Jump to Main Contents
ncc en
HOME > Publication & Reports > Annual Report 2017 > Center for Public Health Sciences

Annual Report 2017

Division of Cohort Consortium Research

Manami Inoue, Maiko Fujimori, Shiori Tanaka, Yoko Hirose, Ryuhei Osanai

Introduction

 The Division of Cohort Consortium Research aims to create evidence for the prevention of cancer and other diseases and extending the healthy life expectancy of Japanese. It does this by conducting epidemiological research using a domestic/regional/international epidemiological research network.

Research activities

1. The Collaborative Epidemiological Research Network Project of the Six National Centers for Advanced and Specialized Medical Care (6NC Project)

 The 6NC Project is a core research project of the Division of Cohort Consortium Research. The main aim of the 6NC Project is to establish the 6NC Epidemiological Research Collaboration Platform, which will be used to conduct pooled analyses and mutual data analysis by exchange and cooperation among researchers at the six national centers. As part of this project we have established an analysis platform which offers both onsite and remote access with information security protection. We have also launched an initiative working group to make recommendations to extend the healthy life expectancy of Japanese, and for comprehensive disease prevention. This project started in 2017.

2. Asia Cohort Consortium (ACC)

 The ACC is a collaborative effort which seeks to understand the relationship between genetics, environmental exposure, and the etiology of disease through establishment of a consortium of cohort studies with healthy individuals throughout Asian countries. The ACC includes 31 cohort studies in 10 countries in Asia involving 1.5 million participants, and more than 150 researchers across Asia, US, and the world. The main missions of the ACC are: 1) to serve as a platform for cross-cohort collaborative projects and combined analysis and 2) to act as an incubator for new cohort studies in Asia. Our division serves as a coordinating center and data center of the ACC, and directs many of its ongoing projects.

3. A large-scale epidemiological study to evaluate the effectiveness of eradicating Helicobacter pylori in preventing gastric cancer in the middle-aged and elderly Japanese population

 This study aims to assess whether H.pylori eradication prevents the subsequent development of gastric cancer by establishing a pooled cohort of four large-scale epidemiological studies with information on H.pylori infection status (JPHC-NEXT in the Yokote, Saku, and Chikusei areas; the Yamagata Cohort; and the Tokyo Gastric Cancer Screening Study) targeting the middle-aged to elderly population. This project started in 2017.

4. Attributable Causes of Cancer (JAPAN PAF PROJECT)

 To contribute to evidence-based policy decision making for national cancer control, we are conducting a systematic assessment to estimate the current burden of cancer attributable to known preventable risk factors in Japan. The first estimation was conducted for cancer incidence and mortality in the year 2005. The estimation is currently being updated for the year 2015.

Education

 We have supervised the research of master and PhD students of The University of Tokyo. In addition, we have hosted a visiting scholar from Seoul National University, Korea.

Future prospects

 As well as creating scientific evidence, we will expand and strengthen research collaboration networks, both domestic and international.

List of papers published in January 2017 - March 2018

Journal

 1. Chen Y, Wu F, Saito E, Lin Y, Song M, Luu HN, Gupta PC, Sawada N, Tamakoshi A, Shu XO, Koh WP, Xiang YB, Tomata Y, Sugiyama K, Park SK, Matsuo K, Nagata C, Sugawara Y, Qiao YL, You SL, Wang R, Shin MH, Pan WH, Pednekar MS, Tsugane S, Cai H, Yuan JM, Gao YT, Tsuji I, Kanemura S, Ito H, Wada K, Ahn YO, Yoo KY, Ahsan H, Chia KS, Boffetta P, Zheng W, Inoue M, Kang D, Potter JD. Association between type 2 diabetes and risk of cancer mortality: a pooled analysis of over 771,000 individuals in the Asia Cohort Consortium. Diabetologia, 60:1022-1032, 2017

 2. Saito E, Inoue M, Tsugane S, Ito H, Matsuo K, Wakai K, Wada K, Nagata C, Tamakoshi A, Sugawara Y, Tsuji I, Mizoue T, Tanaka K, Sasazuki S. Smoking cessation and subsequent risk of cancer: A pooled analysis of eight population-based cohort studies in Japan. Cancer Epidemiol, 51:98-108, 2017

 3. Kigawa N, Budhathoki S, Yamaji T, Iwasaki M, Inoue M, Tsugane S. Association of plasma C-reactive protein level with the prevalence of colorectal adenoma: the Colorectal Adenoma Study in Tokyo. Sci Rep, 7:4456, 2017

 4. Wang C, Nishiyama T, Kikuchi S, Inoue M, Sawada N, Tsugane S, Lin Y. Changing trends in the prevalence of H. pylori infection in Japan (1908-2003): a systematic review and meta-regression analysis of 170,752 individuals. Sci Rep, 7:15491, 2017

