, Ushijima S, Gotoh M, Ojima H, Kosuge T, Hosoda F, Shibata T, Kondo T, Yokoi S, Imoto I, Inazawa J, Hirohashi S, Kanai Y. Genome-wide DNA methylation profiles in liver tissue at the precancerous stage and in hepatocellular carcinoma. Int J Cancer. 2009;125(12):2854-62. PMID: 19569176.[PubMed](外部リンク)
  13. Arai E, Ushijima S, Fujimoto H, Hosoda F, Shibata T, Kondo T, Yokoi S, Imoto I, Inazawa J, Hirohashi S, Kanai Y. Genome-wide DNA methylation profiles in both precancerous conditions and clear cell renal cell carcinomas are correlated with malignant potential and patient outcome. Carcinogenesis. 2009;30(2):214-21. PMID: 19037089.[PubMed](外部リンク)

2008年

  1. Suehara Y, Kondo T, Seki K, Shibata T, Fujii K, Gotoh M, Hasegawa T, Shimada Y, Sasako M, Shimoda T, Kurosawa H, Beppu Y, Kawai A, Hirohashi S. Pfetin as a prognostic biomarker of gastrointestinal stromal tumors revealed by proteomics. Clin Cancer Res. 2008;14(6):1707-17. PMID: 18347171.[PubMed](外部リンク)
  2. Saito S, Ojima H, Ichikawa H, Hirohashi S, Kondo T. Molecular background of alpha-fetoprotein in liver cancer cells as revealed by global RNA expression analysis. Cancer Sci. 2008;99(12):2402-9. PMID: 19038010.[PubMed](外部リンク)
  3. Orimo T, Ojima H, Hiraoka N, Saito S, Kosuge T, Kakisaka T, Yokoo H, Nakanishi K, Kamiyama T, Todo S, Hirohashi S, Kondo T. Proteomic profiling reveals the prognostic value of adenomatous polyposis coli-end-binding protein 1 in hepatocellular carcinoma. Hepatology. 2008;48(6):1851-63. PMID: 18937283.[PubMed](外部リンク)
  4. Arai E, Ushijima S, Tsuda H, Fujimoto H, Hosoda F, Shibata T, Kondo T, Imoto I, Inazawa J, Hirohashi S, Kanai Y. Genetic clustering of clear cell renal cell carcinoma based on array-comparative genomic hybridization: its association with DNA methylation alteration and patient outcome. Clin Cancer Res. 2008;14(17):5531-9. PMID: 18765545.[PubMed](外部リンク)

2007年

  1. Katoh H, Ojima H, Kokubu A, Saito S, Kondo T, Kosuge T, Hosoda F, Imoto I, Inazawa J, Hirohashi S, Shibata T. Genetically distinct and clinically relevant classification of hepatocellular carcinoma: putative therapeutic targets. Gastroenterology. 2007 Nov;133(5):1475-86. PubMed PMID: 17983802.[PubMed](外部リンク)
  2. Kakisaka T, Kondo T, Okano T, Fujii K, Honda K, Endo M, Tsuchida A, Aoki T, Itoi T, Moriyasu F, Yamada T, Kato H, Nishimura T, Todo S, Hirohashi S. Plasma proteomics of pancreatic cancer patients by multi-dimensional liquid chromatography and two-dimensional difference gel electrophoresis (2D-DIGE):up-regulation of leucine-rich alpha-2-glycoprotein in pancreatic cancer. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jun 1;852(1-2):257-67. Epub2007 Feb 1. PubMed PMID: 17303479.[PubMed](外部リンク)
  3. Yokoo H, Kondo T, Okano T, Nakanishi K, Sakamoto M, Kosuge T, Todo S, Hirohashi S. Protein expression associated with early intrahepatic recurrence of hepatocellular carcinoma after curative surgery. Cancer Sci. 2007 May;98(5):665-73. Epub 2007 Mar 28. PubMed PMID: 17391314.[PubMed](外部リンク)
  4. Okano T, Kondo T, Fujii K, Nishimura T, Takano T, Ohe Y, Tsuta K, Matsuno Y, Gemma A, Kato H, Kudoh S, Hirohashi S. Proteomic signature corresponding to the response to gefitinib (Iressa, ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor in lung adenocarcinoma. Clin Cancer Res. 2007 Feb 1;13(3):799-805. PubMed PMID: 17289870.[PubMed](外部リンク)
  5. Kondo T, HirohashiS.Application of highly sensitive fluorescent dyes (CyDye DIGE Fluor saturation dyes) to laser microdissection and two-dimensional difference gel electrophoresis (2D-DIGE) for cancerproteomics. Nat Protoc. 2007;1(6):2940-56. PubMed PMID: 17406554.[PubMed](外部リンク)

