Annual Report 2020
Division of Science and Technology for Endoscopy (Kashiwa Campus)
Hiroaki Ikematsu, Tomonori Yano, Tatsuro Murano, Keiichiro Nakajo, Toshihiro Takamatsu, Takako Mamada, Eri Oishibashi
Introduction
The progress of endoscopic diagnosis and treatment equipment is remarkable. However, there are certain devices that have yet to be expected, such as cancer screening equipment, diagnostic equipment that are sometimes overlooked, diagnostic equipment for deep lesions, and devices for treatment complications. We are therefore conducting basic research by incorporating the seeds of science and engineering academia into developing these devices.
Research activities
The equipment development in 2020 was as follows: (1) Research targeting submucosal tumors and gastric cancer by irradiating with near-infrared light in the wavelength range of 1,000 nm or more, as well as the development of a flexible endoscope for this purpose, (2) Basic experiments in the gastrointestinal tract using photoacoustic images, which are expected to be effective in the deep vascular diagnosis of lesions, (3) Development of endoscopic diagnostic aids using artificial intelligence, (4) Development of automatic colon insertion endoscopes, (5) Development of hemostatic devices for endoscopes using plasma, (6) Molecular biological analysis of early gastrointestinal cancer, which is the basis for non-invasive diagnostic methods, and (7) Development of mass analysis technology for deep tissues. All of these are highly-novel seeds and systems that have never existed before, and can be expected to be clinically useful. Regarding (1), we calculated the wavelength particular to GIST and applied for a patent.
Clinical trials
1) Development of diagnostic endoscopy for GIST and gastric cancer using near-infrared light
2) Photoacoustic imaging of fresh human surgical and endoscopic gastrointestinal specimens: a pilot study
Education
One researcher at Tokyo University of Science was sent to our hospital (National Cancer Center Hospital East: NCCHE) by a cross-appointment with Tokyo University of Science. Meetings are constantly conducted with faculties including technology and science students from Tokyo University of Science.
Future Prospects
In the future, we will continue to develop endoscopic equipment in cooperation with the Department of Gastroenterology and Endoscopy of the NCCHE and attempt innovative approaches to produce all-new endoscopy approaches/devices in collaboration with academia and corporations. With the aim of acquiring new seeds, we are developing the research infrastructure necessary to collaborate with academia.
List of papers published in 2020
Journal
1. Ito R, Ikematsu H, Murano T, Shinmura K, Kojima M, Kumahara K, Furue Y, Sunakawa H, Minamide T, Sato D, Yamamoto Y, Takashima K, Yoda Y, Hori K, Yano T. Diagnostic ability of Japan Narrow-Band Imaging Expert Team classification for colorectal lesions by magnifying endoscopy with blue laser imaging versus narrow-band imaging. Endosc Int Open, 9:E271-E277, 2021
2. Sunakawa H, Hori K, Kadota T, Shinmura K, Yoda Y, Ikematsu H, Tomioka T, Akimoto T, Hayashi R, Fujii S, Yano T. Relationship between the microvascular patterns observed by magnifying endoscopy with narrow-band imaging and the depth of invasion in superficial pharyngeal squamous cell carcinoma. Esophagus, 18:111-117, 2021
3. Nakajo K, Yoda Y, Kadota T, Murano T, Shinmura K, Ikematsu H, Akimoto T, Yano T. Radial incision and cutting for dilation before endoscopic submucosal dissection in patients with esophageal cancer on the distal side of severe benign esophageal strictures. Dis Esophagus, 34:2021
4. Minamide T, Ikematsu H, Murano T, Kadota T, Shinmura K, Yoda Y, Hori K, Ito M, Yano T. Metachronous advanced neoplasia after submucosal invasive colorectal cancer resection. Sci Rep, 11:1869, 2021
5. Nishihara K, Hori K, Saito T, Omori T, Sunakawa H, Minamide T, Suyama M, Yamamoto Y, Yoda Y, Shinmura K, Ikematsu H, Yano T. A study of evaluating specific tissue oxygen saturation values of gastrointestinal tumors by removing adherent substances in oxygen saturation imaging. PLoS One, 16:e0243165, 2021
6. Nakajima T, Sakamoto T, Hori S, Yamada S, Ikematsu H, Harada K, Chiu HM, Kiriyama S, Michida T, Hotta K, Sakamoto N, Abe T, Chino A, Fukuzawa M, Kobayashi N, Fukase K, Matsuda T, Murakami Y, Ishikawa H, Saito Y. Optimal surveillance interval after piecemeal endoscopic mucosal resection for large colorectal neoplasia: a multicenter randomized controlled trial. Surg Endosc, 2021
7. Noguchi M, Shitara K, Kawazoe A, Yamamoto D, Takii Y, Saito Y, Sato T, Horimatsu T, Ishikawa H, Ito Y, Ito M, Ikematsu H. Short-term safety of adjuvant chemoradiotherapy after local resection for patients with high-risk submucosal invasive rectal cancer: a single-arm, multicenter phase II trial. Jpn J Clin Oncol, 51:707-712, 2021