 5. Uesugi S, Ishihara J, Iso H, Sawada N, Takachi R, Inoue M, Tsugane S. Dietary intake of antioxidant vitamins and risk of stroke: the Japan Public Health Center-based Prospective Study. Eur J Clin Nutr, 71:1179-1185, 2017

 6. Narita S, Inoue M, Saito E, Abe SK, Sawada N, Ishihara J, Iwasaki M, Yamaji T, Shimazu T, Sasazuki S, Shibuya K, Tsugane S. Dietary fiber intake and risk of breast cancer defined by estrogen and progesterone receptor status: the Japan Public Health Center-based Prospective Study. Cancer Causes Control, 28:569-578, 2017

 7. Ugai T, Matsuo K, Sawada N, Iwasaki M, Yamaji T, Shimazu T, Sasazuki S, Inoue M, Kanda Y, Tsugane S. Smoking and alcohol and subsequent risk of myelodysplastic syndromes in Japan: the Japan Public Health Centre-based Prospective Study. Br J Haematol, 178:747-755, 2017

 8. Nozue M, Shimazu T, Sasazuki S, Charvat H, Mori N, Mutoh M, Sawada N, Iwasaki M, Yamaji T, Inoue M, Kokubo Y, Yamagishi K, Iso H, Tsugane S. Fermented Soy Product Intake Is Inversely Associated with the Development of High Blood Pressure: The Japan Public Health Center-Based Prospective Study. J Nutr, 147:1749-1756, 2017

 9. Teng Y, Saito E, Abe SK, Sawada N, Iwasaki M, Yamaji T, Shimazu T, Sasazuki S, Inoue M, Tsugane S. Female reproductive factors, exogenous hormone use, and pancreatic cancer risk: the Japan Public Health Center-based prospective study. Eur J Cancer Prev, 26:378-384, 2017

10. Nomura S, Sakamoto H, Glenn S, Tsugawa Y, Abe SK, Rahman MM, Brown JC, Ezoe S, Fitzmaurice C, Inokuchi T, Kassebaum NJ, Kawakami N, Kita Y, Kondo N, Lim SS, Maruyama S, Miyata H, Mooney MD, Naghavi M, Onoda T, Ota E, Otake Y, Roth GA, Saito E, Tabuchi T, Takasaki Y, Tanimura T, Uechi M, Vos T, Wang H, Inoue M, Murray CJL, Shibuya K. Population health and regional variations of disease burden in Japan, 1990-2015: a systematic subnational analysis for the Global Burden of Disease Study 2015. Lancet, 390:1521-1538, 2017

11. Mori N, Shimazu T, Sasazuki S, Nozue M, Mutoh M, Sawada N, Iwasaki M, Yamaji T, Inoue M, Takachi R, Sunami A, Ishihara J, Sobue T, Tsugane S. Cruciferous Vegetable Intake Is Inversely Associated with Lung Cancer Risk among Current Nonsmoking Men in the Japan Public Health Center (JPHC) Study. J Nutr, 147:841-849, 2017

12. Eshak ES, Honjo K, Iso H, Ikeda A, Inoue M, Sawada N, Tsugane S. Changes in the Employment Status and Risk of Stroke and Stroke Types. Stroke, 48:1176-1182, 2017

13. Ugai T, Matsuo K, Sawada N, Iwasaki M, Yamaji T, Shimazu T, Sasazuki S, Inoue M, Kanda Y, Tsugane S. Coffee and Green Tea Consumption and Subsequent Risk of Malignant Lymphoma and Multiple Myeloma in Japan: The Japan Public Health Center-based Prospective Study. Cancer Epidemiol Biomarkers Prev, 26:1352-1356, 2017

14. Ugai T, Matsuo K, Sawada N, Iwasaki M, Yamaji T, Shimazu T, Sasazuki S, Inoue M, Tsugane S. Smoking and subsequent risk of leukemia in Japan: The Japan Public Health Center-based Prospective Study. J Epidemiol, 27:305-310, 2017

15. Goto A, Noda M, Goto M, Yasuda K, Mizoue T, Yamaji T, Sawada N, Iwasaki M, Inoue M, Tsugane S. Plasma adiponectin levels, ADIPOQ variants, and incidence of type 2 diabetes: A nested case-control study. Diabetes Res Clin Pract, 127:254-264, 2017

16. Masaoka H, Matsuo K, Sawada N, Yamaji T, Goto A, Shimazu T, Iwasaki M, Inoue M, Eto M, Tsugane S. Alcohol consumption and bladder cancer risk with or without the flushing response: The Japan Public Health Center-based Prospective Study. Int J Cancer, 141:2480-2488, 2017

17. Saito I, Yamagishi K, Kokubo Y, Yatsuya H, Iso H, Sawada N, Inoue M, Tsugane S. Association of high-density lipoprotein cholesterol concentration with different types of stroke and coronary heart disease: The Japan Public Health Center-based prospective (JPHC) study. Atherosclerosis, 265:147-154, 2017

