Annual Report 2020
Division of Screening Technology
Takahisa Matsuda, Masau Sekiguchi, (Visiting Researcher) Kazuya Inoki, (Special research assistant) Tomi Abe, Noriko Abeshima, Orie Kitamura, Mio Shimamura, Mika Mori
Introduction
The Division of Screening Technology works as a part of the Screening Research Group in the Center for Public Health Sciences. The Screening Research Group is divided into two divisions: Division of Screening Assessment and Management/Division of Screening Technology. The Division of Screening Technology consists of 2 staff medical doctors, 5 special research assistants and 1 visiting researcher.
The Team and What We Do
The Division of Screening Technology aims to develop new diagnostic techniques that can be applied to cancer screening, as well as researching existing diagnostic methods that can be applied to medical examinations. We are also assessing a new close examination method in cancer screening. In addition, we also work on research aiming at risk stratification of people to be screened.
Research activities
We have been examining the cancer detection rate of each screening modality (e.g. chest CT, upper/lower GI endoscopy, MMG/tomosynthesis and breast ultrasonography, FDG-PETCT/MRI, CT-colonography), the characteristics of the detected cancer, and the false-positive rate for all individuals who underwent cancer screening from the establishment of our center in 2004. In addition, we aim to clarify the relationship between cancer screening and cancer death from long-term (prognosis survey) results. Moreover, the following researches are ongoing. 1) Field construction for verification of diagnostic tools for colorectal cancer and precancerous lesions using biomarkers (Oshima Study), 2) Japan Polyp Study: multicenter prospective cohort study to elucidate the preventive effect of colorectal cancer caused by polypectomy, 3) Development of an endoscope system for early detection of pancreatic cancer, 4) Study on the establishment and effectiveness assessment of screening model using colonoscopy (Aomori Project), 5) Cost-effectiveness analysis on GI screening and surveillance using endoscope, 6) Prospective study on colorectal cancer risk in first-degree relatives of colorectal cancer patients, 7) Prospective multicenter study to evaluate the relationship between the background of detection and clinicopathological feature of colorectal cancer, and 8)Study on the diagnostic performance of serum carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 19-9 levels for both gastrointestinal and multiple-organ cancer screening. Furthermore, the amino index (AICS) study has received plasma samples from 8,111 screening individuals, and comprehensive amino acid analysis has been completed. From now on, the analysis data will be collated with clinical data. Among them, the following six papers were published in this period.
Other research: We are collaborating with external researchers using 1,325 stool samples collected from the Oshima Study. (Research on colibactin-producing bacteria as fecal biomarkers, bacteria and bacterial flora as fecal biomarkers and their functions). In addition, 37 English articles were published, focusing on the diagnosis, treatment, and screening of colorectal and gastric cancers.
Future Prospects
We will promote screening development research to create evidence.
List of papers published in 2020
Journal
