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Annual Report 2019

Division of Cohort Consortium Research

Shoichiro Tsugane, Manami Inoue, Motoki Iwasaki, Maiko Fujimori, Jun Umezawa, Osamu Hemmi, Hikaru Ihira, Takuya Imato, Takahiro Mita, Ayako Toyama

Introduction

 The Division of Cohort Consortium Research aims to create evidence for the prevention of cancer and other diseases and extend the healthy life expectancy of Japanese. It does this by conducting epidemiological research using a domestic epidemiological research network.

Research activities

1. The Collaborative Epidemiological Research Network Project of the Six National Centers for Advanced and Specialized Medical Care (6NC Project).

 The 6NC Project is a core research project of the Division of Cohort Consortium Research. The main aim of the 6NC Project is to establish the 6NC Epidemiological Research Collaboration Platform, which will be used to conduct pooled analyses and mutual data analysis by exchange and cooperation among researchers at the six national centers. As part of this project we have established an analysis platform which offers both onsite and remote access with information security protection. We have also launched an initiative working group to make recommendations to extend the healthy life expectancy of Japanese, and for comprehensive disease prevention. This project started in 2017.

2. Promotion of collaborative research among six NCs using ongoing cohort studies in the NCC

 Using data from the JPHC Study, we proposed one research protocol on depression in collaboration with the National Center of Neurology and Psychiatry and two research protocols on dementia assessed by the long-term care insurance system in collaboration with the National Center for Geriatrics and Gerontology, the latter commencing analysis after IRB approval. Regarding collaborative studies using data from the JPHC-NEXT study, we have four ongoing studies proposed by the National Center of Neurology and Psychiatry and National Center for Child Health and Development, respectively, and we have analyzed data after obtaining IRB approval.

 Regarding practical use of electronic medical information in cohort studies, we have collected information on health insurance claims and diagnosis procedure combinations (DPC) in the JPHC-NEXT study and conducted a validation study for diagnosis of cancer and diabetes using this information.

Future prospects

 As well as creating scientific evidence, we will expand and strengthen research collaboration networks aiming to extend the healthy life expectancy of Japanese, and promote comprehensive interdisciplinary disease prevention.

List of papers published in 2019

Journal

1. Okubo R, Matsuoka YJ, Sawada N, Mimura M, Kurotani K, Nozaki S, Shikimoto R, Tsugane S. Diet quality and depression risk in a Japanese population: the Japan Public Health Center (JPHC)-based Prospective Study. Sci Rep, 9:7150, 2019

2. Sadahiro R, Sawada N, Matsuoka YJ, Mimura M, Nozaki S, Shikimoto R, Goto A, Tsugane S. Midlife cancer/diabetes and risk of dementia and mild cognitive impairment: A population-based prospective cohort study in Japan. Psychiatry Clin Neurosci, 73:597-599, 2019

3. Okubo R, Wada S, Shimizu Y, Tsuji K, Hanai A, Imai K, Uchitomi Y, Fujiwara Y, Tsugane S, Matsuoka YJ. Expectations of and recommendations for a cancer survivorship guideline in Japan: a literature review of guidelines for cancer survivorship. Jpn J Clin Oncol, 49:812-822, 2019

4. Camargo MC, Song M, Shimazu T, Charvat H, Yamaji T, Sawada N, Kemp TJ, Pfeiffer RM, Hildesheim A, Pinto LA, Tsugane S, Rabkin CS. Circulating Inflammation Markers and Risk of Gastric and Esophageal Cancers: A Case-Cohort Study Within the Japan Public Health Center-Based Prospective Study. Cancer Epidemiol Biomarkers Prev, 28:829-832, 2019

5. Hayashi R, Iso H, Yamagishi K, Yatsuya H, Saito I, Kokubo Y, Eshak ES, Sawada N, Tsugane S. Working Hours and Risk of Acute Myocardial Infarction and Stroke Among Middle-Aged Japanese Men - The Japan Public Health Center-Based Prospective Study Cohort II. Circ J, 83:1072-1079, 2019

