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Research Papers

  1. Arakawa A, Ichikawa H, Kubo T, Motoi N, Kumamoto T, Nakajima M, Yonemori K, Noguchi E, Sunami K, Shiraishi K, Kakishima H, Yoshida H, Hishiki T, Kawakubo N, Kuroda T, Kiyokawa T, Yamada K, Yanaihara N, Takahashi K, Okamoto A, Hirabayashi S, Hasegawa D, Manabe A, Ono K, Matsuoka M, Arai Y, Togashi Y, Shibata T, Nishikawa H, Aoki K, Yamamoto N, Kohno T*, Ogawa C*. Vaginal Transmission of Cancer from Mothers with Cervical Cancer to Infants. N Engl J Med. 384(1):42-50, 2021. doi: 10.1056/NEJMoa2030391.

  2. Ogiwara H*, Takahashi K, Sasaki M, Kuroda T, Yoshida H, Watanabe R, Maruyama A, Makinoshima H, Chiwaki F, Sasaki H, Kato T,Okamoto A, Kohno T*. Targeting the vulnerability of glutathione metabolism in ARID1A-deficient cancers. Cancer Cell, 35(2):177-190.e8, 2019.

  3. Nakaoku T, Kohno T*, Araki M, Niho S, Chauhan R, Knowles PP, Tsuchihara K, Matsumoto S, Shimada Y, Mimaki S, Ishii G, Ichikawa H, Nagatoishi S, Tsumoto K, Okuno Y, Yoh K,McDonald NQ, Goto K. A secondary RET mutation in the activation loop conferring resistance to vandetanib. Nature Communications, 9(1):625, 2018.
  4. Kohno T*. Implementation of  “Clinical Sequencing” in Cancer Genome Medicine in Japan. Cancer Sci, 109(3):507-512, 2018.
  5. Honda T, Sakashita H, Masai K, Totsuka H, Motoi N, Kobayashi M, Akashi T, Mimaki S, Tsuchihara K, Chiku S, Shiraishi K, Shimada Y, Otsuka A, Kanai Y, Okubo K, Watanabe S, Tsuta K, Inase N, Kohno T*Deleterious pulmonary surfactant system gene mutations in lung adenocarcinomas associated with usual interstitial pneumonia. JCO Prec Oncol, 2018. https://doi.org/10.1200/PO.17.00301.

  6. Yoh K, Seto T, Satouchi M, Nishio M, Yamamoto N, Murakami H, Nogami N, Matsumoto S, Kohno T, Tsuta K, Tsuchihara K, Ishii G, Nomura S, Sato A, Ohtsu A, Ohe Y, Goto K*. Vandetanib in patients with previously treated RET-rearranged advanced non-small-cell lung cancer (LURET): an open-label, multicentre phase 2 trial. Lancet Respir Med. 5:42-50, 2017.
  7. Seow WJ, Matsuo K, Hsiung CA, Shiraishi K (co-first author), … , Rothman N, Kohno T, Chanock SJ, Lan Q*. Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations. Hum Mol Genet. 26:454-465, 2017.
  8. George J, Saito M (co-first author), Tsuta K, Iwakawa R, Shiraishi K, Scheel AH, Uchida S, Watanabe SI, Nishikawa R, Noguchi M, Peifer M, Jang SJ, Petersen I, Büttner R, Harris CC, Yokota J, Thomas RK*, Kohno T*. Genomic amplification of CD274 (PD-L1) in small-cell lung cancer. Clin Cancer Res. 23:1220-1226, 2017.
  9. Yamamoto Y, Gotoh S, Korogi Y, Seki M, Konishi S, Ikeo S, Sone N, Nagasaki T, Matsumoto H, Muro S, Ito I, Hirai T, Kohno T, Suzuki Y, Mishima M. Long-term expansion of alveolar stem cells derived from human iPS cells in organoids. Nat Methods. 14:1097-1106, 2017.