1. Nakajima T, Sakamoto T, Hori S, Yamada S, Ikematsu H, Harada K, Chiu HM, Kiriyama S, Michida T, Hotta K, Sakamoto N, Abe T, Chino A, Fukuzawa M, Kobayashi N, Fukase K, Matsuda T, Murakami Y, Ishikawa H, Saito Y. Optimal surveillance interval after piecemeal endoscopic mucosal resection for large colorectal neoplasia: a multicenter randomized controlled trial. Surg Endosc, 2021
2. Kudo SE, Ichimasa K, Villard B, Mori Y, Misawa M, Saito S, Hotta K, Saito Y, Matsuda T, Yamada K, Mitani T, Ohtsuka K, Chino A, Ide D, Imai K, Kishida Y, Nakamura K, Saiki Y, Tanaka M, Hoteya S, Yamashita S, Kinugasa Y, Fukuda M, Kudo T, Miyachi H, Ishida F, Itoh H, Oda M, Mori K. Artificial Intelligence System to Determine Risk of T1 Colorectal Cancer Metastasis to Lymph Node. Gastroenterology, 160:1075-1084.e2, 2021
3. Wong MCS, Rerknimitr R, Lee Goh K, Matsuda T, Kim HS, Wu DC, Wu KC, Yeoh KG, Chong VH, Ahmed F, Sollano JD, Menon J, Chiu HM, Li J, Ching JYL, Sung JJY. Development and Validation of the Asia-Pacific Proximal Colon Neoplasia Risk Score. Clin Gastroenterol Hepatol, 19:119-127.e1, 2021
4. Inoki K, Abe S, Tanaka Y, Yamamoto K, Hihara D, Ichijima R, Nakatani Y, Chen HY, Takamaru H, Sekiguchi M, Yamada M, Sakamoto T, Nonaka S, Suzuki H, Yoshinaga S, Oda I, Matsuda T, Saito Y. Reduced Intravenous Fluorescein Dose for Upper and Lower Gastrointestinal Tract Probe-Based Confocal Laser Endomicroscopy. Clin Endosc, 54:363-370, 2021
5. Misawa M, Kudo SE, Mori Y, Hotta K, Ohtsuka K, Matsuda T, Saito S, Kudo T, Baba T, Ishida F, Itoh H, Oda M, Mori K. Development of a computer-aided detection system for colonoscopy and a publicly accessible large colonoscopy video database (with video). Gastrointest Endosc, 93:960-967.e3, 2021
6. Okagawa Y, Abe S, Takamaru H, Sekiguchi M, Yamada M, Sakamoto T, Saito Y. A novel technique for adjusting traction direction during colorectal endoscopic submucosal dissection using S-O clip. Endoscopy, 53:E177-E178, 2021
7. Medina-Prado L, Hassan C, Dekker E, Bisschops R, Alfieri S, Bhandari P, Bourke MJ, Bravo R, Bustamante-Balen M, Dominitz J, Ferlitsch M, Fockens P, van Leerdam M, Lieberman D, Herráiz M, Kahi C, Kaminski M, Matsuda T, Moss A, Pellisé M, Pohl H, Rees C, Rex DK, Romero-Simó M, Rutter MD, Sharma P, Shaukat A, Thomas-Gibson S, Valori R, Jover R. When and How To Use Endoscopic Tattooing in the Colon: An International Delphi Agreement. Clin Gastroenterol Hepatol, 19:1038-1050, 2021
8. Sekiguchi M, Kakugawa Y, Takamaru H, Yamada M, Sakamoto T, Saito Y, Matsuda T. Risk of metachronous neoplastic lesions during post-polypectomy surveillance in individuals with advanced colorectal neoplasia at initial screening colonoscopy. J Gastroenterol Hepatol, 2021
9. Tanaka S, Saitoh Y, Matsuda T, Igarashi M, Matsumoto T, Iwao Y, Suzuki Y, Nozaki R, Sugai T, Oka S, Itabashi M, Sugihara KI, Tsuruta O, Hirata I, Nishida H, Miwa H, Enomoto N, Shimosegawa T, Koike K. Evidence-based clinical practice guidelines for management of colorectal polyps. J Gastroenterol, 56:323-335, 2021
10. Saito Y, Oka S, Kawamura T, Shimoda R, Sekiguchi M, Tamai N, Hotta K, Matsuda T, Misawa M, Tanaka S, Iriguchi Y, Nozaki R, Yamamoto H, Yoshida M, Fujimoto K, Inoue H. Colonoscopy screening and surveillance guidelines. Dig Endosc, 33:486-519, 2021
11. Mori Y, Kudo SE, East JE, Rastogi A, Bretthauer M, Misawa M, Sekiguchi M, Matsuda T, Saito Y, Ikematsu H, Hotta K, Ohtsuka K, Kudo T, Mori K. Cost savings in colonoscopy with artificial intelligence-aided polyp diagnosis: an add-on analysis of a clinical trial (with video). Gastrointest Endosc, 92:905-911.e1, 2020
