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Division of Cancer Differentiation
Recent research in many laboratories has revealed the importance of cancer stem cells during development of refractory cancer with highly metastatic potential. In our division, we focus on studying dynamic regulation of stem cell-related characteristics during cancer development. The Main goals of our research center around elucidation of the biological properties of cancer stem cells, and understanding mechanisms of how such cells develop from normal tissues. We take several experimental approaches to address these issues including single-cell gene expression analyses and CRISPR-based functional screening.