Annual Report 2018
Division of Health Care Research
Yutaka Matsuoka, Maiko Fujimori, Ryo Okubo, Ayako Sato, Akiko Hanai, Katsunori Tsuji, Saho Wada, Masako Okamura, Tempei Miyaji, Takuhiro Yamaguchi, Yoichi Shimizu, Eisuke Ochi, Saki Harashima, Hiroko Noguchi, Keisuke Inoue, Tomoe Mashiko, Masanori Mori, Ryoichi Sadahiro, Yuri Ishino, Hina Ikeda, Miyuki Kanamaru, Hiroko Takagi, Kyoko Akutsu, Sayaka Jinno, Mihoto Umehashi, Tomomi Narisawa, Naomi Inomata, Maki Minemura, Asami Satake, Kotone Hata, Kai Ueno, Miyuki Kurosaki, Asako Mitsui, Sho Murakami, Tomomi Kobayashi, Yuka Okamoto, Fumino Kobayashi
Introduction
The Division of Health Care Research was established in January 2016 by the National Cancer Center to acknowledge the numerous individuals surviving cancer for extended periods and reflecting the need to study their unmet healthcare needs. Our division works to enhance the quality and longevity of all persons diagnosed with cancer and minimize or stabilize the adverse effects experienced during their remaining lifetime. Our division supports clinical research that examines the effectiveness of supportive, palliative and psychosocial care among cancer survivors and their families.
The Team and What We Do
We have two teams, i.e. one for original research team and one for clinical research support. Our division focuses on epidemiological, interventional and behavioral and public health translational research in cancer survivorship to enhance survival and psychosocial wellbeing among all persons diagnosed with cancer and their family caregivers. Our division initiates an interdisciplinary research program ranging from basic bio-behavioral science to the development, testing and delivery of psychosocial, behavioral and survivorship care and also manages J-SUPPORT as a central support office.
Research activities
1. Health promotion research
A survey was conducted to determine the extent to which recommendations of breast cancer guidelines for physical activity are recognized and practiced by medical professionals engaged in breast cancer care. We developed high-intensity, intermittent training (habit-B) using own body weight for sedentary breast cancer survivors. The blood composition of alpha-linolenic acid and gut bacterial diversity was inversely associated with the fear of cancer recurrence, respectively in breast cancer survivors. In the meta-analysis, we also revealed that improvement in anxiety symptoms was associated with omega-3 polyunsaturated fatty acid treatment compared with controls.
2. Patient-physician communication research
We reported that as a communication method for prognostic discussion with high uncertainties, the best way to communicate news, both good and bad, is to discuss with the cancer patients clearly and optimistically, taking goals and continuity into account. We reported that patients with task-thinking coping styles required sympathetic responses. Explicit prognostic disclosure prompted better outcomes than non-disclosure in Japanese women with breast cancer. When asked about the prognosis by Asian patients with cancer, clinicians may be encouraged to respect their wishes and explicitly discuss the prognosis if deemed appropriate.
3. Suicide prevention research
To investigate the suicide risk among cancer patients in Japan and identify the patient subgroups and time periods associated with higher risk, we developed a protocol for the nationwide population-based study using data from the National Cancer Registry and developed materials to encourage mental health care access for cancer patients.
4. Developing cancer survivorship guidelines
We identified English and Japanese guidelines including cancer survivorship in their titles and proposed the need for guidelines on optimal coordination of care between oncologists and other healthcare providers to support patients along the cancer care continuum and specifically to encourage a healthy lifestyle as part of cancer survivorship. We also organized the Cancer Survivorship Guidelines General Committee and concluded an agreement on important clinical issues included in the guidelines
5. Supportive care clinical research
In consultation with medical device manufacturers regarding cooling therapy to reduce chemotherapy-induced peripheral neuropathy, work to develop a circulating cooling device got underway.
Education
Professor Jong-Heum Kim as a visiting researcher from the National Cancer Center in Korea
Future prospects
We are planning to start evaluation research with provisions to establish cancer survivorship guidelines in mind. We plan to promote behavioral research to bridge the evidencepractice gap in the field of cancer survivorship and we will continue to provide consultation on research design and statistical analysis and support clinical trials in terms of quality management.