12. Matsuda T, Fujii T, Sano Y, Kudo SE, Oda Y, Hotta K, Shimoda T, Saito Y, Kobayashi N, Sekiguchi M, Konishi K, Ikematsu H, Iishi H, Takeuchi Y, Igarashi M, Kobayashi K, Sada M, Yamaguchi Y, Hasuda K, Shinohara T, Ishikawa H, Murakami Y, Taniguchi H, Fujimori T, Ajioka Y, Yoshida S. Randomised comparison of postpolypectomy surveillance intervals following a two-round baseline colonoscopy: the Japan Polyp Study Workgroup. Gut, 2020
13. Kato M, Tanaka K, Kida M, Ryozawa S, Matsuda K, Fujishiro M, Saito Y, Ohtsuka K, Oda I, Katada C, Kobayashi K, Hoteya S, Horimatsu T, Kodashima S, Matsuda T, Muto M, Yamamoto H, Iwakiri R, Kutsumi H, Miyata H, Kato M, Haruma K, Fujimoto K, Uemura N, Kaminishi M, Tajiri H. Multicenter database registry for endoscopic retrograde cholangiopancreatography: Japan Endoscopic Database Project. Dig Endosc, 32:494-502, 2020
14. Abe S, Saito Y, Tanaka Y, Ego M, Yanagisawa F, Kawashima K, Takamaru H, Sekiguchi M, Yamada M, Sakamoto T, Matsuda T, Goto O, Yahagi N. A novel endoscopic hand-suturing technique for defect closure after colorectal endoscopic submucosal dissection: a pilot study. Endoscopy, 52:780-785, 2020
15. Abe S, Wu SYS, Ego M, Takamaru H, Sekiguchi M, Yamada M, Nonaka S, Sakamoto T, Suzuki H, Yoshinaga S, Matsuda T, Oda I, Saito Y. Efficacy of Current Traction Techniques for Endoscopic Submucosal Dissection. Gut Liver, 14:673-684, 2020
16. Sakamoto T, Takamaru H, Sekiguchi M, Yamada M, Matsuda T, Saito Y. Reliability of Japan Narrow-Band Imaging Expert Team Classification for the Diagnosis of Colorectal Neoplasms: A Pilot Study. Digestion, 101:638-643, 2020
17. Kasuga K, Sakamoto T, Takamaru H, Sekiguchi M, Yamada M, Yamazaki N, Hashimoto T, Uraoka T, Saito Y. Endoscopic reduction of colocolonic intussusception due to metastatic malignant melanoma: A case report. World J Clin Cases, 8:5816-5820, 2020
18. Cho H, Budhathoki S, Kanehara R, Goto A, Yamaji T, Kakugawa Y, Saito Y, Matsuda T, Iwasaki M, Tsugane S. Association between dietary sugar intake and colorectal adenoma among cancer screening examinees in Japan. Cancer Sci, 111:3862-3872, 2020
19. Takamaru H, Goto R, Yamada M, Sakamoto T, Matsuda T, Saito Y. Predicting and managing complications following colonoscopy: risk factors and management of advanced interventional endoscopy with a focus on colorectal ESD. Expert Rev Med Devices, 17:929-936, 2020
20. Sekiguchi M, Kakugawa Y, Nakamura K, Matsumoto M, Tomizawa Y, Murakami Y, Saito Y, Matsuda T. Family history of colorectal cancer and prevalence of advanced colorectal neoplasia in asymptomatic screened populations in different age groups. Gastrointest Endosc, 91:1361-1370, 2020
21. Sekiguchi M, Kakugawa Y, Matsumoto M, Nakamura K, Mizuguchi Y, Takamaru H, Yamada M, Sakamoto T, Saito Y, Matsuda T. Prevalence of serrated lesions, risk factors, and their association with synchronous advanced colorectal neoplasia in asymptomatic screened individuals. J Gastroenterol Hepatol, 35:1938-1944, 2020
22. Sekiguchi M, Igarashi A, Sakamoto T, Saito Y, Esaki M, Matsuda T. Cost-effectiveness analysis of colorectal cancer screening using colonoscopy, fecal immunochemical test, and risk score. J Gastroenterol Hepatol, 35:1555-1561, 2020
23. Ichijima R, Abe S, Kobayashi S, Minagawa T, Tagawa T, Nakajima T, Yamada M, Takamaru H, Sekiguchi M, Sakamoto T, Oda I, Matsuda T, Saito Y, Gotoda T. Efficacy of Full-Spectrum Endoscopy to Visualize the Major Duodenal Papilla in Patients with Familial Adenomatous Polyposis. Digestion, 101:563-570, 2020