6. Hirabayashi M, Inoue M, Sawada N, Saito E, Abe SK, Hidaka A, Iwasaki M, Yamaji T, Shimazu T, Tsugane S. Helicobacter pylori infection, atrophic gastritis, and risk of pancreatic cancer: A population-based cohort study in a large Japanese population: the JPHC Study. Sci Rep, 9:6099, 2019

7. Mori N, Shimazu T, Charvat H, Mutoh M, Sawada N, Iwasaki M, Yamaji T, Inoue M, Goto A, Takachi R, Ishihara J, Noda M, Iso H, Tsugane S. Cruciferous vegetable intake and mortality in middle-aged adults: A prospective cohort study. Clin Nutr, 38:631-643, 2019

8. Tanaka S, Sawada N, Yamaji T, Shimazu T, Goto A, Iwasaki M, Inoue M, Tsugane S. Female reproductive factors and risk of lymphoid neoplasm: The Japan Public Health Center-based Prospective Study. Cancer Sci, 110:1442-1452, 2019

9. Viet Vu CH, Uchino M, Kawashima M, Yuki K, Tsubota K, Nishi A, German CA, Sakata K, Tanno K, Iso H, Yamagishi K, Yasuda N, Saito I, Kato T, Arima K, Tomita Y, Shimazu T, Yamaji T, Goto A, Inoue M, Iwasaki M, Sawada N, Tsugane S. Lack of social support and social trust as potential risk factors for dry eye disease: JPHC-NEXT study. Ocul Surf, 17:278-284, 2019

10. Yamagiwa Y, Sawada N, Shimazu T, Yamaji T, Goto A, Takachi R, Ishihara J, Iwasaki M, Inoue M, Tsugane S. Fruit and vegetable intake and pancreatic cancer risk in a population-based cohort study in Japan. Int J Cancer, 144:1858-1866, 2019

11. Yang JJ, Yu D, Wen W, Saito E, Rahman S, Shu XO, Chen Y, Gupta PC, Gu D, Tsugane S, Xiang YB, Gao YT, Yuan JM, Tamakoshi A, Irie F, Sadakane A, Tomata Y, Kanemura S, Tsuji I, Matsuo K, Nagata C, Chen CJ, Koh WP, Shin MH, Park SK, Wu PE, Qiao YL, Pednekar MS, He J, Sawada N, Li HL, Gao J, Cai H, Wang R, Sairenchi T, Grant E, Sugawara Y, Zhang S, Ito H, Wada K, Shen CY, Pan WH, Ahn YO, You SL, Fan JH, Yoo KY, Ashan H, Chia KS, Boffetta P, Inoue M, Kang D, Potter JD, Zheng W. Association of Diabetes With All-Cause and Cause-Specific Mortality in Asia: A Pooled Analysis of More Than 1 Million Participants. JAMA Netw Open, 2:e192696, 2019

12. Ferro A, Morais S, Pelucchi C, Dierssen-Sotos T, Martín V, López-Carrillo L, Malekzadeh R, Tsugane S, Hamada GS, Hidaka A, Hernández-Ramírez RU, López-Cervantes M, Zaridze D, Maximovitch D, Pourfarzi F, Zhang ZF, Yu GP, Pakseresht M, Ye W, Plymoth A, Leja M, Gasenko E, Derakhshan MH, Negri E, La Vecchia C, Peleteiro B, Lunet N. Sex differences in the prevalence of Helicobacter pylori infection: an individual participant data pooled analysis (StoP Project). Eur J Gastroenterol Hepatol, 31:593-598, 2019

13. Kabasawa K, Hosojima M, Takachi R, Nakamura K, Ito Y, Saito A, Sawada N, Tsugane S, Tanaka J, Narita I. Association of estimated dietary acid load with albuminuria in Japanese adults: a cross-sectional study. BMC Nephrol, 20:194, 2019