2006年

  1. Suehara Y, Kondo T, Fujii K, Hasegawa T, Kawai A, Seki K, Beppu Y, Nishimura T, Kurosawa H, Hirohashi S. Proteomic signatures corresponding to histological classification and grading of soft-tissue sarcomas. Proteomics. 2006;6(15):4402-9. PMID: 16807943.[PubMed](外部リンク)
  2. Okano T, Kondo T, Kakisaka T, Fujii K, Yamada M, Kato H, Nishimura T, Gemma A, Kudoh S, Hirohashi S. Plasma proteomics of lung cancer by a linkage of multi-dimensional liquid chromatography and two-dimensional difference gel electrophoresis. Proteomics. 2006;6(13):3938-48. PMID: 16767791.[PubMed](外部リンク)
  3. Hatakeyama H, Kondo T, Fujii K, Nakanishi Y, Kato H, Fukuda S, Hirohashi S. Protein clusters associated with carcinogenesis, histological differentiation and nodal metastasis in esophageal cancer. Proteomics. 2006;6(23):6300-16. PMID: 17133371.[PubMed](外部リンク)
  4. Fujii K, Kondo T, Yokoo H, Okano T, Yamada M, Yamada T, Iwatsuki K, Hirohashi S. Database of two-dimensional polyacrylamide gel electrophoresis of proteins labeled with CyDye DIGE Fluor saturation dye. Proteomics. 2006;6(5):1640-53. PMID: 16429455.[PubMed](外部リンク)
  5. Fujii K, Kondo T, Yamada M, Iwatsuki K, Hirohashi S. Toward a comprehensive quantitative proteome database: protein expression map of lymphoid neoplasms by 2-D DIGE and MS. Proteomics. 2006;6(17):4856-76. PMID: 16888764.[PubMed](外部リンク)

2005年

  1. Shibata T, Uryu S, Kokubu A, Hosoda F, Ohki M, Sakiyama T, Matsuno Y, Tsuchiya R, Kanai Y, Kondo T, Imoto I, Inazawa J, Hirohashi S. Genetic classification of lung adenocarcinoma based on array-based comparative genomic hybridization analysis: its association with clinicopathologic features. Clin Cancer Res. 2005;11(17):6177-85. PMID: 16144918.[PubMed](外部リンク)
  2. Seike M, Kondo T, Fujii K, Okano T, Yamada T, Matsuno Y, Gemma A, Kudoh S, Hirohashi S. Proteomic signatures for histological types of lung cancer. Proteomics. 2005;5(11):2939-48. PMID: 15996008.[PubMed](外部リンク)
  3. Naishiro Y, Yamada T, Idogawa M, Honda K, Takada M, Kondo T, Imai K, Hirohashi S. Morphological and transcriptional responses of untransformed intestinal epithelial cells to an oncogenic beta-catenin protein. Oncogene. 2005;24(19):3141-53. PMID: 15735679.[PubMed](外部リンク)
  4. Mori Y, Kondo T, Yamada T, Tsuchida A, Aoki T, Hirohashi S. Two-dimensional electrophoresis database of fluorescence-labeled proteins of colon cancer cells. J Chromatogr B Analyt Technol Biomed Life Sci. 2005;823(2):82-97. PMID: 16011914.[PubMed](外部リンク)
  5. Katoh H, Shibata T, Kokubu A, Ojima H, Loukopoulos P, Kanai Y, Kosuge T, Fukayama M, Kondo T, Sakamoto M, Hosoda F, Ohki M, Imoto I, Inazawa J, Hirohashi S. Genetic profile of hepatocellular carcinoma revealed by array-based comparative genomic hybridization: identification of genetic indicators to predict patient outcome. J Hepatol. 2005;43(5):863-74. PMID: 16139920.[PubMed](外部リンク)
  6. Fujii K, Kondo T, Yokoo H, Yamada T, Matsuno Y, Iwatsuki K, Hirohashi S. Protein expression pattern distinguishes different lymphoid neoplasms. Proteomics. 2005;5(16):4274-86. PMID: 16206328.[PubMed](外部リンク)
  7. Fujii K, Kondo T, Yokoo H, Yamada T, Iwatsuki K, Hirohashi S. Proteomic study of human hepatocellular carcinoma using two-dimensional difference gel electrophoresis with saturation cysteine dye. Proteomics. 2005;5(5):1411-22. PMID: 15751005.[PubMed](外部リンク)

2004年

  1. Yokoo H, Kondo T, Fujii K, Yamada T, Todo S, Hirohashi S. Proteomic signature corresponding to alpha fetoprotein expression in liver cancer cells. Hepatology. 2004;40(3):609-17. PMID: 15349899.[PubMed](外部リンク)
  2. Seike M, Kondo T, Fujii K, Yamada T, Gemma A, Kudoh S, Hirohashi S. Proteomic signature of human cancer cells. Proteomics. 2004;4(9):2776-88. PMID: 15352251.[PubMed](外部リンク)
  3. Honda K, Yamada T, Seike M, Hayashida Y, Idogawa M, Kondo T, Ino Y, Hirohashi S. Alternative splice variant of actinin-4 in small cell lung cancer. Oncogene. 2004;23(30):5257-62. PMID: 15122314.[PubMed](外部リンク)

2003年

  1. Yamada T, Mori Y, Hayashi R, Takada M, Ino Y, Naishiro Y, Kondo T, Hirohashi S. Suppression of intestinal polyposis in Mdr1-deficient ApcMin/+ mice. Cancer Res. 2003;63(5):895-901. PMID: 12615699.[PubMed](外部リンク)
  2. Seike M, Kondo T, Mori Y, Gemma A, Kudoh S, Sakamoto M, Yamada T, Hirohashi S. Proteomic analysis of intestinal epithelial cells expressing stabilized beta-catenin. Cancer Res. 2003;63(15):4641-7. PMID: 12907644.[PubMed](外部リンク)
  3. Kondo T, Seike M, Mori Y, Fujii K, Yamada T, Hirohashi S. Application of sensitive fluorescent dyes in linkage of laser microdissection and two-dimensional gel electrophoresis as a cancer proteomic study tool. Proteomics. 2003;3(9):1758-66. PMID: 12973736.[PubMed](外部リンク)