24. Inoki K, Sakamoto T, Takamaru H, Sekiguchi M, Yamada M, Matsuda T, Saito Y. The Diagnostic Performance for Colorectal Neoplasms Using Magnified Endoscopy Differs between Experts and Novice Endoscopists: A Post Hoc Analysis. Digestion, 101:590-597, 2020
25. Inoki K, Kakugawa Y, Takamaru H, Sekiguchi M, Matsumoto M, Matsuda T, Ito A, Tanaka T, Inamoto Y, Fuji S, Kurosawa S, Kim SW, Fukuda T, Ohe Y, Saito Y. Capsule Endoscopy after Hematopoietic Stem Cell Transplantation Can Predict Transplant-Related Mortality. Digestion, 101:198-207, 2020
26. Sekiguchi M, Kakugawa Y, Nakamura K, Matsumoto M, Takamaru H, Yamada M, Sakamoto T, Saito Y, Matsuda T. Feasibility of observational screening colonoscopy followed by deferred polypectomy. J Gastroenterol Hepatol, 35:263-270, 2020
27. Shimizu Y, Mizuno S, Fujinami N, Suzuki T, Saito K, Konishi M, Takahashi S, Gotohda N, Tada T, Toyoda H, Kumada T, Miura M, Suto K, Yamaji T, Matsuda T, Endo I, Nakatsura T. Plasma and tumoral glypican-3 levels are correlated in patients with hepatitis C virus-related hepatocellular carcinoma. Cancer Sci, 111:334-342, 2020
28. Hotta K, Matsuda T, Tanaka K. Post-polypectomy colonoscopy surveillance in the real clinical practice: Nationwide survey of 792 board certified institutions of the Japan Gastroenterological Endoscopy Society. Dig Endosc, 32:824, 2020
29. Kakinuma R, Muramatsu Y, Asamura H, Watanabe SI, Kusumoto M, Tsuchida T, Kaneko M, Tsuta K, Maeshima AM, Ishii G, Nagai K, Yamaji T, Matsuda T, Moriyama N. Low-dose CT lung cancer screening in never-smokers and smokers: results of an eight-year observational study. Transl Lung Cancer Res, 9:10-22, 2020
30. Yokota T, Saito Y, Takamaru H, Sekine S, Nakajima T, Yamada M, Sakamoto T, Taniguchi H, Kushima R, Tsukamoto S, Shida D, Kanemitsu Y, Matsuda T. Spontaneous Regression of Mismatch Repair-Deficient Colon Cancer: A Case Series. Clin Gastroenterol Hepatol, 2020
31. Hotta K, Matsuda T, Tanaka K. Large-scale questionnaire on the usage of cold snare polypectomy for colorectal polyps in Japanese clinical practice. Dig Endosc, 32:993, 2020
32. Dekker E, Chiu HM, Lansdorp-Vogelaar I. Colorectal Cancer Screening in the Novel Coronavirus Disease-2019 Era. Gastroenterology, 159:1998-2003, 2020
33. Tang RSY, Lee JWJ, Chang LC, Ong DEH, Chiu HM, Matsuda T, Kim HS, Sekiguchi M, Leong RW, Ho AMY, Lam TYT, Tse YK, Lin L, Yeoh KG, Lau JYW, Sung JJY. Two vs One Forward View Examination of Right Colon on Adenoma Detection: An International Multicenter Randomized Trial. Clin Gastroenterol Hepatol, 2020
34. Takamaru H, Kawaguchi Y, Oda I, Sekiguchi M, Yamada M, Abe S, Nonaka S, Suzuki H, Yoshinaga S, Saito Y. A new reliable acoustic respiratory monitoring technology during upper gastrointestinal tract therapeutic endoscopy with CO(2) insufflation. J Clin Monit Comput, 2020
35. Sekiguchi M, Matsuda T. Limited usefulness of serum carcinoembryonic antigen and carbohydrate antigen 19-9 levels for gastrointestinal and whole-body cancer screening. Sci Rep, 10:18202, 2020
36. Kato T, Nagata K, Yamamichi J, Tanaka S, Honda T, Shimizu N, Utano K, Hirayama M, Matsumoto H, Horita S. Preference and Experience of Colonic Examination for Participants Presenting to Hospitals with a Positive Fecal Immunochemical Test Result. Patient Prefer Adherence, 14:2017-2025, 2020
Book
1. Sekiguchi M, Matsuda T. Chapter 4: Endoscopy-Based Colorectal Cancer Screening. In: Chiu HM, Chen HH (ed), Colorectal Cancer Screening: Theory and Practical Application, Switzerland, Springer, pp 41-54, 2021