14. Kawachi A, Shimazu T, Budhathoki S, Sawada N, Yamaji T, Iwasaki M, Inoue M, Tsugane S. Association of BMI and height with the risk of endometrial cancer, overall and by histological subtype: a population-based prospective cohort study in Japan. Eur J Cancer Prev, 28:196-202, 2019

15. Makiuchi T, Sobue T, Kitamura T, Sawada N, Iwasaki M, Yamaji T, Shimazu T, Inoue M, Tsugane S. Smoking, Alcohol Consumption, and Risks for Biliary Tract Cancer and Intrahepatic Bile Duct Cancer. J Epidemiol, 29:180-186, 2019

16. Tanikawa C, Kamatani Y, Terao C, Usami M, Takahashi A, Momozawa Y, Suzuki K, Ogishima S, Shimizu A, Satoh M, Matsuo K, Mikami H, Naito M, Wakai K, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Kohri K, Yu ASL, Yasui T, Murakami Y, Kubo M, Matsuda K. Novel Risk Loci Identified in a Genome-Wide Association Study of Urolithiasis in a Japanese Population. J Am Soc Nephrol, 30:855-864, 2019

17. Abe SK, Saito E, Sawada N, Tsugane S, Ito H, Lin Y, Tamakoshi A, Sado J, Kitamura Y, Sugawara Y, Tsuji I, Nagata C, Sadakane A, Shimazu T, Mizoue T, Matsuo K, Naito M, Tanaka K, Inoue M. Coffee consumption and mortality in Japanese men and women: A pooled analysis of eight population-based cohort studies in Japan (Japan Cohort Consortium). Prev Med, 123:270-277, 2019

18. Bertuccio P, Alicandro G, Rota M, Pelucchi C, Bonzi R, Galeone C, Bravi F, Johnson KC, Hu J, Palli D, Ferraroni M, López-Carrillo L, Lunet N, Ferro A, Malekzadeh R, Zaridze D, Maximovitch D, Vioque J, Navarrete-Munoz EM, Pakseresht M, Hernández-Ramírez RU, López-Cervantes M, Ward M, Pourfarzi F, Tsugane S, Hidaka A, Zhang ZF, Kurtz RC, Lagiou P, Lagiou A, Boffetta P, Boccia S, Negri E, La Vecchia C. Citrus fruit intake and gastric cancer: The stomach cancer pooling (StoP) project consortium. Int J Cancer, 144:2936-2944, 2019

19. Maruyama K, Ikeda A, Ishihara J, Takachi R, Sawada N, Shimazu T, Nakamura K, Tanaka J, Yamaji T, Iwasaki M, Iso H, Tsugane S. Food frequency questionnaire reproducibility for middle-aged and elderly Japanese. Asia Pac J Clin Nutr, 28:362-370, 2019

20. Nishiyama T, Nakatochi M, Goto A, Iwasaki M, Hachiya T, Sutoh Y, Shimizu A, Wang C, Tanaka H, Watanabe M, Hosono A, Tamai Y, Yamada T, Yamaji T, Sawada N, Fukumoto K, Otsuka K, Tanno K, Tomita H, Kojima K, Nagasaki M, Hozawa A, Hishida A, Sasakabe T, Nishida Y, Hara M, Ito H, Oze I, Nakamura Y, Mikami H, Ibusuki R, Takezaki T, Koyama T, Kuriyama N, Endoh K, Kuriki K, Turin TC, Naoyuki T, Katsuura-Kamano S, Uemura H, Okada R, Kawai S, Naito M, Momozawa Y, Kubo M, Sasaki M, Yamamoto M, Tsugane S, Wakai K, Suzuki S. Genome-wide association meta-analysis and Mendelian randomization analysis confirm the influence of ALDH2 on sleep durationin the Japanese population. Sleep, 42:zsz046, 2019

