Jump to Main Contents
研究所ロゴ

Home > Organization > Divisions and Independent Research Units > Group for Cancer Development and Progression > Division of Cancer RNA Research

Division of Cancer RNA Research

Our News

Dec 1, 2022

Natsuko Shinohara joined us as a technician!

Nov 30, 2022

Akihide Yoshimi chaired "Ryugaku no susume" at the Molecular Biology Society of Japan 2022.

Nov 24, 2022

 Akihide Yoshimi and Kazuki Nishimura gave invited talks at MSD Urology Seminar.

Nov 19, 2022

 Akihide Yoshimi gave an invited talk at Cancer Stem Cell Symposium.

Nov 15, 2022

Akihide Yoshimi gave an invited talk at The Japanese Environmental Mutagen and Genome Society (JEMS).

Nov 1, 2022

Akihide Yoshimi gave an invited talk at Kitasato University School of Science.

Oct 31, 2022

Akihide Yoshimi had an invited talk at Aichi Cancer Center.

Oct 20, 2022

Kazuki Nishimura was awarded the Young Oncologist Award from Japan Society of Clonical Oncology (JSCO)!

Oct 14, 2022

Akihide Yoshimi gave an invited talk at the 84th Annual Meeting of JSH (the Japanese Society of Hematology).

Oct 12, 2022

Akihide Yoshimi participated in the award ceremony of BioJapan 2022.

Oct 7, 2022

Akihide Yoshimi gave an invited talk at The 8th Canadian Conference on Epigenetics.

Oct 7, 2022

Akihide Yoshimi gave an invited talk at The 159th Pediatric/Hematology/Oncology/Immunology Seminar.

Oct 3, 2022   

Collaborative work with Div. Genome Analysis Platform Development was published in Nature Communications!

Contributors: Asuka Kawachi, Ikuko Omori, Hirofumi Yamauchi, Akihide Yoshimi

Oct 1, 2022

Akihide Yoshimi was awarded the JCA-Mauvernay Award Session from Japanese Cancer Association (JCA).

Oct 1, 2022

Akihide Yoshimi had following three invited talks at the 81th annual meeting of Japanese Cancer Association:

  • The JCA-Mauvernay Award Session
  • International Session 11
  • Morning Lecture 13
Sep 16, 2022

Our research proposal was accepted by AMED (P-PROMOTE; PI: Akihide Yoshimi).

Sep 16, 2022

Mayumi Hanzawa joined us as a technician!

Sep 1, 2022

Our lab was promoted to "Division of Cancer RNA Research"!!
Akihide Yoshimi was promoted to Chief of the division.

Aug 31, 2022

Our research proposal was accepted by JSPS (Grant-in-Aid for Research Activity Start-up ; PI: Asuka Kawachi)

Aug 5, 2022

Our review paper was published in Cancers!

Contributors: Yu Hai, Asuka Kawachi, Akihide Yoshimi

Aug 1, 2022

Kyoko Yamamoto joined us as a postdoc!

Jul 15, 2022

Akihide Yoshimi was awarded the Bioindustry Research Award 2022 from JBA.

Jun 16, 2022

Asuka Kawachi was selected for the 8th Mansfield-PhRMA Scholar!

May 1, 2022

Ayano Go joined us as a technician!

Apr 1, 2022

Akihide Yoshimi became a visiting professor of Kitasato University School of Science.

Apr 1, 2022

Yuri Yamasu joined us as a PhD student!

Mar 26, 2022

Akihide Yoshimi had an invited talk at the 2022 International Cancer Symposium.

Mar 1, 2022

Asuka Kawachi joined us as a Researcher!

Dec 17, 2021

Guzhanuer Ailiken was selected for the JSPS Postdoctoral Fellowships for Research in Japan!

Dec 2, 2021

Akihide Yoshimi had an invited talk at the 44st Annual Meeting of the Molecular Biology Society of Japan.

Dec 1, 2021

Our review paper is out in Cancer Science.

Yamauchi H, Nishimura K, Yoshimi A. Aberrant RNA splicing and therapeutic opportunities in cancers. Cancer Science, in press. doi.org/10.1111/cas.15213

Nov 26, 2021 Our research proposal was accepted by JST (Fusion Oriented Research for Disruptive Science and Technology ; PI: Akihide Yoshimi)
Nov 26, 2021 Our research proposal was accepted by JST (Fusion Oriented Research for Disruptive Science and Technology ; PI: Atsushi Oishi: External Research Staff)
Nov 1, 2021 Marimu Sakumoto joined us as an office administrator!
Oct 13, 2021 Our first paper is out in Nature!

