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Division of Screening Technology

Takahisa Matsuda, Koichi Nagata, Masau Sekiguchi, Hidenori Kanazawa, Ken Takabayashi, Takaaki Yasuda, Hiroshi Matsumoto, Masaki Matsuoka


The Division of Screening Technology works as a part of the Screening Research Group in the Center for Public Health Sciences. The Screening Research Group is divided into two divisions (Division of Screening Assessment and Management/ Division of Screening Technology). The Division of Screening Technology consists of three staff medical doctors and five visiting researchers.

Our team and what we do

In the Division of Screening Technology, we aim to develop new diagnostic techniques that can be applied to cancer screening, as well as research existing diagnostic methods that can be applied to medical examinations. We are also assessing a new close examination method in cancer screening. In addition, we also work on research aiming at risk stratification of people to be screened.

Research activities and Clinical trials

1)We are now ongoing to examine the cancer detection rate of each screening modality (e.g. Chest CT, upper/ lower GI Endoscopy, MMG/ Tomosynthesis and Breast Ultrasonography, FDG-PET, CT-colonography), the characteristics of the detected cancer, and the false positive rate for all medical examiners who underwent cancer screening during 10 years from the establishment of our center in 2004. In addition, we aim to clarify the relationship between cancer screening and cancer death from long-term (prognosis survey) results. We published a total of three papers in this period (related to pulmonary helical CT, PET-CT, relationship between branch-chain amino acid and colorectal adenoma).

2)Oshima Study: Epidemiological research based on colonoscopy interventional colon cancer screening targeting 40 to 79 years old (4,645 people) residing in Izu-Oshima, Tokyo. We aim to register 1,500 people during the recruitment period until the year of 2017. We aim to verify the safety of screening colonoscopy and detection rate of advanced neoplasia (colorectal cancer / advanced adenoma). In addition, sensitivity analysis for colorectal cancer (advanced neoplasia) will be conducted on the standard FOBT (2-day FIT) and the four kinds of new biomarkers using blood sample.

3)In the research on CT colonography (CTC), we are continuing multi-center clinical research in addition to surveys of the actual situation throughout the country. We published four English papers this year.

Future prospects

We will promote screening development research to create evidences.

List of papers published in 2016


1.Sekiguchi M, Igarashi A, Matsuda T, Matsumoto M, Sakamoto T, Nakajima T, Kakugawa Y, Yamamoto S, Saito H, Saito Y. Optimal use of colonoscopy and fecal immunochemical test for population-based colorectal cancer screening: a cost-effectiveness analysis using Japanese data. Jpn J Clin Oncol, 46:116-125, 2016

2.Chiu H-M, Ching JYL, Wu KC, Rerknimitr R, Li J, Wu D-C, Goh KL, Matsuda T, Kim H-S, Leong R, Yeoh KG, Chong VH, Sollano JD, Ahmed F, Menon J, Sung JJY. A Risk-Scoring System Combined With a Fecal Immunochemical Test Is Effective in Screening High-Risk Subjects for Early Colonoscopy to Detect Advanced Colorectal Neoplasms. Gastroenterology, 150:617-625 e613, 2016

3.Matsumoto M, Nakajima T, Kakugawa Y, Sakamoto T, Kuribayashi S, Otake Y, Matsuda T, Kanemitsu Y, Taniguchi H, Saito Y. Surveillance using capsule endoscopy is safe in post-colectomy patients with familial adenomatous polyposis: a prospective Japanese study. Fam Cancer, 15:75-83, 2016

4.Pioche M, Matsumoto M, Takamaru H, Sakamoto T, Nakajima T, Matsuda T, Abe S, Kakugawa Y, Otake Y, Saito Y. Endocuff-assisted colonoscopy increases polyp detection rate: a simulated randomized study involving an anatomic colorectal model and 32 international endoscopists. Surg Endosc, 30:288-295, 2016

5.Watabe H, Nakamura T, Yamada A, Kakugawa Y, Nouda S, Terano A. Assessment of an electronic learning system for colon capsule endoscopy: a pilot study. J Gastroenterol, 51:579-585, 2016