21. Ugai T, Milne RL, Ito H, Aronson KJ, Bolla MK, Chan T, Chan CW, Choi JY, Conroy DM, Dennis J, Dunning AM, Easton DF, Gaborieau V, Gonzalez-Neira A, Hartman M, Healey CS, Iwasaki M, John EM, Kang D, Kim SW, Kwong A, Lophatananon A, Michailidou K, Taib NAM, Muir K, Park SK, Pharoah PDP, Sangrajrang S, Shen CY, Shu XO, Spinelli JJ, Teo SH, Tessier DC, Tseng CC, Tsugane S, Vincent D, Wang Q, Wu AH, Wu PE, Zheng W, Matsuo K. The functional ALDH2 polymorphism is associated with breast cancer risk: A pooled analysis from the Breast Cancer Association Consortium. Mol Genet Genomic Med, 7:e707, 2019

22. Dörk T, Peterlongo P, Mannermaa A, Bolla MK, Wang Q, Dennis J, Ahearn T, Andrulis IL, Anton-Culver H, Arndt V, Aronson KJ, Augustinsson A, Freeman LEB, Beckmann MW, Beeghly-Fadiel A, Behrens S, Bermisheva M, Blomqvist C, Bogdanova NV, Bojesen SE, Brauch H, Brenner H, Burwinkel B, Canzian F, Chan TL, Chang-Claude J, Chanock SJ, Choi JY, Christiansen H, Clarke CL, Couch FJ, Czene K, Daly MB, Dos-Santos-Silva I, Dwek M, Eccles DM, Ekici AB, Eriksson M, Evans DG, Fasching PA, Figueroa J, Flyger H, Fritschi L, Gabrielson M, Gago-Dominguez M, Gao C, Gapstur SM, García-Closas M, García-Sáenz JA, Gaudet MM, Giles GG, Goldberg MS, Goldgar DE, Guénel P, Haeberle L, Haiman CA, Håkansson N, Hall P, Hamann U, Hartman M, Hauke J, Hein A, Hillemanns P, Hogervorst FBL, Hooning MJ, Hopper JL, Howell T, Huo D, Ito H, Iwasaki M, Jakubowska A, Janni W, John EM, Jung A, Kaaks R, Kang D, Kapoor PM, Khusnutdinova E, Kim SW, Kitahara CM, Koutros S, Kraft P, Kristensen VN, Kwong A, Lambrechts D, Marchand LL, Li J, Lindström S, Linet M, Lo WY, Long J, Lophatananon A, Lubiński J, Manoochehri M, Manoukian S, Margolin S, Martinez E, Matsuo K, Mavroudis D, Meindl A, Menon U, Milne RL, Mohd Taib NA, Muir K, Mulligan AM, Neuhausen SL, Nevanlinna H, Neven P, Newman WG, Offit K, Olopade OI, Olshan AF, Olson JE, Olsson H, Park SK, Park-Simon TW, Peto J, Plaseska-Karanfilska D, Pohl-Rescigno E, Presneau N, Rack B, Radice P, Rashid MU, Rennert G, Rennert HS, Romero A, Ruebner M, Saloustros E, Schmidt MK, Schmutzler RK, Schneider MO, Schoemaker MJ, Scott C, Shen CY, Shu XO, Simard J, Slager S, Smichkoska S, Southey MC, Spinelli JJ, Stone J, Surowy H, Swerdlow AJ, Tamimi RM, Tapper WJ, Teo SH, Terry MB, Toland AE, Tollenaar RAEM, Torres D, Torres-Mejía G, Troester MA, Truong T, Tsugane S, Untch M, Vachon CM, Ouweland AMWVD, Veen EMV, Vijai J, Wendt C, Wolk A, Yu JC, Zheng W, Ziogas A, Ziv E, Dunning AM, Pharoah PDP, Schindler D, Devilee P, Easton DF. Two truncating variants in FANCC and breast cancer risk. Sci Rep, 9:12524, 2019