List of papers published in 2018
Journal
1. Wada S, Sadahiro R, Matsuoka YJ, Uchitomi Y, Yamaguchi T, Shimizu K. Yokukansan for perioperative psychiatric symptoms in cancer patients undergoing high invasive surgery J-SUPPORT 1605 (ProD Study): study protocol for a randomized controlled trial. Trials, 20:110, 2019
2. Mori M, Fujimori M, Ishiki H, Nishi T, Hamano J, Otani H, Uneno Y, Oba A, Morita T, Uchitomi Y. The Effects of Adding Reassurance Statements: Cancer Patients' Preferences for Phrases in End-of- Life Discussions. J Pain Symptom Manage, 57:1121-1129, 2019
3. Mori M, Fujimori M, Ishiki H, Nishi T, Hamano J, Otani H, Uneno Y, Oba A, Morita T, Uchitomi Y. Adding a Wider Range and "Hope for the Best, and Prepare for the Worst" Statement: Preferences of Patients with Cancer for Prognostic Communication. Oncologist, 24: e943-e952 2019
4. Okubo R, Noguchi H, Hamazaki K, Sekiguchi M, Kinoshita T, Katsumata N, Narisawa T, Uezono Y, Xiao J, Matsuoka YJ. Fear of cancer recurrence among breast cancer survivors could be controlled by prudent dietary modification with polyunsaturated fatty acids. J Affect Disord, 245:1114-1118, 2019
5. Okubo R, Kinoshita T, Katsumata N, Uezono Y, Xiao J, Matsuoka YJ. Impact of chemotherapy on the association between fear of cancer recurrence and the gut microbiota in breast cancer survivors. Brain Behav Immun, 2019
6. Yoshikawa E, Nishi D, Kashimura M, Matsuoka YJ. Role of resilience for the association between trait hostility and depressive symptoms in Japanese company workers. Current Psychology, 2019
7. Barbano AC, van der Mei WF, deRoon-Cassini TA, Grauer E, Lowe SR, Matsuoka YJ, O'Donnell M, Olff M, Qi W, Ratanatharathorn A, Schnyder U, Seedat S, Kessler RC, Koenen KC, Shalev AY. Differentiating PTSD from anxiety and depression: Lessons from the ICD-11 PTSD diagnostic criteria. Depress Anxiety, 2019
8. Shalev AY, Gevonden M, Ratanatharathorn A, Laska E, van der Mei WF, Qi W, Lowe S, Lai BS, Bryant RA, Delahanty D, Matsuoka YJ, Olff M, Schnyder U, Seedat S, deRoon-Cassini TA, Kessler RC, Koenen KC. Estimating the risk of PTSD in recent trauma survivors: results of the International Consortium to Predict PTSD (ICPP). World Psychiatry, 18:77-87, 2019
9. Shibayama O, Yoshiuchi K, Inagaki M, Matsuoka Y, Yoshikawa E, Sugawara Y, Akechi T, Wada N, Imoto S, Murakami K, Ogawa A, Uchitomi Y. Long-term influence of adjuvant breast radiotherapy on cognitive function in breast cancer patients treated with conservation therapy. Int J Clin Oncol, 24:68-77, 2019
10. Barbano AC, van der Mei WF, Bryant RA, Delahanty DL, deRoon- Cassini TA, Matsuoka YJ, Olff M, Qi W, Ratanatharathorn A, Schnyder U, Seedat S, Kessler RC, Koenen KC, Shalev AY. Clinical implications of the proposed ICD-11 PTSD diagnostic criteria. Psychol Med, 49:483-490, 2019
11. Watanabe N, Horikoshi M, Shinmei I, Oe Y, Narisawa T, Kumachi M, Matsuoka Y, Hamazaki K, Furukawa TA. Brief mindfulness- based stress management program for a better mental state in working populations - Happy Nurse Project: A randomized controlled trial☆☆ . J Affect Disord, 251:186-194, 2019
12. Okubo R, Koga M, Katsumata N, Odamaki T, Matsuyama S, Oka M, Narita H, Hashimoto N, Kusumi I, Xiao J, Matsuoka YJ. Effect of bifidobacterium breve A-1 on anxiety and depressive symptoms in schizophrenia: A proof-of-concept study. J Affect Disord, 245:377-385, 2019
13. Matsumura K, Noguchi H, Rolfe P, Yamakoshi T, Matsuoka Y. Differential effect of two mental stress tasks on arterial stiffness. Japanese Psychological Research , 2019
14. Nishi D, Su KP, Usuda K, Pei-Chen Chang J, Chiang YJ, Chen HT, Chien YC, Guu TW, Okazaki E, Hamazaki K, Susukida R, Nakaya N, Sone T, Sano Y, Ito H, Isaka K, Tachibana Y, Tanigaki S, Suzuki T, Hashimoto K, Hamazaki T, Matsuoka YJ. The Efficacy of Omega-3 Fatty Acids for Depressive Symptoms among Pregnant Women in Japan and Taiwan: A Randomized, Double-Blind, Placebo-Controlled Trial (SYNCHRO; NCT01948596). Psychother Psychosom, 88:122-124, 2019
15. Nishi D, Su KP, Usuda K, Chang JP, Hamazaki K, Ishima T, Sano Y, Ito H, Isaka K, Tachibana Y, Tanigaki S, Suzuki T, Hashimoto K, Matsuoka YJ. Plasma estradiol levels and antidepressant effects of omega-3 fatty acids in pregnant women. Brain Behav Immun, 2019
