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Research Papers

Selected Original article

  1. Igarashi T, Mazevet M, Yasuhara T, Yano K, Mochizuki A, Nishino M, Yoshida T, Yoshida Y, Takamatsu N, Shiraishi K, Horinouchi H, Kohno T, Hamamoto R, Adachi J, Zou L and *Shiotani B, An ATR-PrimPol pathway confers tolerance to oncogenic KRAS-induced and heterochromatin-associated replication stress, Nature Communications, 14(1): 4991; 2023 DOI: 10.1038/s41467-023-40578-2 PMID: 37591859 (https://pubmed.ncbi.nlm.nih.gov/37591859/)
  2. Uchida C, Niida H, Sakai S, Iijina K, Kitagawa K, Ohhata T, Shiotani B, and Kitagawa M, p130RB2 positively contributes to ATR activation in response to replication stress via the RPA32-ETAA1 axis, Biochim Biophys Acta Mol Cell Res. 1870: 119484; doi.org/10.1016/j.bbamcr.2023.119484; 2023 PMID: 37201767 (https://pubmed.ncbi.nlm.nih.gov/37201767/)
  3. Yano K, Takahashi R, Shiotani B, Abe J, Shidooka T, Sudo Y, Yamamoto Y, Kan S, Sakagami H, Tahara H. PRPF19 regulates p53-dependent cellular senescence by modulating alternative splicing of MDM4 mRNA Biol Chem; 297(1):100882.2021 doi: 10.1016/j.jbc.2021.100882.PMID:34144037(https://pubmed.ncbi.nlm.nih.gov/34144037/)
  4. Kurashima K, Kashiwagi H, Shimomura I, Suzuki A, Takeshita F, Mazevet M, Harata M, Yamashita T., Yamamoto Y, Kohno T., *Shiotani B., SMARCA4 deficiency-associated heterochromatin induces intrinsic DNA replication stress and susceptibility to ATR inhibition in lung adenocarcinoma. NAR Cancer; 2: 2020. doi.org/10.1093/narcan/zcaa005. PMID: 34316685(https://pubmed.ncbi.nlm.nih.gov/34316685/)
  5. Yasuhara T, Kato R, Hagiwara Y, Shiotani B, Yamauchi M, Nakada S, Shibata A, Miyagawa K. Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination Repair. Cell;175 :558-570. 2018 doi: 10.1016/j.cell.2018.08.056. PMID: 30245011(https://pubmed.ncbi.nlm.nih.gov/30245011/)
  6. Asano N, Yoshida A, Mitani S, Kobayashi E, Shiotani B, Komiyama M, Fujimoto H, Chuman H, Morioka H, Matsumoto M, Nakamura M, Kubo T, Kato M, Kohno T, Kawai A, Kondo T, Ichikawa H. Frequent amplification of receptor tyrosine kinase genes in welldifferentiated/ dedifferentiated liposarcoma.Oncotarget. 8 : 12941-12952 doi: 10.18632/oncotarget.14652; 2017. PMID: 28099935 (https://pubmed.ncbi.nlm.nih.gov/28099935/)
  7. Matsunuma R, Niida H, Ohhata T, Kitagawa K, Sakai S, Uchida C, Shiotani B, Matsumoto M, Nakayama KI, Ogura H, Shiiya N, Kitagawa M.UV Damage-Induced Phosphorylation of HBO1 Triggers CRL4DDB2-Mediated Degradation To Regulate Cell Proliferation.
  8. Mol Cell Biol. 36: 394-406; 2015. PMID: 26572825(https://pubmed.ncbi.nlm.nih.gov/26572825/)
  9. Hirokawa T., B, Shimada M., Murata K., Johmura Y., Haruta M., Tahara H., Takeyama H., and *Nakanishi M., CBP-93872 is an inhibitor of NBS1-mediated ATR activation that abrogates maintenance of the DNA-double-stranded break-specific G2 checkpoint. Cancer Res., 74: 3880-3889, 2014. PMID: 24876101(https://pubmed.ncbi.nlm.nih.gov/24876101/)
  10. *Shiotain B., Nguyen H.D., Håkansson P., Maréchal A, Tse A., Tahara H., and *Zou L, Two Distinct Modes of ATR Activation Orchestrated by Rad17 and Nbs1. Cell Reports, 3: 1651-1662; 2013. PMID: 23684611(https://pubmed.ncbi.nlm.nih.gov/23684611/)
  11. Ogiwara H, Ui A, Shiotani B, Zou L, Yasui A, *Kohno T. Curcumin suppresses multiple DNA damage response pathways and has potency as a sensitizer to PARP inhibitor. Carcinogenesis. 34: 2486-2497; 2013. PMID: 23825154(https://pubmed.ncbi.nlm.nih.gov/23825154/)
    Chiba N, Comaills V, Shiotani B, Takahashi F, Shimada T, Tajima K, Winokur D, Hayashida T, Willers H, Brachtel E, Vivanco M, Haber D, *Zou L, and *Maheswaran S, HOXB9 induces EMT-associated radioresistance by promoting activation of the ATM pathway. Natl. Acad. Sci. USA 109: 2760-2765; 2012. PMID: 21930940 (https://pubmed.ncbi.nlm.nih.gov/21930940/)
  12. Liu S1, Shiotani B1, Lahiri M, Maréchal A, Tse A, Yang XH, and *Zou L, ATR Autophosphorylation as a Molecular Switch for Checkpoint Activation.
    Mol. Cell, 43: 192-202; 2011 1These authors are equally contributed. PMID: 21777809(https://pubmed.ncbi.nlm.nih.gov/21777809/)
  13. Huang M1, Kim J. M1, Shiotani B, Yang K, Zou L, and *D’Andrea D. A, The FANCM/FAAP24 Complex is Required for the DNA Interstrand Crosslink-Specific Checkpoint Response
    Mol. Cell, 39: 259-268; 2010 1These authors are equally contributed. PMID: 20670894(https://pubmed.ncbi.nlm.nih.gov/20670894/)
  14. Shiotani B, and *Zou L. Single-Stranded DNA as an ATM-to-ATR Switch at DNA Breaks. Cell, 33: 547-558; 2009. PMID: 19285939(https://pubmed.ncbi.nlm.nih.gov/19285939/)
  15. Yang XH, Shiotani B, Classon M, *Zou L., Chk1 and Claspin potentiate PCNA ubiquitination. Genes Dev., 22:1147-1152; 2008. PMID: 18451105(https://pubmed.ncbi.nlm.nih.gov/18451105/)

