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Department of Genetic Medicine and Services
Takeshi Kuwata, Toshihiko Doi, Kazuya Tsuchihara, Takahiro Kogawa, Kenichi Harano, Shingo Matsumoto, Shigehisa Yoshida
Introduction
The Department of Genetic Medicine and Services was newly established in May 2016. The aim of this department is to deal with genetic and genomic testings and their related issues including genetic counseling conducted in the National Cancer Center Hospital East (NCCHE).
Our team and what we do
The aim of the Department of Genetic Medicine and Services is to deal with the following subjects.
1)Genetic counseling
2)Genetic/genomic testings
3)Ethical issue related to genetic/genomic medicine
4)Education of genetic/genomic medicine
5)Regulation of storage and usage of genetic/genomic information
6)Other genetic/genomic medicine
For this purpose, our department, as a multi-disciplinary team, consists of medical doctors, nurses, and medical technicians from different clinical departments as well as research laboratories. Our Outpatient Genetic Counseling Clinic for familial tumors provides genetic counseling and genetic testing for cancer patients and their relatives. In 2016, 27 new clients visited the clinic, and 47 counseling sessions and 17 genetic testings were provided.
Figure 1. Organization of Department of Genetic Medicine and Services
Research activities
The Outpatient Genetic Counseling Clinic for familial tumors is participating in the NCC Research and Development Fund program (25-A-1), and provides genetic testings.
Clinical trials
The Outpatient Genetic Counseling Clinic for familial tumors supports and provides genetic counseling for patients willing to participate in clinical trials where genetic tests are required.
Education
We educate medical doctors who wish to be a board-certified genetician by attending the Outpatient Genetic Counseling Clinic. We also provide intramural educational seminar for medical doctors and co-medicals for being familiar with genetic and genomic medicine to provide precision medicine for all the cancer patients and their families visiting our hospital.
Future prospects
Our department will continue to provide genetic counseling and testing for possible familial cancer patients/families. We will also continue to conduct education programs for medical doctors and paramedics working for the NCCHE to provide precision medicine in clinics. The Department of Genetic Medicine and Services will also establish genomic testing pipeline from research to clinic for accelerating development of medical and diagnostic devices for genome medicine.
List of papers published in 2016
Journal
1.Kuboki Y, Yamashita S, Niwa T, Ushijima T, Nagatsuma A, Kuwata T, Yoshino T, Doi T, Ochiai A, Ohtsu A. Comprehensive analyses using next-generation sequencing and immunohistochemistry enable precise treatment in advanced gastric cancer. Ann Oncol, 27:127-133, 2016
2.Yokoyama T, Nakatake M, Kuwata T, Couzinet A, Goitsuka R, Tsutsumi S, Aburatani H, Valk PJM, Delwel R, Nakamura T. MEIS1-mediated transactivation of synaptotagmin-like 1 promotes CXCL12/CXCR4 signaling and leukemogenesis. J Clin Invest, 126:1664-1678, 2016
3.Hisakane K, Saruwatari K, Fujii S, Kirita K, Umemura S, Matsumoto S, Yoh K, Niho S, Ohmatsu H, Kuwata T, Ochiai A, Gemma A, Tsuboi M, Goto K, Ishii G. Unique intravascular tumor microenvironment predicting recurrence of lung squamous cell carcinoma. J Cancer Res Clin Oncol, 142:593-600, 2016
4.Sekihara K, Hishida T, Ikemura S, Saruwatari K, Morise M, Kuwata T, Fujii S, Kojima M, Ochiai A, Funai K, Aokage K, Yoshida J, Tsuboi M, Ishii G. The association of intravascular stromal cells with prognosis in high-grade neuroendocrine carcinoma of the lung. J Cancer Res Clin Oncol, 142:905-912, 2016
5.Saruwatari K, Ikemura S, Sekihara K, Kuwata T, Fujii S, Umemura S, Kirita K, Matsumoto S, Yoh K, Niho S, Ohmatsu H, Ochiai A, Kohrogi H, Tsuboi M, Goto K, Ishii G. Aggressive tumor microenvironment of solid predominant lung adenocarcinoma subtype harboring with epidermal growth factor receptor mutations. Lung Cancer, 91:7-14, 2016
6.Matsuzawa R, Kirita K, Kuwata T, Umemura S, Matsumoto S, Fujii S, Yoh K, Kojima M, Niho S, Ohmatsu H, Ochiai A, Tsuboi M, Goto K, Ishii G. Factors influencing the concordance of histological subtype diagnosis from biopsy and resected specimens of lung adenocarcinoma. Lung Cancer, 94:1-6, 2016
7.Suzuki S, Aokage K, Hishida T, Yoshida J, Kuwata T, Yamauchi C, Tsuboi M, Ishii G. Interstitial growth as an aggressive growth pattern in primary lung cancer. J Cancer Res Clin Oncol, 142:1591-1598, 2016
8.Naito M, Aokage K, Saruwatari K, Hisakane K, Miyoshi T, Hishida T, Yoshida J, Masato S, Kojima M, Kuwata T, Fujii S, Ochiai A, Sato Y, Tsuboi M, Ishii G. Microenvironmental changes in the progression from adenocarcinoma in situ to minimally invasive adenocarcinoma and invasive lepidic predominant adenocarcinoma of the lung. Lung Cancer, 100:53-62, 2016