16. Wu YC, Tseng PT, Tu YK, Hsu CY, Liang CS, Yeh TC, Chen TY, Chu CS, Matsuoka YJ, Stubbs B, Carvalho AF, Wada S, Lin PY, Chen YW, Su KP. The Efficacy and Safety of Pharmacological Interventions for the Management and Prevention of Delirium: a Network Meta-analysis. JAMA Psychiatry, 2019
17. Satogami K, Tseng PT, Su KP, Takahashi S, Ukai S, Li DJ, Chen TY, Lin PY, Chen YW, Matsuoka YJ. Relationship between polyunsaturated fatty acid and eating disorders: Systematic review and meta-analysis. Prostaglandins Leukot Essent Fatty Acids, 142:11-19, 2019
18. Wada S, Inoguchi H, Sadahiro R, Matsuoka YJ, Uchitomi Y, Sato T, Shimada K, Yoshimoto S, Daiko H, Shimizu K. Preoperative Anxiety as a Predictor of Delirium in Cancer Patients: A Prospective Observational Cohort Study. World J Surg, 43:134-142, 2019
19. Tagami K, Okizaki A, Miura T, Watanabe YS, Matsumoto Y, Morita T, Fujimori M, Kinoshita H. Breakthrough Cancer Pain Influences General Activities and Pain Management: A Comparison of Patients with and without Breakthrough Cancer Pain. J Palliat Med, 21:1636-1640, 2018
20. Okubo R, Noguchi H, Hamazaki K, Sekiguchi M, Kinoshita T, Katsumata N, Narisawa T, Uezono Y, Xiao J, Matsuoka YJ. Association between blood polyunsaturated fatty acid levels and depressive symptoms in breast cancer survivors. Prostaglandins Leukot Essent Fatty Acids, 139:9-13, 2018
21. Kurosawa K, Terao T, Kanehisa M, Shiotsuki I, Ishii N, Takenaka R, Sakamoto T, Matsukawa T, Yokoyama K, Ando S, Nishida A, Matsuoka Y. Naturally absorbed polyunsaturated fatty acids, lithium, and suicide-related behaviors: A case-controlled study. J Affect Disord, 241:200-205, 2018
22. Fujiwara M, Inagaki M, Nakaya N, Fujimori M, Higuchi Y, Kakeda K, Uchitomi Y, Yamada N. Smoking among adults with serious psychological distress: Analysis of anonymized data from a national cross-sectional survey in Japan. J Affect Disord, 239:131- 137, 2018
23. Yamada Y, Fujimori M, Shirai Y, Ninomiya H, Oka T, Uchitomi Y. Intrapersonal Process of Physician Empathy after a Nationwide Communication Skills Training Workshop for Oncologists in Japan. Academic Medicine, 2018
24. Qi W, Ratanatharathorn A, Gevonden M, Bryant R, Delahanty D, Matsuoka Y, Olff M, deRoon-Cassini T, Schnyder U, Seedat S, Laska E, Kessler RC, Koenen K, Shalev A on behalf of the ICPP. Application of data pooling to longitudinal studies of early post-traumatic stress disorder (PTSD): the International Consortium to Predict PTSD (ICPP) project. Eur J Psychotraumatol, 9:1476442, 2018
25. Fujiwara M, Inagaki M, Nakaya N, Fujimori M, Higuchi Y, Kakeda K, Uchitomi Y, Yamada N. Association between serious psychological distress and nonparticipation in cancer screening and the modifying effect of socioeconomic status: Analysis of anonymized data from a national cross-sectional survey in Japan. Cancer, 124:555-562, 2018
26. Inagaki M, Fujiwara M, Nakaya N, Fujimori M, Higuchi Y, Hayashibara C, So R, Kakeda K, Kodama M, Uchitomi Y, Yamada N. Low Cancer Screening Rates among Japanese People with Schizophrenia: A Cross-Sectional Study. Tohoku J Exp Med, 244:209-218, 2018
27. Watanabe N, Matsuoka Y, Kumachi M, Hamazaki K, Horikoshi M, Furukawa TA. Omega-3 fatty acids for a better mental state in working populations - Happy Nurse Project: A 52-week randomized controlled trial. J Psychiatr Res, 102:72-80, 2018
28. Okubo R, Chen C, Sekiguchi M, Hamazaki K, Matsuoka YJ. Mechanisms underlying the effects of n-3 polyunsaturated fatty acids on fear memory processing and their hypothetical effects on fear of cancer recurrence in cancer survivors. Prostaglandins Leukot Essent Fatty Acids, 131:14-23, 2018
29. Zenda S, Yamaguchi T, Yokota T, Miyaji T, Mashiko T, Tanaka M, Yonemura M, Takeno M, Okano T, Kawasaki T, Nakamori Y, Ishii S, Shimada S, Kanamaru M, Uchitomi Y. Topical steroid versus placebo for the prevention of radiation dermatitis in head and neck cancer patients receiving chemoradiotherapy: the study protocol of J-SUPPORT 1602 (TOPICS study), a randomized double-blinded phase 3 trial. BMC Cancer, 18:873, 2018
30. Su KP, Tseng PT, Lin PY, Okubo R, Chen TY, Chen YW, Matsuoka YJ. Association of Use of Omega-3 Polyunsaturated Fatty Acids With Changes in Severity of Anxiety Symptoms: A Systematic Review and Meta-analysis. JAMA Network Open, 1:e182327, 2018