23. Jackson SS, Van Dyke AL, Zhu B, Pfeiffer RM, Petrick JL, Adami HO, Albanes D, Andreotti G, Beane Freeman LE, Berrington de González A, Buring JE, Chan AT, Chen Y, Fraser GE, Freedman ND, Gao YT, Gapstur SM, Gaziano JM, Giles GG, Grant EJ, Grodstein F, Hartge P, Jenab M, Kitahara CM, Knutsen SF, Koh WP, Larsson SC, Lee IM, Liao LM, Luo J, McGee EE, Milne RL, Monroe KR, Neuhouser ML, O'Brien KM, Peters U, Poynter JN, Purdue MP, Robien K, Sandler DP, Sawada N, Schairer C, Sesso HD, Simon TG, Sinha R, Stolzenberg-Solomon RZ, Tsugane S, Wang R, Weiderpass E, Weinstein SJ, White E, Wolk A, Yuan JM, Zeleniuch-Jacquotte A, Zhang X, McGlynn KA, Campbell PT, Koshiol J. Anthropometric Risk Factors for Cancers of the Biliary Tract in the Biliary Tract Cancers Pooling Project. Cancer Res, 79:3973-3982, 2019

24. Koyanagi YN, Ito H, Matsuo K, Sugawara Y, Hidaka A, Sawada N, Wada K, Nagata C, Tamakoshi A, Lin Y, Takeuchi T, Kitamura Y, Utada M, Sadakane A, Mizoue T, Naito M, Tanaka K, Shimazu T, Tsugane S, Inoue M. Smoking and Pancreatic Cancer Incidence: A Pooled Analysis of 10 Population-Based Cohort Studies in Japan. Cancer Epidemiol Biomarkers Prev, 28:1370-1378, 2019

25. Yamagishi K, Iso H, Shimazu T, Tamakoshi A, Sawada N, Matsuo K, Ito H, Wakai K, Nakayama T, Kitamura Y, Sado J, Tsuji I, Sugawara Y, Mizoue T, Inoue M, Nagata C, Sadakane A, Tanaka K, Tsugane S, Sasazuki S. Fish intake and risk of mortality due to aortic dissection and aneurysm: A pooled analysis of the Japan cohort consortium. Clin Nutr, 38:1678-1683, 2019

26. Yang K, Zhang Y, Saito E, Rahman MS, Gupta PC, Sawada N, Tamakoshi A, Gao YT, Koh WP, Shu XO, Tsuji I, Sadakane A, Nagata C, You SL, Yuan JM, Shin MH, Chen Y, Pan WH, Pednekar MS, Tsugane S, Cai H, Xiang YB, Ozasa K, Tomata Y, Kanemura S, Sugawara Y, Wada K, Wang R, Ahn YO, Yoo KY, Ahsan H, Chia KS, Boffetta P, Kang D, Potter JD, Inoue M, Zheng W, Nan H. Association between educational level and total and cause-specific mortality: a pooled analysis of over 694 000 individuals in the Asia Cohort Consortium. BMJ Open, 9:e026225, 2019

27. Yuwaki K, Shimazu T, Yamagiwa Y, Inoue M, Goto A, Yamaji T, Iwasaki M, Sawada N, Tsugane S. Association between serum liver enzymes and all-cause mortality: The Japan Public Health Center-based Prospective Study. Liver Int, 39:1566-1576, 2019

28. Akiyama M, Ishigaki K, Sakaue S, Momozawa Y, Horikoshi M, Hirata M, Matsuda K, Ikegawa S, Takahashi A, Kanai M, Suzuki S, Matsui D, Naito M, Yamaji T, Iwasaki M, Sawada N, Tanno K, Sasaki M, Hozawa A, Minegishi N, Wakai K, Tsugane S, Shimizu A, Yamamoto M, Okada Y, Murakami Y, Kubo M, Kamatani Y. Characterizing rare and low-frequency height-associated variants in the Japanese population. Nat Commun, 10:4393, 2019

