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Treatment of neuroblastoma with a demethylating agent
The CIMP could cause poor prognosis in neuroblastomas by inducing methylation of multiple genes with various incidences. Simultaneous reversal of methylation of multiple genes by a demethylating agent could be an effective treatment for CIMP-positive neuroblastomas (Fig. ). We showed that treatment of a neuroblastoma cell line with a demethylating agent, 5-aza-dC, caused demethylation of multiple genes, and enhanced 13-cis-retinoic acid-induced neuronal differentiation (Abe et al., 2008 ). Using a neuroblastoma xenograft model, demethylation of multiple genes is being analyzed in vivo.
Fig. Strategy of simultaneous reversal of multiple genes in neuroblastoma by a demethylating agent
Simultaneous reversal of methylation of multiple genes by a demethylating agent could be an effective treatment for CIMP (+) neuroblastomas.