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Home > Organization > Divisions and Independent Research Units > Group for Development of Molecular diagnostics and Individualized Therapy > Division of Epigenomics

Division of Epigenomics

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This Division focuses on carcinogenic mechanisms, and it is especially known for its research in epigenetic mechanisms of carcinogenesis. The Division developed one of the earliest methods for genome-wide screening method for differences in DNA methylation, designated as MS-RDA (Ushijima et al., 1997 , Ushijima, 2005 ). The method was successfully used not only to identify tumor-suppressor genes (Kaneda et al., 2004 ), but also to isolate a prognostic marker that is superior to clinically used ones (Abe et al., 2005 ) and to establish a novel concept of "epigenetic field for cancerization" that can be utilized as a cancer risk marker (Maekita et al., 2006 , Nakajima et al., 2006 , Ushijima, 2007 ).