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Home > Organization > Divisions and Independent Research Units > Group for Development of Molecular diagnostics and Individualized Therapy > Division of Epigenomics > Research Projects > Prediction of presence of lymph node metastasis of esophageal cancer by DNA methylation analysis

Prediction of presence of lymph node metastasis of esophageal cancer by DNA methylation analysis

The presence of lymph node metastasis is an important factor in deciding treatment strategy and prognosis. However, there has been no reliable molecular marker to detect the presence of lymph node metastasis. We are isolating CpG islands whose methylation is associated with the presence of lymph node metastasis. For this end, 1) a pool of esophageal cancers without metastasis and a pool of cancers with metastasis, and 2) a pool of esophageal cancers without metastasis and a pool of metastasis foci in lymph nodes were compared using comprehensive microarray analysis of DNA methylation. Not only in the screening sample set, but also in an independent sample set for validation, the methylation level of a marker gene was associated with the presence of lymph node metastasis (Takahashi et al., 2015).

metastasis of esophageal cancer

Fig. Marker genes whose DNA methylation was associated with the presence of lymph node metastasis
Gene A is a marker gene whose DNA methylation was associated with the presence of lymph node metastasis, not only in the screening sample set, but also in the independent sample set for validation.