6.Iwano T, Nagata K, Mima A, Egawa T, Yamashita H, Saito H. Computed Tomographic Colonography Findings in Ileocecal Tuberculosis. J Gastrointestin Liver Dis, 25:269, 2016

7.Sano Y, Tanaka S, Kudo S-E, Saito S, Matsuda T, Wada Y, Fujii T, Ikematsu H, Uraoka T, Kobayashi N, Nakamura H, Hotta K, Horimatsu T, Sakamoto N, Fu K-I, Tsuruta O, Kawano H, Kashida H, Takeuchi Y, Machida H, Kusaka T, Yoshida N, Hirata I, Terai T, Yamano H-O, Kaneko K, Nakajima T, Sakamoto T, Yamaguchi Y, Tamai N, Nakano N, Hayashi N, Oka S, Iwatate M, Ishikawa H, Murakami Y, Yoshida S, Saito Y. Narrow-band imaging (NBI) magnifying endoscopic classification of colorectal tumors proposed by the Japan NBI Expert Team. Dig Endosc, 28:526-533, 2016

8.Matsuda T, Oka S, Ikematsu H, Matsushita H-o, Mori Y, Takeuchi Y, Tamai N, Kawamura T, Chino A, Keum B, Khomvilai S, Uraoka T. Endoscopic diagnosis of colorectal serrated lesions: Current status and future perspectives based on the results of a questionnaire survey. Dig Endosc, 28 Suppl 1:35-42, 2016

9.Iwano T, Nagata K, Egawa T, Yamashita H. Appendiceal diverticulosis incidentally detected by computed tomographic colonography. Dig Liver Dis, 48:565, 2016

10.Inoki K, Nakajima T, Sekine S, Sugano K, Tsukamoto S, Yamada M, Mutoh M, Sakamoto T, Matsuda T, Sekiguchi M, Ushiama M, Yoshida T, Sakamoto H, Kanemitsu Y, Saito Y. Depressed-type submucosal invasive colorectal cancer in a patient with Lynch syndrome diagnosed using short-interval colonoscopy. Dig Endosc, 28:749-754, 2016

11.Sekiguchi M, Matsuda T, Saito Y. Surveillance after endoscopic and surgical resection of colorectal cancer. Best Pract Res Clin Gastroenterol, 30:959-970, 2016

12.Katsumata R, Matsumoto H, Motoyasu O, Murao T, Ishii M, Fujita M, Tokunaga H, Akiyama T, Wada H, Sugihara T, Shiotani A, Haruma K. Primary colorectal lymphoma comprising both components of diffuse large B-cell lymphoma and mucosa-associated lymphoid tissue lymphoma combined with cytomegalovirus colitis. Clin J Gastroenterol, 9:59-62, 2016

13.Matsumoto H, Shiotani A, Katsumata R, Fujita M, Nakato R, Murao T, Ishii M, Kamada T, Haruma K, Graham DY. Helicobacter pylori Eradication with Proton Pump Inhibitors or Potassium-Competitive Acid Blockers: The Effect of Clarithromycin Resistance. Dig Dis Sci, 61:3215-3220, 2016

14.Matsumoto H, Shiotani A, Nishibayashi H, Kamada T, Kimura T, Fujimura Y, Nakato R, Murao T, Fujita M, Haruma K. Molecular Detection of H. pylori Using Adherent Gastric Mucous to Biopsy Forceps. Helicobacter, 21:548-553, 2016

15.Murakami T, Takeda S-I, Kanazawa H, Ugajin A, Kijima S, Nakamura H, Imai T, Sugase T, Horikoshi R, Kobayashi T, Akimoto T, Saito O, Nagata D. Subclinical growth of an arteriovenous fistula associated with renal biopsy: a case report. BMC Nephrol, 17:81, 2016

16.Suzuki H, Oda I, Abe S, Sekiguchi M, Mori G, Nonaka S, Yoshinaga S, Saito Y. High rate of 5-year survival among patients with early gastric cancer undergoing curative endoscopic submucosal dissection. Gastric Cancer, 19:198-205, 2016