  10. Shiraishi K, … , Kohno T*. Association of variations in HLA-class II and other loci with susceptibility to EGFR- mutated lung adenocarcinoma. Nat Commun. 7:12451, 2016.
  11. Ogiwara H, Sasaki M, … , Kohno T*. Targeting p300 addiction in CBP-deficient cancers causes synthetic lethality via apoptotic cell death due to abrogation of MYC expression. Cancer Discovery. 6(4):430-445, 2016.
  12. Saito M, Shiraishi K, Kunitoh H, Takenoshita S, Yokota J, Kohno T*. Gene aberrations for precision medicine against lung adenocarcinoma. Cancer Sci. 107:713-20, 2016
  13. Wang Z, Seow WJ, Shiraishi K (co-first author), Hsiung CA, Matsuo K, … , Kohno T, Yokota J, Kunitoh H, … , Kubo M, Chanock SJ, Rothman N, Lan Q*. Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women. Hum Mol Genet. 25:620-9, 2016
  14. Tanabe Y, Ichikawa H, Kohno T, Yoshida H, Kubo T, Kato M, Iwasa S, Ochiai A, Yamamoto N, Fujiwara Y, Tamura K*. Comprehensive screening of target molecules by next-generation sequencing in patients with malignant solid tumors: guiding entry into phase I clinical trials. Mol Cancer. 15:73, 2016.
  15. Murayama T, Nakaoku T (co-first author), Enari M, Nishimura T, Tominaga K, Nakata A, Tojo A, Sugano S, Kohno T*, Gotoh N*. Oncogenic Fusion Gene CD74-NRG1 Confers Cancer Stem Cell-like Properties in Lung Cancer through a IGF2 Autocrine/Paracrine Circuit. Cancer Res. 76(4):974-83, 2016.
  16. Saito M, Shimada Y, Shiraishi K,… , Kohno T*. Development of lung adenocarcinomas with exclusive dependence on oncogene fusions. Cancer Res. 75(11):2264-71, 2015.
  17. George J, Lim JS, … , Kohno T, … , Peifer M, Sage J, Thomas RK*. Comprehensive genomic profiles of small cell lung cancer. Nature, 524(7563):47-53, 2015.
  18. Seki Y, Mizukami T, Kohno T. Molecular process producing oncogene fusion in lung cancer cells by illegitimate repair of DNA double-strand breaks. Biomolecules 5(4):2464-76, 2015.
  19. Oike T, Ogiwara H, Nakano T, Kohno T*. Proposal for a synthetic lethality therapy using the paralog dependence of cancer cells-response. Cancer Res. 74(17):4948-9, 2014.
  20. Nakaoku T, Tsuta K, Ichikawa H, Shiraishi K, Sakamoto H, Enari M, Furuta K, Shimada Y, Ogiwara H, Watanabe SI, Nokihara H, Yasuda K, Hiramoto M, Nammo T, Ishigame T, Schetter AJ, Okayama H, Harris CC, Kim YH, Mishima M, Yokota J, Yoshida T, Kohno T*. Druggable oncogene fusions in invasive mucinous lung adenocarcinoma. Clin Cancer Res. 20(12):3087-3093, 2014.
  21. Mizukami T, Shiraishi K, Shimada Y, Ogiwara H, Tsuta K, Ichikawa H, Sakamoto H, Kato M, Shibata T, Nakano T, Kohno T*. Molecular mechanisms underlying oncogenic RET fusion in lung adenocarcinoma. J Thoracic Oncol. 9(5):622-630, 2014.
  22. Oike T, Ogiwara H, … , Kohno T*. A synthetic lethality-based strategy to treat cancers harboring a genetic deficiency in the chromatin remodeling factor BRG1. Cancer Res. 73(17):5508-5518, 2013.
  23. Shiraishi K, Kunitoh H, Daigo Y, … , Kohno T*. A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population. Nature Genetics, 44(8):900-903, 2012.
  24. Kohno T*, Ichikawa H (co-first author), … , Shibata T. KIF5B-RET fusions in lung adenocarcinoma. Nature Medicine, 18(3):375-377, 2012.
  25. Lan Q, Hsiung CA, Matsuo K, … , Kohno T, … , Shiraishi K, … , Chanock SJ, Rothman N*. Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. Nature Genetics, 44(12):1330-5, 2012.
  26. Ogiwara H, Ui A, Otsuka A, Satoh H, Yokomi I, Nakajima S, Yasui A, Yokota J, Kohno T*. Histone acetylation by CBP and p300 at double strand break sites facilitates SWI/SNF chromatin remodeling and the recruitment of non-homologous end joining factors. Oncogene, 30(18):2135-2146, 2011.