18. Shitara K, Doi T, Nagano O, Imamura CK, Ozeki T, Ishii Y, Tsuchihashi K, Takahashi S, Nakajima TE, Hironaka S, Fukutani M, Hasegawa H, Nomura S, Sato A, Einaga Y, Kuwata T, Saya H, Ohtsu A. Dose-escalation study for the targeting of CD44v+ cancer stem cells by sulfasalazine in patients with advanced gastric cancer (EPOC1205). Gastric Cancer, 20:341-349, 2017

19. Takachi R, Inoue M, Sugawara Y, Tsuji I, Tsugane S, Ito H, Matsuo K, Tanaka K, Tamakoshi A, Mizoue T, Wakai K, Nagata C, Sasazuki S. Fruit and vegetable intake and the risk of overall cancer in Japanese: A pooled analysis of population-based cohort studies. J Epidemiol, 27:152-162, 2017

20. Song H, Saito E, Sawada N, Abe SK, Hidaka A, Shimazu T, Yamaji T, Goto A, Iwasaki M, Sasazuki S, Ye W, Inoue M, Tsugane S. Body mass index change during adulthood and risk of oesophageal squamous-cell carcinoma in a Japanese population: the Japan Public Health (JPHC)-based prospective study. Br J Cancer, 117:1715-1722, 2017

21. Svensson T, Inoue M, Sawada N, Charvat H, Mimura M, Tsugane S. High serum total cholesterol is associated with suicide mortality in Japanese women. Acta Psychiatr Scand, 136:259-268, 2017

22. Song H, Saito E, Sawada N, Abe SK, Hidaka A, Shimazu T, Yamaji T, Goto A, Iwasaki M, Sasazuki S, Ye W, Inoue M, Tsugane S. Perceived stress level and risk of cancer incidence in a Japanese population: the Japan Public Health Center (JPHC)-based Prospective Study. Sci Rep, 7:12964, 2017

23. Fujiwara M, Inagaki M, Nakaya N, Fujimori M, Higuchi Y, Kakeda K, Uchitomi Y, Yamada N. Association between serious psychological distress and nonparticipation in cancer screening and the modifying effect of socioeconomic status: Analysis of anonymized data from a national cross-sectional survey in Japan. Cancer, 124:555-562, 2018

24. Ugai T, Matsuo K, Sawada N, Iwasaki M, Yamaji T, Shimazu T, Goto A, Inoue M, Kanda Y, Tsugane S. Coffee and green tea consumption and subsequent risk of acute myeloid leukemia and myelodysplastic syndromes in Japan. Int J Cancer, 142:1130-1138, 2018

25. Inagaki M, Fujiwara M, Nakaya N, Fujimori M, Higuchi Y, Hayashibara C, So R, Kakeda K, Kodama M, Uchitomi Y, Yamada N. Low Cancer Screening Rates among Japanese People with Schizophrenia: A Cross-Sectional Study. Tohoku J Exp Med, 244:209-218, 2018

26. Saito E, Inoue M, Sawada N, Charvat H, Shimazu T, Yamaji T, Iwasaki M, Sasazuki S, Mizoue T, Iso H, Tsugane S. Impact of Alcohol Intake and Drinking Patterns on Mortality From All Causes and Major Causes of Death in a Japanese Population. J Epidemiol, 28:140-148, 2018

27. Ugai T, Matsuo K, Oze I, Ito H, Wakai K, Wada K, Nagata C, Nakayama T, Liu R, Kitamura Y, Tamakoshi A, Tsuji I, Sugawara Y, Sawada N, Sadakane A, Tanaka K, Mizoue T, Inoue M, Tsugane S, Shimazu T. Smoking and subsequent risk of acute myeloid leukaemia: A pooled analysis of 9 cohort studies in Japan. Hematol Oncol, 36:262-268, 2018

28. Svensson T, Inoue M, Sawada N, Mimura M, Tsugane S. High serum total cholesterol is associated with suicide mortality in Japanese women independently of menopause. Acta Psychiatr Scand, 137:80-81, 2018

29. Charvat H, Sasazuki S, Shimazu T, Budhathoki S, Inoue M, Iwasaki M, Sawada N, Yamaji T, Tsugane S. Development of a risk prediction model for lung cancer: The Japan Public Health Center-based Prospective Study. Cancer Sci, 109:854-862, 2018

30. Budhathoki S, Hidaka A, Yamaji T, Sawada N, Tanaka-Mizuno S, Kuchiba A, Charvat H, Goto A, Kojima S, Sudo N, Shimazu T, Sasazuki S, Inoue M, Tsugane S, Iwasaki M. Plasma 25-hydroxyvitamin D concentration and subsequent risk of total and site specific cancers in Japanese population: large case-cohort study within Japan Public Health Center-based Prospective Study cohort. BMJ, 360:k671, 2018