29. Ferro A, Morais S, Pelucchi C, Aragonés N, Kogevinas M, López-Carrillo L, Malekzadeh R, Tsugane S, Hamada GS, Hidaka A, Hernández-Ramírez RU, López-Cervantes M, Zaridze D, Maximovitch D, Pourfarzi F, Zhang ZF, Yu GP, Pakseresht M, Ye W, Plymoth A, Leja M, Gasenko E, Derakhshan MH, Negri E, La Vecchia C, Peleteiro B, Lunet N. Smoking and Helicobacter pylori infection: an individual participant pooled analysis (Stomach Cancer Pooling- StoP Project). Eur J Cancer Prev, 28:390-396, 2019

30. Kurotani K, Honjo K, Nakaya T, Ikeda A, Mizoue T, Sawada N, Tsugane S. Diet Quality Affects the Association between Census-Based Neighborhood Deprivation and All-Cause Mortality in Japanese Men and Women: The Japan Public Health Center-Based Prospective Study. Nutrients, 11:2194, 2019

31. Li Y, Yatsuya H, Iso H, Yamagishi K, Saito I, Kokubo Y, Sawada N, Tsugane S. Body Mass Index and Risks of Incident Ischemic Stroke Subtypes: The Japan Public Health Center-Based Prospective (JPHC) Study. J Epidemiol, 29:325-333, 2019

32. Liu R, Sobue T, Kitamura T, Kitamura Y, Ishihara J, Kotemori A, Zha L, Ikeda S, Sawada N, Iwasaki M, Tsugane S. Dietary Acrylamide Intake and Risk of Esophageal, Gastric, and Colorectal Cancer: The Japan Public Health Center-Based Prospective Study. Cancer Epidemiol Biomarkers Prev, 28:1461-1468, 2019

33. Mori N, Sawada N, Iwasaki M, Yamaji T, Goto A, Shimazu T, Inoue M, Murphy N, Gunter MJ, Tsugane S. Circulating sex hormone levels and colorectal cancer risk in Japanese postmenopausal women: The JPHC nested case-control study. Int J Cancer, 145:1238-1244, 2019

34. Mori N, Sawada N, Shimazu T, Yamaji T, Goto A, Takachi R, Ishihara J, Iwasaki M, Inoue M, Tsugane S. Cruciferous vegetable intake and colorectal cancer risk: Japan public health center-based prospective study. Eur J Cancer Prev, 28:420-427, 2019

35. Takata R, Takahashi A, Fujita M, Momozawa Y, Saunders EJ, Yamada H, Maejima K, Nakano K, Nishida Y, Hishida A, Matsuo K, Wakai K, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Sasaki M, Shimizu A, Tanno K, Minegishi N, Suzuki K, Matsuda K, Kubo M, Inazawa J, Egawa S, Haiman CA, Ogawa O, Obara W, Kamatani Y, Akamatsu S, Nakagawa H. 12 new susceptibility loci for prostate cancer identified by genome-wide association study in Japanese population. Nat Commun, 10:4422, 2019

36. Abe SK, Saito E, Sawada N, Tsugane S, Ito H, Lin Y, Tamakoshi A, Sado J, Kitamura Y, Sugawara Y, Tsuji I, Nagata C, Sadakane A, Shimazu T, Mizoue T, Matsuo K, Naito M, Tanaka K, Inoue M. Green tea consumption and mortality in Japanese men and women: a pooled analysis of eight population-based cohort studies in Japan. Eur J Epidemiol, 34:917-926, 2019

37. Butt J, Varga MG, Wang T, Tsugane S, Shimazu T, Zheng W, Abnet CC, Yoo KY, Park SK, Kim J, Jee SH, Qiao YL, Shu XO, Waterboer T, Pawlita M, Epplein M. Smoking, Helicobacter Pylori Serology, and Gastric Cancer Risk in Prospective Studies from China, Japan, and Korea. Cancer Prev Res (Phila), 12:667-674, 2019

