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EPOC Project
Definition of the EPOC projects
- Research managed by the Department of Strategic Programs of EPOC
- Research composed of multiple basic and clinical departments
Requirements for the EPOC projects
- Clarify the clinical derivation including clinical research
- Aim to derive the basic and clinical results to companies
- Clarify the research period and achievement goals
Information of the EPOC Projects
Project for Resistance to Cancer Therapies
- Establishment of SOPs for generation of cell lines from clinical samples or PDX models to investigate resistance to cancer therapies
- Multiomics analysis, including single-cell analysis using existing or newly established cell lines
- Multiomics analysis, including single-cell analysis using PDX and clinical samples
- Validation of mechanisms of resistance identified by multiomics approaches
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Project for Medical Device Development
- Install of equipment for prototyping and acquisition of non-clinical POC
- Establishment of system for Research fund acquisition, intellectual property strategy and regulatory strategy
- Establishment of the base technology for various types of academia seeds
- Collaboration with medical device company
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Project for Co-clinical Trials
- Establishment of SOPs for non-clinical models and quality control
- Generation of non-clinical models from biopsy specimen
- Establishment of co-clinical trial systems
- Start of co-clinical trials
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Project for Supportive Care Research
- Bilateral translational research from academia to companies and from companies to academia
- License out compounds derived from academia to companies
- Support of phase I and II study regarding supportive and palliative care fields
- Cooperation with the supportive and palliative care research support office
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- Yasuhito UEZONO /Project for Supportive Care Research（NCC-EPOC）
Project for Prevention of HPV-related Cancer
- Development of Adenovirus vector expressing Cas9 nickase and 8x gRNA targeting HPV DNA
- Demonstration of POC in in vitro and in vivo models
- Production of GMP-grade adenovirus vector
- Framework construction for a clinical trial targeting HPV +ve HNSCC
- Start of the clinical trial
- Framework construction for a clinical trial targeting other HPV-related diseases including CIN and cervical cancer
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Project for Fully Automatic Specimen Preparation
- Feasibility study for processing equipment and full automatic embedding machine
- Equivalence study for processing equipment and fully automated embedding machine compared to conventional method
- Feasibility study for fully automated thin sectioning, staining, and sealing machines
- Equivalence study for fully automatic thin sectioning machine, staining machine and sealing machine compared with conventional method