Review article

  1. Yano K, and *Shiotani B, Emerging strategies for cancer therapy by ATR inhibitors, Cancer Science, 114(7):2709-2721,2023 DOI:10.1111/cas.15845 PMID:37189251(https://pubmed.ncbi.nlm.nih.gov/37189251/)
  2. *Shiotani B and *Zou L. Signaling of DNA Replication Stress through the ATR Checkpoint. In Hanaoka F. and Sugasawa K. (ed.) DNA Replication, Recombination and Repair - Molecular Mechanisms and Pathology, Springer, 405-428, 2016. DOI: 10.1007/978-4-431-55873-6_16(https://link.springer.com/chapter/10.1007/978-4-431-55873-6_16)
  3. Shiotani B, and *Zou L., A Human Cell Extract-Based Assay for the Activation of ATM and ATR Checkpoint Kinases Willis X. Li (ed) Methods in Molecular Biology, Cell Cycle Checkpoints: Methods and Protocols, New York, Humana Press, 782:181-191; 2011. PMID: 21870292(https://pubmed.ncbi.nlm.nih.gov/21870292/)
  4. Shiotani B and *Zou L., ATR signaling at a glance. J Cell Sci., 22: 301-304, 2009. PMID: 19158338(https://pubmed.ncbi.nlm.nih.gov/19158338/)