38. Kashino I, Serafini M, Kurotani K, Akter S, Mizoue T, Ishihara J, Kotemori A, Sawada N, Inoue M, Iwasaki M, Noda M, Tsugane S. Relationship between dietary non-enzymatic antioxidant capacity and type 2 diabetes risk in the Japan Public Health Center-based Prospective Study. Nutrition, 66:62-69, 2019

39. Mori K, Kurihara T, Uchino M, Torii H, Kawashima M, Sasaki M, Ozawa Y, Yamagishi K, Iso H, Sawada N, Tsugane S, Yuki K, Tsubota K. High Myopia and Its Associated Factors in JPHC-NEXT Eye Study: A Cross-Sectional Observational Study. J Clin Med, 8:1788, 2019

40. Oze I, Charvat H, Matsuo K, Ito H, Tamakoshi A, Nagata C, Wada K, Sugawara Y, Sawada N, Yamaji T, Naito M, Tanaka K, Shimazu T, Mizoue T, Tsugane S, Inoue M. Revisit of an unanswered question by pooled analysis of eight cohort studies in Japan: Does cigarette smoking and alcohol drinking have interaction for the risk of esophageal cancer? Cancer Med, 8:6414-6425, 2019

41. Shimizu Y, Sawada N, Iwasaki M, Shikimoto R, Nozaki S, Mimura M, Tsugane S. Reproductive history and risk of cognitive impairment in Japanese women. Maturitas, 128:22-28, 2019

42. Takiguchi R, Komatsu R, Kitamura K, Watanabe Y, Takahashi A, Kobayashi R, Oshiki R, Saito T, Kabasawa K, Takachi R, Tsugane S, Iki M, Sasaki A, Yamazaki O, Nakamura K. Modifiable factors associated with symptomatic knee osteoarthritis: The Murakami cohort study. Maturitas, 128:53-59, 2019

43. Tanaka K, Tamakoshi A, Sugawara Y, Mizoue T, Inoue M, Sawada N, Matsuo K, Ito H, Naito M, Nagata C, Kitamura Y, Sadakane A, Tsugane S, Shimazu T. Coffee, green tea and liver cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population. Jpn J Clin Oncol, 49:972-984, 2019

44. Tanaka S, Abe SK, Sawada N, Yamaji T, Shimazu T, Goto A, Iwasaki M, Iso H, Mizoue T, Inoue M, Tsugane S. Female reproductive factors and risk of external causes of death among women: The Japan Public Health Center-based Prospective Study (JPHC Study). Sci Rep, 9:14329, 2019

45. Budhathoki S, Sawada N, Iwasaki M, Yamaji T, Goto A, Kotemori A, Ishihara J, Takachi R, Charvat H, Mizoue T, Iso H, Tsugane S. Association of Animal and Plant Protein Intake With All-Cause and Cause-Specific Mortality in a Japanese Cohort. JAMA Intern Med, 179:1509-1518, 2019

46. Islam Z, Akter S, Kashino I, Mizoue T, Sawada N, Mori N, Yamagiwa Y, Tsugane S, Naito M, Tamakoshi A, Wada K, Nagata C, Sugawara Y, Tsuji I, Matsuo K, Ito H, Lin Y, Kitamura Y, Sadakane A, Tanaka K, Shimazu T, Inoue M. Meat subtypes and colorectal cancer risk: A pooled analysis of 6 cohort studies in Japan. Cancer Sci, 110:3603-3614, 2019

47. Kashino I, Mizoue T, Serafini M, Akter S, Sawada N, Ishihara J, Kotemori A, Inoue M, Yamaji T, Goto A, Iwasaki M, Noda M, Tsugane S. Higher Dietary Non-enzymatic Antioxidant Capacity Is Associated with Decreased Risk of All-Cause and Cardiovascular Disease Mortality in Japanese Adults. J Nutr, 149:1967-1976, 2019