8. Ito R, Kadota T, Murano T, Yoda Y, Hori K, Minamide T, Sato D, Yamamoto Y, Takashima K, Shinmura K, Ikematsu H, Yano T. Clinical features and risk factors of gastric cancer detected by esophagogastroduodenoscopy in esophageal cancer patients. Esophagus, 18:621-628, 2021
9. Akimoto K, Ike R,Maeda K, Hosokawa N, Takamatsu T, Soga K, Yokota H, Sato D, Kuwata T, Ikematsu H, Takemura H. Wavelength Bands Reduction Method in Near-Infrared Hyperspectral Image based on Deep Neural Network for Tumor Lesion Classification. European Journal of Applied Sciences, 9:273-281, 2021
10. Takamatsu T, Kitagawa Y, Akimoto K, Iwanami R, Endo Y, Takashima K, Okubo K, Umezawa M, Kuwata T, Sato D, Kadota T, Mitsui T, Ikematsu H, Yokota H, Soga K, Takemura H. Over 1000 nm Near-Infrared Multispectral Imaging System for Laparoscopic In Vivo Imaging. Sensors (Basel), 21:2021
11. Kadota T, Ikematsu H, Sasaki T, Saito Y, Ito M, Mizutani T, Ogawa G, Shitara K, Ito Y, Kushima R, Kanemitsu Y, Muto M. Protocol for a single-arm confirmatory trial of adjuvant chemoradiation for patients with high-risk rectal submucosal invasive cancer after local resection: Japan Clinical Oncology Group Study JCOG1612 (RESCUE study). BMJ Open, 10:e034947, 2020
12. Inaba A, Hori K, Yoda Y, Ikematsu H, Takano H, Matsuzaki H, Watanabe Y, Takeshita N, Tomioka T, Ishii G, Fujii S, Hayashi R, Yano T. Artificial intelligence system for detecting superficial laryngopharyngeal cancer with high efficiency of deep learning. Head Neck, 42:2581-2592, 2020
13. Sato D, Motegi A, Kadota T, Kojima T, Bando H, Shinmura K, Hori K, Yoda Y, Oono Y, Zenda S, Ikematsu H, Akimoto T, Yano T. Therapeutic results of proton beam therapy with concurrent chemotherapy for cT1 esophageal cancer and salvage endoscopic therapy for local recurrence. Esophagus, 17:305-311, 2020
14. Murano T, Ikematsu H, Shinmura K, Ito R, Minamide T, Sato D, Yamamoto Y, Takashima K, Kadota T, Yoda Y, Hori K, Oono Y, Yano T. Endoscopic prediction of advanced histology in colorectal lesions sized <10 mm using the Japan Narrow-band imaging Expert Team classification. Dig Endosc, 32:785-790, 2020
15. Kudo SE, Misawa M, Mori Y, Hotta K, Ohtsuka K, Ikematsu H, Saito Y, Takeda K, Nakamura H, Ichimasa K, Ishigaki T, Toyoshima N, Kudo T, Hayashi T, Wakamura K, Baba T, Ishida F, Inoue H, Itoh H, Oda M, Mori K. Artificial Intelligence-assisted System Improves Endoscopic Identification of Colorectal Neoplasms. Clin Gastroenterol Hepatol, 18:1874-1881.e2, 2020
16. Yoshida N, Hisabe T, Ikematsu H, Ishihara H, Terasawa M, Inaba A, Sato D, Cho H, Ego M, Tanaka Y, Yasuda R, Inoue K, Murakami T, Inada Y, Itoh Y, Saito Y. Comparison Between Linked Color Imaging and Blue Laser Imaging for Improving the Visibility of Flat Colorectal Polyps: A Multicenter Pilot Study. Dig Dis Sci, 65:2054-2062, 2020
17. Suyama M, Yoda Y, Yamamoto Y, Sunakawa H, Minamide T, Hori K, Ikematsu H, Yano T. Oxygen saturation imaging as a useful tool for visualizing the mode of action of photodynamic therapy for esophageal cancer. VideoGIE, 5:496-499, 2020
18. Itoh H, Nimura Y, Mori Y, Misawa M, Kudo SE, Hotta K, Ohtsuka K, Saito S, Saito Y, Ikematsu H, Hayashi Y, Oda M, Mori K. Robust endocytoscopic image classification based on higher-order symmetric tensor analysis and multi-scale topological statistics. Int J Comput Assist Radiol Surg, 15:2049-2059, 2020
19. Kadota T, Yoda Y, Hori K, Shinmura K, Oono Y, Ikematsu H, Yano T. Prophylactic steroid administration against strictures is not enough for mucosal defects involving the entire circumference of the esophageal lumen after esophageal endoscopic submucosal dissection (ESD). Esophagus, 17:440-447, 2020
20. Mori Y, Kudo SE, East JE, Rastogi A, Bretthauer M, Misawa M, Sekiguchi M, Matsuda T, Saito Y, Ikematsu H, Hotta K, Ohtsuka K, Kudo T, Mori K. Cost savings in colonoscopy with artificial intelligence-aided polyp diagnosis: an add-on analysis of a clinical trial (with video). Gastrointest Endosc, 92:905-911.e1, 2020
21. Sato D, Takamatsu T, Umezawa M, Kitagawa Y, Maeda K, Hosokawa N, Okubo K, Kamimura M, Kadota T, Akimoto T, Kinoshita T, Yano T, Kuwata T, Ikematsu H, Takemura H, Yokota H, Soga K. Distinction of surgically resected gastrointestinal stromal tumor by near-infrared hyperspectral imaging. Sci Rep, 10:21852, 2020
22. Matsuda T, Fujii T, Sano Y, Kudo SE, Oda Y, Hotta K, Shimoda T, Saito Y, Kobayashi N, Sekiguchi M, Konishi K, Ikematsu H, Iishi H, Takeuchi Y, Igarashi M, Kobayashi K, Sada M, Yamaguchi Y, Hasuda K, Shinohara T, Ishikawa H, Murakami Y, Taniguchi H, Fujimori T, Ajioka Y, Yoshida S. Randomised comparison of postpolypectomy surveillance intervals following a two-round baseline colonoscopy: the Japan Polyp Study Workgroup. Gut, 2020