17.Tsuruki ES, Saito Y, Abe S, Takamaru H, Yamada M, Sakamoto T, Nakajima T, Matsuda T, Sekine S, Taniguchi H. Evaluating the efficacy and safety of a novel endoscopic fluorescence imaging modality using oral 5-aminolevulinic acid for colorectal tumors. Endosc Int Open, 4:E30-35, 2016

18.Yamada M, Saito Y, Sakamoto T, Nakajima T, Kushima R, Parra-Blanco A, Matsuda T. Endoscopic predictors of deep submucosal invasion in colorectal laterally spreading tumors. Endoscopy, 48:456-464, 2016

19.Mori Y, Kudo S-e, Ogawa Y, Wakamura K, Kudo T, Misawa M, Hayashi T, Katagiri A, Miyachi H, Inoue H, Oka S, Matsuda T. Diagnosis of sessile serrated adenomas/polyps using endocytoscopy (with videos). Dig Endosc, 28 Suppl 1:43-48, 2016

20.Matsuda T, Chiu H-M, Sano Y, Fujii T, Ono A, Saito Y. Surveillance colonoscopy after endoscopic treatment for colorectal neoplasia: From the standpoint of the Asia-Pacific region. Dig Endosc, 28:342-347, 2016

21.De Ceglie A, Hassan C, Mangiavillano B, Matsuda T, Saito Y, Ridola L, Bhandari P, Boeri F, Conio M. Endoscopic mucosal resection and endoscopic submucosal dissection for colorectal lesions: A systematic review. Crit Rev Oncol Hematol, 104:138-155, 2016

22.Takamaru H, Saito Y, Yamada M, Tsuruki ES, Kinjo Y, Otake Y, Sakamoto T, Nakajima T, Matsuda T. Clinical impact of endoscopic clip closure of perforations during endoscopic submucosal dissection for colorectal tumors. Gastrointest Endosc, 84:494-502 e491, 2016

23.Inoki K, Sakamoto T, Sekiguchi M, Yamada M, Nakajima T, Matsuda T, Saito Y. Successful endoscopic closure of a colonic perforation one day after endoscopic mucosal resection of a lesion in the transverse colon. World J Clin Cases, 4:238-242, 2016

24.Wong MCS, Ching JYL, Chiu H-M, Wu KC, Rerknimitr R, Li J, Wu D-C, Goh KL, Matsuda T, Kim H-S, Leong R, Yeoh KG, Chong VH, Sollano JD, Ahmed F, Menon J, Ng SC, Wu JCY, Chan FKL, Sung JJY. Risk of Colorectal Neoplasia in Individuals With Self-Reported Family History: A Prospective Colonoscopy Study from 16 Asia-Pacific Regions. Am J Gastroenterol, 111:1621-1629, 2016

25.Abe S, Sakamoto T, Takamaru H, Yamada M, Nakajima T, Matsuda T, Saito Y. Stenosis rates after endoscopic submucosal dissection of large rectal tumors involving greater than three quarters of the luminal circumference. Surg Endosc, 30:5459-5464, 2016

26.Sekiguchi M, Kakugawa Y, Terauchi T, Matsumoto M, Saito H, Muramatsu Y, Saito Y, Matsuda T. Sensitivity of 2-[18F]fluoro-2-deoxyglucose positron emission tomography for advanced colorectal neoplasms: a large-scale analysis of 7505 asymptomatic screening individuals. J Gastroenterol, 51:1122-1132, 2016

27.Sekiguchi M, Oda I, Taniguchi H, Suzuki H, Morita S, Fukagawa T, Sekine S, Kushima R, Katai H. Risk stratification and predictive risk-scoring model for lymph node metastasis in early gastric cancer. J Gastroenterol, 51:961-970, 2016

28.Suzuki H, Oda I, Sekiguchi M, Abe S, Nonaka S, Yoshinaga S, Saito Y. Factors associated with incomplete gastric endoscopic submucosal dissection due to misdiagnosis. Endosc Int Open, 4:E788-793, 2016

29.Takamaru H, Yamada M, Sakamoto T, Nakajima T, Saito Y, Kakugawa Y, Matsumoto M, Matsuda T, Ide D, Saito S, Gulati S, Tajiri H. Dual camera colon capsule endoscopy increases detection of colorectal lesions. Scand J Gastroenterol, 51:1532-1533, 2016