48. Low SK, Chin YM, Ito H, Matsuo K, Tanikawa C, Matsuda K, Saito H, Sakurai-Yageta M, Nakaya N, Shimizu A, Nishizuka SS, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Takezaki T, Suzuki S, Naito M, Wakai K, Kamatani Y, Momozawa Y, Murakami Y, Inazawa J, Nakamura Y, Kubo M, Katagiri T, Miki Y. Identification of two novel breast cancer loci through large-scale genome-wide association study in the Japanese population. Sci Rep, 9:17332, 2019

49. Ugai T, Ito H, Oze I, Saito E, Rahman MS, Boffetta P, Gupta PC, Sawada N, Tamakoshi A, Shu XO, Koh WP, Gao YT, Sadakane A, Tsuji I, Park SK, Nagata C, You SL, Pednekar MS, Tsugane S, Cai H, Yuan JM, Xiang YB, Ozasa K, Tomata Y, Kanemura S, Sugawara Y, Wada K, Chen CJ, Yoo KY, Chia KS, Ahsan H, Zheng W, Inoue M, Kang D, Potter J, Matsuo K. Association of BMI, Smoking, and Alcohol with Multiple Myeloma Mortality in Asians: A Pooled Analysis of More than 800,000 Participants in the Asia Cohort Consortium. Cancer Epidemiol Biomarkers Prev, 28:1861-1867, 2019

50. Hirabayashi M, Inoue M, Sawada N, Saito E, Abe SK, Hidaka A, Iwasaki M, Yamaji T, Shimazu T, Shibuya K, Tsugane S. Effect of body-mass index on the risk of gastric cancer: A population-based cohort study in A Japanese population. Cancer Epidemiol, 63:101622, 2019

51. McGee EE, Jackson SS, Petrick JL, Van Dyke AL, Adami HO, Albanes D, Andreotti G, Beane-Freeman LE, Berrington de Gonzalez A, Buring JE, Chan AT, Chen Y, Fraser GE, Freedman ND, Gao YT, Gapstur SM, Gaziano JM, Giles GG, Grant EJ, Grodstein F, Hartge P, Jenab M, Kitahara CM, Knutsen SF, Koh WP, Larsson SC, Lee IM, Liao LM, Luo J, Milne RL, Monroe KR, Neuhouser ML, O'Brien KM, Peters U, Poynter JN, Purdue MP, Robien K, Sandler DP, Sawada N, Schairer C, Sesso HD, Simon TG, Sinha R, Stolzenberg-Solomon R, Tsugane S, Wang R, Weiderpass E, Weinstein SJ, White E, Wolk A, Yuan JM, Zeleniuch-Jacquotte A, Zhang X, Zhu B, McGlynn KA, Campbell PT, Koshiol J. Smoking, Alcohol, and Biliary Tract Cancer Risk: A Pooling Project of 26 Prospective Studies. J Natl Cancer Inst, 111:1263-1278, 2019

52. Murai U, Yamagishi K, Sata M, Kokubo Y, Saito I, Yatsuya H, Ishihara J, Inoue M, Sawada N, Iso H, Tsugane S. Seaweed intake and risk of cardiovascular disease: the Japan Public Health Center-based Prospective (JPHC) Study. Am J Clin Nutr, 110:1449-1455, 2019

53. Honjo K, Iso H, Ikeda A, Yamagishi K, Saito I, Kato T, Yasuda N, Aoyagi K, Arima K, Sakata K, Tanno K, Inoue M, Iwasaki M, Shimazu T, Goto A, Yamaji T, Sawada N, Tsugane S. Cross-sectional association between employment status and self-rated health among middle-aged Japanese women: The influence of socioeconomic conditions and work-life conflict. J Epidemiol, 2019

54. Adachi S, Sawada N, Yuki K, Uchino M, Iwasaki M, Tsubota K, Tsugane S. Intake of vegetables and fruits and the risk of cataract incidence in a Japanese population: the Japan Public Health Center-based Prospective Study. J Epidemiol, 2019

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