Collaboration with Dr. Savvas Savvides Group at Ghent university/VIB-UGent Center for Inflammation Research

De Munck S, Provost M, Kurikawa M, Omori I, Mukohyama J, Felix J, Bloch Y, Abdel-Wahab O, Bazen F, Yoshimi A, Savvides SN. Structural basis of cytokine-mediated activation of ALK family receptors. Nature. 2021 Dec;600(7887):143-147. doi.org/10.1038/s41586-021-03959-5.

Press Release
Oct 5, 2021 Our research proposal was accepted by AMED (Science and Technology Platform Program for Advanced Biological Medicine; co-PI: Akihide Yoshimi)
Oct 1,2021 Kazuki Nishimura joined us as an External Research Staff!
Sep 27, 2021 Michiko Kurikawa was selected for the JSPS Research Fellowships for Young Scientists (DC1)!
Sep 17, 2021 Kota Otsuki joined us as a trainee!
Sep 12, 2021 Akihide Yoshimi had an invited talk at the 1st JCA-AACR Precision Cancer Medicine International Conference
 Sep 1, 2021 Guzhanuer Ailiken joined us as a postdoc!
Aug 16, 2021 Atsuhito Nakayama joined us as a PhD student!
Jul 30, 2021 Our research proposal was accepted by Takeda Science Foundation (Takeda hosho Medical Research grant; PI: Akihide Yoshimi)
Jul 6, 2021 Akihide Yoshimi had an invited talk at the 39th Sapporo International Cancer Symposium
Jul 6, 2021 Michiko Kurikawa and Hirofumi Yamauchi gave poster presentations at the 39th Sapporo International Cancer Symposium
Apr 5, 2021 Our research proposal was accepted by JSPS (Grant-in-Aid for Scientific Research (A); PI: Akihide Yoshimi)
Apr 1, 2021 Hirofumi Yamauchi and Michiko Kurikawa started his/her PhD courses!
Apr 1, 2021 Ikuko Omori joined us as a postdoc!
Jan 15, 2021 Our research proposal was accepted by AMED (Japan-Canada Joint Grant: SICORP ; PI: Akihide Yoshimi)
Jan 1, 2021 Takahiro Nishino joined us as a trainee!
Dec 1, 2020 Hanako Nakamura joined us as a technician!
Nov 13, 2020 Akihide Yoshimi had an invited talk at the 7th Cancer Epigenomics Symposium
Nov 12, 2020 Akihide Yoshimi was selected for the Leukemia & Lymphoma Society’s CDP (Special Fellow) Achievement Award!
Nov 1, 2021 Atsuro Oishi joined us as an External Research Staff!
Oct 16, 2020 Xiaohui Song joined us as a technician!
Oct 1, 2020 Akihide Yoshimi presented our recent work at the 79th Japanese Cancer Association Annual Meeting
Oct 1, 2020 Hirofumi Yamauchi joined us as an External Resarch Staff!
Aug 18, 2020 Our research proposal was accepted by JSPS (Home-Returning Researcher Development Research; PI: Akihide Yoshimi)
Aug 1, 2020 Michiko Kurikawa joined us as an External Resarch Staff!
Aug 18, 2020 Our research proposal was accepted by JSPS (Home-Returning Researcher Development Research; PI: Akihide Yoshimi)
Jul 1, 2020 Birthday of Cancer RNA Research Unit!! Akihide Yoshimi joined as a Section Head!



Our Research Interest


Our studies have been focused on how RNA processing including RNA splicing is altered in cancer and functionally drives cancer initiation and maintenance. The advent of high-throughput transcriptome sequencing has provided a wealth of information on RNA splicing on a genome-wide scale. It is now understood that > 95% of human genes are subject to alternative splicing. RNA splicing is considered to be a major mediator of proteome diversity through its ability to generate multiple transcripts with differing amino acid sequences from a single gene. The discovery of recurrent mutations in components of the RNA-splicing machinery in 2011 further highlighted the importance of aberrant splicing in cancer as well as a potential therapeutic vulnerability for cells bearing these mutations. Despite the major advances in our understanding of the genomics, molecular biology and therapeutic implications of altered RNA processing in cancer, the full contribution of aberrant RNA splicing to cancer pathogenesis has not been fully elucidated. Our aim is to contribute to the full understanding of the pathogenic roles of altered RNA processing in a variety of cancers and to the development of therapeutically efficacious and safe strategies to improve the outcome of cancer patients.